2BWSA

His243ala escherichia coli aminopeptidase p
Total Genus 160
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
sequence length
440
structure length
439
Chain Sequence
SEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSEYPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQLLNGLDVVYHAQGEYAYADVIVNSALEKLRKGSRQNLTAPATMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGCILAYTENEEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGIGIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Kinetic and Crystallographic Analysis of Mutant Escherichia Coli Aminopeptidase P: Insights Into Substrate Recognition and the Mechanism of Catalysis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords XAA-PRO AMINOPEPTIDASE P
total genus 160
structure length 439
sequence length 440
ec nomenclature ec 3.4.11.9: Xaa-Pro aminopeptidase.
pdb deposition date 2005-07-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2bwsA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2bwsA02
3IL0A 5CDEA 3Q6DA 1XGNA 1WN1A 5JFRA 2BB7A 1C21A 4FLLA 4S2RP 3PKCA 2EA2A 4R60A 5CLSA 3OOOA 1QXZA 5CE6A 3BIQA 1R5GA 3PKAA 2B3HA 2BHAA 4KM3A 5JHUA 5FCHA 5JI6A 4IKSA 4HXXA 3PKDA 4FLJA 4U6EA 1C27A 3BITA 1A16A 3QOCA 2Q93A 1YW8A 4JUQA 4OOKA 4S00A 2BWUA 4U73A 3BIPA 4ZNGA 4U71A 4RGZ1 1WY2A 1W7VA 4U6WA 1PV9A 2BH3A 1R58A 4U1BA 3PKEA 3FMRA 2EVCA 1QZYA 3IU9A 3MATA 4ZWOA 4PNCA 1O0XA 1W2MA 3MR1A 4U6JA 2V6CA 2OAZA 3IU7A 1KQ9A 1B6AA 2P98A 2HOWA 1QXYA 4IKUA 2GA2A 4U76A 3I7MA 5CNXA 4IECA 1CHMA 2ZSGA 1C22A 1R5HA 2V3YA 2GG9A 2GU6A 2GG2A 2GGCA 2GZ5A 4A6WA 3PKBA 2Q96A 2GU7A 4ZWUA 2BWSA 2DFIA 1YW9A 2V3XA 3CTZA 4RZZA 4B28A 3IG4A 3IU8A 4U69A 4FKCA 3D27A 4Z7MA 1MATA 2ADUA 4IPAA 5E2CA 2V3ZA 4QR8A 1C23A 2MATA 2EVOA 5CDLA 1KQ0A 2GU5A 3L24A 3OVKA 4IDYA 2BWWA 4S01A 1B59A 1C24A 3MX6A 1Y1NA 2Q95A 5D6FA 3PEBA 4IKTA 2EVMA 3RVAA 3TAVA 2BWTA 2P99A 2GG5A 4A6VA 1M35A 1XNZA 2B3LA 2GG8A 5E5BA 2BWXA 4IU6A 3TB5A 2BWVA 2BHCA 1YJ3A 2NQ7A 2P9AA 3FMQA 1WL6A 2GG0A 4FO7A 2BN7A 1WLRA 3CB6A 4U75A 4PV4A 4FUKA 2BHDA 4U6ZA 2NQ6A 4RZYA 4U6CA 4MATA 2OKNA 5FCFA 2BWYA 5CDVA 2Q94A 2EA4A 4FO8A 1WKMA 4FLIA 1XGOA 2BHBA 1XGSA 4S2TP 1YVMA 2Q92A 3CB5A 2GGBA 5D6EA 1WL9A 1BOAA 4EGEA 2IW2A 2GG3A 3O5VA 2G6PA 1BN5A 1QXWA 1JAWA 4FLKA 3S6BA 4ZWPA 1YW7A 2GTXA 2Q8KA 3PN9A 1XGMA 4IKRA 1KP0A 2B3KA 4U70A 2GG7A 4IF7A 5CIKA 3L7GA 3FM3A 3RORA 2GU4A 1WBQA 1N51A
chains in the Genus database with same CATH superfamily
3IL0A 5CDEA 3Q6DA 1XGNA 1WN1A 5JFRA 2BB7A 1C21A 4FLLA 4S2RP 3PKCA 2EA2A 4R60A 5CLSA 3OOOA 1QXZA 5CE6A 3BIQA 1R5GA 3PKAA 2B3HA 2BHAA 4KM3A 5JHUA 5FCHA 5JI6A 4IKSA 4HXXA 3PKDA 4FLJA 4U6EA 1C27A 3BITA 1A16A 3QOCA 2Q93A 1YW8A 4JUQA 4OOKA 4S00A 2BWUA 4U73A 3BIPA 4ZNGA 4U71A 4RGZ1 1WY2A 1W7VA 4U6WA 1PV9A 2BH3A 1R58A 4U1BA 3PKEA 3FMRA 2EVCA 1QZYA 3IU9A 3MATA 4ZWOA 4PNCA 1O0XA 1W2MA 3MR1A 4U6JA 2V6CA 2OAZA 3IU7A 1KQ9A 1B6AA 2P98A 2HOWA 1QXYA 4IKUA 2GA2A 4U76A 3I7MA 5CNXA 4IECA 1CHMA 2ZSGA 1C22A 1R5HA 2V3YA 2GG9A 2GU6A 2GG2A 2GGCA 2GZ5A 4A6WA 3PKBA 2Q96A 2GU7A 4ZWUA 2BWSA 2DFIA 1YW9A 2V3XA 3CTZA 4RZZA 4B28A 3IG4A 3IU8A 4U69A 4FKCA 3D27A 4Z7MA 1MATA 2ADUA 4IPAA 5E2CA 2V3ZA 4QR8A 1C23A 2MATA 2EVOA 5CDLA 1KQ0A 2GU5A 3L24A 3OVKA 4IDYA 2BWWA 4S01A 1B59A 1C24A 3MX6A 1Y1NA 2Q95A 5D6FA 3PEBA 4IKTA 2EVMA 3RVAA 3TAVA 2BWTA 2P99A 2GG5A 4A6VA 1M35A 1XNZA 2B3LA 2GG8A 5E5BA 2BWXA 4IU6A 3TB5A 2BWVA 2BHCA 1YJ3A 2NQ7A 2P9AA 3FMQA 1WL6A 2GG0A 4FO7A 2BN7A 1WLRA 3CB6A 4U75A 4PV4A 4FUKA 2BHDA 4U6ZA 2NQ6A 4RZYA 4U6CA 4MATA 2OKNA 5FCFA 2BWYA 5CDVA 2Q94A 2EA4A 4FO8A 1WKMA 4FLIA 1XGOA 2BHBA 1XGSA 4S2TP 1YVMA 2Q92A 3CB5A 2GGBA 5D6EA 1WL9A 1BOAA 4EGEA 2IW2A 2GG3A 3O5VA 2G6PA 1BN5A 1QXWA 1JAWA 4FLKA 3S6BA 4ZWPA 1YW7A 2GTXA 2Q8KA 3PN9A 1XGMA 4IKRA 1KP0A 2B3KA 4U70A 2GG7A 4IF7A 5CIKA 3L7GA 3FM3A 3RORA 2GU4A 1WBQA 1N51A
chains in the Genus database with same CATH topology
3IL0A 5CDEA 3Q6DA 1XGNA 1WN1A 5JFRA 2BB7A 1C21A 4FLLA 4S2RP 3PKCA 2EA2A 4R60A 5CLSA 3OOOA 1QXZA 5CE6A 3BIQA 1R5GA 3PKAA 2B3HA 2BHAA 4KM3A 5JHUA 5FCHA 5JI6A 4IKSA 4HXXA 3PKDA 4FLJA 4U6EA 1C27A 3BITA 1A16A 3QOCA 2Q93A 1YW8A 4JUQA 4OOKA 4S00A 2BWUA 4U73A 3BIPA 4ZNGA 4U71A 4RGZ1 1WY2A 1W7VA 4U6WA 1PV9A 2BH3A 1R58A 4U1BA 3PKEA 3FMRA 2EVCA 1QZYA 3IU9A 3MATA 4ZWOA 4PNCA 1O0XA 1W2MA 3MR1A 4U6JA 2V6CA 2OAZA 3IU7A 1KQ9A 1B6AA 2P98A 2HOWA 1QXYA 4IKUA 2GA2A 4U76A 3I7MA 5CNXA 4IECA 1CHMA 2ZSGA 1C22A 1R5HA 2V3YA 2GG9A 2GU6A 2GG2A 2GGCA 2GZ5A 4A6WA 3PKBA 2Q96A 2GU7A 4ZWUA 2BWSA 2DFIA 1YW9A 2V3XA 3CTZA 4RZZA 4B28A 3IG4A 3IU8A 4U69A 4FKCA 3D27A 4Z7MA 1MATA 2ADUA 4IPAA 5E2CA 2V3ZA 4QR8A 1C23A 2MATA 2EVOA 5CDLA 1KQ0A 2GU5A 3L24A 3OVKA 4IDYA 2BWWA 4S01A 1B59A 1C24A 3MX6A 1Y1NA 2Q95A 5D6FA 3PEBA 4IKTA 2EVMA 3RVAA 3TAVA 2BWTA 2P99A 2GG5A 4A6VA 1M35A 1XNZA 2B3LA 2GG8A 5E5BA 2BWXA 4IU6A 3TB5A 2BWVA 2BHCA 1YJ3A 2NQ7A 2P9AA 3FMQA 1WL6A 2GG0A 4FO7A 2BN7A 1WLRA 3CB6A 4U75A 4PV4A 4FUKA 2BHDA 4U6ZA 2NQ6A 4RZYA 4U6CA 4MATA 2OKNA 5FCFA 2BWYA 5CDVA 2Q94A 2EA4A 4FO8A 1WKMA 4FLIA 1XGOA 2BHBA 1XGSA 4S2TP 1YVMA 2Q92A 3CB5A 2GGBA 5D6EA 1WL9A 1BOAA 4EGEA 2IW2A 2GG3A 3O5VA 2G6PA 1BN5A 1QXWA 1JAWA 4FLKA 3S6BA 4ZWPA 1YW7A 2GTXA 2Q8KA 3PN9A 1XGMA 4IKRA 1KP0A 2B3KA 4U70A 2GG7A 4IF7A 5CIKA 3L7GA 3FM3A 3RORA 2GU4A 1WBQA 1N51A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IL0 A;  5CDE A;  3Q6D A;  1XGN A;  1WN1 A;  5JFR A;  2BB7 A;  1C21 A;  4FLL A;  4S2R P;  3PKC A;  2EA2 A;  4R60 A;  5CLS A;  3OOO A;  1QXZ A;  5CE6 A;  3BIQ A;  1R5G A;  3PKA A;  2B3H A;  2BHA A;  4KM3 A;  5JHU A;  5FCH A;  5JI6 A;  4IKS A;  4HXX A;  3PKD A;  4FLJ A;  4U6E A;  1C27 A;  3BIT A;  1A16 A;  3QOC A;  2Q93 A;  1YW8 A;  4JUQ A;  4OOK A;  4S00 A;  2BWU A;  4U73 A;  3BIP A;  4ZNG A;  4U71 A;  4RGZ 1;  1WY2 A;  1W7V A;  4U6W A;  1PV9 A;  2BH3 A;  1R58 A;  4U1B A;  3PKE A;  3FMR A;  2EVC A;  1QZY A;  3IU9 A;  3MAT A;  4ZWO A;  4PNC A;  1O0X A;  1W2M A;  3MR1 A;  4U6J A;  2V6C A;  2OAZ A;  3IU7 A;  1KQ9 A;  1B6A A;  2P98 A;  2HOW A;  1QXY A;  4IKU A;  2GA2 A;  4U76 A;  3I7M A;  5CNX A;  4IEC A;  1CHM A;  2ZSG A;  1C22 A;  1R5H A;  2V3Y A;  2GG9 A;  2GU6 A;  2GG2 A;  2GGC A;  2GZ5 A;  4A6W A;  3PKB A;  2Q96 A;  2GU7 A;  4ZWU A;  2BWS A;  2DFI A;  1YW9 A;  2V3X A;  3CTZ A;  4RZZ A;  4B28 A;  3IG4 A;  3IU8 A;  4U69 A;  4FKC A;  3D27 A;  4Z7M A;  1MAT A;  2ADU A;  4IPA A;  5E2C A;  2V3Z A;  4QR8 A;  1C23 A;  2MAT A;  2EVO A;  5CDL A;  1KQ0 A;  2GU5 A;  3L24 A;  3OVK A;  4IDY A;  2BWW A;  4S01 A;  1B59 A;  1C24 A;  3MX6 A;  1Y1N A;  2Q95 A;  5D6F A;  3PEB A;  4IKT A;  2EVM A;  3RVA A;  3TAV A;  2BWT A;  2P99 A;  2GG5 A;  4A6V A;  1M35 A;  1XNZ A;  2B3L A;  2GG8 A;  5E5B A;  2BWX A;  4IU6 A;  3TB5 A;  2BWV A;  2BHC A;  1YJ3 A;  2NQ7 A;  2P9A A;  3FMQ A;  1WL6 A;  2GG0 A;  4FO7 A;  2BN7 A;  1WLR A;  3CB6 A;  4U75 A;  4PV4 A;  4FUK A;  2BHD A;  4U6Z A;  2NQ6 A;  4RZY A;  4U6C A;  4MAT A;  2OKN A;  5FCF A;  2BWY A;  5CDV A;  2Q94 A;  2EA4 A;  4FO8 A;  1WKM A;  4FLI A;  1XGO A;  2BHB A;  1XGS A;  4S2T P;  1YVM A;  2Q92 A;  3CB5 A;  2GGB A;  5D6E A;  1WL9 A;  1BOA A;  4EGE A;  2IW2 A;  2GG3 A;  3O5V A;  2G6P A;  1BN5 A;  1QXW A;  1JAW A;  4FLK A;  3S6B A;  4ZWP A;  1YW7 A;  2GTX A;  2Q8K A;  3PN9 A;  1XGM A;  4IKR A;  1KP0 A;  2B3K A;  4U70 A;  2GG7 A;  4IF7 A;  5CIK A;  3L7G A;  3FM3 A;  3ROR A;  2GU4 A;  1WBQ A;  1N51 A; 
#chains in the Genus database with same CATH topology
 3IL0 A;  5CDE A;  3Q6D A;  1XGN A;  1WN1 A;  5JFR A;  2BB7 A;  1C21 A;  4FLL A;  4S2R P;  3PKC A;  2EA2 A;  4R60 A;  5CLS A;  3OOO A;  1QXZ A;  5CE6 A;  3BIQ A;  1R5G A;  3PKA A;  2B3H A;  2BHA A;  4KM3 A;  5JHU A;  5FCH A;  5JI6 A;  4IKS A;  4HXX A;  3PKD A;  4FLJ A;  4U6E A;  1C27 A;  3BIT A;  1A16 A;  3QOC A;  2Q93 A;  1YW8 A;  4JUQ A;  4OOK A;  4S00 A;  2BWU A;  4U73 A;  3BIP A;  4ZNG A;  4U71 A;  4RGZ 1;  1WY2 A;  1W7V A;  4U6W A;  1PV9 A;  2BH3 A;  1R58 A;  4U1B A;  3PKE A;  3FMR A;  2EVC A;  1QZY A;  3IU9 A;  3MAT A;  4ZWO A;  4PNC A;  1O0X A;  1W2M A;  3MR1 A;  4U6J A;  2V6C A;  2OAZ A;  3IU7 A;  1KQ9 A;  1B6A A;  2P98 A;  2HOW A;  1QXY A;  4IKU A;  2GA2 A;  4U76 A;  3I7M A;  5CNX A;  4IEC A;  1CHM A;  2ZSG A;  1C22 A;  1R5H A;  2V3Y A;  2GG9 A;  2GU6 A;  2GG2 A;  2GGC A;  2GZ5 A;  4A6W A;  3PKB A;  2Q96 A;  2GU7 A;  4ZWU A;  2BWS A;  2DFI A;  1YW9 A;  2V3X A;  3CTZ A;  4RZZ A;  4B28 A;  3IG4 A;  3IU8 A;  4U69 A;  4FKC A;  3D27 A;  4Z7M A;  1MAT A;  2ADU A;  4IPA A;  5E2C A;  2V3Z A;  4QR8 A;  1C23 A;  2MAT A;  2EVO A;  5CDL A;  1KQ0 A;  2GU5 A;  3L24 A;  3OVK A;  4IDY A;  2BWW A;  4S01 A;  1B59 A;  1C24 A;  3MX6 A;  1Y1N A;  2Q95 A;  5D6F A;  3PEB A;  4IKT A;  2EVM A;  3RVA A;  3TAV A;  2BWT A;  2P99 A;  2GG5 A;  4A6V A;  1M35 A;  1XNZ A;  2B3L A;  2GG8 A;  5E5B A;  2BWX A;  4IU6 A;  3TB5 A;  2BWV A;  2BHC A;  1YJ3 A;  2NQ7 A;  2P9A A;  3FMQ A;  1WL6 A;  2GG0 A;  4FO7 A;  2BN7 A;  1WLR A;  3CB6 A;  4U75 A;  4PV4 A;  4FUK A;  2BHD A;  4U6Z A;  2NQ6 A;  4RZY A;  4U6C A;  4MAT A;  2OKN A;  5FCF A;  2BWY A;  5CDV A;  2Q94 A;  2EA4 A;  4FO8 A;  1WKM A;  4FLI A;  1XGO A;  2BHB A;  1XGS A;  4S2T P;  1YVM A;  2Q92 A;  3CB5 A;  2GGB A;  5D6E A;  1WL9 A;  1BOA A;  4EGE A;  2IW2 A;  2GG3 A;  3O5V A;  2G6P A;  1BN5 A;  1QXW A;  1JAW A;  4FLK A;  3S6B A;  4ZWP A;  1YW7 A;  2GTX A;  2Q8K A;  3PN9 A;  1XGM A;  4IKR A;  1KP0 A;  2B3K A;  4U70 A;  2GG7 A;  4IF7 A;  5CIK A;  3L7G A;  3FM3 A;  3ROR A;  2GU4 A;  1WBQ A;  1N51 A; 
#chains in the Genus database with same CATH homology
 3IL0 A;  5CDE A;  3Q6D A;  1XGN A;  1WN1 A;  5JFR A;  2BB7 A;  1C21 A;  4FLL A;  4S2R P;  3PKC A;  2EA2 A;  4R60 A;  5CLS A;  3OOO A;  1QXZ A;  5CE6 A;  3BIQ A;  1R5G A;  3PKA A;  2B3H A;  2BHA A;  4KM3 A;  5JHU A;  5FCH A;  5JI6 A;  4IKS A;  4HXX A;  3PKD A;  4FLJ A;  4U6E A;  1C27 A;  3BIT A;  1A16 A;  3QOC A;  2Q93 A;  1YW8 A;  4JUQ A;  4OOK A;  4S00 A;  2BWU A;  4U73 A;  3BIP A;  4ZNG A;  4U71 A;  4RGZ 1;  1WY2 A;  1W7V A;  4U6W A;  1PV9 A;  2BH3 A;  1R58 A;  4U1B A;  3PKE A;  3FMR A;  2EVC A;  1QZY A;  3IU9 A;  3MAT A;  4ZWO A;  4PNC A;  1O0X A;  1W2M A;  3MR1 A;  4U6J A;  2V6C A;  2OAZ A;  3IU7 A;  1KQ9 A;  1B6A A;  2P98 A;  2HOW A;  1QXY A;  4IKU A;  2GA2 A;  4U76 A;  3I7M A;  5CNX A;  4IEC A;  1CHM A;  2ZSG A;  1C22 A;  1R5H A;  2V3Y A;  2GG9 A;  2GU6 A;  2GG2 A;  2GGC A;  2GZ5 A;  4A6W A;  3PKB A;  2Q96 A;  2GU7 A;  4ZWU A;  2BWS A;  2DFI A;  1YW9 A;  2V3X A;  3CTZ A;  4RZZ A;  4B28 A;  3IG4 A;  3IU8 A;  4U69 A;  4FKC A;  3D27 A;  4Z7M A;  1MAT A;  2ADU A;  4IPA A;  5E2C A;  2V3Z A;  4QR8 A;  1C23 A;  2MAT A;  2EVO A;  5CDL A;  1KQ0 A;  2GU5 A;  3L24 A;  3OVK A;  4IDY A;  2BWW A;  4S01 A;  1B59 A;  1C24 A;  3MX6 A;  1Y1N A;  2Q95 A;  5D6F A;  3PEB A;  4IKT A;  2EVM A;  3RVA A;  3TAV A;  2BWT A;  2P99 A;  2GG5 A;  4A6V A;  1M35 A;  1XNZ A;  2B3L A;  2GG8 A;  5E5B A;  2BWX A;  4IU6 A;  3TB5 A;  2BWV A;  2BHC A;  1YJ3 A;  2NQ7 A;  2P9A A;  3FMQ A;  1WL6 A;  2GG0 A;  4FO7 A;  2BN7 A;  1WLR A;  3CB6 A;  4U75 A;  4PV4 A;  4FUK A;  2BHD A;  4U6Z A;  2NQ6 A;  4RZY A;  4U6C A;  4MAT A;  2OKN A;  5FCF A;  2BWY A;  5CDV A;  2Q94 A;  2EA4 A;  4FO8 A;  1WKM A;  4FLI A;  1XGO A;  2BHB A;  1XGS A;  4S2T P;  1YVM A;  2Q92 A;  3CB5 A;  2GGB A;  5D6E A;  1WL9 A;  1BOA A;  4EGE A;  2IW2 A;  2GG3 A;  3O5V A;  2G6P A;  1BN5 A;  1QXW A;  1JAW A;  4FLK A;  3S6B A;  4ZWP A;  1YW7 A;  2GTX A;  2Q8K A;  3PN9 A;  1XGM A;  4IKR A;  1KP0 A;  2B3K A;  4U70 A;  2GG7 A;  4IF7 A;  5CIK A;  3L7G A;  3FM3 A;  3ROR A;  2GU4 A;  1WBQ A;  1N51 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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