3WSBA

The tuberculosis drug sq109 inhibits trypanosoma cruzi cell proliferation and acts synergistically with posaconazole
Total Genus 138
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
138
sequence length
341
structure length
341
Chain Sequence
DEDLRFCYDILQAVSRSFAVVIMELDEEMRDAVCIFYLVLRALDTVEDDMSIPVEFKLRELPKFHEHLHDTTWCMSGVGVGRERELLERYTHVTRAYSRLGKAYQDVISGICERMANGMCDFLTRKVETKADYDLYCHYVAGLVGHGLTLLYVSSGLEDVRLADDLTNANHMGLFLQKTNIIRDFYEDICEVPPRVFWPREIWEKYTDDLHAFKDELHEAKAVECLNAMVADALVHVPHVVEYLASLRDPSVFAFSAIPQVMAMATLSLVFNNKDVFHTKVKTTRGATARIFHYSTELQATLQMLKTYTLRLAARMNAQDACYDRIEHLVNDAIRAMESHQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
rcsb
molecule tags Transferase/transferase inhibitor
source organism Trypanosoma cruzi
molecule keywords Farnesyltransferase, putative
total genus 138
structure length 341
sequence length 341
chains with identical sequence B, C, D
ec nomenclature ec 2.5.1.21: Squalene synthase.
pdb deposition date 2014-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00494 SQS_PSY Squalene/phytoene synthase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 3wsbA00
1ZW5A 2PS4A 3N45F 2E95A 5IKAA 3KBKA 4LZ0A 1WY0A 1YQ7A 3ACYA 3KRCA 3EZ3A 1YYQA 4P0WA 1WL0A 4LOBA 3ICKA 4RYPA 3ICZA 3N3LF 3TFPA 5DGNF 3N3DA 3ZMBA 1N1BA 4LFEA 3WCEA 5AHUB 5IMIA 3LMDA 3WJOA 3VJCA 3WE9A 4KVYA 3WEGA 4LA5A 4LZCA 2Z4VA 3NRIA 3NF2A 5IL8A 5ILJA 3WJNA 2AETA 5A0IA 3DYHA 4KKMA 5ER8A 3AQBB 3ICMA 2ONGA 4LIXA 3G4FA 3P5PA 1RQIA 5E8LA 1VG3A 4OKMA 5DGSF 4GAXA 4RXCA 4JXNA 1UBXA 1DGPA 5H9DA 3NPRA 5B0JA 2Q80A 4QPFA 5JV2F 1N23A 3SDUA 4JXYA 4XQRF 1VG7A 4PVYF 5EASA 2Q58A 4NFKF 4DWBA 5IK9A 5E8HA 3ICNA 3RBMA 3ZL6A 1V4JA 2E94A 3WCBA 2F92F 2AZKA 4H5DF 3WCMA 3VJ8A 4GA3A 5JV1F 1HX9A 5B0MA 3W7FA 1UBWA 4OKZA 3N1VF 4OGUA 4LZ3A 4RXEA 3LGKA 2Z7IA 3LVSA 2OPMA 4NKFA 3KRAA 3Q2QA 2E90A 3VJ9A 4NUAA 1YYRA 3BNYA 5ERNA 5A0JA 2Z4WA 2Z4XA 1V4KA 1DI1A 1FPSA 1HXCA 3WCHA 5KSXF 5A0KA 3WCIA 3LLWA 3WCGA 4OMGA 5IN8A 5ILDA 2H8OA 1YV5A 2Z4YA 4KQSA 3SDRA 3ASXA 1VG4A 5HN7A 4E9UA 4KK2A 3LSNA 4DEMF 5DJPF 4KWDA 4XQSF 3N5JF 3Q1OA 4DWGA 4LPGF 4LA6A 1YJ4A 3VJEA 1YYSA 5DZ2A 3CP6A 3VJDA 3LEEA 4NFJF 1WL1A 1RTRA 5HNAA 5ILHA 1HM7A 5AYPA 3MAVA 3ACXA 3P8LA 3ID0A 5HN9A 3PH7A 3TC1A 1V4HA 3AE0A 3UCAA 3KROB 5DJVF 4H5EF 2Q9ZA 3OABB 4KVIA 2E8WA 3LG5A 4RNQA 3G4DA 4FJQA 2VF6A 3S4JA 3B7LA 3RYEA 4JZXA 3VJAA 3WEIA 4QXSF 3ACWA 3P8RA 4PVXF 1N20A 3N5HF 2AEKA 4F6XA 3M01A 1WL3A 2F8ZF 3LGZB 5DHKA 2Q9YA 5B0LA 1WKZA 5DJRF 5B02A 2F89F 5ERMA 2E4OA 3CKEA 3N46F 3LK5A 3LDWA 2FORA 4HD1A 3M9UA 3KRFB 5IKHA 1UBVA 4NG6A 3WCLA 4JVJF 2E8UA 5ILZA 5IVGA 5ILIA 3KROA 3Q2ZA 3AQCB 2F94F 3OABA 2OGDA 4RXAA 5IMNA 3V1VA 4DHDA 5CG5A 4KQUA 3ZCDA 4ZQ8A 3P41A 2ZEUA 4DI5A 2ZEVA 2ZCQA 3M02A 2E8VA 2I19A 4K10A 3M0GA 3EFQA 3WSAA 5DW7A 4LPHF 4DZWA 5E8KA 5B00A 5AFXA 3IPIA 2E8TA 2F9KF 5B0KA 3LJIA 1RQJA 3KRCB 3QKCA 3SAEA 4NFIF 4E9ZA 4L2XF 2P1CA 4LLSA 1N1ZA 2Z50A 4LXWA 5EAUA 4KFAA 2AZLA 4LTVA 1N22A 2AZJA 3WEHA 4DXJA 5IK0A 4RXDA 2RAHA 2O1OA 2F8CF 5IL3A 3PKOA 2AELA 1WL2A 1HXAA 2PS6A 3WCDA 1N24A 1PS1A 5B01A 3RYWA 1EZFA 5DGMF 2Z4ZA 3DYGA 2Z52A 1YYUA 4N9UA 3KB9A 1WMWA 2ZCOA 3WSBA 1HM4A 4H5CF 4KPDA 5IM1A 4LTZA 1HXGA 3WEKA 1V4IA 2J1PA 5IK6A 1JFGA 5HN8A 3AQ0A 4E1EA 4KVDA 3PYBA 1YHMA 3OYRA 3SDVA 2E91A 3TS7A 3EGTA 4P0XA 5IMPA 3KRPB 4F6VA 4KUXA 4P0VA 3LOMA 3WCAA 3V66A 4JZBA 2PS7A 2E93A 3VJBA 1VG6A 4FP4A 5ILKA 5C05A 3N49F 2J5CA 3BNXA 2EWGA 4LFGA 3CC9A 3N0FA 3P5RA 3KRAB 4XQTF 3NPKA 1YHKA 2ZCSA 2Z7HA 4KPJA 4UMJA 1V4EA 3N6KF 3OACB 5DIQF 4MC3A 5JA0F 3WC9A 2ZY1A 4KVWA 4OMHA 2ONHA 2Z78A 3PDEA 1UBYA 2QISA 3LZ9A 3SDTA 3ZOUA 5DHIA 3RMGA 4EA2A 4EA0A 4MC8A 4N1ZF 3WCJA 4EA1A 3S9VA 1KIYA 4JYXA 1YYTA 2J1OA 3KRPA 3WEFA 3IBAA 3DYFA 3MZVA 3WJKA 5JV0F 2DH4A 4LLTA 3Q30A 5AELA 5JUZF 2E92A 3PYAA 3WCFA 2ZCRA 2OA6A 5CG6A 3TFVA 4LFVF 2OPNA 1JFAA 5B0IA 3APZA 5ILYA 4LUUA 3KRFA 5EROA 5B03A 4NKEA 2E8XA 3WCCA 2PS5A 3QQVA 3SDQA 1N21A 2F7MF 3OACA 3N1WF 1YHLA 3V1XA 4GP1A 3M00A 3ADZA 4MC0A 1KIZA 3ZMCA 2FTZA 4WK5A 2PS8A 4F62A 4KQ5A 4Q23A 5EATA 4GP2A 3WEJA 1VG2A 3N0GA 3TFNA 5I1UA
chains in the Genus database with same CATH superfamily
1ZW5A 2PS4A 3N45F 2E95A 5IKAA 3KBKA 4LZ0A 1WY0A 1YQ7A 3ACYA 3KRCA 3EZ3A 1YYQA 4P0WA 1WL0A 4LOBA 3ICKA 4RYPA 3ICZA 3N3LF 3TFPA 5DGNF 3N3DA 3ZMBA 1N1BA 4LFEA 3WCEA 5AHUB 5IMIA 3LMDA 3WJOA 3VJCA 3WE9A 4KVYA 3WEGA 4LA5A 4LZCA 2Z4VA 3NRIA 3NF2A 5IL8A 5ILJA 3WJNA 2AETA 5A0IA 3DYHA 4KKMA 5ER8A 3AQBB 3ICMA 2ONGA 4LIXA 3G4FA 3P5PA 1RQIA 5E8LA 1VG3A 4OKMA 5DGSF 4GAXA 4RXCA 4JXNA 1UBXA 1DGPA 5H9DA 3NPRA 5B0JA 2Q80A 4QPFA 5JV2F 1N23A 3SDUA 4JXYA 4XQRF 1VG7A 4PVYF 5EASA 2Q58A 4NFKF 4DWBA 5IK9A 5E8HA 3ICNA 3RBMA 3ZL6A 1V4JA 2E94A 3WCBA 2F92F 2AZKA 4H5DF 3WCMA 3VJ8A 4GA3A 5JV1F 1HX9A 5B0MA 3W7FA 1UBWA 4OKZA 3N1VF 4OGUA 4LZ3A 4RXEA 3LGKA 2Z7IA 3LVSA 2OPMA 4NKFA 3KRAA 3Q2QA 2E90A 3VJ9A 4NUAA 1YYRA 3BNYA 5ERNA 5A0JA 2Z4WA 2Z4XA 1V4KA 1DI1A 1FPSA 1HXCA 3WCHA 5KSXF 5A0KA 3WCIA 3LLWA 3WCGA 4OMGA 5IN8A 5ILDA 2H8OA 1YV5A 2Z4YA 4KQSA 3SDRA 3ASXA 1VG4A 5HN7A 4E9UA 4KK2A 3LSNA 4DEMF 5DJPF 4KWDA 4XQSF 3N5JF 3Q1OA 4DWGA 4LPGF 4LA6A 1YJ4A 3VJEA 1YYSA 5DZ2A 3CP6A 3VJDA 3LEEA 4NFJF 1WL1A 1RTRA 5HNAA 5ILHA 1HM7A 5AYPA 3MAVA 3ACXA 3P8LA 3ID0A 5HN9A 3PH7A 3TC1A 1V4HA 3AE0A 3UCAA 3KROB 5DJVF 4H5EF 2Q9ZA 3OABB 4KVIA 2E8WA 3LG5A 4RNQA 3G4DA 4FJQA 2VF6A 3S4JA 3B7LA 3RYEA 4JZXA 3VJAA 3WEIA 4QXSF 3ACWA 3P8RA 4PVXF 1N20A 3N5HF 2AEKA 4F6XA 3M01A 1WL3A 2F8ZF 3LGZB 5DHKA 2Q9YA 5B0LA 1WKZA 5DJRF 5B02A 2F89F 5ERMA 2E4OA 3CKEA 3N46F 3LK5A 3LDWA 2FORA 4HD1A 3M9UA 3KRFB 5IKHA 1UBVA 4NG6A 3WCLA 4JVJF 2E8UA 5ILZA 5IVGA 5ILIA 3KROA 3Q2ZA 3AQCB 2F94F 3OABA 2OGDA 4RXAA 5IMNA 3V1VA 4DHDA 5CG5A 4KQUA 3ZCDA 4ZQ8A 3P41A 2ZEUA 4DI5A 2ZEVA 2ZCQA 3M02A 2E8VA 2I19A 4K10A 3M0GA 3EFQA 3WSAA 5DW7A 4LPHF 4DZWA 5E8KA 5B00A 5AFXA 3IPIA 2E8TA 2F9KF 5B0KA 3LJIA 1RQJA 3KRCB 3QKCA 3SAEA 4NFIF 4E9ZA 4L2XF 2P1CA 4LLSA 1N1ZA 2Z50A 4LXWA 5EAUA 4KFAA 2AZLA 4LTVA 1N22A 2AZJA 3WEHA 4DXJA 5IK0A 4RXDA 2RAHA 2O1OA 2F8CF 5IL3A 3PKOA 2AELA 1WL2A 1HXAA 2PS6A 3WCDA 1N24A 1PS1A 5B01A 3RYWA 1EZFA 5DGMF 2Z4ZA 3DYGA 2Z52A 1YYUA 4N9UA 3KB9A 1WMWA 2ZCOA 3WSBA 1HM4A 4H5CF 4KPDA 5IM1A 4LTZA 1HXGA 3WEKA 1V4IA 2J1PA 5IK6A 1JFGA 5HN8A 3AQ0A 4E1EA 4KVDA 3PYBA 1YHMA 3OYRA 3SDVA 2E91A 3TS7A 3EGTA 4P0XA 5IMPA 3KRPB 4F6VA 4KUXA 4P0VA 3LOMA 3WCAA 3V66A 4JZBA 2PS7A 2E93A 3VJBA 1VG6A 4FP4A 5ILKA 5C05A 3N49F 2J5CA 3BNXA 2EWGA 4LFGA 3CC9A 3N0FA 3P5RA 3KRAB 4XQTF 3NPKA 1YHKA 2ZCSA 2Z7HA 4KPJA 4UMJA 1V4EA 3N6KF 3OACB 5DIQF 4MC3A 5JA0F 3WC9A 2ZY1A 4KVWA 4OMHA 2ONHA 2Z78A 3PDEA 1UBYA 2QISA 3LZ9A 3SDTA 3ZOUA 5DHIA 3RMGA 4EA2A 4EA0A 4MC8A 4N1ZF 3WCJA 4EA1A 3S9VA 1KIYA 4JYXA 1YYTA 2J1OA 3KRPA 3WEFA 3IBAA 3DYFA 3MZVA 3WJKA 5JV0F 2DH4A 4LLTA 3Q30A 5AELA 5JUZF 2E92A 3PYAA 3WCFA 2ZCRA 2OA6A 5CG6A 3TFVA 4LFVF 2OPNA 1JFAA 5B0IA 3APZA 5ILYA 4LUUA 3KRFA 5EROA 5B03A 4NKEA 2E8XA 3WCCA 2PS5A 3QQVA 3SDQA 1N21A 2F7MF 3OACA 3N1WF 1YHLA 3V1XA 4GP1A 3M00A 3ADZA 4MC0A 1KIZA 3ZMCA 2FTZA 4WK5A 2PS8A 4F62A 4KQ5A 4Q23A 5EATA 4GP2A 3WEJA 1VG2A 3N0GA 3TFNA 5I1UA
chains in the Genus database with same CATH topology
1ZW5A 2PS4A 3N45F 2E95A 5IKAA 3KBKA 4LZ0A 1WY0A 1YQ7A 3ACYA 3KRCA 3EZ3A 1YYQA 4P0WA 1WL0A 4LOBA 3ICKA 4RYPA 3ICZA 3N3LF 3TFPA 5DGNF 3N3DA 3ZMBA 1N1BA 4LFEA 3WCEA 5AHUB 5IMIA 3LMDA 3WJOA 3VJCA 3WE9A 4KVYA 3WEGA 4LA5A 4LZCA 2Z4VA 3NRIA 3NF2A 5IL8A 5ILJA 3WJNA 2AETA 5A0IA 3DYHA 4KKMA 5ER8A 3AQBB 3ICMA 2ONGA 4LIXA 3G4FA 3P5PA 1RQIA 5E8LA 1VG3A 4OKMA 5DGSF 4GAXA 4RXCA 4JXNA 1UBXA 1DGPA 5H9DA 3NPRA 5B0JA 2Q80A 4QPFA 5JV2F 1N23A 3SDUA 4JXYA 4XQRF 1VG7A 4PVYF 5EASA 2Q58A 4NFKF 4DWBA 5IK9A 5E8HA 3ICNA 3RBMA 3ZL6A 1V4JA 2E94A 3WCBA 2F92F 2AZKA 4H5DF 3WCMA 3VJ8A 4GA3A 5JV1F 1HX9A 5B0MA 3W7FA 1UBWA 4OKZA 3N1VF 4OGUA 4LZ3A 4RXEA 3LGKA 2Z7IA 3LVSA 2OPMA 4NKFA 3KRAA 3Q2QA 2E90A 3VJ9A 4NUAA 1YYRA 3BNYA 5ERNA 5A0JA 2Z4WA 2Z4XA 1V4KA 1DI1A 1FPSA 1HXCA 3WCHA 5KSXF 5A0KA 3WCIA 3LLWA 3WCGA 4OMGA 5IN8A 5ILDA 2H8OA 1YV5A 2Z4YA 4KQSA 3SDRA 3ASXA 1VG4A 5HN7A 4E9UA 4KK2A 3LSNA 4DEMF 5DJPF 4KWDA 4XQSF 3N5JF 3Q1OA 4DWGA 4LPGF 4LA6A 1YJ4A 3VJEA 1YYSA 5DZ2A 3CP6A 3VJDA 3LEEA 4NFJF 1WL1A 1RTRA 5HNAA 5ILHA 1HM7A 5AYPA 3MAVA 3ACXA 3P8LA 3ID0A 5HN9A 3PH7A 3TC1A 1V4HA 3AE0A 3UCAA 3KROB 5DJVF 4H5EF 2Q9ZA 3OABB 4KVIA 2E8WA 3LG5A 4RNQA 3G4DA 4FJQA 2VF6A 3S4JA 3B7LA 3RYEA 4JZXA 3VJAA 3WEIA 4QXSF 3ACWA 3P8RA 4PVXF 1N20A 3N5HF 2AEKA 4F6XA 3M01A 1WL3A 2F8ZF 3LGZB 5DHKA 2Q9YA 5B0LA 1WKZA 5DJRF 5B02A 2F89F 5ERMA 2E4OA 3CKEA 3N46F 3LK5A 3LDWA 2FORA 4HD1A 3M9UA 3KRFB 5IKHA 1UBVA 4NG6A 3WCLA 4JVJF 2E8UA 5ILZA 5IVGA 5ILIA 3KROA 3Q2ZA 3AQCB 2F94F 3OABA 2OGDA 4RXAA 5IMNA 3V1VA 4DHDA 5CG5A 4KQUA 3ZCDA 4ZQ8A 3P41A 2ZEUA 4DI5A 2ZEVA 2ZCQA 3M02A 2E8VA 2I19A 4K10A 3M0GA 3EFQA 3WSAA 5DW7A 4LPHF 4DZWA 5E8KA 5B00A 5AFXA 3IPIA 2E8TA 2F9KF 5B0KA 3LJIA 1RQJA 3KRCB 3QKCA 3SAEA 4NFIF 4E9ZA 4L2XF 2P1CA 4LLSA 1N1ZA 2Z50A 4LXWA 5EAUA 4KFAA 2AZLA 4LTVA 1N22A 2AZJA 3WEHA 4DXJA 5IK0A 4RXDA 2RAHA 2O1OA 2F8CF 5IL3A 3PKOA 2AELA 1WL2A 1HXAA 2PS6A 3WCDA 1N24A 1PS1A 5B01A 3RYWA 1EZFA 5DGMF 2Z4ZA 3DYGA 2Z52A 1YYUA 4N9UA 3KB9A 1WMWA 2ZCOA 3WSBA 1HM4A 4H5CF 4KPDA 5IM1A 4LTZA 1HXGA 3WEKA 1V4IA 2J1PA 5IK6A 1JFGA 5HN8A 3AQ0A 4E1EA 4KVDA 3PYBA 1YHMA 3OYRA 3SDVA 2E91A 3TS7A 3EGTA 4P0XA 5IMPA 3KRPB 4F6VA 4KUXA 4P0VA 3LOMA 3WCAA 3V66A 4JZBA 2PS7A 2E93A 3VJBA 1VG6A 4FP4A 5ILKA 5C05A 3N49F 2J5CA 3BNXA 2EWGA 4LFGA 3CC9A 3N0FA 3P5RA 3KRAB 4XQTF 3NPKA 1YHKA 2ZCSA 2Z7HA 4KPJA 4UMJA 1V4EA 3N6KF 3OACB 5DIQF 4MC3A 5JA0F 3WC9A 2ZY1A 4KVWA 4OMHA 2ONHA 2Z78A 3PDEA 1UBYA 2QISA 3LZ9A 3SDTA 3ZOUA 5DHIA 3RMGA 4EA2A 4EA0A 4MC8A 4N1ZF 3WCJA 4EA1A 3S9VA 1KIYA 4JYXA 1YYTA 2J1OA 3KRPA 3WEFA 3IBAA 3DYFA 3MZVA 3WJKA 5JV0F 2DH4A 4LLTA 3Q30A 5AELA 5JUZF 2E92A 3PYAA 3WCFA 2ZCRA 2OA6A 5CG6A 3TFVA 4LFVF 2OPNA 1JFAA 5B0IA 3APZA 5ILYA 4LUUA 3KRFA 5EROA 5B03A 4NKEA 2E8XA 3WCCA 2PS5A 3QQVA 3SDQA 1N21A 2F7MF 3OACA 3N1WF 1YHLA 3V1XA 4GP1A 3M00A 3ADZA 4MC0A 1KIZA 3ZMCA 2FTZA 4WK5A 2PS8A 4F62A 4KQ5A 4Q23A 5EATA 4GP2A 3WEJA 1VG2A 3N0GA 3TFNA 5I1UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZW5 A;  2PS4 A;  3N45 F;  2E95 A;  5IKA A;  3KBK A;  4LZ0 A;  1WY0 A;  1YQ7 A;  3ACY A;  3KRC A;  3EZ3 A;  1YYQ A;  4P0W A;  1WL0 A;  4LOB A;  3ICK A;  4RYP A;  3ICZ A;  3N3L F;  3TFP A;  5DGN F;  3N3D A;  3ZMB A;  1N1B A;  4LFE A;  3WCE A;  5AHU B;  5IMI A;  3LMD A;  3WJO A;  3VJC A;  3WE9 A;  4KVY A;  3WEG A;  4LA5 A;  4LZC A;  2Z4V A;  3NRI A;  3NF2 A;  5IL8 A;  5ILJ A;  3WJN A;  2AET A;  5A0I A;  3DYH A;  4KKM A;  5ER8 A;  3AQB B;  3ICM A;  2ONG A;  4LIX A;  3G4F A;  3P5P A;  1RQI A;  5E8L A;  1VG3 A;  4OKM A;  5DGS F;  4GAX A;  4RXC A;  4JXN A;  1UBX A;  1DGP A;  5H9D A;  3NPR A;  5B0J A;  2Q80 A;  4QPF A;  5JV2 F;  1N23 A;  3SDU A;  4JXY A;  4XQR F;  1VG7 A;  4PVY F;  5EAS A;  2Q58 A;  4NFK F;  4DWB A;  5IK9 A;  5E8H A;  3ICN A;  3RBM A;  3ZL6 A;  1V4J A;  2E94 A;  3WCB A;  2F92 F;  2AZK A;  4H5D F;  3WCM A;  3VJ8 A;  4GA3 A;  5JV1 F;  1HX9 A;  5B0M A;  3W7F A;  1UBW A;  4OKZ A;  3N1V F;  4OGU A;  4LZ3 A;  4RXE A;  3LGK A;  2Z7I A;  3LVS A;  2OPM A;  4NKF A;  3KRA A;  3Q2Q A;  2E90 A;  3VJ9 A;  4NUA A;  1YYR A;  3BNY A;  5ERN A;  5A0J A;  2Z4W A;  2Z4X A;  1V4K A;  1DI1 A;  1FPS A;  1HXC A;  3WCH A;  5KSX F;  5A0K A;  3WCI A;  3LLW A;  3WCG A;  4OMG A;  5IN8 A;  5ILD A;  2H8O A;  1YV5 A;  2Z4Y A;  4KQS A;  3SDR A;  3ASX A;  1VG4 A;  5HN7 A;  4E9U A;  4KK2 A;  3LSN A;  4DEM F;  5DJP F;  4KWD A;  4XQS F;  3N5J F;  3Q1O A;  4DWG A;  4LPG F;  4LA6 A;  1YJ4 A;  3VJE A;  1YYS A;  5DZ2 A;  3CP6 A;  3VJD A;  3LEE A;  4NFJ F;  1WL1 A;  1RTR A;  5HNA A;  5ILH A;  1HM7 A;  5AYP A;  3MAV A;  3ACX A;  3P8L A;  3ID0 A;  5HN9 A;  3PH7 A;  3TC1 A;  1V4H A;  3AE0 A;  3UCA A;  3KRO B;  5DJV F;  4H5E F;  2Q9Z A;  3OAB B;  4KVI A;  2E8W A;  3LG5 A;  4RNQ A;  3G4D A;  4FJQ A;  2VF6 A;  3S4J A;  3B7L A;  3RYE A;  4JZX A;  3VJA A;  3WEI A;  4QXS F;  3ACW A;  3P8R A;  4PVX F;  1N20 A;  3N5H F;  2AEK A;  4F6X A;  3M01 A;  1WL3 A;  2F8Z F;  3LGZ B;  5DHK A;  2Q9Y A;  5B0L A;  1WKZ A;  5DJR F;  5B02 A;  2F89 F;  5ERM A;  2E4O A;  3CKE A;  3N46 F;  3LK5 A;  3LDW A;  2FOR A;  4HD1 A;  3M9U A;  3KRF B;  5IKH A;  1UBV A;  4NG6 A;  3WCL A;  4JVJ F;  2E8U A;  5ILZ A;  5IVG A;  5ILI A;  3KRO A;  3Q2Z A;  3AQC B;  2F94 F;  3OAB A;  2OGD A;  4RXA A;  5IMN A;  3V1V A;  4DHD A;  5CG5 A;  4KQU A;  3ZCD A;  4ZQ8 A;  3P41 A;  2ZEU A;  4DI5 A;  2ZEV A;  2ZCQ A;  3M02 A;  2E8V A;  2I19 A;  4K10 A;  3M0G A;  3EFQ A;  3WSA A;  5DW7 A;  4LPH F;  4DZW A;  5E8K A;  5B00 A;  5AFX A;  3IPI A;  2E8T A;  2F9K F;  5B0K A;  3LJI A;  1RQJ A;  3KRC B;  3QKC A;  3SAE A;  4NFI F;  4E9Z A;  4L2X F;  2P1C A;  4LLS A;  1N1Z A;  2Z50 A;  4LXW A;  5EAU A;  4KFA A;  2AZL A;  4LTV A;  1N22 A;  2AZJ A;  3WEH A;  4DXJ A;  5IK0 A;  4RXD A;  2RAH A;  2O1O A;  2F8C F;  5IL3 A;  3PKO A;  2AEL A;  1WL2 A;  1HXA A;  2PS6 A;  3WCD A;  1N24 A;  1PS1 A;  5B01 A;  3RYW A;  1EZF A;  5DGM F;  2Z4Z A;  3DYG A;  2Z52 A;  1YYU A;  4N9U A;  3KB9 A;  1WMW A;  2ZCO A;  3WSB A;  1HM4 A;  4H5C F;  4KPD A;  5IM1 A;  4LTZ A;  1HXG A;  3WEK A;  1V4I A;  2J1P A;  5IK6 A;  1JFG A;  5HN8 A;  3AQ0 A;  4E1E A;  4KVD A;  3PYB A;  1YHM A;  3OYR A;  3SDV A;  2E91 A;  3TS7 A;  3EGT A;  4P0X A;  5IMP A;  3KRP B;  4F6V A;  4KUX A;  4P0V A;  3LOM A;  3WCA A;  3V66 A;  4JZB A;  2PS7 A;  2E93 A;  3VJB A;  1VG6 A;  4FP4 A;  5ILK A;  5C05 A;  3N49 F;  2J5C A;  3BNX A;  2EWG A;  4LFG A;  3CC9 A;  3N0F A;  3P5R A;  3KRA B;  4XQT F;  3NPK A;  1YHK A;  2ZCS A;  2Z7H A;  4KPJ A;  4UMJ A;  1V4E A;  3N6K F;  3OAC B;  5DIQ F;  4MC3 A;  5JA0 F;  3WC9 A;  2ZY1 A;  4KVW A;  4OMH A;  2ONH A;  2Z78 A;  3PDE A;  1UBY A;  2QIS A;  3LZ9 A;  3SDT A;  3ZOU A;  5DHI A;  3RMG A;  4EA2 A;  4EA0 A;  4MC8 A;  4N1Z F;  3WCJ A;  4EA1 A;  3S9V A;  1KIY A;  4JYX A;  1YYT A;  2J1O A;  3KRP A;  3WEF A;  3IBA A;  3DYF A;  3MZV A;  3WJK A;  5JV0 F;  2DH4 A;  4LLT A;  3Q30 A;  5AEL A;  5JUZ F;  2E92 A;  3PYA A;  3WCF A;  2ZCR A;  2OA6 A;  5CG6 A;  3TFV A;  4LFV F;  2OPN A;  1JFA A;  5B0I A;  3APZ A;  5ILY A;  4LUU A;  3KRF A;  5ERO A;  5B03 A;  4NKE A;  2E8X A;  3WCC A;  2PS5 A;  3QQV A;  3SDQ A;  1N21 A;  2F7M F;  3OAC A;  3N1W F;  1YHL A;  3V1X A;  4GP1 A;  3M00 A;  3ADZ A;  4MC0 A;  1KIZ A;  3ZMC A;  2FTZ A;  4WK5 A;  2PS8 A;  4F62 A;  4KQ5 A;  4Q23 A;  5EAT A;  4GP2 A;  3WEJ A;  1VG2 A;  3N0G A;  3TFN A;  5I1U A; 
#chains in the Genus database with same CATH topology
 1ZW5 A;  2PS4 A;  3N45 F;  2E95 A;  5IKA A;  3KBK A;  4LZ0 A;  1WY0 A;  1YQ7 A;  3ACY A;  3KRC A;  3EZ3 A;  1YYQ A;  4P0W A;  1WL0 A;  4LOB A;  3ICK A;  4RYP A;  3ICZ A;  3N3L F;  3TFP A;  5DGN F;  3N3D A;  3ZMB A;  1N1B A;  4LFE A;  3WCE A;  5AHU B;  5IMI A;  3LMD A;  3WJO A;  3VJC A;  3WE9 A;  4KVY A;  3WEG A;  4LA5 A;  4LZC A;  2Z4V A;  3NRI A;  3NF2 A;  5IL8 A;  5ILJ A;  3WJN A;  2AET A;  5A0I A;  3DYH A;  4KKM A;  5ER8 A;  3AQB B;  3ICM A;  2ONG A;  4LIX A;  3G4F A;  3P5P A;  1RQI A;  5E8L A;  1VG3 A;  4OKM A;  5DGS F;  4GAX A;  4RXC A;  4JXN A;  1UBX A;  1DGP A;  5H9D A;  3NPR A;  5B0J A;  2Q80 A;  4QPF A;  5JV2 F;  1N23 A;  3SDU A;  4JXY A;  4XQR F;  1VG7 A;  4PVY F;  5EAS A;  2Q58 A;  4NFK F;  4DWB A;  5IK9 A;  5E8H A;  3ICN A;  3RBM A;  3ZL6 A;  1V4J A;  2E94 A;  3WCB A;  2F92 F;  2AZK A;  4H5D F;  3WCM A;  3VJ8 A;  4GA3 A;  5JV1 F;  1HX9 A;  5B0M A;  3W7F A;  1UBW A;  4OKZ A;  3N1V F;  4OGU A;  4LZ3 A;  4RXE A;  3LGK A;  2Z7I A;  3LVS A;  2OPM A;  4NKF A;  3KRA A;  3Q2Q A;  2E90 A;  3VJ9 A;  4NUA A;  1YYR A;  3BNY A;  5ERN A;  5A0J A;  2Z4W A;  2Z4X A;  1V4K A;  1DI1 A;  1FPS A;  1HXC A;  3WCH A;  5KSX F;  5A0K A;  3WCI A;  3LLW A;  3WCG A;  4OMG A;  5IN8 A;  5ILD A;  2H8O A;  1YV5 A;  2Z4Y A;  4KQS A;  3SDR A;  3ASX A;  1VG4 A;  5HN7 A;  4E9U A;  4KK2 A;  3LSN A;  4DEM F;  5DJP F;  4KWD A;  4XQS F;  3N5J F;  3Q1O A;  4DWG A;  4LPG F;  4LA6 A;  1YJ4 A;  3VJE A;  1YYS A;  5DZ2 A;  3CP6 A;  3VJD A;  3LEE A;  4NFJ F;  1WL1 A;  1RTR A;  5HNA A;  5ILH A;  1HM7 A;  5AYP A;  3MAV A;  3ACX A;  3P8L A;  3ID0 A;  5HN9 A;  3PH7 A;  3TC1 A;  1V4H A;  3AE0 A;  3UCA A;  3KRO B;  5DJV F;  4H5E F;  2Q9Z A;  3OAB B;  4KVI A;  2E8W A;  3LG5 A;  4RNQ A;  3G4D A;  4FJQ A;  2VF6 A;  3S4J A;  3B7L A;  3RYE A;  4JZX A;  3VJA A;  3WEI A;  4QXS F;  3ACW A;  3P8R A;  4PVX F;  1N20 A;  3N5H F;  2AEK A;  4F6X A;  3M01 A;  1WL3 A;  2F8Z F;  3LGZ B;  5DHK A;  2Q9Y A;  5B0L A;  1WKZ A;  5DJR F;  5B02 A;  2F89 F;  5ERM A;  2E4O A;  3CKE A;  3N46 F;  3LK5 A;  3LDW A;  2FOR A;  4HD1 A;  3M9U A;  3KRF B;  5IKH A;  1UBV A;  4NG6 A;  3WCL A;  4JVJ F;  2E8U A;  5ILZ A;  5IVG A;  5ILI A;  3KRO A;  3Q2Z A;  3AQC B;  2F94 F;  3OAB A;  2OGD A;  4RXA A;  5IMN A;  3V1V A;  4DHD A;  5CG5 A;  4KQU A;  3ZCD A;  4ZQ8 A;  3P41 A;  2ZEU A;  4DI5 A;  2ZEV A;  2ZCQ A;  3M02 A;  2E8V A;  2I19 A;  4K10 A;  3M0G A;  3EFQ A;  3WSA A;  5DW7 A;  4LPH F;  4DZW A;  5E8K A;  5B00 A;  5AFX A;  3IPI A;  2E8T A;  2F9K F;  5B0K A;  3LJI A;  1RQJ A;  3KRC B;  3QKC A;  3SAE A;  4NFI F;  4E9Z A;  4L2X F;  2P1C A;  4LLS A;  1N1Z A;  2Z50 A;  4LXW A;  5EAU A;  4KFA A;  2AZL A;  4LTV A;  1N22 A;  2AZJ A;  3WEH A;  4DXJ A;  5IK0 A;  4RXD A;  2RAH A;  2O1O A;  2F8C F;  5IL3 A;  3PKO A;  2AEL A;  1WL2 A;  1HXA A;  2PS6 A;  3WCD A;  1N24 A;  1PS1 A;  5B01 A;  3RYW A;  1EZF A;  5DGM F;  2Z4Z A;  3DYG A;  2Z52 A;  1YYU A;  4N9U A;  3KB9 A;  1WMW A;  2ZCO A;  3WSB A;  1HM4 A;  4H5C F;  4KPD A;  5IM1 A;  4LTZ A;  1HXG A;  3WEK A;  1V4I A;  2J1P A;  5IK6 A;  1JFG A;  5HN8 A;  3AQ0 A;  4E1E A;  4KVD A;  3PYB A;  1YHM A;  3OYR A;  3SDV A;  2E91 A;  3TS7 A;  3EGT A;  4P0X A;  5IMP A;  3KRP B;  4F6V A;  4KUX A;  4P0V A;  3LOM A;  3WCA A;  3V66 A;  4JZB A;  2PS7 A;  2E93 A;  3VJB A;  1VG6 A;  4FP4 A;  5ILK A;  5C05 A;  3N49 F;  2J5C A;  3BNX A;  2EWG A;  4LFG A;  3CC9 A;  3N0F A;  3P5R A;  3KRA B;  4XQT F;  3NPK A;  1YHK A;  2ZCS A;  2Z7H A;  4KPJ A;  4UMJ A;  1V4E A;  3N6K F;  3OAC B;  5DIQ F;  4MC3 A;  5JA0 F;  3WC9 A;  2ZY1 A;  4KVW A;  4OMH A;  2ONH A;  2Z78 A;  3PDE A;  1UBY A;  2QIS A;  3LZ9 A;  3SDT A;  3ZOU A;  5DHI A;  3RMG A;  4EA2 A;  4EA0 A;  4MC8 A;  4N1Z F;  3WCJ A;  4EA1 A;  3S9V A;  1KIY A;  4JYX A;  1YYT A;  2J1O A;  3KRP A;  3WEF A;  3IBA A;  3DYF A;  3MZV A;  3WJK A;  5JV0 F;  2DH4 A;  4LLT A;  3Q30 A;  5AEL A;  5JUZ F;  2E92 A;  3PYA A;  3WCF A;  2ZCR A;  2OA6 A;  5CG6 A;  3TFV A;  4LFV F;  2OPN A;  1JFA A;  5B0I A;  3APZ A;  5ILY A;  4LUU A;  3KRF A;  5ERO A;  5B03 A;  4NKE A;  2E8X A;  3WCC A;  2PS5 A;  3QQV A;  3SDQ A;  1N21 A;  2F7M F;  3OAC A;  3N1W F;  1YHL A;  3V1X A;  4GP1 A;  3M00 A;  3ADZ A;  4MC0 A;  1KIZ A;  3ZMC A;  2FTZ A;  4WK5 A;  2PS8 A;  4F62 A;  4KQ5 A;  4Q23 A;  5EAT A;  4GP2 A;  3WEJ A;  1VG2 A;  3N0G A;  3TFN A;  5I1U A; 
#chains in the Genus database with same CATH homology
 1ZW5 A;  2PS4 A;  3N45 F;  2E95 A;  5IKA A;  3KBK A;  4LZ0 A;  1WY0 A;  1YQ7 A;  3ACY A;  3KRC A;  3EZ3 A;  1YYQ A;  4P0W A;  1WL0 A;  4LOB A;  3ICK A;  4RYP A;  3ICZ A;  3N3L F;  3TFP A;  5DGN F;  3N3D A;  3ZMB A;  1N1B A;  4LFE A;  3WCE A;  5AHU B;  5IMI A;  3LMD A;  3WJO A;  3VJC A;  3WE9 A;  4KVY A;  3WEG A;  4LA5 A;  4LZC A;  2Z4V A;  3NRI A;  3NF2 A;  5IL8 A;  5ILJ A;  3WJN A;  2AET A;  5A0I A;  3DYH A;  4KKM A;  5ER8 A;  3AQB B;  3ICM A;  2ONG A;  4LIX A;  3G4F A;  3P5P A;  1RQI A;  5E8L A;  1VG3 A;  4OKM A;  5DGS F;  4GAX A;  4RXC A;  4JXN A;  1UBX A;  1DGP A;  5H9D A;  3NPR A;  5B0J A;  2Q80 A;  4QPF A;  5JV2 F;  1N23 A;  3SDU A;  4JXY A;  4XQR F;  1VG7 A;  4PVY F;  5EAS A;  2Q58 A;  4NFK F;  4DWB A;  5IK9 A;  5E8H A;  3ICN A;  3RBM A;  3ZL6 A;  1V4J A;  2E94 A;  3WCB A;  2F92 F;  2AZK A;  4H5D F;  3WCM A;  3VJ8 A;  4GA3 A;  5JV1 F;  1HX9 A;  5B0M A;  3W7F A;  1UBW A;  4OKZ A;  3N1V F;  4OGU A;  4LZ3 A;  4RXE A;  3LGK A;  2Z7I A;  3LVS A;  2OPM A;  4NKF A;  3KRA A;  3Q2Q A;  2E90 A;  3VJ9 A;  4NUA A;  1YYR A;  3BNY A;  5ERN A;  5A0J A;  2Z4W A;  2Z4X A;  1V4K A;  1DI1 A;  1FPS A;  1HXC A;  3WCH A;  5KSX F;  5A0K A;  3WCI A;  3LLW A;  3WCG A;  4OMG A;  5IN8 A;  5ILD A;  2H8O A;  1YV5 A;  2Z4Y A;  4KQS A;  3SDR A;  3ASX A;  1VG4 A;  5HN7 A;  4E9U A;  4KK2 A;  3LSN A;  4DEM F;  5DJP F;  4KWD A;  4XQS F;  3N5J F;  3Q1O A;  4DWG A;  4LPG F;  4LA6 A;  1YJ4 A;  3VJE A;  1YYS A;  5DZ2 A;  3CP6 A;  3VJD A;  3LEE A;  4NFJ F;  1WL1 A;  1RTR A;  5HNA A;  5ILH A;  1HM7 A;  5AYP A;  3MAV A;  3ACX A;  3P8L A;  3ID0 A;  5HN9 A;  3PH7 A;  3TC1 A;  1V4H A;  3AE0 A;  3UCA A;  3KRO B;  5DJV F;  4H5E F;  2Q9Z A;  3OAB B;  4KVI A;  2E8W A;  3LG5 A;  4RNQ A;  3G4D A;  4FJQ A;  2VF6 A;  3S4J A;  3B7L A;  3RYE A;  4JZX A;  3VJA A;  3WEI A;  4QXS F;  3ACW A;  3P8R A;  4PVX F;  1N20 A;  3N5H F;  2AEK A;  4F6X A;  3M01 A;  1WL3 A;  2F8Z F;  3LGZ B;  5DHK A;  2Q9Y A;  5B0L A;  1WKZ A;  5DJR F;  5B02 A;  2F89 F;  5ERM A;  2E4O A;  3CKE A;  3N46 F;  3LK5 A;  3LDW A;  2FOR A;  4HD1 A;  3M9U A;  3KRF B;  5IKH A;  1UBV A;  4NG6 A;  3WCL A;  4JVJ F;  2E8U A;  5ILZ A;  5IVG A;  5ILI A;  3KRO A;  3Q2Z A;  3AQC B;  2F94 F;  3OAB A;  2OGD A;  4RXA A;  5IMN A;  3V1V A;  4DHD A;  5CG5 A;  4KQU A;  3ZCD A;  4ZQ8 A;  3P41 A;  2ZEU A;  4DI5 A;  2ZEV A;  2ZCQ A;  3M02 A;  2E8V A;  2I19 A;  4K10 A;  3M0G A;  3EFQ A;  3WSA A;  5DW7 A;  4LPH F;  4DZW A;  5E8K A;  5B00 A;  5AFX A;  3IPI A;  2E8T A;  2F9K F;  5B0K A;  3LJI A;  1RQJ A;  3KRC B;  3QKC A;  3SAE A;  4NFI F;  4E9Z A;  4L2X F;  2P1C A;  4LLS A;  1N1Z A;  2Z50 A;  4LXW A;  5EAU A;  4KFA A;  2AZL A;  4LTV A;  1N22 A;  2AZJ A;  3WEH A;  4DXJ A;  5IK0 A;  4RXD A;  2RAH A;  2O1O A;  2F8C F;  5IL3 A;  3PKO A;  2AEL A;  1WL2 A;  1HXA A;  2PS6 A;  3WCD A;  1N24 A;  1PS1 A;  5B01 A;  3RYW A;  1EZF A;  5DGM F;  2Z4Z A;  3DYG A;  2Z52 A;  1YYU A;  4N9U A;  3KB9 A;  1WMW A;  2ZCO A;  3WSB A;  1HM4 A;  4H5C F;  4KPD A;  5IM1 A;  4LTZ A;  1HXG A;  3WEK A;  1V4I A;  2J1P A;  5IK6 A;  1JFG A;  5HN8 A;  3AQ0 A;  4E1E A;  4KVD A;  3PYB A;  1YHM A;  3OYR A;  3SDV A;  2E91 A;  3TS7 A;  3EGT A;  4P0X A;  5IMP A;  3KRP B;  4F6V A;  4KUX A;  4P0V A;  3LOM A;  3WCA A;  3V66 A;  4JZB A;  2PS7 A;  2E93 A;  3VJB A;  1VG6 A;  4FP4 A;  5ILK A;  5C05 A;  3N49 F;  2J5C A;  3BNX A;  2EWG A;  4LFG A;  3CC9 A;  3N0F A;  3P5R A;  3KRA B;  4XQT F;  3NPK A;  1YHK A;  2ZCS A;  2Z7H A;  4KPJ A;  4UMJ A;  1V4E A;  3N6K F;  3OAC B;  5DIQ F;  4MC3 A;  5JA0 F;  3WC9 A;  2ZY1 A;  4KVW A;  4OMH A;  2ONH A;  2Z78 A;  3PDE A;  1UBY A;  2QIS A;  3LZ9 A;  3SDT A;  3ZOU A;  5DHI A;  3RMG A;  4EA2 A;  4EA0 A;  4MC8 A;  4N1Z F;  3WCJ A;  4EA1 A;  3S9V A;  1KIY A;  4JYX A;  1YYT A;  2J1O A;  3KRP A;  3WEF A;  3IBA A;  3DYF A;  3MZV A;  3WJK A;  5JV0 F;  2DH4 A;  4LLT A;  3Q30 A;  5AEL A;  5JUZ F;  2E92 A;  3PYA A;  3WCF A;  2ZCR A;  2OA6 A;  5CG6 A;  3TFV A;  4LFV F;  2OPN A;  1JFA A;  5B0I A;  3APZ A;  5ILY A;  4LUU A;  3KRF A;  5ERO A;  5B03 A;  4NKE A;  2E8X A;  3WCC A;  2PS5 A;  3QQV A;  3SDQ A;  1N21 A;  2F7M F;  3OAC A;  3N1W F;  1YHL A;  3V1X A;  4GP1 A;  3M00 A;  3ADZ A;  4MC0 A;  1KIZ A;  3ZMC A;  2FTZ A;  4WK5 A;  2PS8 A;  4F62 A;  4KQ5 A;  4Q23 A;  5EAT A;  4GP2 A;  3WEJ A;  1VG2 A;  3N0G A;  3TFN A;  5I1U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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