5JV1F

Crystal structure of human fpps in complex with an allosteric inhibitor cl-08-066
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
342
structure length
336
Chain Sequence
VYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Farnesyl pyrophosphate synthase
publication title Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 125
structure length 336
sequence length 342
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2016-05-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 5jv1F00
3BNXA 3RMGA 5DGNF 3W7FA 3N0GA 3KRPA 4FP4A 3PYAA 2OA6A 3TFVA 4KUXA 3ICMA 1VG6A 3WE9A 4KPDA 3WJOA 1WL1A 2PS7A 3N49F 3P5RA 2FTZA 3WEHA 2ONGA 4KQSA 5DIQF 3UCAA 5A0IA 3M9UA 1KIYA 3VJ8A 2VF6A 4Q23A 5B02A 1WY0A 5IMIA 1YYUA 2RAHA 3P41A 4F6VA 4L2XF 3OACA 3WEKA 3AE0A 4K10A 5HN8A 4N1ZF 2Z78A 4JXYA 5HN9A 5ERMA 1KIZA 3NPKA 4NFKF 4LUUA 5B03A 4PVXF 3QKCA 3WCBA 1V4JA 2OPMA 4NKEA 4ZQ8A 4DEMF 2OGDA 2E95A 3VJAA 3LDWA 5IM1A 1N20A 4DZWA 5DHKA 3PDEA 3KRPB 1N1ZA 5DGMF 3WCAA 4QXSF 3NRIA 2I19A 3P8RA 2Z4XA 1DI1A 3WCJA 4MC3A 1N24A 1N21A 1YHLA 3BNYA 3TFNA 1EZFA 4LLSA 4FJQA 4RXAA 5B0JA 4JYXA 3N5HF 4KQ5A 1YJ4A 2Z50A 1DGPA 5IVGA 4RXEA 1VG3A 3MAVA 4UMJA 3LSNA 3S9VA 3WCDA 5DHIA 5A0KA 2DH4A 2E93A 2OPNA 1VG2A 4XQTF 5AHUB 4LPGF 1YYTA 3LGZB 3CP6A 4F6XA 1WL3A 4LZ3A 4EA2A 1YHMA 5B0IA 5EASA 3G4DA 5IK9A 3IBAA 4EA0A 3DYFA 5B0LA 4LZ0A 3WEJA 3Q2QA 2AEKA 4WK5A 5IL8A 3NF2A 4NKFA 5IKHA 2Z4YA 2QISA 2E8WA 3SDRA 2Z4WA 4KPJA 5A0JA 3PH7A 3LMDA 3ICZA 2E8UA 2F8ZF 3LLWA 5ILHA 3EFQA 3N5JF 4KWDA 3ZCDA 4JXNA 5DZ2A 1YYQA 3RBMA 3AQCB 4MC8A 5ERNA 4H5CF 4NG6A 1HM4A 4N9UA 4NUAA 4H5EF 3KRCB 3VJ9A 2F8CF 3SDUA 3AQ0A 4E9UA 3EZ3A 1UBXA 5AELA 3B7LA 3TFPA 2E94A 2Z4VA 1HM7A 5E8LA 1V4EA 5JUZF 1JFGA 1WMWA 4KFAA 2ZCOA 4MC0A 1UBVA 3DYGA 5IK0A 3N6KF 2Q9ZA 1UBWA 4LFVF 5IK6A 2ONHA 3ICKA 4JVJF 3VJEA 3WC9A 3N45F 3WSBA 1WKZA 3N1WF 3N3DA 3RYEA 4KVIA 3KRFB 5ILKA 4GA3A 1HX9A 3LJIA 2PS4A 3N3LF 4XQSF 4P0XA 3WSAA 3MZVA 5DJVF 4RNQA 3WCLA 4P0WA 2E8TA 4GAXA 4LXWA 3OYRA 4HD1A 5AYPA 3KROB 1N23A 5IN8A 5KSXF 3WEGA 1V4HA 5DJRF 2ZCQA 2F89F 3V66A 2O1OA 5E8HA 3WCGA 3WJNA 3N46F 4LOBA 5ILDA 3KRCA 2F7MF 2AZJA 1VG7A 4LFGA 5EROA 3ADZA 5CG6A 3CKEA 5DGSF 3ZMCA 3TC1A 2PS8A 4DWBA 3SDTA 3LOMA 3APZA 2Q80A 5ILIA 2ZCSA 4KVYA 2Z4ZA 4JZXA 4RXCA 3EGTA 2E92A 3WEIA 3LZ9A 3PKOA 5DW7A 2J1OA 2J5CA 1VG4A 3KRFA 3ZL6A 2PS5A 3V1XA 3IPIA 5EATA 2ZEVA 4P0VA 3OABB 4OKZA 1PS1A 5AFXA 3ID0A 5E8KA 3RYWA 5B01A 4KKMA 3Q1OA 3M01A 3V1VA 1YQ7A 3LG5A 5ER8A 3G4FA 3KROA 3ASXA 2H8OA 3N0FA 5CG5A 4LZCA 3ACXA 3P8LA 5ILYA 5HNAA 4GP2A 4OKMA 3KB9A 5JV1F 5IMPA 1N22A 4LFEA 4H5DF 5IL3A 1RTRA 1RQIA 1WL0A 4E9ZA 3KBKA 4LIXA 4LA5A 5EAUA 2Z7IA 3DYHA 3KRAB 4OMGA 3WCCA 3LVSA 1HXGA 1YYSA 2E91A 4PVYF 5B00A 5ILZA 2AZKA 4DWGA 3PYBA 4XQRF 3Q2ZA 3LGKA 4KVDA 3Q30A 4NFJF 3SAEA 4JZBA 3WCMA 5B0KA 2ZCRA 1RQJA 4KK2A 4RXDA 4QPFA 3CC9A 1HXCA 1FPSA 2Q58A 3ICNA 2F94F 2P1CA 3WJKA 1HXAA 3OABA 2FORA 3VJDA 3NPRA 4KVWA 1V4KA 3AQBB 3M02A 1WL2A 3ACWA 3M0GA 3SDQA 5IMNA 5IKAA 4GP1A 2J1PA 1UBYA 3ACYA 5HN7A 3VJCA 5I1UA 2Z7HA 5JV2F 4LLTA 3N1VF 1YHKA 1JFAA 4E1EA 1ZW5A 2PS6A 3P5PA 3QQVA 2ZEUA 3S4JA 5C05A 3WCFA 1YV5A 3LEEA 2Z52A 3KRAA 2E90A 4LTVA 5ILJA 5DJPF 4NFIF 5B0MA 3WCIA 3WCEA 4LA6A 1YYRA 5JV0F 2F92F 5JA0F 4DI5A 3ZMBA 2ZY1A 4LPHF 3WCHA 3ZOUA 4EA1A 3OACB 2E8XA 4F62A 1N1BA 2AELA 3SDVA 2E4OA 4RYPA 2AZLA 3LK5A 2E8VA 4OMHA 3M00A 4DHDA 4DXJA 4OGUA 2AETA 3VJBA 2F9KF 3WEFA 4LTZA 2EWGA 5H9DA 4KQUA 3TS7A 2Q9YA 1V4IA
chains in the Genus database with same CATH superfamily
3BNXA 3RMGA 5DGNF 3W7FA 3N0GA 3KRPA 4FP4A 3PYAA 2OA6A 3TFVA 4KUXA 3ICMA 1VG6A 3WE9A 4KPDA 3WJOA 1WL1A 2PS7A 3N49F 3P5RA 2FTZA 3WEHA 2ONGA 4KQSA 5DIQF 3UCAA 5A0IA 3M9UA 1KIYA 3VJ8A 2VF6A 4Q23A 5B02A 1WY0A 5IMIA 1YYUA 2RAHA 3P41A 4F6VA 4L2XF 3OACA 3WEKA 3AE0A 4K10A 5HN8A 4N1ZF 2Z78A 4JXYA 5HN9A 5ERMA 1KIZA 3NPKA 4NFKF 4LUUA 5B03A 4PVXF 3QKCA 3WCBA 1V4JA 2OPMA 4NKEA 4ZQ8A 4DEMF 2OGDA 2E95A 3VJAA 3LDWA 5IM1A 1N20A 4DZWA 5DHKA 3PDEA 3KRPB 1N1ZA 5DGMF 3WCAA 4QXSF 3NRIA 2I19A 3P8RA 2Z4XA 1DI1A 3WCJA 4MC3A 1N24A 1N21A 1YHLA 3BNYA 3TFNA 1EZFA 4LLSA 4FJQA 4RXAA 5B0JA 4JYXA 3N5HF 4KQ5A 1YJ4A 2Z50A 1DGPA 5IVGA 4RXEA 1VG3A 3MAVA 4UMJA 3LSNA 3S9VA 3WCDA 5DHIA 5A0KA 2DH4A 2E93A 2OPNA 1VG2A 4XQTF 5AHUB 4LPGF 1YYTA 3LGZB 3CP6A 4F6XA 1WL3A 4LZ3A 4EA2A 1YHMA 5B0IA 5EASA 3G4DA 5IK9A 3IBAA 4EA0A 3DYFA 5B0LA 4LZ0A 3WEJA 3Q2QA 2AEKA 4WK5A 5IL8A 3NF2A 4NKFA 5IKHA 2Z4YA 2QISA 2E8WA 3SDRA 2Z4WA 4KPJA 5A0JA 3PH7A 3LMDA 3ICZA 2E8UA 2F8ZF 3LLWA 5ILHA 3EFQA 3N5JF 4KWDA 3ZCDA 4JXNA 5DZ2A 1YYQA 3RBMA 3AQCB 4MC8A 5ERNA 4H5CF 4NG6A 1HM4A 4N9UA 4NUAA 4H5EF 3KRCB 3VJ9A 2F8CF 3SDUA 3AQ0A 4E9UA 3EZ3A 1UBXA 5AELA 3B7LA 3TFPA 2E94A 2Z4VA 1HM7A 5E8LA 1V4EA 5JUZF 1JFGA 1WMWA 4KFAA 2ZCOA 4MC0A 1UBVA 3DYGA 5IK0A 3N6KF 2Q9ZA 1UBWA 4LFVF 5IK6A 2ONHA 3ICKA 4JVJF 3VJEA 3WC9A 3N45F 3WSBA 1WKZA 3N1WF 3N3DA 3RYEA 4KVIA 3KRFB 5ILKA 4GA3A 1HX9A 3LJIA 2PS4A 3N3LF 4XQSF 4P0XA 3WSAA 3MZVA 5DJVF 4RNQA 3WCLA 4P0WA 2E8TA 4GAXA 4LXWA 3OYRA 4HD1A 5AYPA 3KROB 1N23A 5IN8A 5KSXF 3WEGA 1V4HA 5DJRF 2ZCQA 2F89F 3V66A 2O1OA 5E8HA 3WCGA 3WJNA 3N46F 4LOBA 5ILDA 3KRCA 2F7MF 2AZJA 1VG7A 4LFGA 5EROA 3ADZA 5CG6A 3CKEA 5DGSF 3ZMCA 3TC1A 2PS8A 4DWBA 3SDTA 3LOMA 3APZA 2Q80A 5ILIA 2ZCSA 4KVYA 2Z4ZA 4JZXA 4RXCA 3EGTA 2E92A 3WEIA 3LZ9A 3PKOA 5DW7A 2J1OA 2J5CA 1VG4A 3KRFA 3ZL6A 2PS5A 3V1XA 3IPIA 5EATA 2ZEVA 4P0VA 3OABB 4OKZA 1PS1A 5AFXA 3ID0A 5E8KA 3RYWA 5B01A 4KKMA 3Q1OA 3M01A 3V1VA 1YQ7A 3LG5A 5ER8A 3G4FA 3KROA 3ASXA 2H8OA 3N0FA 5CG5A 4LZCA 3ACXA 3P8LA 5ILYA 5HNAA 4GP2A 4OKMA 3KB9A 5JV1F 5IMPA 1N22A 4LFEA 4H5DF 5IL3A 1RTRA 1RQIA 1WL0A 4E9ZA 3KBKA 4LIXA 4LA5A 5EAUA 2Z7IA 3DYHA 3KRAB 4OMGA 3WCCA 3LVSA 1HXGA 1YYSA 2E91A 4PVYF 5B00A 5ILZA 2AZKA 4DWGA 3PYBA 4XQRF 3Q2ZA 3LGKA 4KVDA 3Q30A 4NFJF 3SAEA 4JZBA 3WCMA 5B0KA 2ZCRA 1RQJA 4KK2A 4RXDA 4QPFA 3CC9A 1HXCA 1FPSA 2Q58A 3ICNA 2F94F 2P1CA 3WJKA 1HXAA 3OABA 2FORA 3VJDA 3NPRA 4KVWA 1V4KA 3AQBB 3M02A 1WL2A 3ACWA 3M0GA 3SDQA 5IMNA 5IKAA 4GP1A 2J1PA 1UBYA 3ACYA 5HN7A 3VJCA 5I1UA 2Z7HA 5JV2F 4LLTA 3N1VF 1YHKA 1JFAA 4E1EA 1ZW5A 2PS6A 3P5PA 3QQVA 2ZEUA 3S4JA 5C05A 3WCFA 1YV5A 3LEEA 2Z52A 3KRAA 2E90A 4LTVA 5ILJA 5DJPF 4NFIF 5B0MA 3WCIA 3WCEA 4LA6A 1YYRA 5JV0F 2F92F 5JA0F 4DI5A 3ZMBA 2ZY1A 4LPHF 3WCHA 3ZOUA 4EA1A 3OACB 2E8XA 4F62A 1N1BA 2AELA 3SDVA 2E4OA 4RYPA 2AZLA 3LK5A 2E8VA 4OMHA 3M00A 4DHDA 4DXJA 4OGUA 2AETA 3VJBA 2F9KF 3WEFA 4LTZA 2EWGA 5H9DA 4KQUA 3TS7A 2Q9YA 1V4IA
chains in the Genus database with same CATH topology
3BNXA 3RMGA 5DGNF 3W7FA 3N0GA 3KRPA 4FP4A 3PYAA 2OA6A 3TFVA 4KUXA 3ICMA 1VG6A 3WE9A 4KPDA 3WJOA 1WL1A 2PS7A 3N49F 3P5RA 2FTZA 3WEHA 2ONGA 4KQSA 5DIQF 3UCAA 5A0IA 3M9UA 1KIYA 3VJ8A 2VF6A 4Q23A 5B02A 1WY0A 5IMIA 1YYUA 2RAHA 3P41A 4F6VA 4L2XF 3OACA 3WEKA 3AE0A 4K10A 5HN8A 4N1ZF 2Z78A 4JXYA 5HN9A 5ERMA 1KIZA 3NPKA 4NFKF 4LUUA 5B03A 4PVXF 3QKCA 3WCBA 1V4JA 2OPMA 4NKEA 4ZQ8A 4DEMF 2OGDA 2E95A 3VJAA 3LDWA 5IM1A 1N20A 4DZWA 5DHKA 3PDEA 3KRPB 1N1ZA 5DGMF 3WCAA 4QXSF 3NRIA 2I19A 3P8RA 2Z4XA 1DI1A 3WCJA 4MC3A 1N24A 1N21A 1YHLA 3BNYA 3TFNA 1EZFA 4LLSA 4FJQA 4RXAA 5B0JA 4JYXA 3N5HF 4KQ5A 1YJ4A 2Z50A 1DGPA 5IVGA 4RXEA 1VG3A 3MAVA 4UMJA 3LSNA 3S9VA 3WCDA 5DHIA 5A0KA 2DH4A 2E93A 2OPNA 1VG2A 4XQTF 5AHUB 4LPGF 1YYTA 3LGZB 3CP6A 4F6XA 1WL3A 4LZ3A 4EA2A 1YHMA 5B0IA 5EASA 3G4DA 5IK9A 3IBAA 4EA0A 3DYFA 5B0LA 4LZ0A 3WEJA 3Q2QA 2AEKA 4WK5A 5IL8A 3NF2A 4NKFA 5IKHA 2Z4YA 2QISA 2E8WA 3SDRA 2Z4WA 4KPJA 5A0JA 3PH7A 3LMDA 3ICZA 2E8UA 2F8ZF 3LLWA 5ILHA 3EFQA 3N5JF 4KWDA 3ZCDA 4JXNA 5DZ2A 1YYQA 3RBMA 3AQCB 4MC8A 5ERNA 4H5CF 4NG6A 1HM4A 4N9UA 4NUAA 4H5EF 3KRCB 3VJ9A 2F8CF 3SDUA 3AQ0A 4E9UA 3EZ3A 1UBXA 5AELA 3B7LA 3TFPA 2E94A 2Z4VA 1HM7A 5E8LA 1V4EA 5JUZF 1JFGA 1WMWA 4KFAA 2ZCOA 4MC0A 1UBVA 3DYGA 5IK0A 3N6KF 2Q9ZA 1UBWA 4LFVF 5IK6A 2ONHA 3ICKA 4JVJF 3VJEA 3WC9A 3N45F 3WSBA 1WKZA 3N1WF 3N3DA 3RYEA 4KVIA 3KRFB 5ILKA 4GA3A 1HX9A 3LJIA 2PS4A 3N3LF 4XQSF 4P0XA 3WSAA 3MZVA 5DJVF 4RNQA 3WCLA 4P0WA 2E8TA 4GAXA 4LXWA 3OYRA 4HD1A 5AYPA 3KROB 1N23A 5IN8A 5KSXF 3WEGA 1V4HA 5DJRF 2ZCQA 2F89F 3V66A 2O1OA 5E8HA 3WCGA 3WJNA 3N46F 4LOBA 5ILDA 3KRCA 2F7MF 2AZJA 1VG7A 4LFGA 5EROA 3ADZA 5CG6A 3CKEA 5DGSF 3ZMCA 3TC1A 2PS8A 4DWBA 3SDTA 3LOMA 3APZA 2Q80A 5ILIA 2ZCSA 4KVYA 2Z4ZA 4JZXA 4RXCA 3EGTA 2E92A 3WEIA 3LZ9A 3PKOA 5DW7A 2J1OA 2J5CA 1VG4A 3KRFA 3ZL6A 2PS5A 3V1XA 3IPIA 5EATA 2ZEVA 4P0VA 3OABB 4OKZA 1PS1A 5AFXA 3ID0A 5E8KA 3RYWA 5B01A 4KKMA 3Q1OA 3M01A 3V1VA 1YQ7A 3LG5A 5ER8A 3G4FA 3KROA 3ASXA 2H8OA 3N0FA 5CG5A 4LZCA 3ACXA 3P8LA 5ILYA 5HNAA 4GP2A 4OKMA 3KB9A 5JV1F 5IMPA 1N22A 4LFEA 4H5DF 5IL3A 1RTRA 1RQIA 1WL0A 4E9ZA 3KBKA 4LIXA 4LA5A 5EAUA 2Z7IA 3DYHA 3KRAB 4OMGA 3WCCA 3LVSA 1HXGA 1YYSA 2E91A 4PVYF 5B00A 5ILZA 2AZKA 4DWGA 3PYBA 4XQRF 3Q2ZA 3LGKA 4KVDA 3Q30A 4NFJF 3SAEA 4JZBA 3WCMA 5B0KA 2ZCRA 1RQJA 4KK2A 4RXDA 4QPFA 3CC9A 1HXCA 1FPSA 2Q58A 3ICNA 2F94F 2P1CA 3WJKA 1HXAA 3OABA 2FORA 3VJDA 3NPRA 4KVWA 1V4KA 3AQBB 3M02A 1WL2A 3ACWA 3M0GA 3SDQA 5IMNA 5IKAA 4GP1A 2J1PA 1UBYA 3ACYA 5HN7A 3VJCA 5I1UA 2Z7HA 5JV2F 4LLTA 3N1VF 1YHKA 1JFAA 4E1EA 1ZW5A 2PS6A 3P5PA 3QQVA 2ZEUA 3S4JA 5C05A 3WCFA 1YV5A 3LEEA 2Z52A 3KRAA 2E90A 4LTVA 5ILJA 5DJPF 4NFIF 5B0MA 3WCIA 3WCEA 4LA6A 1YYRA 5JV0F 2F92F 5JA0F 4DI5A 3ZMBA 2ZY1A 4LPHF 3WCHA 3ZOUA 4EA1A 3OACB 2E8XA 4F62A 1N1BA 2AELA 3SDVA 2E4OA 4RYPA 2AZLA 3LK5A 2E8VA 4OMHA 3M00A 4DHDA 4DXJA 4OGUA 2AETA 3VJBA 2F9KF 3WEFA 4LTZA 2EWGA 5H9DA 4KQUA 3TS7A 2Q9YA 1V4IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BNX A;  3RMG A;  5DGN F;  3W7F A;  3N0G A;  3KRP A;  4FP4 A;  3PYA A;  2OA6 A;  3TFV A;  4KUX A;  3ICM A;  1VG6 A;  3WE9 A;  4KPD A;  3WJO A;  1WL1 A;  2PS7 A;  3N49 F;  3P5R A;  2FTZ A;  3WEH A;  2ONG A;  4KQS A;  5DIQ F;  3UCA A;  5A0I A;  3M9U A;  1KIY A;  3VJ8 A;  2VF6 A;  4Q23 A;  5B02 A;  1WY0 A;  5IMI A;  1YYU A;  2RAH A;  3P41 A;  4F6V A;  4L2X F;  3OAC A;  3WEK A;  3AE0 A;  4K10 A;  5HN8 A;  4N1Z F;  2Z78 A;  4JXY A;  5HN9 A;  5ERM A;  1KIZ A;  3NPK A;  4NFK F;  4LUU A;  5B03 A;  4PVX F;  3QKC A;  3WCB A;  1V4J A;  2OPM A;  4NKE A;  4ZQ8 A;  4DEM F;  2OGD A;  2E95 A;  3VJA A;  3LDW A;  5IM1 A;  1N20 A;  4DZW A;  5DHK A;  3PDE A;  3KRP B;  1N1Z A;  5DGM F;  3WCA A;  4QXS F;  3NRI A;  2I19 A;  3P8R A;  2Z4X A;  1DI1 A;  3WCJ A;  4MC3 A;  1N24 A;  1N21 A;  1YHL A;  3BNY A;  3TFN A;  1EZF A;  4LLS A;  4FJQ A;  4RXA A;  5B0J A;  4JYX A;  3N5H F;  4KQ5 A;  1YJ4 A;  2Z50 A;  1DGP A;  5IVG A;  4RXE A;  1VG3 A;  3MAV A;  4UMJ A;  3LSN A;  3S9V A;  3WCD A;  5DHI A;  5A0K A;  2DH4 A;  2E93 A;  2OPN A;  1VG2 A;  4XQT F;  5AHU B;  4LPG F;  1YYT A;  3LGZ B;  3CP6 A;  4F6X A;  1WL3 A;  4LZ3 A;  4EA2 A;  1YHM A;  5B0I A;  5EAS A;  3G4D A;  5IK9 A;  3IBA A;  4EA0 A;  3DYF A;  5B0L A;  4LZ0 A;  3WEJ A;  3Q2Q A;  2AEK A;  4WK5 A;  5IL8 A;  3NF2 A;  4NKF A;  5IKH A;  2Z4Y A;  2QIS A;  2E8W A;  3SDR A;  2Z4W A;  4KPJ A;  5A0J A;  3PH7 A;  3LMD A;  3ICZ A;  2E8U A;  2F8Z F;  3LLW A;  5ILH A;  3EFQ A;  3N5J F;  4KWD A;  3ZCD A;  4JXN A;  5DZ2 A;  1YYQ A;  3RBM A;  3AQC B;  4MC8 A;  5ERN A;  4H5C F;  4NG6 A;  1HM4 A;  4N9U A;  4NUA A;  4H5E F;  3KRC B;  3VJ9 A;  2F8C F;  3SDU A;  3AQ0 A;  4E9U A;  3EZ3 A;  1UBX A;  5AEL A;  3B7L A;  3TFP A;  2E94 A;  2Z4V A;  1HM7 A;  5E8L A;  1V4E A;  5JUZ F;  1JFG A;  1WMW A;  4KFA A;  2ZCO A;  4MC0 A;  1UBV A;  3DYG A;  5IK0 A;  3N6K F;  2Q9Z A;  1UBW A;  4LFV F;  5IK6 A;  2ONH A;  3ICK A;  4JVJ F;  3VJE A;  3WC9 A;  3N45 F;  3WSB A;  1WKZ A;  3N1W F;  3N3D A;  3RYE A;  4KVI A;  3KRF B;  5ILK A;  4GA3 A;  1HX9 A;  3LJI A;  2PS4 A;  3N3L F;  4XQS F;  4P0X A;  3WSA A;  3MZV A;  5DJV F;  4RNQ A;  3WCL A;  4P0W A;  2E8T A;  4GAX A;  4LXW A;  3OYR A;  4HD1 A;  5AYP A;  3KRO B;  1N23 A;  5IN8 A;  5KSX F;  3WEG A;  1V4H A;  5DJR F;  2ZCQ A;  2F89 F;  3V66 A;  2O1O A;  5E8H A;  3WCG A;  3WJN A;  3N46 F;  4LOB A;  5ILD A;  3KRC A;  2F7M F;  2AZJ A;  1VG7 A;  4LFG A;  5ERO A;  3ADZ A;  5CG6 A;  3CKE A;  5DGS F;  3ZMC A;  3TC1 A;  2PS8 A;  4DWB A;  3SDT A;  3LOM A;  3APZ A;  2Q80 A;  5ILI A;  2ZCS A;  4KVY A;  2Z4Z A;  4JZX A;  4RXC A;  3EGT A;  2E92 A;  3WEI A;  3LZ9 A;  3PKO A;  5DW7 A;  2J1O A;  2J5C A;  1VG4 A;  3KRF A;  3ZL6 A;  2PS5 A;  3V1X A;  3IPI A;  5EAT A;  2ZEV A;  4P0V A;  3OAB B;  4OKZ A;  1PS1 A;  5AFX A;  3ID0 A;  5E8K A;  3RYW A;  5B01 A;  4KKM A;  3Q1O A;  3M01 A;  3V1V A;  1YQ7 A;  3LG5 A;  5ER8 A;  3G4F A;  3KRO A;  3ASX A;  2H8O A;  3N0F A;  5CG5 A;  4LZC A;  3ACX A;  3P8L A;  5ILY A;  5HNA A;  4GP2 A;  4OKM A;  3KB9 A;  5JV1 F;  5IMP A;  1N22 A;  4LFE A;  4H5D F;  5IL3 A;  1RTR A;  1RQI A;  1WL0 A;  4E9Z A;  3KBK A;  4LIX A;  4LA5 A;  5EAU A;  2Z7I A;  3DYH A;  3KRA B;  4OMG A;  3WCC A;  3LVS A;  1HXG A;  1YYS A;  2E91 A;  4PVY F;  5B00 A;  5ILZ A;  2AZK A;  4DWG A;  3PYB A;  4XQR F;  3Q2Z A;  3LGK A;  4KVD A;  3Q30 A;  4NFJ F;  3SAE A;  4JZB A;  3WCM A;  5B0K A;  2ZCR A;  1RQJ A;  4KK2 A;  4RXD A;  4QPF A;  3CC9 A;  1HXC A;  1FPS A;  2Q58 A;  3ICN A;  2F94 F;  2P1C A;  3WJK A;  1HXA A;  3OAB A;  2FOR A;  3VJD A;  3NPR A;  4KVW A;  1V4K A;  3AQB B;  3M02 A;  1WL2 A;  3ACW A;  3M0G A;  3SDQ A;  5IMN A;  5IKA A;  4GP1 A;  2J1P A;  1UBY A;  3ACY A;  5HN7 A;  3VJC A;  5I1U A;  2Z7H A;  5JV2 F;  4LLT A;  3N1V F;  1YHK A;  1JFA A;  4E1E A;  1ZW5 A;  2PS6 A;  3P5P A;  3QQV A;  2ZEU A;  3S4J A;  5C05 A;  3WCF A;  1YV5 A;  3LEE A;  2Z52 A;  3KRA A;  2E90 A;  4LTV A;  5ILJ A;  5DJP F;  4NFI F;  5B0M A;  3WCI A;  3WCE A;  4LA6 A;  1YYR A;  5JV0 F;  2F92 F;  5JA0 F;  4DI5 A;  3ZMB A;  2ZY1 A;  4LPH F;  3WCH A;  3ZOU A;  4EA1 A;  3OAC B;  2E8X A;  4F62 A;  1N1B A;  2AEL A;  3SDV A;  2E4O A;  4RYP A;  2AZL A;  3LK5 A;  2E8V A;  4OMH A;  3M00 A;  4DHD A;  4DXJ A;  4OGU A;  2AET A;  3VJB A;  2F9K F;  3WEF A;  4LTZ A;  2EWG A;  5H9D A;  4KQU A;  3TS7 A;  2Q9Y A;  1V4I A; 
#chains in the Genus database with same CATH topology
 3BNX A;  3RMG A;  5DGN F;  3W7F A;  3N0G A;  3KRP A;  4FP4 A;  3PYA A;  2OA6 A;  3TFV A;  4KUX A;  3ICM A;  1VG6 A;  3WE9 A;  4KPD A;  3WJO A;  1WL1 A;  2PS7 A;  3N49 F;  3P5R A;  2FTZ A;  3WEH A;  2ONG A;  4KQS A;  5DIQ F;  3UCA A;  5A0I A;  3M9U A;  1KIY A;  3VJ8 A;  2VF6 A;  4Q23 A;  5B02 A;  1WY0 A;  5IMI A;  1YYU A;  2RAH A;  3P41 A;  4F6V A;  4L2X F;  3OAC A;  3WEK A;  3AE0 A;  4K10 A;  5HN8 A;  4N1Z F;  2Z78 A;  4JXY A;  5HN9 A;  5ERM A;  1KIZ A;  3NPK A;  4NFK F;  4LUU A;  5B03 A;  4PVX F;  3QKC A;  3WCB A;  1V4J A;  2OPM A;  4NKE A;  4ZQ8 A;  4DEM F;  2OGD A;  2E95 A;  3VJA A;  3LDW A;  5IM1 A;  1N20 A;  4DZW A;  5DHK A;  3PDE A;  3KRP B;  1N1Z A;  5DGM F;  3WCA A;  4QXS F;  3NRI A;  2I19 A;  3P8R A;  2Z4X A;  1DI1 A;  3WCJ A;  4MC3 A;  1N24 A;  1N21 A;  1YHL A;  3BNY A;  3TFN A;  1EZF A;  4LLS A;  4FJQ A;  4RXA A;  5B0J A;  4JYX A;  3N5H F;  4KQ5 A;  1YJ4 A;  2Z50 A;  1DGP A;  5IVG A;  4RXE A;  1VG3 A;  3MAV A;  4UMJ A;  3LSN A;  3S9V A;  3WCD A;  5DHI A;  5A0K A;  2DH4 A;  2E93 A;  2OPN A;  1VG2 A;  4XQT F;  5AHU B;  4LPG F;  1YYT A;  3LGZ B;  3CP6 A;  4F6X A;  1WL3 A;  4LZ3 A;  4EA2 A;  1YHM A;  5B0I A;  5EAS A;  3G4D A;  5IK9 A;  3IBA A;  4EA0 A;  3DYF A;  5B0L A;  4LZ0 A;  3WEJ A;  3Q2Q A;  2AEK A;  4WK5 A;  5IL8 A;  3NF2 A;  4NKF A;  5IKH A;  2Z4Y A;  2QIS A;  2E8W A;  3SDR A;  2Z4W A;  4KPJ A;  5A0J A;  3PH7 A;  3LMD A;  3ICZ A;  2E8U A;  2F8Z F;  3LLW A;  5ILH A;  3EFQ A;  3N5J F;  4KWD A;  3ZCD A;  4JXN A;  5DZ2 A;  1YYQ A;  3RBM A;  3AQC B;  4MC8 A;  5ERN A;  4H5C F;  4NG6 A;  1HM4 A;  4N9U A;  4NUA A;  4H5E F;  3KRC B;  3VJ9 A;  2F8C F;  3SDU A;  3AQ0 A;  4E9U A;  3EZ3 A;  1UBX A;  5AEL A;  3B7L A;  3TFP A;  2E94 A;  2Z4V A;  1HM7 A;  5E8L A;  1V4E A;  5JUZ F;  1JFG A;  1WMW A;  4KFA A;  2ZCO A;  4MC0 A;  1UBV A;  3DYG A;  5IK0 A;  3N6K F;  2Q9Z A;  1UBW A;  4LFV F;  5IK6 A;  2ONH A;  3ICK A;  4JVJ F;  3VJE A;  3WC9 A;  3N45 F;  3WSB A;  1WKZ A;  3N1W F;  3N3D A;  3RYE A;  4KVI A;  3KRF B;  5ILK A;  4GA3 A;  1HX9 A;  3LJI A;  2PS4 A;  3N3L F;  4XQS F;  4P0X A;  3WSA A;  3MZV A;  5DJV F;  4RNQ A;  3WCL A;  4P0W A;  2E8T A;  4GAX A;  4LXW A;  3OYR A;  4HD1 A;  5AYP A;  3KRO B;  1N23 A;  5IN8 A;  5KSX F;  3WEG A;  1V4H A;  5DJR F;  2ZCQ A;  2F89 F;  3V66 A;  2O1O A;  5E8H A;  3WCG A;  3WJN A;  3N46 F;  4LOB A;  5ILD A;  3KRC A;  2F7M F;  2AZJ A;  1VG7 A;  4LFG A;  5ERO A;  3ADZ A;  5CG6 A;  3CKE A;  5DGS F;  3ZMC A;  3TC1 A;  2PS8 A;  4DWB A;  3SDT A;  3LOM A;  3APZ A;  2Q80 A;  5ILI A;  2ZCS A;  4KVY A;  2Z4Z A;  4JZX A;  4RXC A;  3EGT A;  2E92 A;  3WEI A;  3LZ9 A;  3PKO A;  5DW7 A;  2J1O A;  2J5C A;  1VG4 A;  3KRF A;  3ZL6 A;  2PS5 A;  3V1X A;  3IPI A;  5EAT A;  2ZEV A;  4P0V A;  3OAB B;  4OKZ A;  1PS1 A;  5AFX A;  3ID0 A;  5E8K A;  3RYW A;  5B01 A;  4KKM A;  3Q1O A;  3M01 A;  3V1V A;  1YQ7 A;  3LG5 A;  5ER8 A;  3G4F A;  3KRO A;  3ASX A;  2H8O A;  3N0F A;  5CG5 A;  4LZC A;  3ACX A;  3P8L A;  5ILY A;  5HNA A;  4GP2 A;  4OKM A;  3KB9 A;  5JV1 F;  5IMP A;  1N22 A;  4LFE A;  4H5D F;  5IL3 A;  1RTR A;  1RQI A;  1WL0 A;  4E9Z A;  3KBK A;  4LIX A;  4LA5 A;  5EAU A;  2Z7I A;  3DYH A;  3KRA B;  4OMG A;  3WCC A;  3LVS A;  1HXG A;  1YYS A;  2E91 A;  4PVY F;  5B00 A;  5ILZ A;  2AZK A;  4DWG A;  3PYB A;  4XQR F;  3Q2Z A;  3LGK A;  4KVD A;  3Q30 A;  4NFJ F;  3SAE A;  4JZB A;  3WCM A;  5B0K A;  2ZCR A;  1RQJ A;  4KK2 A;  4RXD A;  4QPF A;  3CC9 A;  1HXC A;  1FPS A;  2Q58 A;  3ICN A;  2F94 F;  2P1C A;  3WJK A;  1HXA A;  3OAB A;  2FOR A;  3VJD A;  3NPR A;  4KVW A;  1V4K A;  3AQB B;  3M02 A;  1WL2 A;  3ACW A;  3M0G A;  3SDQ A;  5IMN A;  5IKA A;  4GP1 A;  2J1P A;  1UBY A;  3ACY A;  5HN7 A;  3VJC A;  5I1U A;  2Z7H A;  5JV2 F;  4LLT A;  3N1V F;  1YHK A;  1JFA A;  4E1E A;  1ZW5 A;  2PS6 A;  3P5P A;  3QQV A;  2ZEU A;  3S4J A;  5C05 A;  3WCF A;  1YV5 A;  3LEE A;  2Z52 A;  3KRA A;  2E90 A;  4LTV A;  5ILJ A;  5DJP F;  4NFI F;  5B0M A;  3WCI A;  3WCE A;  4LA6 A;  1YYR A;  5JV0 F;  2F92 F;  5JA0 F;  4DI5 A;  3ZMB A;  2ZY1 A;  4LPH F;  3WCH A;  3ZOU A;  4EA1 A;  3OAC B;  2E8X A;  4F62 A;  1N1B A;  2AEL A;  3SDV A;  2E4O A;  4RYP A;  2AZL A;  3LK5 A;  2E8V A;  4OMH A;  3M00 A;  4DHD A;  4DXJ A;  4OGU A;  2AET A;  3VJB A;  2F9K F;  3WEF A;  4LTZ A;  2EWG A;  5H9D A;  4KQU A;  3TS7 A;  2Q9Y A;  1V4I A; 
#chains in the Genus database with same CATH homology
 3BNX A;  3RMG A;  5DGN F;  3W7F A;  3N0G A;  3KRP A;  4FP4 A;  3PYA A;  2OA6 A;  3TFV A;  4KUX A;  3ICM A;  1VG6 A;  3WE9 A;  4KPD A;  3WJO A;  1WL1 A;  2PS7 A;  3N49 F;  3P5R A;  2FTZ A;  3WEH A;  2ONG A;  4KQS A;  5DIQ F;  3UCA A;  5A0I A;  3M9U A;  1KIY A;  3VJ8 A;  2VF6 A;  4Q23 A;  5B02 A;  1WY0 A;  5IMI A;  1YYU A;  2RAH A;  3P41 A;  4F6V A;  4L2X F;  3OAC A;  3WEK A;  3AE0 A;  4K10 A;  5HN8 A;  4N1Z F;  2Z78 A;  4JXY A;  5HN9 A;  5ERM A;  1KIZ A;  3NPK A;  4NFK F;  4LUU A;  5B03 A;  4PVX F;  3QKC A;  3WCB A;  1V4J A;  2OPM A;  4NKE A;  4ZQ8 A;  4DEM F;  2OGD A;  2E95 A;  3VJA A;  3LDW A;  5IM1 A;  1N20 A;  4DZW A;  5DHK A;  3PDE A;  3KRP B;  1N1Z A;  5DGM F;  3WCA A;  4QXS F;  3NRI A;  2I19 A;  3P8R A;  2Z4X A;  1DI1 A;  3WCJ A;  4MC3 A;  1N24 A;  1N21 A;  1YHL A;  3BNY A;  3TFN A;  1EZF A;  4LLS A;  4FJQ A;  4RXA A;  5B0J A;  4JYX A;  3N5H F;  4KQ5 A;  1YJ4 A;  2Z50 A;  1DGP A;  5IVG A;  4RXE A;  1VG3 A;  3MAV A;  4UMJ A;  3LSN A;  3S9V A;  3WCD A;  5DHI A;  5A0K A;  2DH4 A;  2E93 A;  2OPN A;  1VG2 A;  4XQT F;  5AHU B;  4LPG F;  1YYT A;  3LGZ B;  3CP6 A;  4F6X A;  1WL3 A;  4LZ3 A;  4EA2 A;  1YHM A;  5B0I A;  5EAS A;  3G4D A;  5IK9 A;  3IBA A;  4EA0 A;  3DYF A;  5B0L A;  4LZ0 A;  3WEJ A;  3Q2Q A;  2AEK A;  4WK5 A;  5IL8 A;  3NF2 A;  4NKF A;  5IKH A;  2Z4Y A;  2QIS A;  2E8W A;  3SDR A;  2Z4W A;  4KPJ A;  5A0J A;  3PH7 A;  3LMD A;  3ICZ A;  2E8U A;  2F8Z F;  3LLW A;  5ILH A;  3EFQ A;  3N5J F;  4KWD A;  3ZCD A;  4JXN A;  5DZ2 A;  1YYQ A;  3RBM A;  3AQC B;  4MC8 A;  5ERN A;  4H5C F;  4NG6 A;  1HM4 A;  4N9U A;  4NUA A;  4H5E F;  3KRC B;  3VJ9 A;  2F8C F;  3SDU A;  3AQ0 A;  4E9U A;  3EZ3 A;  1UBX A;  5AEL A;  3B7L A;  3TFP A;  2E94 A;  2Z4V A;  1HM7 A;  5E8L A;  1V4E A;  5JUZ F;  1JFG A;  1WMW A;  4KFA A;  2ZCO A;  4MC0 A;  1UBV A;  3DYG A;  5IK0 A;  3N6K F;  2Q9Z A;  1UBW A;  4LFV F;  5IK6 A;  2ONH A;  3ICK A;  4JVJ F;  3VJE A;  3WC9 A;  3N45 F;  3WSB A;  1WKZ A;  3N1W F;  3N3D A;  3RYE A;  4KVI A;  3KRF B;  5ILK A;  4GA3 A;  1HX9 A;  3LJI A;  2PS4 A;  3N3L F;  4XQS F;  4P0X A;  3WSA A;  3MZV A;  5DJV F;  4RNQ A;  3WCL A;  4P0W A;  2E8T A;  4GAX A;  4LXW A;  3OYR A;  4HD1 A;  5AYP A;  3KRO B;  1N23 A;  5IN8 A;  5KSX F;  3WEG A;  1V4H A;  5DJR F;  2ZCQ A;  2F89 F;  3V66 A;  2O1O A;  5E8H A;  3WCG A;  3WJN A;  3N46 F;  4LOB A;  5ILD A;  3KRC A;  2F7M F;  2AZJ A;  1VG7 A;  4LFG A;  5ERO A;  3ADZ A;  5CG6 A;  3CKE A;  5DGS F;  3ZMC A;  3TC1 A;  2PS8 A;  4DWB A;  3SDT A;  3LOM A;  3APZ A;  2Q80 A;  5ILI A;  2ZCS A;  4KVY A;  2Z4Z A;  4JZX A;  4RXC A;  3EGT A;  2E92 A;  3WEI A;  3LZ9 A;  3PKO A;  5DW7 A;  2J1O A;  2J5C A;  1VG4 A;  3KRF A;  3ZL6 A;  2PS5 A;  3V1X A;  3IPI A;  5EAT A;  2ZEV A;  4P0V A;  3OAB B;  4OKZ A;  1PS1 A;  5AFX A;  3ID0 A;  5E8K A;  3RYW A;  5B01 A;  4KKM A;  3Q1O A;  3M01 A;  3V1V A;  1YQ7 A;  3LG5 A;  5ER8 A;  3G4F A;  3KRO A;  3ASX A;  2H8O A;  3N0F A;  5CG5 A;  4LZC A;  3ACX A;  3P8L A;  5ILY A;  5HNA A;  4GP2 A;  4OKM A;  3KB9 A;  5JV1 F;  5IMP A;  1N22 A;  4LFE A;  4H5D F;  5IL3 A;  1RTR A;  1RQI A;  1WL0 A;  4E9Z A;  3KBK A;  4LIX A;  4LA5 A;  5EAU A;  2Z7I A;  3DYH A;  3KRA B;  4OMG A;  3WCC A;  3LVS A;  1HXG A;  1YYS A;  2E91 A;  4PVY F;  5B00 A;  5ILZ A;  2AZK A;  4DWG A;  3PYB A;  4XQR F;  3Q2Z A;  3LGK A;  4KVD A;  3Q30 A;  4NFJ F;  3SAE A;  4JZB A;  3WCM A;  5B0K A;  2ZCR A;  1RQJ A;  4KK2 A;  4RXD A;  4QPF A;  3CC9 A;  1HXC A;  1FPS A;  2Q58 A;  3ICN A;  2F94 F;  2P1C A;  3WJK A;  1HXA A;  3OAB A;  2FOR A;  3VJD A;  3NPR A;  4KVW A;  1V4K A;  3AQB B;  3M02 A;  1WL2 A;  3ACW A;  3M0G A;  3SDQ A;  5IMN A;  5IKA A;  4GP1 A;  2J1P A;  1UBY A;  3ACY A;  5HN7 A;  3VJC A;  5I1U A;  2Z7H A;  5JV2 F;  4LLT A;  3N1V F;  1YHK A;  1JFA A;  4E1E A;  1ZW5 A;  2PS6 A;  3P5P A;  3QQV A;  2ZEU A;  3S4J A;  5C05 A;  3WCF A;  1YV5 A;  3LEE A;  2Z52 A;  3KRA A;  2E90 A;  4LTV A;  5ILJ A;  5DJP F;  4NFI F;  5B0M A;  3WCI A;  3WCE A;  4LA6 A;  1YYR A;  5JV0 F;  2F92 F;  5JA0 F;  4DI5 A;  3ZMB A;  2ZY1 A;  4LPH F;  3WCH A;  3ZOU A;  4EA1 A;  3OAC B;  2E8X A;  4F62 A;  1N1B A;  2AEL A;  3SDV A;  2E4O A;  4RYP A;  2AZL A;  3LK5 A;  2E8V A;  4OMH A;  3M00 A;  4DHD A;  4DXJ A;  4OGU A;  2AET A;  3VJB A;  2F9K F;  3WEF A;  4LTZ A;  2EWG A;  5H9D A;  4KQU A;  3TS7 A;  2Q9Y A;  1V4I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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