4EY8B

Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Acetylcholinesterase
publication title Structures of human acetylcholinesterase in complex with pharmacologically important ligands.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase inhibitor
total genus 10
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2012-05-01
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4ey8B00
2QC1A 2FD6U 4P7UA 5IMTD 2H7ZA 1F94A 1KBAA 1NTXA 1LX5B 1FF4A 1ONJA 4LFTA 3ERAA 1LXHA 1IJCA 3VTSA 1HC9A 3KFDI 1REWC 1NTNA 1NYUA 2H7ZB 3FEVA 1KC4A 1B41B 1CTXA 1RL5A 3HH7A 1HOYA 1MR6A 2GOOC 1HAAA 3EBXA 1QKEA 2BHIA 3PLCA 1H0JA 2CRSA 2L5SA 2MHYA 2QJ9C 3U74U 1NXBA 1MAHF 1ES7B 5DZ5A 1LSIA 2GOOB 1CVOA 2CDXA 1RGJA 1JBDA 1KL8A 1KFHA 2K3GA 2H5FA 4QTIU 4BDTB 1FRAA 2QJAC 4RUDA 1KU6B 2ABXA 2JQPA 2I9BE 3QB4B 6EBXA 2MFAA 1L4WA 1CREA 2CTXA 4HQPF 4DO8A 2CRTA 1M9ZA 2X8BB 2J8BA 2JVEA 1IDGA 4BIKB 3U73U 1W6BA 1KS6A 2H62D 1CDQA 1FFJA 3BT1U 2PJYC 1CB9A 2LCRA 1TFSA 1KBTA 1HC9B 1TXAA 1DRSA 3NH7A 5DO6A 1LJZA 1PLOA 2H64C 2UX2A 1KTZB 1XT3A 2HLQA 1IDLA 1QKDA 2HLRA 2PJYB 4OM5A 1CDRA 1TGXA 1CDTA 3KFDE 1ABTA 2H64B 1CRFA 1IDHA 1V6PA 2NBTA 4AEAA 4FAOE 1NYSA 1I02A 1TXBA 5EBXA 3NEQA 1ZADA 2LA1A 1KBSA 2MUPA 1IKCA 1F8UB 1UG4A 1IDIA 4ZQYA 2MJYA 2OFSA 4EY8B 1JE9A 2VLWA 1YWHA 1BXPA 1CHVS 4IYEA 1CCQA 3LAQU 1CDSA 4XJJA 4UY2C 2QJBC 3BT2U 1CXNA 2BTXA 1CODA 1JGKA 1QM7A 2MJ4A 1BTEA 1VB0A 1NORA 1FSSB 2ERAA 2MJ0A 1NEAA 3EVSC 1CXOA 2UWRA 2H62C 5IMYC 2N99A 1IQ9A 2CCXA 4FAOC 1IK8A 3NDSA 5DU1A 1S4YA 1G6MA 2L03A 2H8UA 1ERGA 1FSCA 1COEA 1KXIA 1HAJA 4OM4A 1ERAA 1LXGA 2MUOA 1FASA
chains in the Genus database with same CATH superfamily
2QC1A 2FD6U 4P7UA 5IMTD 2H7ZA 1F94A 1KBAA 1NTXA 4KSNA 1LX5B 1FF4A 1ONJA 4LFTA 3ERAA 1LXHA 1IJCA 3VTSA 1HC9A 3KFDI 1REWC 1NTNA 1NYUA 2H7ZB 3FEVA 1KC4A 1B41B 1CTXA 1RL5A 3HH7A 1HOYA 1MR6A 2GOOC 1HAAA 3EBXA 1QKEA 2BHIA 3PLCA 1H0JA 2CRSA 2L5SA 2MHYA 2QJ9C 3U74U 1NXBA 1MAHF 1ES7B 5DZ5A 1LSIA 2GOOB 1CVOA 2CDXA 1RGJA 1JBDA 1KL8A 1KFHA 2K3GA 2H5FA 4QTIU 4BDTB 1FRAA 2QJAC 4RUDA 1KU6B 2ABXA 2JQPA 2I9BE 3QB4B 6EBXA 2MFAA 1L4WA 1CREA 2CTXA 4HQPF 4DO8A 2CRTA 1M9ZA 2X8BB 2J8BA 2JVEA 1IDGA 4BIKB 3U73U 1W6BA 1KS6A 2H62D 1CDQA 1FFJA 3BT1U 2PJYC 1CB9A 2LCRA 1TFSA 1KBTA 1HC9B 1TXAA 1DRSA 3NH7A 5DO6A 1LJZA 1PLOA 2H64C 2UX2A 1KTZB 1XT3A 2HLQA 1IDLA 1QKDA 2HLRA 2PJYB 4OM5A 1CDRA 1TGXA 1CDTA 3KFDE 1ABTA 2H64B 1CRFA 1IDHA 1V6PA 2NBTA 4AEAA 4FAOE 1NYSA 1I02A 1TXBA 5EBXA 3NEQA 1ZADA 2LA1A 1KBSA 2MUPA 1IKCA 1F8UB 1UG4A 1IDIA 4ZQYA 2MJYA 2OFSA 4EY8B 1JE9A 2VLWA 1YWHA 1BXPA 1CHVS 4IYEA 1CCQA 3LAQU 1CDSA 4XJJA 4UY2C 2QJBC 3BT2U 1CXNA 2BTXA 1CODA 1JGKA 1QM7A 2MJ4A 1BTEA 1VB0A 1NORA 1FSSB 2ERAA 2MJ0A 1NEAA 3EVSC 1CXOA 2UWRA 2H62C 5IMYC 2N99A 1IQ9A 2CCXA 4FAOC 1IK8A 3NDSA 5DU1A 1S4YA 1G6MA 2L03A 2H8UA 1ERGA 1FSCA 1COEA 1KXIA 1HAJA 4OM4A 1ERAA 1LXGA 2MUOA 1FASA
chains in the Genus database with same CATH topology
2QC1A 2FD6U 4P7UA 5IMTD 2H7ZA 1F94A 1KBAA 1NTXA 4KSNA 1LX5B 1FF4A 1ONJA 4LFTA 3ERAA 1LXHA 1IJCA 3VTSA 1HC9A 3KFDI 1REWC 1NTNA 1NYUA 2H7ZB 3FEVA 1KC4A 1B41B 1CTXA 1RL5A 3HH7A 1HOYA 1MR6A 2GOOC 1HAAA 3EBXA 1QKEA 2BHIA 3PLCA 1H0JA 2CRSA 2L5SA 2MHYA 2QJ9C 3U74U 1NXBA 1MAHF 1ES7B 5DZ5A 1LSIA 2GOOB 1CVOA 2CDXA 1RGJA 1JBDA 1KL8A 1KFHA 2K3GA 2H5FA 4QTIU 4BDTB 1FRAA 2QJAC 4RUDA 1KU6B 2ABXA 2JQPA 2I9BE 3QB4B 6EBXA 2MFAA 1L4WA 1CREA 2CTXA 4HQPF 4DO8A 2CRTA 1M9ZA 2X8BB 2J8BA 2JVEA 1IDGA 4BIKB 3U73U 1W6BA 1KS6A 2H62D 1CDQA 1FFJA 3BT1U 2PJYC 1CB9A 2LCRA 1TFSA 1KBTA 1HC9B 1TXAA 1DRSA 3NH7A 5DO6A 1LJZA 1PLOA 2H64C 2UX2A 1KTZB 1XT3A 2HLQA 1IDLA 1QKDA 2HLRA 2PJYB 4OM5A 1CDRA 1TGXA 1CDTA 3KFDE 1ABTA 2H64B 1CRFA 1IDHA 1V6PA 2NBTA 4AEAA 4FAOE 1NYSA 1I02A 1TXBA 5EBXA 3NEQA 1ZADA 2LA1A 1KBSA 2MUPA 1IKCA 1F8UB 1UG4A 1IDIA 4ZQYA 2MJYA 2OFSA 4EY8B 1JE9A 2VLWA 1YWHA 1BXPA 1CHVS 4IYEA 1CCQA 3LAQU 1CDSA 4XJJA 4UY2C 2QJBC 3BT2U 1CXNA 2BTXA 1CODA 1JGKA 1QM7A 2MJ4A 1BTEA 1VB0A 1NORA 1FSSB 2ERAA 2MJ0A 1NEAA 3EVSC 1CXOA 2UWRA 2H62C 5IMYC 2N99A 1IQ9A 2CCXA 4FAOC 1IK8A 3NDSA 5DU1A 1S4YA 1G6MA 2L03A 2H8UA 1ERGA 1FSCA 1COEA 1KXIA 1HAJA 4OM4A 1ERAA 1LXGA 2MUOA 1FASA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QC1 A;  2FD6 U;  4P7U A;  5IMT D;  2H7Z A;  1F94 A;  1KBA A;  1NTX A;  1LX5 B;  1FF4 A;  1ONJ A;  4LFT A;  3ERA A;  1LXH A;  1IJC A;  3VTS A;  1HC9 A;  3KFD I;  1REW C;  1NTN A;  1NYU A;  2H7Z B;  3FEV A;  1KC4 A;  1B41 B;  1CTX A;  1RL5 A;  3HH7 A;  1HOY A;  1MR6 A;  2GOO C;  1HAA A;  3EBX A;  1QKE A;  2BHI A;  3PLC A;  1H0J A;  2CRS A;  2L5S A;  2MHY A;  2QJ9 C;  3U74 U;  1NXB A;  1MAH F;  1ES7 B;  5DZ5 A;  1LSI A;  2GOO B;  1CVO A;  2CDX A;  1RGJ A;  1JBD A;  1KL8 A;  1KFH A;  2K3G A;  2H5F A;  4QTI U;  4BDT B;  1FRA A;  2QJA C;  4RUD A;  1KU6 B;  2ABX A;  2JQP A;  2I9B E;  3QB4 B;  6EBX A;  2MFA A;  1L4W A;  1CRE A;  2CTX A;  4HQP F;  4DO8 A;  2CRT A;  1M9Z A;  2X8B B;  2J8B A;  2JVE A;  1IDG A;  4BIK B;  3U73 U;  1W6B A;  1KS6 A;  2H62 D;  1CDQ A;  1FFJ A;  3BT1 U;  2PJY C;  1CB9 A;  2LCR A;  1TFS A;  1KBT A;  1HC9 B;  1TXA A;  1DRS A;  3NH7 A;  5DO6 A;  1LJZ A;  1PLO A;  2H64 C;  2UX2 A;  1KTZ B;  1XT3 A;  2HLQ A;  1IDL A;  1QKD A;  2HLR A;  2PJY B;  4OM5 A;  1CDR A;  1TGX A;  1CDT A;  3KFD E;  1ABT A;  2H64 B;  1CRF A;  1IDH A;  1V6P A;  2NBT A;  4AEA A;  4FAO E;  1NYS A;  1I02 A;  1TXB A;  5EBX A;  3NEQ A;  1ZAD A;  2LA1 A;  1KBS A;  2MUP A;  1IKC A;  1F8U B;  1UG4 A;  1IDI A;  4ZQY A;  2MJY A;  2OFS A;  4EY8 B;  1JE9 A;  2VLW A;  1YWH A;  1BXP A;  1CHV S;  4IYE A;  1CCQ A;  3LAQ U;  1CDS A;  4XJJ A;  4UY2 C;  2QJB C;  3BT2 U;  1CXN A;  2BTX A;  1COD A;  1JGK A;  1QM7 A;  2MJ4 A;  1BTE A;  1VB0 A;  1NOR A;  1FSS B;  2ERA A;  2MJ0 A;  1NEA A;  3EVS C;  1CXO A;  2UWR A;  2H62 C;  5IMY C;  2N99 A;  1IQ9 A;  2CCX A;  4FAO C;  1IK8 A;  3NDS A;  5DU1 A;  1S4Y A;  1G6M A;  2L03 A;  2H8U A;  1ERG A;  1FSC A;  1COE A;  1KXI A;  1HAJ A;  4OM4 A;  1ERA A;  1LXG A;  2MUO A;  1FAS A; 
#chains in the Genus database with same CATH topology
 2QC1 A;  2FD6 U;  4P7U A;  5IMT D;  2H7Z A;  1F94 A;  1KBA A;  1NTX A;  4KSN A;  1LX5 B;  1FF4 A;  1ONJ A;  4LFT A;  3ERA A;  1LXH A;  1IJC A;  3VTS A;  1HC9 A;  3KFD I;  1REW C;  1NTN A;  1NYU A;  2H7Z B;  3FEV A;  1KC4 A;  1B41 B;  1CTX A;  1RL5 A;  3HH7 A;  1HOY A;  1MR6 A;  2GOO C;  1HAA A;  3EBX A;  1QKE A;  2BHI A;  3PLC A;  1H0J A;  2CRS A;  2L5S A;  2MHY A;  2QJ9 C;  3U74 U;  1NXB A;  1MAH F;  1ES7 B;  5DZ5 A;  1LSI A;  2GOO B;  1CVO A;  2CDX A;  1RGJ A;  1JBD A;  1KL8 A;  1KFH A;  2K3G A;  2H5F A;  4QTI U;  4BDT B;  1FRA A;  2QJA C;  4RUD A;  1KU6 B;  2ABX A;  2JQP A;  2I9B E;  3QB4 B;  6EBX A;  2MFA A;  1L4W A;  1CRE A;  2CTX A;  4HQP F;  4DO8 A;  2CRT A;  1M9Z A;  2X8B B;  2J8B A;  2JVE A;  1IDG A;  4BIK B;  3U73 U;  1W6B A;  1KS6 A;  2H62 D;  1CDQ A;  1FFJ A;  3BT1 U;  2PJY C;  1CB9 A;  2LCR A;  1TFS A;  1KBT A;  1HC9 B;  1TXA A;  1DRS A;  3NH7 A;  5DO6 A;  1LJZ A;  1PLO A;  2H64 C;  2UX2 A;  1KTZ B;  1XT3 A;  2HLQ A;  1IDL A;  1QKD A;  2HLR A;  2PJY B;  4OM5 A;  1CDR A;  1TGX A;  1CDT A;  3KFD E;  1ABT A;  2H64 B;  1CRF A;  1IDH A;  1V6P A;  2NBT A;  4AEA A;  4FAO E;  1NYS A;  1I02 A;  1TXB A;  5EBX A;  3NEQ A;  1ZAD A;  2LA1 A;  1KBS A;  2MUP A;  1IKC A;  1F8U B;  1UG4 A;  1IDI A;  4ZQY A;  2MJY A;  2OFS A;  4EY8 B;  1JE9 A;  2VLW A;  1YWH A;  1BXP A;  1CHV S;  4IYE A;  1CCQ A;  3LAQ U;  1CDS A;  4XJJ A;  4UY2 C;  2QJB C;  3BT2 U;  1CXN A;  2BTX A;  1COD A;  1JGK A;  1QM7 A;  2MJ4 A;  1BTE A;  1VB0 A;  1NOR A;  1FSS B;  2ERA A;  2MJ0 A;  1NEA A;  3EVS C;  1CXO A;  2UWR A;  2H62 C;  5IMY C;  2N99 A;  1IQ9 A;  2CCX A;  4FAO C;  1IK8 A;  3NDS A;  5DU1 A;  1S4Y A;  1G6M A;  2L03 A;  2H8U A;  1ERG A;  1FSC A;  1COE A;  1KXI A;  1HAJ A;  4OM4 A;  1ERA A;  1LXG A;  2MUO A;  1FAS A; 
#chains in the Genus database with same CATH homology
 2QC1 A;  2FD6 U;  4P7U A;  5IMT D;  2H7Z A;  1F94 A;  1KBA A;  1NTX A;  4KSN A;  1LX5 B;  1FF4 A;  1ONJ A;  4LFT A;  3ERA A;  1LXH A;  1IJC A;  3VTS A;  1HC9 A;  3KFD I;  1REW C;  1NTN A;  1NYU A;  2H7Z B;  3FEV A;  1KC4 A;  1B41 B;  1CTX A;  1RL5 A;  3HH7 A;  1HOY A;  1MR6 A;  2GOO C;  1HAA A;  3EBX A;  1QKE A;  2BHI A;  3PLC A;  1H0J A;  2CRS A;  2L5S A;  2MHY A;  2QJ9 C;  3U74 U;  1NXB A;  1MAH F;  1ES7 B;  5DZ5 A;  1LSI A;  2GOO B;  1CVO A;  2CDX A;  1RGJ A;  1JBD A;  1KL8 A;  1KFH A;  2K3G A;  2H5F A;  4QTI U;  4BDT B;  1FRA A;  2QJA C;  4RUD A;  1KU6 B;  2ABX A;  2JQP A;  2I9B E;  3QB4 B;  6EBX A;  2MFA A;  1L4W A;  1CRE A;  2CTX A;  4HQP F;  4DO8 A;  2CRT A;  1M9Z A;  2X8B B;  2J8B A;  2JVE A;  1IDG A;  4BIK B;  3U73 U;  1W6B A;  1KS6 A;  2H62 D;  1CDQ A;  1FFJ A;  3BT1 U;  2PJY C;  1CB9 A;  2LCR A;  1TFS A;  1KBT A;  1HC9 B;  1TXA A;  1DRS A;  3NH7 A;  5DO6 A;  1LJZ A;  1PLO A;  2H64 C;  2UX2 A;  1KTZ B;  1XT3 A;  2HLQ A;  1IDL A;  1QKD A;  2HLR A;  2PJY B;  4OM5 A;  1CDR A;  1TGX A;  1CDT A;  3KFD E;  1ABT A;  2H64 B;  1CRF A;  1IDH A;  1V6P A;  2NBT A;  4AEA A;  4FAO E;  1NYS A;  1I02 A;  1TXB A;  5EBX A;  3NEQ A;  1ZAD A;  2LA1 A;  1KBS A;  2MUP A;  1IKC A;  1F8U B;  1UG4 A;  1IDI A;  4ZQY A;  2MJY A;  2OFS A;  4EY8 B;  1JE9 A;  2VLW A;  1YWH A;  1BXP A;  1CHV S;  4IYE A;  1CCQ A;  3LAQ U;  1CDS A;  4XJJ A;  4UY2 C;  2QJB C;  3BT2 U;  1CXN A;  2BTX A;  1COD A;  1JGK A;  1QM7 A;  2MJ4 A;  1BTE A;  1VB0 A;  1NOR A;  1FSS B;  2ERA A;  2MJ0 A;  1NEA A;  3EVS C;  1CXO A;  2UWR A;  2H62 C;  5IMY C;  2N99 A;  1IQ9 A;  2CCX A;  4FAO C;  1IK8 A;  3NDS A;  5DU1 A;  1S4Y A;  1G6M A;  2L03 A;  2H8U A;  1ERG A;  1FSC A;  1COE A;  1KXI A;  1HAJ A;  4OM4 A;  1ERA A;  1LXG A;  2MUO A;  1FAS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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