4NUAA

The effects of lysine 200 and phenylalanine 239 farnesyl pyrophosphate synthase (fpps) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Total Genus 141
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
342
structure length
338
Chain Sequence
AYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNTIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFAQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords Farnesyl pyrophosphate synthase
publication title The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
rcsb
source organism Homo sapiens
total genus 141
structure length 338
sequence length 342
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2013-12-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4nuaA00
3WCFA 4H5EF 1N21A 5EROA 5AYPA 2Q58A 3M00A 5IMIA 3LVSA 3QKCA 3ID0A 2AEKA 5IMNA 4RXEA 3NPRA 2F89F 4XQTF 1N1BA 1YHKA 2Z50A 5JV0F 2ZEUA 2O1OA 5B02A 3PKOA 3DYGA 1WL3A 2F9KF 4LTVA 2PS4A 4EA1A 3M9UA 1RTRA 1VG6A 1HXCA 3AQ0A 1WL2A 5DGSF 5HN8A 3TFVA 2VF6A 5DZ2A 1VG4A 3ICKA 3PYAA 4LA6A 2Z4XA 3Q1OA 3W7FA 2FTZA 3OABB 5A0KA 3KROA 3NPKA 3RMGA 3WEGA 1HM4A 5IK6A 3APZA 3WJOA 3WEIA 2DH4A 2RAHA 1N1ZA 4OKMA 3PH7A 5JV1F 3N3LF 4RYPA 3B7LA 3SDRA 3N1VF 5HN9A 2ZCRA 3S4JA 5IM1A 3AQCB 3VJ9A 3ZMCA 3VJBA 5ILHA 3KRPB 4H5DF 4LPGF 1UBYA 1UBWA 3NF2A 1WY0A 1YYQA 3PYBA 3WCLA 3S9VA 1PS1A 1N24A 2P1CA 3N45F 1V4KA 3LK5A 1YHLA 3KRAB 1UBVA 3N49F 2AELA 1HXGA 3CP6A 2OA6A 4KUXA 3Q30A 4DXJA 3LSNA 4N1ZF 3ACWA 4HD1A 3M02A 3NRIA 4UMJA 3LDWA 1YV5A 5ER8A 3WC9A 4DZWA 5DJPF 2F7MF 2J1OA 2F8CF 5AHUB 5ILKA 3OABA 4JVJF 2F8ZF 2ZY1A 3LZ9A 3WE9A 5IMPA 3WCHA 3VJAA 5H9DA 3KBKA 2ZEVA 4OKZA 3ACYA 2Z7HA 4KFAA 5DGNF 1N23A 1HM7A 1DI1A 5EASA 4RXAA 5DJRF 5DIQF 3TFNA 1DGPA 2ZCQA 5B0JA 5E8HA 3P8RA 3KRPA 5EAUA 5JA0F 5EATA 4KQSA 4LZ0A 4JXNA 3LOMA 1WL0A 2E8UA 3LMDA 4JYXA 4KQ5A 1HX9A 3KRCB 1V4JA 5IKAA 2Z4ZA 4LFVF 2E8TA 4E9UA 5I1UA 5B0MA 3KRAA 1ZW5A 1WMWA 3IPIA 4NFKF 3AE0A 2E4OA 1YYRA 1KIZA 2J5CA 2E92A 2EWGA 3LG5A 3SDQA 3WEKA 1VG3A 3ZMBA 5B0IA 3N3DA 1JFAA 5IL8A 4P0WA 4L2XF 3V1VA 3SDUA 3ICMA 3CKEA 4ZQ8A 4RXDA 1V4IA 1VG7A 5IL3A 5ILDA 3G4DA 3M0GA 2E94A 1RQJA 3MAVA 4E9ZA 4E1EA 3N46F 4EA2A 2Z78A 5B01A 4H5CF 1HXAA 3N5JF 3VJDA 2F94F 2E8XA 4WK5A 3BNYA 3OACB 3BNXA 4F6XA 3TS7A 3N5HF 2ONHA 2OPMA 3WCGA 4XQRF 4GA3A 3LEEA 1VG2A 4KVDA 3KRCA 1JFGA 2Z4WA 1YYTA 5ERMA 5AELA 4DI5A 4KVWA 2Q9ZA 2E93A 4LZCA 3WJNA 4PVXF 4NKEA 4NFIF 2Q80A 2FORA 4P0XA 1WKZA 4GP1A 3VJ8A 3N6KF 4KK2A 1V4EA 2AETA 5B03A 4QXSF 1N20A 3M01A 4QPFA 1N22A 4LIXA 3N0FA 2H8OA 2Z4VA 4OGUA 3PDEA 3SDTA 3WEHA 4OMHA 5ILYA 3WCCA 5IVGA 1FPSA 4MC0A 2Z4YA 3SAEA 1YHMA 4PVYF 3IBAA 2OGDA 2PS8A 4FJQA 1EZFA 3SDVA 3WCIA 5DW7A 3V66A 3EZ3A 5C05A 4LFGA 3WCEA 3RYWA 3WCDA 3WEJA 3OACA 2E95A 5JV2F 3DYHA 2J1PA 3OYRA 2AZKA 2OPNA 5JUZF 3ASXA 3CC9A 3WSBA 3P41A 4JZBA 4MC8A 4LLTA 4LPHF 5ERNA 5E8LA 4F62A 2ZCOA 4MC3A 3WEFA 3ACXA 3LJIA 4OMGA 5ILIA 4LTZA 3KRFB 4EA0A 3TFPA 4LOBA 5B00A 1YYSA 4LUUA 4LXWA 3LGKA 3P5PA 5IN8A 4JXYA 2Z7IA 2AZLA 3LGZB 5AFXA 5IK9A 3ADZA 3P8LA 4FP4A 2E8WA 4F6VA 2E91A 5CG5A 2F92F 3V1XA 5IKHA 1RQIA 2AZJA 4KVYA 3ZOUA 3WSAA 5DGMF 3MZVA 4GAXA 1YQ7A 3N1WF 4LZ3A 3DYFA 4NG6A 2PS7A 5ILJA 5A0JA 5KSXF 3EFQA 3WCBA 4DWBA 5E8KA 3WJKA 4RXCA 2ZCSA 3AQBB 4P0VA 4N9UA 5DHIA 3ICNA 4GP2A 4LFEA 5ILZA 2E8VA 4NKFA 4KPDA 4LA5A 3UCAA 5CG6A 3KB9A 4JZXA 3ZCDA 4KWDA 4DEMF 3Q2QA 3G4FA 3KRFA 3VJCA 4KKMA 2Q9YA 4KPJA 4DWGA 3N0GA 4KVIA 4NUAA 3ZL6A 3ICZA 4DHDA 3EGTA 2PS5A 5B0LA 4Q23A 5A0IA 3RYEA 3KROB 2ONGA 4RNQA 4NFJF 5IK0A 1KIYA 2PS6A 2I19A 5HN7A 1UBXA 5HNAA 5DHKA 3RBMA 1WL1A 4K10A 5B0KA 5DJVF 1V4HA 1YJ4A 3P5RA 4KQUA 3VJEA 3WCMA 4XQSF 3TC1A 3WCJA 2Z52A 2QISA 3LLWA 2E90A 3Q2ZA 3QQVA 4LLSA 3WCAA 1YYUA
chains in the Genus database with same CATH superfamily
3WCFA 4H5EF 1N21A 5EROA 5AYPA 2Q58A 3M00A 5IMIA 3LVSA 3QKCA 3ID0A 2AEKA 5IMNA 4RXEA 3NPRA 2F89F 4XQTF 1N1BA 1YHKA 2Z50A 5JV0F 2ZEUA 2O1OA 5B02A 3PKOA 3DYGA 1WL3A 2F9KF 4LTVA 2PS4A 4EA1A 3M9UA 1RTRA 1VG6A 1HXCA 3AQ0A 1WL2A 5DGSF 5HN8A 3TFVA 2VF6A 5DZ2A 1VG4A 3ICKA 3PYAA 4LA6A 2Z4XA 3Q1OA 3W7FA 2FTZA 3OABB 5A0KA 3KROA 3NPKA 3RMGA 3WEGA 1HM4A 5IK6A 3APZA 3WJOA 3WEIA 2DH4A 2RAHA 1N1ZA 4OKMA 3PH7A 5JV1F 3N3LF 4RYPA 3B7LA 3SDRA 3N1VF 5HN9A 2ZCRA 3S4JA 5IM1A 3AQCB 3VJ9A 3ZMCA 3VJBA 5ILHA 3KRPB 4H5DF 4LPGF 1UBYA 1UBWA 3NF2A 1WY0A 1YYQA 3PYBA 3WCLA 3S9VA 1PS1A 1N24A 2P1CA 3N45F 1V4KA 3LK5A 1YHLA 3KRAB 1UBVA 3N49F 2AELA 1HXGA 3CP6A 2OA6A 4KUXA 3Q30A 4DXJA 3LSNA 4N1ZF 3ACWA 4HD1A 3M02A 3NRIA 4UMJA 3LDWA 1YV5A 5ER8A 3WC9A 4DZWA 5DJPF 2F7MF 2J1OA 2F8CF 5AHUB 5ILKA 3OABA 4JVJF 2F8ZF 2ZY1A 3LZ9A 3WE9A 5IMPA 3WCHA 3VJAA 5H9DA 3KBKA 2ZEVA 4OKZA 3ACYA 2Z7HA 4KFAA 5DGNF 1N23A 1HM7A 1DI1A 5EASA 4RXAA 5DJRF 5DIQF 3TFNA 1DGPA 2ZCQA 5B0JA 5E8HA 3P8RA 3KRPA 5EAUA 5JA0F 5EATA 4KQSA 4LZ0A 4JXNA 3LOMA 1WL0A 2E8UA 3LMDA 4JYXA 4KQ5A 1HX9A 3KRCB 1V4JA 5IKAA 2Z4ZA 4LFVF 2E8TA 4E9UA 5I1UA 5B0MA 3KRAA 1ZW5A 1WMWA 3IPIA 4NFKF 3AE0A 2E4OA 1YYRA 1KIZA 2J5CA 2E92A 2EWGA 3LG5A 3SDQA 3WEKA 1VG3A 3ZMBA 5B0IA 3N3DA 1JFAA 5IL8A 4P0WA 4L2XF 3V1VA 3SDUA 3ICMA 3CKEA 4ZQ8A 4RXDA 1V4IA 1VG7A 5IL3A 5ILDA 3G4DA 3M0GA 2E94A 1RQJA 3MAVA 4E9ZA 4E1EA 3N46F 4EA2A 2Z78A 5B01A 4H5CF 1HXAA 3N5JF 3VJDA 2F94F 2E8XA 4WK5A 3BNYA 3OACB 3BNXA 4F6XA 3TS7A 3N5HF 2ONHA 2OPMA 3WCGA 4XQRF 4GA3A 3LEEA 1VG2A 4KVDA 3KRCA 1JFGA 2Z4WA 1YYTA 5ERMA 5AELA 4DI5A 4KVWA 2Q9ZA 2E93A 4LZCA 3WJNA 4PVXF 4NKEA 4NFIF 2Q80A 2FORA 4P0XA 1WKZA 4GP1A 3VJ8A 3N6KF 4KK2A 1V4EA 2AETA 5B03A 4QXSF 1N20A 3M01A 4QPFA 1N22A 4LIXA 3N0FA 2H8OA 2Z4VA 4OGUA 3PDEA 3SDTA 3WEHA 4OMHA 5ILYA 3WCCA 5IVGA 1FPSA 4MC0A 2Z4YA 3SAEA 1YHMA 4PVYF 3IBAA 2OGDA 2PS8A 4FJQA 1EZFA 3SDVA 3WCIA 5DW7A 3V66A 3EZ3A 5C05A 4LFGA 3WCEA 3RYWA 3WCDA 3WEJA 3OACA 2E95A 5JV2F 3DYHA 2J1PA 3OYRA 2AZKA 2OPNA 5JUZF 3ASXA 3CC9A 3WSBA 3P41A 4JZBA 4MC8A 4LLTA 4LPHF 5ERNA 5E8LA 4F62A 2ZCOA 4MC3A 3WEFA 3ACXA 3LJIA 4OMGA 5ILIA 4LTZA 3KRFB 4EA0A 3TFPA 4LOBA 5B00A 1YYSA 4LUUA 4LXWA 3LGKA 3P5PA 5IN8A 4JXYA 2Z7IA 2AZLA 3LGZB 5AFXA 5IK9A 3ADZA 3P8LA 4FP4A 2E8WA 4F6VA 2E91A 5CG5A 2F92F 3V1XA 5IKHA 1RQIA 2AZJA 4KVYA 3ZOUA 3WSAA 5DGMF 3MZVA 4GAXA 1YQ7A 3N1WF 4LZ3A 3DYFA 4NG6A 2PS7A 5ILJA 5A0JA 5KSXF 3EFQA 3WCBA 4DWBA 5E8KA 3WJKA 4RXCA 2ZCSA 3AQBB 4P0VA 4N9UA 5DHIA 3ICNA 4GP2A 4LFEA 5ILZA 2E8VA 4NKFA 4KPDA 4LA5A 3UCAA 5CG6A 3KB9A 4JZXA 3ZCDA 4KWDA 4DEMF 3Q2QA 3G4FA 3KRFA 3VJCA 4KKMA 2Q9YA 4KPJA 4DWGA 3N0GA 4KVIA 4NUAA 3ZL6A 3ICZA 4DHDA 3EGTA 2PS5A 5B0LA 4Q23A 5A0IA 3RYEA 3KROB 2ONGA 4RNQA 4NFJF 5IK0A 1KIYA 2PS6A 2I19A 5HN7A 1UBXA 5HNAA 5DHKA 3RBMA 1WL1A 4K10A 5B0KA 5DJVF 1V4HA 1YJ4A 3P5RA 4KQUA 3VJEA 3WCMA 4XQSF 3TC1A 3WCJA 2Z52A 2QISA 3LLWA 2E90A 3Q2ZA 3QQVA 4LLSA 3WCAA 1YYUA
chains in the Genus database with same CATH topology
3WCFA 4H5EF 1N21A 5EROA 5AYPA 2Q58A 3M00A 5IMIA 3LVSA 3QKCA 3ID0A 2AEKA 5IMNA 4RXEA 3NPRA 2F89F 4XQTF 1N1BA 1YHKA 2Z50A 5JV0F 2ZEUA 2O1OA 5B02A 3PKOA 3DYGA 1WL3A 2F9KF 4LTVA 2PS4A 4EA1A 3M9UA 1RTRA 1VG6A 1HXCA 3AQ0A 1WL2A 5DGSF 5HN8A 3TFVA 2VF6A 5DZ2A 1VG4A 3ICKA 3PYAA 4LA6A 2Z4XA 3Q1OA 3W7FA 2FTZA 3OABB 5A0KA 3KROA 3NPKA 3RMGA 3WEGA 1HM4A 5IK6A 3APZA 3WJOA 3WEIA 2DH4A 2RAHA 1N1ZA 4OKMA 3PH7A 5JV1F 3N3LF 4RYPA 3B7LA 3SDRA 3N1VF 5HN9A 2ZCRA 3S4JA 5IM1A 3AQCB 3VJ9A 3ZMCA 3VJBA 5ILHA 3KRPB 4H5DF 4LPGF 1UBYA 1UBWA 3NF2A 1WY0A 1YYQA 3PYBA 3WCLA 3S9VA 1PS1A 1N24A 2P1CA 3N45F 1V4KA 3LK5A 1YHLA 3KRAB 1UBVA 3N49F 2AELA 1HXGA 3CP6A 2OA6A 4KUXA 3Q30A 4DXJA 3LSNA 4N1ZF 3ACWA 4HD1A 3M02A 3NRIA 4UMJA 3LDWA 1YV5A 5ER8A 3WC9A 4DZWA 5DJPF 2F7MF 2J1OA 2F8CF 5AHUB 5ILKA 3OABA 4JVJF 2F8ZF 2ZY1A 3LZ9A 3WE9A 5IMPA 3WCHA 3VJAA 5H9DA 3KBKA 2ZEVA 4OKZA 3ACYA 2Z7HA 4KFAA 5DGNF 1N23A 1HM7A 1DI1A 5EASA 4RXAA 5DJRF 5DIQF 3TFNA 1DGPA 2ZCQA 5B0JA 5E8HA 3P8RA 3KRPA 5EAUA 5JA0F 5EATA 4KQSA 4LZ0A 4JXNA 3LOMA 1WL0A 2E8UA 3LMDA 4JYXA 4KQ5A 1HX9A 3KRCB 1V4JA 5IKAA 2Z4ZA 4LFVF 2E8TA 4E9UA 5I1UA 5B0MA 3KRAA 1ZW5A 1WMWA 3IPIA 4NFKF 3AE0A 2E4OA 1YYRA 1KIZA 2J5CA 2E92A 2EWGA 3LG5A 3SDQA 3WEKA 1VG3A 3ZMBA 5B0IA 3N3DA 1JFAA 5IL8A 4P0WA 4L2XF 3V1VA 3SDUA 3ICMA 3CKEA 4ZQ8A 4RXDA 1V4IA 1VG7A 5IL3A 5ILDA 3G4DA 3M0GA 2E94A 1RQJA 3MAVA 4E9ZA 4E1EA 3N46F 4EA2A 2Z78A 5B01A 4H5CF 1HXAA 3N5JF 3VJDA 2F94F 2E8XA 4WK5A 3BNYA 3OACB 3BNXA 4F6XA 3TS7A 3N5HF 2ONHA 2OPMA 3WCGA 4XQRF 4GA3A 3LEEA 1VG2A 4KVDA 3KRCA 1JFGA 2Z4WA 1YYTA 5ERMA 5AELA 4DI5A 4KVWA 2Q9ZA 2E93A 4LZCA 3WJNA 4PVXF 4NKEA 4NFIF 2Q80A 2FORA 4P0XA 1WKZA 4GP1A 3VJ8A 3N6KF 4KK2A 1V4EA 2AETA 5B03A 4QXSF 1N20A 3M01A 4QPFA 1N22A 4LIXA 3N0FA 2H8OA 2Z4VA 4OGUA 3PDEA 3SDTA 3WEHA 4OMHA 5ILYA 3WCCA 5IVGA 1FPSA 4MC0A 2Z4YA 3SAEA 1YHMA 4PVYF 3IBAA 2OGDA 2PS8A 4FJQA 1EZFA 3SDVA 3WCIA 5DW7A 3V66A 3EZ3A 5C05A 4LFGA 3WCEA 3RYWA 3WCDA 3WEJA 3OACA 2E95A 5JV2F 3DYHA 2J1PA 3OYRA 2AZKA 2OPNA 5JUZF 3ASXA 3CC9A 3WSBA 3P41A 4JZBA 4MC8A 4LLTA 4LPHF 5ERNA 5E8LA 4F62A 2ZCOA 4MC3A 3WEFA 3ACXA 3LJIA 4OMGA 5ILIA 4LTZA 3KRFB 4EA0A 3TFPA 4LOBA 5B00A 1YYSA 4LUUA 4LXWA 3LGKA 3P5PA 5IN8A 4JXYA 2Z7IA 2AZLA 3LGZB 5AFXA 5IK9A 3ADZA 3P8LA 4FP4A 2E8WA 4F6VA 2E91A 5CG5A 2F92F 3V1XA 5IKHA 1RQIA 2AZJA 4KVYA 3ZOUA 3WSAA 5DGMF 3MZVA 4GAXA 1YQ7A 3N1WF 4LZ3A 3DYFA 4NG6A 2PS7A 5ILJA 5A0JA 5KSXF 3EFQA 3WCBA 4DWBA 5E8KA 3WJKA 4RXCA 2ZCSA 3AQBB 4P0VA 4N9UA 5DHIA 3ICNA 4GP2A 4LFEA 5ILZA 2E8VA 4NKFA 4KPDA 4LA5A 3UCAA 5CG6A 3KB9A 4JZXA 3ZCDA 4KWDA 4DEMF 3Q2QA 3G4FA 3KRFA 3VJCA 4KKMA 2Q9YA 4KPJA 4DWGA 3N0GA 4KVIA 4NUAA 3ZL6A 3ICZA 4DHDA 3EGTA 2PS5A 5B0LA 4Q23A 5A0IA 3RYEA 3KROB 2ONGA 4RNQA 4NFJF 5IK0A 1KIYA 2PS6A 2I19A 5HN7A 1UBXA 5HNAA 5DHKA 3RBMA 1WL1A 4K10A 5B0KA 5DJVF 1V4HA 1YJ4A 3P5RA 4KQUA 3VJEA 3WCMA 4XQSF 3TC1A 3WCJA 2Z52A 2QISA 3LLWA 2E90A 3Q2ZA 3QQVA 4LLSA 3WCAA 1YYUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WCF A;  4H5E F;  1N21 A;  5ERO A;  5AYP A;  2Q58 A;  3M00 A;  5IMI A;  3LVS A;  3QKC A;  3ID0 A;  2AEK A;  5IMN A;  4RXE A;  3NPR A;  2F89 F;  4XQT F;  1N1B A;  1YHK A;  2Z50 A;  5JV0 F;  2ZEU A;  2O1O A;  5B02 A;  3PKO A;  3DYG A;  1WL3 A;  2F9K F;  4LTV A;  2PS4 A;  4EA1 A;  3M9U A;  1RTR A;  1VG6 A;  1HXC A;  3AQ0 A;  1WL2 A;  5DGS F;  5HN8 A;  3TFV A;  2VF6 A;  5DZ2 A;  1VG4 A;  3ICK A;  3PYA A;  4LA6 A;  2Z4X A;  3Q1O A;  3W7F A;  2FTZ A;  3OAB B;  5A0K A;  3KRO A;  3NPK A;  3RMG A;  3WEG A;  1HM4 A;  5IK6 A;  3APZ A;  3WJO A;  3WEI A;  2DH4 A;  2RAH A;  1N1Z A;  4OKM A;  3PH7 A;  5JV1 F;  3N3L F;  4RYP A;  3B7L A;  3SDR A;  3N1V F;  5HN9 A;  2ZCR A;  3S4J A;  5IM1 A;  3AQC B;  3VJ9 A;  3ZMC A;  3VJB A;  5ILH A;  3KRP B;  4H5D F;  4LPG F;  1UBY A;  1UBW A;  3NF2 A;  1WY0 A;  1YYQ A;  3PYB A;  3WCL A;  3S9V A;  1PS1 A;  1N24 A;  2P1C A;  3N45 F;  1V4K A;  3LK5 A;  1YHL A;  3KRA B;  1UBV A;  3N49 F;  2AEL A;  1HXG A;  3CP6 A;  2OA6 A;  4KUX A;  3Q30 A;  4DXJ A;  3LSN A;  4N1Z F;  3ACW A;  4HD1 A;  3M02 A;  3NRI A;  4UMJ A;  3LDW A;  1YV5 A;  5ER8 A;  3WC9 A;  4DZW A;  5DJP F;  2F7M F;  2J1O A;  2F8C F;  5AHU B;  5ILK A;  3OAB A;  4JVJ F;  2F8Z F;  2ZY1 A;  3LZ9 A;  3WE9 A;  5IMP A;  3WCH A;  3VJA A;  5H9D A;  3KBK A;  2ZEV A;  4OKZ A;  3ACY A;  2Z7H A;  4KFA A;  5DGN F;  1N23 A;  1HM7 A;  1DI1 A;  5EAS A;  4RXA A;  5DJR F;  5DIQ F;  3TFN A;  1DGP A;  2ZCQ A;  5B0J A;  5E8H A;  3P8R A;  3KRP A;  5EAU A;  5JA0 F;  5EAT A;  4KQS A;  4LZ0 A;  4JXN A;  3LOM A;  1WL0 A;  2E8U A;  3LMD A;  4JYX A;  4KQ5 A;  1HX9 A;  3KRC B;  1V4J A;  5IKA A;  2Z4Z A;  4LFV F;  2E8T A;  4E9U A;  5I1U A;  5B0M A;  3KRA A;  1ZW5 A;  1WMW A;  3IPI A;  4NFK F;  3AE0 A;  2E4O A;  1YYR A;  1KIZ A;  2J5C A;  2E92 A;  2EWG A;  3LG5 A;  3SDQ A;  3WEK A;  1VG3 A;  3ZMB A;  5B0I A;  3N3D A;  1JFA A;  5IL8 A;  4P0W A;  4L2X F;  3V1V A;  3SDU A;  3ICM A;  3CKE A;  4ZQ8 A;  4RXD A;  1V4I A;  1VG7 A;  5IL3 A;  5ILD A;  3G4D A;  3M0G A;  2E94 A;  1RQJ A;  3MAV A;  4E9Z A;  4E1E A;  3N46 F;  4EA2 A;  2Z78 A;  5B01 A;  4H5C F;  1HXA A;  3N5J F;  3VJD A;  2F94 F;  2E8X A;  4WK5 A;  3BNY A;  3OAC B;  3BNX A;  4F6X A;  3TS7 A;  3N5H F;  2ONH A;  2OPM A;  3WCG A;  4XQR F;  4GA3 A;  3LEE A;  1VG2 A;  4KVD A;  3KRC A;  1JFG A;  2Z4W A;  1YYT A;  5ERM A;  5AEL A;  4DI5 A;  4KVW A;  2Q9Z A;  2E93 A;  4LZC A;  3WJN A;  4PVX F;  4NKE A;  4NFI F;  2Q80 A;  2FOR A;  4P0X A;  1WKZ A;  4GP1 A;  3VJ8 A;  3N6K F;  4KK2 A;  1V4E A;  2AET A;  5B03 A;  4QXS F;  1N20 A;  3M01 A;  4QPF A;  1N22 A;  4LIX A;  3N0F A;  2H8O A;  2Z4V A;  4OGU A;  3PDE A;  3SDT A;  3WEH A;  4OMH A;  5ILY A;  3WCC A;  5IVG A;  1FPS A;  4MC0 A;  2Z4Y A;  3SAE A;  1YHM A;  4PVY F;  3IBA A;  2OGD A;  2PS8 A;  4FJQ A;  1EZF A;  3SDV A;  3WCI A;  5DW7 A;  3V66 A;  3EZ3 A;  5C05 A;  4LFG A;  3WCE A;  3RYW A;  3WCD A;  3WEJ A;  3OAC A;  2E95 A;  5JV2 F;  3DYH A;  2J1P A;  3OYR A;  2AZK A;  2OPN A;  5JUZ F;  3ASX A;  3CC9 A;  3WSB A;  3P41 A;  4JZB A;  4MC8 A;  4LLT A;  4LPH F;  5ERN A;  5E8L A;  4F62 A;  2ZCO A;  4MC3 A;  3WEF A;  3ACX A;  3LJI A;  4OMG A;  5ILI A;  4LTZ A;  3KRF B;  4EA0 A;  3TFP A;  4LOB A;  5B00 A;  1YYS A;  4LUU A;  4LXW A;  3LGK A;  3P5P A;  5IN8 A;  4JXY A;  2Z7I A;  2AZL A;  3LGZ B;  5AFX A;  5IK9 A;  3ADZ A;  3P8L A;  4FP4 A;  2E8W A;  4F6V A;  2E91 A;  5CG5 A;  2F92 F;  3V1X A;  5IKH A;  1RQI A;  2AZJ A;  4KVY A;  3ZOU A;  3WSA A;  5DGM F;  3MZV A;  4GAX A;  1YQ7 A;  3N1W F;  4LZ3 A;  3DYF A;  4NG6 A;  2PS7 A;  5ILJ A;  5A0J A;  5KSX F;  3EFQ A;  3WCB A;  4DWB A;  5E8K A;  3WJK A;  4RXC A;  2ZCS A;  3AQB B;  4P0V A;  4N9U A;  5DHI A;  3ICN A;  4GP2 A;  4LFE A;  5ILZ A;  2E8V A;  4NKF A;  4KPD A;  4LA5 A;  3UCA A;  5CG6 A;  3KB9 A;  4JZX A;  3ZCD A;  4KWD A;  4DEM F;  3Q2Q A;  3G4F A;  3KRF A;  3VJC A;  4KKM A;  2Q9Y A;  4KPJ A;  4DWG A;  3N0G A;  4KVI A;  4NUA A;  3ZL6 A;  3ICZ A;  4DHD A;  3EGT A;  2PS5 A;  5B0L A;  4Q23 A;  5A0I A;  3RYE A;  3KRO B;  2ONG A;  4RNQ A;  4NFJ F;  5IK0 A;  1KIY A;  2PS6 A;  2I19 A;  5HN7 A;  1UBX A;  5HNA A;  5DHK A;  3RBM A;  1WL1 A;  4K10 A;  5B0K A;  5DJV F;  1V4H A;  1YJ4 A;  3P5R A;  4KQU A;  3VJE A;  3WCM A;  4XQS F;  3TC1 A;  3WCJ A;  2Z52 A;  2QIS A;  3LLW A;  2E90 A;  3Q2Z A;  3QQV A;  4LLS A;  3WCA A;  1YYU A; 
#chains in the Genus database with same CATH topology
 3WCF A;  4H5E F;  1N21 A;  5ERO A;  5AYP A;  2Q58 A;  3M00 A;  5IMI A;  3LVS A;  3QKC A;  3ID0 A;  2AEK A;  5IMN A;  4RXE A;  3NPR A;  2F89 F;  4XQT F;  1N1B A;  1YHK A;  2Z50 A;  5JV0 F;  2ZEU A;  2O1O A;  5B02 A;  3PKO A;  3DYG A;  1WL3 A;  2F9K F;  4LTV A;  2PS4 A;  4EA1 A;  3M9U A;  1RTR A;  1VG6 A;  1HXC A;  3AQ0 A;  1WL2 A;  5DGS F;  5HN8 A;  3TFV A;  2VF6 A;  5DZ2 A;  1VG4 A;  3ICK A;  3PYA A;  4LA6 A;  2Z4X A;  3Q1O A;  3W7F A;  2FTZ A;  3OAB B;  5A0K A;  3KRO A;  3NPK A;  3RMG A;  3WEG A;  1HM4 A;  5IK6 A;  3APZ A;  3WJO A;  3WEI A;  2DH4 A;  2RAH A;  1N1Z A;  4OKM A;  3PH7 A;  5JV1 F;  3N3L F;  4RYP A;  3B7L A;  3SDR A;  3N1V F;  5HN9 A;  2ZCR A;  3S4J A;  5IM1 A;  3AQC B;  3VJ9 A;  3ZMC A;  3VJB A;  5ILH A;  3KRP B;  4H5D F;  4LPG F;  1UBY A;  1UBW A;  3NF2 A;  1WY0 A;  1YYQ A;  3PYB A;  3WCL A;  3S9V A;  1PS1 A;  1N24 A;  2P1C A;  3N45 F;  1V4K A;  3LK5 A;  1YHL A;  3KRA B;  1UBV A;  3N49 F;  2AEL A;  1HXG A;  3CP6 A;  2OA6 A;  4KUX A;  3Q30 A;  4DXJ A;  3LSN A;  4N1Z F;  3ACW A;  4HD1 A;  3M02 A;  3NRI A;  4UMJ A;  3LDW A;  1YV5 A;  5ER8 A;  3WC9 A;  4DZW A;  5DJP F;  2F7M F;  2J1O A;  2F8C F;  5AHU B;  5ILK A;  3OAB A;  4JVJ F;  2F8Z F;  2ZY1 A;  3LZ9 A;  3WE9 A;  5IMP A;  3WCH A;  3VJA A;  5H9D A;  3KBK A;  2ZEV A;  4OKZ A;  3ACY A;  2Z7H A;  4KFA A;  5DGN F;  1N23 A;  1HM7 A;  1DI1 A;  5EAS A;  4RXA A;  5DJR F;  5DIQ F;  3TFN A;  1DGP A;  2ZCQ A;  5B0J A;  5E8H A;  3P8R A;  3KRP A;  5EAU A;  5JA0 F;  5EAT A;  4KQS A;  4LZ0 A;  4JXN A;  3LOM A;  1WL0 A;  2E8U A;  3LMD A;  4JYX A;  4KQ5 A;  1HX9 A;  3KRC B;  1V4J A;  5IKA A;  2Z4Z A;  4LFV F;  2E8T A;  4E9U A;  5I1U A;  5B0M A;  3KRA A;  1ZW5 A;  1WMW A;  3IPI A;  4NFK F;  3AE0 A;  2E4O A;  1YYR A;  1KIZ A;  2J5C A;  2E92 A;  2EWG A;  3LG5 A;  3SDQ A;  3WEK A;  1VG3 A;  3ZMB A;  5B0I A;  3N3D A;  1JFA A;  5IL8 A;  4P0W A;  4L2X F;  3V1V A;  3SDU A;  3ICM A;  3CKE A;  4ZQ8 A;  4RXD A;  1V4I A;  1VG7 A;  5IL3 A;  5ILD A;  3G4D A;  3M0G A;  2E94 A;  1RQJ A;  3MAV A;  4E9Z A;  4E1E A;  3N46 F;  4EA2 A;  2Z78 A;  5B01 A;  4H5C F;  1HXA A;  3N5J F;  3VJD A;  2F94 F;  2E8X A;  4WK5 A;  3BNY A;  3OAC B;  3BNX A;  4F6X A;  3TS7 A;  3N5H F;  2ONH A;  2OPM A;  3WCG A;  4XQR F;  4GA3 A;  3LEE A;  1VG2 A;  4KVD A;  3KRC A;  1JFG A;  2Z4W A;  1YYT A;  5ERM A;  5AEL A;  4DI5 A;  4KVW A;  2Q9Z A;  2E93 A;  4LZC A;  3WJN A;  4PVX F;  4NKE A;  4NFI F;  2Q80 A;  2FOR A;  4P0X A;  1WKZ A;  4GP1 A;  3VJ8 A;  3N6K F;  4KK2 A;  1V4E A;  2AET A;  5B03 A;  4QXS F;  1N20 A;  3M01 A;  4QPF A;  1N22 A;  4LIX A;  3N0F A;  2H8O A;  2Z4V A;  4OGU A;  3PDE A;  3SDT A;  3WEH A;  4OMH A;  5ILY A;  3WCC A;  5IVG A;  1FPS A;  4MC0 A;  2Z4Y A;  3SAE A;  1YHM A;  4PVY F;  3IBA A;  2OGD A;  2PS8 A;  4FJQ A;  1EZF A;  3SDV A;  3WCI A;  5DW7 A;  3V66 A;  3EZ3 A;  5C05 A;  4LFG A;  3WCE A;  3RYW A;  3WCD A;  3WEJ A;  3OAC A;  2E95 A;  5JV2 F;  3DYH A;  2J1P A;  3OYR A;  2AZK A;  2OPN A;  5JUZ F;  3ASX A;  3CC9 A;  3WSB A;  3P41 A;  4JZB A;  4MC8 A;  4LLT A;  4LPH F;  5ERN A;  5E8L A;  4F62 A;  2ZCO A;  4MC3 A;  3WEF A;  3ACX A;  3LJI A;  4OMG A;  5ILI A;  4LTZ A;  3KRF B;  4EA0 A;  3TFP A;  4LOB A;  5B00 A;  1YYS A;  4LUU A;  4LXW A;  3LGK A;  3P5P A;  5IN8 A;  4JXY A;  2Z7I A;  2AZL A;  3LGZ B;  5AFX A;  5IK9 A;  3ADZ A;  3P8L A;  4FP4 A;  2E8W A;  4F6V A;  2E91 A;  5CG5 A;  2F92 F;  3V1X A;  5IKH A;  1RQI A;  2AZJ A;  4KVY A;  3ZOU A;  3WSA A;  5DGM F;  3MZV A;  4GAX A;  1YQ7 A;  3N1W F;  4LZ3 A;  3DYF A;  4NG6 A;  2PS7 A;  5ILJ A;  5A0J A;  5KSX F;  3EFQ A;  3WCB A;  4DWB A;  5E8K A;  3WJK A;  4RXC A;  2ZCS A;  3AQB B;  4P0V A;  4N9U A;  5DHI A;  3ICN A;  4GP2 A;  4LFE A;  5ILZ A;  2E8V A;  4NKF A;  4KPD A;  4LA5 A;  3UCA A;  5CG6 A;  3KB9 A;  4JZX A;  3ZCD A;  4KWD A;  4DEM F;  3Q2Q A;  3G4F A;  3KRF A;  3VJC A;  4KKM A;  2Q9Y A;  4KPJ A;  4DWG A;  3N0G A;  4KVI A;  4NUA A;  3ZL6 A;  3ICZ A;  4DHD A;  3EGT A;  2PS5 A;  5B0L A;  4Q23 A;  5A0I A;  3RYE A;  3KRO B;  2ONG A;  4RNQ A;  4NFJ F;  5IK0 A;  1KIY A;  2PS6 A;  2I19 A;  5HN7 A;  1UBX A;  5HNA A;  5DHK A;  3RBM A;  1WL1 A;  4K10 A;  5B0K A;  5DJV F;  1V4H A;  1YJ4 A;  3P5R A;  4KQU A;  3VJE A;  3WCM A;  4XQS F;  3TC1 A;  3WCJ A;  2Z52 A;  2QIS A;  3LLW A;  2E90 A;  3Q2Z A;  3QQV A;  4LLS A;  3WCA A;  1YYU A; 
#chains in the Genus database with same CATH homology
 3WCF A;  4H5E F;  1N21 A;  5ERO A;  5AYP A;  2Q58 A;  3M00 A;  5IMI A;  3LVS A;  3QKC A;  3ID0 A;  2AEK A;  5IMN A;  4RXE A;  3NPR A;  2F89 F;  4XQT F;  1N1B A;  1YHK A;  2Z50 A;  5JV0 F;  2ZEU A;  2O1O A;  5B02 A;  3PKO A;  3DYG A;  1WL3 A;  2F9K F;  4LTV A;  2PS4 A;  4EA1 A;  3M9U A;  1RTR A;  1VG6 A;  1HXC A;  3AQ0 A;  1WL2 A;  5DGS F;  5HN8 A;  3TFV A;  2VF6 A;  5DZ2 A;  1VG4 A;  3ICK A;  3PYA A;  4LA6 A;  2Z4X A;  3Q1O A;  3W7F A;  2FTZ A;  3OAB B;  5A0K A;  3KRO A;  3NPK A;  3RMG A;  3WEG A;  1HM4 A;  5IK6 A;  3APZ A;  3WJO A;  3WEI A;  2DH4 A;  2RAH A;  1N1Z A;  4OKM A;  3PH7 A;  5JV1 F;  3N3L F;  4RYP A;  3B7L A;  3SDR A;  3N1V F;  5HN9 A;  2ZCR A;  3S4J A;  5IM1 A;  3AQC B;  3VJ9 A;  3ZMC A;  3VJB A;  5ILH A;  3KRP B;  4H5D F;  4LPG F;  1UBY A;  1UBW A;  3NF2 A;  1WY0 A;  1YYQ A;  3PYB A;  3WCL A;  3S9V A;  1PS1 A;  1N24 A;  2P1C A;  3N45 F;  1V4K A;  3LK5 A;  1YHL A;  3KRA B;  1UBV A;  3N49 F;  2AEL A;  1HXG A;  3CP6 A;  2OA6 A;  4KUX A;  3Q30 A;  4DXJ A;  3LSN A;  4N1Z F;  3ACW A;  4HD1 A;  3M02 A;  3NRI A;  4UMJ A;  3LDW A;  1YV5 A;  5ER8 A;  3WC9 A;  4DZW A;  5DJP F;  2F7M F;  2J1O A;  2F8C F;  5AHU B;  5ILK A;  3OAB A;  4JVJ F;  2F8Z F;  2ZY1 A;  3LZ9 A;  3WE9 A;  5IMP A;  3WCH A;  3VJA A;  5H9D A;  3KBK A;  2ZEV A;  4OKZ A;  3ACY A;  2Z7H A;  4KFA A;  5DGN F;  1N23 A;  1HM7 A;  1DI1 A;  5EAS A;  4RXA A;  5DJR F;  5DIQ F;  3TFN A;  1DGP A;  2ZCQ A;  5B0J A;  5E8H A;  3P8R A;  3KRP A;  5EAU A;  5JA0 F;  5EAT A;  4KQS A;  4LZ0 A;  4JXN A;  3LOM A;  1WL0 A;  2E8U A;  3LMD A;  4JYX A;  4KQ5 A;  1HX9 A;  3KRC B;  1V4J A;  5IKA A;  2Z4Z A;  4LFV F;  2E8T A;  4E9U A;  5I1U A;  5B0M A;  3KRA A;  1ZW5 A;  1WMW A;  3IPI A;  4NFK F;  3AE0 A;  2E4O A;  1YYR A;  1KIZ A;  2J5C A;  2E92 A;  2EWG A;  3LG5 A;  3SDQ A;  3WEK A;  1VG3 A;  3ZMB A;  5B0I A;  3N3D A;  1JFA A;  5IL8 A;  4P0W A;  4L2X F;  3V1V A;  3SDU A;  3ICM A;  3CKE A;  4ZQ8 A;  4RXD A;  1V4I A;  1VG7 A;  5IL3 A;  5ILD A;  3G4D A;  3M0G A;  2E94 A;  1RQJ A;  3MAV A;  4E9Z A;  4E1E A;  3N46 F;  4EA2 A;  2Z78 A;  5B01 A;  4H5C F;  1HXA A;  3N5J F;  3VJD A;  2F94 F;  2E8X A;  4WK5 A;  3BNY A;  3OAC B;  3BNX A;  4F6X A;  3TS7 A;  3N5H F;  2ONH A;  2OPM A;  3WCG A;  4XQR F;  4GA3 A;  3LEE A;  1VG2 A;  4KVD A;  3KRC A;  1JFG A;  2Z4W A;  1YYT A;  5ERM A;  5AEL A;  4DI5 A;  4KVW A;  2Q9Z A;  2E93 A;  4LZC A;  3WJN A;  4PVX F;  4NKE A;  4NFI F;  2Q80 A;  2FOR A;  4P0X A;  1WKZ A;  4GP1 A;  3VJ8 A;  3N6K F;  4KK2 A;  1V4E A;  2AET A;  5B03 A;  4QXS F;  1N20 A;  3M01 A;  4QPF A;  1N22 A;  4LIX A;  3N0F A;  2H8O A;  2Z4V A;  4OGU A;  3PDE A;  3SDT A;  3WEH A;  4OMH A;  5ILY A;  3WCC A;  5IVG A;  1FPS A;  4MC0 A;  2Z4Y A;  3SAE A;  1YHM A;  4PVY F;  3IBA A;  2OGD A;  2PS8 A;  4FJQ A;  1EZF A;  3SDV A;  3WCI A;  5DW7 A;  3V66 A;  3EZ3 A;  5C05 A;  4LFG A;  3WCE A;  3RYW A;  3WCD A;  3WEJ A;  3OAC A;  2E95 A;  5JV2 F;  3DYH A;  2J1P A;  3OYR A;  2AZK A;  2OPN A;  5JUZ F;  3ASX A;  3CC9 A;  3WSB A;  3P41 A;  4JZB A;  4MC8 A;  4LLT A;  4LPH F;  5ERN A;  5E8L A;  4F62 A;  2ZCO A;  4MC3 A;  3WEF A;  3ACX A;  3LJI A;  4OMG A;  5ILI A;  4LTZ A;  3KRF B;  4EA0 A;  3TFP A;  4LOB A;  5B00 A;  1YYS A;  4LUU A;  4LXW A;  3LGK A;  3P5P A;  5IN8 A;  4JXY A;  2Z7I A;  2AZL A;  3LGZ B;  5AFX A;  5IK9 A;  3ADZ A;  3P8L A;  4FP4 A;  2E8W A;  4F6V A;  2E91 A;  5CG5 A;  2F92 F;  3V1X A;  5IKH A;  1RQI A;  2AZJ A;  4KVY A;  3ZOU A;  3WSA A;  5DGM F;  3MZV A;  4GAX A;  1YQ7 A;  3N1W F;  4LZ3 A;  3DYF A;  4NG6 A;  2PS7 A;  5ILJ A;  5A0J A;  5KSX F;  3EFQ A;  3WCB A;  4DWB A;  5E8K A;  3WJK A;  4RXC A;  2ZCS A;  3AQB B;  4P0V A;  4N9U A;  5DHI A;  3ICN A;  4GP2 A;  4LFE A;  5ILZ A;  2E8V A;  4NKF A;  4KPD A;  4LA5 A;  3UCA A;  5CG6 A;  3KB9 A;  4JZX A;  3ZCD A;  4KWD A;  4DEM F;  3Q2Q A;  3G4F A;  3KRF A;  3VJC A;  4KKM A;  2Q9Y A;  4KPJ A;  4DWG A;  3N0G A;  4KVI A;  4NUA A;  3ZL6 A;  3ICZ A;  4DHD A;  3EGT A;  2PS5 A;  5B0L A;  4Q23 A;  5A0I A;  3RYE A;  3KRO B;  2ONG A;  4RNQ A;  4NFJ F;  5IK0 A;  1KIY A;  2PS6 A;  2I19 A;  5HN7 A;  1UBX A;  5HNA A;  5DHK A;  3RBM A;  1WL1 A;  4K10 A;  5B0K A;  5DJV F;  1V4H A;  1YJ4 A;  3P5R A;  4KQU A;  3VJE A;  3WCM A;  4XQS F;  3TC1 A;  3WCJ A;  2Z52 A;  2QIS A;  3LLW A;  2E90 A;  3Q2Z A;  3QQV A;  4LLS A;  3WCA A;  1YYU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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