4E1EA

Crystal structure of trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(n-hexylamino)ethane-1,1-diyl]bisphosphonic acid and mg2+
Total Genus 143
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
143
sequence length
361
structure length
361
Chain Sequence
ASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDKDPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRKK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Trypanosoma cruzi
molecule keywords Farnesyl pyrophosphate synthase
total genus 143
structure length 361
sequence length 361
ec nomenclature ec 2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
pdb deposition date 2012-03-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4e1eA00
5ERNA 1YHLA 1YHMA 3DYFA 5IN8A 5B03A 3RBMA 5EATA 1YV5A 2E8XA 4NFKF 4LUUA 4PVXF 3SAEA 2Z4WA 4ZQ8A 5B0MA 3TS7A 4EA2A 4JZXA 5IL3A 3CKEA 3P8LA 4JXYA 5ILYA 3LSNA 2Z52A 3IPIA 2E93A 4KPDA 3ACYA 1HM4A 1YHKA 3WSBA 4RNQA 3W7FA 2AETA 3P5PA 1WL1A 4NFIF 3OACA 4JYXA 3WCJA 2Z4VA 3KRCB 5DJPF 3SDVA 3N3LF 3WJOA 1N1ZA 1N21A 3ICKA 5IMPA 2E4OA 1RTRA 2O1OA 3V1XA 3KROA 3WCFA 4LZ0A 2AZJA 1YYSA 4OKMA 3SDTA 5EASA 4MC3A 1WY0A 5JA0F 3QKCA 3P8RA 3OYRA 1JFAA 3SDUA 2E94A 2F89F 3LJIA 3LVSA 2PS5A 5DHKA 3VJEA 3ZCDA 3AQCB 4KVYA 5IMNA 5IL8A 3KRFB 2Q9ZA 4L2XF 4NFJF 5JUZF 2F8CF 4LFGA 2E91A 4EA0A 4DWGA 4KFAA 3NRIA 1VG6A 3WCIA 3N0GA 3ADZA 3M00A 3ID0A 3KRPA 2E8UA 4NUAA 4RXDA 2J1OA 3WEGA 2F94F 3M01A 1UBXA 1WL2A 2J1PA 4H5CF 1VG3A 2Z4XA 5JV0F 4OGUA 1N1BA 5H9DA 4GP1A 5KSXF 3DYGA 1YYTA 3WEIA 5HNAA 4GAXA 1DI1A 2J5CA 3WEFA 5IK6A 5JV2F 4FJQA 3PDEA 5DZ2A 4DZWA 4LOBA 3NF2A 4H5EF 3ZL6A 3N46F 3WEKA 4MC8A 3LEEA 3UCAA 3OABB 5B00A 4LLSA 5EROA 5C05A 3VJDA 3OACB 5DGNF 3RYWA 4LA5A 2F8ZF 5B0LA 2FTZA 5ERMA 3WCDA 5E8LA 3KROB 5DIQF 3LK5A 3LGZB 4LTVA 5IMIA 4F6VA 4HD1A 2OPNA 5CG6A 3WCCA 5HN8A 1V4KA 2Z4YA 4QXSF 3OABA 5JV1F 2OPMA 2PS6A 4P0VA 5CG5A 4LFEA 3LMDA 3Q2QA 4FP4A 1VG4A 2DH4A 5IVGA 3LG5A 4KQ5A 5DGSF 4LIXA 4JZBA 1RQJA 3WCMA 5DHIA 4F6XA 3AQ0A 1WKZA 3PYBA 3APZA 5ER8A 3TFVA 1EZFA 4LFVF 5HN9A 3G4FA 3KRPB 3P5RA 2PS4A 2Z7IA 4KKMA 4MC0A 4LTZA 5IK9A 4LPHF 4XQSF 3RYEA 2EWGA 2PS8A 2ZEUA 4LZ3A 3NPRA 2P1CA 5I1UA 3ZOUA 5IKHA 4KQSA 3MAVA 3WC9A 3KBKA 3LDWA 4KVIA 5E8HA 3N1WF 1UBYA 3M9UA 2ZCSA 4NKEA 3ZMCA 3EFQA 3LZ9A 2Q80A 4OMGA 3V66A 5IKAA 5DJVF 2OA6A 4EA1A 1HXAA 4N9UA 3CP6A 3Q2ZA 3LLWA 3V1VA 3WEJA 5ILZA 3ICMA 1WL0A 3VJCA 1PS1A 2E8VA 2ONHA 3WCBA 3KRAB 5ILHA 4LA6A 3ZMBA 5AFXA 4P0XA 5DW7A 1HXCA 4KWDA 5A0IA 3NPKA 3S4JA 1HXGA 3ICNA 4NG6A 4DEMF 4KK2A 4GP2A 2F92F 2E8WA 3N6KF 2F7MF 4RXCA 5A0JA 4LPGF 1N22A 4XQTF 1WMWA 2Z4ZA 2AZKA 5ILIA 4E1EA 3ICZA 4UMJA 2RAHA 3VJAA 3KRAA 2F9KF 4F62A 1UBWA 5DGMF 2AELA 1UBVA 3VJ8A 3LGKA 3TC1A 4PVYF 3PH7A 4LZCA 1V4EA 2ZCOA 4LXWA 2PS7A 3Q1OA 3WCHA 2E95A 1DGPA 4LLTA 3N0FA 2ONGA 1KIZA 4KPJA 4NKFA 4DXJA 3ACWA 1VG7A 3WCLA 3M02A 4N1ZF 1JFGA 3N5JF 3TFPA 2AZLA 3M0GA 3BNYA 3KB9A 1ZW5A 3WJNA 1YJ4A 5AELA 1N23A 4KQUA 3WSAA 5E8KA 2E92A 4Q23A 2I19A 2OGDA 3G4DA 3PKOA 4H5DF 3N1VF 3RMGA 2ZEVA 5IM1A 3LOMA 1HM7A 2Q58A 3QQVA 5B0JA 1YQ7A 1YYRA 2ZCRA 4DI5A 3AE0A 4KVWA 1FPSA 2ZY1A 5DJRF 3WE9A 2Q9YA 4WK5A 2E90A 1V4IA 2FORA 3ASXA 5AYPA 2ZCQA 3TFNA 3EGTA 3EZ3A 4E9UA 5AHUB 5B0KA 1YYQA 4QPFA 3BNXA 2QISA 3DYHA 3N5HF 3N49F 3WCGA 4P0WA 3N3DA 3P41A 1VG2A 4GA3A 2AEKA 3KRCA 4E9ZA 5B0IA 3SDRA 2Z7HA 1N24A 5ILJA 2Z50A 3N45F 5HN7A 4KVDA 3Q30A 3VJ9A 5EAUA 3WCAA 1YYUA 4RXAA 4K10A 1N20A 3VJBA 4XQRF 3WCEA 1V4HA 1RQIA 5IK0A 4JVJF 2E8TA 4OMHA 5ILKA 2VF6A 4RXEA 3PYAA 4DHDA 3ACXA 3CC9A 4OKZA 4KUXA 4JXNA 3KRFA 1KIYA 3WEHA 5B01A 2Z78A 4DWBA 3AQBB 1V4JA 5B02A 3IBAA 1WL3A 4RYPA 3B7LA 2H8OA 5A0KA 3S9VA 1HX9A 3SDQA 3WJKA 5ILDA 3MZVA
chains in the Genus database with same CATH superfamily
5ERNA 1YHLA 1YHMA 3DYFA 5IN8A 5B03A 3RBMA 5EATA 1YV5A 2E8XA 4NFKF 4LUUA 4PVXF 3SAEA 2Z4WA 4ZQ8A 5B0MA 3TS7A 4EA2A 4JZXA 5IL3A 3CKEA 3P8LA 4JXYA 5ILYA 3LSNA 2Z52A 3IPIA 2E93A 4KPDA 3ACYA 1HM4A 1YHKA 3WSBA 4RNQA 3W7FA 2AETA 3P5PA 1WL1A 4NFIF 3OACA 4JYXA 3WCJA 2Z4VA 3KRCB 5DJPF 3SDVA 3N3LF 3WJOA 1N1ZA 1N21A 3ICKA 5IMPA 2E4OA 1RTRA 2O1OA 3V1XA 3KROA 3WCFA 4LZ0A 2AZJA 1YYSA 4OKMA 3SDTA 5EASA 4MC3A 1WY0A 5JA0F 3QKCA 3P8RA 3OYRA 1JFAA 3SDUA 2E94A 2F89F 3LJIA 3LVSA 2PS5A 5DHKA 3VJEA 3ZCDA 3AQCB 4KVYA 5IMNA 5IL8A 3KRFB 2Q9ZA 4L2XF 4NFJF 5JUZF 2F8CF 4LFGA 2E91A 4EA0A 4DWGA 4KFAA 3NRIA 1VG6A 3WCIA 3N0GA 3ADZA 3M00A 3ID0A 3KRPA 2E8UA 4NUAA 4RXDA 2J1OA 3WEGA 2F94F 3M01A 1UBXA 1WL2A 2J1PA 4H5CF 1VG3A 2Z4XA 5JV0F 4OGUA 1N1BA 5H9DA 4GP1A 5KSXF 3DYGA 1YYTA 3WEIA 5HNAA 4GAXA 1DI1A 2J5CA 3WEFA 5IK6A 5JV2F 4FJQA 3PDEA 5DZ2A 4DZWA 4LOBA 3NF2A 4H5EF 3ZL6A 3N46F 3WEKA 4MC8A 3LEEA 3UCAA 3OABB 5B00A 4LLSA 5EROA 5C05A 3VJDA 3OACB 5DGNF 3RYWA 4LA5A 2F8ZF 5B0LA 2FTZA 5ERMA 3WCDA 5E8LA 3KROB 5DIQF 3LK5A 3LGZB 4LTVA 5IMIA 4F6VA 4HD1A 2OPNA 5CG6A 3WCCA 5HN8A 1V4KA 2Z4YA 4QXSF 3OABA 5JV1F 2OPMA 2PS6A 4P0VA 5CG5A 4LFEA 3LMDA 3Q2QA 4FP4A 1VG4A 2DH4A 5IVGA 3LG5A 4KQ5A 5DGSF 4LIXA 4JZBA 1RQJA 3WCMA 5DHIA 4F6XA 3AQ0A 1WKZA 3PYBA 3APZA 5ER8A 3TFVA 1EZFA 4LFVF 5HN9A 3G4FA 3KRPB 3P5RA 2PS4A 2Z7IA 4KKMA 4MC0A 4LTZA 5IK9A 4LPHF 4XQSF 3RYEA 2EWGA 2PS8A 2ZEUA 4LZ3A 3NPRA 2P1CA 5I1UA 3ZOUA 5IKHA 4KQSA 3MAVA 3WC9A 3KBKA 3LDWA 4KVIA 5E8HA 3N1WF 1UBYA 3M9UA 2ZCSA 4NKEA 3ZMCA 3EFQA 3LZ9A 2Q80A 4OMGA 3V66A 5IKAA 5DJVF 2OA6A 4EA1A 1HXAA 4N9UA 3CP6A 3Q2ZA 3LLWA 3V1VA 3WEJA 5ILZA 3ICMA 1WL0A 3VJCA 1PS1A 2E8VA 2ONHA 3WCBA 3KRAB 5ILHA 4LA6A 3ZMBA 5AFXA 4P0XA 5DW7A 1HXCA 4KWDA 5A0IA 3NPKA 3S4JA 1HXGA 3ICNA 4NG6A 4DEMF 4KK2A 4GP2A 2F92F 2E8WA 3N6KF 2F7MF 4RXCA 5A0JA 4LPGF 1N22A 4XQTF 1WMWA 2Z4ZA 2AZKA 5ILIA 4E1EA 3ICZA 4UMJA 2RAHA 3VJAA 3KRAA 2F9KF 4F62A 1UBWA 5DGMF 2AELA 1UBVA 3VJ8A 3LGKA 3TC1A 4PVYF 3PH7A 4LZCA 1V4EA 2ZCOA 4LXWA 2PS7A 3Q1OA 3WCHA 2E95A 1DGPA 4LLTA 3N0FA 2ONGA 1KIZA 4KPJA 4NKFA 4DXJA 3ACWA 1VG7A 3WCLA 3M02A 4N1ZF 1JFGA 3N5JF 3TFPA 2AZLA 3M0GA 3BNYA 3KB9A 1ZW5A 3WJNA 1YJ4A 5AELA 1N23A 4KQUA 3WSAA 5E8KA 2E92A 4Q23A 2I19A 2OGDA 3G4DA 3PKOA 4H5DF 3N1VF 3RMGA 2ZEVA 5IM1A 3LOMA 1HM7A 2Q58A 3QQVA 5B0JA 1YQ7A 1YYRA 2ZCRA 4DI5A 3AE0A 4KVWA 1FPSA 2ZY1A 5DJRF 3WE9A 2Q9YA 4WK5A 2E90A 1V4IA 2FORA 3ASXA 5AYPA 2ZCQA 3TFNA 3EGTA 3EZ3A 4E9UA 5AHUB 5B0KA 1YYQA 4QPFA 3BNXA 2QISA 3DYHA 3N5HF 3N49F 3WCGA 4P0WA 3N3DA 3P41A 1VG2A 4GA3A 2AEKA 3KRCA 4E9ZA 5B0IA 3SDRA 2Z7HA 1N24A 5ILJA 2Z50A 3N45F 5HN7A 4KVDA 3Q30A 3VJ9A 5EAUA 3WCAA 1YYUA 4RXAA 4K10A 1N20A 3VJBA 4XQRF 3WCEA 1V4HA 1RQIA 5IK0A 4JVJF 2E8TA 4OMHA 5ILKA 2VF6A 4RXEA 3PYAA 4DHDA 3ACXA 3CC9A 4OKZA 4KUXA 4JXNA 3KRFA 1KIYA 3WEHA 5B01A 2Z78A 4DWBA 3AQBB 1V4JA 5B02A 3IBAA 1WL3A 4RYPA 3B7LA 2H8OA 5A0KA 3S9VA 1HX9A 3SDQA 3WJKA 5ILDA 3MZVA
chains in the Genus database with same CATH topology
5ERNA 1YHLA 1YHMA 3DYFA 5IN8A 5B03A 3RBMA 5EATA 1YV5A 2E8XA 4NFKF 4LUUA 4PVXF 3SAEA 2Z4WA 4ZQ8A 5B0MA 3TS7A 4EA2A 4JZXA 5IL3A 3CKEA 3P8LA 4JXYA 5ILYA 3LSNA 2Z52A 3IPIA 2E93A 4KPDA 3ACYA 1HM4A 1YHKA 3WSBA 4RNQA 3W7FA 2AETA 3P5PA 1WL1A 4NFIF 3OACA 4JYXA 3WCJA 2Z4VA 3KRCB 5DJPF 3SDVA 3N3LF 3WJOA 1N1ZA 1N21A 3ICKA 5IMPA 2E4OA 1RTRA 2O1OA 3V1XA 3KROA 3WCFA 4LZ0A 2AZJA 1YYSA 4OKMA 3SDTA 5EASA 4MC3A 1WY0A 5JA0F 3QKCA 3P8RA 3OYRA 1JFAA 3SDUA 2E94A 2F89F 3LJIA 3LVSA 2PS5A 5DHKA 3VJEA 3ZCDA 3AQCB 4KVYA 5IMNA 5IL8A 3KRFB 2Q9ZA 4L2XF 4NFJF 5JUZF 2F8CF 4LFGA 2E91A 4EA0A 4DWGA 4KFAA 3NRIA 1VG6A 3WCIA 3N0GA 3ADZA 3M00A 3ID0A 3KRPA 2E8UA 4NUAA 4RXDA 2J1OA 3WEGA 2F94F 3M01A 1UBXA 1WL2A 2J1PA 4H5CF 1VG3A 2Z4XA 5JV0F 4OGUA 1N1BA 5H9DA 4GP1A 5KSXF 3DYGA 1YYTA 3WEIA 5HNAA 4GAXA 1DI1A 2J5CA 3WEFA 5IK6A 5JV2F 4FJQA 3PDEA 5DZ2A 4DZWA 4LOBA 3NF2A 4H5EF 3ZL6A 3N46F 3WEKA 4MC8A 3LEEA 3UCAA 3OABB 5B00A 4LLSA 5EROA 5C05A 3VJDA 3OACB 5DGNF 3RYWA 4LA5A 2F8ZF 5B0LA 2FTZA 5ERMA 3WCDA 5E8LA 3KROB 5DIQF 3LK5A 3LGZB 4LTVA 5IMIA 4F6VA 4HD1A 2OPNA 5CG6A 3WCCA 5HN8A 1V4KA 2Z4YA 4QXSF 3OABA 5JV1F 2OPMA 2PS6A 4P0VA 5CG5A 4LFEA 3LMDA 3Q2QA 4FP4A 1VG4A 2DH4A 5IVGA 3LG5A 4KQ5A 5DGSF 4LIXA 4JZBA 1RQJA 3WCMA 5DHIA 4F6XA 3AQ0A 1WKZA 3PYBA 3APZA 5ER8A 3TFVA 1EZFA 4LFVF 5HN9A 3G4FA 3KRPB 3P5RA 2PS4A 2Z7IA 4KKMA 4MC0A 4LTZA 5IK9A 4LPHF 4XQSF 3RYEA 2EWGA 2PS8A 2ZEUA 4LZ3A 3NPRA 2P1CA 5I1UA 3ZOUA 5IKHA 4KQSA 3MAVA 3WC9A 3KBKA 3LDWA 4KVIA 5E8HA 3N1WF 1UBYA 3M9UA 2ZCSA 4NKEA 3ZMCA 3EFQA 3LZ9A 2Q80A 4OMGA 3V66A 5IKAA 5DJVF 2OA6A 4EA1A 1HXAA 4N9UA 3CP6A 3Q2ZA 3LLWA 3V1VA 3WEJA 5ILZA 3ICMA 1WL0A 3VJCA 1PS1A 2E8VA 2ONHA 3WCBA 3KRAB 5ILHA 4LA6A 3ZMBA 5AFXA 4P0XA 5DW7A 1HXCA 4KWDA 5A0IA 3NPKA 3S4JA 1HXGA 3ICNA 4NG6A 4DEMF 4KK2A 4GP2A 2F92F 2E8WA 3N6KF 2F7MF 4RXCA 5A0JA 4LPGF 1N22A 4XQTF 1WMWA 2Z4ZA 2AZKA 5ILIA 4E1EA 3ICZA 4UMJA 2RAHA 3VJAA 3KRAA 2F9KF 4F62A 1UBWA 5DGMF 2AELA 1UBVA 3VJ8A 3LGKA 3TC1A 4PVYF 3PH7A 4LZCA 1V4EA 2ZCOA 4LXWA 2PS7A 3Q1OA 3WCHA 2E95A 1DGPA 4LLTA 3N0FA 2ONGA 1KIZA 4KPJA 4NKFA 4DXJA 3ACWA 1VG7A 3WCLA 3M02A 4N1ZF 1JFGA 3N5JF 3TFPA 2AZLA 3M0GA 3BNYA 3KB9A 1ZW5A 3WJNA 1YJ4A 5AELA 1N23A 4KQUA 3WSAA 5E8KA 2E92A 4Q23A 2I19A 2OGDA 3G4DA 3PKOA 4H5DF 3N1VF 3RMGA 2ZEVA 5IM1A 3LOMA 1HM7A 2Q58A 3QQVA 5B0JA 1YQ7A 1YYRA 2ZCRA 4DI5A 3AE0A 4KVWA 1FPSA 2ZY1A 5DJRF 3WE9A 2Q9YA 4WK5A 2E90A 1V4IA 2FORA 3ASXA 5AYPA 2ZCQA 3TFNA 3EGTA 3EZ3A 4E9UA 5AHUB 5B0KA 1YYQA 4QPFA 3BNXA 2QISA 3DYHA 3N5HF 3N49F 3WCGA 4P0WA 3N3DA 3P41A 1VG2A 4GA3A 2AEKA 3KRCA 4E9ZA 5B0IA 3SDRA 2Z7HA 1N24A 5ILJA 2Z50A 3N45F 5HN7A 4KVDA 3Q30A 3VJ9A 5EAUA 3WCAA 1YYUA 4RXAA 4K10A 1N20A 3VJBA 4XQRF 3WCEA 1V4HA 1RQIA 5IK0A 4JVJF 2E8TA 4OMHA 5ILKA 2VF6A 4RXEA 3PYAA 4DHDA 3ACXA 3CC9A 4OKZA 4KUXA 4JXNA 3KRFA 1KIYA 3WEHA 5B01A 2Z78A 4DWBA 3AQBB 1V4JA 5B02A 3IBAA 1WL3A 4RYPA 3B7LA 2H8OA 5A0KA 3S9VA 1HX9A 3SDQA 3WJKA 5ILDA 3MZVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5ERN A;  1YHL A;  1YHM A;  3DYF A;  5IN8 A;  5B03 A;  3RBM A;  5EAT A;  1YV5 A;  2E8X A;  4NFK F;  4LUU A;  4PVX F;  3SAE A;  2Z4W A;  4ZQ8 A;  5B0M A;  3TS7 A;  4EA2 A;  4JZX A;  5IL3 A;  3CKE A;  3P8L A;  4JXY A;  5ILY A;  3LSN A;  2Z52 A;  3IPI A;  2E93 A;  4KPD A;  3ACY A;  1HM4 A;  1YHK A;  3WSB A;  4RNQ A;  3W7F A;  2AET A;  3P5P A;  1WL1 A;  4NFI F;  3OAC A;  4JYX A;  3WCJ A;  2Z4V A;  3KRC B;  5DJP F;  3SDV A;  3N3L F;  3WJO A;  1N1Z A;  1N21 A;  3ICK A;  5IMP A;  2E4O A;  1RTR A;  2O1O A;  3V1X A;  3KRO A;  3WCF A;  4LZ0 A;  2AZJ A;  1YYS A;  4OKM A;  3SDT A;  5EAS A;  4MC3 A;  1WY0 A;  5JA0 F;  3QKC A;  3P8R A;  3OYR A;  1JFA A;  3SDU A;  2E94 A;  2F89 F;  3LJI A;  3LVS A;  2PS5 A;  5DHK A;  3VJE A;  3ZCD A;  3AQC B;  4KVY A;  5IMN A;  5IL8 A;  3KRF B;  2Q9Z A;  4L2X F;  4NFJ F;  5JUZ F;  2F8C F;  4LFG A;  2E91 A;  4EA0 A;  4DWG A;  4KFA A;  3NRI A;  1VG6 A;  3WCI A;  3N0G A;  3ADZ A;  3M00 A;  3ID0 A;  3KRP A;  2E8U A;  4NUA A;  4RXD A;  2J1O A;  3WEG A;  2F94 F;  3M01 A;  1UBX A;  1WL2 A;  2J1P A;  4H5C F;  1VG3 A;  2Z4X A;  5JV0 F;  4OGU A;  1N1B A;  5H9D A;  4GP1 A;  5KSX F;  3DYG A;  1YYT A;  3WEI A;  5HNA A;  4GAX A;  1DI1 A;  2J5C A;  3WEF A;  5IK6 A;  5JV2 F;  4FJQ A;  3PDE A;  5DZ2 A;  4DZW A;  4LOB A;  3NF2 A;  4H5E F;  3ZL6 A;  3N46 F;  3WEK A;  4MC8 A;  3LEE A;  3UCA A;  3OAB B;  5B00 A;  4LLS A;  5ERO A;  5C05 A;  3VJD A;  3OAC B;  5DGN F;  3RYW A;  4LA5 A;  2F8Z F;  5B0L A;  2FTZ A;  5ERM A;  3WCD A;  5E8L A;  3KRO B;  5DIQ F;  3LK5 A;  3LGZ B;  4LTV A;  5IMI A;  4F6V A;  4HD1 A;  2OPN A;  5CG6 A;  3WCC A;  5HN8 A;  1V4K A;  2Z4Y A;  4QXS F;  3OAB A;  5JV1 F;  2OPM A;  2PS6 A;  4P0V A;  5CG5 A;  4LFE A;  3LMD A;  3Q2Q A;  4FP4 A;  1VG4 A;  2DH4 A;  5IVG A;  3LG5 A;  4KQ5 A;  5DGS F;  4LIX A;  4JZB A;  1RQJ A;  3WCM A;  5DHI A;  4F6X A;  3AQ0 A;  1WKZ A;  3PYB A;  3APZ A;  5ER8 A;  3TFV A;  1EZF A;  4LFV F;  5HN9 A;  3G4F A;  3KRP B;  3P5R A;  2PS4 A;  2Z7I A;  4KKM A;  4MC0 A;  4LTZ A;  5IK9 A;  4LPH F;  4XQS F;  3RYE A;  2EWG A;  2PS8 A;  2ZEU A;  4LZ3 A;  3NPR A;  2P1C A;  5I1U A;  3ZOU A;  5IKH A;  4KQS A;  3MAV A;  3WC9 A;  3KBK A;  3LDW A;  4KVI A;  5E8H A;  3N1W F;  1UBY A;  3M9U A;  2ZCS A;  4NKE A;  3ZMC A;  3EFQ A;  3LZ9 A;  2Q80 A;  4OMG A;  3V66 A;  5IKA A;  5DJV F;  2OA6 A;  4EA1 A;  1HXA A;  4N9U A;  3CP6 A;  3Q2Z A;  3LLW A;  3V1V A;  3WEJ A;  5ILZ A;  3ICM A;  1WL0 A;  3VJC A;  1PS1 A;  2E8V A;  2ONH A;  3WCB A;  3KRA B;  5ILH A;  4LA6 A;  3ZMB A;  5AFX A;  4P0X A;  5DW7 A;  1HXC A;  4KWD A;  5A0I A;  3NPK A;  3S4J A;  1HXG A;  3ICN A;  4NG6 A;  4DEM F;  4KK2 A;  4GP2 A;  2F92 F;  2E8W A;  3N6K F;  2F7M F;  4RXC A;  5A0J A;  4LPG F;  1N22 A;  4XQT F;  1WMW A;  2Z4Z A;  2AZK A;  5ILI A;  4E1E A;  3ICZ A;  4UMJ A;  2RAH A;  3VJA A;  3KRA A;  2F9K F;  4F62 A;  1UBW A;  5DGM F;  2AEL A;  1UBV A;  3VJ8 A;  3LGK A;  3TC1 A;  4PVY F;  3PH7 A;  4LZC A;  1V4E A;  2ZCO A;  4LXW A;  2PS7 A;  3Q1O A;  3WCH A;  2E95 A;  1DGP A;  4LLT A;  3N0F A;  2ONG A;  1KIZ A;  4KPJ A;  4NKF A;  4DXJ A;  3ACW A;  1VG7 A;  3WCL A;  3M02 A;  4N1Z F;  1JFG A;  3N5J F;  3TFP A;  2AZL A;  3M0G A;  3BNY A;  3KB9 A;  1ZW5 A;  3WJN A;  1YJ4 A;  5AEL A;  1N23 A;  4KQU A;  3WSA A;  5E8K A;  2E92 A;  4Q23 A;  2I19 A;  2OGD A;  3G4D A;  3PKO A;  4H5D F;  3N1V F;  3RMG A;  2ZEV A;  5IM1 A;  3LOM A;  1HM7 A;  2Q58 A;  3QQV A;  5B0J A;  1YQ7 A;  1YYR A;  2ZCR A;  4DI5 A;  3AE0 A;  4KVW A;  1FPS A;  2ZY1 A;  5DJR F;  3WE9 A;  2Q9Y A;  4WK5 A;  2E90 A;  1V4I A;  2FOR A;  3ASX A;  5AYP A;  2ZCQ A;  3TFN A;  3EGT A;  3EZ3 A;  4E9U A;  5AHU B;  5B0K A;  1YYQ A;  4QPF A;  3BNX A;  2QIS A;  3DYH A;  3N5H F;  3N49 F;  3WCG A;  4P0W A;  3N3D A;  3P41 A;  1VG2 A;  4GA3 A;  2AEK A;  3KRC A;  4E9Z A;  5B0I A;  3SDR A;  2Z7H A;  1N24 A;  5ILJ A;  2Z50 A;  3N45 F;  5HN7 A;  4KVD A;  3Q30 A;  3VJ9 A;  5EAU A;  3WCA A;  1YYU A;  4RXA A;  4K10 A;  1N20 A;  3VJB A;  4XQR F;  3WCE A;  1V4H A;  1RQI A;  5IK0 A;  4JVJ F;  2E8T A;  4OMH A;  5ILK A;  2VF6 A;  4RXE A;  3PYA A;  4DHD A;  3ACX A;  3CC9 A;  4OKZ A;  4KUX A;  4JXN A;  3KRF A;  1KIY A;  3WEH A;  5B01 A;  2Z78 A;  4DWB A;  3AQB B;  1V4J A;  5B02 A;  3IBA A;  1WL3 A;  4RYP A;  3B7L A;  2H8O A;  5A0K A;  3S9V A;  1HX9 A;  3SDQ A;  3WJK A;  5ILD A;  3MZV A; 
#chains in the Genus database with same CATH topology
 5ERN A;  1YHL A;  1YHM A;  3DYF A;  5IN8 A;  5B03 A;  3RBM A;  5EAT A;  1YV5 A;  2E8X A;  4NFK F;  4LUU A;  4PVX F;  3SAE A;  2Z4W A;  4ZQ8 A;  5B0M A;  3TS7 A;  4EA2 A;  4JZX A;  5IL3 A;  3CKE A;  3P8L A;  4JXY A;  5ILY A;  3LSN A;  2Z52 A;  3IPI A;  2E93 A;  4KPD A;  3ACY A;  1HM4 A;  1YHK A;  3WSB A;  4RNQ A;  3W7F A;  2AET A;  3P5P A;  1WL1 A;  4NFI F;  3OAC A;  4JYX A;  3WCJ A;  2Z4V A;  3KRC B;  5DJP F;  3SDV A;  3N3L F;  3WJO A;  1N1Z A;  1N21 A;  3ICK A;  5IMP A;  2E4O A;  1RTR A;  2O1O A;  3V1X A;  3KRO A;  3WCF A;  4LZ0 A;  2AZJ A;  1YYS A;  4OKM A;  3SDT A;  5EAS A;  4MC3 A;  1WY0 A;  5JA0 F;  3QKC A;  3P8R A;  3OYR A;  1JFA A;  3SDU A;  2E94 A;  2F89 F;  3LJI A;  3LVS A;  2PS5 A;  5DHK A;  3VJE A;  3ZCD A;  3AQC B;  4KVY A;  5IMN A;  5IL8 A;  3KRF B;  2Q9Z A;  4L2X F;  4NFJ F;  5JUZ F;  2F8C F;  4LFG A;  2E91 A;  4EA0 A;  4DWG A;  4KFA A;  3NRI A;  1VG6 A;  3WCI A;  3N0G A;  3ADZ A;  3M00 A;  3ID0 A;  3KRP A;  2E8U A;  4NUA A;  4RXD A;  2J1O A;  3WEG A;  2F94 F;  3M01 A;  1UBX A;  1WL2 A;  2J1P A;  4H5C F;  1VG3 A;  2Z4X A;  5JV0 F;  4OGU A;  1N1B A;  5H9D A;  4GP1 A;  5KSX F;  3DYG A;  1YYT A;  3WEI A;  5HNA A;  4GAX A;  1DI1 A;  2J5C A;  3WEF A;  5IK6 A;  5JV2 F;  4FJQ A;  3PDE A;  5DZ2 A;  4DZW A;  4LOB A;  3NF2 A;  4H5E F;  3ZL6 A;  3N46 F;  3WEK A;  4MC8 A;  3LEE A;  3UCA A;  3OAB B;  5B00 A;  4LLS A;  5ERO A;  5C05 A;  3VJD A;  3OAC B;  5DGN F;  3RYW A;  4LA5 A;  2F8Z F;  5B0L A;  2FTZ A;  5ERM A;  3WCD A;  5E8L A;  3KRO B;  5DIQ F;  3LK5 A;  3LGZ B;  4LTV A;  5IMI A;  4F6V A;  4HD1 A;  2OPN A;  5CG6 A;  3WCC A;  5HN8 A;  1V4K A;  2Z4Y A;  4QXS F;  3OAB A;  5JV1 F;  2OPM A;  2PS6 A;  4P0V A;  5CG5 A;  4LFE A;  3LMD A;  3Q2Q A;  4FP4 A;  1VG4 A;  2DH4 A;  5IVG A;  3LG5 A;  4KQ5 A;  5DGS F;  4LIX A;  4JZB A;  1RQJ A;  3WCM A;  5DHI A;  4F6X A;  3AQ0 A;  1WKZ A;  3PYB A;  3APZ A;  5ER8 A;  3TFV A;  1EZF A;  4LFV F;  5HN9 A;  3G4F A;  3KRP B;  3P5R A;  2PS4 A;  2Z7I A;  4KKM A;  4MC0 A;  4LTZ A;  5IK9 A;  4LPH F;  4XQS F;  3RYE A;  2EWG A;  2PS8 A;  2ZEU A;  4LZ3 A;  3NPR A;  2P1C A;  5I1U A;  3ZOU A;  5IKH A;  4KQS A;  3MAV A;  3WC9 A;  3KBK A;  3LDW A;  4KVI A;  5E8H A;  3N1W F;  1UBY A;  3M9U A;  2ZCS A;  4NKE A;  3ZMC A;  3EFQ A;  3LZ9 A;  2Q80 A;  4OMG A;  3V66 A;  5IKA A;  5DJV F;  2OA6 A;  4EA1 A;  1HXA A;  4N9U A;  3CP6 A;  3Q2Z A;  3LLW A;  3V1V A;  3WEJ A;  5ILZ A;  3ICM A;  1WL0 A;  3VJC A;  1PS1 A;  2E8V A;  2ONH A;  3WCB A;  3KRA B;  5ILH A;  4LA6 A;  3ZMB A;  5AFX A;  4P0X A;  5DW7 A;  1HXC A;  4KWD A;  5A0I A;  3NPK A;  3S4J A;  1HXG A;  3ICN A;  4NG6 A;  4DEM F;  4KK2 A;  4GP2 A;  2F92 F;  2E8W A;  3N6K F;  2F7M F;  4RXC A;  5A0J A;  4LPG F;  1N22 A;  4XQT F;  1WMW A;  2Z4Z A;  2AZK A;  5ILI A;  4E1E A;  3ICZ A;  4UMJ A;  2RAH A;  3VJA A;  3KRA A;  2F9K F;  4F62 A;  1UBW A;  5DGM F;  2AEL A;  1UBV A;  3VJ8 A;  3LGK A;  3TC1 A;  4PVY F;  3PH7 A;  4LZC A;  1V4E A;  2ZCO A;  4LXW A;  2PS7 A;  3Q1O A;  3WCH A;  2E95 A;  1DGP A;  4LLT A;  3N0F A;  2ONG A;  1KIZ A;  4KPJ A;  4NKF A;  4DXJ A;  3ACW A;  1VG7 A;  3WCL A;  3M02 A;  4N1Z F;  1JFG A;  3N5J F;  3TFP A;  2AZL A;  3M0G A;  3BNY A;  3KB9 A;  1ZW5 A;  3WJN A;  1YJ4 A;  5AEL A;  1N23 A;  4KQU A;  3WSA A;  5E8K A;  2E92 A;  4Q23 A;  2I19 A;  2OGD A;  3G4D A;  3PKO A;  4H5D F;  3N1V F;  3RMG A;  2ZEV A;  5IM1 A;  3LOM A;  1HM7 A;  2Q58 A;  3QQV A;  5B0J A;  1YQ7 A;  1YYR A;  2ZCR A;  4DI5 A;  3AE0 A;  4KVW A;  1FPS A;  2ZY1 A;  5DJR F;  3WE9 A;  2Q9Y A;  4WK5 A;  2E90 A;  1V4I A;  2FOR A;  3ASX A;  5AYP A;  2ZCQ A;  3TFN A;  3EGT A;  3EZ3 A;  4E9U A;  5AHU B;  5B0K A;  1YYQ A;  4QPF A;  3BNX A;  2QIS A;  3DYH A;  3N5H F;  3N49 F;  3WCG A;  4P0W A;  3N3D A;  3P41 A;  1VG2 A;  4GA3 A;  2AEK A;  3KRC A;  4E9Z A;  5B0I A;  3SDR A;  2Z7H A;  1N24 A;  5ILJ A;  2Z50 A;  3N45 F;  5HN7 A;  4KVD A;  3Q30 A;  3VJ9 A;  5EAU A;  3WCA A;  1YYU A;  4RXA A;  4K10 A;  1N20 A;  3VJB A;  4XQR F;  3WCE A;  1V4H A;  1RQI A;  5IK0 A;  4JVJ F;  2E8T A;  4OMH A;  5ILK A;  2VF6 A;  4RXE A;  3PYA A;  4DHD A;  3ACX A;  3CC9 A;  4OKZ A;  4KUX A;  4JXN A;  3KRF A;  1KIY A;  3WEH A;  5B01 A;  2Z78 A;  4DWB A;  3AQB B;  1V4J A;  5B02 A;  3IBA A;  1WL3 A;  4RYP A;  3B7L A;  2H8O A;  5A0K A;  3S9V A;  1HX9 A;  3SDQ A;  3WJK A;  5ILD A;  3MZV A; 
#chains in the Genus database with same CATH homology
 5ERN A;  1YHL A;  1YHM A;  3DYF A;  5IN8 A;  5B03 A;  3RBM A;  5EAT A;  1YV5 A;  2E8X A;  4NFK F;  4LUU A;  4PVX F;  3SAE A;  2Z4W A;  4ZQ8 A;  5B0M A;  3TS7 A;  4EA2 A;  4JZX A;  5IL3 A;  3CKE A;  3P8L A;  4JXY A;  5ILY A;  3LSN A;  2Z52 A;  3IPI A;  2E93 A;  4KPD A;  3ACY A;  1HM4 A;  1YHK A;  3WSB A;  4RNQ A;  3W7F A;  2AET A;  3P5P A;  1WL1 A;  4NFI F;  3OAC A;  4JYX A;  3WCJ A;  2Z4V A;  3KRC B;  5DJP F;  3SDV A;  3N3L F;  3WJO A;  1N1Z A;  1N21 A;  3ICK A;  5IMP A;  2E4O A;  1RTR A;  2O1O A;  3V1X A;  3KRO A;  3WCF A;  4LZ0 A;  2AZJ A;  1YYS A;  4OKM A;  3SDT A;  5EAS A;  4MC3 A;  1WY0 A;  5JA0 F;  3QKC A;  3P8R A;  3OYR A;  1JFA A;  3SDU A;  2E94 A;  2F89 F;  3LJI A;  3LVS A;  2PS5 A;  5DHK A;  3VJE A;  3ZCD A;  3AQC B;  4KVY A;  5IMN A;  5IL8 A;  3KRF B;  2Q9Z A;  4L2X F;  4NFJ F;  5JUZ F;  2F8C F;  4LFG A;  2E91 A;  4EA0 A;  4DWG A;  4KFA A;  3NRI A;  1VG6 A;  3WCI A;  3N0G A;  3ADZ A;  3M00 A;  3ID0 A;  3KRP A;  2E8U A;  4NUA A;  4RXD A;  2J1O A;  3WEG A;  2F94 F;  3M01 A;  1UBX A;  1WL2 A;  2J1P A;  4H5C F;  1VG3 A;  2Z4X A;  5JV0 F;  4OGU A;  1N1B A;  5H9D A;  4GP1 A;  5KSX F;  3DYG A;  1YYT A;  3WEI A;  5HNA A;  4GAX A;  1DI1 A;  2J5C A;  3WEF A;  5IK6 A;  5JV2 F;  4FJQ A;  3PDE A;  5DZ2 A;  4DZW A;  4LOB A;  3NF2 A;  4H5E F;  3ZL6 A;  3N46 F;  3WEK A;  4MC8 A;  3LEE A;  3UCA A;  3OAB B;  5B00 A;  4LLS A;  5ERO A;  5C05 A;  3VJD A;  3OAC B;  5DGN F;  3RYW A;  4LA5 A;  2F8Z F;  5B0L A;  2FTZ A;  5ERM A;  3WCD A;  5E8L A;  3KRO B;  5DIQ F;  3LK5 A;  3LGZ B;  4LTV A;  5IMI A;  4F6V A;  4HD1 A;  2OPN A;  5CG6 A;  3WCC A;  5HN8 A;  1V4K A;  2Z4Y A;  4QXS F;  3OAB A;  5JV1 F;  2OPM A;  2PS6 A;  4P0V A;  5CG5 A;  4LFE A;  3LMD A;  3Q2Q A;  4FP4 A;  1VG4 A;  2DH4 A;  5IVG A;  3LG5 A;  4KQ5 A;  5DGS F;  4LIX A;  4JZB A;  1RQJ A;  3WCM A;  5DHI A;  4F6X A;  3AQ0 A;  1WKZ A;  3PYB A;  3APZ A;  5ER8 A;  3TFV A;  1EZF A;  4LFV F;  5HN9 A;  3G4F A;  3KRP B;  3P5R A;  2PS4 A;  2Z7I A;  4KKM A;  4MC0 A;  4LTZ A;  5IK9 A;  4LPH F;  4XQS F;  3RYE A;  2EWG A;  2PS8 A;  2ZEU A;  4LZ3 A;  3NPR A;  2P1C A;  5I1U A;  3ZOU A;  5IKH A;  4KQS A;  3MAV A;  3WC9 A;  3KBK A;  3LDW A;  4KVI A;  5E8H A;  3N1W F;  1UBY A;  3M9U A;  2ZCS A;  4NKE A;  3ZMC A;  3EFQ A;  3LZ9 A;  2Q80 A;  4OMG A;  3V66 A;  5IKA A;  5DJV F;  2OA6 A;  4EA1 A;  1HXA A;  4N9U A;  3CP6 A;  3Q2Z A;  3LLW A;  3V1V A;  3WEJ A;  5ILZ A;  3ICM A;  1WL0 A;  3VJC A;  1PS1 A;  2E8V A;  2ONH A;  3WCB A;  3KRA B;  5ILH A;  4LA6 A;  3ZMB A;  5AFX A;  4P0X A;  5DW7 A;  1HXC A;  4KWD A;  5A0I A;  3NPK A;  3S4J A;  1HXG A;  3ICN A;  4NG6 A;  4DEM F;  4KK2 A;  4GP2 A;  2F92 F;  2E8W A;  3N6K F;  2F7M F;  4RXC A;  5A0J A;  4LPG F;  1N22 A;  4XQT F;  1WMW A;  2Z4Z A;  2AZK A;  5ILI A;  4E1E A;  3ICZ A;  4UMJ A;  2RAH A;  3VJA A;  3KRA A;  2F9K F;  4F62 A;  1UBW A;  5DGM F;  2AEL A;  1UBV A;  3VJ8 A;  3LGK A;  3TC1 A;  4PVY F;  3PH7 A;  4LZC A;  1V4E A;  2ZCO A;  4LXW A;  2PS7 A;  3Q1O A;  3WCH A;  2E95 A;  1DGP A;  4LLT A;  3N0F A;  2ONG A;  1KIZ A;  4KPJ A;  4NKF A;  4DXJ A;  3ACW A;  1VG7 A;  3WCL A;  3M02 A;  4N1Z F;  1JFG A;  3N5J F;  3TFP A;  2AZL A;  3M0G A;  3BNY A;  3KB9 A;  1ZW5 A;  3WJN A;  1YJ4 A;  5AEL A;  1N23 A;  4KQU A;  3WSA A;  5E8K A;  2E92 A;  4Q23 A;  2I19 A;  2OGD A;  3G4D A;  3PKO A;  4H5D F;  3N1V F;  3RMG A;  2ZEV A;  5IM1 A;  3LOM A;  1HM7 A;  2Q58 A;  3QQV A;  5B0J A;  1YQ7 A;  1YYR A;  2ZCR A;  4DI5 A;  3AE0 A;  4KVW A;  1FPS A;  2ZY1 A;  5DJR F;  3WE9 A;  2Q9Y A;  4WK5 A;  2E90 A;  1V4I A;  2FOR A;  3ASX A;  5AYP A;  2ZCQ A;  3TFN A;  3EGT A;  3EZ3 A;  4E9U A;  5AHU B;  5B0K A;  1YYQ A;  4QPF A;  3BNX A;  2QIS A;  3DYH A;  3N5H F;  3N49 F;  3WCG A;  4P0W A;  3N3D A;  3P41 A;  1VG2 A;  4GA3 A;  2AEK A;  3KRC A;  4E9Z A;  5B0I A;  3SDR A;  2Z7H A;  1N24 A;  5ILJ A;  2Z50 A;  3N45 F;  5HN7 A;  4KVD A;  3Q30 A;  3VJ9 A;  5EAU A;  3WCA A;  1YYU A;  4RXA A;  4K10 A;  1N20 A;  3VJB A;  4XQR F;  3WCE A;  1V4H A;  1RQI A;  5IK0 A;  4JVJ F;  2E8T A;  4OMH A;  5ILK A;  2VF6 A;  4RXE A;  3PYA A;  4DHD A;  3ACX A;  3CC9 A;  4OKZ A;  4KUX A;  4JXN A;  3KRF A;  1KIY A;  3WEH A;  5B01 A;  2Z78 A;  4DWB A;  3AQB B;  1V4J A;  5B02 A;  3IBA A;  1WL3 A;  4RYP A;  3B7L A;  2H8O A;  5A0K A;  3S9V A;  1HX9 A;  3SDQ A;  3WJK A;  5ILD A;  3MZV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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