1A16A

Aminopeptidase p from e. coli with the inhibitor pro-leu
Total Genus 152
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
152
sequence length
440
structure length
439
Chain Sequence
SEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSEYPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQLLNGLDVVYHAQGEYAYADVIVNSLEKLRKGSRQNLTAPATMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGIGIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and mechanism of a proline-specific aminopeptidase from Escherichia coli.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords AMINOPEPTIDASE P
total genus 152
structure length 439
sequence length 440
ec nomenclature ec 3.4.11.9: Xaa-Pro aminopeptidase.
pdb deposition date 1997-12-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 1a16A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1a16A02
3L7GA 1YW7A 2EVCA 1B59A 4IKRA 4IKTA 2EA2A 4EGEA 1YW9A 4RZYA 5CLSA 5CDEA 1C23A 3D27A 1WL6A 4U76A 4A6WA 3TAVA 2EA4A 4ZWUA 5CE6A 1W2MA 1BN5A 5FCHA 4JUQA 1YJ3A 1XGNA 3PKDA 3PKCA 2ZSGA 4FLLA 1WL9A 3OVKA 4IPAA 4Z7MA 5CIKA 2Q92A 2HOWA 2BB7A 3PKBA 5E5BA 2NQ7A 3CTZA 2BH3A 3PKAA 2GGCA 4S2TP 2GA2A 2BHAA 2BWUA 1QZYA 1M35A 1A16A 4FLKA 4U71A 4MATA 2B3LA 2Q8KA 3TB5A 3MX6A 5CNXA 3OOOA 4FO7A 2P9AA 1R58A 1R5GA 4IKSA 2IW2A 4HXXA 4IF7A 1WBQA 4U73A 4U6WA 3CB6A 4ZWPA 2BWVA 1C22A 2P99A 3PKEA 1CHMA 3MATA 2OKNA 5E2CA 4FLJA 2BHDA 1O0XA 2B3HA 4IU6A 2DFIA 1N51A 4S00A 5CDLA 1XGSA 5D6EA 5CDVA 4PNCA 3MR1A 1WKMA 4FLIA 4S01A 2BWSA 2GG0A 3IU8A 3BIQA 3PEBA 4FO8A 2Q93A 2OAZA 3PN9A 3IU9A 4IDYA 4OOKA 3RORA 3IU7A 1YW8A 5FCFA 2GU5A 4PV4A 4IECA 4U69A 1XGMA 4U70A 4A6VA 2V3YA 2GG3A 3CB5A 3Q6DA 1KP0A 4RGZ1 2V3XA 2P98A 5D6FA 3IG4A 2MATA 3BITA 1YVMA 1JAWA 3I7MA 4FKCA 1C21A 4U6EA 2Q95A 3L24A 3IL0A 2NQ6A 4IKUA 4U6ZA 1BOAA 1B6AA 5JHUA 2BHBA 4U75A 4U6JA 2BWXA 1XNZA 3RVAA 4QR8A 1C27A 1R5HA 2B3KA 2BWTA 3FMRA 1XGOA 1QXWA 2V3ZA 2GGBA 5JFRA 2GU7A 1W7VA 1KQ9A 3FM3A 1Y1NA 4B28A 1WN1A 2GG2A 2Q96A 1PV9A 1WLRA 2ADUA 2GU4A 2EVMA 3O5VA 2V6CA 2Q94A 4KM3A 2GTXA 2EVOA 4ZWOA 4S2RP 4RZZA 1C24A 1QXZA 3QOCA 4R60A 2BHCA 4ZNGA 2GG5A 4FUKA 4U1BA 3FMQA 1WY2A 2GU6A 2BWWA 2GG9A 2G6PA 5JI6A 1MATA 1QXYA 3BIPA 2GZ5A 4U6CA 2BN7A 3S6BA 1KQ0A 2GG7A 2BWYA 2GG8A
chains in the Genus database with same CATH superfamily
3L7GA 1YW7A 2EVCA 1B59A 4IKRA 4IKTA 2EA2A 4EGEA 1YW9A 4RZYA 5CLSA 5CDEA 1C23A 3D27A 1WL6A 4U76A 4A6WA 3TAVA 2EA4A 4ZWUA 5CE6A 1W2MA 1BN5A 5FCHA 4JUQA 1YJ3A 1XGNA 3PKDA 3PKCA 2ZSGA 4FLLA 1WL9A 3OVKA 4IPAA 4Z7MA 5CIKA 2Q92A 2HOWA 2BB7A 3PKBA 5E5BA 2NQ7A 3CTZA 2BH3A 3PKAA 2GGCA 4S2TP 2GA2A 2BHAA 2BWUA 1QZYA 1M35A 1A16A 4FLKA 4U71A 4MATA 2B3LA 2Q8KA 3TB5A 3MX6A 5CNXA 3OOOA 4FO7A 2P9AA 1R58A 1R5GA 4IKSA 2IW2A 4HXXA 4IF7A 1WBQA 4U73A 4U6WA 3CB6A 4ZWPA 2BWVA 1C22A 2P99A 3PKEA 1CHMA 3MATA 2OKNA 5E2CA 4FLJA 2BHDA 1O0XA 2B3HA 4IU6A 2DFIA 1N51A 4S00A 5CDLA 1XGSA 5D6EA 5CDVA 4PNCA 3MR1A 1WKMA 4FLIA 4S01A 2BWSA 2GG0A 3IU8A 3BIQA 3PEBA 4FO8A 2Q93A 2OAZA 3PN9A 3IU9A 4IDYA 4OOKA 3RORA 3IU7A 1YW8A 5FCFA 2GU5A 4PV4A 4IECA 4U69A 1XGMA 4U70A 4A6VA 2V3YA 2GG3A 3CB5A 3Q6DA 1KP0A 4RGZ1 2V3XA 2P98A 5D6FA 3IG4A 2MATA 3BITA 1YVMA 1JAWA 3I7MA 4FKCA 1C21A 4U6EA 2Q95A 3L24A 3IL0A 2NQ6A 4IKUA 4U6ZA 1BOAA 1B6AA 5JHUA 2BHBA 4U75A 4U6JA 2BWXA 1XNZA 3RVAA 4QR8A 1C27A 1R5HA 2B3KA 2BWTA 3FMRA 1XGOA 1QXWA 2V3ZA 2GGBA 5JFRA 2GU7A 1W7VA 1KQ9A 3FM3A 1Y1NA 4B28A 1WN1A 2GG2A 2Q96A 1PV9A 1WLRA 2ADUA 2GU4A 2EVMA 3O5VA 2V6CA 2Q94A 4KM3A 2GTXA 2EVOA 4ZWOA 4S2RP 4RZZA 1C24A 1QXZA 3QOCA 4R60A 2BHCA 4ZNGA 2GG5A 4FUKA 4U1BA 3FMQA 1WY2A 2GU6A 2BWWA 2GG9A 2G6PA 5JI6A 1MATA 1QXYA 3BIPA 2GZ5A 4U6CA 2BN7A 3S6BA 1KQ0A 2GG7A 2BWYA 2GG8A
chains in the Genus database with same CATH topology
3L7GA 1YW7A 2EVCA 1B59A 4IKRA 4IKTA 2EA2A 4EGEA 1YW9A 4RZYA 5CLSA 5CDEA 1C23A 3D27A 1WL6A 4U76A 4A6WA 3TAVA 2EA4A 4ZWUA 5CE6A 1W2MA 1BN5A 5FCHA 4JUQA 1YJ3A 1XGNA 3PKDA 3PKCA 2ZSGA 4FLLA 1WL9A 3OVKA 4IPAA 4Z7MA 5CIKA 2Q92A 2HOWA 2BB7A 3PKBA 5E5BA 2NQ7A 3CTZA 2BH3A 3PKAA 2GGCA 4S2TP 2GA2A 2BHAA 2BWUA 1QZYA 1M35A 1A16A 4FLKA 4U71A 4MATA 2B3LA 2Q8KA 3TB5A 3MX6A 5CNXA 3OOOA 4FO7A 2P9AA 1R58A 1R5GA 4IKSA 2IW2A 4HXXA 4IF7A 1WBQA 4U73A 4U6WA 3CB6A 4ZWPA 2BWVA 1C22A 2P99A 3PKEA 1CHMA 3MATA 2OKNA 5E2CA 4FLJA 2BHDA 1O0XA 2B3HA 4IU6A 2DFIA 1N51A 4S00A 5CDLA 1XGSA 5D6EA 5CDVA 4PNCA 3MR1A 1WKMA 4FLIA 4S01A 2BWSA 2GG0A 3IU8A 3BIQA 3PEBA 4FO8A 2Q93A 2OAZA 3PN9A 3IU9A 4IDYA 4OOKA 3RORA 3IU7A 1YW8A 5FCFA 2GU5A 4PV4A 4IECA 4U69A 1XGMA 4U70A 4A6VA 2V3YA 2GG3A 3CB5A 3Q6DA 1KP0A 4RGZ1 2V3XA 2P98A 5D6FA 3IG4A 2MATA 3BITA 1YVMA 1JAWA 3I7MA 4FKCA 1C21A 4U6EA 2Q95A 3L24A 3IL0A 2NQ6A 4IKUA 4U6ZA 1BOAA 1B6AA 5JHUA 2BHBA 4U75A 4U6JA 2BWXA 1XNZA 3RVAA 4QR8A 1C27A 1R5HA 2B3KA 2BWTA 3FMRA 1XGOA 1QXWA 2V3ZA 2GGBA 5JFRA 2GU7A 1W7VA 1KQ9A 3FM3A 1Y1NA 4B28A 1WN1A 2GG2A 2Q96A 1PV9A 1WLRA 2ADUA 2GU4A 2EVMA 3O5VA 2V6CA 2Q94A 4KM3A 2GTXA 2EVOA 4ZWOA 4S2RP 4RZZA 1C24A 1QXZA 3QOCA 4R60A 2BHCA 4ZNGA 2GG5A 4FUKA 4U1BA 3FMQA 1WY2A 2GU6A 2BWWA 2GG9A 2G6PA 5JI6A 1MATA 1QXYA 3BIPA 2GZ5A 4U6CA 2BN7A 3S6BA 1KQ0A 2GG7A 2BWYA 2GG8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3L7G A;  1YW7 A;  2EVC A;  1B59 A;  4IKR A;  4IKT A;  2EA2 A;  4EGE A;  1YW9 A;  4RZY A;  5CLS A;  5CDE A;  1C23 A;  3D27 A;  1WL6 A;  4U76 A;  4A6W A;  3TAV A;  2EA4 A;  4ZWU A;  5CE6 A;  1W2M A;  1BN5 A;  5FCH A;  4JUQ A;  1YJ3 A;  1XGN A;  3PKD A;  3PKC A;  2ZSG A;  4FLL A;  1WL9 A;  3OVK A;  4IPA A;  4Z7M A;  5CIK A;  2Q92 A;  2HOW A;  2BB7 A;  3PKB A;  5E5B A;  2NQ7 A;  3CTZ A;  2BH3 A;  3PKA A;  2GGC A;  4S2T P;  2GA2 A;  2BHA A;  2BWU A;  1QZY A;  1M35 A;  1A16 A;  4FLK A;  4U71 A;  4MAT A;  2B3L A;  2Q8K A;  3TB5 A;  3MX6 A;  5CNX A;  3OOO A;  4FO7 A;  2P9A A;  1R58 A;  1R5G A;  4IKS A;  2IW2 A;  4HXX A;  4IF7 A;  1WBQ A;  4U73 A;  4U6W A;  3CB6 A;  4ZWP A;  2BWV A;  1C22 A;  2P99 A;  3PKE A;  1CHM A;  3MAT A;  2OKN A;  5E2C A;  4FLJ A;  2BHD A;  1O0X A;  2B3H A;  4IU6 A;  2DFI A;  1N51 A;  4S00 A;  5CDL A;  1XGS A;  5D6E A;  5CDV A;  4PNC A;  3MR1 A;  1WKM A;  4FLI A;  4S01 A;  2BWS A;  2GG0 A;  3IU8 A;  3BIQ A;  3PEB A;  4FO8 A;  2Q93 A;  2OAZ A;  3PN9 A;  3IU9 A;  4IDY A;  4OOK A;  3ROR A;  3IU7 A;  1YW8 A;  5FCF A;  2GU5 A;  4PV4 A;  4IEC A;  4U69 A;  1XGM A;  4U70 A;  4A6V A;  2V3Y A;  2GG3 A;  3CB5 A;  3Q6D A;  1KP0 A;  4RGZ 1;  2V3X A;  2P98 A;  5D6F A;  3IG4 A;  2MAT A;  3BIT A;  1YVM A;  1JAW A;  3I7M A;  4FKC A;  1C21 A;  4U6E A;  2Q95 A;  3L24 A;  3IL0 A;  2NQ6 A;  4IKU A;  4U6Z A;  1BOA A;  1B6A A;  5JHU A;  2BHB A;  4U75 A;  4U6J A;  2BWX A;  1XNZ A;  3RVA A;  4QR8 A;  1C27 A;  1R5H A;  2B3K A;  2BWT A;  3FMR A;  1XGO A;  1QXW A;  2V3Z A;  2GGB A;  5JFR A;  2GU7 A;  1W7V A;  1KQ9 A;  3FM3 A;  1Y1N A;  4B28 A;  1WN1 A;  2GG2 A;  2Q96 A;  1PV9 A;  1WLR A;  2ADU A;  2GU4 A;  2EVM A;  3O5V A;  2V6C A;  2Q94 A;  4KM3 A;  2GTX A;  2EVO A;  4ZWO A;  4S2R P;  4RZZ A;  1C24 A;  1QXZ A;  3QOC A;  4R60 A;  2BHC A;  4ZNG A;  2GG5 A;  4FUK A;  4U1B A;  3FMQ A;  1WY2 A;  2GU6 A;  2BWW A;  2GG9 A;  2G6P A;  5JI6 A;  1MAT A;  1QXY A;  3BIP A;  2GZ5 A;  4U6C A;  2BN7 A;  3S6B A;  1KQ0 A;  2GG7 A;  2BWY A;  2GG8 A; 
#chains in the Genus database with same CATH topology
 3L7G A;  1YW7 A;  2EVC A;  1B59 A;  4IKR A;  4IKT A;  2EA2 A;  4EGE A;  1YW9 A;  4RZY A;  5CLS A;  5CDE A;  1C23 A;  3D27 A;  1WL6 A;  4U76 A;  4A6W A;  3TAV A;  2EA4 A;  4ZWU A;  5CE6 A;  1W2M A;  1BN5 A;  5FCH A;  4JUQ A;  1YJ3 A;  1XGN A;  3PKD A;  3PKC A;  2ZSG A;  4FLL A;  1WL9 A;  3OVK A;  4IPA A;  4Z7M A;  5CIK A;  2Q92 A;  2HOW A;  2BB7 A;  3PKB A;  5E5B A;  2NQ7 A;  3CTZ A;  2BH3 A;  3PKA A;  2GGC A;  4S2T P;  2GA2 A;  2BHA A;  2BWU A;  1QZY A;  1M35 A;  1A16 A;  4FLK A;  4U71 A;  4MAT A;  2B3L A;  2Q8K A;  3TB5 A;  3MX6 A;  5CNX A;  3OOO A;  4FO7 A;  2P9A A;  1R58 A;  1R5G A;  4IKS A;  2IW2 A;  4HXX A;  4IF7 A;  1WBQ A;  4U73 A;  4U6W A;  3CB6 A;  4ZWP A;  2BWV A;  1C22 A;  2P99 A;  3PKE A;  1CHM A;  3MAT A;  2OKN A;  5E2C A;  4FLJ A;  2BHD A;  1O0X A;  2B3H A;  4IU6 A;  2DFI A;  1N51 A;  4S00 A;  5CDL A;  1XGS A;  5D6E A;  5CDV A;  4PNC A;  3MR1 A;  1WKM A;  4FLI A;  4S01 A;  2BWS A;  2GG0 A;  3IU8 A;  3BIQ A;  3PEB A;  4FO8 A;  2Q93 A;  2OAZ A;  3PN9 A;  3IU9 A;  4IDY A;  4OOK A;  3ROR A;  3IU7 A;  1YW8 A;  5FCF A;  2GU5 A;  4PV4 A;  4IEC A;  4U69 A;  1XGM A;  4U70 A;  4A6V A;  2V3Y A;  2GG3 A;  3CB5 A;  3Q6D A;  1KP0 A;  4RGZ 1;  2V3X A;  2P98 A;  5D6F A;  3IG4 A;  2MAT A;  3BIT A;  1YVM A;  1JAW A;  3I7M A;  4FKC A;  1C21 A;  4U6E A;  2Q95 A;  3L24 A;  3IL0 A;  2NQ6 A;  4IKU A;  4U6Z A;  1BOA A;  1B6A A;  5JHU A;  2BHB A;  4U75 A;  4U6J A;  2BWX A;  1XNZ A;  3RVA A;  4QR8 A;  1C27 A;  1R5H A;  2B3K A;  2BWT A;  3FMR A;  1XGO A;  1QXW A;  2V3Z A;  2GGB A;  5JFR A;  2GU7 A;  1W7V A;  1KQ9 A;  3FM3 A;  1Y1N A;  4B28 A;  1WN1 A;  2GG2 A;  2Q96 A;  1PV9 A;  1WLR A;  2ADU A;  2GU4 A;  2EVM A;  3O5V A;  2V6C A;  2Q94 A;  4KM3 A;  2GTX A;  2EVO A;  4ZWO A;  4S2R P;  4RZZ A;  1C24 A;  1QXZ A;  3QOC A;  4R60 A;  2BHC A;  4ZNG A;  2GG5 A;  4FUK A;  4U1B A;  3FMQ A;  1WY2 A;  2GU6 A;  2BWW A;  2GG9 A;  2G6P A;  5JI6 A;  1MAT A;  1QXY A;  3BIP A;  2GZ5 A;  4U6C A;  2BN7 A;  3S6B A;  1KQ0 A;  2GG7 A;  2BWY A;  2GG8 A; 
#chains in the Genus database with same CATH homology
 3L7G A;  1YW7 A;  2EVC A;  1B59 A;  4IKR A;  4IKT A;  2EA2 A;  4EGE A;  1YW9 A;  4RZY A;  5CLS A;  5CDE A;  1C23 A;  3D27 A;  1WL6 A;  4U76 A;  4A6W A;  3TAV A;  2EA4 A;  4ZWU A;  5CE6 A;  1W2M A;  1BN5 A;  5FCH A;  4JUQ A;  1YJ3 A;  1XGN A;  3PKD A;  3PKC A;  2ZSG A;  4FLL A;  1WL9 A;  3OVK A;  4IPA A;  4Z7M A;  5CIK A;  2Q92 A;  2HOW A;  2BB7 A;  3PKB A;  5E5B A;  2NQ7 A;  3CTZ A;  2BH3 A;  3PKA A;  2GGC A;  4S2T P;  2GA2 A;  2BHA A;  2BWU A;  1QZY A;  1M35 A;  1A16 A;  4FLK A;  4U71 A;  4MAT A;  2B3L A;  2Q8K A;  3TB5 A;  3MX6 A;  5CNX A;  3OOO A;  4FO7 A;  2P9A A;  1R58 A;  1R5G A;  4IKS A;  2IW2 A;  4HXX A;  4IF7 A;  1WBQ A;  4U73 A;  4U6W A;  3CB6 A;  4ZWP A;  2BWV A;  1C22 A;  2P99 A;  3PKE A;  1CHM A;  3MAT A;  2OKN A;  5E2C A;  4FLJ A;  2BHD A;  1O0X A;  2B3H A;  4IU6 A;  2DFI A;  1N51 A;  4S00 A;  5CDL A;  1XGS A;  5D6E A;  5CDV A;  4PNC A;  3MR1 A;  1WKM A;  4FLI A;  4S01 A;  2BWS A;  2GG0 A;  3IU8 A;  3BIQ A;  3PEB A;  4FO8 A;  2Q93 A;  2OAZ A;  3PN9 A;  3IU9 A;  4IDY A;  4OOK A;  3ROR A;  3IU7 A;  1YW8 A;  5FCF A;  2GU5 A;  4PV4 A;  4IEC A;  4U69 A;  1XGM A;  4U70 A;  4A6V A;  2V3Y A;  2GG3 A;  3CB5 A;  3Q6D A;  1KP0 A;  4RGZ 1;  2V3X A;  2P98 A;  5D6F A;  3IG4 A;  2MAT A;  3BIT A;  1YVM A;  1JAW A;  3I7M A;  4FKC A;  1C21 A;  4U6E A;  2Q95 A;  3L24 A;  3IL0 A;  2NQ6 A;  4IKU A;  4U6Z A;  1BOA A;  1B6A A;  5JHU A;  2BHB A;  4U75 A;  4U6J A;  2BWX A;  1XNZ A;  3RVA A;  4QR8 A;  1C27 A;  1R5H A;  2B3K A;  2BWT A;  3FMR A;  1XGO A;  1QXW A;  2V3Z A;  2GGB A;  5JFR A;  2GU7 A;  1W7V A;  1KQ9 A;  3FM3 A;  1Y1N A;  4B28 A;  1WN1 A;  2GG2 A;  2Q96 A;  1PV9 A;  1WLR A;  2ADU A;  2GU4 A;  2EVM A;  3O5V A;  2V6C A;  2Q94 A;  4KM3 A;  2GTX A;  2EVO A;  4ZWO A;  4S2R P;  4RZZ A;  1C24 A;  1QXZ A;  3QOC A;  4R60 A;  2BHC A;  4ZNG A;  2GG5 A;  4FUK A;  4U1B A;  3FMQ A;  1WY2 A;  2GU6 A;  2BWW A;  2GG9 A;  2G6P A;  5JI6 A;  1MAT A;  1QXY A;  3BIP A;  2GZ5 A;  4U6C A;  2BN7 A;  3S6B A;  1KQ0 A;  2GG7 A;  2BWY A;  2GG8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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