1A16A

Aminopeptidase p from e. coli with the inhibitor pro-leu
Total Genus 152
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
152
sequence length
440
structure length
439
Chain Sequence
SEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSEYPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQLLNGLDVVYHAQGEYAYADVIVNSLEKLRKGSRQNLTAPATMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGIGIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and mechanism of a proline-specific aminopeptidase from Escherichia coli.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords AMINOPEPTIDASE P
total genus 152
structure length 439
sequence length 440
ec nomenclature ec 3.4.11.9: Xaa-Pro aminopeptidase.
pdb deposition date 1997-12-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 1a16A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1a16A02
5CIKA 1WLRA 1PV9A 4EGEA 5CNXA 1C27A 1QXYA 2GTXA 2NQ6A 4U73A 4U69A 1YVMA 1QZYA 1XGOA 3D27A 4U1BA 2IW2A 3PKCA 2BWWA 2MATA 4PNCA 4RZZA 2EA2A 5JHUA 2OAZA 1XGSA 4IKTA 2Q8KA 2BN7A 3PKBA 2EVCA 3L7GA 4R60A 2Q92A 2P99A 4MATA 2NQ7A 4U6WA 2GU4A 2B3LA 1QXWA 2BHAA 4PV4A 5D6EA 2Q93A 1YW9A 4IKRA 2Q94A 4U76A 4FUKA 5FCFA 4KM3A 1WY2A 1W2MA 2B3KA 2G6PA 2BWTA 2V3YA 4U6CA 3IG4A 3IL0A 1YW7A 1KQ9A 3FM3A 3PKEA 2GG8A 4U6ZA 2GGBA 2ADUA 4U6EA 1YJ3A 3BITA 3BIQA 2BB7A 4IKSA 4S01A 4ZWUA 1MATA 2ZSGA 2GA2A 2GU6A 2BWVA 2GG3A 3OOOA 4ZNGA 1O0XA 1XGNA 3FMRA 4U70A 1CHMA 4S00A 3RORA 3TAVA 3CTZA 3TB5A 3MATA 2OKNA 1C21A 2EVOA 1M35A 4B28A 2GGCA 4QR8A 1C24A 3MR1A 2BHDA 5JFRA 4RGZ1 3L24A 1Y1NA 2HOWA 1KQ0A 4U75A 1WL9A 1QXZA 2P9AA 3Q6DA 4FLJA 2DFIA 3CB5A 4FLIA 3QOCA 4JUQA 2BWUA 2GZ5A 2GU7A 3PN9A 3BIPA 2P98A 2V6CA 5CE6A 4HXXA 1WBQA 4IF7A 3PEBA 1BN5A 1C22A 4OOKA 3S6BA 2V3ZA 1N51A 1R58A 3RVAA 3O5VA 4IKUA 3PKAA 2V3XA 2B3HA 4Z7MA 5JI6A 2GU5A 1BOAA 1XNZA 2GG2A 3CB6A 1XGMA 4U6JA 4U71A 4IDYA 4A6WA 4FKCA 5CDEA 1R5HA 4FLLA 5D6FA 4IPAA 1W7VA 2Q96A 2EA4A 2BWXA 5FCHA 2BH3A 5CLSA 1JAWA 3I7MA 2Q95A 4A6VA 3MX6A 2GG5A 1C23A 2BHBA 3IU7A 4RZYA 1A16A 4ZWOA 1B6AA 3FMQA 3IU8A 5E2CA 2BWSA 1YW8A 2EVMA 3IU9A 3OVKA 2BWYA 4S2RP 4FLKA 4ZWPA 2GG0A 1KP0A 4IU6A 1WN1A 5E5BA 2GG7A 2BHCA 4S2TP 5CDVA 1WL6A 5CDLA 4FO8A 4FO7A 1B59A 2GG9A 4IECA 1R5GA 1WKMA 3PKDA
chains in the Genus database with same CATH superfamily
5CIKA 1WLRA 1PV9A 4EGEA 5CNXA 1C27A 1QXYA 2GTXA 2NQ6A 4U73A 4U69A 1YVMA 1QZYA 1XGOA 3D27A 4U1BA 2IW2A 3PKCA 2BWWA 2MATA 4PNCA 4RZZA 2EA2A 5JHUA 2OAZA 1XGSA 4IKTA 2Q8KA 2BN7A 3PKBA 2EVCA 3L7GA 4R60A 2Q92A 2P99A 4MATA 2NQ7A 4U6WA 2GU4A 2B3LA 1QXWA 2BHAA 4PV4A 5D6EA 2Q93A 1YW9A 4IKRA 2Q94A 4U76A 4FUKA 5FCFA 4KM3A 1WY2A 1W2MA 2B3KA 2G6PA 2BWTA 2V3YA 4U6CA 3IG4A 3IL0A 1YW7A 1KQ9A 3FM3A 3PKEA 2GG8A 4U6ZA 2GGBA 2ADUA 4U6EA 1YJ3A 3BITA 3BIQA 2BB7A 4IKSA 4S01A 4ZWUA 1MATA 2ZSGA 2GA2A 2GU6A 2BWVA 2GG3A 3OOOA 4ZNGA 1O0XA 1XGNA 3FMRA 4U70A 1CHMA 4S00A 3RORA 3TAVA 3CTZA 3TB5A 3MATA 2OKNA 1C21A 2EVOA 1M35A 4B28A 2GGCA 4QR8A 1C24A 3MR1A 2BHDA 5JFRA 4RGZ1 3L24A 1Y1NA 2HOWA 1KQ0A 4U75A 1WL9A 1QXZA 2P9AA 3Q6DA 4FLJA 2DFIA 3CB5A 4FLIA 3QOCA 4JUQA 2BWUA 2GZ5A 2GU7A 3PN9A 3BIPA 2P98A 2V6CA 5CE6A 4HXXA 1WBQA 4IF7A 3PEBA 1BN5A 1C22A 4OOKA 3S6BA 2V3ZA 1N51A 1R58A 3RVAA 3O5VA 4IKUA 3PKAA 2V3XA 2B3HA 4Z7MA 5JI6A 2GU5A 1BOAA 1XNZA 2GG2A 3CB6A 1XGMA 4U6JA 4U71A 4IDYA 4A6WA 4FKCA 5CDEA 1R5HA 4FLLA 5D6FA 4IPAA 1W7VA 2Q96A 2EA4A 2BWXA 5FCHA 2BH3A 5CLSA 1JAWA 3I7MA 2Q95A 4A6VA 3MX6A 2GG5A 1C23A 2BHBA 3IU7A 4RZYA 1A16A 4ZWOA 1B6AA 3FMQA 3IU8A 5E2CA 2BWSA 1YW8A 2EVMA 3IU9A 3OVKA 2BWYA 4S2RP 4FLKA 4ZWPA 2GG0A 1KP0A 4IU6A 1WN1A 5E5BA 2GG7A 2BHCA 4S2TP 5CDVA 1WL6A 5CDLA 4FO8A 4FO7A 1B59A 2GG9A 4IECA 1R5GA 1WKMA 3PKDA
chains in the Genus database with same CATH topology
5CIKA 1WLRA 1PV9A 4EGEA 5CNXA 1C27A 1QXYA 2GTXA 2NQ6A 4U73A 4U69A 1YVMA 1QZYA 1XGOA 3D27A 4U1BA 2IW2A 3PKCA 2BWWA 2MATA 4PNCA 4RZZA 2EA2A 5JHUA 2OAZA 1XGSA 4IKTA 2Q8KA 2BN7A 3PKBA 2EVCA 3L7GA 4R60A 2Q92A 2P99A 4MATA 2NQ7A 4U6WA 2GU4A 2B3LA 1QXWA 2BHAA 4PV4A 5D6EA 2Q93A 1YW9A 4IKRA 2Q94A 4U76A 4FUKA 5FCFA 4KM3A 1WY2A 1W2MA 2B3KA 2G6PA 2BWTA 2V3YA 4U6CA 3IG4A 3IL0A 1YW7A 1KQ9A 3FM3A 3PKEA 2GG8A 4U6ZA 2GGBA 2ADUA 4U6EA 1YJ3A 3BITA 3BIQA 2BB7A 4IKSA 4S01A 4ZWUA 1MATA 2ZSGA 2GA2A 2GU6A 2BWVA 2GG3A 3OOOA 4ZNGA 1O0XA 1XGNA 3FMRA 4U70A 1CHMA 4S00A 3RORA 3TAVA 3CTZA 3TB5A 3MATA 2OKNA 1C21A 2EVOA 1M35A 4B28A 2GGCA 4QR8A 1C24A 3MR1A 2BHDA 5JFRA 4RGZ1 3L24A 1Y1NA 2HOWA 1KQ0A 4U75A 1WL9A 1QXZA 2P9AA 3Q6DA 4FLJA 2DFIA 3CB5A 4FLIA 3QOCA 4JUQA 2BWUA 2GZ5A 2GU7A 3PN9A 3BIPA 2P98A 2V6CA 5CE6A 4HXXA 1WBQA 4IF7A 3PEBA 1BN5A 1C22A 4OOKA 3S6BA 2V3ZA 1N51A 1R58A 3RVAA 3O5VA 4IKUA 3PKAA 2V3XA 2B3HA 4Z7MA 5JI6A 2GU5A 1BOAA 1XNZA 2GG2A 3CB6A 1XGMA 4U6JA 4U71A 4IDYA 4A6WA 4FKCA 5CDEA 1R5HA 4FLLA 5D6FA 4IPAA 1W7VA 2Q96A 2EA4A 2BWXA 5FCHA 2BH3A 5CLSA 1JAWA 3I7MA 2Q95A 4A6VA 3MX6A 2GG5A 1C23A 2BHBA 3IU7A 4RZYA 1A16A 4ZWOA 1B6AA 3FMQA 3IU8A 5E2CA 2BWSA 1YW8A 2EVMA 3IU9A 3OVKA 2BWYA 4S2RP 4FLKA 4ZWPA 2GG0A 1KP0A 4IU6A 1WN1A 5E5BA 2GG7A 2BHCA 4S2TP 5CDVA 1WL6A 5CDLA 4FO8A 4FO7A 1B59A 2GG9A 4IECA 1R5GA 1WKMA 3PKDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CIK A;  1WLR A;  1PV9 A;  4EGE A;  5CNX A;  1C27 A;  1QXY A;  2GTX A;  2NQ6 A;  4U73 A;  4U69 A;  1YVM A;  1QZY A;  1XGO A;  3D27 A;  4U1B A;  2IW2 A;  3PKC A;  2BWW A;  2MAT A;  4PNC A;  4RZZ A;  2EA2 A;  5JHU A;  2OAZ A;  1XGS A;  4IKT A;  2Q8K A;  2BN7 A;  3PKB A;  2EVC A;  3L7G A;  4R60 A;  2Q92 A;  2P99 A;  4MAT A;  2NQ7 A;  4U6W A;  2GU4 A;  2B3L A;  1QXW A;  2BHA A;  4PV4 A;  5D6E A;  2Q93 A;  1YW9 A;  4IKR A;  2Q94 A;  4U76 A;  4FUK A;  5FCF A;  4KM3 A;  1WY2 A;  1W2M A;  2B3K A;  2G6P A;  2BWT A;  2V3Y A;  4U6C A;  3IG4 A;  3IL0 A;  1YW7 A;  1KQ9 A;  3FM3 A;  3PKE A;  2GG8 A;  4U6Z A;  2GGB A;  2ADU A;  4U6E A;  1YJ3 A;  3BIT A;  3BIQ A;  2BB7 A;  4IKS A;  4S01 A;  4ZWU A;  1MAT A;  2ZSG A;  2GA2 A;  2GU6 A;  2BWV A;  2GG3 A;  3OOO A;  4ZNG A;  1O0X A;  1XGN A;  3FMR A;  4U70 A;  1CHM A;  4S00 A;  3ROR A;  3TAV A;  3CTZ A;  3TB5 A;  3MAT A;  2OKN A;  1C21 A;  2EVO A;  1M35 A;  4B28 A;  2GGC A;  4QR8 A;  1C24 A;  3MR1 A;  2BHD A;  5JFR A;  4RGZ 1;  3L24 A;  1Y1N A;  2HOW A;  1KQ0 A;  4U75 A;  1WL9 A;  1QXZ A;  2P9A A;  3Q6D A;  4FLJ A;  2DFI A;  3CB5 A;  4FLI A;  3QOC A;  4JUQ A;  2BWU A;  2GZ5 A;  2GU7 A;  3PN9 A;  3BIP A;  2P98 A;  2V6C A;  5CE6 A;  4HXX A;  1WBQ A;  4IF7 A;  3PEB A;  1BN5 A;  1C22 A;  4OOK A;  3S6B A;  2V3Z A;  1N51 A;  1R58 A;  3RVA A;  3O5V A;  4IKU A;  3PKA A;  2V3X A;  2B3H A;  4Z7M A;  5JI6 A;  2GU5 A;  1BOA A;  1XNZ A;  2GG2 A;  3CB6 A;  1XGM A;  4U6J A;  4U71 A;  4IDY A;  4A6W A;  4FKC A;  5CDE A;  1R5H A;  4FLL A;  5D6F A;  4IPA A;  1W7V A;  2Q96 A;  2EA4 A;  2BWX A;  5FCH A;  2BH3 A;  5CLS A;  1JAW A;  3I7M A;  2Q95 A;  4A6V A;  3MX6 A;  2GG5 A;  1C23 A;  2BHB A;  3IU7 A;  4RZY A;  1A16 A;  4ZWO A;  1B6A A;  3FMQ A;  3IU8 A;  5E2C A;  2BWS A;  1YW8 A;  2EVM A;  3IU9 A;  3OVK A;  2BWY A;  4S2R P;  4FLK A;  4ZWP A;  2GG0 A;  1KP0 A;  4IU6 A;  1WN1 A;  5E5B A;  2GG7 A;  2BHC A;  4S2T P;  5CDV A;  1WL6 A;  5CDL A;  4FO8 A;  4FO7 A;  1B59 A;  2GG9 A;  4IEC A;  1R5G A;  1WKM A;  3PKD A; 
#chains in the Genus database with same CATH topology
 5CIK A;  1WLR A;  1PV9 A;  4EGE A;  5CNX A;  1C27 A;  1QXY A;  2GTX A;  2NQ6 A;  4U73 A;  4U69 A;  1YVM A;  1QZY A;  1XGO A;  3D27 A;  4U1B A;  2IW2 A;  3PKC A;  2BWW A;  2MAT A;  4PNC A;  4RZZ A;  2EA2 A;  5JHU A;  2OAZ A;  1XGS A;  4IKT A;  2Q8K A;  2BN7 A;  3PKB A;  2EVC A;  3L7G A;  4R60 A;  2Q92 A;  2P99 A;  4MAT A;  2NQ7 A;  4U6W A;  2GU4 A;  2B3L A;  1QXW A;  2BHA A;  4PV4 A;  5D6E A;  2Q93 A;  1YW9 A;  4IKR A;  2Q94 A;  4U76 A;  4FUK A;  5FCF A;  4KM3 A;  1WY2 A;  1W2M A;  2B3K A;  2G6P A;  2BWT A;  2V3Y A;  4U6C A;  3IG4 A;  3IL0 A;  1YW7 A;  1KQ9 A;  3FM3 A;  3PKE A;  2GG8 A;  4U6Z A;  2GGB A;  2ADU A;  4U6E A;  1YJ3 A;  3BIT A;  3BIQ A;  2BB7 A;  4IKS A;  4S01 A;  4ZWU A;  1MAT A;  2ZSG A;  2GA2 A;  2GU6 A;  2BWV A;  2GG3 A;  3OOO A;  4ZNG A;  1O0X A;  1XGN A;  3FMR A;  4U70 A;  1CHM A;  4S00 A;  3ROR A;  3TAV A;  3CTZ A;  3TB5 A;  3MAT A;  2OKN A;  1C21 A;  2EVO A;  1M35 A;  4B28 A;  2GGC A;  4QR8 A;  1C24 A;  3MR1 A;  2BHD A;  5JFR A;  4RGZ 1;  3L24 A;  1Y1N A;  2HOW A;  1KQ0 A;  4U75 A;  1WL9 A;  1QXZ A;  2P9A A;  3Q6D A;  4FLJ A;  2DFI A;  3CB5 A;  4FLI A;  3QOC A;  4JUQ A;  2BWU A;  2GZ5 A;  2GU7 A;  3PN9 A;  3BIP A;  2P98 A;  2V6C A;  5CE6 A;  4HXX A;  1WBQ A;  4IF7 A;  3PEB A;  1BN5 A;  1C22 A;  4OOK A;  3S6B A;  2V3Z A;  1N51 A;  1R58 A;  3RVA A;  3O5V A;  4IKU A;  3PKA A;  2V3X A;  2B3H A;  4Z7M A;  5JI6 A;  2GU5 A;  1BOA A;  1XNZ A;  2GG2 A;  3CB6 A;  1XGM A;  4U6J A;  4U71 A;  4IDY A;  4A6W A;  4FKC A;  5CDE A;  1R5H A;  4FLL A;  5D6F A;  4IPA A;  1W7V A;  2Q96 A;  2EA4 A;  2BWX A;  5FCH A;  2BH3 A;  5CLS A;  1JAW A;  3I7M A;  2Q95 A;  4A6V A;  3MX6 A;  2GG5 A;  1C23 A;  2BHB A;  3IU7 A;  4RZY A;  1A16 A;  4ZWO A;  1B6A A;  3FMQ A;  3IU8 A;  5E2C A;  2BWS A;  1YW8 A;  2EVM A;  3IU9 A;  3OVK A;  2BWY A;  4S2R P;  4FLK A;  4ZWP A;  2GG0 A;  1KP0 A;  4IU6 A;  1WN1 A;  5E5B A;  2GG7 A;  2BHC A;  4S2T P;  5CDV A;  1WL6 A;  5CDL A;  4FO8 A;  4FO7 A;  1B59 A;  2GG9 A;  4IEC A;  1R5G A;  1WKM A;  3PKD A; 
#chains in the Genus database with same CATH homology
 5CIK A;  1WLR A;  1PV9 A;  4EGE A;  5CNX A;  1C27 A;  1QXY A;  2GTX A;  2NQ6 A;  4U73 A;  4U69 A;  1YVM A;  1QZY A;  1XGO A;  3D27 A;  4U1B A;  2IW2 A;  3PKC A;  2BWW A;  2MAT A;  4PNC A;  4RZZ A;  2EA2 A;  5JHU A;  2OAZ A;  1XGS A;  4IKT A;  2Q8K A;  2BN7 A;  3PKB A;  2EVC A;  3L7G A;  4R60 A;  2Q92 A;  2P99 A;  4MAT A;  2NQ7 A;  4U6W A;  2GU4 A;  2B3L A;  1QXW A;  2BHA A;  4PV4 A;  5D6E A;  2Q93 A;  1YW9 A;  4IKR A;  2Q94 A;  4U76 A;  4FUK A;  5FCF A;  4KM3 A;  1WY2 A;  1W2M A;  2B3K A;  2G6P A;  2BWT A;  2V3Y A;  4U6C A;  3IG4 A;  3IL0 A;  1YW7 A;  1KQ9 A;  3FM3 A;  3PKE A;  2GG8 A;  4U6Z A;  2GGB A;  2ADU A;  4U6E A;  1YJ3 A;  3BIT A;  3BIQ A;  2BB7 A;  4IKS A;  4S01 A;  4ZWU A;  1MAT A;  2ZSG A;  2GA2 A;  2GU6 A;  2BWV A;  2GG3 A;  3OOO A;  4ZNG A;  1O0X A;  1XGN A;  3FMR A;  4U70 A;  1CHM A;  4S00 A;  3ROR A;  3TAV A;  3CTZ A;  3TB5 A;  3MAT A;  2OKN A;  1C21 A;  2EVO A;  1M35 A;  4B28 A;  2GGC A;  4QR8 A;  1C24 A;  3MR1 A;  2BHD A;  5JFR A;  4RGZ 1;  3L24 A;  1Y1N A;  2HOW A;  1KQ0 A;  4U75 A;  1WL9 A;  1QXZ A;  2P9A A;  3Q6D A;  4FLJ A;  2DFI A;  3CB5 A;  4FLI A;  3QOC A;  4JUQ A;  2BWU A;  2GZ5 A;  2GU7 A;  3PN9 A;  3BIP A;  2P98 A;  2V6C A;  5CE6 A;  4HXX A;  1WBQ A;  4IF7 A;  3PEB A;  1BN5 A;  1C22 A;  4OOK A;  3S6B A;  2V3Z A;  1N51 A;  1R58 A;  3RVA A;  3O5V A;  4IKU A;  3PKA A;  2V3X A;  2B3H A;  4Z7M A;  5JI6 A;  2GU5 A;  1BOA A;  1XNZ A;  2GG2 A;  3CB6 A;  1XGM A;  4U6J A;  4U71 A;  4IDY A;  4A6W A;  4FKC A;  5CDE A;  1R5H A;  4FLL A;  5D6F A;  4IPA A;  1W7V A;  2Q96 A;  2EA4 A;  2BWX A;  5FCH A;  2BH3 A;  5CLS A;  1JAW A;  3I7M A;  2Q95 A;  4A6V A;  3MX6 A;  2GG5 A;  1C23 A;  2BHB A;  3IU7 A;  4RZY A;  1A16 A;  4ZWO A;  1B6A A;  3FMQ A;  3IU8 A;  5E2C A;  2BWS A;  1YW8 A;  2EVM A;  3IU9 A;  3OVK A;  2BWY A;  4S2R P;  4FLK A;  4ZWP A;  2GG0 A;  1KP0 A;  4IU6 A;  1WN1 A;  5E5B A;  2GG7 A;  2BHC A;  4S2T P;  5CDV A;  1WL6 A;  5CDL A;  4FO8 A;  4FO7 A;  1B59 A;  2GG9 A;  4IEC A;  1R5G A;  1WKM A;  3PKD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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