3V66A

Human squalene synthase in complex with 2-(1-{2-[(4r,6s)-8-chloro-6-(2,3-dimethoxyphenyl)-4h,6h-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid
Total Genus 142
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
142
sequence length
335
structure length
335
Chain Sequence
LSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of novel tricyclic compounds as squalene synthase inhibitors
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Squalene synthase
total genus 142
structure length 335
sequence length 335
ec nomenclature ec 2.5.1.21: Squalene synthase.
pdb deposition date 2011-12-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00494 SQS_PSY Squalene/phytoene synthase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 3v66A00
5JUZF 4JZBA 5DHIA 3DYFA 5IN8A 4LZCA 4LFGA 4GP1A 4LXWA 1EZFA 5DJVF 1HM4A 3WEFA 4FP4A 1RQJA 4RXCA 3CP6A 5IMPA 2F8CF 1V4HA 5DJPF 4KUXA 3LOMA 3OACA 3LGZB 3WCGA 5ILZA 4KFAA 4P0WA 4F62A 1YHKA 3PYAA 2QISA 4KKMA 5E8HA 2ZCRA 3PKOA 3BNXA 5IK9A 3AE0A 1JFGA 1N1ZA 3LJIA 3CKEA 3M9UA 2EWGA 2Z4VA 3M0GA 1VG6A 2PS4A 3WE9A 4KPJA 4PVYF 5DIQF 1VG7A 3ID0A 5B0IA 5ILIA 2E8TA 4N9UA 1N22A 2Z4XA 1VG2A 4KVWA 3MAVA 2OPMA 3WEGA 3WCLA 4NFIF 1FPSA 4QXSF 4NFJF 1HM7A 3VJAA 5ILYA 3EFQA 3KBKA 1ZW5A 2PS5A 2Z78A 5HNAA 2VF6A 2E8WA 3LEEA 4XQSF 3KRFA 4OMHA 1YYRA 3KRPA 4KVIA 2OPNA 5EAUA 3V1VA 2Z4YA 4DHDA 4P0VA 3Q30A 3ICNA 3RYEA 3ICKA 2E92A 2J1PA 3WC9A 3SDTA 3MZVA 2F94F 3P5PA 5HN8A 5IVGA 5IKAA 3KB9A 4LLTA 3RMGA 5IL8A 4N1ZF 4WK5A 3NPKA 3P41A 3V1XA 5B01A 4RXDA 4F6VA 4JVJF 5A0JA 1V4IA 5EASA 1N20A 3WJOA 5ILHA 2ZY1A 4LA5A 3N49F 3N0FA 3M00A 5B02A 3KROA 1N21A 5IM1A 3B7LA 3CC9A 5JV2F 1WY0A 3TS7A 5IK6A 3N5HF 4HD1A 5CG5A 2PS8A 3AQ0A 3LVSA 5H9DA 3P8LA 5JV0F 2F8ZF 4NFKF 5AFXA 1UBWA 5ERNA 3RBMA 1WL0A 5AHUB 5IL3A 1N24A 1HXAA 3N6KF 4KWDA 3N1WF 5EATA 3P8RA 5ILKA 2F9KF 4PVXF 5DGMF 2I19A 3QKCA 4H5DF 1YJ4A 3KRAA 3VJ8A 1YYUA 4EA2A 5IKHA 3WCMA 3PH7A 1RTRA 3ACWA 4LUUA 3LG5A 5B0LA 3SDVA 2E4OA 1WL2A 3SDUA 1PS1A 2AELA 2PS7A 4GP2A 3WEKA 3WCCA 2E8XA 4EA1A 2F7MF 5AELA 4QPFA 3OABB 5ER8A 4LA6A 2ZEUA 4E9UA 3M02A 3LK5A 3WSBA 2ONGA 2F92F 5E8KA 4OGUA 3ZMCA 2Z4ZA 3N45F 1VG3A 3LGKA 3WCFA 4LZ3A 3ADZA 5ERMA 3BNYA 2P1CA 4OKZA 4K10A 4KVDA 5B00A 4NKEA 1YYQA 3LLWA 3WEIA 1HXCA 3NF2A 3WEHA 4JYXA 3P5RA 3TFPA 4LPHF 3APZA 3NPRA 3IBAA 4EA0A 3WCJA 5C05A 2Q9ZA 4KK2A 3WSAA 4XQTF 3WCAA 2E93A 2E95A 2E8VA 5DW7A 3UCAA 4LPGF 3Q1OA 4ZQ8A 4RYPA 3ICMA 3VJEA 3WCHA 3EGTA 4MC8A 4GA3A 4MC0A 4DEMF 3OYRA 2Q80A 2Z7IA 4H5CF 5HN9A 4NUAA 5DZ2A 1VG4A 4KPDA 2AEKA 1V4KA 3TFVA 3S4JA 3SDRA 1KIYA 3W7FA 3SDQA 4RNQA 5AYPA 5A0IA 1WL3A 1YQ7A 5ILDA 3G4DA 1WKZA 1N23A 1YYTA 3N3LF 1YV5A 3N5JF 5B0KA 4KVYA 1DI1A 4DWBA 5HN7A 2Q9YA 4DI5A 2DH4A 3TC1A 3WCIA 3ACYA 1KIZA 3IPIA 3Q2QA 2OA6A 2ONHA 1UBYA 1YYSA 3DYGA 3TFNA 3LSNA 3WJKA 3SAEA 3QQVA 3LDWA 3PDEA 2FORA 1N1BA 3WCBA 2Z4WA 4FJQA 2J5CA 2AZLA 3PYBA 3N0GA 2AZKA 5EROA 3VJBA 2ZCQA 1HXGA 3ZCDA 1UBVA 4LTVA 2ZEVA 4LFVF 4LTZA 5B03A 3ZL6A 4KQUA 3KRFB 5B0MA 1YHLA 4L2XF 2J1OA 5CG6A 5KSXF 1JFAA 4E9ZA 4NG6A 5IMNA 2H8OA 3N1VF 4H5EF 3KRPB 2OGDA 2ZCSA 4RXEA 2E8UA 2E90A 4DWGA 5B0JA 5IK0A 5IMIA 3S9VA 4NKFA 1V4JA 3KRCB 3OABA 5JA0F 1RQIA 3ZOUA 3M01A 1WL1A 2AETA 2Z50A 3AQCB 2E91A 2ZCOA 5JV1F 2RAHA 4DXJA 1DGPA 4Q23A 4XQRF 4LFEA 2O1OA 5DGSF 4MC3A 1UBXA 4OMGA 4LIXA 3NRIA 4UMJA 4KQ5A 3WCEA 3G4FA 3Q2ZA 3N46F 4E1EA 5ILJA 2Z52A 3KROB 3VJDA 1WMWA 4LZ0A 3KRCA 4LOBA 1V4EA 3DYHA 5DJRF 3ZMBA 4OKMA 3AQBB 3RYWA 5I1UA 3V66A 3ASXA 2Q58A 2E94A 4KQSA 4P0XA 3ACXA 4DZWA 5DHKA 5E8LA 2Z7HA 3VJ9A 2AZJA 1YHMA 5DGNF 2F89F 3WCDA 3VJCA 5A0KA 4JXYA 4JXNA 3WJNA 3EZ3A 2PS6A 4F6XA 3LZ9A 4RXAA 3LMDA 3OACB 3ICZA 3N3DA 2FTZA 4LLSA 4GAXA 1HX9A 3KRAB 4JZXA 3WEJA
chains in the Genus database with same CATH superfamily
5JUZF 4JZBA 5DHIA 3DYFA 5IN8A 4LZCA 4LFGA 4GP1A 4LXWA 1EZFA 5DJVF 1HM4A 3WEFA 4FP4A 1RQJA 4RXCA 3CP6A 5IMPA 2F8CF 1V4HA 5DJPF 4KUXA 3LOMA 3OACA 3LGZB 3WCGA 5ILZA 4KFAA 4P0WA 4F62A 1YHKA 3PYAA 2QISA 4KKMA 5E8HA 2ZCRA 3PKOA 3BNXA 5IK9A 3AE0A 1JFGA 1N1ZA 3LJIA 3CKEA 3M9UA 2EWGA 2Z4VA 3M0GA 1VG6A 2PS4A 3WE9A 4KPJA 4PVYF 5DIQF 1VG7A 3ID0A 5B0IA 5ILIA 2E8TA 4N9UA 1N22A 2Z4XA 1VG2A 4KVWA 3MAVA 2OPMA 3WEGA 3WCLA 4NFIF 1FPSA 4QXSF 4NFJF 1HM7A 3VJAA 5ILYA 3EFQA 3KBKA 1ZW5A 2PS5A 2Z78A 5HNAA 2VF6A 2E8WA 3LEEA 4XQSF 3KRFA 4OMHA 1YYRA 3KRPA 4KVIA 2OPNA 5EAUA 3V1VA 2Z4YA 4DHDA 4P0VA 3Q30A 3ICNA 3RYEA 3ICKA 2E92A 2J1PA 3WC9A 3SDTA 3MZVA 2F94F 3P5PA 5HN8A 5IVGA 5IKAA 3KB9A 4LLTA 3RMGA 5IL8A 4N1ZF 4WK5A 3NPKA 3P41A 3V1XA 5B01A 4RXDA 4F6VA 4JVJF 5A0JA 1V4IA 5EASA 1N20A 3WJOA 5ILHA 2ZY1A 4LA5A 3N49F 3N0FA 3M00A 5B02A 3KROA 1N21A 5IM1A 3B7LA 3CC9A 5JV2F 1WY0A 3TS7A 5IK6A 3N5HF 4HD1A 5CG5A 2PS8A 3AQ0A 3LVSA 5H9DA 3P8LA 5JV0F 2F8ZF 4NFKF 5AFXA 1UBWA 5ERNA 3RBMA 1WL0A 5AHUB 5IL3A 1N24A 1HXAA 3N6KF 4KWDA 3N1WF 5EATA 3P8RA 5ILKA 2F9KF 4PVXF 5DGMF 2I19A 3QKCA 4H5DF 1YJ4A 3KRAA 3VJ8A 1YYUA 4EA2A 5IKHA 3WCMA 3PH7A 1RTRA 3ACWA 4LUUA 3LG5A 5B0LA 3SDVA 2E4OA 1WL2A 3SDUA 1PS1A 2AELA 2PS7A 4GP2A 3WEKA 3WCCA 2E8XA 4EA1A 2F7MF 5AELA 4QPFA 3OABB 5ER8A 4LA6A 2ZEUA 4E9UA 3M02A 3LK5A 3WSBA 2ONGA 2F92F 5E8KA 4OGUA 3ZMCA 2Z4ZA 3N45F 1VG3A 3LGKA 3WCFA 4LZ3A 3ADZA 5ERMA 3BNYA 2P1CA 4OKZA 4K10A 4KVDA 5B00A 4NKEA 1YYQA 3LLWA 3WEIA 1HXCA 3NF2A 3WEHA 4JYXA 3P5RA 3TFPA 4LPHF 3APZA 3NPRA 3IBAA 4EA0A 3WCJA 5C05A 2Q9ZA 4KK2A 3WSAA 4XQTF 3WCAA 2E93A 2E95A 2E8VA 5DW7A 3UCAA 4LPGF 3Q1OA 4ZQ8A 4RYPA 3ICMA 3VJEA 3WCHA 3EGTA 4MC8A 4GA3A 4MC0A 4DEMF 3OYRA 2Q80A 2Z7IA 4H5CF 5HN9A 4NUAA 5DZ2A 1VG4A 4KPDA 2AEKA 1V4KA 3TFVA 3S4JA 3SDRA 1KIYA 3W7FA 3SDQA 4RNQA 5AYPA 5A0IA 1WL3A 1YQ7A 5ILDA 3G4DA 1WKZA 1N23A 1YYTA 3N3LF 1YV5A 3N5JF 5B0KA 4KVYA 1DI1A 4DWBA 5HN7A 2Q9YA 4DI5A 2DH4A 3TC1A 3WCIA 3ACYA 1KIZA 3IPIA 3Q2QA 2OA6A 2ONHA 1UBYA 1YYSA 3DYGA 3TFNA 3LSNA 3WJKA 3SAEA 3QQVA 3LDWA 3PDEA 2FORA 1N1BA 3WCBA 2Z4WA 4FJQA 2J5CA 2AZLA 3PYBA 3N0GA 2AZKA 5EROA 3VJBA 2ZCQA 1HXGA 3ZCDA 1UBVA 4LTVA 2ZEVA 4LFVF 4LTZA 5B03A 3ZL6A 4KQUA 3KRFB 5B0MA 1YHLA 4L2XF 2J1OA 5CG6A 5KSXF 1JFAA 4E9ZA 4NG6A 5IMNA 2H8OA 3N1VF 4H5EF 3KRPB 2OGDA 2ZCSA 4RXEA 2E8UA 2E90A 4DWGA 5B0JA 5IK0A 5IMIA 3S9VA 4NKFA 1V4JA 3KRCB 3OABA 5JA0F 1RQIA 3ZOUA 3M01A 1WL1A 2AETA 2Z50A 3AQCB 2E91A 2ZCOA 5JV1F 2RAHA 4DXJA 1DGPA 4Q23A 4XQRF 4LFEA 2O1OA 5DGSF 4MC3A 1UBXA 4OMGA 4LIXA 3NRIA 4UMJA 4KQ5A 3WCEA 3G4FA 3Q2ZA 3N46F 4E1EA 5ILJA 2Z52A 3KROB 3VJDA 1WMWA 4LZ0A 3KRCA 4LOBA 1V4EA 3DYHA 5DJRF 3ZMBA 4OKMA 3AQBB 3RYWA 5I1UA 3V66A 3ASXA 2Q58A 2E94A 4KQSA 4P0XA 3ACXA 4DZWA 5DHKA 5E8LA 2Z7HA 3VJ9A 2AZJA 1YHMA 5DGNF 2F89F 3WCDA 3VJCA 5A0KA 4JXYA 4JXNA 3WJNA 3EZ3A 2PS6A 4F6XA 3LZ9A 4RXAA 3LMDA 3OACB 3ICZA 3N3DA 2FTZA 4LLSA 4GAXA 1HX9A 3KRAB 4JZXA 3WEJA
chains in the Genus database with same CATH topology
5JUZF 4JZBA 5DHIA 3DYFA 5IN8A 4LZCA 4LFGA 4GP1A 4LXWA 1EZFA 5DJVF 1HM4A 3WEFA 4FP4A 1RQJA 4RXCA 3CP6A 5IMPA 2F8CF 1V4HA 5DJPF 4KUXA 3LOMA 3OACA 3LGZB 3WCGA 5ILZA 4KFAA 4P0WA 4F62A 1YHKA 3PYAA 2QISA 4KKMA 5E8HA 2ZCRA 3PKOA 3BNXA 5IK9A 3AE0A 1JFGA 1N1ZA 3LJIA 3CKEA 3M9UA 2EWGA 2Z4VA 3M0GA 1VG6A 2PS4A 3WE9A 4KPJA 4PVYF 5DIQF 1VG7A 3ID0A 5B0IA 5ILIA 2E8TA 4N9UA 1N22A 2Z4XA 1VG2A 4KVWA 3MAVA 2OPMA 3WEGA 3WCLA 4NFIF 1FPSA 4QXSF 4NFJF 1HM7A 3VJAA 5ILYA 3EFQA 3KBKA 1ZW5A 2PS5A 2Z78A 5HNAA 2VF6A 2E8WA 3LEEA 4XQSF 3KRFA 4OMHA 1YYRA 3KRPA 4KVIA 2OPNA 5EAUA 3V1VA 2Z4YA 4DHDA 4P0VA 3Q30A 3ICNA 3RYEA 3ICKA 2E92A 2J1PA 3WC9A 3SDTA 3MZVA 2F94F 3P5PA 5HN8A 5IVGA 5IKAA 3KB9A 4LLTA 3RMGA 5IL8A 4N1ZF 4WK5A 3NPKA 3P41A 3V1XA 5B01A 4RXDA 4F6VA 4JVJF 5A0JA 1V4IA 5EASA 1N20A 3WJOA 5ILHA 2ZY1A 4LA5A 3N49F 3N0FA 3M00A 5B02A 3KROA 1N21A 5IM1A 3B7LA 3CC9A 5JV2F 1WY0A 3TS7A 5IK6A 3N5HF 4HD1A 5CG5A 2PS8A 3AQ0A 3LVSA 5H9DA 3P8LA 5JV0F 2F8ZF 4NFKF 5AFXA 1UBWA 5ERNA 3RBMA 1WL0A 5AHUB 5IL3A 1N24A 1HXAA 3N6KF 4KWDA 3N1WF 5EATA 3P8RA 5ILKA 2F9KF 4PVXF 5DGMF 2I19A 3QKCA 4H5DF 1YJ4A 3KRAA 3VJ8A 1YYUA 4EA2A 5IKHA 3WCMA 3PH7A 1RTRA 3ACWA 4LUUA 3LG5A 5B0LA 3SDVA 2E4OA 1WL2A 3SDUA 1PS1A 2AELA 2PS7A 4GP2A 3WEKA 3WCCA 2E8XA 4EA1A 2F7MF 5AELA 4QPFA 3OABB 5ER8A 4LA6A 2ZEUA 4E9UA 3M02A 3LK5A 3WSBA 2ONGA 2F92F 5E8KA 4OGUA 3ZMCA 2Z4ZA 3N45F 1VG3A 3LGKA 3WCFA 4LZ3A 3ADZA 5ERMA 3BNYA 2P1CA 4OKZA 4K10A 4KVDA 5B00A 4NKEA 1YYQA 3LLWA 3WEIA 1HXCA 3NF2A 3WEHA 4JYXA 3P5RA 3TFPA 4LPHF 3APZA 3NPRA 3IBAA 4EA0A 3WCJA 5C05A 2Q9ZA 4KK2A 3WSAA 4XQTF 3WCAA 2E93A 2E95A 2E8VA 5DW7A 3UCAA 4LPGF 3Q1OA 4ZQ8A 4RYPA 3ICMA 3VJEA 3WCHA 3EGTA 4MC8A 4GA3A 4MC0A 4DEMF 3OYRA 2Q80A 2Z7IA 4H5CF 5HN9A 4NUAA 5DZ2A 1VG4A 4KPDA 2AEKA 1V4KA 3TFVA 3S4JA 3SDRA 1KIYA 3W7FA 3SDQA 4RNQA 5AYPA 5A0IA 1WL3A 1YQ7A 5ILDA 3G4DA 1WKZA 1N23A 1YYTA 3N3LF 1YV5A 3N5JF 5B0KA 4KVYA 1DI1A 4DWBA 5HN7A 2Q9YA 4DI5A 2DH4A 3TC1A 3WCIA 3ACYA 1KIZA 3IPIA 3Q2QA 2OA6A 2ONHA 1UBYA 1YYSA 3DYGA 3TFNA 3LSNA 3WJKA 3SAEA 3QQVA 3LDWA 3PDEA 2FORA 1N1BA 3WCBA 2Z4WA 4FJQA 2J5CA 2AZLA 3PYBA 3N0GA 2AZKA 5EROA 3VJBA 2ZCQA 1HXGA 3ZCDA 1UBVA 4LTVA 2ZEVA 4LFVF 4LTZA 5B03A 3ZL6A 4KQUA 3KRFB 5B0MA 1YHLA 4L2XF 2J1OA 5CG6A 5KSXF 1JFAA 4E9ZA 4NG6A 5IMNA 2H8OA 3N1VF 4H5EF 3KRPB 2OGDA 2ZCSA 4RXEA 2E8UA 2E90A 4DWGA 5B0JA 5IK0A 5IMIA 3S9VA 4NKFA 1V4JA 3KRCB 3OABA 5JA0F 1RQIA 3ZOUA 3M01A 1WL1A 2AETA 2Z50A 3AQCB 2E91A 2ZCOA 5JV1F 2RAHA 4DXJA 1DGPA 4Q23A 4XQRF 4LFEA 2O1OA 5DGSF 4MC3A 1UBXA 4OMGA 4LIXA 3NRIA 4UMJA 4KQ5A 3WCEA 3G4FA 3Q2ZA 3N46F 4E1EA 5ILJA 2Z52A 3KROB 3VJDA 1WMWA 4LZ0A 3KRCA 4LOBA 1V4EA 3DYHA 5DJRF 3ZMBA 4OKMA 3AQBB 3RYWA 5I1UA 3V66A 3ASXA 2Q58A 2E94A 4KQSA 4P0XA 3ACXA 4DZWA 5DHKA 5E8LA 2Z7HA 3VJ9A 2AZJA 1YHMA 5DGNF 2F89F 3WCDA 3VJCA 5A0KA 4JXYA 4JXNA 3WJNA 3EZ3A 2PS6A 4F6XA 3LZ9A 4RXAA 3LMDA 3OACB 3ICZA 3N3DA 2FTZA 4LLSA 4GAXA 1HX9A 3KRAB 4JZXA 3WEJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JUZ F;  4JZB A;  5DHI A;  3DYF A;  5IN8 A;  4LZC A;  4LFG A;  4GP1 A;  4LXW A;  1EZF A;  5DJV F;  1HM4 A;  3WEF A;  4FP4 A;  1RQJ A;  4RXC A;  3CP6 A;  5IMP A;  2F8C F;  1V4H A;  5DJP F;  4KUX A;  3LOM A;  3OAC A;  3LGZ B;  3WCG A;  5ILZ A;  4KFA A;  4P0W A;  4F62 A;  1YHK A;  3PYA A;  2QIS A;  4KKM A;  5E8H A;  2ZCR A;  3PKO A;  3BNX A;  5IK9 A;  3AE0 A;  1JFG A;  1N1Z A;  3LJI A;  3CKE A;  3M9U A;  2EWG A;  2Z4V A;  3M0G A;  1VG6 A;  2PS4 A;  3WE9 A;  4KPJ A;  4PVY F;  5DIQ F;  1VG7 A;  3ID0 A;  5B0I A;  5ILI A;  2E8T A;  4N9U A;  1N22 A;  2Z4X A;  1VG2 A;  4KVW A;  3MAV A;  2OPM A;  3WEG A;  3WCL A;  4NFI F;  1FPS A;  4QXS F;  4NFJ F;  1HM7 A;  3VJA A;  5ILY A;  3EFQ A;  3KBK A;  1ZW5 A;  2PS5 A;  2Z78 A;  5HNA A;  2VF6 A;  2E8W A;  3LEE A;  4XQS F;  3KRF A;  4OMH A;  1YYR A;  3KRP A;  4KVI A;  2OPN A;  5EAU A;  3V1V A;  2Z4Y A;  4DHD A;  4P0V A;  3Q30 A;  3ICN A;  3RYE A;  3ICK A;  2E92 A;  2J1P A;  3WC9 A;  3SDT A;  3MZV A;  2F94 F;  3P5P A;  5HN8 A;  5IVG A;  5IKA A;  3KB9 A;  4LLT A;  3RMG A;  5IL8 A;  4N1Z F;  4WK5 A;  3NPK A;  3P41 A;  3V1X A;  5B01 A;  4RXD A;  4F6V A;  4JVJ F;  5A0J A;  1V4I A;  5EAS A;  1N20 A;  3WJO A;  5ILH A;  2ZY1 A;  4LA5 A;  3N49 F;  3N0F A;  3M00 A;  5B02 A;  3KRO A;  1N21 A;  5IM1 A;  3B7L A;  3CC9 A;  5JV2 F;  1WY0 A;  3TS7 A;  5IK6 A;  3N5H F;  4HD1 A;  5CG5 A;  2PS8 A;  3AQ0 A;  3LVS A;  5H9D A;  3P8L A;  5JV0 F;  2F8Z F;  4NFK F;  5AFX A;  1UBW A;  5ERN A;  3RBM A;  1WL0 A;  5AHU B;  5IL3 A;  1N24 A;  1HXA A;  3N6K F;  4KWD A;  3N1W F;  5EAT A;  3P8R A;  5ILK A;  2F9K F;  4PVX F;  5DGM F;  2I19 A;  3QKC A;  4H5D F;  1YJ4 A;  3KRA A;  3VJ8 A;  1YYU A;  4EA2 A;  5IKH A;  3WCM A;  3PH7 A;  1RTR A;  3ACW A;  4LUU A;  3LG5 A;  5B0L A;  3SDV A;  2E4O A;  1WL2 A;  3SDU A;  1PS1 A;  2AEL A;  2PS7 A;  4GP2 A;  3WEK A;  3WCC A;  2E8X A;  4EA1 A;  2F7M F;  5AEL A;  4QPF A;  3OAB B;  5ER8 A;  4LA6 A;  2ZEU A;  4E9U A;  3M02 A;  3LK5 A;  3WSB A;  2ONG A;  2F92 F;  5E8K A;  4OGU A;  3ZMC A;  2Z4Z A;  3N45 F;  1VG3 A;  3LGK A;  3WCF A;  4LZ3 A;  3ADZ A;  5ERM A;  3BNY A;  2P1C A;  4OKZ A;  4K10 A;  4KVD A;  5B00 A;  4NKE A;  1YYQ A;  3LLW A;  3WEI A;  1HXC A;  3NF2 A;  3WEH A;  4JYX A;  3P5R A;  3TFP A;  4LPH F;  3APZ A;  3NPR A;  3IBA A;  4EA0 A;  3WCJ A;  5C05 A;  2Q9Z A;  4KK2 A;  3WSA A;  4XQT F;  3WCA A;  2E93 A;  2E95 A;  2E8V A;  5DW7 A;  3UCA A;  4LPG F;  3Q1O A;  4ZQ8 A;  4RYP A;  3ICM A;  3VJE A;  3WCH A;  3EGT A;  4MC8 A;  4GA3 A;  4MC0 A;  4DEM F;  3OYR A;  2Q80 A;  2Z7I A;  4H5C F;  5HN9 A;  4NUA A;  5DZ2 A;  1VG4 A;  4KPD A;  2AEK A;  1V4K A;  3TFV A;  3S4J A;  3SDR A;  1KIY A;  3W7F A;  3SDQ A;  4RNQ A;  5AYP A;  5A0I A;  1WL3 A;  1YQ7 A;  5ILD A;  3G4D A;  1WKZ A;  1N23 A;  1YYT A;  3N3L F;  1YV5 A;  3N5J F;  5B0K A;  4KVY A;  1DI1 A;  4DWB A;  5HN7 A;  2Q9Y A;  4DI5 A;  2DH4 A;  3TC1 A;  3WCI A;  3ACY A;  1KIZ A;  3IPI A;  3Q2Q A;  2OA6 A;  2ONH A;  1UBY A;  1YYS A;  3DYG A;  3TFN A;  3LSN A;  3WJK A;  3SAE A;  3QQV A;  3LDW A;  3PDE A;  2FOR A;  1N1B A;  3WCB A;  2Z4W A;  4FJQ A;  2J5C A;  2AZL A;  3PYB A;  3N0G A;  2AZK A;  5ERO A;  3VJB A;  2ZCQ A;  1HXG A;  3ZCD A;  1UBV A;  4LTV A;  2ZEV A;  4LFV F;  4LTZ A;  5B03 A;  3ZL6 A;  4KQU A;  3KRF B;  5B0M A;  1YHL A;  4L2X F;  2J1O A;  5CG6 A;  5KSX F;  1JFA A;  4E9Z A;  4NG6 A;  5IMN A;  2H8O A;  3N1V F;  4H5E F;  3KRP B;  2OGD A;  2ZCS A;  4RXE A;  2E8U A;  2E90 A;  4DWG A;  5B0J A;  5IK0 A;  5IMI A;  3S9V A;  4NKF A;  1V4J A;  3KRC B;  3OAB A;  5JA0 F;  1RQI A;  3ZOU A;  3M01 A;  1WL1 A;  2AET A;  2Z50 A;  3AQC B;  2E91 A;  2ZCO A;  5JV1 F;  2RAH A;  4DXJ A;  1DGP A;  4Q23 A;  4XQR F;  4LFE A;  2O1O A;  5DGS F;  4MC3 A;  1UBX A;  4OMG A;  4LIX A;  3NRI A;  4UMJ A;  4KQ5 A;  3WCE A;  3G4F A;  3Q2Z A;  3N46 F;  4E1E A;  5ILJ A;  2Z52 A;  3KRO B;  3VJD A;  1WMW A;  4LZ0 A;  3KRC A;  4LOB A;  1V4E A;  3DYH A;  5DJR F;  3ZMB A;  4OKM A;  3AQB B;  3RYW A;  5I1U A;  3V66 A;  3ASX A;  2Q58 A;  2E94 A;  4KQS A;  4P0X A;  3ACX A;  4DZW A;  5DHK A;  5E8L A;  2Z7H A;  3VJ9 A;  2AZJ A;  1YHM A;  5DGN F;  2F89 F;  3WCD A;  3VJC A;  5A0K A;  4JXY A;  4JXN A;  3WJN A;  3EZ3 A;  2PS6 A;  4F6X A;  3LZ9 A;  4RXA A;  3LMD A;  3OAC B;  3ICZ A;  3N3D A;  2FTZ A;  4LLS A;  4GAX A;  1HX9 A;  3KRA B;  4JZX A;  3WEJ A; 
#chains in the Genus database with same CATH topology
 5JUZ F;  4JZB A;  5DHI A;  3DYF A;  5IN8 A;  4LZC A;  4LFG A;  4GP1 A;  4LXW A;  1EZF A;  5DJV F;  1HM4 A;  3WEF A;  4FP4 A;  1RQJ A;  4RXC A;  3CP6 A;  5IMP A;  2F8C F;  1V4H A;  5DJP F;  4KUX A;  3LOM A;  3OAC A;  3LGZ B;  3WCG A;  5ILZ A;  4KFA A;  4P0W A;  4F62 A;  1YHK A;  3PYA A;  2QIS A;  4KKM A;  5E8H A;  2ZCR A;  3PKO A;  3BNX A;  5IK9 A;  3AE0 A;  1JFG A;  1N1Z A;  3LJI A;  3CKE A;  3M9U A;  2EWG A;  2Z4V A;  3M0G A;  1VG6 A;  2PS4 A;  3WE9 A;  4KPJ A;  4PVY F;  5DIQ F;  1VG7 A;  3ID0 A;  5B0I A;  5ILI A;  2E8T A;  4N9U A;  1N22 A;  2Z4X A;  1VG2 A;  4KVW A;  3MAV A;  2OPM A;  3WEG A;  3WCL A;  4NFI F;  1FPS A;  4QXS F;  4NFJ F;  1HM7 A;  3VJA A;  5ILY A;  3EFQ A;  3KBK A;  1ZW5 A;  2PS5 A;  2Z78 A;  5HNA A;  2VF6 A;  2E8W A;  3LEE A;  4XQS F;  3KRF A;  4OMH A;  1YYR A;  3KRP A;  4KVI A;  2OPN A;  5EAU A;  3V1V A;  2Z4Y A;  4DHD A;  4P0V A;  3Q30 A;  3ICN A;  3RYE A;  3ICK A;  2E92 A;  2J1P A;  3WC9 A;  3SDT A;  3MZV A;  2F94 F;  3P5P A;  5HN8 A;  5IVG A;  5IKA A;  3KB9 A;  4LLT A;  3RMG A;  5IL8 A;  4N1Z F;  4WK5 A;  3NPK A;  3P41 A;  3V1X A;  5B01 A;  4RXD A;  4F6V A;  4JVJ F;  5A0J A;  1V4I A;  5EAS A;  1N20 A;  3WJO A;  5ILH A;  2ZY1 A;  4LA5 A;  3N49 F;  3N0F A;  3M00 A;  5B02 A;  3KRO A;  1N21 A;  5IM1 A;  3B7L A;  3CC9 A;  5JV2 F;  1WY0 A;  3TS7 A;  5IK6 A;  3N5H F;  4HD1 A;  5CG5 A;  2PS8 A;  3AQ0 A;  3LVS A;  5H9D A;  3P8L A;  5JV0 F;  2F8Z F;  4NFK F;  5AFX A;  1UBW A;  5ERN A;  3RBM A;  1WL0 A;  5AHU B;  5IL3 A;  1N24 A;  1HXA A;  3N6K F;  4KWD A;  3N1W F;  5EAT A;  3P8R A;  5ILK A;  2F9K F;  4PVX F;  5DGM F;  2I19 A;  3QKC A;  4H5D F;  1YJ4 A;  3KRA A;  3VJ8 A;  1YYU A;  4EA2 A;  5IKH A;  3WCM A;  3PH7 A;  1RTR A;  3ACW A;  4LUU A;  3LG5 A;  5B0L A;  3SDV A;  2E4O A;  1WL2 A;  3SDU A;  1PS1 A;  2AEL A;  2PS7 A;  4GP2 A;  3WEK A;  3WCC A;  2E8X A;  4EA1 A;  2F7M F;  5AEL A;  4QPF A;  3OAB B;  5ER8 A;  4LA6 A;  2ZEU A;  4E9U A;  3M02 A;  3LK5 A;  3WSB A;  2ONG A;  2F92 F;  5E8K A;  4OGU A;  3ZMC A;  2Z4Z A;  3N45 F;  1VG3 A;  3LGK A;  3WCF A;  4LZ3 A;  3ADZ A;  5ERM A;  3BNY A;  2P1C A;  4OKZ A;  4K10 A;  4KVD A;  5B00 A;  4NKE A;  1YYQ A;  3LLW A;  3WEI A;  1HXC A;  3NF2 A;  3WEH A;  4JYX A;  3P5R A;  3TFP A;  4LPH F;  3APZ A;  3NPR A;  3IBA A;  4EA0 A;  3WCJ A;  5C05 A;  2Q9Z A;  4KK2 A;  3WSA A;  4XQT F;  3WCA A;  2E93 A;  2E95 A;  2E8V A;  5DW7 A;  3UCA A;  4LPG F;  3Q1O A;  4ZQ8 A;  4RYP A;  3ICM A;  3VJE A;  3WCH A;  3EGT A;  4MC8 A;  4GA3 A;  4MC0 A;  4DEM F;  3OYR A;  2Q80 A;  2Z7I A;  4H5C F;  5HN9 A;  4NUA A;  5DZ2 A;  1VG4 A;  4KPD A;  2AEK A;  1V4K A;  3TFV A;  3S4J A;  3SDR A;  1KIY A;  3W7F A;  3SDQ A;  4RNQ A;  5AYP A;  5A0I A;  1WL3 A;  1YQ7 A;  5ILD A;  3G4D A;  1WKZ A;  1N23 A;  1YYT A;  3N3L F;  1YV5 A;  3N5J F;  5B0K A;  4KVY A;  1DI1 A;  4DWB A;  5HN7 A;  2Q9Y A;  4DI5 A;  2DH4 A;  3TC1 A;  3WCI A;  3ACY A;  1KIZ A;  3IPI A;  3Q2Q A;  2OA6 A;  2ONH A;  1UBY A;  1YYS A;  3DYG A;  3TFN A;  3LSN A;  3WJK A;  3SAE A;  3QQV A;  3LDW A;  3PDE A;  2FOR A;  1N1B A;  3WCB A;  2Z4W A;  4FJQ A;  2J5C A;  2AZL A;  3PYB A;  3N0G A;  2AZK A;  5ERO A;  3VJB A;  2ZCQ A;  1HXG A;  3ZCD A;  1UBV A;  4LTV A;  2ZEV A;  4LFV F;  4LTZ A;  5B03 A;  3ZL6 A;  4KQU A;  3KRF B;  5B0M A;  1YHL A;  4L2X F;  2J1O A;  5CG6 A;  5KSX F;  1JFA A;  4E9Z A;  4NG6 A;  5IMN A;  2H8O A;  3N1V F;  4H5E F;  3KRP B;  2OGD A;  2ZCS A;  4RXE A;  2E8U A;  2E90 A;  4DWG A;  5B0J A;  5IK0 A;  5IMI A;  3S9V A;  4NKF A;  1V4J A;  3KRC B;  3OAB A;  5JA0 F;  1RQI A;  3ZOU A;  3M01 A;  1WL1 A;  2AET A;  2Z50 A;  3AQC B;  2E91 A;  2ZCO A;  5JV1 F;  2RAH A;  4DXJ A;  1DGP A;  4Q23 A;  4XQR F;  4LFE A;  2O1O A;  5DGS F;  4MC3 A;  1UBX A;  4OMG A;  4LIX A;  3NRI A;  4UMJ A;  4KQ5 A;  3WCE A;  3G4F A;  3Q2Z A;  3N46 F;  4E1E A;  5ILJ A;  2Z52 A;  3KRO B;  3VJD A;  1WMW A;  4LZ0 A;  3KRC A;  4LOB A;  1V4E A;  3DYH A;  5DJR F;  3ZMB A;  4OKM A;  3AQB B;  3RYW A;  5I1U A;  3V66 A;  3ASX A;  2Q58 A;  2E94 A;  4KQS A;  4P0X A;  3ACX A;  4DZW A;  5DHK A;  5E8L A;  2Z7H A;  3VJ9 A;  2AZJ A;  1YHM A;  5DGN F;  2F89 F;  3WCD A;  3VJC A;  5A0K A;  4JXY A;  4JXN A;  3WJN A;  3EZ3 A;  2PS6 A;  4F6X A;  3LZ9 A;  4RXA A;  3LMD A;  3OAC B;  3ICZ A;  3N3D A;  2FTZ A;  4LLS A;  4GAX A;  1HX9 A;  3KRA B;  4JZX A;  3WEJ A; 
#chains in the Genus database with same CATH homology
 5JUZ F;  4JZB A;  5DHI A;  3DYF A;  5IN8 A;  4LZC A;  4LFG A;  4GP1 A;  4LXW A;  1EZF A;  5DJV F;  1HM4 A;  3WEF A;  4FP4 A;  1RQJ A;  4RXC A;  3CP6 A;  5IMP A;  2F8C F;  1V4H A;  5DJP F;  4KUX A;  3LOM A;  3OAC A;  3LGZ B;  3WCG A;  5ILZ A;  4KFA A;  4P0W A;  4F62 A;  1YHK A;  3PYA A;  2QIS A;  4KKM A;  5E8H A;  2ZCR A;  3PKO A;  3BNX A;  5IK9 A;  3AE0 A;  1JFG A;  1N1Z A;  3LJI A;  3CKE A;  3M9U A;  2EWG A;  2Z4V A;  3M0G A;  1VG6 A;  2PS4 A;  3WE9 A;  4KPJ A;  4PVY F;  5DIQ F;  1VG7 A;  3ID0 A;  5B0I A;  5ILI A;  2E8T A;  4N9U A;  1N22 A;  2Z4X A;  1VG2 A;  4KVW A;  3MAV A;  2OPM A;  3WEG A;  3WCL A;  4NFI F;  1FPS A;  4QXS F;  4NFJ F;  1HM7 A;  3VJA A;  5ILY A;  3EFQ A;  3KBK A;  1ZW5 A;  2PS5 A;  2Z78 A;  5HNA A;  2VF6 A;  2E8W A;  3LEE A;  4XQS F;  3KRF A;  4OMH A;  1YYR A;  3KRP A;  4KVI A;  2OPN A;  5EAU A;  3V1V A;  2Z4Y A;  4DHD A;  4P0V A;  3Q30 A;  3ICN A;  3RYE A;  3ICK A;  2E92 A;  2J1P A;  3WC9 A;  3SDT A;  3MZV A;  2F94 F;  3P5P A;  5HN8 A;  5IVG A;  5IKA A;  3KB9 A;  4LLT A;  3RMG A;  5IL8 A;  4N1Z F;  4WK5 A;  3NPK A;  3P41 A;  3V1X A;  5B01 A;  4RXD A;  4F6V A;  4JVJ F;  5A0J A;  1V4I A;  5EAS A;  1N20 A;  3WJO A;  5ILH A;  2ZY1 A;  4LA5 A;  3N49 F;  3N0F A;  3M00 A;  5B02 A;  3KRO A;  1N21 A;  5IM1 A;  3B7L A;  3CC9 A;  5JV2 F;  1WY0 A;  3TS7 A;  5IK6 A;  3N5H F;  4HD1 A;  5CG5 A;  2PS8 A;  3AQ0 A;  3LVS A;  5H9D A;  3P8L A;  5JV0 F;  2F8Z F;  4NFK F;  5AFX A;  1UBW A;  5ERN A;  3RBM A;  1WL0 A;  5AHU B;  5IL3 A;  1N24 A;  1HXA A;  3N6K F;  4KWD A;  3N1W F;  5EAT A;  3P8R A;  5ILK A;  2F9K F;  4PVX F;  5DGM F;  2I19 A;  3QKC A;  4H5D F;  1YJ4 A;  3KRA A;  3VJ8 A;  1YYU A;  4EA2 A;  5IKH A;  3WCM A;  3PH7 A;  1RTR A;  3ACW A;  4LUU A;  3LG5 A;  5B0L A;  3SDV A;  2E4O A;  1WL2 A;  3SDU A;  1PS1 A;  2AEL A;  2PS7 A;  4GP2 A;  3WEK A;  3WCC A;  2E8X A;  4EA1 A;  2F7M F;  5AEL A;  4QPF A;  3OAB B;  5ER8 A;  4LA6 A;  2ZEU A;  4E9U A;  3M02 A;  3LK5 A;  3WSB A;  2ONG A;  2F92 F;  5E8K A;  4OGU A;  3ZMC A;  2Z4Z A;  3N45 F;  1VG3 A;  3LGK A;  3WCF A;  4LZ3 A;  3ADZ A;  5ERM A;  3BNY A;  2P1C A;  4OKZ A;  4K10 A;  4KVD A;  5B00 A;  4NKE A;  1YYQ A;  3LLW A;  3WEI A;  1HXC A;  3NF2 A;  3WEH A;  4JYX A;  3P5R A;  3TFP A;  4LPH F;  3APZ A;  3NPR A;  3IBA A;  4EA0 A;  3WCJ A;  5C05 A;  2Q9Z A;  4KK2 A;  3WSA A;  4XQT F;  3WCA A;  2E93 A;  2E95 A;  2E8V A;  5DW7 A;  3UCA A;  4LPG F;  3Q1O A;  4ZQ8 A;  4RYP A;  3ICM A;  3VJE A;  3WCH A;  3EGT A;  4MC8 A;  4GA3 A;  4MC0 A;  4DEM F;  3OYR A;  2Q80 A;  2Z7I A;  4H5C F;  5HN9 A;  4NUA A;  5DZ2 A;  1VG4 A;  4KPD A;  2AEK A;  1V4K A;  3TFV A;  3S4J A;  3SDR A;  1KIY A;  3W7F A;  3SDQ A;  4RNQ A;  5AYP A;  5A0I A;  1WL3 A;  1YQ7 A;  5ILD A;  3G4D A;  1WKZ A;  1N23 A;  1YYT A;  3N3L F;  1YV5 A;  3N5J F;  5B0K A;  4KVY A;  1DI1 A;  4DWB A;  5HN7 A;  2Q9Y A;  4DI5 A;  2DH4 A;  3TC1 A;  3WCI A;  3ACY A;  1KIZ A;  3IPI A;  3Q2Q A;  2OA6 A;  2ONH A;  1UBY A;  1YYS A;  3DYG A;  3TFN A;  3LSN A;  3WJK A;  3SAE A;  3QQV A;  3LDW A;  3PDE A;  2FOR A;  1N1B A;  3WCB A;  2Z4W A;  4FJQ A;  2J5C A;  2AZL A;  3PYB A;  3N0G A;  2AZK A;  5ERO A;  3VJB A;  2ZCQ A;  1HXG A;  3ZCD A;  1UBV A;  4LTV A;  2ZEV A;  4LFV F;  4LTZ A;  5B03 A;  3ZL6 A;  4KQU A;  3KRF B;  5B0M A;  1YHL A;  4L2X F;  2J1O A;  5CG6 A;  5KSX F;  1JFA A;  4E9Z A;  4NG6 A;  5IMN A;  2H8O A;  3N1V F;  4H5E F;  3KRP B;  2OGD A;  2ZCS A;  4RXE A;  2E8U A;  2E90 A;  4DWG A;  5B0J A;  5IK0 A;  5IMI A;  3S9V A;  4NKF A;  1V4J A;  3KRC B;  3OAB A;  5JA0 F;  1RQI A;  3ZOU A;  3M01 A;  1WL1 A;  2AET A;  2Z50 A;  3AQC B;  2E91 A;  2ZCO A;  5JV1 F;  2RAH A;  4DXJ A;  1DGP A;  4Q23 A;  4XQR F;  4LFE A;  2O1O A;  5DGS F;  4MC3 A;  1UBX A;  4OMG A;  4LIX A;  3NRI A;  4UMJ A;  4KQ5 A;  3WCE A;  3G4F A;  3Q2Z A;  3N46 F;  4E1E A;  5ILJ A;  2Z52 A;  3KRO B;  3VJD A;  1WMW A;  4LZ0 A;  3KRC A;  4LOB A;  1V4E A;  3DYH A;  5DJR F;  3ZMB A;  4OKM A;  3AQB B;  3RYW A;  5I1U A;  3V66 A;  3ASX A;  2Q58 A;  2E94 A;  4KQS A;  4P0X A;  3ACX A;  4DZW A;  5DHK A;  5E8L A;  2Z7H A;  3VJ9 A;  2AZJ A;  1YHM A;  5DGN F;  2F89 F;  3WCD A;  3VJC A;  5A0K A;  4JXY A;  4JXN A;  3WJN A;  3EZ3 A;  2PS6 A;  4F6X A;  3LZ9 A;  4RXA A;  3LMD A;  3OAC B;  3ICZ A;  3N3D A;  2FTZ A;  4LLS A;  4GAX A;  1HX9 A;  3KRA B;  4JZX A;  3WEJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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