4EY8B

Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of human acetylcholinesterase in complex with pharmacologically important ligands.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Acetylcholinesterase
total genus 10
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2012-05-01
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4ey8B00
1PLOA 1FRAA 1KBSA 1TXBA 1CXOA 1LXHA 2UX2A 1FF4A 2QJ9C 2CDXA 2MUOA 3NH7A 2H62D 3VTSA 3EBXA 2JVEA 1BXPA 1ABTA 1FSSB 1XT3A 1F94A 1H0JA 1CODA 1MAHF 3KFDI 1TXAA 1IK8A 1V6PA 1CRFA 2MFAA 4XJJA 1JE9A 4FAOC 1IDLA 2PJYB 2CCXA 4FAOE 1LXGA 2BHIA 1JBDA 1KS6A 2ERAA 2NBTA 2H7ZB 1F8UB 2BTXA 2VLWA 1KFHA 1HOYA 4QTIU 1KC4A 1UG4A 2QJAC 1IKCA 2I9BE 3KFDE 1FFJA 3ERAA 3U73U 1CVOA 3FEVA 1JGKA 1FSCA 2HLRA 2J8BA 5IMYC 1YWHA 1KBTA 2L03A 5EBXA 2H64C 2GOOC 1NTNA 3NEQA 2JQPA 4BIKB 2CRSA 4HQPF 1TGXA 1S4YA 2MJYA 1IDGA 2MJ4A 1IDIA 4AEAA 1M9ZA 1ONJA 3BT1U 3LAQU 5IMTD 1KXIA 1ERAA 2CTXA 3QB4B 1LJZA 2H5FA 5DU1A 2FD6U 2MJ0A 2HLQA 1CCQA 1RGJA 1CHVS 3U74U 1CREA 1L4WA 3NDSA 2H64B 1LX5B 2GOOB 2MHYA 2H7ZA 1LSIA 2L5SA 1VB0A 1QKDA 3BT2U 1HAAA 4P7UA 1IDHA 1BTEA 4IYEA 1DRSA 1NEAA 2QC1A 4DO8A 1REWC 2CRTA 1HAJA 1HC9B 1ES7B 4BDTB 2N99A 4ZQYA 2H8UA 2LCRA 1B41B 1TFSA 1ZADA 4LFTA 1CDRA 1FASA 2OFSA 2QJBC 1MR6A 6EBXA 2K3GA 3HH7A 1NYSA 1CXNA 2LA1A 3PLCA 1W6BA 4OM4A 1CTXA 1NORA 5DZ5A 1CDSA 1COEA 1ERGA 4RUDA 1KU6B 1CDTA 1RL5A 1CDQA 1IQ9A 5DO6A 1CB9A 2MUPA 1IJCA 1NYUA 1NXBA 1I02A 1HC9A 1G6MA 1KBAA 1NTXA 2UWRA 1QKEA 2X8BB 1KL8A 2PJYC 3EVSC 4EY8B 1KTZB 1QM7A 2H62C 4UY2C 2ABXA 4OM5A
chains in the Genus database with same CATH superfamily
1PLOA 1FRAA 1KBSA 1TXBA 1CXOA 1LXHA 2UX2A 1FF4A 2QJ9C 2CDXA 2MUOA 3NH7A 2H62D 3VTSA 3EBXA 2JVEA 1BXPA 1ABTA 1FSSB 1XT3A 1F94A 1H0JA 1CODA 1MAHF 3KFDI 1TXAA 1IK8A 1V6PA 1CRFA 2MFAA 4XJJA 1JE9A 4FAOC 1IDLA 2PJYB 2CCXA 4FAOE 1LXGA 2BHIA 1JBDA 1KS6A 2ERAA 2NBTA 2H7ZB 1F8UB 2BTXA 2VLWA 1KFHA 1HOYA 4QTIU 1KC4A 1UG4A 2QJAC 1IKCA 2I9BE 3KFDE 1FFJA 3ERAA 3U73U 1CVOA 3FEVA 1JGKA 1FSCA 2HLRA 2J8BA 5IMYC 1YWHA 1KBTA 2L03A 5EBXA 2H64C 2GOOC 1NTNA 3NEQA 2JQPA 4BIKB 2CRSA 4HQPF 1TGXA 1S4YA 2MJYA 1IDGA 2MJ4A 1IDIA 4AEAA 1M9ZA 1ONJA 3BT1U 3LAQU 5IMTD 1KXIA 1ERAA 2CTXA 3QB4B 1LJZA 2H5FA 5DU1A 2FD6U 2MJ0A 2HLQA 1CCQA 1RGJA 1CHVS 3U74U 1CREA 1L4WA 3NDSA 2H64B 1LX5B 2GOOB 2MHYA 2H7ZA 1LSIA 2L5SA 1VB0A 1QKDA 3BT2U 1HAAA 4P7UA 1IDHA 1BTEA 4IYEA 1DRSA 1NEAA 2QC1A 4DO8A 1REWC 2CRTA 1HAJA 1HC9B 1ES7B 4BDTB 2N99A 4ZQYA 2H8UA 2LCRA 1B41B 1TFSA 1ZADA 4LFTA 1CDRA 1FASA 2OFSA 2QJBC 1MR6A 6EBXA 2K3GA 3HH7A 1NYSA 1CXNA 2LA1A 3PLCA 1W6BA 4OM4A 1CTXA 1NORA 5DZ5A 1CDSA 1COEA 1ERGA 4RUDA 1KU6B 1CDTA 1RL5A 1CDQA 1IQ9A 5DO6A 1CB9A 2MUPA 1IJCA 1NYUA 1NXBA 1I02A 1HC9A 1G6MA 1KBAA 1NTXA 2UWRA 1QKEA 2X8BB 1KL8A 2PJYC 3EVSC 4KSNA 4EY8B 1KTZB 1QM7A 2H62C 4UY2C 2ABXA 4OM5A
chains in the Genus database with same CATH topology
1PLOA 1FRAA 1KBSA 1TXBA 1CXOA 1LXHA 2UX2A 1FF4A 2QJ9C 2CDXA 2MUOA 3NH7A 2H62D 3VTSA 3EBXA 2JVEA 1BXPA 1ABTA 1FSSB 1XT3A 1F94A 1H0JA 1CODA 1MAHF 3KFDI 1TXAA 1IK8A 1V6PA 1CRFA 2MFAA 4XJJA 1JE9A 4FAOC 1IDLA 2PJYB 2CCXA 4FAOE 1LXGA 2BHIA 1JBDA 1KS6A 2ERAA 2NBTA 2H7ZB 1F8UB 2BTXA 2VLWA 1KFHA 1HOYA 4QTIU 1KC4A 1UG4A 2QJAC 1IKCA 2I9BE 3KFDE 1FFJA 3ERAA 3U73U 1CVOA 3FEVA 1JGKA 1FSCA 2HLRA 2J8BA 5IMYC 1YWHA 1KBTA 2L03A 5EBXA 2H64C 2GOOC 1NTNA 3NEQA 2JQPA 4BIKB 2CRSA 4HQPF 1TGXA 1S4YA 2MJYA 1IDGA 2MJ4A 1IDIA 4AEAA 1M9ZA 1ONJA 3BT1U 3LAQU 5IMTD 1KXIA 1ERAA 2CTXA 3QB4B 1LJZA 2H5FA 5DU1A 2FD6U 2MJ0A 2HLQA 1CCQA 1RGJA 1CHVS 3U74U 1CREA 1L4WA 3NDSA 2H64B 1LX5B 2GOOB 2MHYA 2H7ZA 1LSIA 2L5SA 1VB0A 1QKDA 3BT2U 1HAAA 4P7UA 1IDHA 1BTEA 4IYEA 1DRSA 1NEAA 2QC1A 4DO8A 1REWC 2CRTA 1HAJA 1HC9B 1ES7B 4BDTB 2N99A 4ZQYA 2H8UA 2LCRA 1B41B 1TFSA 1ZADA 4LFTA 1CDRA 1FASA 2OFSA 2QJBC 1MR6A 6EBXA 2K3GA 3HH7A 1NYSA 1CXNA 2LA1A 3PLCA 1W6BA 4OM4A 1CTXA 1NORA 5DZ5A 1CDSA 1COEA 1ERGA 4RUDA 1KU6B 1CDTA 1RL5A 1CDQA 1IQ9A 5DO6A 1CB9A 2MUPA 1IJCA 1NYUA 1NXBA 1I02A 1HC9A 1G6MA 1KBAA 1NTXA 2UWRA 1QKEA 2X8BB 1KL8A 2PJYC 3EVSC 4KSNA 4EY8B 1KTZB 1QM7A 2H62C 4UY2C 2ABXA 4OM5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PLO A;  1FRA A;  1KBS A;  1TXB A;  1CXO A;  1LXH A;  2UX2 A;  1FF4 A;  2QJ9 C;  2CDX A;  2MUO A;  3NH7 A;  2H62 D;  3VTS A;  3EBX A;  2JVE A;  1BXP A;  1ABT A;  1FSS B;  1XT3 A;  1F94 A;  1H0J A;  1COD A;  1MAH F;  3KFD I;  1TXA A;  1IK8 A;  1V6P A;  1CRF A;  2MFA A;  4XJJ A;  1JE9 A;  4FAO C;  1IDL A;  2PJY B;  2CCX A;  4FAO E;  1LXG A;  2BHI A;  1JBD A;  1KS6 A;  2ERA A;  2NBT A;  2H7Z B;  1F8U B;  2BTX A;  2VLW A;  1KFH A;  1HOY A;  4QTI U;  1KC4 A;  1UG4 A;  2QJA C;  1IKC A;  2I9B E;  3KFD E;  1FFJ A;  3ERA A;  3U73 U;  1CVO A;  3FEV A;  1JGK A;  1FSC A;  2HLR A;  2J8B A;  5IMY C;  1YWH A;  1KBT A;  2L03 A;  5EBX A;  2H64 C;  2GOO C;  1NTN A;  3NEQ A;  2JQP A;  4BIK B;  2CRS A;  4HQP F;  1TGX A;  1S4Y A;  2MJY A;  1IDG A;  2MJ4 A;  1IDI A;  4AEA A;  1M9Z A;  1ONJ A;  3BT1 U;  3LAQ U;  5IMT D;  1KXI A;  1ERA A;  2CTX A;  3QB4 B;  1LJZ A;  2H5F A;  5DU1 A;  2FD6 U;  2MJ0 A;  2HLQ A;  1CCQ A;  1RGJ A;  1CHV S;  3U74 U;  1CRE A;  1L4W A;  3NDS A;  2H64 B;  1LX5 B;  2GOO B;  2MHY A;  2H7Z A;  1LSI A;  2L5S A;  1VB0 A;  1QKD A;  3BT2 U;  1HAA A;  4P7U A;  1IDH A;  1BTE A;  4IYE A;  1DRS A;  1NEA A;  2QC1 A;  4DO8 A;  1REW C;  2CRT A;  1HAJ A;  1HC9 B;  1ES7 B;  4BDT B;  2N99 A;  4ZQY A;  2H8U A;  2LCR A;  1B41 B;  1TFS A;  1ZAD A;  4LFT A;  1CDR A;  1FAS A;  2OFS A;  2QJB C;  1MR6 A;  6EBX A;  2K3G A;  3HH7 A;  1NYS A;  1CXN A;  2LA1 A;  3PLC A;  1W6B A;  4OM4 A;  1CTX A;  1NOR A;  5DZ5 A;  1CDS A;  1COE A;  1ERG A;  4RUD A;  1KU6 B;  1CDT A;  1RL5 A;  1CDQ A;  1IQ9 A;  5DO6 A;  1CB9 A;  2MUP A;  1IJC A;  1NYU A;  1NXB A;  1I02 A;  1HC9 A;  1G6M A;  1KBA A;  1NTX A;  2UWR A;  1QKE A;  2X8B B;  1KL8 A;  2PJY C;  3EVS C;  4EY8 B;  1KTZ B;  1QM7 A;  2H62 C;  4UY2 C;  2ABX A;  4OM5 A; 
#chains in the Genus database with same CATH topology
 1PLO A;  1FRA A;  1KBS A;  1TXB A;  1CXO A;  1LXH A;  2UX2 A;  1FF4 A;  2QJ9 C;  2CDX A;  2MUO A;  3NH7 A;  2H62 D;  3VTS A;  3EBX A;  2JVE A;  1BXP A;  1ABT A;  1FSS B;  1XT3 A;  1F94 A;  1H0J A;  1COD A;  1MAH F;  3KFD I;  1TXA A;  1IK8 A;  1V6P A;  1CRF A;  2MFA A;  4XJJ A;  1JE9 A;  4FAO C;  1IDL A;  2PJY B;  2CCX A;  4FAO E;  1LXG A;  2BHI A;  1JBD A;  1KS6 A;  2ERA A;  2NBT A;  2H7Z B;  1F8U B;  2BTX A;  2VLW A;  1KFH A;  1HOY A;  4QTI U;  1KC4 A;  1UG4 A;  2QJA C;  1IKC A;  2I9B E;  3KFD E;  1FFJ A;  3ERA A;  3U73 U;  1CVO A;  3FEV A;  1JGK A;  1FSC A;  2HLR A;  2J8B A;  5IMY C;  1YWH A;  1KBT A;  2L03 A;  5EBX A;  2H64 C;  2GOO C;  1NTN A;  3NEQ A;  2JQP A;  4BIK B;  2CRS A;  4HQP F;  1TGX A;  1S4Y A;  2MJY A;  1IDG A;  2MJ4 A;  1IDI A;  4AEA A;  1M9Z A;  1ONJ A;  3BT1 U;  3LAQ U;  5IMT D;  1KXI A;  1ERA A;  2CTX A;  3QB4 B;  1LJZ A;  2H5F A;  5DU1 A;  2FD6 U;  2MJ0 A;  2HLQ A;  1CCQ A;  1RGJ A;  1CHV S;  3U74 U;  1CRE A;  1L4W A;  3NDS A;  2H64 B;  1LX5 B;  2GOO B;  2MHY A;  2H7Z A;  1LSI A;  2L5S A;  1VB0 A;  1QKD A;  3BT2 U;  1HAA A;  4P7U A;  1IDH A;  1BTE A;  4IYE A;  1DRS A;  1NEA A;  2QC1 A;  4DO8 A;  1REW C;  2CRT A;  1HAJ A;  1HC9 B;  1ES7 B;  4BDT B;  2N99 A;  4ZQY A;  2H8U A;  2LCR A;  1B41 B;  1TFS A;  1ZAD A;  4LFT A;  1CDR A;  1FAS A;  2OFS A;  2QJB C;  1MR6 A;  6EBX A;  2K3G A;  3HH7 A;  1NYS A;  1CXN A;  2LA1 A;  3PLC A;  1W6B A;  4OM4 A;  1CTX A;  1NOR A;  5DZ5 A;  1CDS A;  1COE A;  1ERG A;  4RUD A;  1KU6 B;  1CDT A;  1RL5 A;  1CDQ A;  1IQ9 A;  5DO6 A;  1CB9 A;  2MUP A;  1IJC A;  1NYU A;  1NXB A;  1I02 A;  1HC9 A;  1G6M A;  1KBA A;  1NTX A;  2UWR A;  1QKE A;  2X8B B;  1KL8 A;  2PJY C;  3EVS C;  4KSN A;  4EY8 B;  1KTZ B;  1QM7 A;  2H62 C;  4UY2 C;  2ABX A;  4OM5 A; 
#chains in the Genus database with same CATH homology
 1PLO A;  1FRA A;  1KBS A;  1TXB A;  1CXO A;  1LXH A;  2UX2 A;  1FF4 A;  2QJ9 C;  2CDX A;  2MUO A;  3NH7 A;  2H62 D;  3VTS A;  3EBX A;  2JVE A;  1BXP A;  1ABT A;  1FSS B;  1XT3 A;  1F94 A;  1H0J A;  1COD A;  1MAH F;  3KFD I;  1TXA A;  1IK8 A;  1V6P A;  1CRF A;  2MFA A;  4XJJ A;  1JE9 A;  4FAO C;  1IDL A;  2PJY B;  2CCX A;  4FAO E;  1LXG A;  2BHI A;  1JBD A;  1KS6 A;  2ERA A;  2NBT A;  2H7Z B;  1F8U B;  2BTX A;  2VLW A;  1KFH A;  1HOY A;  4QTI U;  1KC4 A;  1UG4 A;  2QJA C;  1IKC A;  2I9B E;  3KFD E;  1FFJ A;  3ERA A;  3U73 U;  1CVO A;  3FEV A;  1JGK A;  1FSC A;  2HLR A;  2J8B A;  5IMY C;  1YWH A;  1KBT A;  2L03 A;  5EBX A;  2H64 C;  2GOO C;  1NTN A;  3NEQ A;  2JQP A;  4BIK B;  2CRS A;  4HQP F;  1TGX A;  1S4Y A;  2MJY A;  1IDG A;  2MJ4 A;  1IDI A;  4AEA A;  1M9Z A;  1ONJ A;  3BT1 U;  3LAQ U;  5IMT D;  1KXI A;  1ERA A;  2CTX A;  3QB4 B;  1LJZ A;  2H5F A;  5DU1 A;  2FD6 U;  2MJ0 A;  2HLQ A;  1CCQ A;  1RGJ A;  1CHV S;  3U74 U;  1CRE A;  1L4W A;  3NDS A;  2H64 B;  1LX5 B;  2GOO B;  2MHY A;  2H7Z A;  1LSI A;  2L5S A;  1VB0 A;  1QKD A;  3BT2 U;  1HAA A;  4P7U A;  1IDH A;  1BTE A;  4IYE A;  1DRS A;  1NEA A;  2QC1 A;  4DO8 A;  1REW C;  2CRT A;  1HAJ A;  1HC9 B;  1ES7 B;  4BDT B;  2N99 A;  4ZQY A;  2H8U A;  2LCR A;  1B41 B;  1TFS A;  1ZAD A;  4LFT A;  1CDR A;  1FAS A;  2OFS A;  2QJB C;  1MR6 A;  6EBX A;  2K3G A;  3HH7 A;  1NYS A;  1CXN A;  2LA1 A;  3PLC A;  1W6B A;  4OM4 A;  1CTX A;  1NOR A;  5DZ5 A;  1CDS A;  1COE A;  1ERG A;  4RUD A;  1KU6 B;  1CDT A;  1RL5 A;  1CDQ A;  1IQ9 A;  5DO6 A;  1CB9 A;  2MUP A;  1IJC A;  1NYU A;  1NXB A;  1I02 A;  1HC9 A;  1G6M A;  1KBA A;  1NTX A;  2UWR A;  1QKE A;  2X8B B;  1KL8 A;  2PJY C;  3EVS C;  4KSN A;  4EY8 B;  1KTZ B;  1QM7 A;  2H62 C;  4UY2 C;  2ABX A;  4OM5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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