4NUAA

The effects of lysine 200 and phenylalanine 239 farnesyl pyrophosphate synthase (fpps) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
342
structure length
338
Chain Sequence
AYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNTIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFAQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Farnesyl pyrophosphate synthase
publication title The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 141
structure length 338
sequence length 342
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2013-12-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4nuaA00
2E8TA 1KIZA 2Z4WA 5ILKA 3N46F 5DJRF 4LLTA 4MC3A 3Q30A 4JXNA 5HN8A 5ILZA 3N1WF 3PDEA 2F9KF 3IBAA 1WL0A 5A0JA 3G4FA 4N9UA 3WCEA 3VJCA 3VJEA 3ACXA 3AQ0A 3Q1OA 2ONGA 2Z4ZA 4NKEA 3WJKA 5DGNF 1V4JA 3KRAA 4E9ZA 4RYPA 2H8OA 1VG3A 3LSNA 3ZL6A 1N23A 3M01A 3QQVA 4KKMA 3ZCDA 5DHKA 4P0VA 3LOMA 5DGMF 5AHUB 5HNAA 5DJPF 3DYHA 5EROA 1WL3A 2P1CA 1UBWA 5C05A 4NFIF 1WL1A 3N0FA 3NRIA 3RYEA 1HXCA 2ZCQA 5DGSF 4JZBA 1N22A 2ONHA 1HXAA 4LZ0A 4OKZA 2I19A 2QISA 3TFNA 5DIQF 3SDQA 2PS5A 1V4KA 1YYRA 2AZJA 4NUAA 4DI5A 3N6KF 1WL2A 2F8CF 3LVSA 3WSBA 3WCAA 3S9VA 3N49F 3B7LA 5IVGA 5A0IA 2FORA 2E91A 1VG7A 4NKFA 2F89F 3NPKA 2OA6A 3WSAA 5IL3A 1KIYA 4ZQ8A 5JA0F 4KK2A 5IKHA 3WCIA 3ACYA 4QPFA 2ZCRA 1YYSA 3P5PA 4KPDA 4HD1A 3P8RA 3PYBA 3W7FA 3Q2ZA 1JFAA 3N5HF 4JYXA 1N21A 3V66A 3LZ9A 3SDUA 5B03A 3KROB 3WCHA 4E9UA 5IK9A 3WCFA 4MC8A 5B0LA 3DYFA 2Z4XA 3WEFA 5B0MA 4DZWA 5JUZF 4RXDA 4KQSA 3WC9A 4KQUA 5E8LA 3KRCA 1EZFA 2AEKA 3KRFB 5B0IA 2E94A 4RXEA 2EWGA 3LG5A 3RYWA 1HM4A 4GP2A 4LUUA 3UCAA 3LJIA 5EATA 5ERNA 4KUXA 1RTRA 3NPRA 4OMGA 3OACB 3ASXA 2ZEVA 4RXCA 4Q23A 3AQCB 1WMWA 1YHKA 4KFAA 4XQTF 5B0JA 2Q9ZA 3LDWA 4PVYF 3M0GA 3BNYA 3N5JF 3APZA 3WEJA 4LA5A 4LIXA 2J1PA 4P0XA 3WCGA 3KRPB 3WEHA 3KBKA 5DZ2A 4NG6A 2AETA 2E93A 2Z4YA 1UBXA 3P8LA 3OABB 1YQ7A 4KQ5A 2PS7A 5DHIA 2E90A 3VJ8A 2J1OA 3RMGA 3ZOUA 4KWDA 4LZCA 4LPHF 3TFPA 5AYPA 5I1UA 2Z52A 5ILDA 3EGTA 3WE9A 3ICZA 5E8KA 3G4DA 4EA1A 4JZXA 4K10A 2Z78A 3CC9A 4KVIA 1RQJA 1WY0A 4KVYA 4QXSF 3V1XA 5EAUA 3P5RA 5ILIA 5IMIA 3MZVA 4LA6A 2AELA 3S4JA 2RAHA 1YHLA 4JXYA 3RBMA 2PS8A 2Z7HA 3OABA 1VG4A 3VJBA 4LLSA 5ERMA 4RNQA 4LOBA 3TFVA 5ILJA 1UBVA 3CP6A 2E8UA 4F62A 1YYUA 3IPIA 3LMDA 3ID0A 3KB9A 1FPSA 1V4EA 3ZMCA 2OPMA 3N45F 4N1ZF 5AELA 3SDTA 3ICKA 4XQRF 4LFEA 3Q2QA 3LK5A 4EA0A 4PVXF 4E1EA 2Z7IA 5KSXF 3KRAB 5H9DA 2Z4VA 4GP1A 4FP4A 5IK0A 3LGZB 3WCJA 3WCBA 2ZY1A 4NFJF 3LGKA 3ZMBA 5CG6A 2E95A 5IL8A 4L2XF 2F94F 2ZCOA 2PS4A 5A0KA 2F7MF 3ACWA 3M02A 4DHDA 4LFVF 1YHMA 2AZLA 3KROA 3M9UA 4NFKF 3WJNA 5EASA 1ZW5A 4XQSF 2O1OA 4LTVA 1JFGA 5E8HA 2Z50A 1V4IA 4DEMF 2F92F 5B00A 4KVWA 3WCCA 5ILHA 1DGPA 1HXGA 4LZ3A 2VF6A 2Q58A 1N24A 1RQIA 3M00A 1VG6A 5IK6A 3KRFA 3SAEA 2Q80A 1YYTA 2F8ZF 2AZKA 3QKCA 3PYAA 1YV5A 4UMJA 2OGDA 3OYRA 3SDRA 4EA2A 4DXJA 4F6VA 4OGUA 1N1BA 1VG2A 1HM7A 2PS6A 4JVJF 4OMHA 4P0WA 5HN7A 3TS7A 5CG5A 3OACA 2DH4A 3P41A 2J5CA 2OPNA 3WCLA 5DW7A 3AQBB 1PS1A 3WCDA 3ICMA 2ZCSA 2ZEUA 5HN9A 3WEKA 5JV0F 3ICNA 3CKEA 4KPJA 3NF2A 4H5EF 3N3LF 4OKMA 3VJ9A 3KRPA 5B0KA 5ER8A 5IMNA 1N20A 1UBYA 2E92A 5IMPA 4F6XA 3PH7A 3WCMA 1YYQA 3VJDA 4H5DF 5B02A 5JV1F 3PKOA 5IKAA 3KRCB 4KVDA 3V1VA 5ILYA 3LLWA 3SDVA 2Q9YA 4FJQA 4GAXA 3BNXA 3N3DA 3WEIA 3DYGA 5JV2F 4LTZA 4LFGA 1N1ZA 4DWBA 1DI1A 3N1VF 1HX9A 3TC1A 4LPGF 4H5CF 3LEEA 5DJVF 5IN8A 3AE0A 4WK5A 4MC0A 2E8VA 4LXWA 5B01A 3N0GA 3WEGA 2E8XA 2E8WA 5AFXA 3EFQA 3WJOA 1V4HA 3MAVA 4GA3A 2FTZA 5IM1A 3VJAA 4DWGA 2E4OA 3ADZA 3EZ3A 1YJ4A 1WKZA 4RXAA
chains in the Genus database with same CATH superfamily
2E8TA 1KIZA 2Z4WA 5ILKA 3N46F 5DJRF 4LLTA 4MC3A 3Q30A 4JXNA 5HN8A 5ILZA 3N1WF 3PDEA 2F9KF 3IBAA 1WL0A 5A0JA 3G4FA 4N9UA 3WCEA 3VJCA 3VJEA 3ACXA 3AQ0A 3Q1OA 2ONGA 2Z4ZA 4NKEA 3WJKA 5DGNF 1V4JA 3KRAA 4E9ZA 4RYPA 2H8OA 1VG3A 3LSNA 3ZL6A 1N23A 3M01A 3QQVA 4KKMA 3ZCDA 5DHKA 4P0VA 3LOMA 5DGMF 5AHUB 5HNAA 5DJPF 3DYHA 5EROA 1WL3A 2P1CA 1UBWA 5C05A 4NFIF 1WL1A 3N0FA 3NRIA 3RYEA 1HXCA 2ZCQA 5DGSF 4JZBA 1N22A 2ONHA 1HXAA 4LZ0A 4OKZA 2I19A 2QISA 3TFNA 5DIQF 3SDQA 2PS5A 1V4KA 1YYRA 2AZJA 4NUAA 4DI5A 3N6KF 1WL2A 2F8CF 3LVSA 3WSBA 3WCAA 3S9VA 3N49F 3B7LA 5IVGA 5A0IA 2FORA 2E91A 1VG7A 4NKFA 2F89F 3NPKA 2OA6A 3WSAA 5IL3A 1KIYA 4ZQ8A 5JA0F 4KK2A 5IKHA 3WCIA 3ACYA 4QPFA 2ZCRA 1YYSA 3P5PA 4KPDA 4HD1A 3P8RA 3PYBA 3W7FA 3Q2ZA 1JFAA 3N5HF 4JYXA 1N21A 3V66A 3LZ9A 3SDUA 5B03A 3KROB 3WCHA 4E9UA 5IK9A 3WCFA 4MC8A 5B0LA 3DYFA 2Z4XA 3WEFA 5B0MA 4DZWA 5JUZF 4RXDA 4KQSA 3WC9A 4KQUA 5E8LA 3KRCA 1EZFA 2AEKA 3KRFB 5B0IA 2E94A 4RXEA 2EWGA 3LG5A 3RYWA 1HM4A 4GP2A 4LUUA 3UCAA 3LJIA 5EATA 5ERNA 4KUXA 1RTRA 3NPRA 4OMGA 3OACB 3ASXA 2ZEVA 4RXCA 4Q23A 3AQCB 1WMWA 1YHKA 4KFAA 4XQTF 5B0JA 2Q9ZA 3LDWA 4PVYF 3M0GA 3BNYA 3N5JF 3APZA 3WEJA 4LA5A 4LIXA 2J1PA 4P0XA 3WCGA 3KRPB 3WEHA 3KBKA 5DZ2A 4NG6A 2AETA 2E93A 2Z4YA 1UBXA 3P8LA 3OABB 1YQ7A 4KQ5A 2PS7A 5DHIA 2E90A 3VJ8A 2J1OA 3RMGA 3ZOUA 4KWDA 4LZCA 4LPHF 3TFPA 5AYPA 5I1UA 2Z52A 5ILDA 3EGTA 3WE9A 3ICZA 5E8KA 3G4DA 4EA1A 4JZXA 4K10A 2Z78A 3CC9A 4KVIA 1RQJA 1WY0A 4KVYA 4QXSF 3V1XA 5EAUA 3P5RA 5ILIA 5IMIA 3MZVA 4LA6A 2AELA 3S4JA 2RAHA 1YHLA 4JXYA 3RBMA 2PS8A 2Z7HA 3OABA 1VG4A 3VJBA 4LLSA 5ERMA 4RNQA 4LOBA 3TFVA 5ILJA 1UBVA 3CP6A 2E8UA 4F62A 1YYUA 3IPIA 3LMDA 3ID0A 3KB9A 1FPSA 1V4EA 3ZMCA 2OPMA 3N45F 4N1ZF 5AELA 3SDTA 3ICKA 4XQRF 4LFEA 3Q2QA 3LK5A 4EA0A 4PVXF 4E1EA 2Z7IA 5KSXF 3KRAB 5H9DA 2Z4VA 4GP1A 4FP4A 5IK0A 3LGZB 3WCJA 3WCBA 2ZY1A 4NFJF 3LGKA 3ZMBA 5CG6A 2E95A 5IL8A 4L2XF 2F94F 2ZCOA 2PS4A 5A0KA 2F7MF 3ACWA 3M02A 4DHDA 4LFVF 1YHMA 2AZLA 3KROA 3M9UA 4NFKF 3WJNA 5EASA 1ZW5A 4XQSF 2O1OA 4LTVA 1JFGA 5E8HA 2Z50A 1V4IA 4DEMF 2F92F 5B00A 4KVWA 3WCCA 5ILHA 1DGPA 1HXGA 4LZ3A 2VF6A 2Q58A 1N24A 1RQIA 3M00A 1VG6A 5IK6A 3KRFA 3SAEA 2Q80A 1YYTA 2F8ZF 2AZKA 3QKCA 3PYAA 1YV5A 4UMJA 2OGDA 3OYRA 3SDRA 4EA2A 4DXJA 4F6VA 4OGUA 1N1BA 1VG2A 1HM7A 2PS6A 4JVJF 4OMHA 4P0WA 5HN7A 3TS7A 5CG5A 3OACA 2DH4A 3P41A 2J5CA 2OPNA 3WCLA 5DW7A 3AQBB 1PS1A 3WCDA 3ICMA 2ZCSA 2ZEUA 5HN9A 3WEKA 5JV0F 3ICNA 3CKEA 4KPJA 3NF2A 4H5EF 3N3LF 4OKMA 3VJ9A 3KRPA 5B0KA 5ER8A 5IMNA 1N20A 1UBYA 2E92A 5IMPA 4F6XA 3PH7A 3WCMA 1YYQA 3VJDA 4H5DF 5B02A 5JV1F 3PKOA 5IKAA 3KRCB 4KVDA 3V1VA 5ILYA 3LLWA 3SDVA 2Q9YA 4FJQA 4GAXA 3BNXA 3N3DA 3WEIA 3DYGA 5JV2F 4LTZA 4LFGA 1N1ZA 4DWBA 1DI1A 3N1VF 1HX9A 3TC1A 4LPGF 4H5CF 3LEEA 5DJVF 5IN8A 3AE0A 4WK5A 4MC0A 2E8VA 4LXWA 5B01A 3N0GA 3WEGA 2E8XA 2E8WA 5AFXA 3EFQA 3WJOA 1V4HA 3MAVA 4GA3A 2FTZA 5IM1A 3VJAA 4DWGA 2E4OA 3ADZA 3EZ3A 1YJ4A 1WKZA 4RXAA
chains in the Genus database with same CATH topology
2E8TA 1KIZA 2Z4WA 5ILKA 3N46F 5DJRF 4LLTA 4MC3A 3Q30A 4JXNA 5HN8A 5ILZA 3N1WF 3PDEA 2F9KF 3IBAA 1WL0A 5A0JA 3G4FA 4N9UA 3WCEA 3VJCA 3VJEA 3ACXA 3AQ0A 3Q1OA 2ONGA 2Z4ZA 4NKEA 3WJKA 5DGNF 1V4JA 3KRAA 4E9ZA 4RYPA 2H8OA 1VG3A 3LSNA 3ZL6A 1N23A 3M01A 3QQVA 4KKMA 3ZCDA 5DHKA 4P0VA 3LOMA 5DGMF 5AHUB 5HNAA 5DJPF 3DYHA 5EROA 1WL3A 2P1CA 1UBWA 5C05A 4NFIF 1WL1A 3N0FA 3NRIA 3RYEA 1HXCA 2ZCQA 5DGSF 4JZBA 1N22A 2ONHA 1HXAA 4LZ0A 4OKZA 2I19A 2QISA 3TFNA 5DIQF 3SDQA 2PS5A 1V4KA 1YYRA 2AZJA 4NUAA 4DI5A 3N6KF 1WL2A 2F8CF 3LVSA 3WSBA 3WCAA 3S9VA 3N49F 3B7LA 5IVGA 5A0IA 2FORA 2E91A 1VG7A 4NKFA 2F89F 3NPKA 2OA6A 3WSAA 5IL3A 1KIYA 4ZQ8A 5JA0F 4KK2A 5IKHA 3WCIA 3ACYA 4QPFA 2ZCRA 1YYSA 3P5PA 4KPDA 4HD1A 3P8RA 3PYBA 3W7FA 3Q2ZA 1JFAA 3N5HF 4JYXA 1N21A 3V66A 3LZ9A 3SDUA 5B03A 3KROB 3WCHA 4E9UA 5IK9A 3WCFA 4MC8A 5B0LA 3DYFA 2Z4XA 3WEFA 5B0MA 4DZWA 5JUZF 4RXDA 4KQSA 3WC9A 4KQUA 5E8LA 3KRCA 1EZFA 2AEKA 3KRFB 5B0IA 2E94A 4RXEA 2EWGA 3LG5A 3RYWA 1HM4A 4GP2A 4LUUA 3UCAA 3LJIA 5EATA 5ERNA 4KUXA 1RTRA 3NPRA 4OMGA 3OACB 3ASXA 2ZEVA 4RXCA 4Q23A 3AQCB 1WMWA 1YHKA 4KFAA 4XQTF 5B0JA 2Q9ZA 3LDWA 4PVYF 3M0GA 3BNYA 3N5JF 3APZA 3WEJA 4LA5A 4LIXA 2J1PA 4P0XA 3WCGA 3KRPB 3WEHA 3KBKA 5DZ2A 4NG6A 2AETA 2E93A 2Z4YA 1UBXA 3P8LA 3OABB 1YQ7A 4KQ5A 2PS7A 5DHIA 2E90A 3VJ8A 2J1OA 3RMGA 3ZOUA 4KWDA 4LZCA 4LPHF 3TFPA 5AYPA 5I1UA 2Z52A 5ILDA 3EGTA 3WE9A 3ICZA 5E8KA 3G4DA 4EA1A 4JZXA 4K10A 2Z78A 3CC9A 4KVIA 1RQJA 1WY0A 4KVYA 4QXSF 3V1XA 5EAUA 3P5RA 5ILIA 5IMIA 3MZVA 4LA6A 2AELA 3S4JA 2RAHA 1YHLA 4JXYA 3RBMA 2PS8A 2Z7HA 3OABA 1VG4A 3VJBA 4LLSA 5ERMA 4RNQA 4LOBA 3TFVA 5ILJA 1UBVA 3CP6A 2E8UA 4F62A 1YYUA 3IPIA 3LMDA 3ID0A 3KB9A 1FPSA 1V4EA 3ZMCA 2OPMA 3N45F 4N1ZF 5AELA 3SDTA 3ICKA 4XQRF 4LFEA 3Q2QA 3LK5A 4EA0A 4PVXF 4E1EA 2Z7IA 5KSXF 3KRAB 5H9DA 2Z4VA 4GP1A 4FP4A 5IK0A 3LGZB 3WCJA 3WCBA 2ZY1A 4NFJF 3LGKA 3ZMBA 5CG6A 2E95A 5IL8A 4L2XF 2F94F 2ZCOA 2PS4A 5A0KA 2F7MF 3ACWA 3M02A 4DHDA 4LFVF 1YHMA 2AZLA 3KROA 3M9UA 4NFKF 3WJNA 5EASA 1ZW5A 4XQSF 2O1OA 4LTVA 1JFGA 5E8HA 2Z50A 1V4IA 4DEMF 2F92F 5B00A 4KVWA 3WCCA 5ILHA 1DGPA 1HXGA 4LZ3A 2VF6A 2Q58A 1N24A 1RQIA 3M00A 1VG6A 5IK6A 3KRFA 3SAEA 2Q80A 1YYTA 2F8ZF 2AZKA 3QKCA 3PYAA 1YV5A 4UMJA 2OGDA 3OYRA 3SDRA 4EA2A 4DXJA 4F6VA 4OGUA 1N1BA 1VG2A 1HM7A 2PS6A 4JVJF 4OMHA 4P0WA 5HN7A 3TS7A 5CG5A 3OACA 2DH4A 3P41A 2J5CA 2OPNA 3WCLA 5DW7A 3AQBB 1PS1A 3WCDA 3ICMA 2ZCSA 2ZEUA 5HN9A 3WEKA 5JV0F 3ICNA 3CKEA 4KPJA 3NF2A 4H5EF 3N3LF 4OKMA 3VJ9A 3KRPA 5B0KA 5ER8A 5IMNA 1N20A 1UBYA 2E92A 5IMPA 4F6XA 3PH7A 3WCMA 1YYQA 3VJDA 4H5DF 5B02A 5JV1F 3PKOA 5IKAA 3KRCB 4KVDA 3V1VA 5ILYA 3LLWA 3SDVA 2Q9YA 4FJQA 4GAXA 3BNXA 3N3DA 3WEIA 3DYGA 5JV2F 4LTZA 4LFGA 1N1ZA 4DWBA 1DI1A 3N1VF 1HX9A 3TC1A 4LPGF 4H5CF 3LEEA 5DJVF 5IN8A 3AE0A 4WK5A 4MC0A 2E8VA 4LXWA 5B01A 3N0GA 3WEGA 2E8XA 2E8WA 5AFXA 3EFQA 3WJOA 1V4HA 3MAVA 4GA3A 2FTZA 5IM1A 3VJAA 4DWGA 2E4OA 3ADZA 3EZ3A 1YJ4A 1WKZA 4RXAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2E8T A;  1KIZ A;  2Z4W A;  5ILK A;  3N46 F;  5DJR F;  4LLT A;  4MC3 A;  3Q30 A;  4JXN A;  5HN8 A;  5ILZ A;  3N1W F;  3PDE A;  2F9K F;  3IBA A;  1WL0 A;  5A0J A;  3G4F A;  4N9U A;  3WCE A;  3VJC A;  3VJE A;  3ACX A;  3AQ0 A;  3Q1O A;  2ONG A;  2Z4Z A;  4NKE A;  3WJK A;  5DGN F;  1V4J A;  3KRA A;  4E9Z A;  4RYP A;  2H8O A;  1VG3 A;  3LSN A;  3ZL6 A;  1N23 A;  3M01 A;  3QQV A;  4KKM A;  3ZCD A;  5DHK A;  4P0V A;  3LOM A;  5DGM F;  5AHU B;  5HNA A;  5DJP F;  3DYH A;  5ERO A;  1WL3 A;  2P1C A;  1UBW A;  5C05 A;  4NFI F;  1WL1 A;  3N0F A;  3NRI A;  3RYE A;  1HXC A;  2ZCQ A;  5DGS F;  4JZB A;  1N22 A;  2ONH A;  1HXA A;  4LZ0 A;  4OKZ A;  2I19 A;  2QIS A;  3TFN A;  5DIQ F;  3SDQ A;  2PS5 A;  1V4K A;  1YYR A;  2AZJ A;  4NUA A;  4DI5 A;  3N6K F;  1WL2 A;  2F8C F;  3LVS A;  3WSB A;  3WCA A;  3S9V A;  3N49 F;  3B7L A;  5IVG A;  5A0I A;  2FOR A;  2E91 A;  1VG7 A;  4NKF A;  2F89 F;  3NPK A;  2OA6 A;  3WSA A;  5IL3 A;  1KIY A;  4ZQ8 A;  5JA0 F;  4KK2 A;  5IKH A;  3WCI A;  3ACY A;  4QPF A;  2ZCR A;  1YYS A;  3P5P A;  4KPD A;  4HD1 A;  3P8R A;  3PYB A;  3W7F A;  3Q2Z A;  1JFA A;  3N5H F;  4JYX A;  1N21 A;  3V66 A;  3LZ9 A;  3SDU A;  5B03 A;  3KRO B;  3WCH A;  4E9U A;  5IK9 A;  3WCF A;  4MC8 A;  5B0L A;  3DYF A;  2Z4X A;  3WEF A;  5B0M A;  4DZW A;  5JUZ F;  4RXD A;  4KQS A;  3WC9 A;  4KQU A;  5E8L A;  3KRC A;  1EZF A;  2AEK A;  3KRF B;  5B0I A;  2E94 A;  4RXE A;  2EWG A;  3LG5 A;  3RYW A;  1HM4 A;  4GP2 A;  4LUU A;  3UCA A;  3LJI A;  5EAT A;  5ERN A;  4KUX A;  1RTR A;  3NPR A;  4OMG A;  3OAC B;  3ASX A;  2ZEV A;  4RXC A;  4Q23 A;  3AQC B;  1WMW A;  1YHK A;  4KFA A;  4XQT F;  5B0J A;  2Q9Z A;  3LDW A;  4PVY F;  3M0G A;  3BNY A;  3N5J F;  3APZ A;  3WEJ A;  4LA5 A;  4LIX A;  2J1P A;  4P0X A;  3WCG A;  3KRP B;  3WEH A;  3KBK A;  5DZ2 A;  4NG6 A;  2AET A;  2E93 A;  2Z4Y A;  1UBX A;  3P8L A;  3OAB B;  1YQ7 A;  4KQ5 A;  2PS7 A;  5DHI A;  2E90 A;  3VJ8 A;  2J1O A;  3RMG A;  3ZOU A;  4KWD A;  4LZC A;  4LPH F;  3TFP A;  5AYP A;  5I1U A;  2Z52 A;  5ILD A;  3EGT A;  3WE9 A;  3ICZ A;  5E8K A;  3G4D A;  4EA1 A;  4JZX A;  4K10 A;  2Z78 A;  3CC9 A;  4KVI A;  1RQJ A;  1WY0 A;  4KVY A;  4QXS F;  3V1X A;  5EAU A;  3P5R A;  5ILI A;  5IMI A;  3MZV A;  4LA6 A;  2AEL A;  3S4J A;  2RAH A;  1YHL A;  4JXY A;  3RBM A;  2PS8 A;  2Z7H A;  3OAB A;  1VG4 A;  3VJB A;  4LLS A;  5ERM A;  4RNQ A;  4LOB A;  3TFV A;  5ILJ A;  1UBV A;  3CP6 A;  2E8U A;  4F62 A;  1YYU A;  3IPI A;  3LMD A;  3ID0 A;  3KB9 A;  1FPS A;  1V4E A;  3ZMC A;  2OPM A;  3N45 F;  4N1Z F;  5AEL A;  3SDT A;  3ICK A;  4XQR F;  4LFE A;  3Q2Q A;  3LK5 A;  4EA0 A;  4PVX F;  4E1E A;  2Z7I A;  5KSX F;  3KRA B;  5H9D A;  2Z4V A;  4GP1 A;  4FP4 A;  5IK0 A;  3LGZ B;  3WCJ A;  3WCB A;  2ZY1 A;  4NFJ F;  3LGK A;  3ZMB A;  5CG6 A;  2E95 A;  5IL8 A;  4L2X F;  2F94 F;  2ZCO A;  2PS4 A;  5A0K A;  2F7M F;  3ACW A;  3M02 A;  4DHD A;  4LFV F;  1YHM A;  2AZL A;  3KRO A;  3M9U A;  4NFK F;  3WJN A;  5EAS A;  1ZW5 A;  4XQS F;  2O1O A;  4LTV A;  1JFG A;  5E8H A;  2Z50 A;  1V4I A;  4DEM F;  2F92 F;  5B00 A;  4KVW A;  3WCC A;  5ILH A;  1DGP A;  1HXG A;  4LZ3 A;  2VF6 A;  2Q58 A;  1N24 A;  1RQI A;  3M00 A;  1VG6 A;  5IK6 A;  3KRF A;  3SAE A;  2Q80 A;  1YYT A;  2F8Z F;  2AZK A;  3QKC A;  3PYA A;  1YV5 A;  4UMJ A;  2OGD A;  3OYR A;  3SDR A;  4EA2 A;  4DXJ A;  4F6V A;  4OGU A;  1N1B A;  1VG2 A;  1HM7 A;  2PS6 A;  4JVJ F;  4OMH A;  4P0W A;  5HN7 A;  3TS7 A;  5CG5 A;  3OAC A;  2DH4 A;  3P41 A;  2J5C A;  2OPN A;  3WCL A;  5DW7 A;  3AQB B;  1PS1 A;  3WCD A;  3ICM A;  2ZCS A;  2ZEU A;  5HN9 A;  3WEK A;  5JV0 F;  3ICN A;  3CKE A;  4KPJ A;  3NF2 A;  4H5E F;  3N3L F;  4OKM A;  3VJ9 A;  3KRP A;  5B0K A;  5ER8 A;  5IMN A;  1N20 A;  1UBY A;  2E92 A;  5IMP A;  4F6X A;  3PH7 A;  3WCM A;  1YYQ A;  3VJD A;  4H5D F;  5B02 A;  5JV1 F;  3PKO A;  5IKA A;  3KRC B;  4KVD A;  3V1V A;  5ILY A;  3LLW A;  3SDV A;  2Q9Y A;  4FJQ A;  4GAX A;  3BNX A;  3N3D A;  3WEI A;  3DYG A;  5JV2 F;  4LTZ A;  4LFG A;  1N1Z A;  4DWB A;  1DI1 A;  3N1V F;  1HX9 A;  3TC1 A;  4LPG F;  4H5C F;  3LEE A;  5DJV F;  5IN8 A;  3AE0 A;  4WK5 A;  4MC0 A;  2E8V A;  4LXW A;  5B01 A;  3N0G A;  3WEG A;  2E8X A;  2E8W A;  5AFX A;  3EFQ A;  3WJO A;  1V4H A;  3MAV A;  4GA3 A;  2FTZ A;  5IM1 A;  3VJA A;  4DWG A;  2E4O A;  3ADZ A;  3EZ3 A;  1YJ4 A;  1WKZ A;  4RXA A; 
#chains in the Genus database with same CATH topology
 2E8T A;  1KIZ A;  2Z4W A;  5ILK A;  3N46 F;  5DJR F;  4LLT A;  4MC3 A;  3Q30 A;  4JXN A;  5HN8 A;  5ILZ A;  3N1W F;  3PDE A;  2F9K F;  3IBA A;  1WL0 A;  5A0J A;  3G4F A;  4N9U A;  3WCE A;  3VJC A;  3VJE A;  3ACX A;  3AQ0 A;  3Q1O A;  2ONG A;  2Z4Z A;  4NKE A;  3WJK A;  5DGN F;  1V4J A;  3KRA A;  4E9Z A;  4RYP A;  2H8O A;  1VG3 A;  3LSN A;  3ZL6 A;  1N23 A;  3M01 A;  3QQV A;  4KKM A;  3ZCD A;  5DHK A;  4P0V A;  3LOM A;  5DGM F;  5AHU B;  5HNA A;  5DJP F;  3DYH A;  5ERO A;  1WL3 A;  2P1C A;  1UBW A;  5C05 A;  4NFI F;  1WL1 A;  3N0F A;  3NRI A;  3RYE A;  1HXC A;  2ZCQ A;  5DGS F;  4JZB A;  1N22 A;  2ONH A;  1HXA A;  4LZ0 A;  4OKZ A;  2I19 A;  2QIS A;  3TFN A;  5DIQ F;  3SDQ A;  2PS5 A;  1V4K A;  1YYR A;  2AZJ A;  4NUA A;  4DI5 A;  3N6K F;  1WL2 A;  2F8C F;  3LVS A;  3WSB A;  3WCA A;  3S9V A;  3N49 F;  3B7L A;  5IVG A;  5A0I A;  2FOR A;  2E91 A;  1VG7 A;  4NKF A;  2F89 F;  3NPK A;  2OA6 A;  3WSA A;  5IL3 A;  1KIY A;  4ZQ8 A;  5JA0 F;  4KK2 A;  5IKH A;  3WCI A;  3ACY A;  4QPF A;  2ZCR A;  1YYS A;  3P5P A;  4KPD A;  4HD1 A;  3P8R A;  3PYB A;  3W7F A;  3Q2Z A;  1JFA A;  3N5H F;  4JYX A;  1N21 A;  3V66 A;  3LZ9 A;  3SDU A;  5B03 A;  3KRO B;  3WCH A;  4E9U A;  5IK9 A;  3WCF A;  4MC8 A;  5B0L A;  3DYF A;  2Z4X A;  3WEF A;  5B0M A;  4DZW A;  5JUZ F;  4RXD A;  4KQS A;  3WC9 A;  4KQU A;  5E8L A;  3KRC A;  1EZF A;  2AEK A;  3KRF B;  5B0I A;  2E94 A;  4RXE A;  2EWG A;  3LG5 A;  3RYW A;  1HM4 A;  4GP2 A;  4LUU A;  3UCA A;  3LJI A;  5EAT A;  5ERN A;  4KUX A;  1RTR A;  3NPR A;  4OMG A;  3OAC B;  3ASX A;  2ZEV A;  4RXC A;  4Q23 A;  3AQC B;  1WMW A;  1YHK A;  4KFA A;  4XQT F;  5B0J A;  2Q9Z A;  3LDW A;  4PVY F;  3M0G A;  3BNY A;  3N5J F;  3APZ A;  3WEJ A;  4LA5 A;  4LIX A;  2J1P A;  4P0X A;  3WCG A;  3KRP B;  3WEH A;  3KBK A;  5DZ2 A;  4NG6 A;  2AET A;  2E93 A;  2Z4Y A;  1UBX A;  3P8L A;  3OAB B;  1YQ7 A;  4KQ5 A;  2PS7 A;  5DHI A;  2E90 A;  3VJ8 A;  2J1O A;  3RMG A;  3ZOU A;  4KWD A;  4LZC A;  4LPH F;  3TFP A;  5AYP A;  5I1U A;  2Z52 A;  5ILD A;  3EGT A;  3WE9 A;  3ICZ A;  5E8K A;  3G4D A;  4EA1 A;  4JZX A;  4K10 A;  2Z78 A;  3CC9 A;  4KVI A;  1RQJ A;  1WY0 A;  4KVY A;  4QXS F;  3V1X A;  5EAU A;  3P5R A;  5ILI A;  5IMI A;  3MZV A;  4LA6 A;  2AEL A;  3S4J A;  2RAH A;  1YHL A;  4JXY A;  3RBM A;  2PS8 A;  2Z7H A;  3OAB A;  1VG4 A;  3VJB A;  4LLS A;  5ERM A;  4RNQ A;  4LOB A;  3TFV A;  5ILJ A;  1UBV A;  3CP6 A;  2E8U A;  4F62 A;  1YYU A;  3IPI A;  3LMD A;  3ID0 A;  3KB9 A;  1FPS A;  1V4E A;  3ZMC A;  2OPM A;  3N45 F;  4N1Z F;  5AEL A;  3SDT A;  3ICK A;  4XQR F;  4LFE A;  3Q2Q A;  3LK5 A;  4EA0 A;  4PVX F;  4E1E A;  2Z7I A;  5KSX F;  3KRA B;  5H9D A;  2Z4V A;  4GP1 A;  4FP4 A;  5IK0 A;  3LGZ B;  3WCJ A;  3WCB A;  2ZY1 A;  4NFJ F;  3LGK A;  3ZMB A;  5CG6 A;  2E95 A;  5IL8 A;  4L2X F;  2F94 F;  2ZCO A;  2PS4 A;  5A0K A;  2F7M F;  3ACW A;  3M02 A;  4DHD A;  4LFV F;  1YHM A;  2AZL A;  3KRO A;  3M9U A;  4NFK F;  3WJN A;  5EAS A;  1ZW5 A;  4XQS F;  2O1O A;  4LTV A;  1JFG A;  5E8H A;  2Z50 A;  1V4I A;  4DEM F;  2F92 F;  5B00 A;  4KVW A;  3WCC A;  5ILH A;  1DGP A;  1HXG A;  4LZ3 A;  2VF6 A;  2Q58 A;  1N24 A;  1RQI A;  3M00 A;  1VG6 A;  5IK6 A;  3KRF A;  3SAE A;  2Q80 A;  1YYT A;  2F8Z F;  2AZK A;  3QKC A;  3PYA A;  1YV5 A;  4UMJ A;  2OGD A;  3OYR A;  3SDR A;  4EA2 A;  4DXJ A;  4F6V A;  4OGU A;  1N1B A;  1VG2 A;  1HM7 A;  2PS6 A;  4JVJ F;  4OMH A;  4P0W A;  5HN7 A;  3TS7 A;  5CG5 A;  3OAC A;  2DH4 A;  3P41 A;  2J5C A;  2OPN A;  3WCL A;  5DW7 A;  3AQB B;  1PS1 A;  3WCD A;  3ICM A;  2ZCS A;  2ZEU A;  5HN9 A;  3WEK A;  5JV0 F;  3ICN A;  3CKE A;  4KPJ A;  3NF2 A;  4H5E F;  3N3L F;  4OKM A;  3VJ9 A;  3KRP A;  5B0K A;  5ER8 A;  5IMN A;  1N20 A;  1UBY A;  2E92 A;  5IMP A;  4F6X A;  3PH7 A;  3WCM A;  1YYQ A;  3VJD A;  4H5D F;  5B02 A;  5JV1 F;  3PKO A;  5IKA A;  3KRC B;  4KVD A;  3V1V A;  5ILY A;  3LLW A;  3SDV A;  2Q9Y A;  4FJQ A;  4GAX A;  3BNX A;  3N3D A;  3WEI A;  3DYG A;  5JV2 F;  4LTZ A;  4LFG A;  1N1Z A;  4DWB A;  1DI1 A;  3N1V F;  1HX9 A;  3TC1 A;  4LPG F;  4H5C F;  3LEE A;  5DJV F;  5IN8 A;  3AE0 A;  4WK5 A;  4MC0 A;  2E8V A;  4LXW A;  5B01 A;  3N0G A;  3WEG A;  2E8X A;  2E8W A;  5AFX A;  3EFQ A;  3WJO A;  1V4H A;  3MAV A;  4GA3 A;  2FTZ A;  5IM1 A;  3VJA A;  4DWG A;  2E4O A;  3ADZ A;  3EZ3 A;  1YJ4 A;  1WKZ A;  4RXA A; 
#chains in the Genus database with same CATH homology
 2E8T A;  1KIZ A;  2Z4W A;  5ILK A;  3N46 F;  5DJR F;  4LLT A;  4MC3 A;  3Q30 A;  4JXN A;  5HN8 A;  5ILZ A;  3N1W F;  3PDE A;  2F9K F;  3IBA A;  1WL0 A;  5A0J A;  3G4F A;  4N9U A;  3WCE A;  3VJC A;  3VJE A;  3ACX A;  3AQ0 A;  3Q1O A;  2ONG A;  2Z4Z A;  4NKE A;  3WJK A;  5DGN F;  1V4J A;  3KRA A;  4E9Z A;  4RYP A;  2H8O A;  1VG3 A;  3LSN A;  3ZL6 A;  1N23 A;  3M01 A;  3QQV A;  4KKM A;  3ZCD A;  5DHK A;  4P0V A;  3LOM A;  5DGM F;  5AHU B;  5HNA A;  5DJP F;  3DYH A;  5ERO A;  1WL3 A;  2P1C A;  1UBW A;  5C05 A;  4NFI F;  1WL1 A;  3N0F A;  3NRI A;  3RYE A;  1HXC A;  2ZCQ A;  5DGS F;  4JZB A;  1N22 A;  2ONH A;  1HXA A;  4LZ0 A;  4OKZ A;  2I19 A;  2QIS A;  3TFN A;  5DIQ F;  3SDQ A;  2PS5 A;  1V4K A;  1YYR A;  2AZJ A;  4NUA A;  4DI5 A;  3N6K F;  1WL2 A;  2F8C F;  3LVS A;  3WSB A;  3WCA A;  3S9V A;  3N49 F;  3B7L A;  5IVG A;  5A0I A;  2FOR A;  2E91 A;  1VG7 A;  4NKF A;  2F89 F;  3NPK A;  2OA6 A;  3WSA A;  5IL3 A;  1KIY A;  4ZQ8 A;  5JA0 F;  4KK2 A;  5IKH A;  3WCI A;  3ACY A;  4QPF A;  2ZCR A;  1YYS A;  3P5P A;  4KPD A;  4HD1 A;  3P8R A;  3PYB A;  3W7F A;  3Q2Z A;  1JFA A;  3N5H F;  4JYX A;  1N21 A;  3V66 A;  3LZ9 A;  3SDU A;  5B03 A;  3KRO B;  3WCH A;  4E9U A;  5IK9 A;  3WCF A;  4MC8 A;  5B0L A;  3DYF A;  2Z4X A;  3WEF A;  5B0M A;  4DZW A;  5JUZ F;  4RXD A;  4KQS A;  3WC9 A;  4KQU A;  5E8L A;  3KRC A;  1EZF A;  2AEK A;  3KRF B;  5B0I A;  2E94 A;  4RXE A;  2EWG A;  3LG5 A;  3RYW A;  1HM4 A;  4GP2 A;  4LUU A;  3UCA A;  3LJI A;  5EAT A;  5ERN A;  4KUX A;  1RTR A;  3NPR A;  4OMG A;  3OAC B;  3ASX A;  2ZEV A;  4RXC A;  4Q23 A;  3AQC B;  1WMW A;  1YHK A;  4KFA A;  4XQT F;  5B0J A;  2Q9Z A;  3LDW A;  4PVY F;  3M0G A;  3BNY A;  3N5J F;  3APZ A;  3WEJ A;  4LA5 A;  4LIX A;  2J1P A;  4P0X A;  3WCG A;  3KRP B;  3WEH A;  3KBK A;  5DZ2 A;  4NG6 A;  2AET A;  2E93 A;  2Z4Y A;  1UBX A;  3P8L A;  3OAB B;  1YQ7 A;  4KQ5 A;  2PS7 A;  5DHI A;  2E90 A;  3VJ8 A;  2J1O A;  3RMG A;  3ZOU A;  4KWD A;  4LZC A;  4LPH F;  3TFP A;  5AYP A;  5I1U A;  2Z52 A;  5ILD A;  3EGT A;  3WE9 A;  3ICZ A;  5E8K A;  3G4D A;  4EA1 A;  4JZX A;  4K10 A;  2Z78 A;  3CC9 A;  4KVI A;  1RQJ A;  1WY0 A;  4KVY A;  4QXS F;  3V1X A;  5EAU A;  3P5R A;  5ILI A;  5IMI A;  3MZV A;  4LA6 A;  2AEL A;  3S4J A;  2RAH A;  1YHL A;  4JXY A;  3RBM A;  2PS8 A;  2Z7H A;  3OAB A;  1VG4 A;  3VJB A;  4LLS A;  5ERM A;  4RNQ A;  4LOB A;  3TFV A;  5ILJ A;  1UBV A;  3CP6 A;  2E8U A;  4F62 A;  1YYU A;  3IPI A;  3LMD A;  3ID0 A;  3KB9 A;  1FPS A;  1V4E A;  3ZMC A;  2OPM A;  3N45 F;  4N1Z F;  5AEL A;  3SDT A;  3ICK A;  4XQR F;  4LFE A;  3Q2Q A;  3LK5 A;  4EA0 A;  4PVX F;  4E1E A;  2Z7I A;  5KSX F;  3KRA B;  5H9D A;  2Z4V A;  4GP1 A;  4FP4 A;  5IK0 A;  3LGZ B;  3WCJ A;  3WCB A;  2ZY1 A;  4NFJ F;  3LGK A;  3ZMB A;  5CG6 A;  2E95 A;  5IL8 A;  4L2X F;  2F94 F;  2ZCO A;  2PS4 A;  5A0K A;  2F7M F;  3ACW A;  3M02 A;  4DHD A;  4LFV F;  1YHM A;  2AZL A;  3KRO A;  3M9U A;  4NFK F;  3WJN A;  5EAS A;  1ZW5 A;  4XQS F;  2O1O A;  4LTV A;  1JFG A;  5E8H A;  2Z50 A;  1V4I A;  4DEM F;  2F92 F;  5B00 A;  4KVW A;  3WCC A;  5ILH A;  1DGP A;  1HXG A;  4LZ3 A;  2VF6 A;  2Q58 A;  1N24 A;  1RQI A;  3M00 A;  1VG6 A;  5IK6 A;  3KRF A;  3SAE A;  2Q80 A;  1YYT A;  2F8Z F;  2AZK A;  3QKC A;  3PYA A;  1YV5 A;  4UMJ A;  2OGD A;  3OYR A;  3SDR A;  4EA2 A;  4DXJ A;  4F6V A;  4OGU A;  1N1B A;  1VG2 A;  1HM7 A;  2PS6 A;  4JVJ F;  4OMH A;  4P0W A;  5HN7 A;  3TS7 A;  5CG5 A;  3OAC A;  2DH4 A;  3P41 A;  2J5C A;  2OPN A;  3WCL A;  5DW7 A;  3AQB B;  1PS1 A;  3WCD A;  3ICM A;  2ZCS A;  2ZEU A;  5HN9 A;  3WEK A;  5JV0 F;  3ICN A;  3CKE A;  4KPJ A;  3NF2 A;  4H5E F;  3N3L F;  4OKM A;  3VJ9 A;  3KRP A;  5B0K A;  5ER8 A;  5IMN A;  1N20 A;  1UBY A;  2E92 A;  5IMP A;  4F6X A;  3PH7 A;  3WCM A;  1YYQ A;  3VJD A;  4H5D F;  5B02 A;  5JV1 F;  3PKO A;  5IKA A;  3KRC B;  4KVD A;  3V1V A;  5ILY A;  3LLW A;  3SDV A;  2Q9Y A;  4FJQ A;  4GAX A;  3BNX A;  3N3D A;  3WEI A;  3DYG A;  5JV2 F;  4LTZ A;  4LFG A;  1N1Z A;  4DWB A;  1DI1 A;  3N1V F;  1HX9 A;  3TC1 A;  4LPG F;  4H5C F;  3LEE A;  5DJV F;  5IN8 A;  3AE0 A;  4WK5 A;  4MC0 A;  2E8V A;  4LXW A;  5B01 A;  3N0G A;  3WEG A;  2E8X A;  2E8W A;  5AFX A;  3EFQ A;  3WJO A;  1V4H A;  3MAV A;  4GA3 A;  2FTZ A;  5IM1 A;  3VJA A;  4DWG A;  2E4O A;  3ADZ A;  3EZ3 A;  1YJ4 A;  1WKZ A;  4RXA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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