4ZWUA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f, v342l, i215y
Total Genus 154
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
sequence length
439
structure length
435
Chain Sequence
NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNYVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQLHDVGGFMADEQGAHQEPGHPFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
molecule keywords ORGANOPHOSPHATE ANHYDROLASE/PROLIDASE
total genus 154
structure length 435
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwuA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwuA02
3CTZA 5CDLA 3OVKA 1Y1NA 2EVOA 3IL0A 2GG9A 1WN1A 2BWWA 4U70A 4U6JA 4A6VA 4FUKA 2GTXA 4EGEA 1WL9A 1YVMA 3L24A 2EA2A 5D6FA 4RGZ1 5E2CA 2P98A 5CDEA 3FMQA 5JFRA 2GU4A 3IU7A 4FLLA 3IG4A 2BWUA 4U6EA 2Q8KA 1C22A 4ZNGA 1W7VA 1QZYA 2GU7A 2GZ5A 2Q96A 3IU9A 5FCFA 1MATA 4IDYA 1WLRA 3PKEA 4IPAA 2Q95A 4U6ZA 2BWYA 3TB5A 1C21A 1O0XA 2OKNA 4S00A 1C24A 1R58A 1B59A 1WBQA 2GA2A 2V3YA 2Q92A 3D27A 2V3ZA 1YW7A 3MATA 3S6BA 3BITA 4IF7A 5E5BA 4U73A 3CB6A 1CHMA 4U76A 2EVMA 4QR8A 1QXWA 2HOWA 3CB5A 1QXYA 2NQ6A 5CE6A 4R60A 2BH3A 2DFIA 4MATA 4Z7MA 2GGBA 4FKCA 3PKDA 5JI6A 1BN5A 3PKCA 4ZWOA 2B3KA 2P9AA 2MATA 3L7GA 1KQ0A 2GG8A 2B3LA 4OOKA 2BHDA 1YW9A 1KQ9A 1YJ3A 1XGNA 2V3XA 4HXXA 1KP0A 2GG7A 2GU5A 1XGOA 4U6CA 1BOAA 2ZSGA 2P99A 4FLJA 1M35A 2BWVA 2ADUA 2B3HA 4KM3A 4U69A 4U75A 5CDVA 2GG0A 1XGMA 4FO8A 1WKMA 2Q93A 1WL6A 3BIPA 1R5HA 1XGSA 4RZZA 1A16A 4ZWUA 2Q94A 2BB7A 4PNCA 3PN9A 1JAWA 2BN7A 3PKBA 4B28A 4PV4A 4IU6A 4U1BA 5CLSA 4ZWPA 3OOOA 2NQ7A 3IU8A 4RZYA 4S2RP 3I7MA 4S01A 2OAZA 3BIQA 4IECA 2IW2A 4FLKA 4U71A 2BWSA 4IKSA 2BHBA 1XNZA 1B6AA 2GG2A 3RVAA 2GG3A 2EVCA 3RORA 4FLIA 1QXZA 5JHUA 3PEBA 3Q6DA 4FO7A 1C23A 2V6CA 4A6WA 5FCHA 1N51A 4IKRA 2BWXA 5CIKA 2GGCA 4IKTA 4IKUA 3TAVA 2BHAA 3PKAA 2G6PA 3O5VA 2EA4A 3MR1A 3FMRA 1R5GA 1PV9A 2GG5A 2BWTA 3MX6A 4S2TP 4JUQA 3FM3A 1C27A 1YW8A 4U6WA 2GU6A 2BHCA 1WY2A 5CNXA 1W2MA 3QOCA 5D6EA
chains in the Genus database with same CATH superfamily
3CTZA 5CDLA 3OVKA 1Y1NA 2EVOA 3IL0A 2GG9A 1WN1A 2BWWA 4U70A 4U6JA 4A6VA 4FUKA 2GTXA 4EGEA 1WL9A 1YVMA 3L24A 2EA2A 5D6FA 4RGZ1 5E2CA 2P98A 5CDEA 3FMQA 5JFRA 2GU4A 3IU7A 4FLLA 3IG4A 2BWUA 4U6EA 2Q8KA 1C22A 4ZNGA 1W7VA 1QZYA 2GU7A 2GZ5A 2Q96A 3IU9A 5FCFA 1MATA 4IDYA 1WLRA 3PKEA 4IPAA 2Q95A 4U6ZA 2BWYA 3TB5A 1C21A 1O0XA 2OKNA 4S00A 1C24A 1R58A 1B59A 1WBQA 2GA2A 2V3YA 2Q92A 3D27A 2V3ZA 1YW7A 3MATA 3S6BA 3BITA 4IF7A 5E5BA 4U73A 3CB6A 1CHMA 4U76A 2EVMA 4QR8A 1QXWA 2HOWA 3CB5A 1QXYA 2NQ6A 5CE6A 4R60A 2BH3A 2DFIA 4MATA 4Z7MA 2GGBA 4FKCA 3PKDA 5JI6A 1BN5A 3PKCA 4ZWOA 2B3KA 2P9AA 2MATA 3L7GA 1KQ0A 2GG8A 2B3LA 4OOKA 2BHDA 1YW9A 1KQ9A 1YJ3A 1XGNA 2V3XA 4HXXA 1KP0A 2GG7A 2GU5A 1XGOA 4U6CA 1BOAA 2ZSGA 2P99A 4FLJA 1M35A 2BWVA 2ADUA 2B3HA 4KM3A 4U69A 4U75A 5CDVA 2GG0A 1XGMA 4FO8A 1WKMA 2Q93A 1WL6A 3BIPA 1R5HA 1XGSA 4RZZA 1A16A 4ZWUA 2Q94A 2BB7A 4PNCA 3PN9A 1JAWA 2BN7A 3PKBA 4B28A 4PV4A 4IU6A 4U1BA 5CLSA 4ZWPA 3OOOA 2NQ7A 3IU8A 4RZYA 4S2RP 3I7MA 4S01A 2OAZA 3BIQA 4IECA 2IW2A 4FLKA 4U71A 2BWSA 4IKSA 2BHBA 1XNZA 1B6AA 2GG2A 3RVAA 2GG3A 2EVCA 3RORA 4FLIA 1QXZA 5JHUA 3PEBA 3Q6DA 4FO7A 1C23A 2V6CA 4A6WA 5FCHA 1N51A 4IKRA 2BWXA 5CIKA 2GGCA 4IKTA 4IKUA 3TAVA 2BHAA 3PKAA 2G6PA 3O5VA 2EA4A 3MR1A 3FMRA 1R5GA 1PV9A 2GG5A 2BWTA 3MX6A 4S2TP 4JUQA 3FM3A 1C27A 1YW8A 4U6WA 2GU6A 2BHCA 1WY2A 5CNXA 1W2MA 3QOCA 5D6EA
chains in the Genus database with same CATH topology
3CTZA 5CDLA 3OVKA 1Y1NA 2EVOA 3IL0A 2GG9A 1WN1A 2BWWA 4U70A 4U6JA 4A6VA 4FUKA 2GTXA 4EGEA 1WL9A 1YVMA 3L24A 2EA2A 5D6FA 4RGZ1 5E2CA 2P98A 5CDEA 3FMQA 5JFRA 2GU4A 3IU7A 4FLLA 3IG4A 2BWUA 4U6EA 2Q8KA 1C22A 4ZNGA 1W7VA 1QZYA 2GU7A 2GZ5A 2Q96A 3IU9A 5FCFA 1MATA 4IDYA 1WLRA 3PKEA 4IPAA 2Q95A 4U6ZA 2BWYA 3TB5A 1C21A 1O0XA 2OKNA 4S00A 1C24A 1R58A 1B59A 1WBQA 2GA2A 2V3YA 2Q92A 3D27A 2V3ZA 1YW7A 3MATA 3S6BA 3BITA 4IF7A 5E5BA 4U73A 3CB6A 1CHMA 4U76A 2EVMA 4QR8A 1QXWA 2HOWA 3CB5A 1QXYA 2NQ6A 5CE6A 4R60A 2BH3A 2DFIA 4MATA 4Z7MA 2GGBA 4FKCA 3PKDA 5JI6A 1BN5A 3PKCA 4ZWOA 2B3KA 2P9AA 2MATA 3L7GA 1KQ0A 2GG8A 2B3LA 4OOKA 2BHDA 1YW9A 1KQ9A 1YJ3A 1XGNA 2V3XA 4HXXA 1KP0A 2GG7A 2GU5A 1XGOA 4U6CA 1BOAA 2ZSGA 2P99A 4FLJA 1M35A 2BWVA 2ADUA 2B3HA 4KM3A 4U69A 4U75A 5CDVA 2GG0A 1XGMA 4FO8A 1WKMA 2Q93A 1WL6A 3BIPA 1R5HA 1XGSA 4RZZA 1A16A 4ZWUA 2Q94A 2BB7A 4PNCA 3PN9A 1JAWA 2BN7A 3PKBA 4B28A 4PV4A 4IU6A 4U1BA 5CLSA 4ZWPA 3OOOA 2NQ7A 3IU8A 4RZYA 4S2RP 3I7MA 4S01A 2OAZA 3BIQA 4IECA 2IW2A 4FLKA 4U71A 2BWSA 4IKSA 2BHBA 1XNZA 1B6AA 2GG2A 3RVAA 2GG3A 2EVCA 3RORA 4FLIA 1QXZA 5JHUA 3PEBA 3Q6DA 4FO7A 1C23A 2V6CA 4A6WA 5FCHA 1N51A 4IKRA 2BWXA 5CIKA 2GGCA 4IKTA 4IKUA 3TAVA 2BHAA 3PKAA 2G6PA 3O5VA 2EA4A 3MR1A 3FMRA 1R5GA 1PV9A 2GG5A 2BWTA 3MX6A 4S2TP 4JUQA 3FM3A 1C27A 1YW8A 4U6WA 2GU6A 2BHCA 1WY2A 5CNXA 1W2MA 3QOCA 5D6EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CTZ A;  5CDL A;  3OVK A;  1Y1N A;  2EVO A;  3IL0 A;  2GG9 A;  1WN1 A;  2BWW A;  4U70 A;  4U6J A;  4A6V A;  4FUK A;  2GTX A;  4EGE A;  1WL9 A;  1YVM A;  3L24 A;  2EA2 A;  5D6F A;  4RGZ 1;  5E2C A;  2P98 A;  5CDE A;  3FMQ A;  5JFR A;  2GU4 A;  3IU7 A;  4FLL A;  3IG4 A;  2BWU A;  4U6E A;  2Q8K A;  1C22 A;  4ZNG A;  1W7V A;  1QZY A;  2GU7 A;  2GZ5 A;  2Q96 A;  3IU9 A;  5FCF A;  1MAT A;  4IDY A;  1WLR A;  3PKE A;  4IPA A;  2Q95 A;  4U6Z A;  2BWY A;  3TB5 A;  1C21 A;  1O0X A;  2OKN A;  4S00 A;  1C24 A;  1R58 A;  1B59 A;  1WBQ A;  2GA2 A;  2V3Y A;  2Q92 A;  3D27 A;  2V3Z A;  1YW7 A;  3MAT A;  3S6B A;  3BIT A;  4IF7 A;  5E5B A;  4U73 A;  3CB6 A;  1CHM A;  4U76 A;  2EVM A;  4QR8 A;  1QXW A;  2HOW A;  3CB5 A;  1QXY A;  2NQ6 A;  5CE6 A;  4R60 A;  2BH3 A;  2DFI A;  4MAT A;  4Z7M A;  2GGB A;  4FKC A;  3PKD A;  5JI6 A;  1BN5 A;  3PKC A;  4ZWO A;  2B3K A;  2P9A A;  2MAT A;  3L7G A;  1KQ0 A;  2GG8 A;  2B3L A;  4OOK A;  2BHD A;  1YW9 A;  1KQ9 A;  1YJ3 A;  1XGN A;  2V3X A;  4HXX A;  1KP0 A;  2GG7 A;  2GU5 A;  1XGO A;  4U6C A;  1BOA A;  2ZSG A;  2P99 A;  4FLJ A;  1M35 A;  2BWV A;  2ADU A;  2B3H A;  4KM3 A;  4U69 A;  4U75 A;  5CDV A;  2GG0 A;  1XGM A;  4FO8 A;  1WKM A;  2Q93 A;  1WL6 A;  3BIP A;  1R5H A;  1XGS A;  4RZZ A;  1A16 A;  4ZWU A;  2Q94 A;  2BB7 A;  4PNC A;  3PN9 A;  1JAW A;  2BN7 A;  3PKB A;  4B28 A;  4PV4 A;  4IU6 A;  4U1B A;  5CLS A;  4ZWP A;  3OOO A;  2NQ7 A;  3IU8 A;  4RZY A;  4S2R P;  3I7M A;  4S01 A;  2OAZ A;  3BIQ A;  4IEC A;  2IW2 A;  4FLK A;  4U71 A;  2BWS A;  4IKS A;  2BHB A;  1XNZ A;  1B6A A;  2GG2 A;  3RVA A;  2GG3 A;  2EVC A;  3ROR A;  4FLI A;  1QXZ A;  5JHU A;  3PEB A;  3Q6D A;  4FO7 A;  1C23 A;  2V6C A;  4A6W A;  5FCH A;  1N51 A;  4IKR A;  2BWX A;  5CIK A;  2GGC A;  4IKT A;  4IKU A;  3TAV A;  2BHA A;  3PKA A;  2G6P A;  3O5V A;  2EA4 A;  3MR1 A;  3FMR A;  1R5G A;  1PV9 A;  2GG5 A;  2BWT A;  3MX6 A;  4S2T P;  4JUQ A;  3FM3 A;  1C27 A;  1YW8 A;  4U6W A;  2GU6 A;  2BHC A;  1WY2 A;  5CNX A;  1W2M A;  3QOC A;  5D6E A; 
#chains in the Genus database with same CATH topology
 3CTZ A;  5CDL A;  3OVK A;  1Y1N A;  2EVO A;  3IL0 A;  2GG9 A;  1WN1 A;  2BWW A;  4U70 A;  4U6J A;  4A6V A;  4FUK A;  2GTX A;  4EGE A;  1WL9 A;  1YVM A;  3L24 A;  2EA2 A;  5D6F A;  4RGZ 1;  5E2C A;  2P98 A;  5CDE A;  3FMQ A;  5JFR A;  2GU4 A;  3IU7 A;  4FLL A;  3IG4 A;  2BWU A;  4U6E A;  2Q8K A;  1C22 A;  4ZNG A;  1W7V A;  1QZY A;  2GU7 A;  2GZ5 A;  2Q96 A;  3IU9 A;  5FCF A;  1MAT A;  4IDY A;  1WLR A;  3PKE A;  4IPA A;  2Q95 A;  4U6Z A;  2BWY A;  3TB5 A;  1C21 A;  1O0X A;  2OKN A;  4S00 A;  1C24 A;  1R58 A;  1B59 A;  1WBQ A;  2GA2 A;  2V3Y A;  2Q92 A;  3D27 A;  2V3Z A;  1YW7 A;  3MAT A;  3S6B A;  3BIT A;  4IF7 A;  5E5B A;  4U73 A;  3CB6 A;  1CHM A;  4U76 A;  2EVM A;  4QR8 A;  1QXW A;  2HOW A;  3CB5 A;  1QXY A;  2NQ6 A;  5CE6 A;  4R60 A;  2BH3 A;  2DFI A;  4MAT A;  4Z7M A;  2GGB A;  4FKC A;  3PKD A;  5JI6 A;  1BN5 A;  3PKC A;  4ZWO A;  2B3K A;  2P9A A;  2MAT A;  3L7G A;  1KQ0 A;  2GG8 A;  2B3L A;  4OOK A;  2BHD A;  1YW9 A;  1KQ9 A;  1YJ3 A;  1XGN A;  2V3X A;  4HXX A;  1KP0 A;  2GG7 A;  2GU5 A;  1XGO A;  4U6C A;  1BOA A;  2ZSG A;  2P99 A;  4FLJ A;  1M35 A;  2BWV A;  2ADU A;  2B3H A;  4KM3 A;  4U69 A;  4U75 A;  5CDV A;  2GG0 A;  1XGM A;  4FO8 A;  1WKM A;  2Q93 A;  1WL6 A;  3BIP A;  1R5H A;  1XGS A;  4RZZ A;  1A16 A;  4ZWU A;  2Q94 A;  2BB7 A;  4PNC A;  3PN9 A;  1JAW A;  2BN7 A;  3PKB A;  4B28 A;  4PV4 A;  4IU6 A;  4U1B A;  5CLS A;  4ZWP A;  3OOO A;  2NQ7 A;  3IU8 A;  4RZY A;  4S2R P;  3I7M A;  4S01 A;  2OAZ A;  3BIQ A;  4IEC A;  2IW2 A;  4FLK A;  4U71 A;  2BWS A;  4IKS A;  2BHB A;  1XNZ A;  1B6A A;  2GG2 A;  3RVA A;  2GG3 A;  2EVC A;  3ROR A;  4FLI A;  1QXZ A;  5JHU A;  3PEB A;  3Q6D A;  4FO7 A;  1C23 A;  2V6C A;  4A6W A;  5FCH A;  1N51 A;  4IKR A;  2BWX A;  5CIK A;  2GGC A;  4IKT A;  4IKU A;  3TAV A;  2BHA A;  3PKA A;  2G6P A;  3O5V A;  2EA4 A;  3MR1 A;  3FMR A;  1R5G A;  1PV9 A;  2GG5 A;  2BWT A;  3MX6 A;  4S2T P;  4JUQ A;  3FM3 A;  1C27 A;  1YW8 A;  4U6W A;  2GU6 A;  2BHC A;  1WY2 A;  5CNX A;  1W2M A;  3QOC A;  5D6E A; 
#chains in the Genus database with same CATH homology
 3CTZ A;  5CDL A;  3OVK A;  1Y1N A;  2EVO A;  3IL0 A;  2GG9 A;  1WN1 A;  2BWW A;  4U70 A;  4U6J A;  4A6V A;  4FUK A;  2GTX A;  4EGE A;  1WL9 A;  1YVM A;  3L24 A;  2EA2 A;  5D6F A;  4RGZ 1;  5E2C A;  2P98 A;  5CDE A;  3FMQ A;  5JFR A;  2GU4 A;  3IU7 A;  4FLL A;  3IG4 A;  2BWU A;  4U6E A;  2Q8K A;  1C22 A;  4ZNG A;  1W7V A;  1QZY A;  2GU7 A;  2GZ5 A;  2Q96 A;  3IU9 A;  5FCF A;  1MAT A;  4IDY A;  1WLR A;  3PKE A;  4IPA A;  2Q95 A;  4U6Z A;  2BWY A;  3TB5 A;  1C21 A;  1O0X A;  2OKN A;  4S00 A;  1C24 A;  1R58 A;  1B59 A;  1WBQ A;  2GA2 A;  2V3Y A;  2Q92 A;  3D27 A;  2V3Z A;  1YW7 A;  3MAT A;  3S6B A;  3BIT A;  4IF7 A;  5E5B A;  4U73 A;  3CB6 A;  1CHM A;  4U76 A;  2EVM A;  4QR8 A;  1QXW A;  2HOW A;  3CB5 A;  1QXY A;  2NQ6 A;  5CE6 A;  4R60 A;  2BH3 A;  2DFI A;  4MAT A;  4Z7M A;  2GGB A;  4FKC A;  3PKD A;  5JI6 A;  1BN5 A;  3PKC A;  4ZWO A;  2B3K A;  2P9A A;  2MAT A;  3L7G A;  1KQ0 A;  2GG8 A;  2B3L A;  4OOK A;  2BHD A;  1YW9 A;  1KQ9 A;  1YJ3 A;  1XGN A;  2V3X A;  4HXX A;  1KP0 A;  2GG7 A;  2GU5 A;  1XGO A;  4U6C A;  1BOA A;  2ZSG A;  2P99 A;  4FLJ A;  1M35 A;  2BWV A;  2ADU A;  2B3H A;  4KM3 A;  4U69 A;  4U75 A;  5CDV A;  2GG0 A;  1XGM A;  4FO8 A;  1WKM A;  2Q93 A;  1WL6 A;  3BIP A;  1R5H A;  1XGS A;  4RZZ A;  1A16 A;  4ZWU A;  2Q94 A;  2BB7 A;  4PNC A;  3PN9 A;  1JAW A;  2BN7 A;  3PKB A;  4B28 A;  4PV4 A;  4IU6 A;  4U1B A;  5CLS A;  4ZWP A;  3OOO A;  2NQ7 A;  3IU8 A;  4RZY A;  4S2R P;  3I7M A;  4S01 A;  2OAZ A;  3BIQ A;  4IEC A;  2IW2 A;  4FLK A;  4U71 A;  2BWS A;  4IKS A;  2BHB A;  1XNZ A;  1B6A A;  2GG2 A;  3RVA A;  2GG3 A;  2EVC A;  3ROR A;  4FLI A;  1QXZ A;  5JHU A;  3PEB A;  3Q6D A;  4FO7 A;  1C23 A;  2V6C A;  4A6W A;  5FCH A;  1N51 A;  4IKR A;  2BWX A;  5CIK A;  2GGC A;  4IKT A;  4IKU A;  3TAV A;  2BHA A;  3PKA A;  2G6P A;  3O5V A;  2EA4 A;  3MR1 A;  3FMR A;  1R5G A;  1PV9 A;  2GG5 A;  2BWT A;  3MX6 A;  4S2T P;  4JUQ A;  3FM3 A;  1C27 A;  1YW8 A;  4U6W A;  2GU6 A;  2BHC A;  1WY2 A;  5CNX A;  1W2M A;  3QOC A;  5D6E A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...