4NKEA

The effects of lysine 200 and phenylalanine 239 farnesyl pyrophosphate synthase (fpps) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Total Genus 138
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
138
sequence length
342
structure length
338
Chain Sequence
VYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNTIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFAQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords Farnesyl pyrophosphate synthase
publication title The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
rcsb
source organism Homo sapiens
total genus 138
structure length 338
sequence length 342
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2013-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4nkeA00
2J1OA 4NKFA 3ZCDA 2O1OA 5B00A 1KIZA 1DGPA 3M01A 1V4KA 2PS4A 5ILJA 3P8LA 5AFXA 4XQSF 5AYPA 3QKCA 3P5RA 3W7FA 5ILYA 3N45F 2Q58A 2E93A 1UBWA 3PYAA 1FPSA 1WY0A 4JXNA 3VJ9A 4LUUA 5EATA 3PKOA 2Z4VA 2E90A 5AHUB 3ICNA 3N5HF 4P0WA 4LOBA 4E9ZA 5ILKA 4HD1A 5HN7A 3WCDA 5B01A 5E8LA 3WCAA 4MC8A 3EFQA 3G4DA 1RTRA 1RQJA 3Q2ZA 3WJOA 3RBMA 2P1CA 1YV5A 3M02A 4JVJF 2E8VA 2Z7HA 3BNYA 5JA0F 4DHDA 3VJAA 4F62A 3B7LA 4LZCA 1VG6A 4FP4A 1UBXA 3PDEA 5IMPA 2PS7A 3SDRA 4DEMF 5ILIA 4F6XA 5ILZA 3M00A 1YYSA 4KVWA 5IL8A 5IK9A 2Z50A 5JV2F 1YHKA 2OGDA 3ICZA 3LJIA 5DJRF 4DI5A 5B02A 2Z4YA 3WCJA 4GAXA 3LG5A 3LSNA 5DGNF 4LPHF 3KRPA 4OMHA 2F94F 2ZCSA 1WMWA 5IVGA 2J1PA 3Q30A 2E91A 4WK5A 4DWGA 4XQTF 4LTVA 3AQBB 3ZMBA 3WCMA 1KIYA 1UBVA 2E8WA 5AELA 4KKMA 3WJKA 1V4IA 3CKEA 3UCAA 3V1VA 5A0IA 1N20A 2ZCRA 1JFAA 3ASXA 3KB9A 2Z78A 3WCFA 3N0FA 3SDQA 4EA1A 2E8XA 4KVYA 3KRCB 4LA5A 3WEHA 2H8OA 4GP1A 5EASA 3BNXA 2J5CA 5IMIA 3WCEA 3KROB 3WEKA 1EZFA 3WCGA 1N21A 3SAEA 1WL3A 3QQVA 4KWDA 3V66A 4KUXA 3KRFB 3TC1A 5DW7A 3M9UA 4GP2A 4KQSA 1YJ4A 4Q23A 2ZEVA 4KPDA 3SDTA 3EGTA 4RXEA 5CG5A 4P0VA 1YQ7A 2F89F 3RMGA 5JUZF 2PS5A 5DHIA 3VJDA 2Z52A 3S4JA 5E8HA 4N9UA 3WEFA 2OA6A 3WC9A 5B0LA 3APZA 5B0IA 2Q9ZA 4LA6A 3ACXA 3WEGA 5H9DA 5DIQF 3CP6A 5DZ2A 3KRAB 1RQIA 1N22A 4OMGA 3WCIA 4NUAA 3CC9A 3N3LF 1YHLA 5HNAA 3ICKA 2Q9YA 3KRCA 3ZL6A 3RYEA 3OACB 3VJEA 1HM4A 2PS8A 3P8RA 4JYXA 4OGUA 5ILDA 1HXGA 2E94A 1V4HA 2DH4A 2ZY1A 3KROA 1VG2A 1YHMA 3N3DA 5IM1A 1ZW5A 4KPJA 3ACWA 1HM7A 3KRFA 4ZQ8A 5IKAA 1V4JA 5I1UA 1YYQA 2AETA 4L2XF 3SDVA 2OPNA 3N1WF 3TFNA 3ID0A 3DYGA 4RYPA 3TFPA 2AZLA 5CG6A 4JXYA 3WE9A 4LLSA 2VF6A 1HXCA 2EWGA 1JFGA 1WL2A 4LXWA 5ILHA 4KFAA 2FORA 1N1BA 3RYWA 1N1ZA 2ONHA 3KBKA 3ICMA 3LGZB 4NG6A 3N46F 2PS6A 1WL1A 2ZCQA 5EROA 3N1VF 5IN8A 2F9KF 4MC3A 4LFVF 4E9UA 3OACA 2F92F 3NPKA 4NKEA 3MZVA 2E4OA 2ZCOA 3OYRA 5IKHA 3NRIA 3VJ8A 2AZKA 4QPFA 5A0JA 4NFKF 4LZ3A 3WJNA 3NPRA 5IK6A 3ADZA 3WSAA 4H5DF 4LLTA 3ZMCA 3P5PA 4LPGF 4LTZA 3TS7A 3ACYA 3LLWA 4FJQA 4N1ZF 4H5CF 3DYHA 2E92A 4OKMA 3M0GA 4KQ5A 5B0MA 3WCLA 2I19A 2RAHA 4PVYF 2ZEUA 3WCBA 5DHKA 3N0GA 3VJCA 3ZOUA 3VJBA 4RXAA 4K10A 4LIXA 3NF2A 4UMJA 5KSXF 3G4FA 3EZ3A 4NFJF 3V1XA 1WKZA 2Q80A 5B0KA 5JV0F 1YYTA 3KRPB 1YYRA 5C05A 1DI1A 4P0XA 2QISA 3LDWA 5B03A 3LZ9A 1VG7A 3SDUA 4RNQA 2Z4XA 4KK2A 3N49F 3LOMA 3LGKA 3LK5A 5E8KA 2AZJA 3Q1OA 3AE0A 1N23A 3LEEA 5DJPF 4JZBA 4KVIA 5ER8A 3IBAA 5JV1F 1HXAA 2E8TA 2Z4ZA 5HN8A 3TFVA 3S9VA 1HX9A 4NFIF 4RXCA 3OABB 1VG4A 4LZ0A 4RXDA 3WCHA 1PS1A 5IL3A 4QXSF 3WCCA 3WEJA 1WL0A 3N6KF 1N24A 2F8CF 4PVXF 2F8ZF 3KRAA 3AQ0A 2AELA 4XQRF 5ERNA 4LFGA 2E8UA 4EA0A 5DGSF 1YYUA 4DZWA 3IPIA 1UBYA 4MC0A 2OPMA 3LVSA 4KQUA 2ONGA 2Z4WA 3Q2QA 5IMNA 2F7MF 5IK0A 4OKZA 3WEIA 4E1EA 3PYBA 4LFEA 3LMDA 3AQCB 4JZXA 3N5JF 4GA3A 5EAUA 5ERMA 3DYFA 2Z7IA 5B0JA 2FTZA 4H5EF 4DWBA 4EA2A 3MAVA 3WSBA 5DGMF 3OABA 1VG3A 4F6VA 5HN9A 3P41A 2E95A 4KVDA 4DXJA 5DJVF 5A0KA 2AEKA 1V4EA 3PH7A
chains in the Genus database with same CATH superfamily
2J1OA 4NKFA 3ZCDA 2O1OA 5B00A 1KIZA 1DGPA 3M01A 1V4KA 2PS4A 5ILJA 3P8LA 5AFXA 4XQSF 5AYPA 3QKCA 3P5RA 3W7FA 5ILYA 3N45F 2Q58A 2E93A 1UBWA 3PYAA 1FPSA 1WY0A 4JXNA 3VJ9A 4LUUA 5EATA 3PKOA 2Z4VA 2E90A 5AHUB 3ICNA 3N5HF 4P0WA 4LOBA 4E9ZA 5ILKA 4HD1A 5HN7A 3WCDA 5B01A 5E8LA 3WCAA 4MC8A 3EFQA 3G4DA 1RTRA 1RQJA 3Q2ZA 3WJOA 3RBMA 2P1CA 1YV5A 3M02A 4JVJF 2E8VA 2Z7HA 3BNYA 5JA0F 4DHDA 3VJAA 4F62A 3B7LA 4LZCA 1VG6A 4FP4A 1UBXA 3PDEA 5IMPA 2PS7A 3SDRA 4DEMF 5ILIA 4F6XA 5ILZA 3M00A 1YYSA 4KVWA 5IL8A 5IK9A 2Z50A 5JV2F 1YHKA 2OGDA 3ICZA 3LJIA 5DJRF 4DI5A 5B02A 2Z4YA 3WCJA 4GAXA 3LG5A 3LSNA 5DGNF 4LPHF 3KRPA 4OMHA 2F94F 2ZCSA 1WMWA 5IVGA 2J1PA 3Q30A 2E91A 4WK5A 4DWGA 4XQTF 4LTVA 3AQBB 3ZMBA 3WCMA 1KIYA 1UBVA 2E8WA 5AELA 4KKMA 3WJKA 1V4IA 3CKEA 3UCAA 3V1VA 5A0IA 1N20A 2ZCRA 1JFAA 3ASXA 3KB9A 2Z78A 3WCFA 3N0FA 3SDQA 4EA1A 2E8XA 4KVYA 3KRCB 4LA5A 3WEHA 2H8OA 4GP1A 5EASA 3BNXA 2J5CA 5IMIA 3WCEA 3KROB 3WEKA 1EZFA 3WCGA 1N21A 3SAEA 1WL3A 3QQVA 4KWDA 3V66A 4KUXA 3KRFB 3TC1A 5DW7A 3M9UA 4GP2A 4KQSA 1YJ4A 4Q23A 2ZEVA 4KPDA 3SDTA 3EGTA 4RXEA 5CG5A 4P0VA 1YQ7A 2F89F 3RMGA 5JUZF 2PS5A 5DHIA 3VJDA 2Z52A 3S4JA 5E8HA 4N9UA 3WEFA 2OA6A 3WC9A 5B0LA 3APZA 5B0IA 2Q9ZA 4LA6A 3ACXA 3WEGA 5H9DA 5DIQF 3CP6A 5DZ2A 3KRAB 1RQIA 1N22A 4OMGA 3WCIA 4NUAA 3CC9A 3N3LF 1YHLA 5HNAA 3ICKA 2Q9YA 3KRCA 3ZL6A 3RYEA 3OACB 3VJEA 1HM4A 2PS8A 3P8RA 4JYXA 4OGUA 5ILDA 1HXGA 2E94A 1V4HA 2DH4A 2ZY1A 3KROA 1VG2A 1YHMA 3N3DA 5IM1A 1ZW5A 4KPJA 3ACWA 1HM7A 3KRFA 4ZQ8A 5IKAA 1V4JA 5I1UA 1YYQA 2AETA 4L2XF 3SDVA 2OPNA 3N1WF 3TFNA 3ID0A 3DYGA 4RYPA 3TFPA 2AZLA 5CG6A 4JXYA 3WE9A 4LLSA 2VF6A 1HXCA 2EWGA 1JFGA 1WL2A 4LXWA 5ILHA 4KFAA 2FORA 1N1BA 3RYWA 1N1ZA 2ONHA 3KBKA 3ICMA 3LGZB 4NG6A 3N46F 2PS6A 1WL1A 2ZCQA 5EROA 3N1VF 5IN8A 2F9KF 4MC3A 4LFVF 4E9UA 3OACA 2F92F 3NPKA 4NKEA 3MZVA 2E4OA 2ZCOA 3OYRA 5IKHA 3NRIA 3VJ8A 2AZKA 4QPFA 5A0JA 4NFKF 4LZ3A 3WJNA 3NPRA 5IK6A 3ADZA 3WSAA 4H5DF 4LLTA 3ZMCA 3P5PA 4LPGF 4LTZA 3TS7A 3ACYA 3LLWA 4FJQA 4N1ZF 4H5CF 3DYHA 2E92A 4OKMA 3M0GA 4KQ5A 5B0MA 3WCLA 2I19A 2RAHA 4PVYF 2ZEUA 3WCBA 5DHKA 3N0GA 3VJCA 3ZOUA 3VJBA 4RXAA 4K10A 4LIXA 3NF2A 4UMJA 5KSXF 3G4FA 3EZ3A 4NFJF 3V1XA 1WKZA 2Q80A 5B0KA 5JV0F 1YYTA 3KRPB 1YYRA 5C05A 1DI1A 4P0XA 2QISA 3LDWA 5B03A 3LZ9A 1VG7A 3SDUA 4RNQA 2Z4XA 4KK2A 3N49F 3LOMA 3LGKA 3LK5A 5E8KA 2AZJA 3Q1OA 3AE0A 1N23A 3LEEA 5DJPF 4JZBA 4KVIA 5ER8A 3IBAA 5JV1F 1HXAA 2E8TA 2Z4ZA 5HN8A 3TFVA 3S9VA 1HX9A 4NFIF 4RXCA 3OABB 1VG4A 4LZ0A 4RXDA 3WCHA 1PS1A 5IL3A 4QXSF 3WCCA 3WEJA 1WL0A 3N6KF 1N24A 2F8CF 4PVXF 2F8ZF 3KRAA 3AQ0A 2AELA 4XQRF 5ERNA 4LFGA 2E8UA 4EA0A 5DGSF 1YYUA 4DZWA 3IPIA 1UBYA 4MC0A 2OPMA 3LVSA 4KQUA 2ONGA 2Z4WA 3Q2QA 5IMNA 2F7MF 5IK0A 4OKZA 3WEIA 4E1EA 3PYBA 4LFEA 3LMDA 3AQCB 4JZXA 3N5JF 4GA3A 5EAUA 5ERMA 3DYFA 2Z7IA 5B0JA 2FTZA 4H5EF 4DWBA 4EA2A 3MAVA 3WSBA 5DGMF 3OABA 1VG3A 4F6VA 5HN9A 3P41A 2E95A 4KVDA 4DXJA 5DJVF 5A0KA 2AEKA 1V4EA 3PH7A
chains in the Genus database with same CATH topology
2J1OA 4NKFA 3ZCDA 2O1OA 5B00A 1KIZA 1DGPA 3M01A 1V4KA 2PS4A 5ILJA 3P8LA 5AFXA 4XQSF 5AYPA 3QKCA 3P5RA 3W7FA 5ILYA 3N45F 2Q58A 2E93A 1UBWA 3PYAA 1FPSA 1WY0A 4JXNA 3VJ9A 4LUUA 5EATA 3PKOA 2Z4VA 2E90A 5AHUB 3ICNA 3N5HF 4P0WA 4LOBA 4E9ZA 5ILKA 4HD1A 5HN7A 3WCDA 5B01A 5E8LA 3WCAA 4MC8A 3EFQA 3G4DA 1RTRA 1RQJA 3Q2ZA 3WJOA 3RBMA 2P1CA 1YV5A 3M02A 4JVJF 2E8VA 2Z7HA 3BNYA 5JA0F 4DHDA 3VJAA 4F62A 3B7LA 4LZCA 1VG6A 4FP4A 1UBXA 3PDEA 5IMPA 2PS7A 3SDRA 4DEMF 5ILIA 4F6XA 5ILZA 3M00A 1YYSA 4KVWA 5IL8A 5IK9A 2Z50A 5JV2F 1YHKA 2OGDA 3ICZA 3LJIA 5DJRF 4DI5A 5B02A 2Z4YA 3WCJA 4GAXA 3LG5A 3LSNA 5DGNF 4LPHF 3KRPA 4OMHA 2F94F 2ZCSA 1WMWA 5IVGA 2J1PA 3Q30A 2E91A 4WK5A 4DWGA 4XQTF 4LTVA 3AQBB 3ZMBA 3WCMA 1KIYA 1UBVA 2E8WA 5AELA 4KKMA 3WJKA 1V4IA 3CKEA 3UCAA 3V1VA 5A0IA 1N20A 2ZCRA 1JFAA 3ASXA 3KB9A 2Z78A 3WCFA 3N0FA 3SDQA 4EA1A 2E8XA 4KVYA 3KRCB 4LA5A 3WEHA 2H8OA 4GP1A 5EASA 3BNXA 2J5CA 5IMIA 3WCEA 3KROB 3WEKA 1EZFA 3WCGA 1N21A 3SAEA 1WL3A 3QQVA 4KWDA 3V66A 4KUXA 3KRFB 3TC1A 5DW7A 3M9UA 4GP2A 4KQSA 1YJ4A 4Q23A 2ZEVA 4KPDA 3SDTA 3EGTA 4RXEA 5CG5A 4P0VA 1YQ7A 2F89F 3RMGA 5JUZF 2PS5A 5DHIA 3VJDA 2Z52A 3S4JA 5E8HA 4N9UA 3WEFA 2OA6A 3WC9A 5B0LA 3APZA 5B0IA 2Q9ZA 4LA6A 3ACXA 3WEGA 5H9DA 5DIQF 3CP6A 5DZ2A 3KRAB 1RQIA 1N22A 4OMGA 3WCIA 4NUAA 3CC9A 3N3LF 1YHLA 5HNAA 3ICKA 2Q9YA 3KRCA 3ZL6A 3RYEA 3OACB 3VJEA 1HM4A 2PS8A 3P8RA 4JYXA 4OGUA 5ILDA 1HXGA 2E94A 1V4HA 2DH4A 2ZY1A 3KROA 1VG2A 1YHMA 3N3DA 5IM1A 1ZW5A 4KPJA 3ACWA 1HM7A 3KRFA 4ZQ8A 5IKAA 1V4JA 5I1UA 1YYQA 2AETA 4L2XF 3SDVA 2OPNA 3N1WF 3TFNA 3ID0A 3DYGA 4RYPA 3TFPA 2AZLA 5CG6A 4JXYA 3WE9A 4LLSA 2VF6A 1HXCA 2EWGA 1JFGA 1WL2A 4LXWA 5ILHA 4KFAA 2FORA 1N1BA 3RYWA 1N1ZA 2ONHA 3KBKA 3ICMA 3LGZB 4NG6A 3N46F 2PS6A 1WL1A 2ZCQA 5EROA 3N1VF 5IN8A 2F9KF 4MC3A 4LFVF 4E9UA 3OACA 2F92F 3NPKA 4NKEA 3MZVA 2E4OA 2ZCOA 3OYRA 5IKHA 3NRIA 3VJ8A 2AZKA 4QPFA 5A0JA 4NFKF 4LZ3A 3WJNA 3NPRA 5IK6A 3ADZA 3WSAA 4H5DF 4LLTA 3ZMCA 3P5PA 4LPGF 4LTZA 3TS7A 3ACYA 3LLWA 4FJQA 4N1ZF 4H5CF 3DYHA 2E92A 4OKMA 3M0GA 4KQ5A 5B0MA 3WCLA 2I19A 2RAHA 4PVYF 2ZEUA 3WCBA 5DHKA 3N0GA 3VJCA 3ZOUA 3VJBA 4RXAA 4K10A 4LIXA 3NF2A 4UMJA 5KSXF 3G4FA 3EZ3A 4NFJF 3V1XA 1WKZA 2Q80A 5B0KA 5JV0F 1YYTA 3KRPB 1YYRA 5C05A 1DI1A 4P0XA 2QISA 3LDWA 5B03A 3LZ9A 1VG7A 3SDUA 4RNQA 2Z4XA 4KK2A 3N49F 3LOMA 3LGKA 3LK5A 5E8KA 2AZJA 3Q1OA 3AE0A 1N23A 3LEEA 5DJPF 4JZBA 4KVIA 5ER8A 3IBAA 5JV1F 1HXAA 2E8TA 2Z4ZA 5HN8A 3TFVA 3S9VA 1HX9A 4NFIF 4RXCA 3OABB 1VG4A 4LZ0A 4RXDA 3WCHA 1PS1A 5IL3A 4QXSF 3WCCA 3WEJA 1WL0A 3N6KF 1N24A 2F8CF 4PVXF 2F8ZF 3KRAA 3AQ0A 2AELA 4XQRF 5ERNA 4LFGA 2E8UA 4EA0A 5DGSF 1YYUA 4DZWA 3IPIA 1UBYA 4MC0A 2OPMA 3LVSA 4KQUA 2ONGA 2Z4WA 3Q2QA 5IMNA 2F7MF 5IK0A 4OKZA 3WEIA 4E1EA 3PYBA 4LFEA 3LMDA 3AQCB 4JZXA 3N5JF 4GA3A 5EAUA 5ERMA 3DYFA 2Z7IA 5B0JA 2FTZA 4H5EF 4DWBA 4EA2A 3MAVA 3WSBA 5DGMF 3OABA 1VG3A 4F6VA 5HN9A 3P41A 2E95A 4KVDA 4DXJA 5DJVF 5A0KA 2AEKA 1V4EA 3PH7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J1O A;  4NKF A;  3ZCD A;  2O1O A;  5B00 A;  1KIZ A;  1DGP A;  3M01 A;  1V4K A;  2PS4 A;  5ILJ A;  3P8L A;  5AFX A;  4XQS F;  5AYP A;  3QKC A;  3P5R A;  3W7F A;  5ILY A;  3N45 F;  2Q58 A;  2E93 A;  1UBW A;  3PYA A;  1FPS A;  1WY0 A;  4JXN A;  3VJ9 A;  4LUU A;  5EAT A;  3PKO A;  2Z4V A;  2E90 A;  5AHU B;  3ICN A;  3N5H F;  4P0W A;  4LOB A;  4E9Z A;  5ILK A;  4HD1 A;  5HN7 A;  3WCD A;  5B01 A;  5E8L A;  3WCA A;  4MC8 A;  3EFQ A;  3G4D A;  1RTR A;  1RQJ A;  3Q2Z A;  3WJO A;  3RBM A;  2P1C A;  1YV5 A;  3M02 A;  4JVJ F;  2E8V A;  2Z7H A;  3BNY A;  5JA0 F;  4DHD A;  3VJA A;  4F62 A;  3B7L A;  4LZC A;  1VG6 A;  4FP4 A;  1UBX A;  3PDE A;  5IMP A;  2PS7 A;  3SDR A;  4DEM F;  5ILI A;  4F6X A;  5ILZ A;  3M00 A;  1YYS A;  4KVW A;  5IL8 A;  5IK9 A;  2Z50 A;  5JV2 F;  1YHK A;  2OGD A;  3ICZ A;  3LJI A;  5DJR F;  4DI5 A;  5B02 A;  2Z4Y A;  3WCJ A;  4GAX A;  3LG5 A;  3LSN A;  5DGN F;  4LPH F;  3KRP A;  4OMH A;  2F94 F;  2ZCS A;  1WMW A;  5IVG A;  2J1P A;  3Q30 A;  2E91 A;  4WK5 A;  4DWG A;  4XQT F;  4LTV A;  3AQB B;  3ZMB A;  3WCM A;  1KIY A;  1UBV A;  2E8W A;  5AEL A;  4KKM A;  3WJK A;  1V4I A;  3CKE A;  3UCA A;  3V1V A;  5A0I A;  1N20 A;  2ZCR A;  1JFA A;  3ASX A;  3KB9 A;  2Z78 A;  3WCF A;  3N0F A;  3SDQ A;  4EA1 A;  2E8X A;  4KVY A;  3KRC B;  4LA5 A;  3WEH A;  2H8O A;  4GP1 A;  5EAS A;  3BNX A;  2J5C A;  5IMI A;  3WCE A;  3KRO B;  3WEK A;  1EZF A;  3WCG A;  1N21 A;  3SAE A;  1WL3 A;  3QQV A;  4KWD A;  3V66 A;  4KUX A;  3KRF B;  3TC1 A;  5DW7 A;  3M9U A;  4GP2 A;  4KQS A;  1YJ4 A;  4Q23 A;  2ZEV A;  4KPD A;  3SDT A;  3EGT A;  4RXE A;  5CG5 A;  4P0V A;  1YQ7 A;  2F89 F;  3RMG A;  5JUZ F;  2PS5 A;  5DHI A;  3VJD A;  2Z52 A;  3S4J A;  5E8H A;  4N9U A;  3WEF A;  2OA6 A;  3WC9 A;  5B0L A;  3APZ A;  5B0I A;  2Q9Z A;  4LA6 A;  3ACX A;  3WEG A;  5H9D A;  5DIQ F;  3CP6 A;  5DZ2 A;  3KRA B;  1RQI A;  1N22 A;  4OMG A;  3WCI A;  4NUA A;  3CC9 A;  3N3L F;  1YHL A;  5HNA A;  3ICK A;  2Q9Y A;  3KRC A;  3ZL6 A;  3RYE A;  3OAC B;  3VJE A;  1HM4 A;  2PS8 A;  3P8R A;  4JYX A;  4OGU A;  5ILD A;  1HXG A;  2E94 A;  1V4H A;  2DH4 A;  2ZY1 A;  3KRO A;  1VG2 A;  1YHM A;  3N3D A;  5IM1 A;  1ZW5 A;  4KPJ A;  3ACW A;  1HM7 A;  3KRF A;  4ZQ8 A;  5IKA A;  1V4J A;  5I1U A;  1YYQ A;  2AET A;  4L2X F;  3SDV A;  2OPN A;  3N1W F;  3TFN A;  3ID0 A;  3DYG A;  4RYP A;  3TFP A;  2AZL A;  5CG6 A;  4JXY A;  3WE9 A;  4LLS A;  2VF6 A;  1HXC A;  2EWG A;  1JFG A;  1WL2 A;  4LXW A;  5ILH A;  4KFA A;  2FOR A;  1N1B A;  3RYW A;  1N1Z A;  2ONH A;  3KBK A;  3ICM A;  3LGZ B;  4NG6 A;  3N46 F;  2PS6 A;  1WL1 A;  2ZCQ A;  5ERO A;  3N1V F;  5IN8 A;  2F9K F;  4MC3 A;  4LFV F;  4E9U A;  3OAC A;  2F92 F;  3NPK A;  4NKE A;  3MZV A;  2E4O A;  2ZCO A;  3OYR A;  5IKH A;  3NRI A;  3VJ8 A;  2AZK A;  4QPF A;  5A0J A;  4NFK F;  4LZ3 A;  3WJN A;  3NPR A;  5IK6 A;  3ADZ A;  3WSA A;  4H5D F;  4LLT A;  3ZMC A;  3P5P A;  4LPG F;  4LTZ A;  3TS7 A;  3ACY A;  3LLW A;  4FJQ A;  4N1Z F;  4H5C F;  3DYH A;  2E92 A;  4OKM A;  3M0G A;  4KQ5 A;  5B0M A;  3WCL A;  2I19 A;  2RAH A;  4PVY F;  2ZEU A;  3WCB A;  5DHK A;  3N0G A;  3VJC A;  3ZOU A;  3VJB A;  4RXA A;  4K10 A;  4LIX A;  3NF2 A;  4UMJ A;  5KSX F;  3G4F A;  3EZ3 A;  4NFJ F;  3V1X A;  1WKZ A;  2Q80 A;  5B0K A;  5JV0 F;  1YYT A;  3KRP B;  1YYR A;  5C05 A;  1DI1 A;  4P0X A;  2QIS A;  3LDW A;  5B03 A;  3LZ9 A;  1VG7 A;  3SDU A;  4RNQ A;  2Z4X A;  4KK2 A;  3N49 F;  3LOM A;  3LGK A;  3LK5 A;  5E8K A;  2AZJ A;  3Q1O A;  3AE0 A;  1N23 A;  3LEE A;  5DJP F;  4JZB A;  4KVI A;  5ER8 A;  3IBA A;  5JV1 F;  1HXA A;  2E8T A;  2Z4Z A;  5HN8 A;  3TFV A;  3S9V A;  1HX9 A;  4NFI F;  4RXC A;  3OAB B;  1VG4 A;  4LZ0 A;  4RXD A;  3WCH A;  1PS1 A;  5IL3 A;  4QXS F;  3WCC A;  3WEJ A;  1WL0 A;  3N6K F;  1N24 A;  2F8C F;  4PVX F;  2F8Z F;  3KRA A;  3AQ0 A;  2AEL A;  4XQR F;  5ERN A;  4LFG A;  2E8U A;  4EA0 A;  5DGS F;  1YYU A;  4DZW A;  3IPI A;  1UBY A;  4MC0 A;  2OPM A;  3LVS A;  4KQU A;  2ONG A;  2Z4W A;  3Q2Q A;  5IMN A;  2F7M F;  5IK0 A;  4OKZ A;  3WEI A;  4E1E A;  3PYB A;  4LFE A;  3LMD A;  3AQC B;  4JZX A;  3N5J F;  4GA3 A;  5EAU A;  5ERM A;  3DYF A;  2Z7I A;  5B0J A;  2FTZ A;  4H5E F;  4DWB A;  4EA2 A;  3MAV A;  3WSB A;  5DGM F;  3OAB A;  1VG3 A;  4F6V A;  5HN9 A;  3P41 A;  2E95 A;  4KVD A;  4DXJ A;  5DJV F;  5A0K A;  2AEK A;  1V4E A;  3PH7 A; 
#chains in the Genus database with same CATH topology
 2J1O A;  4NKF A;  3ZCD A;  2O1O A;  5B00 A;  1KIZ A;  1DGP A;  3M01 A;  1V4K A;  2PS4 A;  5ILJ A;  3P8L A;  5AFX A;  4XQS F;  5AYP A;  3QKC A;  3P5R A;  3W7F A;  5ILY A;  3N45 F;  2Q58 A;  2E93 A;  1UBW A;  3PYA A;  1FPS A;  1WY0 A;  4JXN A;  3VJ9 A;  4LUU A;  5EAT A;  3PKO A;  2Z4V A;  2E90 A;  5AHU B;  3ICN A;  3N5H F;  4P0W A;  4LOB A;  4E9Z A;  5ILK A;  4HD1 A;  5HN7 A;  3WCD A;  5B01 A;  5E8L A;  3WCA A;  4MC8 A;  3EFQ A;  3G4D A;  1RTR A;  1RQJ A;  3Q2Z A;  3WJO A;  3RBM A;  2P1C A;  1YV5 A;  3M02 A;  4JVJ F;  2E8V A;  2Z7H A;  3BNY A;  5JA0 F;  4DHD A;  3VJA A;  4F62 A;  3B7L A;  4LZC A;  1VG6 A;  4FP4 A;  1UBX A;  3PDE A;  5IMP A;  2PS7 A;  3SDR A;  4DEM F;  5ILI A;  4F6X A;  5ILZ A;  3M00 A;  1YYS A;  4KVW A;  5IL8 A;  5IK9 A;  2Z50 A;  5JV2 F;  1YHK A;  2OGD A;  3ICZ A;  3LJI A;  5DJR F;  4DI5 A;  5B02 A;  2Z4Y A;  3WCJ A;  4GAX A;  3LG5 A;  3LSN A;  5DGN F;  4LPH F;  3KRP A;  4OMH A;  2F94 F;  2ZCS A;  1WMW A;  5IVG A;  2J1P A;  3Q30 A;  2E91 A;  4WK5 A;  4DWG A;  4XQT F;  4LTV A;  3AQB B;  3ZMB A;  3WCM A;  1KIY A;  1UBV A;  2E8W A;  5AEL A;  4KKM A;  3WJK A;  1V4I A;  3CKE A;  3UCA A;  3V1V A;  5A0I A;  1N20 A;  2ZCR A;  1JFA A;  3ASX A;  3KB9 A;  2Z78 A;  3WCF A;  3N0F A;  3SDQ A;  4EA1 A;  2E8X A;  4KVY A;  3KRC B;  4LA5 A;  3WEH A;  2H8O A;  4GP1 A;  5EAS A;  3BNX A;  2J5C A;  5IMI A;  3WCE A;  3KRO B;  3WEK A;  1EZF A;  3WCG A;  1N21 A;  3SAE A;  1WL3 A;  3QQV A;  4KWD A;  3V66 A;  4KUX A;  3KRF B;  3TC1 A;  5DW7 A;  3M9U A;  4GP2 A;  4KQS A;  1YJ4 A;  4Q23 A;  2ZEV A;  4KPD A;  3SDT A;  3EGT A;  4RXE A;  5CG5 A;  4P0V A;  1YQ7 A;  2F89 F;  3RMG A;  5JUZ F;  2PS5 A;  5DHI A;  3VJD A;  2Z52 A;  3S4J A;  5E8H A;  4N9U A;  3WEF A;  2OA6 A;  3WC9 A;  5B0L A;  3APZ A;  5B0I A;  2Q9Z A;  4LA6 A;  3ACX A;  3WEG A;  5H9D A;  5DIQ F;  3CP6 A;  5DZ2 A;  3KRA B;  1RQI A;  1N22 A;  4OMG A;  3WCI A;  4NUA A;  3CC9 A;  3N3L F;  1YHL A;  5HNA A;  3ICK A;  2Q9Y A;  3KRC A;  3ZL6 A;  3RYE A;  3OAC B;  3VJE A;  1HM4 A;  2PS8 A;  3P8R A;  4JYX A;  4OGU A;  5ILD A;  1HXG A;  2E94 A;  1V4H A;  2DH4 A;  2ZY1 A;  3KRO A;  1VG2 A;  1YHM A;  3N3D A;  5IM1 A;  1ZW5 A;  4KPJ A;  3ACW A;  1HM7 A;  3KRF A;  4ZQ8 A;  5IKA A;  1V4J A;  5I1U A;  1YYQ A;  2AET A;  4L2X F;  3SDV A;  2OPN A;  3N1W F;  3TFN A;  3ID0 A;  3DYG A;  4RYP A;  3TFP A;  2AZL A;  5CG6 A;  4JXY A;  3WE9 A;  4LLS A;  2VF6 A;  1HXC A;  2EWG A;  1JFG A;  1WL2 A;  4LXW A;  5ILH A;  4KFA A;  2FOR A;  1N1B A;  3RYW A;  1N1Z A;  2ONH A;  3KBK A;  3ICM A;  3LGZ B;  4NG6 A;  3N46 F;  2PS6 A;  1WL1 A;  2ZCQ A;  5ERO A;  3N1V F;  5IN8 A;  2F9K F;  4MC3 A;  4LFV F;  4E9U A;  3OAC A;  2F92 F;  3NPK A;  4NKE A;  3MZV A;  2E4O A;  2ZCO A;  3OYR A;  5IKH A;  3NRI A;  3VJ8 A;  2AZK A;  4QPF A;  5A0J A;  4NFK F;  4LZ3 A;  3WJN A;  3NPR A;  5IK6 A;  3ADZ A;  3WSA A;  4H5D F;  4LLT A;  3ZMC A;  3P5P A;  4LPG F;  4LTZ A;  3TS7 A;  3ACY A;  3LLW A;  4FJQ A;  4N1Z F;  4H5C F;  3DYH A;  2E92 A;  4OKM A;  3M0G A;  4KQ5 A;  5B0M A;  3WCL A;  2I19 A;  2RAH A;  4PVY F;  2ZEU A;  3WCB A;  5DHK A;  3N0G A;  3VJC A;  3ZOU A;  3VJB A;  4RXA A;  4K10 A;  4LIX A;  3NF2 A;  4UMJ A;  5KSX F;  3G4F A;  3EZ3 A;  4NFJ F;  3V1X A;  1WKZ A;  2Q80 A;  5B0K A;  5JV0 F;  1YYT A;  3KRP B;  1YYR A;  5C05 A;  1DI1 A;  4P0X A;  2QIS A;  3LDW A;  5B03 A;  3LZ9 A;  1VG7 A;  3SDU A;  4RNQ A;  2Z4X A;  4KK2 A;  3N49 F;  3LOM A;  3LGK A;  3LK5 A;  5E8K A;  2AZJ A;  3Q1O A;  3AE0 A;  1N23 A;  3LEE A;  5DJP F;  4JZB A;  4KVI A;  5ER8 A;  3IBA A;  5JV1 F;  1HXA A;  2E8T A;  2Z4Z A;  5HN8 A;  3TFV A;  3S9V A;  1HX9 A;  4NFI F;  4RXC A;  3OAB B;  1VG4 A;  4LZ0 A;  4RXD A;  3WCH A;  1PS1 A;  5IL3 A;  4QXS F;  3WCC A;  3WEJ A;  1WL0 A;  3N6K F;  1N24 A;  2F8C F;  4PVX F;  2F8Z F;  3KRA A;  3AQ0 A;  2AEL A;  4XQR F;  5ERN A;  4LFG A;  2E8U A;  4EA0 A;  5DGS F;  1YYU A;  4DZW A;  3IPI A;  1UBY A;  4MC0 A;  2OPM A;  3LVS A;  4KQU A;  2ONG A;  2Z4W A;  3Q2Q A;  5IMN A;  2F7M F;  5IK0 A;  4OKZ A;  3WEI A;  4E1E A;  3PYB A;  4LFE A;  3LMD A;  3AQC B;  4JZX A;  3N5J F;  4GA3 A;  5EAU A;  5ERM A;  3DYF A;  2Z7I A;  5B0J A;  2FTZ A;  4H5E F;  4DWB A;  4EA2 A;  3MAV A;  3WSB A;  5DGM F;  3OAB A;  1VG3 A;  4F6V A;  5HN9 A;  3P41 A;  2E95 A;  4KVD A;  4DXJ A;  5DJV F;  5A0K A;  2AEK A;  1V4E A;  3PH7 A; 
#chains in the Genus database with same CATH homology
 2J1O A;  4NKF A;  3ZCD A;  2O1O A;  5B00 A;  1KIZ A;  1DGP A;  3M01 A;  1V4K A;  2PS4 A;  5ILJ A;  3P8L A;  5AFX A;  4XQS F;  5AYP A;  3QKC A;  3P5R A;  3W7F A;  5ILY A;  3N45 F;  2Q58 A;  2E93 A;  1UBW A;  3PYA A;  1FPS A;  1WY0 A;  4JXN A;  3VJ9 A;  4LUU A;  5EAT A;  3PKO A;  2Z4V A;  2E90 A;  5AHU B;  3ICN A;  3N5H F;  4P0W A;  4LOB A;  4E9Z A;  5ILK A;  4HD1 A;  5HN7 A;  3WCD A;  5B01 A;  5E8L A;  3WCA A;  4MC8 A;  3EFQ A;  3G4D A;  1RTR A;  1RQJ A;  3Q2Z A;  3WJO A;  3RBM A;  2P1C A;  1YV5 A;  3M02 A;  4JVJ F;  2E8V A;  2Z7H A;  3BNY A;  5JA0 F;  4DHD A;  3VJA A;  4F62 A;  3B7L A;  4LZC A;  1VG6 A;  4FP4 A;  1UBX A;  3PDE A;  5IMP A;  2PS7 A;  3SDR A;  4DEM F;  5ILI A;  4F6X A;  5ILZ A;  3M00 A;  1YYS A;  4KVW A;  5IL8 A;  5IK9 A;  2Z50 A;  5JV2 F;  1YHK A;  2OGD A;  3ICZ A;  3LJI A;  5DJR F;  4DI5 A;  5B02 A;  2Z4Y A;  3WCJ A;  4GAX A;  3LG5 A;  3LSN A;  5DGN F;  4LPH F;  3KRP A;  4OMH A;  2F94 F;  2ZCS A;  1WMW A;  5IVG A;  2J1P A;  3Q30 A;  2E91 A;  4WK5 A;  4DWG A;  4XQT F;  4LTV A;  3AQB B;  3ZMB A;  3WCM A;  1KIY A;  1UBV A;  2E8W A;  5AEL A;  4KKM A;  3WJK A;  1V4I A;  3CKE A;  3UCA A;  3V1V A;  5A0I A;  1N20 A;  2ZCR A;  1JFA A;  3ASX A;  3KB9 A;  2Z78 A;  3WCF A;  3N0F A;  3SDQ A;  4EA1 A;  2E8X A;  4KVY A;  3KRC B;  4LA5 A;  3WEH A;  2H8O A;  4GP1 A;  5EAS A;  3BNX A;  2J5C A;  5IMI A;  3WCE A;  3KRO B;  3WEK A;  1EZF A;  3WCG A;  1N21 A;  3SAE A;  1WL3 A;  3QQV A;  4KWD A;  3V66 A;  4KUX A;  3KRF B;  3TC1 A;  5DW7 A;  3M9U A;  4GP2 A;  4KQS A;  1YJ4 A;  4Q23 A;  2ZEV A;  4KPD A;  3SDT A;  3EGT A;  4RXE A;  5CG5 A;  4P0V A;  1YQ7 A;  2F89 F;  3RMG A;  5JUZ F;  2PS5 A;  5DHI A;  3VJD A;  2Z52 A;  3S4J A;  5E8H A;  4N9U A;  3WEF A;  2OA6 A;  3WC9 A;  5B0L A;  3APZ A;  5B0I A;  2Q9Z A;  4LA6 A;  3ACX A;  3WEG A;  5H9D A;  5DIQ F;  3CP6 A;  5DZ2 A;  3KRA B;  1RQI A;  1N22 A;  4OMG A;  3WCI A;  4NUA A;  3CC9 A;  3N3L F;  1YHL A;  5HNA A;  3ICK A;  2Q9Y A;  3KRC A;  3ZL6 A;  3RYE A;  3OAC B;  3VJE A;  1HM4 A;  2PS8 A;  3P8R A;  4JYX A;  4OGU A;  5ILD A;  1HXG A;  2E94 A;  1V4H A;  2DH4 A;  2ZY1 A;  3KRO A;  1VG2 A;  1YHM A;  3N3D A;  5IM1 A;  1ZW5 A;  4KPJ A;  3ACW A;  1HM7 A;  3KRF A;  4ZQ8 A;  5IKA A;  1V4J A;  5I1U A;  1YYQ A;  2AET A;  4L2X F;  3SDV A;  2OPN A;  3N1W F;  3TFN A;  3ID0 A;  3DYG A;  4RYP A;  3TFP A;  2AZL A;  5CG6 A;  4JXY A;  3WE9 A;  4LLS A;  2VF6 A;  1HXC A;  2EWG A;  1JFG A;  1WL2 A;  4LXW A;  5ILH A;  4KFA A;  2FOR A;  1N1B A;  3RYW A;  1N1Z A;  2ONH A;  3KBK A;  3ICM A;  3LGZ B;  4NG6 A;  3N46 F;  2PS6 A;  1WL1 A;  2ZCQ A;  5ERO A;  3N1V F;  5IN8 A;  2F9K F;  4MC3 A;  4LFV F;  4E9U A;  3OAC A;  2F92 F;  3NPK A;  4NKE A;  3MZV A;  2E4O A;  2ZCO A;  3OYR A;  5IKH A;  3NRI A;  3VJ8 A;  2AZK A;  4QPF A;  5A0J A;  4NFK F;  4LZ3 A;  3WJN A;  3NPR A;  5IK6 A;  3ADZ A;  3WSA A;  4H5D F;  4LLT A;  3ZMC A;  3P5P A;  4LPG F;  4LTZ A;  3TS7 A;  3ACY A;  3LLW A;  4FJQ A;  4N1Z F;  4H5C F;  3DYH A;  2E92 A;  4OKM A;  3M0G A;  4KQ5 A;  5B0M A;  3WCL A;  2I19 A;  2RAH A;  4PVY F;  2ZEU A;  3WCB A;  5DHK A;  3N0G A;  3VJC A;  3ZOU A;  3VJB A;  4RXA A;  4K10 A;  4LIX A;  3NF2 A;  4UMJ A;  5KSX F;  3G4F A;  3EZ3 A;  4NFJ F;  3V1X A;  1WKZ A;  2Q80 A;  5B0K A;  5JV0 F;  1YYT A;  3KRP B;  1YYR A;  5C05 A;  1DI1 A;  4P0X A;  2QIS A;  3LDW A;  5B03 A;  3LZ9 A;  1VG7 A;  3SDU A;  4RNQ A;  2Z4X A;  4KK2 A;  3N49 F;  3LOM A;  3LGK A;  3LK5 A;  5E8K A;  2AZJ A;  3Q1O A;  3AE0 A;  1N23 A;  3LEE A;  5DJP F;  4JZB A;  4KVI A;  5ER8 A;  3IBA A;  5JV1 F;  1HXA A;  2E8T A;  2Z4Z A;  5HN8 A;  3TFV A;  3S9V A;  1HX9 A;  4NFI F;  4RXC A;  3OAB B;  1VG4 A;  4LZ0 A;  4RXD A;  3WCH A;  1PS1 A;  5IL3 A;  4QXS F;  3WCC A;  3WEJ A;  1WL0 A;  3N6K F;  1N24 A;  2F8C F;  4PVX F;  2F8Z F;  3KRA A;  3AQ0 A;  2AEL A;  4XQR F;  5ERN A;  4LFG A;  2E8U A;  4EA0 A;  5DGS F;  1YYU A;  4DZW A;  3IPI A;  1UBY A;  4MC0 A;  2OPM A;  3LVS A;  4KQU A;  2ONG A;  2Z4W A;  3Q2Q A;  5IMN A;  2F7M F;  5IK0 A;  4OKZ A;  3WEI A;  4E1E A;  3PYB A;  4LFE A;  3LMD A;  3AQC B;  4JZX A;  3N5J F;  4GA3 A;  5EAU A;  5ERM A;  3DYF A;  2Z7I A;  5B0J A;  2FTZ A;  4H5E F;  4DWB A;  4EA2 A;  3MAV A;  3WSB A;  5DGM F;  3OAB A;  1VG3 A;  4F6V A;  5HN9 A;  3P41 A;  2E95 A;  4KVD A;  4DXJ A;  5DJV F;  5A0K A;  2AEK A;  1V4E A;  3PH7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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