3ASXA

Human squalene synthase in complex with 1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}piperidine-3-carboxylic acid
Total Genus 134
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
335
structure length
335
Chain Sequence
LSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Squalene synthase
total genus 134
structure length 335
sequence length 335
ec nomenclature ec 2.5.1.21: Squalene synthase.
pdb deposition date 2010-12-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00494 SQS_PSY Squalene/phytoene synthase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 3asxA00
2E8VA 3LOMA 2PS6A 5AELA 5C05A 4OGUA 2FTZA 3WCBA 3KROA 3ICNA 1V4JA 4H5CF 1N20A 5ILJA 5A0IA 3ACWA 2Z78A 2Q80A 4LXWA 3OYRA 3WC9A 5H9DA 3SDQA 1YJ4A 3NPRA 5DW7A 5IMIA 3UCAA 1EZFA 3LG5A 4MC0A 3S4JA 4LIXA 3Q2ZA 1WMWA 4LFGA 2ZY1A 1UBWA 5B01A 2OPMA 3WCAA 3EGTA 4NUAA 3ASXA 5DJVF 4RXCA 2AETA 4DEMF 2OGDA 3VJAA 3NRIA 5DHIA 1VG7A 3WEHA 5AYPA 1RQJA 2Z7HA 3VJDA 5IVGA 5I1UA 4ZQ8A 5IMPA 4NKFA 3WCDA 1KIYA 3VJ8A 3VJCA 3IBAA 2DH4A 3KRFB 2AZJA 5IL3A 3ZMCA 4L2XF 2F7MF 5E8LA 3QQVA 3WJNA 3KRPB 3N5HF 1UBYA 5ILHA 3DYHA 3SDVA 2Z4XA 3WCHA 2J5CA 5IK6A 4JYXA 2P1CA 5ER8A 5ERNA 2EWGA 3OABB 5A0KA 1VG6A 4K10A 4KVYA 3OACA 3P8RA 5ILKA 2F8ZF 4GP2A 4KQUA 3SDUA 3KROB 4FJQA 3DYGA 1FPSA 4KPJA 1JFGA 4NFKF 4LPGF 5JUZF 4JVJF 1YYSA 3PYBA 3RBMA 3TS7A 3EZ3A 5ERMA 1N1ZA 2PS7A 4MC8A 3ZCDA 3W7FA 2E93A 3N3DA 2AZKA 3WCLA 3KBKA 3V1XA 3AQ0A 5EAUA 1V4EA 4DHDA 2Z50A 1WY0A 2ONGA 2ZCOA 5E8HA 4RNQA 5AFXA 5B0MA 5B03A 2F89F 5IL8A 3AQBB 3WCGA 3RYEA 3WEKA 3ADZA 3P5RA 1HXGA 5DJPF 4LTVA 4P0XA 2FORA 3P41A 3RMGA 1VG4A 4NKEA 2QISA 2H8OA 2J1OA 5DGMF 5ILYA 5JV1F 3LK5A 5IMNA 2E8WA 4NG6A 3N0FA 3WCEA 4XQTF 3Q2QA 3CC9A 4PVYF 1WL0A 2E4OA 3WCMA 4MC3A 4DWGA 3WCIA 2Q9YA 2AEKA 4P0WA 5E8KA 3M9UA 3WCFA 4E9ZA 3IPIA 3DYFA 2VF6A 4RXAA 1DGPA 3ICZA 3QKCA 4KUXA 3SDTA 2F9KF 4EA1A 1HXAA 5HN9A 5DJRF 4DI5A 2E8UA 3PKOA 4LA6A 3MZVA 3OACB 4OMGA 3WSAA 3CP6A 4OMHA 1PS1A 5IN8A 3PH7A 3ZL6A 5KSXF 3KRCB 1WKZA 4H5EF 5DZ2A 4LLTA 3WEJA 4DWBA 3WEIA 1KIZA 3N46F 2E90A 1ZW5A 1UBXA 2E8TA 4QPFA 2Z52A 4XQRF 3AE0A 1YYTA 2Z4YA 3N0GA 5AHUB 2OA6A 3LVSA 4JZXA 3WE9A 4LFVF 5DIQF 3V66A 4RYPA 1WL2A 4GAXA 2O1OA 4LUUA 2ZEVA 3ICMA 5HN7A 4N1ZF 1N23A 3N1WF 4LFEA 3N49F 1V4HA 4N9UA 5EASA 4JXYA 4KVDA 4LZ3A 4LZ0A 3ACYA 3G4FA 2I19A 3S9VA 4DZWA 5IK9A 3M00A 2E94A 4PVXF 5IKAA 5IK0A 3TFVA 1YHLA 5HNAA 5B0IA 2RAHA 1RQIA 3VJEA 4DXJA 4KK2A 2Q9ZA 1VG3A 2F94F 3P5PA 3LJIA 4KVIA 3KRFA 4OKMA 3Q30A 4LA5A 1YQ7A 3MAVA 3SDRA 4KFAA 4UMJA 5CG5A 1V4KA 3N45F 4RXEA 4XQSF 3LEEA 5ILIA 1N1BA 1JFAA 5B0KA 3WSBA 4LZCA 3BNXA 3N3LF 4GA3A 5ILZA 1HM4A 2F8CF 1RTRA 4KVWA 4LTZA 2PS4A 2ZCSA 3V1VA 1N21A 3SAEA 4QXSF 1N24A 1V4IA 3B7LA 3WEFA 5IKHA 3ICKA 4KWDA 4H5DF 3KRAA 5DGNF 2ZCQA 4KKMA 4NFJF 2E95A 2E92A 4LPHF 2ZEUA 1WL1A 2AELA 4HD1A 2ONHA 4LLSA 5EROA 3PDEA 3Q1OA 1YHKA 1YV5A 1UBVA 3ZMBA 3ZOUA 1N22A 3N5JF 4EA2A 4E9UA 3TFNA 3LSNA 5B02A 3ID0A 4NFIF 1DI1A 5JV2F 4WK5A 4EA0A 2Q58A 3N6KF 2Z4VA 4GP1A 3LLWA 1YYUA 3TFPA 2Z7IA 3VJBA 4E1EA 1YYQA 3LGKA 3KB9A 2E91A 3ACXA 3TC1A 3LZ9A 2Z4WA 4LOBA 5JA0F 3AQCB 3P8LA 3WCJA 4F6XA 3WCCA 3CKEA 1WL3A 3NF2A 2PS5A 3WJKA 5B0LA 2Z4ZA 4JXNA 4RXDA 4P0VA 4F6VA 4OKZA 1YHMA 1VG2A 3M01A 3WJOA 4KPDA 5DHKA 3M02A 4JZBA 2E8XA 2OPNA 3M0GA 2J1PA 5DGSF 2PS8A 3KRAB 5JV0F 4FP4A 3EFQA 5B00A 4KQ5A 5B0JA 3LMDA 3APZA 3KRCA 3WEGA 3KRPA 1HXCA 5HN8A 3VJ9A 4KQSA 1HX9A 5CG6A 1HM7A 3PYAA 5EATA 2ZCRA 4F62A 5IM1A 3RYWA 3LDWA 3G4DA 4Q23A 5ILDA 1YYRA 3OABA 3BNYA 2F92F 5A0JA 2AZLA 3LGZB 3N1VF 3NPKA
chains in the Genus database with same CATH superfamily
2E8VA 3LOMA 2PS6A 5AELA 5C05A 4OGUA 2FTZA 3WCBA 3KROA 3ICNA 1V4JA 4H5CF 1N20A 5ILJA 5A0IA 3ACWA 2Z78A 2Q80A 4LXWA 3OYRA 3WC9A 5H9DA 3SDQA 1YJ4A 3NPRA 5DW7A 5IMIA 3UCAA 1EZFA 3LG5A 4MC0A 3S4JA 4LIXA 3Q2ZA 1WMWA 4LFGA 2ZY1A 1UBWA 5B01A 2OPMA 3WCAA 3EGTA 4NUAA 3ASXA 5DJVF 4RXCA 2AETA 4DEMF 2OGDA 3VJAA 3NRIA 5DHIA 1VG7A 3WEHA 5AYPA 1RQJA 2Z7HA 3VJDA 5IVGA 5I1UA 4ZQ8A 5IMPA 4NKFA 3WCDA 1KIYA 3VJ8A 3VJCA 3IBAA 2DH4A 3KRFB 2AZJA 5IL3A 3ZMCA 4L2XF 2F7MF 5E8LA 3QQVA 3WJNA 3KRPB 3N5HF 1UBYA 5ILHA 3DYHA 3SDVA 2Z4XA 3WCHA 2J5CA 5IK6A 4JYXA 2P1CA 5ER8A 5ERNA 2EWGA 3OABB 5A0KA 1VG6A 4K10A 4KVYA 3OACA 3P8RA 5ILKA 2F8ZF 4GP2A 4KQUA 3SDUA 3KROB 4FJQA 3DYGA 1FPSA 4KPJA 1JFGA 4NFKF 4LPGF 5JUZF 4JVJF 1YYSA 3PYBA 3RBMA 3TS7A 3EZ3A 5ERMA 1N1ZA 2PS7A 4MC8A 3ZCDA 3W7FA 2E93A 3N3DA 2AZKA 3WCLA 3KBKA 3V1XA 3AQ0A 5EAUA 1V4EA 4DHDA 2Z50A 1WY0A 2ONGA 2ZCOA 5E8HA 4RNQA 5AFXA 5B0MA 5B03A 2F89F 5IL8A 3AQBB 3WCGA 3RYEA 3WEKA 3ADZA 3P5RA 1HXGA 5DJPF 4LTVA 4P0XA 2FORA 3P41A 3RMGA 1VG4A 4NKEA 2QISA 2H8OA 2J1OA 5DGMF 5ILYA 5JV1F 3LK5A 5IMNA 2E8WA 4NG6A 3N0FA 3WCEA 4XQTF 3Q2QA 3CC9A 4PVYF 1WL0A 2E4OA 3WCMA 4MC3A 4DWGA 3WCIA 2Q9YA 2AEKA 4P0WA 5E8KA 3M9UA 3WCFA 4E9ZA 3IPIA 3DYFA 2VF6A 4RXAA 1DGPA 3ICZA 3QKCA 4KUXA 3SDTA 2F9KF 4EA1A 1HXAA 5HN9A 5DJRF 4DI5A 2E8UA 3PKOA 4LA6A 3MZVA 3OACB 4OMGA 3WSAA 3CP6A 4OMHA 1PS1A 5IN8A 3PH7A 3ZL6A 5KSXF 3KRCB 1WKZA 4H5EF 5DZ2A 4LLTA 3WEJA 4DWBA 3WEIA 1KIZA 3N46F 2E90A 1ZW5A 1UBXA 2E8TA 4QPFA 2Z52A 4XQRF 3AE0A 1YYTA 2Z4YA 3N0GA 5AHUB 2OA6A 3LVSA 4JZXA 3WE9A 4LFVF 5DIQF 3V66A 4RYPA 1WL2A 4GAXA 2O1OA 4LUUA 2ZEVA 3ICMA 5HN7A 4N1ZF 1N23A 3N1WF 4LFEA 3N49F 1V4HA 4N9UA 5EASA 4JXYA 4KVDA 4LZ3A 4LZ0A 3ACYA 3G4FA 2I19A 3S9VA 4DZWA 5IK9A 3M00A 2E94A 4PVXF 5IKAA 5IK0A 3TFVA 1YHLA 5HNAA 5B0IA 2RAHA 1RQIA 3VJEA 4DXJA 4KK2A 2Q9ZA 1VG3A 2F94F 3P5PA 3LJIA 4KVIA 3KRFA 4OKMA 3Q30A 4LA5A 1YQ7A 3MAVA 3SDRA 4KFAA 4UMJA 5CG5A 1V4KA 3N45F 4RXEA 4XQSF 3LEEA 5ILIA 1N1BA 1JFAA 5B0KA 3WSBA 4LZCA 3BNXA 3N3LF 4GA3A 5ILZA 1HM4A 2F8CF 1RTRA 4KVWA 4LTZA 2PS4A 2ZCSA 3V1VA 1N21A 3SAEA 4QXSF 1N24A 1V4IA 3B7LA 3WEFA 5IKHA 3ICKA 4KWDA 4H5DF 3KRAA 5DGNF 2ZCQA 4KKMA 4NFJF 2E95A 2E92A 4LPHF 2ZEUA 1WL1A 2AELA 4HD1A 2ONHA 4LLSA 5EROA 3PDEA 3Q1OA 1YHKA 1YV5A 1UBVA 3ZMBA 3ZOUA 1N22A 3N5JF 4EA2A 4E9UA 3TFNA 3LSNA 5B02A 3ID0A 4NFIF 1DI1A 5JV2F 4WK5A 4EA0A 2Q58A 3N6KF 2Z4VA 4GP1A 3LLWA 1YYUA 3TFPA 2Z7IA 3VJBA 4E1EA 1YYQA 3LGKA 3KB9A 2E91A 3ACXA 3TC1A 3LZ9A 2Z4WA 4LOBA 5JA0F 3AQCB 3P8LA 3WCJA 4F6XA 3WCCA 3CKEA 1WL3A 3NF2A 2PS5A 3WJKA 5B0LA 2Z4ZA 4JXNA 4RXDA 4P0VA 4F6VA 4OKZA 1YHMA 1VG2A 3M01A 3WJOA 4KPDA 5DHKA 3M02A 4JZBA 2E8XA 2OPNA 3M0GA 2J1PA 5DGSF 2PS8A 3KRAB 5JV0F 4FP4A 3EFQA 5B00A 4KQ5A 5B0JA 3LMDA 3APZA 3KRCA 3WEGA 3KRPA 1HXCA 5HN8A 3VJ9A 4KQSA 1HX9A 5CG6A 1HM7A 3PYAA 5EATA 2ZCRA 4F62A 5IM1A 3RYWA 3LDWA 3G4DA 4Q23A 5ILDA 1YYRA 3OABA 3BNYA 2F92F 5A0JA 2AZLA 3LGZB 3N1VF 3NPKA
chains in the Genus database with same CATH topology
2E8VA 3LOMA 2PS6A 5AELA 5C05A 4OGUA 2FTZA 3WCBA 3KROA 3ICNA 1V4JA 4H5CF 1N20A 5ILJA 5A0IA 3ACWA 2Z78A 2Q80A 4LXWA 3OYRA 3WC9A 5H9DA 3SDQA 1YJ4A 3NPRA 5DW7A 5IMIA 3UCAA 1EZFA 3LG5A 4MC0A 3S4JA 4LIXA 3Q2ZA 1WMWA 4LFGA 2ZY1A 1UBWA 5B01A 2OPMA 3WCAA 3EGTA 4NUAA 3ASXA 5DJVF 4RXCA 2AETA 4DEMF 2OGDA 3VJAA 3NRIA 5DHIA 1VG7A 3WEHA 5AYPA 1RQJA 2Z7HA 3VJDA 5IVGA 5I1UA 4ZQ8A 5IMPA 4NKFA 3WCDA 1KIYA 3VJ8A 3VJCA 3IBAA 2DH4A 3KRFB 2AZJA 5IL3A 3ZMCA 4L2XF 2F7MF 5E8LA 3QQVA 3WJNA 3KRPB 3N5HF 1UBYA 5ILHA 3DYHA 3SDVA 2Z4XA 3WCHA 2J5CA 5IK6A 4JYXA 2P1CA 5ER8A 5ERNA 2EWGA 3OABB 5A0KA 1VG6A 4K10A 4KVYA 3OACA 3P8RA 5ILKA 2F8ZF 4GP2A 4KQUA 3SDUA 3KROB 4FJQA 3DYGA 1FPSA 4KPJA 1JFGA 4NFKF 4LPGF 5JUZF 4JVJF 1YYSA 3PYBA 3RBMA 3TS7A 3EZ3A 5ERMA 1N1ZA 2PS7A 4MC8A 3ZCDA 3W7FA 2E93A 3N3DA 2AZKA 3WCLA 3KBKA 3V1XA 3AQ0A 5EAUA 1V4EA 4DHDA 2Z50A 1WY0A 2ONGA 2ZCOA 5E8HA 4RNQA 5AFXA 5B0MA 5B03A 2F89F 5IL8A 3AQBB 3WCGA 3RYEA 3WEKA 3ADZA 3P5RA 1HXGA 5DJPF 4LTVA 4P0XA 2FORA 3P41A 3RMGA 1VG4A 4NKEA 2QISA 2H8OA 2J1OA 5DGMF 5ILYA 5JV1F 3LK5A 5IMNA 2E8WA 4NG6A 3N0FA 3WCEA 4XQTF 3Q2QA 3CC9A 4PVYF 1WL0A 2E4OA 3WCMA 4MC3A 4DWGA 3WCIA 2Q9YA 2AEKA 4P0WA 5E8KA 3M9UA 3WCFA 4E9ZA 3IPIA 3DYFA 2VF6A 4RXAA 1DGPA 3ICZA 3QKCA 4KUXA 3SDTA 2F9KF 4EA1A 1HXAA 5HN9A 5DJRF 4DI5A 2E8UA 3PKOA 4LA6A 3MZVA 3OACB 4OMGA 3WSAA 3CP6A 4OMHA 1PS1A 5IN8A 3PH7A 3ZL6A 5KSXF 3KRCB 1WKZA 4H5EF 5DZ2A 4LLTA 3WEJA 4DWBA 3WEIA 1KIZA 3N46F 2E90A 1ZW5A 1UBXA 2E8TA 4QPFA 2Z52A 4XQRF 3AE0A 1YYTA 2Z4YA 3N0GA 5AHUB 2OA6A 3LVSA 4JZXA 3WE9A 4LFVF 5DIQF 3V66A 4RYPA 1WL2A 4GAXA 2O1OA 4LUUA 2ZEVA 3ICMA 5HN7A 4N1ZF 1N23A 3N1WF 4LFEA 3N49F 1V4HA 4N9UA 5EASA 4JXYA 4KVDA 4LZ3A 4LZ0A 3ACYA 3G4FA 2I19A 3S9VA 4DZWA 5IK9A 3M00A 2E94A 4PVXF 5IKAA 5IK0A 3TFVA 1YHLA 5HNAA 5B0IA 2RAHA 1RQIA 3VJEA 4DXJA 4KK2A 2Q9ZA 1VG3A 2F94F 3P5PA 3LJIA 4KVIA 3KRFA 4OKMA 3Q30A 4LA5A 1YQ7A 3MAVA 3SDRA 4KFAA 4UMJA 5CG5A 1V4KA 3N45F 4RXEA 4XQSF 3LEEA 5ILIA 1N1BA 1JFAA 5B0KA 3WSBA 4LZCA 3BNXA 3N3LF 4GA3A 5ILZA 1HM4A 2F8CF 1RTRA 4KVWA 4LTZA 2PS4A 2ZCSA 3V1VA 1N21A 3SAEA 4QXSF 1N24A 1V4IA 3B7LA 3WEFA 5IKHA 3ICKA 4KWDA 4H5DF 3KRAA 5DGNF 2ZCQA 4KKMA 4NFJF 2E95A 2E92A 4LPHF 2ZEUA 1WL1A 2AELA 4HD1A 2ONHA 4LLSA 5EROA 3PDEA 3Q1OA 1YHKA 1YV5A 1UBVA 3ZMBA 3ZOUA 1N22A 3N5JF 4EA2A 4E9UA 3TFNA 3LSNA 5B02A 3ID0A 4NFIF 1DI1A 5JV2F 4WK5A 4EA0A 2Q58A 3N6KF 2Z4VA 4GP1A 3LLWA 1YYUA 3TFPA 2Z7IA 3VJBA 4E1EA 1YYQA 3LGKA 3KB9A 2E91A 3ACXA 3TC1A 3LZ9A 2Z4WA 4LOBA 5JA0F 3AQCB 3P8LA 3WCJA 4F6XA 3WCCA 3CKEA 1WL3A 3NF2A 2PS5A 3WJKA 5B0LA 2Z4ZA 4JXNA 4RXDA 4P0VA 4F6VA 4OKZA 1YHMA 1VG2A 3M01A 3WJOA 4KPDA 5DHKA 3M02A 4JZBA 2E8XA 2OPNA 3M0GA 2J1PA 5DGSF 2PS8A 3KRAB 5JV0F 4FP4A 3EFQA 5B00A 4KQ5A 5B0JA 3LMDA 3APZA 3KRCA 3WEGA 3KRPA 1HXCA 5HN8A 3VJ9A 4KQSA 1HX9A 5CG6A 1HM7A 3PYAA 5EATA 2ZCRA 4F62A 5IM1A 3RYWA 3LDWA 3G4DA 4Q23A 5ILDA 1YYRA 3OABA 3BNYA 2F92F 5A0JA 2AZLA 3LGZB 3N1VF 3NPKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2E8V A;  3LOM A;  2PS6 A;  5AEL A;  5C05 A;  4OGU A;  2FTZ A;  3WCB A;  3KRO A;  3ICN A;  1V4J A;  4H5C F;  1N20 A;  5ILJ A;  5A0I A;  3ACW A;  2Z78 A;  2Q80 A;  4LXW A;  3OYR A;  3WC9 A;  5H9D A;  3SDQ A;  1YJ4 A;  3NPR A;  5DW7 A;  5IMI A;  3UCA A;  1EZF A;  3LG5 A;  4MC0 A;  3S4J A;  4LIX A;  3Q2Z A;  1WMW A;  4LFG A;  2ZY1 A;  1UBW A;  5B01 A;  2OPM A;  3WCA A;  3EGT A;  4NUA A;  3ASX A;  5DJV F;  4RXC A;  2AET A;  4DEM F;  2OGD A;  3VJA A;  3NRI A;  5DHI A;  1VG7 A;  3WEH A;  5AYP A;  1RQJ A;  2Z7H A;  3VJD A;  5IVG A;  5I1U A;  4ZQ8 A;  5IMP A;  4NKF A;  3WCD A;  1KIY A;  3VJ8 A;  3VJC A;  3IBA A;  2DH4 A;  3KRF B;  2AZJ A;  5IL3 A;  3ZMC A;  4L2X F;  2F7M F;  5E8L A;  3QQV A;  3WJN A;  3KRP B;  3N5H F;  1UBY A;  5ILH A;  3DYH A;  3SDV A;  2Z4X A;  3WCH A;  2J5C A;  5IK6 A;  4JYX A;  2P1C A;  5ER8 A;  5ERN A;  2EWG A;  3OAB B;  5A0K A;  1VG6 A;  4K10 A;  4KVY A;  3OAC A;  3P8R A;  5ILK A;  2F8Z F;  4GP2 A;  4KQU A;  3SDU A;  3KRO B;  4FJQ A;  3DYG A;  1FPS A;  4KPJ A;  1JFG A;  4NFK F;  4LPG F;  5JUZ F;  4JVJ F;  1YYS A;  3PYB A;  3RBM A;  3TS7 A;  3EZ3 A;  5ERM A;  1N1Z A;  2PS7 A;  4MC8 A;  3ZCD A;  3W7F A;  2E93 A;  3N3D A;  2AZK A;  3WCL A;  3KBK A;  3V1X A;  3AQ0 A;  5EAU A;  1V4E A;  4DHD A;  2Z50 A;  1WY0 A;  2ONG A;  2ZCO A;  5E8H A;  4RNQ A;  5AFX A;  5B0M A;  5B03 A;  2F89 F;  5IL8 A;  3AQB B;  3WCG A;  3RYE A;  3WEK A;  3ADZ A;  3P5R A;  1HXG A;  5DJP F;  4LTV A;  4P0X A;  2FOR A;  3P41 A;  3RMG A;  1VG4 A;  4NKE A;  2QIS A;  2H8O A;  2J1O A;  5DGM F;  5ILY A;  5JV1 F;  3LK5 A;  5IMN A;  2E8W A;  4NG6 A;  3N0F A;  3WCE A;  4XQT F;  3Q2Q A;  3CC9 A;  4PVY F;  1WL0 A;  2E4O A;  3WCM A;  4MC3 A;  4DWG A;  3WCI A;  2Q9Y A;  2AEK A;  4P0W A;  5E8K A;  3M9U A;  3WCF A;  4E9Z A;  3IPI A;  3DYF A;  2VF6 A;  4RXA A;  1DGP A;  3ICZ A;  3QKC A;  4KUX A;  3SDT A;  2F9K F;  4EA1 A;  1HXA A;  5HN9 A;  5DJR F;  4DI5 A;  2E8U A;  3PKO A;  4LA6 A;  3MZV A;  3OAC B;  4OMG A;  3WSA A;  3CP6 A;  4OMH A;  1PS1 A;  5IN8 A;  3PH7 A;  3ZL6 A;  5KSX F;  3KRC B;  1WKZ A;  4H5E F;  5DZ2 A;  4LLT A;  3WEJ A;  4DWB A;  3WEI A;  1KIZ A;  3N46 F;  2E90 A;  1ZW5 A;  1UBX A;  2E8T A;  4QPF A;  2Z52 A;  4XQR F;  3AE0 A;  1YYT A;  2Z4Y A;  3N0G A;  5AHU B;  2OA6 A;  3LVS A;  4JZX A;  3WE9 A;  4LFV F;  5DIQ F;  3V66 A;  4RYP A;  1WL2 A;  4GAX A;  2O1O A;  4LUU A;  2ZEV A;  3ICM A;  5HN7 A;  4N1Z F;  1N23 A;  3N1W F;  4LFE A;  3N49 F;  1V4H A;  4N9U A;  5EAS A;  4JXY A;  4KVD A;  4LZ3 A;  4LZ0 A;  3ACY A;  3G4F A;  2I19 A;  3S9V A;  4DZW A;  5IK9 A;  3M00 A;  2E94 A;  4PVX F;  5IKA A;  5IK0 A;  3TFV A;  1YHL A;  5HNA A;  5B0I A;  2RAH A;  1RQI A;  3VJE A;  4DXJ A;  4KK2 A;  2Q9Z A;  1VG3 A;  2F94 F;  3P5P A;  3LJI A;  4KVI A;  3KRF A;  4OKM A;  3Q30 A;  4LA5 A;  1YQ7 A;  3MAV A;  3SDR A;  4KFA A;  4UMJ A;  5CG5 A;  1V4K A;  3N45 F;  4RXE A;  4XQS F;  3LEE A;  5ILI A;  1N1B A;  1JFA A;  5B0K A;  3WSB A;  4LZC A;  3BNX A;  3N3L F;  4GA3 A;  5ILZ A;  1HM4 A;  2F8C F;  1RTR A;  4KVW A;  4LTZ A;  2PS4 A;  2ZCS A;  3V1V A;  1N21 A;  3SAE A;  4QXS F;  1N24 A;  1V4I A;  3B7L A;  3WEF A;  5IKH A;  3ICK A;  4KWD A;  4H5D F;  3KRA A;  5DGN F;  2ZCQ A;  4KKM A;  4NFJ F;  2E95 A;  2E92 A;  4LPH F;  2ZEU A;  1WL1 A;  2AEL A;  4HD1 A;  2ONH A;  4LLS A;  5ERO A;  3PDE A;  3Q1O A;  1YHK A;  1YV5 A;  1UBV A;  3ZMB A;  3ZOU A;  1N22 A;  3N5J F;  4EA2 A;  4E9U A;  3TFN A;  3LSN A;  5B02 A;  3ID0 A;  4NFI F;  1DI1 A;  5JV2 F;  4WK5 A;  4EA0 A;  2Q58 A;  3N6K F;  2Z4V A;  4GP1 A;  3LLW A;  1YYU A;  3TFP A;  2Z7I A;  3VJB A;  4E1E A;  1YYQ A;  3LGK A;  3KB9 A;  2E91 A;  3ACX A;  3TC1 A;  3LZ9 A;  2Z4W A;  4LOB A;  5JA0 F;  3AQC B;  3P8L A;  3WCJ A;  4F6X A;  3WCC A;  3CKE A;  1WL3 A;  3NF2 A;  2PS5 A;  3WJK A;  5B0L A;  2Z4Z A;  4JXN A;  4RXD A;  4P0V A;  4F6V A;  4OKZ A;  1YHM A;  1VG2 A;  3M01 A;  3WJO A;  4KPD A;  5DHK A;  3M02 A;  4JZB A;  2E8X A;  2OPN A;  3M0G A;  2J1P A;  5DGS F;  2PS8 A;  3KRA B;  5JV0 F;  4FP4 A;  3EFQ A;  5B00 A;  4KQ5 A;  5B0J A;  3LMD A;  3APZ A;  3KRC A;  3WEG A;  3KRP A;  1HXC A;  5HN8 A;  3VJ9 A;  4KQS A;  1HX9 A;  5CG6 A;  1HM7 A;  3PYA A;  5EAT A;  2ZCR A;  4F62 A;  5IM1 A;  3RYW A;  3LDW A;  3G4D A;  4Q23 A;  5ILD A;  1YYR A;  3OAB A;  3BNY A;  2F92 F;  5A0J A;  2AZL A;  3LGZ B;  3N1V F;  3NPK A; 
#chains in the Genus database with same CATH topology
 2E8V A;  3LOM A;  2PS6 A;  5AEL A;  5C05 A;  4OGU A;  2FTZ A;  3WCB A;  3KRO A;  3ICN A;  1V4J A;  4H5C F;  1N20 A;  5ILJ A;  5A0I A;  3ACW A;  2Z78 A;  2Q80 A;  4LXW A;  3OYR A;  3WC9 A;  5H9D A;  3SDQ A;  1YJ4 A;  3NPR A;  5DW7 A;  5IMI A;  3UCA A;  1EZF A;  3LG5 A;  4MC0 A;  3S4J A;  4LIX A;  3Q2Z A;  1WMW A;  4LFG A;  2ZY1 A;  1UBW A;  5B01 A;  2OPM A;  3WCA A;  3EGT A;  4NUA A;  3ASX A;  5DJV F;  4RXC A;  2AET A;  4DEM F;  2OGD A;  3VJA A;  3NRI A;  5DHI A;  1VG7 A;  3WEH A;  5AYP A;  1RQJ A;  2Z7H A;  3VJD A;  5IVG A;  5I1U A;  4ZQ8 A;  5IMP A;  4NKF A;  3WCD A;  1KIY A;  3VJ8 A;  3VJC A;  3IBA A;  2DH4 A;  3KRF B;  2AZJ A;  5IL3 A;  3ZMC A;  4L2X F;  2F7M F;  5E8L A;  3QQV A;  3WJN A;  3KRP B;  3N5H F;  1UBY A;  5ILH A;  3DYH A;  3SDV A;  2Z4X A;  3WCH A;  2J5C A;  5IK6 A;  4JYX A;  2P1C A;  5ER8 A;  5ERN A;  2EWG A;  3OAB B;  5A0K A;  1VG6 A;  4K10 A;  4KVY A;  3OAC A;  3P8R A;  5ILK A;  2F8Z F;  4GP2 A;  4KQU A;  3SDU A;  3KRO B;  4FJQ A;  3DYG A;  1FPS A;  4KPJ A;  1JFG A;  4NFK F;  4LPG F;  5JUZ F;  4JVJ F;  1YYS A;  3PYB A;  3RBM A;  3TS7 A;  3EZ3 A;  5ERM A;  1N1Z A;  2PS7 A;  4MC8 A;  3ZCD A;  3W7F A;  2E93 A;  3N3D A;  2AZK A;  3WCL A;  3KBK A;  3V1X A;  3AQ0 A;  5EAU A;  1V4E A;  4DHD A;  2Z50 A;  1WY0 A;  2ONG A;  2ZCO A;  5E8H A;  4RNQ A;  5AFX A;  5B0M A;  5B03 A;  2F89 F;  5IL8 A;  3AQB B;  3WCG A;  3RYE A;  3WEK A;  3ADZ A;  3P5R A;  1HXG A;  5DJP F;  4LTV A;  4P0X A;  2FOR A;  3P41 A;  3RMG A;  1VG4 A;  4NKE A;  2QIS A;  2H8O A;  2J1O A;  5DGM F;  5ILY A;  5JV1 F;  3LK5 A;  5IMN A;  2E8W A;  4NG6 A;  3N0F A;  3WCE A;  4XQT F;  3Q2Q A;  3CC9 A;  4PVY F;  1WL0 A;  2E4O A;  3WCM A;  4MC3 A;  4DWG A;  3WCI A;  2Q9Y A;  2AEK A;  4P0W A;  5E8K A;  3M9U A;  3WCF A;  4E9Z A;  3IPI A;  3DYF A;  2VF6 A;  4RXA A;  1DGP A;  3ICZ A;  3QKC A;  4KUX A;  3SDT A;  2F9K F;  4EA1 A;  1HXA A;  5HN9 A;  5DJR F;  4DI5 A;  2E8U A;  3PKO A;  4LA6 A;  3MZV A;  3OAC B;  4OMG A;  3WSA A;  3CP6 A;  4OMH A;  1PS1 A;  5IN8 A;  3PH7 A;  3ZL6 A;  5KSX F;  3KRC B;  1WKZ A;  4H5E F;  5DZ2 A;  4LLT A;  3WEJ A;  4DWB A;  3WEI A;  1KIZ A;  3N46 F;  2E90 A;  1ZW5 A;  1UBX A;  2E8T A;  4QPF A;  2Z52 A;  4XQR F;  3AE0 A;  1YYT A;  2Z4Y A;  3N0G A;  5AHU B;  2OA6 A;  3LVS A;  4JZX A;  3WE9 A;  4LFV F;  5DIQ F;  3V66 A;  4RYP A;  1WL2 A;  4GAX A;  2O1O A;  4LUU A;  2ZEV A;  3ICM A;  5HN7 A;  4N1Z F;  1N23 A;  3N1W F;  4LFE A;  3N49 F;  1V4H A;  4N9U A;  5EAS A;  4JXY A;  4KVD A;  4LZ3 A;  4LZ0 A;  3ACY A;  3G4F A;  2I19 A;  3S9V A;  4DZW A;  5IK9 A;  3M00 A;  2E94 A;  4PVX F;  5IKA A;  5IK0 A;  3TFV A;  1YHL A;  5HNA A;  5B0I A;  2RAH A;  1RQI A;  3VJE A;  4DXJ A;  4KK2 A;  2Q9Z A;  1VG3 A;  2F94 F;  3P5P A;  3LJI A;  4KVI A;  3KRF A;  4OKM A;  3Q30 A;  4LA5 A;  1YQ7 A;  3MAV A;  3SDR A;  4KFA A;  4UMJ A;  5CG5 A;  1V4K A;  3N45 F;  4RXE A;  4XQS F;  3LEE A;  5ILI A;  1N1B A;  1JFA A;  5B0K A;  3WSB A;  4LZC A;  3BNX A;  3N3L F;  4GA3 A;  5ILZ A;  1HM4 A;  2F8C F;  1RTR A;  4KVW A;  4LTZ A;  2PS4 A;  2ZCS A;  3V1V A;  1N21 A;  3SAE A;  4QXS F;  1N24 A;  1V4I A;  3B7L A;  3WEF A;  5IKH A;  3ICK A;  4KWD A;  4H5D F;  3KRA A;  5DGN F;  2ZCQ A;  4KKM A;  4NFJ F;  2E95 A;  2E92 A;  4LPH F;  2ZEU A;  1WL1 A;  2AEL A;  4HD1 A;  2ONH A;  4LLS A;  5ERO A;  3PDE A;  3Q1O A;  1YHK A;  1YV5 A;  1UBV A;  3ZMB A;  3ZOU A;  1N22 A;  3N5J F;  4EA2 A;  4E9U A;  3TFN A;  3LSN A;  5B02 A;  3ID0 A;  4NFI F;  1DI1 A;  5JV2 F;  4WK5 A;  4EA0 A;  2Q58 A;  3N6K F;  2Z4V A;  4GP1 A;  3LLW A;  1YYU A;  3TFP A;  2Z7I A;  3VJB A;  4E1E A;  1YYQ A;  3LGK A;  3KB9 A;  2E91 A;  3ACX A;  3TC1 A;  3LZ9 A;  2Z4W A;  4LOB A;  5JA0 F;  3AQC B;  3P8L A;  3WCJ A;  4F6X A;  3WCC A;  3CKE A;  1WL3 A;  3NF2 A;  2PS5 A;  3WJK A;  5B0L A;  2Z4Z A;  4JXN A;  4RXD A;  4P0V A;  4F6V A;  4OKZ A;  1YHM A;  1VG2 A;  3M01 A;  3WJO A;  4KPD A;  5DHK A;  3M02 A;  4JZB A;  2E8X A;  2OPN A;  3M0G A;  2J1P A;  5DGS F;  2PS8 A;  3KRA B;  5JV0 F;  4FP4 A;  3EFQ A;  5B00 A;  4KQ5 A;  5B0J A;  3LMD A;  3APZ A;  3KRC A;  3WEG A;  3KRP A;  1HXC A;  5HN8 A;  3VJ9 A;  4KQS A;  1HX9 A;  5CG6 A;  1HM7 A;  3PYA A;  5EAT A;  2ZCR A;  4F62 A;  5IM1 A;  3RYW A;  3LDW A;  3G4D A;  4Q23 A;  5ILD A;  1YYR A;  3OAB A;  3BNY A;  2F92 F;  5A0J A;  2AZL A;  3LGZ B;  3N1V F;  3NPK A; 
#chains in the Genus database with same CATH homology
 2E8V A;  3LOM A;  2PS6 A;  5AEL A;  5C05 A;  4OGU A;  2FTZ A;  3WCB A;  3KRO A;  3ICN A;  1V4J A;  4H5C F;  1N20 A;  5ILJ A;  5A0I A;  3ACW A;  2Z78 A;  2Q80 A;  4LXW A;  3OYR A;  3WC9 A;  5H9D A;  3SDQ A;  1YJ4 A;  3NPR A;  5DW7 A;  5IMI A;  3UCA A;  1EZF A;  3LG5 A;  4MC0 A;  3S4J A;  4LIX A;  3Q2Z A;  1WMW A;  4LFG A;  2ZY1 A;  1UBW A;  5B01 A;  2OPM A;  3WCA A;  3EGT A;  4NUA A;  3ASX A;  5DJV F;  4RXC A;  2AET A;  4DEM F;  2OGD A;  3VJA A;  3NRI A;  5DHI A;  1VG7 A;  3WEH A;  5AYP A;  1RQJ A;  2Z7H A;  3VJD A;  5IVG A;  5I1U A;  4ZQ8 A;  5IMP A;  4NKF A;  3WCD A;  1KIY A;  3VJ8 A;  3VJC A;  3IBA A;  2DH4 A;  3KRF B;  2AZJ A;  5IL3 A;  3ZMC A;  4L2X F;  2F7M F;  5E8L A;  3QQV A;  3WJN A;  3KRP B;  3N5H F;  1UBY A;  5ILH A;  3DYH A;  3SDV A;  2Z4X A;  3WCH A;  2J5C A;  5IK6 A;  4JYX A;  2P1C A;  5ER8 A;  5ERN A;  2EWG A;  3OAB B;  5A0K A;  1VG6 A;  4K10 A;  4KVY A;  3OAC A;  3P8R A;  5ILK A;  2F8Z F;  4GP2 A;  4KQU A;  3SDU A;  3KRO B;  4FJQ A;  3DYG A;  1FPS A;  4KPJ A;  1JFG A;  4NFK F;  4LPG F;  5JUZ F;  4JVJ F;  1YYS A;  3PYB A;  3RBM A;  3TS7 A;  3EZ3 A;  5ERM A;  1N1Z A;  2PS7 A;  4MC8 A;  3ZCD A;  3W7F A;  2E93 A;  3N3D A;  2AZK A;  3WCL A;  3KBK A;  3V1X A;  3AQ0 A;  5EAU A;  1V4E A;  4DHD A;  2Z50 A;  1WY0 A;  2ONG A;  2ZCO A;  5E8H A;  4RNQ A;  5AFX A;  5B0M A;  5B03 A;  2F89 F;  5IL8 A;  3AQB B;  3WCG A;  3RYE A;  3WEK A;  3ADZ A;  3P5R A;  1HXG A;  5DJP F;  4LTV A;  4P0X A;  2FOR A;  3P41 A;  3RMG A;  1VG4 A;  4NKE A;  2QIS A;  2H8O A;  2J1O A;  5DGM F;  5ILY A;  5JV1 F;  3LK5 A;  5IMN A;  2E8W A;  4NG6 A;  3N0F A;  3WCE A;  4XQT F;  3Q2Q A;  3CC9 A;  4PVY F;  1WL0 A;  2E4O A;  3WCM A;  4MC3 A;  4DWG A;  3WCI A;  2Q9Y A;  2AEK A;  4P0W A;  5E8K A;  3M9U A;  3WCF A;  4E9Z A;  3IPI A;  3DYF A;  2VF6 A;  4RXA A;  1DGP A;  3ICZ A;  3QKC A;  4KUX A;  3SDT A;  2F9K F;  4EA1 A;  1HXA A;  5HN9 A;  5DJR F;  4DI5 A;  2E8U A;  3PKO A;  4LA6 A;  3MZV A;  3OAC B;  4OMG A;  3WSA A;  3CP6 A;  4OMH A;  1PS1 A;  5IN8 A;  3PH7 A;  3ZL6 A;  5KSX F;  3KRC B;  1WKZ A;  4H5E F;  5DZ2 A;  4LLT A;  3WEJ A;  4DWB A;  3WEI A;  1KIZ A;  3N46 F;  2E90 A;  1ZW5 A;  1UBX A;  2E8T A;  4QPF A;  2Z52 A;  4XQR F;  3AE0 A;  1YYT A;  2Z4Y A;  3N0G A;  5AHU B;  2OA6 A;  3LVS A;  4JZX A;  3WE9 A;  4LFV F;  5DIQ F;  3V66 A;  4RYP A;  1WL2 A;  4GAX A;  2O1O A;  4LUU A;  2ZEV A;  3ICM A;  5HN7 A;  4N1Z F;  1N23 A;  3N1W F;  4LFE A;  3N49 F;  1V4H A;  4N9U A;  5EAS A;  4JXY A;  4KVD A;  4LZ3 A;  4LZ0 A;  3ACY A;  3G4F A;  2I19 A;  3S9V A;  4DZW A;  5IK9 A;  3M00 A;  2E94 A;  4PVX F;  5IKA A;  5IK0 A;  3TFV A;  1YHL A;  5HNA A;  5B0I A;  2RAH A;  1RQI A;  3VJE A;  4DXJ A;  4KK2 A;  2Q9Z A;  1VG3 A;  2F94 F;  3P5P A;  3LJI A;  4KVI A;  3KRF A;  4OKM A;  3Q30 A;  4LA5 A;  1YQ7 A;  3MAV A;  3SDR A;  4KFA A;  4UMJ A;  5CG5 A;  1V4K A;  3N45 F;  4RXE A;  4XQS F;  3LEE A;  5ILI A;  1N1B A;  1JFA A;  5B0K A;  3WSB A;  4LZC A;  3BNX A;  3N3L F;  4GA3 A;  5ILZ A;  1HM4 A;  2F8C F;  1RTR A;  4KVW A;  4LTZ A;  2PS4 A;  2ZCS A;  3V1V A;  1N21 A;  3SAE A;  4QXS F;  1N24 A;  1V4I A;  3B7L A;  3WEF A;  5IKH A;  3ICK A;  4KWD A;  4H5D F;  3KRA A;  5DGN F;  2ZCQ A;  4KKM A;  4NFJ F;  2E95 A;  2E92 A;  4LPH F;  2ZEU A;  1WL1 A;  2AEL A;  4HD1 A;  2ONH A;  4LLS A;  5ERO A;  3PDE A;  3Q1O A;  1YHK A;  1YV5 A;  1UBV A;  3ZMB A;  3ZOU A;  1N22 A;  3N5J F;  4EA2 A;  4E9U A;  3TFN A;  3LSN A;  5B02 A;  3ID0 A;  4NFI F;  1DI1 A;  5JV2 F;  4WK5 A;  4EA0 A;  2Q58 A;  3N6K F;  2Z4V A;  4GP1 A;  3LLW A;  1YYU A;  3TFP A;  2Z7I A;  3VJB A;  4E1E A;  1YYQ A;  3LGK A;  3KB9 A;  2E91 A;  3ACX A;  3TC1 A;  3LZ9 A;  2Z4W A;  4LOB A;  5JA0 F;  3AQC B;  3P8L A;  3WCJ A;  4F6X A;  3WCC A;  3CKE A;  1WL3 A;  3NF2 A;  2PS5 A;  3WJK A;  5B0L A;  2Z4Z A;  4JXN A;  4RXD A;  4P0V A;  4F6V A;  4OKZ A;  1YHM A;  1VG2 A;  3M01 A;  3WJO A;  4KPD A;  5DHK A;  3M02 A;  4JZB A;  2E8X A;  2OPN A;  3M0G A;  2J1P A;  5DGS F;  2PS8 A;  3KRA B;  5JV0 F;  4FP4 A;  3EFQ A;  5B00 A;  4KQ5 A;  5B0J A;  3LMD A;  3APZ A;  3KRC A;  3WEG A;  3KRP A;  1HXC A;  5HN8 A;  3VJ9 A;  4KQS A;  1HX9 A;  5CG6 A;  1HM7 A;  3PYA A;  5EAT A;  2ZCR A;  4F62 A;  5IM1 A;  3RYW A;  3LDW A;  3G4D A;  4Q23 A;  5ILD A;  1YYR A;  3OAB A;  3BNY A;  2F92 F;  5A0J A;  2AZL A;  3LGZ B;  3N1V F;  3NPK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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