4EGEA

Crystal structure of dipeptidase pepe from mycobacterium ulcerans
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
371
structure length
371
Chain Sequence
GRFDTAVYARRLAAAAAATEQAGLAGLVITPGYDLRYLIGSRADTFERLTALVLPASGVPTIVLPRLELASLKESAASDLGVCVRDWVDGDDPYQLVAVALGGAPAATAVTDSMPALHLLPLADALGVLPVLATDVLRQLRMVKEAAEVDALAKAGAAIDRVHARVPAFLVPGRTEAQVAADIAEAIVAEGHSAVAFVIVGSGPHGADPHHGYSDRKLQVGDIVVVDIGGTYEPGYYSDSTRTYSIGDPSPDVAQQYSALQRAQRAAVDAVRPGVTAAQVDAAARDVLADAGLAEYFVHRTGHGIGLCVHEEPYIVAGNELPLVAGMAFSIEPGIYFPGRWGARIEDIVVVTENGALSVNNRPHELMVVPV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium ulcerans
molecule tags Hydrolase
molecule keywords Dipeptidase PepE
total genus 124
structure length 371
sequence length 371
ec nomenclature
pdb deposition date 2012-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF01321 Creatinase_N Creatinase/Prolidase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4egeA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4egeA02
2BWYA 4FKCA 1WKMA 5JFRA 1R58A 3FMQA 4U6CA 4U70A 5FCFA 1B59A 1WY2A 1CHMA 4U69A 2GG5A 5D6FA 2BWXA 4FUKA 2EVMA 1C27A 3PKBA 1YW8A 4U6JA 3S6BA 3PKEA 2MATA 1C24A 4S2TP 3OOOA 1W2MA 5CNXA 2GG2A 4U6EA 2BWSA 5FCHA 2NQ7A 2GG8A 2Q96A 2V3XA 2V3YA 1QXZA 1M35A 1R5HA 3MX6A 4HXXA 1W7VA 2BHBA 5CDVA 4PV4A 4IKSA 1KP0A 2BWTA 4U6WA 4IU6A 1JAWA 1MATA 4A6VA 2GG9A 4U71A 2GTXA 4JUQA 4FO8A 5CE6A 5JI6A 2Q8KA 4FLJA 1WN1A 4FLKA 1XNZA 2GA2A 1C23A 1A16A 3BIQA 2BH3A 2BWUA 1YJ3A 1XGNA 1B6AA 1C22A 3IU7A 4FO7A 1Y1NA 2EVOA 2B3LA 3RORA 3O5VA 2GGBA 2GU7A 2GU6A 5CIKA 2BHAA 4MATA 4OOKA 1WBQA 2B3HA 4IDYA 3IL0A 4U6ZA 1YW7A 3L7GA 1WLRA 4R60A 2ZSGA 3CB5A 1YW9A 3RVAA 3MATA 4FLLA 2Q92A 3MR1A 5JHUA 2P99A 3OVKA 2BWVA 4QR8A 2V3ZA 2GZ5A 2BWWA 4RZYA 1C21A 2EA2A 2HOWA 4U73A 1XGSA 2EA4A 2GU5A 3Q6DA 2IW2A 3PKCA 2NQ6A 5E2CA 5E5BA 3CTZA 3PKAA 4IF7A 4PNCA 2ADUA 3TAVA 1XGMA 4RGZ1 4ZWPA 3IU9A 4ZWUA 2GGCA 1YVMA 1QXWA 2BB7A 3L24A 1WL9A 4EGEA 3BITA 1BN5A 2BN7A 3CB6A 2OKNA 4FLIA 3FMRA 2Q93A 5CLSA 3BIPA 5CDEA 2V6CA 4IECA 4Z7MA 2GG0A 4IPAA 2B3KA 4KM3A 1XGOA 4A6WA 1KQ0A 2GG3A 4RZZA 5CDLA 3IG4A 4ZNGA 1BOAA 2EVCA 3IU8A 2GG7A 4U76A 4IKTA 2Q95A 5D6EA 4U75A 2P9AA 3TB5A 4B28A 4U1BA 2P98A 1R5GA 1KQ9A 2OAZA 3D27A 4IKRA 3QOCA 3FM3A 1QZYA 2GU4A 2BHDA 4S00A 2BHCA 1QXYA 1N51A 1WL6A 4S01A 2DFIA 3PEBA 2Q94A 2G6PA 3PN9A 3I7MA 4IKUA 4S2RP 1PV9A 1O0XA 3PKDA 4ZWOA
chains in the Genus database with same CATH superfamily
2BWYA 4FKCA 1WKMA 5JFRA 1R58A 3FMQA 4U6CA 4U70A 5FCFA 1B59A 1WY2A 1CHMA 4U69A 2GG5A 5D6FA 2BWXA 4FUKA 2EVMA 1C27A 3PKBA 1YW8A 4U6JA 3S6BA 3PKEA 2MATA 1C24A 4S2TP 3OOOA 1W2MA 5CNXA 2GG2A 4U6EA 2BWSA 5FCHA 2NQ7A 2GG8A 2Q96A 2V3XA 2V3YA 1QXZA 1M35A 1R5HA 3MX6A 4HXXA 1W7VA 2BHBA 5CDVA 4PV4A 4IKSA 1KP0A 2BWTA 4U6WA 4IU6A 1JAWA 1MATA 4A6VA 2GG9A 4U71A 2GTXA 4JUQA 4FO8A 5CE6A 5JI6A 2Q8KA 4FLJA 1WN1A 4FLKA 1XNZA 2GA2A 1C23A 1A16A 3BIQA 2BH3A 2BWUA 1YJ3A 1XGNA 1B6AA 1C22A 3IU7A 4FO7A 1Y1NA 2EVOA 2B3LA 3RORA 3O5VA 2GGBA 2GU7A 2GU6A 5CIKA 2BHAA 4MATA 4OOKA 1WBQA 2B3HA 4IDYA 3IL0A 4U6ZA 1YW7A 3L7GA 1WLRA 4R60A 2ZSGA 3CB5A 1YW9A 3RVAA 3MATA 4FLLA 2Q92A 3MR1A 5JHUA 2P99A 3OVKA 2BWVA 4QR8A 2V3ZA 2GZ5A 2BWWA 4RZYA 1C21A 2EA2A 2HOWA 4U73A 1XGSA 2EA4A 2GU5A 3Q6DA 2IW2A 3PKCA 2NQ6A 5E2CA 5E5BA 3CTZA 3PKAA 4IF7A 4PNCA 2ADUA 3TAVA 1XGMA 4RGZ1 4ZWPA 3IU9A 4ZWUA 2GGCA 1YVMA 1QXWA 2BB7A 3L24A 1WL9A 4EGEA 3BITA 1BN5A 2BN7A 3CB6A 2OKNA 4FLIA 3FMRA 2Q93A 5CLSA 3BIPA 5CDEA 2V6CA 4IECA 4Z7MA 2GG0A 4IPAA 2B3KA 4KM3A 1XGOA 4A6WA 1KQ0A 2GG3A 4RZZA 5CDLA 3IG4A 4ZNGA 1BOAA 2EVCA 3IU8A 2GG7A 4U76A 4IKTA 2Q95A 5D6EA 4U75A 2P9AA 3TB5A 4B28A 4U1BA 2P98A 1R5GA 1KQ9A 2OAZA 3D27A 4IKRA 3QOCA 3FM3A 1QZYA 2GU4A 2BHDA 4S00A 2BHCA 1QXYA 1N51A 1WL6A 4S01A 2DFIA 3PEBA 2Q94A 2G6PA 3PN9A 3I7MA 4IKUA 4S2RP 1PV9A 1O0XA 3PKDA 4ZWOA
chains in the Genus database with same CATH topology
2BWYA 4FKCA 1WKMA 5JFRA 1R58A 3FMQA 4U6CA 4U70A 5FCFA 1B59A 1WY2A 1CHMA 4U69A 2GG5A 5D6FA 2BWXA 4FUKA 2EVMA 1C27A 3PKBA 1YW8A 4U6JA 3S6BA 3PKEA 2MATA 1C24A 4S2TP 3OOOA 1W2MA 5CNXA 2GG2A 4U6EA 2BWSA 5FCHA 2NQ7A 2GG8A 2Q96A 2V3XA 2V3YA 1QXZA 1M35A 1R5HA 3MX6A 4HXXA 1W7VA 2BHBA 5CDVA 4PV4A 4IKSA 1KP0A 2BWTA 4U6WA 4IU6A 1JAWA 1MATA 4A6VA 2GG9A 4U71A 2GTXA 4JUQA 4FO8A 5CE6A 5JI6A 2Q8KA 4FLJA 1WN1A 4FLKA 1XNZA 2GA2A 1C23A 1A16A 3BIQA 2BH3A 2BWUA 1YJ3A 1XGNA 1B6AA 1C22A 3IU7A 4FO7A 1Y1NA 2EVOA 2B3LA 3RORA 3O5VA 2GGBA 2GU7A 2GU6A 5CIKA 2BHAA 4MATA 4OOKA 1WBQA 2B3HA 4IDYA 3IL0A 4U6ZA 1YW7A 3L7GA 1WLRA 4R60A 2ZSGA 3CB5A 1YW9A 3RVAA 3MATA 4FLLA 2Q92A 3MR1A 5JHUA 2P99A 3OVKA 2BWVA 4QR8A 2V3ZA 2GZ5A 2BWWA 4RZYA 1C21A 2EA2A 2HOWA 4U73A 1XGSA 2EA4A 2GU5A 3Q6DA 2IW2A 3PKCA 2NQ6A 5E2CA 5E5BA 3CTZA 3PKAA 4IF7A 4PNCA 2ADUA 3TAVA 1XGMA 4RGZ1 4ZWPA 3IU9A 4ZWUA 2GGCA 1YVMA 1QXWA 2BB7A 3L24A 1WL9A 4EGEA 3BITA 1BN5A 2BN7A 3CB6A 2OKNA 4FLIA 3FMRA 2Q93A 5CLSA 3BIPA 5CDEA 2V6CA 4IECA 4Z7MA 2GG0A 4IPAA 2B3KA 4KM3A 1XGOA 4A6WA 1KQ0A 2GG3A 4RZZA 5CDLA 3IG4A 4ZNGA 1BOAA 2EVCA 3IU8A 2GG7A 4U76A 4IKTA 2Q95A 5D6EA 4U75A 2P9AA 3TB5A 4B28A 4U1BA 2P98A 1R5GA 1KQ9A 2OAZA 3D27A 4IKRA 3QOCA 3FM3A 1QZYA 2GU4A 2BHDA 4S00A 2BHCA 1QXYA 1N51A 1WL6A 4S01A 2DFIA 3PEBA 2Q94A 2G6PA 3PN9A 3I7MA 4IKUA 4S2RP 1PV9A 1O0XA 3PKDA 4ZWOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BWY A;  4FKC A;  1WKM A;  5JFR A;  1R58 A;  3FMQ A;  4U6C A;  4U70 A;  5FCF A;  1B59 A;  1WY2 A;  1CHM A;  4U69 A;  2GG5 A;  5D6F A;  2BWX A;  4FUK A;  2EVM A;  1C27 A;  3PKB A;  1YW8 A;  4U6J A;  3S6B A;  3PKE A;  2MAT A;  1C24 A;  4S2T P;  3OOO A;  1W2M A;  5CNX A;  2GG2 A;  4U6E A;  2BWS A;  5FCH A;  2NQ7 A;  2GG8 A;  2Q96 A;  2V3X A;  2V3Y A;  1QXZ A;  1M35 A;  1R5H A;  3MX6 A;  4HXX A;  1W7V A;  2BHB A;  5CDV A;  4PV4 A;  4IKS A;  1KP0 A;  2BWT A;  4U6W A;  4IU6 A;  1JAW A;  1MAT A;  4A6V A;  2GG9 A;  4U71 A;  2GTX A;  4JUQ A;  4FO8 A;  5CE6 A;  5JI6 A;  2Q8K A;  4FLJ A;  1WN1 A;  4FLK A;  1XNZ A;  2GA2 A;  1C23 A;  1A16 A;  3BIQ A;  2BH3 A;  2BWU A;  1YJ3 A;  1XGN A;  1B6A A;  1C22 A;  3IU7 A;  4FO7 A;  1Y1N A;  2EVO A;  2B3L A;  3ROR A;  3O5V A;  2GGB A;  2GU7 A;  2GU6 A;  5CIK A;  2BHA A;  4MAT A;  4OOK A;  1WBQ A;  2B3H A;  4IDY A;  3IL0 A;  4U6Z A;  1YW7 A;  3L7G A;  1WLR A;  4R60 A;  2ZSG A;  3CB5 A;  1YW9 A;  3RVA A;  3MAT A;  4FLL A;  2Q92 A;  3MR1 A;  5JHU A;  2P99 A;  3OVK A;  2BWV A;  4QR8 A;  2V3Z A;  2GZ5 A;  2BWW A;  4RZY A;  1C21 A;  2EA2 A;  2HOW A;  4U73 A;  1XGS A;  2EA4 A;  2GU5 A;  3Q6D A;  2IW2 A;  3PKC A;  2NQ6 A;  5E2C A;  5E5B A;  3CTZ A;  3PKA A;  4IF7 A;  4PNC A;  2ADU A;  3TAV A;  1XGM A;  4RGZ 1;  4ZWP A;  3IU9 A;  4ZWU A;  2GGC A;  1YVM A;  1QXW A;  2BB7 A;  3L24 A;  1WL9 A;  4EGE A;  3BIT A;  1BN5 A;  2BN7 A;  3CB6 A;  2OKN A;  4FLI A;  3FMR A;  2Q93 A;  5CLS A;  3BIP A;  5CDE A;  2V6C A;  4IEC A;  4Z7M A;  2GG0 A;  4IPA A;  2B3K A;  4KM3 A;  1XGO A;  4A6W A;  1KQ0 A;  2GG3 A;  4RZZ A;  5CDL A;  3IG4 A;  4ZNG A;  1BOA A;  2EVC A;  3IU8 A;  2GG7 A;  4U76 A;  4IKT A;  2Q95 A;  5D6E A;  4U75 A;  2P9A A;  3TB5 A;  4B28 A;  4U1B A;  2P98 A;  1R5G A;  1KQ9 A;  2OAZ A;  3D27 A;  4IKR A;  3QOC A;  3FM3 A;  1QZY A;  2GU4 A;  2BHD A;  4S00 A;  2BHC A;  1QXY A;  1N51 A;  1WL6 A;  4S01 A;  2DFI A;  3PEB A;  2Q94 A;  2G6P A;  3PN9 A;  3I7M A;  4IKU A;  4S2R P;  1PV9 A;  1O0X A;  3PKD A;  4ZWO A; 
#chains in the Genus database with same CATH topology
 2BWY A;  4FKC A;  1WKM A;  5JFR A;  1R58 A;  3FMQ A;  4U6C A;  4U70 A;  5FCF A;  1B59 A;  1WY2 A;  1CHM A;  4U69 A;  2GG5 A;  5D6F A;  2BWX A;  4FUK A;  2EVM A;  1C27 A;  3PKB A;  1YW8 A;  4U6J A;  3S6B A;  3PKE A;  2MAT A;  1C24 A;  4S2T P;  3OOO A;  1W2M A;  5CNX A;  2GG2 A;  4U6E A;  2BWS A;  5FCH A;  2NQ7 A;  2GG8 A;  2Q96 A;  2V3X A;  2V3Y A;  1QXZ A;  1M35 A;  1R5H A;  3MX6 A;  4HXX A;  1W7V A;  2BHB A;  5CDV A;  4PV4 A;  4IKS A;  1KP0 A;  2BWT A;  4U6W A;  4IU6 A;  1JAW A;  1MAT A;  4A6V A;  2GG9 A;  4U71 A;  2GTX A;  4JUQ A;  4FO8 A;  5CE6 A;  5JI6 A;  2Q8K A;  4FLJ A;  1WN1 A;  4FLK A;  1XNZ A;  2GA2 A;  1C23 A;  1A16 A;  3BIQ A;  2BH3 A;  2BWU A;  1YJ3 A;  1XGN A;  1B6A A;  1C22 A;  3IU7 A;  4FO7 A;  1Y1N A;  2EVO A;  2B3L A;  3ROR A;  3O5V A;  2GGB A;  2GU7 A;  2GU6 A;  5CIK A;  2BHA A;  4MAT A;  4OOK A;  1WBQ A;  2B3H A;  4IDY A;  3IL0 A;  4U6Z A;  1YW7 A;  3L7G A;  1WLR A;  4R60 A;  2ZSG A;  3CB5 A;  1YW9 A;  3RVA A;  3MAT A;  4FLL A;  2Q92 A;  3MR1 A;  5JHU A;  2P99 A;  3OVK A;  2BWV A;  4QR8 A;  2V3Z A;  2GZ5 A;  2BWW A;  4RZY A;  1C21 A;  2EA2 A;  2HOW A;  4U73 A;  1XGS A;  2EA4 A;  2GU5 A;  3Q6D A;  2IW2 A;  3PKC A;  2NQ6 A;  5E2C A;  5E5B A;  3CTZ A;  3PKA A;  4IF7 A;  4PNC A;  2ADU A;  3TAV A;  1XGM A;  4RGZ 1;  4ZWP A;  3IU9 A;  4ZWU A;  2GGC A;  1YVM A;  1QXW A;  2BB7 A;  3L24 A;  1WL9 A;  4EGE A;  3BIT A;  1BN5 A;  2BN7 A;  3CB6 A;  2OKN A;  4FLI A;  3FMR A;  2Q93 A;  5CLS A;  3BIP A;  5CDE A;  2V6C A;  4IEC A;  4Z7M A;  2GG0 A;  4IPA A;  2B3K A;  4KM3 A;  1XGO A;  4A6W A;  1KQ0 A;  2GG3 A;  4RZZ A;  5CDL A;  3IG4 A;  4ZNG A;  1BOA A;  2EVC A;  3IU8 A;  2GG7 A;  4U76 A;  4IKT A;  2Q95 A;  5D6E A;  4U75 A;  2P9A A;  3TB5 A;  4B28 A;  4U1B A;  2P98 A;  1R5G A;  1KQ9 A;  2OAZ A;  3D27 A;  4IKR A;  3QOC A;  3FM3 A;  1QZY A;  2GU4 A;  2BHD A;  4S00 A;  2BHC A;  1QXY A;  1N51 A;  1WL6 A;  4S01 A;  2DFI A;  3PEB A;  2Q94 A;  2G6P A;  3PN9 A;  3I7M A;  4IKU A;  4S2R P;  1PV9 A;  1O0X A;  3PKD A;  4ZWO A; 
#chains in the Genus database with same CATH homology
 2BWY A;  4FKC A;  1WKM A;  5JFR A;  1R58 A;  3FMQ A;  4U6C A;  4U70 A;  5FCF A;  1B59 A;  1WY2 A;  1CHM A;  4U69 A;  2GG5 A;  5D6F A;  2BWX A;  4FUK A;  2EVM A;  1C27 A;  3PKB A;  1YW8 A;  4U6J A;  3S6B A;  3PKE A;  2MAT A;  1C24 A;  4S2T P;  3OOO A;  1W2M A;  5CNX A;  2GG2 A;  4U6E A;  2BWS A;  5FCH A;  2NQ7 A;  2GG8 A;  2Q96 A;  2V3X A;  2V3Y A;  1QXZ A;  1M35 A;  1R5H A;  3MX6 A;  4HXX A;  1W7V A;  2BHB A;  5CDV A;  4PV4 A;  4IKS A;  1KP0 A;  2BWT A;  4U6W A;  4IU6 A;  1JAW A;  1MAT A;  4A6V A;  2GG9 A;  4U71 A;  2GTX A;  4JUQ A;  4FO8 A;  5CE6 A;  5JI6 A;  2Q8K A;  4FLJ A;  1WN1 A;  4FLK A;  1XNZ A;  2GA2 A;  1C23 A;  1A16 A;  3BIQ A;  2BH3 A;  2BWU A;  1YJ3 A;  1XGN A;  1B6A A;  1C22 A;  3IU7 A;  4FO7 A;  1Y1N A;  2EVO A;  2B3L A;  3ROR A;  3O5V A;  2GGB A;  2GU7 A;  2GU6 A;  5CIK A;  2BHA A;  4MAT A;  4OOK A;  1WBQ A;  2B3H A;  4IDY A;  3IL0 A;  4U6Z A;  1YW7 A;  3L7G A;  1WLR A;  4R60 A;  2ZSG A;  3CB5 A;  1YW9 A;  3RVA A;  3MAT A;  4FLL A;  2Q92 A;  3MR1 A;  5JHU A;  2P99 A;  3OVK A;  2BWV A;  4QR8 A;  2V3Z A;  2GZ5 A;  2BWW A;  4RZY A;  1C21 A;  2EA2 A;  2HOW A;  4U73 A;  1XGS A;  2EA4 A;  2GU5 A;  3Q6D A;  2IW2 A;  3PKC A;  2NQ6 A;  5E2C A;  5E5B A;  3CTZ A;  3PKA A;  4IF7 A;  4PNC A;  2ADU A;  3TAV A;  1XGM A;  4RGZ 1;  4ZWP A;  3IU9 A;  4ZWU A;  2GGC A;  1YVM A;  1QXW A;  2BB7 A;  3L24 A;  1WL9 A;  4EGE A;  3BIT A;  1BN5 A;  2BN7 A;  3CB6 A;  2OKN A;  4FLI A;  3FMR A;  2Q93 A;  5CLS A;  3BIP A;  5CDE A;  2V6C A;  4IEC A;  4Z7M A;  2GG0 A;  4IPA A;  2B3K A;  4KM3 A;  1XGO A;  4A6W A;  1KQ0 A;  2GG3 A;  4RZZ A;  5CDL A;  3IG4 A;  4ZNG A;  1BOA A;  2EVC A;  3IU8 A;  2GG7 A;  4U76 A;  4IKT A;  2Q95 A;  5D6E A;  4U75 A;  2P9A A;  3TB5 A;  4B28 A;  4U1B A;  2P98 A;  1R5G A;  1KQ9 A;  2OAZ A;  3D27 A;  4IKR A;  3QOC A;  3FM3 A;  1QZY A;  2GU4 A;  2BHD A;  4S00 A;  2BHC A;  1QXY A;  1N51 A;  1WL6 A;  4S01 A;  2DFI A;  3PEB A;  2Q94 A;  2G6P A;  3PN9 A;  3I7M A;  4IKU A;  4S2R P;  1PV9 A;  1O0X A;  3PKD A;  4ZWO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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