4FAOE

Specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
91
structure length
91
Chain Sequence
RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein/signaling protein
source organism Homo sapiens
publication title Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex.
pubmed doi rcsb
molecule keywords Growth/differentiation factor 2
total genus 19
structure length 91
sequence length 91
chains with identical sequence F, K, L, Q, R, W, X, e, f, k, l
ec nomenclature ec 2.7.11.30: Receptor protein serine/threonine kinase.
pdb deposition date 2012-05-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4faoE00
2OFSA 2H64C 1FFJA 2MHYA 1KBTA 1RL5A 1KXIA 3KFDE 1LJZA 4FAOE 1HC9B 1IDLA 1CVOA 1ERAA 1KTZB 2H64B 1RGJA 2UWRA 1S4YA 2N99A 2X8BB 1NEAA 5DU1A 3NH7A 2LA1A 1B41B 6EBXA 1JBDA 4AEAA 2K3GA 3ERAA 2H62C 2BHIA 1H0JA 1QKEA 1IKCA 1JE9A 1KU6B 1CODA 1V6PA 2PJYB 1KBSA 2CDXA 1REWC 2H62D 4UY2C 1G6MA 2ABXA 2UX2A 2CRTA 2J8BA 1CXOA 1TFSA 1QM7A 2H7ZA 2NBTA 2VLWA 1FRAA 1TXAA 1CDSA 2BTXA 3PLCA 1CREA 1CXNA 1CDQA 2H8UA 2L5SA 2QC1A 4BDTB 1IK8A 2MJ4A 3KFDI 1CHVS 2LCRA 2HLRA 2MJYA 1IQ9A 3EBXA 1MAHF 2JQPA 1NXBA 1DRSA 2MJ0A 1COEA 2H5FA 2HLQA 1KS6A 1HC9A 4DO8A 1W6BA 2QJ9C 3QB4B 1JGKA 1IDGA 1CDRA 3BT1U 1CB9A 4EY8B 3FEVA 4OM5A 5IMTD 3NEQA 1XT3A 1MR6A 2GOOC 4BIKB 3BT2U 3LAQU 4OM4A 3U74U 2CCXA 2L03A 1LSIA 1LXHA 1TXBA 2MUOA 1KFHA 1KL8A 1LX5B 1FASA 1NORA 2GOOB 3NDSA 1BTEA 1ONJA 4ZQYA 1ERGA 4P7UA 1NYUA 2CRSA 2MFAA 1IDHA 1VB0A 1FSCA 1TGXA 2ERAA 3EVSC 5DZ5A 1FF4A 1HAAA 2JVEA 2FD6U 4IYEA 1F94A 1ZADA 5DO6A 1CDTA 2QJAC 5IMYC 4QTIU 1UG4A 1NYSA 4LFTA 1FSSB 1BXPA 1KC4A 1ES7B 1HAJA 1NTNA 2CTXA 3U73U 1CTXA 1NTXA 1HOYA 1YWHA 1M9ZA 1F8UB 2QJBC 5EBXA 2MUPA 1CRFA 2PJYC 2H7ZB 1IJCA 1CCQA 3HH7A 4FAOC 1I02A 1KBAA 1PLOA 4HQPF 2I9BE 1L4WA 1QKDA 4XJJA 4RUDA 1IDIA 1ABTA 3VTSA 1LXGA
chains in the Genus database with same CATH superfamily
2OFSA 2H64C 1FFJA 2MHYA 1KBTA 1RL5A 1KXIA 3KFDE 1LJZA 4FAOE 1HC9B 1IDLA 1CVOA 1ERAA 1KTZB 2H64B 1RGJA 2UWRA 1S4YA 2N99A 2X8BB 1NEAA 5DU1A 3NH7A 2LA1A 1B41B 6EBXA 1JBDA 4AEAA 2K3GA 3ERAA 2H62C 2BHIA 1H0JA 1QKEA 1IKCA 1JE9A 1KU6B 1CODA 1V6PA 2PJYB 1KBSA 2CDXA 1REWC 2H62D 4UY2C 1G6MA 2ABXA 2UX2A 2CRTA 2J8BA 1CXOA 1TFSA 1QM7A 2H7ZA 2NBTA 4KSNA 2VLWA 1FRAA 1TXAA 1CDSA 2BTXA 3PLCA 1CREA 1CXNA 1CDQA 2H8UA 2L5SA 2QC1A 4BDTB 1IK8A 2MJ4A 3KFDI 1CHVS 2LCRA 2HLRA 2MJYA 1IQ9A 3EBXA 1MAHF 2JQPA 1NXBA 1DRSA 2MJ0A 1COEA 2H5FA 2HLQA 1KS6A 1HC9A 4DO8A 1W6BA 2QJ9C 3QB4B 1JGKA 1IDGA 1CDRA 3BT1U 1CB9A 4EY8B 3FEVA 4OM5A 5IMTD 3NEQA 1XT3A 1MR6A 2GOOC 4BIKB 3BT2U 3LAQU 4OM4A 3U74U 2CCXA 2L03A 1LSIA 1LXHA 1TXBA 2MUOA 1KFHA 1KL8A 1LX5B 1FASA 1NORA 2GOOB 3NDSA 1BTEA 1ONJA 4ZQYA 1ERGA 4P7UA 1NYUA 2CRSA 2MFAA 1IDHA 1VB0A 1FSCA 1TGXA 2ERAA 3EVSC 5DZ5A 1FF4A 1HAAA 2JVEA 2FD6U 4IYEA 1F94A 1ZADA 5DO6A 1CDTA 2QJAC 5IMYC 4QTIU 1UG4A 1NYSA 4LFTA 1FSSB 1BXPA 1KC4A 1ES7B 1HAJA 1NTNA 2CTXA 3U73U 1CTXA 1NTXA 1HOYA 1YWHA 1M9ZA 1F8UB 2QJBC 5EBXA 2MUPA 1CRFA 2PJYC 2H7ZB 1IJCA 1CCQA 3HH7A 4FAOC 1I02A 1KBAA 1PLOA 4HQPF 2I9BE 1L4WA 1QKDA 4XJJA 4RUDA 1IDIA 1ABTA 3VTSA 1LXGA
chains in the Genus database with same CATH topology
2OFSA 2H64C 1FFJA 2MHYA 1KBTA 1RL5A 1KXIA 3KFDE 1LJZA 4FAOE 1HC9B 1IDLA 1CVOA 1ERAA 1KTZB 2H64B 1RGJA 2UWRA 1S4YA 2N99A 2X8BB 1NEAA 5DU1A 3NH7A 2LA1A 1B41B 6EBXA 1JBDA 4AEAA 2K3GA 3ERAA 2H62C 2BHIA 1H0JA 1QKEA 1IKCA 1JE9A 1KU6B 1CODA 1V6PA 2PJYB 1KBSA 2CDXA 1REWC 2H62D 4UY2C 1G6MA 2ABXA 2UX2A 2CRTA 2J8BA 1CXOA 1TFSA 1QM7A 2H7ZA 2NBTA 4KSNA 2VLWA 1FRAA 1TXAA 1CDSA 2BTXA 3PLCA 1CREA 1CXNA 1CDQA 2H8UA 2L5SA 2QC1A 4BDTB 1IK8A 2MJ4A 3KFDI 1CHVS 2LCRA 2HLRA 2MJYA 1IQ9A 3EBXA 1MAHF 2JQPA 1NXBA 1DRSA 2MJ0A 1COEA 2H5FA 2HLQA 1KS6A 1HC9A 4DO8A 1W6BA 2QJ9C 3QB4B 1JGKA 1IDGA 1CDRA 3BT1U 1CB9A 4EY8B 3FEVA 4OM5A 5IMTD 3NEQA 1XT3A 1MR6A 2GOOC 4BIKB 3BT2U 3LAQU 4OM4A 3U74U 2CCXA 2L03A 1LSIA 1LXHA 1TXBA 2MUOA 1KFHA 1KL8A 1LX5B 1FASA 1NORA 2GOOB 3NDSA 1BTEA 1ONJA 4ZQYA 1ERGA 4P7UA 1NYUA 2CRSA 2MFAA 1IDHA 1VB0A 1FSCA 1TGXA 2ERAA 3EVSC 5DZ5A 1FF4A 1HAAA 2JVEA 2FD6U 4IYEA 1F94A 1ZADA 5DO6A 1CDTA 2QJAC 5IMYC 4QTIU 1UG4A 1NYSA 4LFTA 1FSSB 1BXPA 1KC4A 1ES7B 1HAJA 1NTNA 2CTXA 3U73U 1CTXA 1NTXA 1HOYA 1YWHA 1M9ZA 1F8UB 2QJBC 5EBXA 2MUPA 1CRFA 2PJYC 2H7ZB 1IJCA 1CCQA 3HH7A 4FAOC 1I02A 1KBAA 1PLOA 4HQPF 2I9BE 1L4WA 1QKDA 4XJJA 4RUDA 1IDIA 1ABTA 3VTSA 1LXGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OFS A;  2H64 C;  1FFJ A;  2MHY A;  1KBT A;  1RL5 A;  1KXI A;  3KFD E;  1LJZ A;  4FAO E;  1HC9 B;  1IDL A;  1CVO A;  1ERA A;  1KTZ B;  2H64 B;  1RGJ A;  2UWR A;  1S4Y A;  2N99 A;  2X8B B;  1NEA A;  5DU1 A;  3NH7 A;  2LA1 A;  1B41 B;  6EBX A;  1JBD A;  4AEA A;  2K3G A;  3ERA A;  2H62 C;  2BHI A;  1H0J A;  1QKE A;  1IKC A;  1JE9 A;  1KU6 B;  1COD A;  1V6P A;  2PJY B;  1KBS A;  2CDX A;  1REW C;  2H62 D;  4UY2 C;  1G6M A;  2ABX A;  2UX2 A;  2CRT A;  2J8B A;  1CXO A;  1TFS A;  1QM7 A;  2H7Z A;  2NBT A;  2VLW A;  1FRA A;  1TXA A;  1CDS A;  2BTX A;  3PLC A;  1CRE A;  1CXN A;  1CDQ A;  2H8U A;  2L5S A;  2QC1 A;  4BDT B;  1IK8 A;  2MJ4 A;  3KFD I;  1CHV S;  2LCR A;  2HLR A;  2MJY A;  1IQ9 A;  3EBX A;  1MAH F;  2JQP A;  1NXB A;  1DRS A;  2MJ0 A;  1COE A;  2H5F A;  2HLQ A;  1KS6 A;  1HC9 A;  4DO8 A;  1W6B A;  2QJ9 C;  3QB4 B;  1JGK A;  1IDG A;  1CDR A;  3BT1 U;  1CB9 A;  4EY8 B;  3FEV A;  4OM5 A;  5IMT D;  3NEQ A;  1XT3 A;  1MR6 A;  2GOO C;  4BIK B;  3BT2 U;  3LAQ U;  4OM4 A;  3U74 U;  2CCX A;  2L03 A;  1LSI A;  1LXH A;  1TXB A;  2MUO A;  1KFH A;  1KL8 A;  1LX5 B;  1FAS A;  1NOR A;  2GOO B;  3NDS A;  1BTE A;  1ONJ A;  4ZQY A;  1ERG A;  4P7U A;  1NYU A;  2CRS A;  2MFA A;  1IDH A;  1VB0 A;  1FSC A;  1TGX A;  2ERA A;  3EVS C;  5DZ5 A;  1FF4 A;  1HAA A;  2JVE A;  2FD6 U;  4IYE A;  1F94 A;  1ZAD A;  5DO6 A;  1CDT A;  2QJA C;  5IMY C;  4QTI U;  1UG4 A;  1NYS A;  4LFT A;  1FSS B;  1BXP A;  1KC4 A;  1ES7 B;  1HAJ A;  1NTN A;  2CTX A;  3U73 U;  1CTX A;  1NTX A;  1HOY A;  1YWH A;  1M9Z A;  1F8U B;  2QJB C;  5EBX A;  2MUP A;  1CRF A;  2PJY C;  2H7Z B;  1IJC A;  1CCQ A;  3HH7 A;  4FAO C;  1I02 A;  1KBA A;  1PLO A;  4HQP F;  2I9B E;  1L4W A;  1QKD A;  4XJJ A;  4RUD A;  1IDI A;  1ABT A;  3VTS A;  1LXG A; 
#chains in the Genus database with same CATH topology
 2OFS A;  2H64 C;  1FFJ A;  2MHY A;  1KBT A;  1RL5 A;  1KXI A;  3KFD E;  1LJZ A;  4FAO E;  1HC9 B;  1IDL A;  1CVO A;  1ERA A;  1KTZ B;  2H64 B;  1RGJ A;  2UWR A;  1S4Y A;  2N99 A;  2X8B B;  1NEA A;  5DU1 A;  3NH7 A;  2LA1 A;  1B41 B;  6EBX A;  1JBD A;  4AEA A;  2K3G A;  3ERA A;  2H62 C;  2BHI A;  1H0J A;  1QKE A;  1IKC A;  1JE9 A;  1KU6 B;  1COD A;  1V6P A;  2PJY B;  1KBS A;  2CDX A;  1REW C;  2H62 D;  4UY2 C;  1G6M A;  2ABX A;  2UX2 A;  2CRT A;  2J8B A;  1CXO A;  1TFS A;  1QM7 A;  2H7Z A;  2NBT A;  4KSN A;  2VLW A;  1FRA A;  1TXA A;  1CDS A;  2BTX A;  3PLC A;  1CRE A;  1CXN A;  1CDQ A;  2H8U A;  2L5S A;  2QC1 A;  4BDT B;  1IK8 A;  2MJ4 A;  3KFD I;  1CHV S;  2LCR A;  2HLR A;  2MJY A;  1IQ9 A;  3EBX A;  1MAH F;  2JQP A;  1NXB A;  1DRS A;  2MJ0 A;  1COE A;  2H5F A;  2HLQ A;  1KS6 A;  1HC9 A;  4DO8 A;  1W6B A;  2QJ9 C;  3QB4 B;  1JGK A;  1IDG A;  1CDR A;  3BT1 U;  1CB9 A;  4EY8 B;  3FEV A;  4OM5 A;  5IMT D;  3NEQ A;  1XT3 A;  1MR6 A;  2GOO C;  4BIK B;  3BT2 U;  3LAQ U;  4OM4 A;  3U74 U;  2CCX A;  2L03 A;  1LSI A;  1LXH A;  1TXB A;  2MUO A;  1KFH A;  1KL8 A;  1LX5 B;  1FAS A;  1NOR A;  2GOO B;  3NDS A;  1BTE A;  1ONJ A;  4ZQY A;  1ERG A;  4P7U A;  1NYU A;  2CRS A;  2MFA A;  1IDH A;  1VB0 A;  1FSC A;  1TGX A;  2ERA A;  3EVS C;  5DZ5 A;  1FF4 A;  1HAA A;  2JVE A;  2FD6 U;  4IYE A;  1F94 A;  1ZAD A;  5DO6 A;  1CDT A;  2QJA C;  5IMY C;  4QTI U;  1UG4 A;  1NYS A;  4LFT A;  1FSS B;  1BXP A;  1KC4 A;  1ES7 B;  1HAJ A;  1NTN A;  2CTX A;  3U73 U;  1CTX A;  1NTX A;  1HOY A;  1YWH A;  1M9Z A;  1F8U B;  2QJB C;  5EBX A;  2MUP A;  1CRF A;  2PJY C;  2H7Z B;  1IJC A;  1CCQ A;  3HH7 A;  4FAO C;  1I02 A;  1KBA A;  1PLO A;  4HQP F;  2I9B E;  1L4W A;  1QKD A;  4XJJ A;  4RUD A;  1IDI A;  1ABT A;  3VTS A;  1LXG A; 
#chains in the Genus database with same CATH homology
 2OFS A;  2H64 C;  1FFJ A;  2MHY A;  1KBT A;  1RL5 A;  1KXI A;  3KFD E;  1LJZ A;  4FAO E;  1HC9 B;  1IDL A;  1CVO A;  1ERA A;  1KTZ B;  2H64 B;  1RGJ A;  2UWR A;  1S4Y A;  2N99 A;  2X8B B;  1NEA A;  5DU1 A;  3NH7 A;  2LA1 A;  1B41 B;  6EBX A;  1JBD A;  4AEA A;  2K3G A;  3ERA A;  2H62 C;  2BHI A;  1H0J A;  1QKE A;  1IKC A;  1JE9 A;  1KU6 B;  1COD A;  1V6P A;  2PJY B;  1KBS A;  2CDX A;  1REW C;  2H62 D;  4UY2 C;  1G6M A;  2ABX A;  2UX2 A;  2CRT A;  2J8B A;  1CXO A;  1TFS A;  1QM7 A;  2H7Z A;  2NBT A;  4KSN A;  2VLW A;  1FRA A;  1TXA A;  1CDS A;  2BTX A;  3PLC A;  1CRE A;  1CXN A;  1CDQ A;  2H8U A;  2L5S A;  2QC1 A;  4BDT B;  1IK8 A;  2MJ4 A;  3KFD I;  1CHV S;  2LCR A;  2HLR A;  2MJY A;  1IQ9 A;  3EBX A;  1MAH F;  2JQP A;  1NXB A;  1DRS A;  2MJ0 A;  1COE A;  2H5F A;  2HLQ A;  1KS6 A;  1HC9 A;  4DO8 A;  1W6B A;  2QJ9 C;  3QB4 B;  1JGK A;  1IDG A;  1CDR A;  3BT1 U;  1CB9 A;  4EY8 B;  3FEV A;  4OM5 A;  5IMT D;  3NEQ A;  1XT3 A;  1MR6 A;  2GOO C;  4BIK B;  3BT2 U;  3LAQ U;  4OM4 A;  3U74 U;  2CCX A;  2L03 A;  1LSI A;  1LXH A;  1TXB A;  2MUO A;  1KFH A;  1KL8 A;  1LX5 B;  1FAS A;  1NOR A;  2GOO B;  3NDS A;  1BTE A;  1ONJ A;  4ZQY A;  1ERG A;  4P7U A;  1NYU A;  2CRS A;  2MFA A;  1IDH A;  1VB0 A;  1FSC A;  1TGX A;  2ERA A;  3EVS C;  5DZ5 A;  1FF4 A;  1HAA A;  2JVE A;  2FD6 U;  4IYE A;  1F94 A;  1ZAD A;  5DO6 A;  1CDT A;  2QJA C;  5IMY C;  4QTI U;  1UG4 A;  1NYS A;  4LFT A;  1FSS B;  1BXP A;  1KC4 A;  1ES7 B;  1HAJ A;  1NTN A;  2CTX A;  3U73 U;  1CTX A;  1NTX A;  1HOY A;  1YWH A;  1M9Z A;  1F8U B;  2QJB C;  5EBX A;  2MUP A;  1CRF A;  2PJY C;  2H7Z B;  1IJC A;  1CCQ A;  3HH7 A;  4FAO C;  1I02 A;  1KBA A;  1PLO A;  4HQP F;  2I9B E;  1L4W A;  1QKD A;  4XJJ A;  4RUD A;  1IDI A;  1ABT A;  3VTS A;  1LXG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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