4NG6A

The effects of lysine 200 and phenylalanine 239 farnesyl pyrophosphate synthase (fpps) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Total Genus 131
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
344
structure length
344
Chain Sequence
YAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYLTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords Farnesyl pyrophosphate synthase
publication title The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
rcsb
source organism Homo sapiens
total genus 131
structure length 344
sequence length 344
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4ng6A00
3S9VA 1YYQA 3P5PA 3APZA 3N5HF 1RQJA 1DGPA 1YHKA 3WCIA 2FTZA 3LMDA 1WY0A 3N1WF 5HN7A 4LZCA 2ZEVA 3P41A 5ILJA 3LSNA 3KB9A 1RTRA 4QXSF 5AFXA 5JA0F 1PS1A 3ZL6A 2FORA 3SDQA 4NKFA 2ZCOA 3N0GA 3V66A 4LPGF 5KSXF 3ID0A 2J1PA 3N1VF 4XQSF 1V4IA 3WCLA 1VG4A 3N45F 3DYFA 3LG5A 4OKZA 4KFAA 3WJOA 1YV5A 3LDWA 1WL1A 1N20A 4KKMA 5ILKA 1YHMA 4MC0A 2E91A 3MAVA 2F94F 3OYRA 3Q2ZA 4KVDA 4Q23A 4ZQ8A 1FPSA 1UBWA 1HM7A 4NFIF 5B0IA 3VJAA 4LZ0A 4OMHA 3M9UA 2QISA 5JV1F 2AETA 4OGUA 3LVSA 5B03A 3ICKA 4F62A 2E93A 5B0MA 5IVGA 3PYAA 4RNQA 3N6KF 3NF2A 3WEHA 2O1OA 1N1BA 3ACYA 5IKHA 3V1XA 5ERMA 4EA2A 3KRFA 3RYEA 3TFPA 2E8TA 5ILDA 4JYXA 1YHLA 4KUXA 2J1OA 3LJIA 2Z7IA 5DGNF 3WCEA 3TFVA 4NUAA 4DI5A 5CG5A 2AELA 4EA1A 5HNAA 4F6XA 5DW7A 3KROB 1N1ZA 4KQSA 3B7LA 3TFNA 4RXDA 1WMWA 5IMPA 1V4EA 3DYHA 4LLSA 5IK0A 5ILYA 1VG7A 1YYRA 4N9UA 3WEIA 4LIXA 3SAEA 3WCCA 4LXWA 3DYGA 3OABA 3KROA 4GP1A 1V4HA 5IK6A 1V4KA 5IL3A 1WKZA 4LTVA 3PYBA 3AQCB 1WL3A 4P0XA 1ZW5A 1YYSA 1YQ7A 4KPJA 4UMJA 3WCJA 3LOMA 2VF6A 2ZCSA 2AEKA 2F8CF 5DZ2A 1WL2A 5AELA 1V4JA 5JUZF 3EGTA 2PS8A 4RYPA 4DEMF 5JV0F 3KRAB 3WCBA 3ADZA 3OACB 3ACXA 3WJNA 2Q9ZA 1VG2A 3SDRA 1EZFA 5DJVF 3Q1OA 4XQRF 5EASA 5IN8A 3WJKA 4GP2A 3KBKA 3WCAA 2ZCRA 3VJDA 4FJQA 4P0VA 3TS7A 1YJ4A 2E8UA 3EZ3A 3IPIA 3OACA 2ZEUA 3AQBB 4KVIA 3LGKA 3N49F 5B0JA 3KRCB 5I1UA 3ACWA 4DXJA 3ICNA 2E8XA 1UBYA 5ER8A 3VJ9A 2Q58A 3WC9A 3N5JF 2E4OA 5ILZA 5DJRF 3BNXA 3M01A 3PH7A 4PVXF 3G4DA 1HM4A 2E94A 3UCAA 2ZCQA 2F8ZF 3M02A 3ASXA 5EAUA 3SDTA 4JVJF 3WSAA 2PS4A 3MZVA 3LK5A 4LLTA 4LPHF 4KPDA 3M00A 1UBXA 4DWBA 4E9ZA 4JZXA 1RQIA 4NKEA 3M0GA 5B01A 4HD1A 5JV2F 5ILHA 1YYUA 2Z78A 4LFGA 2PS6A 3N0FA 5CG6A 4DWGA 5IKAA 3VJCA 3WE9A 3CP6A 2H8OA 4F6VA 4K10A 3G4FA 4RXEA 5B02A 4DZWA 5E8LA 5B0LA 5IL8A 1KIYA 3WEJA 3WSBA 5DHIA 5EROA 2Z4VA 3KRPB 1WL0A 2AZLA 3Q2QA 2OPNA 4RXAA 2F92F 4FP4A 3P8LA 5IK9A 5ILIA 1HXCA 4MC3A 4L2XF 2ONHA 3ZOUA 3VJ8A 3PKOA 3N3LF 3ZMBA 3WCDA 4QPFA 5DIQF 4LA5A 4KQUA 2DH4A 3CC9A 3AQ0A 2EWGA 4MC8A 2E95A 2J5CA 4LTZA 2ONGA 2F9KF 4JXNA 1HXGA 3LZ9A 5DGSF 3RYWA 3WEFA 1DI1A 2PS7A 4GAXA 5A0JA 1JFAA 4OKMA 3WCFA 5C05A 3W7FA 3N3DA 4H5EF 2E8WA 2OA6A 3WCHA 5DHKA 1JFGA 5A0KA 3V1VA 4JZBA 4H5DF 4KVYA 2Z4YA 3KRAA 1HXAA 2Z4XA 4LOBA 2Z4WA 4JXYA 4P0WA 5E8KA 4N1ZF 4DHDA 2Z52A 4OMGA 3SDVA 3NPKA 3QKCA 4WK5A 4NFJF 2F7MF 3IBAA 3LGZB 4PVYF 4KWDA 3VJBA 1N21A 2OGDA 3RMGA 4KQ5A 3KRCA 2E90A 2ZY1A 4NG6A 2Q9YA 3ZMCA 3CKEA 5DGMF 5AHUB 2Z50A 3ICZA 5EATA 3KRFB 4KK2A 5AYPA 3ICMA 5IMNA 5B00A 3WCGA 3WEGA 1UBVA 5ERNA 3LEEA 2P1CA 4E9UA 1HX9A 3SDUA 3LLWA 4E1EA 2E92A 5HN8A 3S4JA 3ZCDA 2Z4ZA 2I19A 4H5CF 3NRIA 1KIZA 2AZJA 3QQVA 2AZKA 3AE0A 5H9DA 2Z7HA 3EFQA 1N22A 4LA6A 3WCMA 5IM1A 2Q80A 3Q30A 1VG3A 2OPMA 4KVWA 5A0IA 3N46F 4LFVF 3BNYA 5B0KA 1VG6A 2E8VA 2F89F 4GA3A 2PS5A 1YYTA 3P8RA 4XQTF 4RXCA 3OABB 3KRPA 3TC1A 1N24A 4EA0A 3PDEA 5DJPF 3NPRA 5IMIA 3WEKA 4LZ3A 5HN9A 4LUUA 3VJEA 3P5RA 4LFEA 4NFKF 5E8HA 1N23A 2RAHA 3RBMA
chains in the Genus database with same CATH superfamily
3S9VA 1YYQA 3P5PA 3APZA 3N5HF 1RQJA 1DGPA 1YHKA 3WCIA 2FTZA 3LMDA 1WY0A 3N1WF 5HN7A 4LZCA 2ZEVA 3P41A 5ILJA 3LSNA 3KB9A 1RTRA 4QXSF 5AFXA 5JA0F 1PS1A 3ZL6A 2FORA 3SDQA 4NKFA 2ZCOA 3N0GA 3V66A 4LPGF 5KSXF 3ID0A 2J1PA 3N1VF 4XQSF 1V4IA 3WCLA 1VG4A 3N45F 3DYFA 3LG5A 4OKZA 4KFAA 3WJOA 1YV5A 3LDWA 1WL1A 1N20A 4KKMA 5ILKA 1YHMA 4MC0A 2E91A 3MAVA 2F94F 3OYRA 3Q2ZA 4KVDA 4Q23A 4ZQ8A 1FPSA 1UBWA 1HM7A 4NFIF 5B0IA 3VJAA 4LZ0A 4OMHA 3M9UA 2QISA 5JV1F 2AETA 4OGUA 3LVSA 5B03A 3ICKA 4F62A 2E93A 5B0MA 5IVGA 3PYAA 4RNQA 3N6KF 3NF2A 3WEHA 2O1OA 1N1BA 3ACYA 5IKHA 3V1XA 5ERMA 4EA2A 3KRFA 3RYEA 3TFPA 2E8TA 5ILDA 4JYXA 1YHLA 4KUXA 2J1OA 3LJIA 2Z7IA 5DGNF 3WCEA 3TFVA 4NUAA 4DI5A 5CG5A 2AELA 4EA1A 5HNAA 4F6XA 5DW7A 3KROB 1N1ZA 4KQSA 3B7LA 3TFNA 4RXDA 1WMWA 5IMPA 1V4EA 3DYHA 4LLSA 5IK0A 5ILYA 1VG7A 1YYRA 4N9UA 3WEIA 4LIXA 3SAEA 3WCCA 4LXWA 3DYGA 3OABA 3KROA 4GP1A 1V4HA 5IK6A 1V4KA 5IL3A 1WKZA 4LTVA 3PYBA 3AQCB 1WL3A 4P0XA 1ZW5A 1YYSA 1YQ7A 4KPJA 4UMJA 3WCJA 3LOMA 2VF6A 2ZCSA 2AEKA 2F8CF 5DZ2A 1WL2A 5AELA 1V4JA 5JUZF 3EGTA 2PS8A 4RYPA 4DEMF 5JV0F 3KRAB 3WCBA 3ADZA 3OACB 3ACXA 3WJNA 2Q9ZA 1VG2A 3SDRA 1EZFA 5DJVF 3Q1OA 4XQRF 5EASA 5IN8A 3WJKA 4GP2A 3KBKA 3WCAA 2ZCRA 3VJDA 4FJQA 4P0VA 3TS7A 1YJ4A 2E8UA 3EZ3A 3IPIA 3OACA 2ZEUA 3AQBB 4KVIA 3LGKA 3N49F 5B0JA 3KRCB 5I1UA 3ACWA 4DXJA 3ICNA 2E8XA 1UBYA 5ER8A 3VJ9A 2Q58A 3WC9A 3N5JF 2E4OA 5ILZA 5DJRF 3BNXA 3M01A 3PH7A 4PVXF 3G4DA 1HM4A 2E94A 3UCAA 2ZCQA 2F8ZF 3M02A 3ASXA 5EAUA 3SDTA 4JVJF 3WSAA 2PS4A 3MZVA 3LK5A 4LLTA 4LPHF 4KPDA 3M00A 1UBXA 4DWBA 4E9ZA 4JZXA 1RQIA 4NKEA 3M0GA 5B01A 4HD1A 5JV2F 5ILHA 1YYUA 2Z78A 4LFGA 2PS6A 3N0FA 5CG6A 4DWGA 5IKAA 3VJCA 3WE9A 3CP6A 2H8OA 4F6VA 4K10A 3G4FA 4RXEA 5B02A 4DZWA 5E8LA 5B0LA 5IL8A 1KIYA 3WEJA 3WSBA 5DHIA 5EROA 2Z4VA 3KRPB 1WL0A 2AZLA 3Q2QA 2OPNA 4RXAA 2F92F 4FP4A 3P8LA 5IK9A 5ILIA 1HXCA 4MC3A 4L2XF 2ONHA 3ZOUA 3VJ8A 3PKOA 3N3LF 3ZMBA 3WCDA 4QPFA 5DIQF 4LA5A 4KQUA 2DH4A 3CC9A 3AQ0A 2EWGA 4MC8A 2E95A 2J5CA 4LTZA 2ONGA 2F9KF 4JXNA 1HXGA 3LZ9A 5DGSF 3RYWA 3WEFA 1DI1A 2PS7A 4GAXA 5A0JA 1JFAA 4OKMA 3WCFA 5C05A 3W7FA 3N3DA 4H5EF 2E8WA 2OA6A 3WCHA 5DHKA 1JFGA 5A0KA 3V1VA 4JZBA 4H5DF 4KVYA 2Z4YA 3KRAA 1HXAA 2Z4XA 4LOBA 2Z4WA 4JXYA 4P0WA 5E8KA 4N1ZF 4DHDA 2Z52A 4OMGA 3SDVA 3NPKA 3QKCA 4WK5A 4NFJF 2F7MF 3IBAA 3LGZB 4PVYF 4KWDA 3VJBA 1N21A 2OGDA 3RMGA 4KQ5A 3KRCA 2E90A 2ZY1A 4NG6A 2Q9YA 3ZMCA 3CKEA 5DGMF 5AHUB 2Z50A 3ICZA 5EATA 3KRFB 4KK2A 5AYPA 3ICMA 5IMNA 5B00A 3WCGA 3WEGA 1UBVA 5ERNA 3LEEA 2P1CA 4E9UA 1HX9A 3SDUA 3LLWA 4E1EA 2E92A 5HN8A 3S4JA 3ZCDA 2Z4ZA 2I19A 4H5CF 3NRIA 1KIZA 2AZJA 3QQVA 2AZKA 3AE0A 5H9DA 2Z7HA 3EFQA 1N22A 4LA6A 3WCMA 5IM1A 2Q80A 3Q30A 1VG3A 2OPMA 4KVWA 5A0IA 3N46F 4LFVF 3BNYA 5B0KA 1VG6A 2E8VA 2F89F 4GA3A 2PS5A 1YYTA 3P8RA 4XQTF 4RXCA 3OABB 3KRPA 3TC1A 1N24A 4EA0A 3PDEA 5DJPF 3NPRA 5IMIA 3WEKA 4LZ3A 5HN9A 4LUUA 3VJEA 3P5RA 4LFEA 4NFKF 5E8HA 1N23A 2RAHA 3RBMA
chains in the Genus database with same CATH topology
3S9VA 1YYQA 3P5PA 3APZA 3N5HF 1RQJA 1DGPA 1YHKA 3WCIA 2FTZA 3LMDA 1WY0A 3N1WF 5HN7A 4LZCA 2ZEVA 3P41A 5ILJA 3LSNA 3KB9A 1RTRA 4QXSF 5AFXA 5JA0F 1PS1A 3ZL6A 2FORA 3SDQA 4NKFA 2ZCOA 3N0GA 3V66A 4LPGF 5KSXF 3ID0A 2J1PA 3N1VF 4XQSF 1V4IA 3WCLA 1VG4A 3N45F 3DYFA 3LG5A 4OKZA 4KFAA 3WJOA 1YV5A 3LDWA 1WL1A 1N20A 4KKMA 5ILKA 1YHMA 4MC0A 2E91A 3MAVA 2F94F 3OYRA 3Q2ZA 4KVDA 4Q23A 4ZQ8A 1FPSA 1UBWA 1HM7A 4NFIF 5B0IA 3VJAA 4LZ0A 4OMHA 3M9UA 2QISA 5JV1F 2AETA 4OGUA 3LVSA 5B03A 3ICKA 4F62A 2E93A 5B0MA 5IVGA 3PYAA 4RNQA 3N6KF 3NF2A 3WEHA 2O1OA 1N1BA 3ACYA 5IKHA 3V1XA 5ERMA 4EA2A 3KRFA 3RYEA 3TFPA 2E8TA 5ILDA 4JYXA 1YHLA 4KUXA 2J1OA 3LJIA 2Z7IA 5DGNF 3WCEA 3TFVA 4NUAA 4DI5A 5CG5A 2AELA 4EA1A 5HNAA 4F6XA 5DW7A 3KROB 1N1ZA 4KQSA 3B7LA 3TFNA 4RXDA 1WMWA 5IMPA 1V4EA 3DYHA 4LLSA 5IK0A 5ILYA 1VG7A 1YYRA 4N9UA 3WEIA 4LIXA 3SAEA 3WCCA 4LXWA 3DYGA 3OABA 3KROA 4GP1A 1V4HA 5IK6A 1V4KA 5IL3A 1WKZA 4LTVA 3PYBA 3AQCB 1WL3A 4P0XA 1ZW5A 1YYSA 1YQ7A 4KPJA 4UMJA 3WCJA 3LOMA 2VF6A 2ZCSA 2AEKA 2F8CF 5DZ2A 1WL2A 5AELA 1V4JA 5JUZF 3EGTA 2PS8A 4RYPA 4DEMF 5JV0F 3KRAB 3WCBA 3ADZA 3OACB 3ACXA 3WJNA 2Q9ZA 1VG2A 3SDRA 1EZFA 5DJVF 3Q1OA 4XQRF 5EASA 5IN8A 3WJKA 4GP2A 3KBKA 3WCAA 2ZCRA 3VJDA 4FJQA 4P0VA 3TS7A 1YJ4A 2E8UA 3EZ3A 3IPIA 3OACA 2ZEUA 3AQBB 4KVIA 3LGKA 3N49F 5B0JA 3KRCB 5I1UA 3ACWA 4DXJA 3ICNA 2E8XA 1UBYA 5ER8A 3VJ9A 2Q58A 3WC9A 3N5JF 2E4OA 5ILZA 5DJRF 3BNXA 3M01A 3PH7A 4PVXF 3G4DA 1HM4A 2E94A 3UCAA 2ZCQA 2F8ZF 3M02A 3ASXA 5EAUA 3SDTA 4JVJF 3WSAA 2PS4A 3MZVA 3LK5A 4LLTA 4LPHF 4KPDA 3M00A 1UBXA 4DWBA 4E9ZA 4JZXA 1RQIA 4NKEA 3M0GA 5B01A 4HD1A 5JV2F 5ILHA 1YYUA 2Z78A 4LFGA 2PS6A 3N0FA 5CG6A 4DWGA 5IKAA 3VJCA 3WE9A 3CP6A 2H8OA 4F6VA 4K10A 3G4FA 4RXEA 5B02A 4DZWA 5E8LA 5B0LA 5IL8A 1KIYA 3WEJA 3WSBA 5DHIA 5EROA 2Z4VA 3KRPB 1WL0A 2AZLA 3Q2QA 2OPNA 4RXAA 2F92F 4FP4A 3P8LA 5IK9A 5ILIA 1HXCA 4MC3A 4L2XF 2ONHA 3ZOUA 3VJ8A 3PKOA 3N3LF 3ZMBA 3WCDA 4QPFA 5DIQF 4LA5A 4KQUA 2DH4A 3CC9A 3AQ0A 2EWGA 4MC8A 2E95A 2J5CA 4LTZA 2ONGA 2F9KF 4JXNA 1HXGA 3LZ9A 5DGSF 3RYWA 3WEFA 1DI1A 2PS7A 4GAXA 5A0JA 1JFAA 4OKMA 3WCFA 5C05A 3W7FA 3N3DA 4H5EF 2E8WA 2OA6A 3WCHA 5DHKA 1JFGA 5A0KA 3V1VA 4JZBA 4H5DF 4KVYA 2Z4YA 3KRAA 1HXAA 2Z4XA 4LOBA 2Z4WA 4JXYA 4P0WA 5E8KA 4N1ZF 4DHDA 2Z52A 4OMGA 3SDVA 3NPKA 3QKCA 4WK5A 4NFJF 2F7MF 3IBAA 3LGZB 4PVYF 4KWDA 3VJBA 1N21A 2OGDA 3RMGA 4KQ5A 3KRCA 2E90A 2ZY1A 4NG6A 2Q9YA 3ZMCA 3CKEA 5DGMF 5AHUB 2Z50A 3ICZA 5EATA 3KRFB 4KK2A 5AYPA 3ICMA 5IMNA 5B00A 3WCGA 3WEGA 1UBVA 5ERNA 3LEEA 2P1CA 4E9UA 1HX9A 3SDUA 3LLWA 4E1EA 2E92A 5HN8A 3S4JA 3ZCDA 2Z4ZA 2I19A 4H5CF 3NRIA 1KIZA 2AZJA 3QQVA 2AZKA 3AE0A 5H9DA 2Z7HA 3EFQA 1N22A 4LA6A 3WCMA 5IM1A 2Q80A 3Q30A 1VG3A 2OPMA 4KVWA 5A0IA 3N46F 4LFVF 3BNYA 5B0KA 1VG6A 2E8VA 2F89F 4GA3A 2PS5A 1YYTA 3P8RA 4XQTF 4RXCA 3OABB 3KRPA 3TC1A 1N24A 4EA0A 3PDEA 5DJPF 3NPRA 5IMIA 3WEKA 4LZ3A 5HN9A 4LUUA 3VJEA 3P5RA 4LFEA 4NFKF 5E8HA 1N23A 2RAHA 3RBMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S9V A;  1YYQ A;  3P5P A;  3APZ A;  3N5H F;  1RQJ A;  1DGP A;  1YHK A;  3WCI A;  2FTZ A;  3LMD A;  1WY0 A;  3N1W F;  5HN7 A;  4LZC A;  2ZEV A;  3P41 A;  5ILJ A;  3LSN A;  3KB9 A;  1RTR A;  4QXS F;  5AFX A;  5JA0 F;  1PS1 A;  3ZL6 A;  2FOR A;  3SDQ A;  4NKF A;  2ZCO A;  3N0G A;  3V66 A;  4LPG F;  5KSX F;  3ID0 A;  2J1P A;  3N1V F;  4XQS F;  1V4I A;  3WCL A;  1VG4 A;  3N45 F;  3DYF A;  3LG5 A;  4OKZ A;  4KFA A;  3WJO A;  1YV5 A;  3LDW A;  1WL1 A;  1N20 A;  4KKM A;  5ILK A;  1YHM A;  4MC0 A;  2E91 A;  3MAV A;  2F94 F;  3OYR A;  3Q2Z A;  4KVD A;  4Q23 A;  4ZQ8 A;  1FPS A;  1UBW A;  1HM7 A;  4NFI F;  5B0I A;  3VJA A;  4LZ0 A;  4OMH A;  3M9U A;  2QIS A;  5JV1 F;  2AET A;  4OGU A;  3LVS A;  5B03 A;  3ICK A;  4F62 A;  2E93 A;  5B0M A;  5IVG A;  3PYA A;  4RNQ A;  3N6K F;  3NF2 A;  3WEH A;  2O1O A;  1N1B A;  3ACY A;  5IKH A;  3V1X A;  5ERM A;  4EA2 A;  3KRF A;  3RYE A;  3TFP A;  2E8T A;  5ILD A;  4JYX A;  1YHL A;  4KUX A;  2J1O A;  3LJI A;  2Z7I A;  5DGN F;  3WCE A;  3TFV A;  4NUA A;  4DI5 A;  5CG5 A;  2AEL A;  4EA1 A;  5HNA A;  4F6X A;  5DW7 A;  3KRO B;  1N1Z A;  4KQS A;  3B7L A;  3TFN A;  4RXD A;  1WMW A;  5IMP A;  1V4E A;  3DYH A;  4LLS A;  5IK0 A;  5ILY A;  1VG7 A;  1YYR A;  4N9U A;  3WEI A;  4LIX A;  3SAE A;  3WCC A;  4LXW A;  3DYG A;  3OAB A;  3KRO A;  4GP1 A;  1V4H A;  5IK6 A;  1V4K A;  5IL3 A;  1WKZ A;  4LTV A;  3PYB A;  3AQC B;  1WL3 A;  4P0X A;  1ZW5 A;  1YYS A;  1YQ7 A;  4KPJ A;  4UMJ A;  3WCJ A;  3LOM A;  2VF6 A;  2ZCS A;  2AEK A;  2F8C F;  5DZ2 A;  1WL2 A;  5AEL A;  1V4J A;  5JUZ F;  3EGT A;  2PS8 A;  4RYP A;  4DEM F;  5JV0 F;  3KRA B;  3WCB A;  3ADZ A;  3OAC B;  3ACX A;  3WJN A;  2Q9Z A;  1VG2 A;  3SDR A;  1EZF A;  5DJV F;  3Q1O A;  4XQR F;  5EAS A;  5IN8 A;  3WJK A;  4GP2 A;  3KBK A;  3WCA A;  2ZCR A;  3VJD A;  4FJQ A;  4P0V A;  3TS7 A;  1YJ4 A;  2E8U A;  3EZ3 A;  3IPI A;  3OAC A;  2ZEU A;  3AQB B;  4KVI A;  3LGK A;  3N49 F;  5B0J A;  3KRC B;  5I1U A;  3ACW A;  4DXJ A;  3ICN A;  2E8X A;  1UBY A;  5ER8 A;  3VJ9 A;  2Q58 A;  3WC9 A;  3N5J F;  2E4O A;  5ILZ A;  5DJR F;  3BNX A;  3M01 A;  3PH7 A;  4PVX F;  3G4D A;  1HM4 A;  2E94 A;  3UCA A;  2ZCQ A;  2F8Z F;  3M02 A;  3ASX A;  5EAU A;  3SDT A;  4JVJ F;  3WSA A;  2PS4 A;  3MZV A;  3LK5 A;  4LLT A;  4LPH F;  4KPD A;  3M00 A;  1UBX A;  4DWB A;  4E9Z A;  4JZX A;  1RQI A;  4NKE A;  3M0G A;  5B01 A;  4HD1 A;  5JV2 F;  5ILH A;  1YYU A;  2Z78 A;  4LFG A;  2PS6 A;  3N0F A;  5CG6 A;  4DWG A;  5IKA A;  3VJC A;  3WE9 A;  3CP6 A;  2H8O A;  4F6V A;  4K10 A;  3G4F A;  4RXE A;  5B02 A;  4DZW A;  5E8L A;  5B0L A;  5IL8 A;  1KIY A;  3WEJ A;  3WSB A;  5DHI A;  5ERO A;  2Z4V A;  3KRP B;  1WL0 A;  2AZL A;  3Q2Q A;  2OPN A;  4RXA A;  2F92 F;  4FP4 A;  3P8L A;  5IK9 A;  5ILI A;  1HXC A;  4MC3 A;  4L2X F;  2ONH A;  3ZOU A;  3VJ8 A;  3PKO A;  3N3L F;  3ZMB A;  3WCD A;  4QPF A;  5DIQ F;  4LA5 A;  4KQU A;  2DH4 A;  3CC9 A;  3AQ0 A;  2EWG A;  4MC8 A;  2E95 A;  2J5C A;  4LTZ A;  2ONG A;  2F9K F;  4JXN A;  1HXG A;  3LZ9 A;  5DGS F;  3RYW A;  3WEF A;  1DI1 A;  2PS7 A;  4GAX A;  5A0J A;  1JFA A;  4OKM A;  3WCF A;  5C05 A;  3W7F A;  3N3D A;  4H5E F;  2E8W A;  2OA6 A;  3WCH A;  5DHK A;  1JFG A;  5A0K A;  3V1V A;  4JZB A;  4H5D F;  4KVY A;  2Z4Y A;  3KRA A;  1HXA A;  2Z4X A;  4LOB A;  2Z4W A;  4JXY A;  4P0W A;  5E8K A;  4N1Z F;  4DHD A;  2Z52 A;  4OMG A;  3SDV A;  3NPK A;  3QKC A;  4WK5 A;  4NFJ F;  2F7M F;  3IBA A;  3LGZ B;  4PVY F;  4KWD A;  3VJB A;  1N21 A;  2OGD A;  3RMG A;  4KQ5 A;  3KRC A;  2E90 A;  2ZY1 A;  4NG6 A;  2Q9Y A;  3ZMC A;  3CKE A;  5DGM F;  5AHU B;  2Z50 A;  3ICZ A;  5EAT A;  3KRF B;  4KK2 A;  5AYP A;  3ICM A;  5IMN A;  5B00 A;  3WCG A;  3WEG A;  1UBV A;  5ERN A;  3LEE A;  2P1C A;  4E9U A;  1HX9 A;  3SDU A;  3LLW A;  4E1E A;  2E92 A;  5HN8 A;  3S4J A;  3ZCD A;  2Z4Z A;  2I19 A;  4H5C F;  3NRI A;  1KIZ A;  2AZJ A;  3QQV A;  2AZK A;  3AE0 A;  5H9D A;  2Z7H A;  3EFQ A;  1N22 A;  4LA6 A;  3WCM A;  5IM1 A;  2Q80 A;  3Q30 A;  1VG3 A;  2OPM A;  4KVW A;  5A0I A;  3N46 F;  4LFV F;  3BNY A;  5B0K A;  1VG6 A;  2E8V A;  2F89 F;  4GA3 A;  2PS5 A;  1YYT A;  3P8R A;  4XQT F;  4RXC A;  3OAB B;  3KRP A;  3TC1 A;  1N24 A;  4EA0 A;  3PDE A;  5DJP F;  3NPR A;  5IMI A;  3WEK A;  4LZ3 A;  5HN9 A;  4LUU A;  3VJE A;  3P5R A;  4LFE A;  4NFK F;  5E8H A;  1N23 A;  2RAH A;  3RBM A; 
#chains in the Genus database with same CATH topology
 3S9V A;  1YYQ A;  3P5P A;  3APZ A;  3N5H F;  1RQJ A;  1DGP A;  1YHK A;  3WCI A;  2FTZ A;  3LMD A;  1WY0 A;  3N1W F;  5HN7 A;  4LZC A;  2ZEV A;  3P41 A;  5ILJ A;  3LSN A;  3KB9 A;  1RTR A;  4QXS F;  5AFX A;  5JA0 F;  1PS1 A;  3ZL6 A;  2FOR A;  3SDQ A;  4NKF A;  2ZCO A;  3N0G A;  3V66 A;  4LPG F;  5KSX F;  3ID0 A;  2J1P A;  3N1V F;  4XQS F;  1V4I A;  3WCL A;  1VG4 A;  3N45 F;  3DYF A;  3LG5 A;  4OKZ A;  4KFA A;  3WJO A;  1YV5 A;  3LDW A;  1WL1 A;  1N20 A;  4KKM A;  5ILK A;  1YHM A;  4MC0 A;  2E91 A;  3MAV A;  2F94 F;  3OYR A;  3Q2Z A;  4KVD A;  4Q23 A;  4ZQ8 A;  1FPS A;  1UBW A;  1HM7 A;  4NFI F;  5B0I A;  3VJA A;  4LZ0 A;  4OMH A;  3M9U A;  2QIS A;  5JV1 F;  2AET A;  4OGU A;  3LVS A;  5B03 A;  3ICK A;  4F62 A;  2E93 A;  5B0M A;  5IVG A;  3PYA A;  4RNQ A;  3N6K F;  3NF2 A;  3WEH A;  2O1O A;  1N1B A;  3ACY A;  5IKH A;  3V1X A;  5ERM A;  4EA2 A;  3KRF A;  3RYE A;  3TFP A;  2E8T A;  5ILD A;  4JYX A;  1YHL A;  4KUX A;  2J1O A;  3LJI A;  2Z7I A;  5DGN F;  3WCE A;  3TFV A;  4NUA A;  4DI5 A;  5CG5 A;  2AEL A;  4EA1 A;  5HNA A;  4F6X A;  5DW7 A;  3KRO B;  1N1Z A;  4KQS A;  3B7L A;  3TFN A;  4RXD A;  1WMW A;  5IMP A;  1V4E A;  3DYH A;  4LLS A;  5IK0 A;  5ILY A;  1VG7 A;  1YYR A;  4N9U A;  3WEI A;  4LIX A;  3SAE A;  3WCC A;  4LXW A;  3DYG A;  3OAB A;  3KRO A;  4GP1 A;  1V4H A;  5IK6 A;  1V4K A;  5IL3 A;  1WKZ A;  4LTV A;  3PYB A;  3AQC B;  1WL3 A;  4P0X A;  1ZW5 A;  1YYS A;  1YQ7 A;  4KPJ A;  4UMJ A;  3WCJ A;  3LOM A;  2VF6 A;  2ZCS A;  2AEK A;  2F8C F;  5DZ2 A;  1WL2 A;  5AEL A;  1V4J A;  5JUZ F;  3EGT A;  2PS8 A;  4RYP A;  4DEM F;  5JV0 F;  3KRA B;  3WCB A;  3ADZ A;  3OAC B;  3ACX A;  3WJN A;  2Q9Z A;  1VG2 A;  3SDR A;  1EZF A;  5DJV F;  3Q1O A;  4XQR F;  5EAS A;  5IN8 A;  3WJK A;  4GP2 A;  3KBK A;  3WCA A;  2ZCR A;  3VJD A;  4FJQ A;  4P0V A;  3TS7 A;  1YJ4 A;  2E8U A;  3EZ3 A;  3IPI A;  3OAC A;  2ZEU A;  3AQB B;  4KVI A;  3LGK A;  3N49 F;  5B0J A;  3KRC B;  5I1U A;  3ACW A;  4DXJ A;  3ICN A;  2E8X A;  1UBY A;  5ER8 A;  3VJ9 A;  2Q58 A;  3WC9 A;  3N5J F;  2E4O A;  5ILZ A;  5DJR F;  3BNX A;  3M01 A;  3PH7 A;  4PVX F;  3G4D A;  1HM4 A;  2E94 A;  3UCA A;  2ZCQ A;  2F8Z F;  3M02 A;  3ASX A;  5EAU A;  3SDT A;  4JVJ F;  3WSA A;  2PS4 A;  3MZV A;  3LK5 A;  4LLT A;  4LPH F;  4KPD A;  3M00 A;  1UBX A;  4DWB A;  4E9Z A;  4JZX A;  1RQI A;  4NKE A;  3M0G A;  5B01 A;  4HD1 A;  5JV2 F;  5ILH A;  1YYU A;  2Z78 A;  4LFG A;  2PS6 A;  3N0F A;  5CG6 A;  4DWG A;  5IKA A;  3VJC A;  3WE9 A;  3CP6 A;  2H8O A;  4F6V A;  4K10 A;  3G4F A;  4RXE A;  5B02 A;  4DZW A;  5E8L A;  5B0L A;  5IL8 A;  1KIY A;  3WEJ A;  3WSB A;  5DHI A;  5ERO A;  2Z4V A;  3KRP B;  1WL0 A;  2AZL A;  3Q2Q A;  2OPN A;  4RXA A;  2F92 F;  4FP4 A;  3P8L A;  5IK9 A;  5ILI A;  1HXC A;  4MC3 A;  4L2X F;  2ONH A;  3ZOU A;  3VJ8 A;  3PKO A;  3N3L F;  3ZMB A;  3WCD A;  4QPF A;  5DIQ F;  4LA5 A;  4KQU A;  2DH4 A;  3CC9 A;  3AQ0 A;  2EWG A;  4MC8 A;  2E95 A;  2J5C A;  4LTZ A;  2ONG A;  2F9K F;  4JXN A;  1HXG A;  3LZ9 A;  5DGS F;  3RYW A;  3WEF A;  1DI1 A;  2PS7 A;  4GAX A;  5A0J A;  1JFA A;  4OKM A;  3WCF A;  5C05 A;  3W7F A;  3N3D A;  4H5E F;  2E8W A;  2OA6 A;  3WCH A;  5DHK A;  1JFG A;  5A0K A;  3V1V A;  4JZB A;  4H5D F;  4KVY A;  2Z4Y A;  3KRA A;  1HXA A;  2Z4X A;  4LOB A;  2Z4W A;  4JXY A;  4P0W A;  5E8K A;  4N1Z F;  4DHD A;  2Z52 A;  4OMG A;  3SDV A;  3NPK A;  3QKC A;  4WK5 A;  4NFJ F;  2F7M F;  3IBA A;  3LGZ B;  4PVY F;  4KWD A;  3VJB A;  1N21 A;  2OGD A;  3RMG A;  4KQ5 A;  3KRC A;  2E90 A;  2ZY1 A;  4NG6 A;  2Q9Y A;  3ZMC A;  3CKE A;  5DGM F;  5AHU B;  2Z50 A;  3ICZ A;  5EAT A;  3KRF B;  4KK2 A;  5AYP A;  3ICM A;  5IMN A;  5B00 A;  3WCG A;  3WEG A;  1UBV A;  5ERN A;  3LEE A;  2P1C A;  4E9U A;  1HX9 A;  3SDU A;  3LLW A;  4E1E A;  2E92 A;  5HN8 A;  3S4J A;  3ZCD A;  2Z4Z A;  2I19 A;  4H5C F;  3NRI A;  1KIZ A;  2AZJ A;  3QQV A;  2AZK A;  3AE0 A;  5H9D A;  2Z7H A;  3EFQ A;  1N22 A;  4LA6 A;  3WCM A;  5IM1 A;  2Q80 A;  3Q30 A;  1VG3 A;  2OPM A;  4KVW A;  5A0I A;  3N46 F;  4LFV F;  3BNY A;  5B0K A;  1VG6 A;  2E8V A;  2F89 F;  4GA3 A;  2PS5 A;  1YYT A;  3P8R A;  4XQT F;  4RXC A;  3OAB B;  3KRP A;  3TC1 A;  1N24 A;  4EA0 A;  3PDE A;  5DJP F;  3NPR A;  5IMI A;  3WEK A;  4LZ3 A;  5HN9 A;  4LUU A;  3VJE A;  3P5R A;  4LFE A;  4NFK F;  5E8H A;  1N23 A;  2RAH A;  3RBM A; 
#chains in the Genus database with same CATH homology
 3S9V A;  1YYQ A;  3P5P A;  3APZ A;  3N5H F;  1RQJ A;  1DGP A;  1YHK A;  3WCI A;  2FTZ A;  3LMD A;  1WY0 A;  3N1W F;  5HN7 A;  4LZC A;  2ZEV A;  3P41 A;  5ILJ A;  3LSN A;  3KB9 A;  1RTR A;  4QXS F;  5AFX A;  5JA0 F;  1PS1 A;  3ZL6 A;  2FOR A;  3SDQ A;  4NKF A;  2ZCO A;  3N0G A;  3V66 A;  4LPG F;  5KSX F;  3ID0 A;  2J1P A;  3N1V F;  4XQS F;  1V4I A;  3WCL A;  1VG4 A;  3N45 F;  3DYF A;  3LG5 A;  4OKZ A;  4KFA A;  3WJO A;  1YV5 A;  3LDW A;  1WL1 A;  1N20 A;  4KKM A;  5ILK A;  1YHM A;  4MC0 A;  2E91 A;  3MAV A;  2F94 F;  3OYR A;  3Q2Z A;  4KVD A;  4Q23 A;  4ZQ8 A;  1FPS A;  1UBW A;  1HM7 A;  4NFI F;  5B0I A;  3VJA A;  4LZ0 A;  4OMH A;  3M9U A;  2QIS A;  5JV1 F;  2AET A;  4OGU A;  3LVS A;  5B03 A;  3ICK A;  4F62 A;  2E93 A;  5B0M A;  5IVG A;  3PYA A;  4RNQ A;  3N6K F;  3NF2 A;  3WEH A;  2O1O A;  1N1B A;  3ACY A;  5IKH A;  3V1X A;  5ERM A;  4EA2 A;  3KRF A;  3RYE A;  3TFP A;  2E8T A;  5ILD A;  4JYX A;  1YHL A;  4KUX A;  2J1O A;  3LJI A;  2Z7I A;  5DGN F;  3WCE A;  3TFV A;  4NUA A;  4DI5 A;  5CG5 A;  2AEL A;  4EA1 A;  5HNA A;  4F6X A;  5DW7 A;  3KRO B;  1N1Z A;  4KQS A;  3B7L A;  3TFN A;  4RXD A;  1WMW A;  5IMP A;  1V4E A;  3DYH A;  4LLS A;  5IK0 A;  5ILY A;  1VG7 A;  1YYR A;  4N9U A;  3WEI A;  4LIX A;  3SAE A;  3WCC A;  4LXW A;  3DYG A;  3OAB A;  3KRO A;  4GP1 A;  1V4H A;  5IK6 A;  1V4K A;  5IL3 A;  1WKZ A;  4LTV A;  3PYB A;  3AQC B;  1WL3 A;  4P0X A;  1ZW5 A;  1YYS A;  1YQ7 A;  4KPJ A;  4UMJ A;  3WCJ A;  3LOM A;  2VF6 A;  2ZCS A;  2AEK A;  2F8C F;  5DZ2 A;  1WL2 A;  5AEL A;  1V4J A;  5JUZ F;  3EGT A;  2PS8 A;  4RYP A;  4DEM F;  5JV0 F;  3KRA B;  3WCB A;  3ADZ A;  3OAC B;  3ACX A;  3WJN A;  2Q9Z A;  1VG2 A;  3SDR A;  1EZF A;  5DJV F;  3Q1O A;  4XQR F;  5EAS A;  5IN8 A;  3WJK A;  4GP2 A;  3KBK A;  3WCA A;  2ZCR A;  3VJD A;  4FJQ A;  4P0V A;  3TS7 A;  1YJ4 A;  2E8U A;  3EZ3 A;  3IPI A;  3OAC A;  2ZEU A;  3AQB B;  4KVI A;  3LGK A;  3N49 F;  5B0J A;  3KRC B;  5I1U A;  3ACW A;  4DXJ A;  3ICN A;  2E8X A;  1UBY A;  5ER8 A;  3VJ9 A;  2Q58 A;  3WC9 A;  3N5J F;  2E4O A;  5ILZ A;  5DJR F;  3BNX A;  3M01 A;  3PH7 A;  4PVX F;  3G4D A;  1HM4 A;  2E94 A;  3UCA A;  2ZCQ A;  2F8Z F;  3M02 A;  3ASX A;  5EAU A;  3SDT A;  4JVJ F;  3WSA A;  2PS4 A;  3MZV A;  3LK5 A;  4LLT A;  4LPH F;  4KPD A;  3M00 A;  1UBX A;  4DWB A;  4E9Z A;  4JZX A;  1RQI A;  4NKE A;  3M0G A;  5B01 A;  4HD1 A;  5JV2 F;  5ILH A;  1YYU A;  2Z78 A;  4LFG A;  2PS6 A;  3N0F A;  5CG6 A;  4DWG A;  5IKA A;  3VJC A;  3WE9 A;  3CP6 A;  2H8O A;  4F6V A;  4K10 A;  3G4F A;  4RXE A;  5B02 A;  4DZW A;  5E8L A;  5B0L A;  5IL8 A;  1KIY A;  3WEJ A;  3WSB A;  5DHI A;  5ERO A;  2Z4V A;  3KRP B;  1WL0 A;  2AZL A;  3Q2Q A;  2OPN A;  4RXA A;  2F92 F;  4FP4 A;  3P8L A;  5IK9 A;  5ILI A;  1HXC A;  4MC3 A;  4L2X F;  2ONH A;  3ZOU A;  3VJ8 A;  3PKO A;  3N3L F;  3ZMB A;  3WCD A;  4QPF A;  5DIQ F;  4LA5 A;  4KQU A;  2DH4 A;  3CC9 A;  3AQ0 A;  2EWG A;  4MC8 A;  2E95 A;  2J5C A;  4LTZ A;  2ONG A;  2F9K F;  4JXN A;  1HXG A;  3LZ9 A;  5DGS F;  3RYW A;  3WEF A;  1DI1 A;  2PS7 A;  4GAX A;  5A0J A;  1JFA A;  4OKM A;  3WCF A;  5C05 A;  3W7F A;  3N3D A;  4H5E F;  2E8W A;  2OA6 A;  3WCH A;  5DHK A;  1JFG A;  5A0K A;  3V1V A;  4JZB A;  4H5D F;  4KVY A;  2Z4Y A;  3KRA A;  1HXA A;  2Z4X A;  4LOB A;  2Z4W A;  4JXY A;  4P0W A;  5E8K A;  4N1Z F;  4DHD A;  2Z52 A;  4OMG A;  3SDV A;  3NPK A;  3QKC A;  4WK5 A;  4NFJ F;  2F7M F;  3IBA A;  3LGZ B;  4PVY F;  4KWD A;  3VJB A;  1N21 A;  2OGD A;  3RMG A;  4KQ5 A;  3KRC A;  2E90 A;  2ZY1 A;  4NG6 A;  2Q9Y A;  3ZMC A;  3CKE A;  5DGM F;  5AHU B;  2Z50 A;  3ICZ A;  5EAT A;  3KRF B;  4KK2 A;  5AYP A;  3ICM A;  5IMN A;  5B00 A;  3WCG A;  3WEG A;  1UBV A;  5ERN A;  3LEE A;  2P1C A;  4E9U A;  1HX9 A;  3SDU A;  3LLW A;  4E1E A;  2E92 A;  5HN8 A;  3S4J A;  3ZCD A;  2Z4Z A;  2I19 A;  4H5C F;  3NRI A;  1KIZ A;  2AZJ A;  3QQV A;  2AZK A;  3AE0 A;  5H9D A;  2Z7H A;  3EFQ A;  1N22 A;  4LA6 A;  3WCM A;  5IM1 A;  2Q80 A;  3Q30 A;  1VG3 A;  2OPM A;  4KVW A;  5A0I A;  3N46 F;  4LFV F;  3BNY A;  5B0K A;  1VG6 A;  2E8V A;  2F89 F;  4GA3 A;  2PS5 A;  1YYT A;  3P8R A;  4XQT F;  4RXC A;  3OAB B;  3KRP A;  3TC1 A;  1N24 A;  4EA0 A;  3PDE A;  5DJP F;  3NPR A;  5IMI A;  3WEK A;  4LZ3 A;  5HN9 A;  4LUU A;  3VJE A;  3P5R A;  4LFE A;  4NFK F;  5E8H A;  1N23 A;  2RAH A;  3RBM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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