4CFVB

Structure-based design of c8-substituted o6-cyclohexylmethoxyguanine cdk1 and 2 inhibitors.
Total Genus 97

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
97
sequence length
262
structure length
262
Chain Sequence
GVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTINQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
3H1 (172-174)EMPTYTI1 (175-178)AH3 (229-244)AH1 (178-193)3H2 (199-202)TI2 (196-199)AH2 (208-225)TI3 (203-206)3H3 (250-252)AH4 (253-268)Updating...
connected with : NaN
molecule tags Transferase
source organism Homo sapiens
publication title 8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode.
pubmed doi rcsb
molecule keywords CYCLIN-DEPENDENT KINASE 2
total genus 97
structure length 262
sequence length 262
chains with identical sequence D
ec nomenclature
pdb deposition date 2013-11-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00134 Cyclin_N Cyclin, N-terminal domain
B PF02984 Cyclin_C Cyclin, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin-like 4cfvB01
1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin-like 4cfvB02
2PK2A 3BLQB 4EOJB 3LQ5B 3BHTB 1GH6B 1AISB 1O9KB 2C5NB 5LQFB 4EONB 3MY5B 3O0GD 2UZBB 1QMZB 4F7LB 1N4MA 4RODA 2W2HA 3MI9B 5HQ0B 1D3UB 3TNIB 3H4CA 4BCGB 4BCMB 4CFNB 5L2WB 4BCQD 4YC3B 1VYWB 1FVVB 4CFUD 5HBJB 5FGKB 3TN8B 3EOCB 1OKWB 2QDJA 4BCQB 4EOIB 4CFUB 1JOWA 3TNWB 2WFYB 4YOZA 3DDQB 2IW8B 1H4LD 1VINA 2IW6B 1ZP2A 1OIUB 2C4GB 1H1RB 1GUXB 3EJ1B 1OL2B 4OR5B 4EOLB 4F70B 1JSUB 1AD6A 5LMKB 1XO2A 1JKWA 3POMA 4II5B 4KRDB 2F2CA 4BCMD 1H24B 5CYIB 2BKZB 5CEIB 4F6UB 2PK9B 3TNHB 4KRCB 2I40B 1H1PB 4F7NB 5EFQB 4CXAB 4F7SB 4NSTB 1H26B 3BLRB 4EORB 4ELJA 3K7AM 2UZEB 4BCND 2W96A 2WMBB 1UNLD 4EOMB 1UNGD 3MIAB 3MY1B 2I53A 3BHVB 4BCIB 4ELLA 2WMAB 4CFWB 4BCNB 4EOPB 1TFBA 4CFMB 1KXUA 2UZDB 2B9RA 4YOSA 1JSTB 3G33B 2C5OB 1H1SB 2WXVB 1OIYB 4OGRB 1OI9B 1OL1B 1OKVB 2CJMB 4ROEA 4YOOA 2WIPB 1PKDB 1H25B 3BHUB 4BCHB 4EOOB 2JGZB 4EOQB 2X1NB 2C6TB 4EOKB 5HVYB 3EIDB 4F6WB 2WEVB 5ACBA 1URCB 5IDPB 1FINB 2BPMB 1P5EB 3RGFB 4BCFB 2V22B 1E9HB 5HBEB 1C9BA 1O9KA 2WIHB 1GY3B 3F5XB 2R7GA 4CRLB 4EC9B 4F7JB 2CCIB 4BCOB 2CCHB 2C5XB 4Y72B 4UN0A 4EOSB 2WHBB 3QHWB 4G6LB 4BCPB 4I3ZB 1H27B 4CFXB 4ROCA 1H1QB 2UZLB 4TTHA 1F5QB 2IW9B 2WPAB 2W9FA 5IF1B 2W9ZA 5HNBB 1G3NC 4CFVB 4BCKB 2G9XB 2C5VB 2IVXA 1VOLA 1OGUB 1GUXA 1BU2A 3DDPB 4FX3B 5I5ZB 3BLHB 4EC8B 2UUEB 3DOGB 2PMIB 4IMYB 4F6SB 3QHRB 5BNJB 4BCJB 2W99A 5HBHB 3M03A 5ICPB 2EUFA 5IDNB 1UNHD 2PHGA 1H28B 1W98B
chains in the Genus database with same CATH superfamily
3LQ5B 1IREB 5LQFB 2D0QB 1QMZB 2DXCB 2W2HA 4NC6A 2ZPGB 2BS2A 2ZPBB 4BCQD 1OKWB 4BCQB 4HNUA 3TNWB 2ZPFB 4OB3B 4JX6A 4OR5B 1H1RB 1GUXB 3QYEA 4F70B 4AI6A 5LMKB 3POMA 2F2CA 4AKIA 3A8MB 3BLRB 3K7AM 4BCND 1UNLD 4EOMB 1UNGD 3KHIA 3MIAB 4BCIB 3WVEB 4CFWB 4BCNB 2QFZA 2QQ8A 2B9RA 3BG3A 1JSTB 3X25B 1OI9B 2WIPB 2ZZDB 3X26B 4BCHB 3QYBA 4EOKB 4F6WB 1TD6A 3QZ5B 4BCFB 1V29B 4CRLB 4F7JB 1UGQB 4BCOB 2C5XB 4I3ZB 3DTOA 3HHTB 1UGRB 4TTHA 5DQWA 4BXXX 2W9ZA 5HNBB 2C5VB 4EC8B 4AKGA 2UUEB 3DOGB 3QYHB 3M03A 1UNHD 2ZPIB 2PK2A 4EOJB 4JX4A 4M6VA 3QZ9B 1AISB 2C5NB 3A8LB 3MY5B 3VYGB 3QWLA 1D3UB 4BCMB 2BS3A 4CFNB 4CFUD 5FGKB 3TN8B 2QDJA 4CFUB 3A8GB 4YOZA 2IW8B 4EOLB 1OIUB 3VKGA 1OL2B 1JSUB 1JKWA 5CEIB 2PK9B 3TNHB 4KRCB 4F7SB 4EORB 4HLQA 2WMBB 3A8HB 4JX5A 1FKMA 2BS4A 2I53A 3BHVB 3TW7A 4ZGJB 3GTMS 3G33B 4FM4B 4OGRB 2CJMB 2DD5B 4YOOA 1H25B 4EOOB 2PJQA 3X24B 2WEVB 5ACBA 5IDPB 1FINB 1E7PA 1C9BA 4HNVA 3HZJA 4Y72B 2DPPB 2WHBB 1H27B 3HBLA 1H1QB 3BG5A 2ZCFB 2ZPEB 5IF1B 4ZGDB 1VOLA 1OGUB 1GUXA 3DDPB 1UGPB 4FX3B 4BY7X 2PMIB 4F6SB 3QHRB 4BCJB 2W99A 2ZPHB 1W98B 1O9KB 3O0GD 2UZBB 4F7LB 1N4MA 3X20B 4RODA 5HQ0B 5L2WB 4YC3B 1VYWB 1FVVB 3QXEB 2WJ9A 4EOIB 1JOWA 4LOCA 2WFYB 2CZ7B 3DDQB 1ZP2A 2G77A 2IW6B 4BBRM 1UGSB 1AHJB 1XO2A 4BCMD 1H24B 2BKZB 4MFDA 2I40B 4MIMA 4NSTB 2UZEB 4HNTA 3DL1A 3MY1B 4ELLA 2WMAB 2QF7A 3VYHB 1KXUA 2UZDB 4YOSA 4AKHA 1H1SB 2CZ1B 2WXVB 1OIYB 1OKVB 2QDYB 1PKDB 4ZGEB 2DXBB 4EOQB 2X1NB 2C6TB 3EIDB 1URCB 2BPMB 1ENWA 3RGFB 2V22B 3HO8A 3QYGB 2WIHB 1GY3B 4EC9B 2R7GA 2CCIB 2CCHB 4HL4A 3VKHA 4G6LB 4OB1B 3TW6A 2KMGA 4CFXB 2UZLB 1F5QB 2IW9B 2WPAB 2W9FA 1G3NC 4BCKB 2QGSA 1BU2A 4BBSM 4OB0B 5HBHB 5ICPB 2CZ0B 2EUFA 4MFEA 1H28B 3BLQB 3BHTB 1GH6B 4EONB 4QSHA 3MI9B 3TNIB 3H4CA 4BCGB 5HBJB 3EOCB 5EJCA 1H4LD 1VINA 2C4GB 3EJ1B 3B57A 2DMEA 2IN3A 1AD6A 3WVDB 4II5B 4KRDB 5CYIB 3DJBA 4F6UB 4BY1X 3HB9A 4OB2B 1H1PB 4F7NB 5EFQB 4CXAB 1H26B 4ELJA 2W96A 4EOPB 1TFBA 4CFMB 3A8OB 3NDQA 2C5OB 1OL1B 4ROEA 2DD4B 3X28B 2AHJB 3BHUB 2KR6A 2JGZB 5HVYB 1P5EB 1E9HB 2LW4A 5HBEB 1O9KA 3F5XB 2CYZB 5IHYA 1QLBA 4UN0A 4EOSB 3PO3S 3QHWB 4Z6YA 4BCPB 4ROCA 4CFVB 2G9XB 2IVXA 5I5ZB 2CZ6B 3BLHB 5DQVA 4IMYB 5BNJB 5IDNB 2PHGA 3BG9A
chains in the Genus database with same CATH topology
2PK2A 3BLQB 4EOJB 3LQ5B 3BHTB 1GH6B 1AISB 1O9KB 2C5NB 5LQFB 4EONB 3MY5B 3O0GD 2UZBB 1QMZB 4F7LB 1N4MA 4RODA 2W2HA 3MI9B 5HQ0B 1D3UB 3TNIB 3H4CA 4BCGB 4BCMB 4CFNB 5L2WB 4BCQD 4YC3B 1VYWB 1FVVB 4CFUD 5HBJB 5FGKB 3TN8B 3EOCB 1OKWB 2QDJA 4BCQB 4EOIB 4CFUB 1JOWA 3TNWB 2WFYB 4YOZA 3DDQB 2IW8B 1H4LD 1VINA 2IW6B 1ZP2A 1OIUB 2C4GB 1H1RB 1GUXB 3EJ1B 1OL2B 4OR5B 4EOLB 4F70B 1JSUB 1AD6A 5LMKB 1XO2A 1JKWA 3POMA 4II5B 4KRDB 2F2CA 4BCMD 1H24B 5CYIB 2BKZB 5CEIB 4F6UB 2PK9B 3TNHB 4KRCB 2I40B 1H1PB 4F7NB 5EFQB 4CXAB 4F7SB 4NSTB 1H26B 3BLRB 4EORB 4ELJA 3K7AM 2UZEB 4BCND 2W96A 2WMBB 1UNLD 4EOMB 1UNGD 3MIAB 3MY1B 2I53A 3BHVB 4BCIB 4ELLA 2WMAB 4CFWB 4BCNB 4EOPB 1TFBA 4CFMB 1KXUA 2UZDB 2B9RA 4YOSA 1JSTB 3G33B 2C5OB 1H1SB 2WXVB 1OIYB 4OGRB 1OI9B 1OL1B 1OKVB 2CJMB 4ROEA 4YOOA 2WIPB 1PKDB 1H25B 3BHUB 4BCHB 4EOOB 2JGZB 4EOQB 2X1NB 2C6TB 4EOKB 5HVYB 3EIDB 4F6WB 2WEVB 5ACBA 1URCB 5IDPB 1FINB 2BPMB 1P5EB 3RGFB 4BCFB 2V22B 1E9HB 5HBEB 1C9BA 1O9KA 2WIHB 1GY3B 3F5XB 2R7GA 4CRLB 4EC9B 4F7JB 2CCIB 4BCOB 2CCHB 2C5XB 4Y72B 4UN0A 4EOSB 2WHBB 3QHWB 4G6LB 4BCPB 4I3ZB 1H27B 4CFXB 4ROCA 1H1QB 2UZLB 4TTHA 1F5QB 2IW9B 2WPAB 2W9FA 5IF1B 2W9ZA 5HNBB 1G3NC 4CFVB 4BCKB 2G9XB 2C5VB 2IVXA 1VOLA 1OGUB 1GUXA 1BU2A 3DDPB 4FX3B 5I5ZB 3BLHB 4EC8B 2UUEB 3DOGB 2PMIB 4IMYB 4F6SB 3QHRB 5BNJB 4BCJB 2W99A 5HBHB 3M03A 5ICPB 2EUFA 5IDNB 1UNHD 2PHGA 1H28B 1W98B
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2PK2 A;  3BLQ B;  4EOJ B;  3LQ5 B;  3BHT B;  1GH6 B;  1AIS B;  1O9K B;  2C5N B;  5LQF B;  4EON B;  3MY5 B;  3O0G D;  2UZB B;  1QMZ B;  4F7L B;  1N4M A;  4ROD A;  2W2H A;  3MI9 B;  5HQ0 B;  1D3U B;  3TNI B;  3H4C A;  4BCG B;  4BCM B;  4CFN B;  5L2W B;  4BCQ D;  4YC3 B;  1VYW B;  1FVV B;  4CFU D;  5HBJ B;  5FGK B;  3TN8 B;  3EOC B;  1OKW B;  2QDJ A;  4BCQ B;  4EOI B;  4CFU B;  1JOW A;  3TNW B;  2WFY B;  4YOZ A;  3DDQ B;  2IW8 B;  1H4L D;  1VIN A;  2IW6 B;  1ZP2 A;  1OIU B;  2C4G B;  1H1R B;  1GUX B;  3EJ1 B;  1OL2 B;  4OR5 B;  4EOL B;  4F70 B;  1JSU B;  1AD6 A;  5LMK B;  1XO2 A;  1JKW A;  3POM A;  4II5 B;  4KRD B;  2F2C A;  4BCM D;  1H24 B;  5CYI B;  2BKZ B;  5CEI B;  4F6U B;  2PK9 B;  3TNH B;  4KRC B;  2I40 B;  1H1P B;  4F7N B;  5EFQ B;  4CXA B;  4F7S B;  4NST B;  1H26 B;  3BLR B;  4EOR B;  4ELJ A;  3K7A M;  2UZE B;  4BCN D;  2W96 A;  2WMB B;  1UNL D;  4EOM B;  1UNG D;  3MIA B;  3MY1 B;  2I53 A;  3BHV B;  4BCI B;  4ELL A;  2WMA B;  4CFW B;  4BCN B;  4EOP B;  1TFB A;  4CFM B;  1KXU A;  2UZD B;  2B9R A;  4YOS A;  1JST B;  3G33 B;  2C5O B;  1H1S B;  2WXV B;  1OIY B;  4OGR B;  1OI9 B;  1OL1 B;  1OKV B;  2CJM B;  4ROE A;  4YOO A;  2WIP B;  1PKD B;  1H25 B;  3BHU B;  4BCH B;  4EOO B;  2JGZ B;  4EOQ B;  2X1N B;  2C6T B;  4EOK B;  5HVY B;  3EID B;  4F6W B;  2WEV B;  5ACB A;  1URC B;  5IDP B;  1FIN B;  2BPM B;  1P5E B;  3RGF B;  4BCF B;  2V22 B;  1E9H B;  5HBE B;  1C9B A;  1O9K A;  2WIH B;  1GY3 B;  3F5X B;  2R7G A;  4CRL B;  4EC9 B;  4F7J B;  2CCI B;  4BCO B;  2CCH B;  2C5X B;  4Y72 B;  4UN0 A;  4EOS B;  2WHB B;  3QHW B;  4G6L B;  4BCP B;  4I3Z B;  1H27 B;  4CFX B;  4ROC A;  1H1Q B;  2UZL B;  4TTH A;  1F5Q B;  2IW9 B;  2WPA B;  2W9F A;  5IF1 B;  2W9Z A;  5HNB B;  1G3N C;  4CFV B;  4BCK B;  2G9X B;  2C5V B;  2IVX A;  1VOL A;  1OGU B;  1GUX A;  1BU2 A;  3DDP B;  4FX3 B;  5I5Z B;  3BLH B;  4EC8 B;  2UUE B;  3DOG B;  2PMI B;  4IMY B;  4F6S B;  3QHR B;  5BNJ B;  4BCJ B;  2W99 A;  5HBH B;  3M03 A;  5ICP B;  2EUF A;  5IDN B;  1UNH D;  2PHG A;  1H28 B;  1W98 B; 
#chains in the Genus database with same CATH topology
 3LQ5 B;  1IRE B;  5LQF B;  2D0Q B;  1QMZ B;  2DXC B;  2W2H A;  4NC6 A;  2ZPG B;  2BS2 A;  2ZPB B;  4BCQ D;  1OKW B;  4BCQ B;  4HNU A;  3TNW B;  2ZPF B;  4OB3 B;  4JX6 A;  4OR5 B;  1H1R B;  1GUX B;  3QYE A;  4F70 B;  4AI6 A;  5LMK B;  3POM A;  2F2C A;  4AKI A;  3A8M B;  3BLR B;  3K7A M;  4BCN D;  1UNL D;  4EOM B;  1UNG D;  3KHI A;  3MIA B;  4BCI B;  3WVE B;  4CFW B;  4BCN B;  2QFZ A;  2QQ8 A;  2B9R A;  3BG3 A;  1JST B;  3X25 B;  1OI9 B;  2WIP B;  2ZZD B;  3X26 B;  4BCH B;  3QYB A;  4EOK B;  4F6W B;  1TD6 A;  3QZ5 B;  4BCF B;  1V29 B;  4CRL B;  4F7J B;  1UGQ B;  4BCO B;  2C5X B;  4I3Z B;  3DTO A;  3HHT B;  1UGR B;  4TTH A;  5DQW A;  4BXX X;  2W9Z A;  5HNB B;  2C5V B;  4EC8 B;  4AKG A;  2UUE B;  3DOG B;  3QYH B;  3M03 A;  1UNH D;  2ZPI B;  2PK2 A;  4EOJ B;  4JX4 A;  4M6V A;  3QZ9 B;  1AIS B;  2C5N B;  3A8L B;  3MY5 B;  3VYG B;  3QWL A;  1D3U B;  4BCM B;  2BS3 A;  4CFN B;  4CFU D;  5FGK B;  3TN8 B;  2QDJ A;  4CFU B;  3A8G B;  4YOZ A;  2IW8 B;  4EOL B;  1OIU B;  3VKG A;  1OL2 B;  1JSU B;  1JKW A;  5CEI B;  2PK9 B;  3TNH B;  4KRC B;  4F7S B;  4EOR B;  4HLQ A;  2WMB B;  3A8H B;  4JX5 A;  1FKM A;  2BS4 A;  2I53 A;  3BHV B;  3TW7 A;  4ZGJ B;  3GTM S;  3G33 B;  4FM4 B;  4OGR B;  2CJM B;  2DD5 B;  4YOO A;  1H25 B;  4EOO B;  2PJQ A;  3X24 B;  2WEV B;  5ACB A;  5IDP B;  1FIN B;  1E7P A;  1C9B A;  4HNV A;  3HZJ A;  4Y72 B;  2DPP B;  2WHB B;  1H27 B;  3HBL A;  1H1Q B;  3BG5 A;  2ZCF B;  2ZPE B;  5IF1 B;  4ZGD B;  1VOL A;  1OGU B;  1GUX A;  3DDP B;  1UGP B;  4FX3 B;  4BY7 X;  2PMI B;  4F6S B;  3QHR B;  4BCJ B;  2W99 A;  2ZPH B;  1W98 B;  1O9K B;  3O0G D;  2UZB B;  4F7L B;  1N4M A;  3X20 B;  4ROD A;  5HQ0 B;  5L2W B;  4YC3 B;  1VYW B;  1FVV B;  3QXE B;  2WJ9 A;  4EOI B;  1JOW A;  4LOC A;  2WFY B;  2CZ7 B;  3DDQ B;  1ZP2 A;  2G77 A;  2IW6 B;  4BBR M;  1UGS B;  1AHJ B;  1XO2 A;  4BCM D;  1H24 B;  2BKZ B;  4MFD A;  2I40 B;  4MIM A;  4NST B;  2UZE B;  4HNT A;  3DL1 A;  3MY1 B;  4ELL A;  2WMA B;  2QF7 A;  3VYH B;  1KXU A;  2UZD B;  4YOS A;  4AKH A;  1H1S B;  2CZ1 B;  2WXV B;  1OIY B;  1OKV B;  2QDY B;  1PKD B;  4ZGE B;  2DXB B;  4EOQ B;  2X1N B;  2C6T B;  3EID B;  1URC B;  2BPM B;  1ENW A;  3RGF B;  2V22 B;  3HO8 A;  3QYG B;  2WIH B;  1GY3 B;  4EC9 B;  2R7G A;  2CCI B;  2CCH B;  4HL4 A;  3VKH A;  4G6L B;  4OB1 B;  3TW6 A;  2KMG A;  4CFX B;  2UZL B;  1F5Q B;  2IW9 B;  2WPA B;  2W9F A;  1G3N C;  4BCK B;  2QGS A;  1BU2 A;  4BBS M;  4OB0 B;  5HBH B;  5ICP B;  2CZ0 B;  2EUF A;  4MFE A;  1H28 B;  3BLQ B;  3BHT B;  1GH6 B;  4EON B;  4QSH A;  3MI9 B;  3TNI B;  3H4C A;  4BCG B;  5HBJ B;  3EOC B;  5EJC A;  1H4L D;  1VIN A;  2C4G B;  3EJ1 B;  3B57 A;  2DME A;  2IN3 A;  1AD6 A;  3WVD B;  4II5 B;  4KRD B;  5CYI B;  3DJB A;  4F6U B;  4BY1 X;  3HB9 A;  4OB2 B;  1H1P B;  4F7N B;  5EFQ B;  4CXA B;  1H26 B;  4ELJ A;  2W96 A;  4EOP B;  1TFB A;  4CFM B;  3A8O B;  3NDQ A;  2C5O B;  1OL1 B;  4ROE A;  2DD4 B;  3X28 B;  2AHJ B;  3BHU B;  2KR6 A;  2JGZ B;  5HVY B;  1P5E B;  1E9H B;  2LW4 A;  5HBE B;  1O9K A;  3F5X B;  2CYZ B;  5IHY A;  1QLB A;  4UN0 A;  4EOS B;  3PO3 S;  3QHW B;  4Z6Y A;  4BCP B;  4ROC A;  4CFV B;  2G9X B;  2IVX A;  5I5Z B;  2CZ6 B;  3BLH B;  5DQV A;  4IMY B;  5BNJ B;  5IDN B;  2PHG A;  3BG9 A; 
#chains in the Genus database with same CATH homology
 2PK2 A;  3BLQ B;  4EOJ B;  3LQ5 B;  3BHT B;  1GH6 B;  1AIS B;  1O9K B;  2C5N B;  5LQF B;  4EON B;  3MY5 B;  3O0G D;  2UZB B;  1QMZ B;  4F7L B;  1N4M A;  4ROD A;  2W2H A;  3MI9 B;  5HQ0 B;  1D3U B;  3TNI B;  3H4C A;  4BCG B;  4BCM B;  4CFN B;  5L2W B;  4BCQ D;  4YC3 B;  1VYW B;  1FVV B;  4CFU D;  5HBJ B;  5FGK B;  3TN8 B;  3EOC B;  1OKW B;  2QDJ A;  4BCQ B;  4EOI B;  4CFU B;  1JOW A;  3TNW B;  2WFY B;  4YOZ A;  3DDQ B;  2IW8 B;  1H4L D;  1VIN A;  2IW6 B;  1ZP2 A;  1OIU B;  2C4G B;  1H1R B;  1GUX B;  3EJ1 B;  1OL2 B;  4OR5 B;  4EOL B;  4F70 B;  1JSU B;  1AD6 A;  5LMK B;  1XO2 A;  1JKW A;  3POM A;  4II5 B;  4KRD B;  2F2C A;  4BCM D;  1H24 B;  5CYI B;  2BKZ B;  5CEI B;  4F6U B;  2PK9 B;  3TNH B;  4KRC B;  2I40 B;  1H1P B;  4F7N B;  5EFQ B;  4CXA B;  4F7S B;  4NST B;  1H26 B;  3BLR B;  4EOR B;  4ELJ A;  3K7A M;  2UZE B;  4BCN D;  2W96 A;  2WMB B;  1UNL D;  4EOM B;  1UNG D;  3MIA B;  3MY1 B;  2I53 A;  3BHV B;  4BCI B;  4ELL A;  2WMA B;  4CFW B;  4BCN B;  4EOP B;  1TFB A;  4CFM B;  1KXU A;  2UZD B;  2B9R A;  4YOS A;  1JST B;  3G33 B;  2C5O B;  1H1S B;  2WXV B;  1OIY B;  4OGR B;  1OI9 B;  1OL1 B;  1OKV B;  2CJM B;  4ROE A;  4YOO A;  2WIP B;  1PKD B;  1H25 B;  3BHU B;  4BCH B;  4EOO B;  2JGZ B;  4EOQ B;  2X1N B;  2C6T B;  4EOK B;  5HVY B;  3EID B;  4F6W B;  2WEV B;  5ACB A;  1URC B;  5IDP B;  1FIN B;  2BPM B;  1P5E B;  3RGF B;  4BCF B;  2V22 B;  1E9H B;  5HBE B;  1C9B A;  1O9K A;  2WIH B;  1GY3 B;  3F5X B;  2R7G A;  4CRL B;  4EC9 B;  4F7J B;  2CCI B;  4BCO B;  2CCH B;  2C5X B;  4Y72 B;  4UN0 A;  4EOS B;  2WHB B;  3QHW B;  4G6L B;  4BCP B;  4I3Z B;  1H27 B;  4CFX B;  4ROC A;  1H1Q B;  2UZL B;  4TTH A;  1F5Q B;  2IW9 B;  2WPA B;  2W9F A;  5IF1 B;  2W9Z A;  5HNB B;  1G3N C;  4CFV B;  4BCK B;  2G9X B;  2C5V B;  2IVX A;  1VOL A;  1OGU B;  1GUX A;  1BU2 A;  3DDP B;  4FX3 B;  5I5Z B;  3BLH B;  4EC8 B;  2UUE B;  3DOG B;  2PMI B;  4IMY B;  4F6S B;  3QHR B;  5BNJ B;  4BCJ B;  2W99 A;  5HBH B;  3M03 A;  5ICP B;  2EUF A;  5IDN B;  1UNH D;  2PHG A;  1H28 B;  1W98 B;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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