4HQPF

Alpha7 nicotinic receptor chimera and its complex with alpha bungarotoxin
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
73
structure length
73
Chain Sequence
IVCHTTATSPISAVTCPPGENLCYRKMWCDVFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural principles for Alpha-neurotoxin binding to and selectivity among nicotinic receptors
rcsb
molecule tags Protein binding
source organism Homo sapiens, lymnaea stagnalis
molecule keywords Alpha7 nicotinic receptor chimera
total genus 8
structure length 73
sequence length 73
chains with identical sequence G, H, I, J
ec nomenclature
pdb deposition date 2012-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF00087 Toxin_TOLIP Snake toxin and toxin-like protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4hqpF00
5IMTD 2X8BB 1I02A 1IDLA 2K3GA 1KBTA 4FAOE 1IJCA 1KBSA 1FASA 1M9ZA 1NORA 2MUOA 1CB9A 1NEAA 1RGJA 1LJZA 2H8UA 1CRFA 1TXAA 1V6PA 4OM4A 1QKDA 1KU6B 1CXNA 1ES7B 1LXHA 2PJYB 1ERAA 1CREA 4FAOC 1CDRA 2CTXA 3QB4B 2ABXA 3EVSC 2MHYA 1FSCA 1CDQA 2QJAC 1BTEA 2CDXA 2CRSA 2MJYA 4BIKB 1TGXA 3NDSA 1REWC 3HH7A 1KFHA 2L5SA 3VTSA 1IQ9A 1ZADA 2MUPA 4UY2C 1KXIA 2JQPA 1CDSA 1MAHF 1VB0A 3U73U 1KL8A 1CTXA 1LSIA 3KFDE 2UX2A 3KFDI 1YWHA 1XT3A 1NYUA 5EBXA 3ERAA 1H0JA 2MFAA 1BXPA 1NTNA 2J8BA 1KTZB 5IMYC 1PLOA 2GOOC 1TFSA 4ZQYA 1MR6A 1DRSA 3EBXA 5DO6A 1CODA 2BTXA 2FD6U 1F94A 1HC9A 2UWRA 1HAJA 1CVOA 1IDHA 2H62D 4AEAA 1G6MA 1HOYA 4RUDA 1CDTA 1HC9B 1UG4A 2QC1A 1FF4A 2MJ0A 2ERAA 2BHIA 1S4YA 1CCQA 2H62C 2LCRA 4OM5A 4BDTB 1JGKA 1NYSA 1HAAA 2OFSA 1NTXA 4IYEA 3PLCA 4EY8B 2NBTA 1LX5B 2GOOB 1RL5A 1LXGA 1IKCA 1IDGA 5DU1A 1IK8A 1FSSB 1KS6A 3NEQA 1QKEA 2QJBC 2MJ4A 3FEVA 1JE9A 3U74U 1FFJA 1FRAA 2VLWA 1IDIA 1B41B 2QJ9C 4LFTA 1TXBA 4DO8A 3NH7A 1ERGA 6EBXA 1KBAA 1CHVS 1L4WA 1QM7A 2JVEA 2H64C 4QTIU 4XJJA 4HQPF 1COEA 2H7ZA 1W6BA 2CCXA 3BT1U 2H5FA 5DZ5A 1CXOA 2HLRA 2N99A 2LA1A 2H7ZB 1ONJA 2PJYC 1ABTA 1KC4A 3LAQU 4P7UA 2I9BE 2CRTA 1JBDA 2L03A 1NXBA 3BT2U 2HLQA 2H64B 1F8UB
chains in the Genus database with same CATH superfamily
5IMTD 2X8BB 1I02A 1IDLA 2K3GA 1KBTA 4FAOE 1IJCA 1KBSA 1FASA 1M9ZA 1NORA 2MUOA 1CB9A 1NEAA 1RGJA 1LJZA 2H8UA 1CRFA 1TXAA 1V6PA 4OM4A 1QKDA 1KU6B 1CXNA 1ES7B 1LXHA 2PJYB 1ERAA 1CREA 4FAOC 1CDRA 2CTXA 3QB4B 2ABXA 3EVSC 2MHYA 1FSCA 1CDQA 2QJAC 1BTEA 2CDXA 2CRSA 2MJYA 4BIKB 1TGXA 3NDSA 1REWC 3HH7A 1KFHA 2L5SA 3VTSA 1IQ9A 1ZADA 2MUPA 4UY2C 1KXIA 2JQPA 1CDSA 1MAHF 1VB0A 3U73U 1KL8A 1CTXA 1LSIA 3KFDE 2UX2A 3KFDI 1YWHA 1XT3A 1NYUA 5EBXA 3ERAA 1H0JA 2MFAA 1BXPA 1NTNA 2J8BA 1KTZB 5IMYC 1PLOA 2GOOC 1TFSA 4ZQYA 1MR6A 1DRSA 3EBXA 5DO6A 1CODA 2BTXA 2FD6U 1F94A 1HC9A 2UWRA 1HAJA 1CVOA 1IDHA 2H62D 4AEAA 1G6MA 1HOYA 4RUDA 1CDTA 1HC9B 1UG4A 2QC1A 1FF4A 2MJ0A 2ERAA 2BHIA 1S4YA 1CCQA 2H62C 2LCRA 4OM5A 4BDTB 1JGKA 1NYSA 1HAAA 2OFSA 1NTXA 4IYEA 3PLCA 4EY8B 2NBTA 1LX5B 2GOOB 1RL5A 1LXGA 1IKCA 1IDGA 5DU1A 1IK8A 1FSSB 1KS6A 3NEQA 1QKEA 2QJBC 2MJ4A 3FEVA 1JE9A 3U74U 1FFJA 1FRAA 4KSNA 2VLWA 1IDIA 1B41B 2QJ9C 4LFTA 1TXBA 4DO8A 3NH7A 1ERGA 6EBXA 1KBAA 1CHVS 1L4WA 1QM7A 2JVEA 2H64C 4QTIU 4XJJA 4HQPF 1COEA 2H7ZA 1W6BA 2CCXA 3BT1U 2H5FA 5DZ5A 1CXOA 2HLRA 2N99A 2LA1A 2H7ZB 1ONJA 2PJYC 1ABTA 1KC4A 3LAQU 4P7UA 2I9BE 2CRTA 1JBDA 2L03A 1NXBA 3BT2U 2HLQA 2H64B 1F8UB
chains in the Genus database with same CATH topology
5IMTD 2X8BB 1I02A 1IDLA 2K3GA 1KBTA 4FAOE 1IJCA 1KBSA 1FASA 1M9ZA 1NORA 2MUOA 1CB9A 1NEAA 1RGJA 1LJZA 2H8UA 1CRFA 1TXAA 1V6PA 4OM4A 1QKDA 1KU6B 1CXNA 1ES7B 1LXHA 2PJYB 1ERAA 1CREA 4FAOC 1CDRA 2CTXA 3QB4B 2ABXA 3EVSC 2MHYA 1FSCA 1CDQA 2QJAC 1BTEA 2CDXA 2CRSA 2MJYA 4BIKB 1TGXA 3NDSA 1REWC 3HH7A 1KFHA 2L5SA 3VTSA 1IQ9A 1ZADA 2MUPA 4UY2C 1KXIA 2JQPA 1CDSA 1MAHF 1VB0A 3U73U 1KL8A 1CTXA 1LSIA 3KFDE 2UX2A 3KFDI 1YWHA 1XT3A 1NYUA 5EBXA 3ERAA 1H0JA 2MFAA 1BXPA 1NTNA 2J8BA 1KTZB 5IMYC 1PLOA 2GOOC 1TFSA 4ZQYA 1MR6A 1DRSA 3EBXA 5DO6A 1CODA 2BTXA 2FD6U 1F94A 1HC9A 2UWRA 1HAJA 1CVOA 1IDHA 2H62D 4AEAA 1G6MA 1HOYA 4RUDA 1CDTA 1HC9B 1UG4A 2QC1A 1FF4A 2MJ0A 2ERAA 2BHIA 1S4YA 1CCQA 2H62C 2LCRA 4OM5A 4BDTB 1JGKA 1NYSA 1HAAA 2OFSA 1NTXA 4IYEA 3PLCA 4EY8B 2NBTA 1LX5B 2GOOB 1RL5A 1LXGA 1IKCA 1IDGA 5DU1A 1IK8A 1FSSB 1KS6A 3NEQA 1QKEA 2QJBC 2MJ4A 3FEVA 1JE9A 3U74U 1FFJA 1FRAA 4KSNA 2VLWA 1IDIA 1B41B 2QJ9C 4LFTA 1TXBA 4DO8A 3NH7A 1ERGA 6EBXA 1KBAA 1CHVS 1L4WA 1QM7A 2JVEA 2H64C 4QTIU 4XJJA 4HQPF 1COEA 2H7ZA 1W6BA 2CCXA 3BT1U 2H5FA 5DZ5A 1CXOA 2HLRA 2N99A 2LA1A 2H7ZB 1ONJA 2PJYC 1ABTA 1KC4A 3LAQU 4P7UA 2I9BE 2CRTA 1JBDA 2L03A 1NXBA 3BT2U 2HLQA 2H64B 1F8UB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5IMT D;  2X8B B;  1I02 A;  1IDL A;  2K3G A;  1KBT A;  4FAO E;  1IJC A;  1KBS A;  1FAS A;  1M9Z A;  1NOR A;  2MUO A;  1CB9 A;  1NEA A;  1RGJ A;  1LJZ A;  2H8U A;  1CRF A;  1TXA A;  1V6P A;  4OM4 A;  1QKD A;  1KU6 B;  1CXN A;  1ES7 B;  1LXH A;  2PJY B;  1ERA A;  1CRE A;  4FAO C;  1CDR A;  2CTX A;  3QB4 B;  2ABX A;  3EVS C;  2MHY A;  1FSC A;  1CDQ A;  2QJA C;  1BTE A;  2CDX A;  2CRS A;  2MJY A;  4BIK B;  1TGX A;  3NDS A;  1REW C;  3HH7 A;  1KFH A;  2L5S A;  3VTS A;  1IQ9 A;  1ZAD A;  2MUP A;  4UY2 C;  1KXI A;  2JQP A;  1CDS A;  1MAH F;  1VB0 A;  3U73 U;  1KL8 A;  1CTX A;  1LSI A;  3KFD E;  2UX2 A;  3KFD I;  1YWH A;  1XT3 A;  1NYU A;  5EBX A;  3ERA A;  1H0J A;  2MFA A;  1BXP A;  1NTN A;  2J8B A;  1KTZ B;  5IMY C;  1PLO A;  2GOO C;  1TFS A;  4ZQY A;  1MR6 A;  1DRS A;  3EBX A;  5DO6 A;  1COD A;  2BTX A;  2FD6 U;  1F94 A;  1HC9 A;  2UWR A;  1HAJ A;  1CVO A;  1IDH A;  2H62 D;  4AEA A;  1G6M A;  1HOY A;  4RUD A;  1CDT A;  1HC9 B;  1UG4 A;  2QC1 A;  1FF4 A;  2MJ0 A;  2ERA A;  2BHI A;  1S4Y A;  1CCQ A;  2H62 C;  2LCR A;  4OM5 A;  4BDT B;  1JGK A;  1NYS A;  1HAA A;  2OFS A;  1NTX A;  4IYE A;  3PLC A;  4EY8 B;  2NBT A;  1LX5 B;  2GOO B;  1RL5 A;  1LXG A;  1IKC A;  1IDG A;  5DU1 A;  1IK8 A;  1FSS B;  1KS6 A;  3NEQ A;  1QKE A;  2QJB C;  2MJ4 A;  3FEV A;  1JE9 A;  3U74 U;  1FFJ A;  1FRA A;  2VLW A;  1IDI A;  1B41 B;  2QJ9 C;  4LFT A;  1TXB A;  4DO8 A;  3NH7 A;  1ERG A;  6EBX A;  1KBA A;  1CHV S;  1L4W A;  1QM7 A;  2JVE A;  2H64 C;  4QTI U;  4XJJ A;  4HQP F;  1COE A;  2H7Z A;  1W6B A;  2CCX A;  3BT1 U;  2H5F A;  5DZ5 A;  1CXO A;  2HLR A;  2N99 A;  2LA1 A;  2H7Z B;  1ONJ A;  2PJY C;  1ABT A;  1KC4 A;  3LAQ U;  4P7U A;  2I9B E;  2CRT A;  1JBD A;  2L03 A;  1NXB A;  3BT2 U;  2HLQ A;  2H64 B;  1F8U B; 
#chains in the Genus database with same CATH topology
 5IMT D;  2X8B B;  1I02 A;  1IDL A;  2K3G A;  1KBT A;  4FAO E;  1IJC A;  1KBS A;  1FAS A;  1M9Z A;  1NOR A;  2MUO A;  1CB9 A;  1NEA A;  1RGJ A;  1LJZ A;  2H8U A;  1CRF A;  1TXA A;  1V6P A;  4OM4 A;  1QKD A;  1KU6 B;  1CXN A;  1ES7 B;  1LXH A;  2PJY B;  1ERA A;  1CRE A;  4FAO C;  1CDR A;  2CTX A;  3QB4 B;  2ABX A;  3EVS C;  2MHY A;  1FSC A;  1CDQ A;  2QJA C;  1BTE A;  2CDX A;  2CRS A;  2MJY A;  4BIK B;  1TGX A;  3NDS A;  1REW C;  3HH7 A;  1KFH A;  2L5S A;  3VTS A;  1IQ9 A;  1ZAD A;  2MUP A;  4UY2 C;  1KXI A;  2JQP A;  1CDS A;  1MAH F;  1VB0 A;  3U73 U;  1KL8 A;  1CTX A;  1LSI A;  3KFD E;  2UX2 A;  3KFD I;  1YWH A;  1XT3 A;  1NYU A;  5EBX A;  3ERA A;  1H0J A;  2MFA A;  1BXP A;  1NTN A;  2J8B A;  1KTZ B;  5IMY C;  1PLO A;  2GOO C;  1TFS A;  4ZQY A;  1MR6 A;  1DRS A;  3EBX A;  5DO6 A;  1COD A;  2BTX A;  2FD6 U;  1F94 A;  1HC9 A;  2UWR A;  1HAJ A;  1CVO A;  1IDH A;  2H62 D;  4AEA A;  1G6M A;  1HOY A;  4RUD A;  1CDT A;  1HC9 B;  1UG4 A;  2QC1 A;  1FF4 A;  2MJ0 A;  2ERA A;  2BHI A;  1S4Y A;  1CCQ A;  2H62 C;  2LCR A;  4OM5 A;  4BDT B;  1JGK A;  1NYS A;  1HAA A;  2OFS A;  1NTX A;  4IYE A;  3PLC A;  4EY8 B;  2NBT A;  1LX5 B;  2GOO B;  1RL5 A;  1LXG A;  1IKC A;  1IDG A;  5DU1 A;  1IK8 A;  1FSS B;  1KS6 A;  3NEQ A;  1QKE A;  2QJB C;  2MJ4 A;  3FEV A;  1JE9 A;  3U74 U;  1FFJ A;  1FRA A;  4KSN A;  2VLW A;  1IDI A;  1B41 B;  2QJ9 C;  4LFT A;  1TXB A;  4DO8 A;  3NH7 A;  1ERG A;  6EBX A;  1KBA A;  1CHV S;  1L4W A;  1QM7 A;  2JVE A;  2H64 C;  4QTI U;  4XJJ A;  4HQP F;  1COE A;  2H7Z A;  1W6B A;  2CCX A;  3BT1 U;  2H5F A;  5DZ5 A;  1CXO A;  2HLR A;  2N99 A;  2LA1 A;  2H7Z B;  1ONJ A;  2PJY C;  1ABT A;  1KC4 A;  3LAQ U;  4P7U A;  2I9B E;  2CRT A;  1JBD A;  2L03 A;  1NXB A;  3BT2 U;  2HLQ A;  2H64 B;  1F8U B; 
#chains in the Genus database with same CATH homology
 5IMT D;  2X8B B;  1I02 A;  1IDL A;  2K3G A;  1KBT A;  4FAO E;  1IJC A;  1KBS A;  1FAS A;  1M9Z A;  1NOR A;  2MUO A;  1CB9 A;  1NEA A;  1RGJ A;  1LJZ A;  2H8U A;  1CRF A;  1TXA A;  1V6P A;  4OM4 A;  1QKD A;  1KU6 B;  1CXN A;  1ES7 B;  1LXH A;  2PJY B;  1ERA A;  1CRE A;  4FAO C;  1CDR A;  2CTX A;  3QB4 B;  2ABX A;  3EVS C;  2MHY A;  1FSC A;  1CDQ A;  2QJA C;  1BTE A;  2CDX A;  2CRS A;  2MJY A;  4BIK B;  1TGX A;  3NDS A;  1REW C;  3HH7 A;  1KFH A;  2L5S A;  3VTS A;  1IQ9 A;  1ZAD A;  2MUP A;  4UY2 C;  1KXI A;  2JQP A;  1CDS A;  1MAH F;  1VB0 A;  3U73 U;  1KL8 A;  1CTX A;  1LSI A;  3KFD E;  2UX2 A;  3KFD I;  1YWH A;  1XT3 A;  1NYU A;  5EBX A;  3ERA A;  1H0J A;  2MFA A;  1BXP A;  1NTN A;  2J8B A;  1KTZ B;  5IMY C;  1PLO A;  2GOO C;  1TFS A;  4ZQY A;  1MR6 A;  1DRS A;  3EBX A;  5DO6 A;  1COD A;  2BTX A;  2FD6 U;  1F94 A;  1HC9 A;  2UWR A;  1HAJ A;  1CVO A;  1IDH A;  2H62 D;  4AEA A;  1G6M A;  1HOY A;  4RUD A;  1CDT A;  1HC9 B;  1UG4 A;  2QC1 A;  1FF4 A;  2MJ0 A;  2ERA A;  2BHI A;  1S4Y A;  1CCQ A;  2H62 C;  2LCR A;  4OM5 A;  4BDT B;  1JGK A;  1NYS A;  1HAA A;  2OFS A;  1NTX A;  4IYE A;  3PLC A;  4EY8 B;  2NBT A;  1LX5 B;  2GOO B;  1RL5 A;  1LXG A;  1IKC A;  1IDG A;  5DU1 A;  1IK8 A;  1FSS B;  1KS6 A;  3NEQ A;  1QKE A;  2QJB C;  2MJ4 A;  3FEV A;  1JE9 A;  3U74 U;  1FFJ A;  1FRA A;  4KSN A;  2VLW A;  1IDI A;  1B41 B;  2QJ9 C;  4LFT A;  1TXB A;  4DO8 A;  3NH7 A;  1ERG A;  6EBX A;  1KBA A;  1CHV S;  1L4W A;  1QM7 A;  2JVE A;  2H64 C;  4QTI U;  4XJJ A;  4HQP F;  1COE A;  2H7Z A;  1W6B A;  2CCX A;  3BT1 U;  2H5F A;  5DZ5 A;  1CXO A;  2HLR A;  2N99 A;  2LA1 A;  2H7Z B;  1ONJ A;  2PJY C;  1ABT A;  1KC4 A;  3LAQ U;  4P7U A;  2I9B E;  2CRT A;  1JBD A;  2L03 A;  1NXB A;  3BT2 U;  2HLQ A;  2H64 B;  1F8U B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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