4DEMF

Crystal structure of human fpps in complex with ys_04_70
Total Genus 138
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
138
sequence length
346
structure length
346
Chain Sequence
DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells.
pubmed doi rcsb
molecule keywords Farnesyl pyrophosphate synthase
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
total genus 138
structure length 346
sequence length 346
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2012-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4demF00
4N1ZF 3OACB 3ACYA 5JV0F 5IK0A 3IBAA 3TS7A 3WEKA 2E8WA 2F89F 4LZ0A 3V66A 5AYPA 4KK2A 4XQSF 3M01A 4F6VA 3WCEA 4KVYA 2Z4WA 5IKHA 3WEGA 2ZEUA 3N5JF 2E92A 2E93A 5B02A 4QXSF 4XQTF 1VG2A 4RNQA 3OABA 4GP1A 4JXNA 4P0VA 3P41A 5CG5A 2Q80A 4F6XA 4LZ3A 2F9KF 1HXGA 3N1WF 5EASA 4KVDA 2E4OA 1YYSA 1V4IA 1YHLA 3N5HF 5DGNF 2H8OA 4ZQ8A 1HX9A 4NKFA 5JUZF 5IVGA 4KUXA 4E9ZA 3KB9A 4KQ5A 3PDEA 4LIXA 3M00A 4KFAA 5JA0F 3WCBA 5A0JA 3WCHA 4Q23A 4GA3A 4LPHF 3VJAA 3EZ3A 3CC9A 3SDUA 3ZCDA 4PVXF 2P1CA 5DHIA 2PS6A 5DHKA 4MC8A 3VJ8A 4KVIA 2VF6A 4KPJA 1EZFA 4JYXA 1WL0A 3KRAB 1JFAA 1VG4A 4LLTA 4DWBA 4KKMA 1WL1A 2PS4A 2AETA 3LGKA 2F94F 3TFPA 4RXCA 4NUAA 5CG6A 3MAVA 5B0LA 3OABB 1V4JA 4JXYA 4GP2A 1V4KA 4GAXA 2ZCRA 2ONHA 3MZVA 3WCLA 4FP4A 3RYEA 3V1XA 4EA1A 2ZY1A 4DI5A 3WCDA 4HD1A 3DYGA 1KIZA 5IM1A 3N3LF 3ZOUA 3P5RA 5IMIA 1N1BA 2E8TA 4RXDA 3PKOA 5H9DA 4N9UA 2AEKA 4NFKF 3WCCA 2OA6A 5IN8A 3PYAA 1UBVA 3OYRA 3WSAA 4RXAA 2E90A 2OPNA 4LLSA 3KRCA 3ACXA 3AE0A 2RAHA 4NFIF 3LEEA 2O1OA 4EA0A 5ER8A 5E8LA 4H5EF 1HXAA 2OGDA 1WKZA 5AHUB 2DH4A 5HNAA 1YHKA 3N6KF 4KQSA 4DEMF 1UBXA 3SAEA 5C05A 3ICKA 4MC0A 3Q1OA 3EGTA 5ILIA 1VG6A 4F62A 3PYBA 5JV1F 3KRFB 5HN7A 1YYTA 2F7MF 3M02A 4WK5A 2F8CF 2Z4YA 5ILHA 3LJIA 2J1PA 4KVWA 2J1OA 3LK5A 5JV2F 3ZMBA 1N1ZA 5B03A 3BNYA 3LDWA 4OKMA 4NG6A 1HM7A 5DGMF 5HN8A 3SDVA 3NPKA 4LUUA 3ICMA 1DI1A 4JZXA 4L2XF 1WL2A 5A0KA 1YV5A 3LOMA 4LFVF 5ILZA 4KQUA 5B0JA 3KRCB 5EAUA 1N21A 1N24A 3P8LA 4JVJF 3WEIA 4KWDA 1RTRA 5AELA 3LVSA 1N22A 2E95A 1PS1A 5DJVF 3DYFA 2AZLA 4DZWA 2ONGA 3ZL6A 5B00A 1JFGA 4UMJA 3ICNA 4E1EA 1HXCA 2J5CA 3BNXA 3OACA 5I1UA 4FJQA 3LG5A 1YHMA 3LSNA 3N49F 1YYQA 3V1VA 5IKAA 5B0IA 2ZEVA 3N0GA 3RMGA 3NRIA 5ILJA 5B01A 2AZJA 4MC3A 4QPFA 2E8UA 4LPGF 4H5CF 4E9UA 5DJPF 5IL3A 3LLWA 3ACWA 2FTZA 5ERNA 3WJKA 2Z7HA 5E8HA 2E8VA 3TC1A 1VG3A 3ID0A 1YJ4A 4LZCA 2EWGA 3Q2QA 5IK9A 4RYPA 3WCIA 3VJCA 3PH7A 2OPMA 3VJBA 1FPSA 3P8RA 1RQJA 3CP6A 1YQ7A 3WCJA 3N3DA 4LFEA 3S4JA 3ASXA 3WEHA 3ICZA 3W7FA 3G4DA 5IMNA 1UBWA 3P5PA 3M0GA 2E94A 5ILKA 2AELA 3B7LA 3CKEA 2Q9ZA 4OMGA 3KRAA 4LFGA 5DGSF 3UCAA 4LTZA 3WJOA 3AQBB 1YYUA 2ZCQA 3NPRA 4LA5A 4NKEA 5EATA 2Z4VA 3Q30A 4LOBA 1V4EA 3WJNA 2Q58A 3NF2A 4PVYF 3WCAA 3N46F 1VG7A 5DW7A 4P0XA 2Z7IA 3WCGA 4DHDA 3LZ9A 1N20A 2PS5A 3SDRA 3KBKA 5DZ2A 3KROA 1WY0A 3N45F 5B0MA 5ILYA 4KPDA 2Z4ZA 5IMPA 1ZW5A 5EROA 4DWGA 3N0FA 3WSBA 2E8XA 5DJRF 5A0IA 5HN9A 3QKCA 2PS7A 3WE9A 3WEJA 1WL3A 3M9UA 3KRPA 5IK6A 4OKZA 2Z78A 4EA2A 3SDTA 5B0KA 1KIYA 3WEFA 2F92F 3G4FA 3LGZB 3ADZA 2AZKA 3AQ0A 2E91A 2I19A 4XQRF 5E8KA 4RXEA 2PS8A 1YYRA 3APZA 1V4HA 3WCFA 1DGPA 4LA6A 3ZMCA 3VJEA 3IPIA 4LTVA 4OGUA 2Z50A 3SDQA 3TFNA 1UBYA 1N23A 2FORA 1HM4A 3RBMA 3N1VF 3TFVA 5ILDA 3RYWA 3KRFA 5KSXF 4OMHA 3KROB 3WC9A 4DXJA 3EFQA 3S9VA 3QQVA 5AFXA 3WCMA 3DYHA 4JZBA 2Q9YA 1WMWA 3VJ9A 4P0WA 2Z4XA 2F8ZF 2ZCOA 3LMDA 5ERMA 3KRPB 5DIQF 4NFJF 2Z52A 1RQIA 4H5DF 4LXWA 2QISA 2ZCSA 3Q2ZA 3VJDA 3AQCB 4K10A 5IL8A
chains in the Genus database with same CATH superfamily
4N1ZF 3OACB 3ACYA 5JV0F 5IK0A 3IBAA 3TS7A 3WEKA 2E8WA 2F89F 4LZ0A 3V66A 5AYPA 4KK2A 4XQSF 3M01A 4F6VA 3WCEA 4KVYA 2Z4WA 5IKHA 3WEGA 2ZEUA 3N5JF 2E92A 2E93A 5B02A 4QXSF 4XQTF 1VG2A 4RNQA 3OABA 4GP1A 4JXNA 4P0VA 3P41A 5CG5A 2Q80A 4F6XA 4LZ3A 2F9KF 1HXGA 3N1WF 5EASA 4KVDA 2E4OA 1YYSA 1V4IA 1YHLA 3N5HF 5DGNF 2H8OA 4ZQ8A 1HX9A 4NKFA 5JUZF 5IVGA 4KUXA 4E9ZA 3KB9A 4KQ5A 3PDEA 4LIXA 3M00A 4KFAA 5JA0F 3WCBA 5A0JA 3WCHA 4Q23A 4GA3A 4LPHF 3VJAA 3EZ3A 3CC9A 3SDUA 3ZCDA 4PVXF 2P1CA 5DHIA 2PS6A 5DHKA 4MC8A 3VJ8A 4KVIA 2VF6A 4KPJA 1EZFA 4JYXA 1WL0A 3KRAB 1JFAA 1VG4A 4LLTA 4DWBA 4KKMA 1WL1A 2PS4A 2AETA 3LGKA 2F94F 3TFPA 4RXCA 4NUAA 5CG6A 3MAVA 5B0LA 3OABB 1V4JA 4JXYA 4GP2A 1V4KA 4GAXA 2ZCRA 2ONHA 3MZVA 3WCLA 4FP4A 3RYEA 3V1XA 4EA1A 2ZY1A 4DI5A 3WCDA 4HD1A 3DYGA 1KIZA 5IM1A 3N3LF 3ZOUA 3P5RA 5IMIA 1N1BA 2E8TA 4RXDA 3PKOA 5H9DA 4N9UA 2AEKA 4NFKF 3WCCA 2OA6A 5IN8A 3PYAA 1UBVA 3OYRA 3WSAA 4RXAA 2E90A 2OPNA 4LLSA 3KRCA 3ACXA 3AE0A 2RAHA 4NFIF 3LEEA 2O1OA 4EA0A 5ER8A 5E8LA 4H5EF 1HXAA 2OGDA 1WKZA 5AHUB 2DH4A 5HNAA 1YHKA 3N6KF 4KQSA 4DEMF 1UBXA 3SAEA 5C05A 3ICKA 4MC0A 3Q1OA 3EGTA 5ILIA 1VG6A 4F62A 3PYBA 5JV1F 3KRFB 5HN7A 1YYTA 2F7MF 3M02A 4WK5A 2F8CF 2Z4YA 5ILHA 3LJIA 2J1PA 4KVWA 2J1OA 3LK5A 5JV2F 3ZMBA 1N1ZA 5B03A 3BNYA 3LDWA 4OKMA 4NG6A 1HM7A 5DGMF 5HN8A 3SDVA 3NPKA 4LUUA 3ICMA 1DI1A 4JZXA 4L2XF 1WL2A 5A0KA 1YV5A 3LOMA 4LFVF 5ILZA 4KQUA 5B0JA 3KRCB 5EAUA 1N21A 1N24A 3P8LA 4JVJF 3WEIA 4KWDA 1RTRA 5AELA 3LVSA 1N22A 2E95A 1PS1A 5DJVF 3DYFA 2AZLA 4DZWA 2ONGA 3ZL6A 5B00A 1JFGA 4UMJA 3ICNA 4E1EA 1HXCA 2J5CA 3BNXA 3OACA 5I1UA 4FJQA 3LG5A 1YHMA 3LSNA 3N49F 1YYQA 3V1VA 5IKAA 5B0IA 2ZEVA 3N0GA 3RMGA 3NRIA 5ILJA 5B01A 2AZJA 4MC3A 4QPFA 2E8UA 4LPGF 4H5CF 4E9UA 5DJPF 5IL3A 3LLWA 3ACWA 2FTZA 5ERNA 3WJKA 2Z7HA 5E8HA 2E8VA 3TC1A 1VG3A 3ID0A 1YJ4A 4LZCA 2EWGA 3Q2QA 5IK9A 4RYPA 3WCIA 3VJCA 3PH7A 2OPMA 3VJBA 1FPSA 3P8RA 1RQJA 3CP6A 1YQ7A 3WCJA 3N3DA 4LFEA 3S4JA 3ASXA 3WEHA 3ICZA 3W7FA 3G4DA 5IMNA 1UBWA 3P5PA 3M0GA 2E94A 5ILKA 2AELA 3B7LA 3CKEA 2Q9ZA 4OMGA 3KRAA 4LFGA 5DGSF 3UCAA 4LTZA 3WJOA 3AQBB 1YYUA 2ZCQA 3NPRA 4LA5A 4NKEA 5EATA 2Z4VA 3Q30A 4LOBA 1V4EA 3WJNA 2Q58A 3NF2A 4PVYF 3WCAA 3N46F 1VG7A 5DW7A 4P0XA 2Z7IA 3WCGA 4DHDA 3LZ9A 1N20A 2PS5A 3SDRA 3KBKA 5DZ2A 3KROA 1WY0A 3N45F 5B0MA 5ILYA 4KPDA 2Z4ZA 5IMPA 1ZW5A 5EROA 4DWGA 3N0FA 3WSBA 2E8XA 5DJRF 5A0IA 5HN9A 3QKCA 2PS7A 3WE9A 3WEJA 1WL3A 3M9UA 3KRPA 5IK6A 4OKZA 2Z78A 4EA2A 3SDTA 5B0KA 1KIYA 3WEFA 2F92F 3G4FA 3LGZB 3ADZA 2AZKA 3AQ0A 2E91A 2I19A 4XQRF 5E8KA 4RXEA 2PS8A 1YYRA 3APZA 1V4HA 3WCFA 1DGPA 4LA6A 3ZMCA 3VJEA 3IPIA 4LTVA 4OGUA 2Z50A 3SDQA 3TFNA 1UBYA 1N23A 2FORA 1HM4A 3RBMA 3N1VF 3TFVA 5ILDA 3RYWA 3KRFA 5KSXF 4OMHA 3KROB 3WC9A 4DXJA 3EFQA 3S9VA 3QQVA 5AFXA 3WCMA 3DYHA 4JZBA 2Q9YA 1WMWA 3VJ9A 4P0WA 2Z4XA 2F8ZF 2ZCOA 3LMDA 5ERMA 3KRPB 5DIQF 4NFJF 2Z52A 1RQIA 4H5DF 4LXWA 2QISA 2ZCSA 3Q2ZA 3VJDA 3AQCB 4K10A 5IL8A
chains in the Genus database with same CATH topology
4N1ZF 3OACB 3ACYA 5JV0F 5IK0A 3IBAA 3TS7A 3WEKA 2E8WA 2F89F 4LZ0A 3V66A 5AYPA 4KK2A 4XQSF 3M01A 4F6VA 3WCEA 4KVYA 2Z4WA 5IKHA 3WEGA 2ZEUA 3N5JF 2E92A 2E93A 5B02A 4QXSF 4XQTF 1VG2A 4RNQA 3OABA 4GP1A 4JXNA 4P0VA 3P41A 5CG5A 2Q80A 4F6XA 4LZ3A 2F9KF 1HXGA 3N1WF 5EASA 4KVDA 2E4OA 1YYSA 1V4IA 1YHLA 3N5HF 5DGNF 2H8OA 4ZQ8A 1HX9A 4NKFA 5JUZF 5IVGA 4KUXA 4E9ZA 3KB9A 4KQ5A 3PDEA 4LIXA 3M00A 4KFAA 5JA0F 3WCBA 5A0JA 3WCHA 4Q23A 4GA3A 4LPHF 3VJAA 3EZ3A 3CC9A 3SDUA 3ZCDA 4PVXF 2P1CA 5DHIA 2PS6A 5DHKA 4MC8A 3VJ8A 4KVIA 2VF6A 4KPJA 1EZFA 4JYXA 1WL0A 3KRAB 1JFAA 1VG4A 4LLTA 4DWBA 4KKMA 1WL1A 2PS4A 2AETA 3LGKA 2F94F 3TFPA 4RXCA 4NUAA 5CG6A 3MAVA 5B0LA 3OABB 1V4JA 4JXYA 4GP2A 1V4KA 4GAXA 2ZCRA 2ONHA 3MZVA 3WCLA 4FP4A 3RYEA 3V1XA 4EA1A 2ZY1A 4DI5A 3WCDA 4HD1A 3DYGA 1KIZA 5IM1A 3N3LF 3ZOUA 3P5RA 5IMIA 1N1BA 2E8TA 4RXDA 3PKOA 5H9DA 4N9UA 2AEKA 4NFKF 3WCCA 2OA6A 5IN8A 3PYAA 1UBVA 3OYRA 3WSAA 4RXAA 2E90A 2OPNA 4LLSA 3KRCA 3ACXA 3AE0A 2RAHA 4NFIF 3LEEA 2O1OA 4EA0A 5ER8A 5E8LA 4H5EF 1HXAA 2OGDA 1WKZA 5AHUB 2DH4A 5HNAA 1YHKA 3N6KF 4KQSA 4DEMF 1UBXA 3SAEA 5C05A 3ICKA 4MC0A 3Q1OA 3EGTA 5ILIA 1VG6A 4F62A 3PYBA 5JV1F 3KRFB 5HN7A 1YYTA 2F7MF 3M02A 4WK5A 2F8CF 2Z4YA 5ILHA 3LJIA 2J1PA 4KVWA 2J1OA 3LK5A 5JV2F 3ZMBA 1N1ZA 5B03A 3BNYA 3LDWA 4OKMA 4NG6A 1HM7A 5DGMF 5HN8A 3SDVA 3NPKA 4LUUA 3ICMA 1DI1A 4JZXA 4L2XF 1WL2A 5A0KA 1YV5A 3LOMA 4LFVF 5ILZA 4KQUA 5B0JA 3KRCB 5EAUA 1N21A 1N24A 3P8LA 4JVJF 3WEIA 4KWDA 1RTRA 5AELA 3LVSA 1N22A 2E95A 1PS1A 5DJVF 3DYFA 2AZLA 4DZWA 2ONGA 3ZL6A 5B00A 1JFGA 4UMJA 3ICNA 4E1EA 1HXCA 2J5CA 3BNXA 3OACA 5I1UA 4FJQA 3LG5A 1YHMA 3LSNA 3N49F 1YYQA 3V1VA 5IKAA 5B0IA 2ZEVA 3N0GA 3RMGA 3NRIA 5ILJA 5B01A 2AZJA 4MC3A 4QPFA 2E8UA 4LPGF 4H5CF 4E9UA 5DJPF 5IL3A 3LLWA 3ACWA 2FTZA 5ERNA 3WJKA 2Z7HA 5E8HA 2E8VA 3TC1A 1VG3A 3ID0A 1YJ4A 4LZCA 2EWGA 3Q2QA 5IK9A 4RYPA 3WCIA 3VJCA 3PH7A 2OPMA 3VJBA 1FPSA 3P8RA 1RQJA 3CP6A 1YQ7A 3WCJA 3N3DA 4LFEA 3S4JA 3ASXA 3WEHA 3ICZA 3W7FA 3G4DA 5IMNA 1UBWA 3P5PA 3M0GA 2E94A 5ILKA 2AELA 3B7LA 3CKEA 2Q9ZA 4OMGA 3KRAA 4LFGA 5DGSF 3UCAA 4LTZA 3WJOA 3AQBB 1YYUA 2ZCQA 3NPRA 4LA5A 4NKEA 5EATA 2Z4VA 3Q30A 4LOBA 1V4EA 3WJNA 2Q58A 3NF2A 4PVYF 3WCAA 3N46F 1VG7A 5DW7A 4P0XA 2Z7IA 3WCGA 4DHDA 3LZ9A 1N20A 2PS5A 3SDRA 3KBKA 5DZ2A 3KROA 1WY0A 3N45F 5B0MA 5ILYA 4KPDA 2Z4ZA 5IMPA 1ZW5A 5EROA 4DWGA 3N0FA 3WSBA 2E8XA 5DJRF 5A0IA 5HN9A 3QKCA 2PS7A 3WE9A 3WEJA 1WL3A 3M9UA 3KRPA 5IK6A 4OKZA 2Z78A 4EA2A 3SDTA 5B0KA 1KIYA 3WEFA 2F92F 3G4FA 3LGZB 3ADZA 2AZKA 3AQ0A 2E91A 2I19A 4XQRF 5E8KA 4RXEA 2PS8A 1YYRA 3APZA 1V4HA 3WCFA 1DGPA 4LA6A 3ZMCA 3VJEA 3IPIA 4LTVA 4OGUA 2Z50A 3SDQA 3TFNA 1UBYA 1N23A 2FORA 1HM4A 3RBMA 3N1VF 3TFVA 5ILDA 3RYWA 3KRFA 5KSXF 4OMHA 3KROB 3WC9A 4DXJA 3EFQA 3S9VA 3QQVA 5AFXA 3WCMA 3DYHA 4JZBA 2Q9YA 1WMWA 3VJ9A 4P0WA 2Z4XA 2F8ZF 2ZCOA 3LMDA 5ERMA 3KRPB 5DIQF 4NFJF 2Z52A 1RQIA 4H5DF 4LXWA 2QISA 2ZCSA 3Q2ZA 3VJDA 3AQCB 4K10A 5IL8A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4N1Z F;  3OAC B;  3ACY A;  5JV0 F;  5IK0 A;  3IBA A;  3TS7 A;  3WEK A;  2E8W A;  2F89 F;  4LZ0 A;  3V66 A;  5AYP A;  4KK2 A;  4XQS F;  3M01 A;  4F6V A;  3WCE A;  4KVY A;  2Z4W A;  5IKH A;  3WEG A;  2ZEU A;  3N5J F;  2E92 A;  2E93 A;  5B02 A;  4QXS F;  4XQT F;  1VG2 A;  4RNQ A;  3OAB A;  4GP1 A;  4JXN A;  4P0V A;  3P41 A;  5CG5 A;  2Q80 A;  4F6X A;  4LZ3 A;  2F9K F;  1HXG A;  3N1W F;  5EAS A;  4KVD A;  2E4O A;  1YYS A;  1V4I A;  1YHL A;  3N5H F;  5DGN F;  2H8O A;  4ZQ8 A;  1HX9 A;  4NKF A;  5JUZ F;  5IVG A;  4KUX A;  4E9Z A;  3KB9 A;  4KQ5 A;  3PDE A;  4LIX A;  3M00 A;  4KFA A;  5JA0 F;  3WCB A;  5A0J A;  3WCH A;  4Q23 A;  4GA3 A;  4LPH F;  3VJA A;  3EZ3 A;  3CC9 A;  3SDU A;  3ZCD A;  4PVX F;  2P1C A;  5DHI A;  2PS6 A;  5DHK A;  4MC8 A;  3VJ8 A;  4KVI A;  2VF6 A;  4KPJ A;  1EZF A;  4JYX A;  1WL0 A;  3KRA B;  1JFA A;  1VG4 A;  4LLT A;  4DWB A;  4KKM A;  1WL1 A;  2PS4 A;  2AET A;  3LGK A;  2F94 F;  3TFP A;  4RXC A;  4NUA A;  5CG6 A;  3MAV A;  5B0L A;  3OAB B;  1V4J A;  4JXY A;  4GP2 A;  1V4K A;  4GAX A;  2ZCR A;  2ONH A;  3MZV A;  3WCL A;  4FP4 A;  3RYE A;  3V1X A;  4EA1 A;  2ZY1 A;  4DI5 A;  3WCD A;  4HD1 A;  3DYG A;  1KIZ A;  5IM1 A;  3N3L F;  3ZOU A;  3P5R A;  5IMI A;  1N1B A;  2E8T A;  4RXD A;  3PKO A;  5H9D A;  4N9U A;  2AEK A;  4NFK F;  3WCC A;  2OA6 A;  5IN8 A;  3PYA A;  1UBV A;  3OYR A;  3WSA A;  4RXA A;  2E90 A;  2OPN A;  4LLS A;  3KRC A;  3ACX A;  3AE0 A;  2RAH A;  4NFI F;  3LEE A;  2O1O A;  4EA0 A;  5ER8 A;  5E8L A;  4H5E F;  1HXA A;  2OGD A;  1WKZ A;  5AHU B;  2DH4 A;  5HNA A;  1YHK A;  3N6K F;  4KQS A;  4DEM F;  1UBX A;  3SAE A;  5C05 A;  3ICK A;  4MC0 A;  3Q1O A;  3EGT A;  5ILI A;  1VG6 A;  4F62 A;  3PYB A;  5JV1 F;  3KRF B;  5HN7 A;  1YYT A;  2F7M F;  3M02 A;  4WK5 A;  2F8C F;  2Z4Y A;  5ILH A;  3LJI A;  2J1P A;  4KVW A;  2J1O A;  3LK5 A;  5JV2 F;  3ZMB A;  1N1Z A;  5B03 A;  3BNY A;  3LDW A;  4OKM A;  4NG6 A;  1HM7 A;  5DGM F;  5HN8 A;  3SDV A;  3NPK A;  4LUU A;  3ICM A;  1DI1 A;  4JZX A;  4L2X F;  1WL2 A;  5A0K A;  1YV5 A;  3LOM A;  4LFV F;  5ILZ A;  4KQU A;  5B0J A;  3KRC B;  5EAU A;  1N21 A;  1N24 A;  3P8L A;  4JVJ F;  3WEI A;  4KWD A;  1RTR A;  5AEL A;  3LVS A;  1N22 A;  2E95 A;  1PS1 A;  5DJV F;  3DYF A;  2AZL A;  4DZW A;  2ONG A;  3ZL6 A;  5B00 A;  1JFG A;  4UMJ A;  3ICN A;  4E1E A;  1HXC A;  2J5C A;  3BNX A;  3OAC A;  5I1U A;  4FJQ A;  3LG5 A;  1YHM A;  3LSN A;  3N49 F;  1YYQ A;  3V1V A;  5IKA A;  5B0I A;  2ZEV A;  3N0G A;  3RMG A;  3NRI A;  5ILJ A;  5B01 A;  2AZJ A;  4MC3 A;  4QPF A;  2E8U A;  4LPG F;  4H5C F;  4E9U A;  5DJP F;  5IL3 A;  3LLW A;  3ACW A;  2FTZ A;  5ERN A;  3WJK A;  2Z7H A;  5E8H A;  2E8V A;  3TC1 A;  1VG3 A;  3ID0 A;  1YJ4 A;  4LZC A;  2EWG A;  3Q2Q A;  5IK9 A;  4RYP A;  3WCI A;  3VJC A;  3PH7 A;  2OPM A;  3VJB A;  1FPS A;  3P8R A;  1RQJ A;  3CP6 A;  1YQ7 A;  3WCJ A;  3N3D A;  4LFE A;  3S4J A;  3ASX A;  3WEH A;  3ICZ A;  3W7F A;  3G4D A;  5IMN A;  1UBW A;  3P5P A;  3M0G A;  2E94 A;  5ILK A;  2AEL A;  3B7L A;  3CKE A;  2Q9Z A;  4OMG A;  3KRA A;  4LFG A;  5DGS F;  3UCA A;  4LTZ A;  3WJO A;  3AQB B;  1YYU A;  2ZCQ A;  3NPR A;  4LA5 A;  4NKE A;  5EAT A;  2Z4V A;  3Q30 A;  4LOB A;  1V4E A;  3WJN A;  2Q58 A;  3NF2 A;  4PVY F;  3WCA A;  3N46 F;  1VG7 A;  5DW7 A;  4P0X A;  2Z7I A;  3WCG A;  4DHD A;  3LZ9 A;  1N20 A;  2PS5 A;  3SDR A;  3KBK A;  5DZ2 A;  3KRO A;  1WY0 A;  3N45 F;  5B0M A;  5ILY A;  4KPD A;  2Z4Z A;  5IMP A;  1ZW5 A;  5ERO A;  4DWG A;  3N0F A;  3WSB A;  2E8X A;  5DJR F;  5A0I A;  5HN9 A;  3QKC A;  2PS7 A;  3WE9 A;  3WEJ A;  1WL3 A;  3M9U A;  3KRP A;  5IK6 A;  4OKZ A;  2Z78 A;  4EA2 A;  3SDT A;  5B0K A;  1KIY A;  3WEF A;  2F92 F;  3G4F A;  3LGZ B;  3ADZ A;  2AZK A;  3AQ0 A;  2E91 A;  2I19 A;  4XQR F;  5E8K A;  4RXE A;  2PS8 A;  1YYR A;  3APZ A;  1V4H A;  3WCF A;  1DGP A;  4LA6 A;  3ZMC A;  3VJE A;  3IPI A;  4LTV A;  4OGU A;  2Z50 A;  3SDQ A;  3TFN A;  1UBY A;  1N23 A;  2FOR A;  1HM4 A;  3RBM A;  3N1V F;  3TFV A;  5ILD A;  3RYW A;  3KRF A;  5KSX F;  4OMH A;  3KRO B;  3WC9 A;  4DXJ A;  3EFQ A;  3S9V A;  3QQV A;  5AFX A;  3WCM A;  3DYH A;  4JZB A;  2Q9Y A;  1WMW A;  3VJ9 A;  4P0W A;  2Z4X A;  2F8Z F;  2ZCO A;  3LMD A;  5ERM A;  3KRP B;  5DIQ F;  4NFJ F;  2Z52 A;  1RQI A;  4H5D F;  4LXW A;  2QIS A;  2ZCS A;  3Q2Z A;  3VJD A;  3AQC B;  4K10 A;  5IL8 A; 
#chains in the Genus database with same CATH topology
 4N1Z F;  3OAC B;  3ACY A;  5JV0 F;  5IK0 A;  3IBA A;  3TS7 A;  3WEK A;  2E8W A;  2F89 F;  4LZ0 A;  3V66 A;  5AYP A;  4KK2 A;  4XQS F;  3M01 A;  4F6V A;  3WCE A;  4KVY A;  2Z4W A;  5IKH A;  3WEG A;  2ZEU A;  3N5J F;  2E92 A;  2E93 A;  5B02 A;  4QXS F;  4XQT F;  1VG2 A;  4RNQ A;  3OAB A;  4GP1 A;  4JXN A;  4P0V A;  3P41 A;  5CG5 A;  2Q80 A;  4F6X A;  4LZ3 A;  2F9K F;  1HXG A;  3N1W F;  5EAS A;  4KVD A;  2E4O A;  1YYS A;  1V4I A;  1YHL A;  3N5H F;  5DGN F;  2H8O A;  4ZQ8 A;  1HX9 A;  4NKF A;  5JUZ F;  5IVG A;  4KUX A;  4E9Z A;  3KB9 A;  4KQ5 A;  3PDE A;  4LIX A;  3M00 A;  4KFA A;  5JA0 F;  3WCB A;  5A0J A;  3WCH A;  4Q23 A;  4GA3 A;  4LPH F;  3VJA A;  3EZ3 A;  3CC9 A;  3SDU A;  3ZCD A;  4PVX F;  2P1C A;  5DHI A;  2PS6 A;  5DHK A;  4MC8 A;  3VJ8 A;  4KVI A;  2VF6 A;  4KPJ A;  1EZF A;  4JYX A;  1WL0 A;  3KRA B;  1JFA A;  1VG4 A;  4LLT A;  4DWB A;  4KKM A;  1WL1 A;  2PS4 A;  2AET A;  3LGK A;  2F94 F;  3TFP A;  4RXC A;  4NUA A;  5CG6 A;  3MAV A;  5B0L A;  3OAB B;  1V4J A;  4JXY A;  4GP2 A;  1V4K A;  4GAX A;  2ZCR A;  2ONH A;  3MZV A;  3WCL A;  4FP4 A;  3RYE A;  3V1X A;  4EA1 A;  2ZY1 A;  4DI5 A;  3WCD A;  4HD1 A;  3DYG A;  1KIZ A;  5IM1 A;  3N3L F;  3ZOU A;  3P5R A;  5IMI A;  1N1B A;  2E8T A;  4RXD A;  3PKO A;  5H9D A;  4N9U A;  2AEK A;  4NFK F;  3WCC A;  2OA6 A;  5IN8 A;  3PYA A;  1UBV A;  3OYR A;  3WSA A;  4RXA A;  2E90 A;  2OPN A;  4LLS A;  3KRC A;  3ACX A;  3AE0 A;  2RAH A;  4NFI F;  3LEE A;  2O1O A;  4EA0 A;  5ER8 A;  5E8L A;  4H5E F;  1HXA A;  2OGD A;  1WKZ A;  5AHU B;  2DH4 A;  5HNA A;  1YHK A;  3N6K F;  4KQS A;  4DEM F;  1UBX A;  3SAE A;  5C05 A;  3ICK A;  4MC0 A;  3Q1O A;  3EGT A;  5ILI A;  1VG6 A;  4F62 A;  3PYB A;  5JV1 F;  3KRF B;  5HN7 A;  1YYT A;  2F7M F;  3M02 A;  4WK5 A;  2F8C F;  2Z4Y A;  5ILH A;  3LJI A;  2J1P A;  4KVW A;  2J1O A;  3LK5 A;  5JV2 F;  3ZMB A;  1N1Z A;  5B03 A;  3BNY A;  3LDW A;  4OKM A;  4NG6 A;  1HM7 A;  5DGM F;  5HN8 A;  3SDV A;  3NPK A;  4LUU A;  3ICM A;  1DI1 A;  4JZX A;  4L2X F;  1WL2 A;  5A0K A;  1YV5 A;  3LOM A;  4LFV F;  5ILZ A;  4KQU A;  5B0J A;  3KRC B;  5EAU A;  1N21 A;  1N24 A;  3P8L A;  4JVJ F;  3WEI A;  4KWD A;  1RTR A;  5AEL A;  3LVS A;  1N22 A;  2E95 A;  1PS1 A;  5DJV F;  3DYF A;  2AZL A;  4DZW A;  2ONG A;  3ZL6 A;  5B00 A;  1JFG A;  4UMJ A;  3ICN A;  4E1E A;  1HXC A;  2J5C A;  3BNX A;  3OAC A;  5I1U A;  4FJQ A;  3LG5 A;  1YHM A;  3LSN A;  3N49 F;  1YYQ A;  3V1V A;  5IKA A;  5B0I A;  2ZEV A;  3N0G A;  3RMG A;  3NRI A;  5ILJ A;  5B01 A;  2AZJ A;  4MC3 A;  4QPF A;  2E8U A;  4LPG F;  4H5C F;  4E9U A;  5DJP F;  5IL3 A;  3LLW A;  3ACW A;  2FTZ A;  5ERN A;  3WJK A;  2Z7H A;  5E8H A;  2E8V A;  3TC1 A;  1VG3 A;  3ID0 A;  1YJ4 A;  4LZC A;  2EWG A;  3Q2Q A;  5IK9 A;  4RYP A;  3WCI A;  3VJC A;  3PH7 A;  2OPM A;  3VJB A;  1FPS A;  3P8R A;  1RQJ A;  3CP6 A;  1YQ7 A;  3WCJ A;  3N3D A;  4LFE A;  3S4J A;  3ASX A;  3WEH A;  3ICZ A;  3W7F A;  3G4D A;  5IMN A;  1UBW A;  3P5P A;  3M0G A;  2E94 A;  5ILK A;  2AEL A;  3B7L A;  3CKE A;  2Q9Z A;  4OMG A;  3KRA A;  4LFG A;  5DGS F;  3UCA A;  4LTZ A;  3WJO A;  3AQB B;  1YYU A;  2ZCQ A;  3NPR A;  4LA5 A;  4NKE A;  5EAT A;  2Z4V A;  3Q30 A;  4LOB A;  1V4E A;  3WJN A;  2Q58 A;  3NF2 A;  4PVY F;  3WCA A;  3N46 F;  1VG7 A;  5DW7 A;  4P0X A;  2Z7I A;  3WCG A;  4DHD A;  3LZ9 A;  1N20 A;  2PS5 A;  3SDR A;  3KBK A;  5DZ2 A;  3KRO A;  1WY0 A;  3N45 F;  5B0M A;  5ILY A;  4KPD A;  2Z4Z A;  5IMP A;  1ZW5 A;  5ERO A;  4DWG A;  3N0F A;  3WSB A;  2E8X A;  5DJR F;  5A0I A;  5HN9 A;  3QKC A;  2PS7 A;  3WE9 A;  3WEJ A;  1WL3 A;  3M9U A;  3KRP A;  5IK6 A;  4OKZ A;  2Z78 A;  4EA2 A;  3SDT A;  5B0K A;  1KIY A;  3WEF A;  2F92 F;  3G4F A;  3LGZ B;  3ADZ A;  2AZK A;  3AQ0 A;  2E91 A;  2I19 A;  4XQR F;  5E8K A;  4RXE A;  2PS8 A;  1YYR A;  3APZ A;  1V4H A;  3WCF A;  1DGP A;  4LA6 A;  3ZMC A;  3VJE A;  3IPI A;  4LTV A;  4OGU A;  2Z50 A;  3SDQ A;  3TFN A;  1UBY A;  1N23 A;  2FOR A;  1HM4 A;  3RBM A;  3N1V F;  3TFV A;  5ILD A;  3RYW A;  3KRF A;  5KSX F;  4OMH A;  3KRO B;  3WC9 A;  4DXJ A;  3EFQ A;  3S9V A;  3QQV A;  5AFX A;  3WCM A;  3DYH A;  4JZB A;  2Q9Y A;  1WMW A;  3VJ9 A;  4P0W A;  2Z4X A;  2F8Z F;  2ZCO A;  3LMD A;  5ERM A;  3KRP B;  5DIQ F;  4NFJ F;  2Z52 A;  1RQI A;  4H5D F;  4LXW A;  2QIS A;  2ZCS A;  3Q2Z A;  3VJD A;  3AQC B;  4K10 A;  5IL8 A; 
#chains in the Genus database with same CATH homology
 4N1Z F;  3OAC B;  3ACY A;  5JV0 F;  5IK0 A;  3IBA A;  3TS7 A;  3WEK A;  2E8W A;  2F89 F;  4LZ0 A;  3V66 A;  5AYP A;  4KK2 A;  4XQS F;  3M01 A;  4F6V A;  3WCE A;  4KVY A;  2Z4W A;  5IKH A;  3WEG A;  2ZEU A;  3N5J F;  2E92 A;  2E93 A;  5B02 A;  4QXS F;  4XQT F;  1VG2 A;  4RNQ A;  3OAB A;  4GP1 A;  4JXN A;  4P0V A;  3P41 A;  5CG5 A;  2Q80 A;  4F6X A;  4LZ3 A;  2F9K F;  1HXG A;  3N1W F;  5EAS A;  4KVD A;  2E4O A;  1YYS A;  1V4I A;  1YHL A;  3N5H F;  5DGN F;  2H8O A;  4ZQ8 A;  1HX9 A;  4NKF A;  5JUZ F;  5IVG A;  4KUX A;  4E9Z A;  3KB9 A;  4KQ5 A;  3PDE A;  4LIX A;  3M00 A;  4KFA A;  5JA0 F;  3WCB A;  5A0J A;  3WCH A;  4Q23 A;  4GA3 A;  4LPH F;  3VJA A;  3EZ3 A;  3CC9 A;  3SDU A;  3ZCD A;  4PVX F;  2P1C A;  5DHI A;  2PS6 A;  5DHK A;  4MC8 A;  3VJ8 A;  4KVI A;  2VF6 A;  4KPJ A;  1EZF A;  4JYX A;  1WL0 A;  3KRA B;  1JFA A;  1VG4 A;  4LLT A;  4DWB A;  4KKM A;  1WL1 A;  2PS4 A;  2AET A;  3LGK A;  2F94 F;  3TFP A;  4RXC A;  4NUA A;  5CG6 A;  3MAV A;  5B0L A;  3OAB B;  1V4J A;  4JXY A;  4GP2 A;  1V4K A;  4GAX A;  2ZCR A;  2ONH A;  3MZV A;  3WCL A;  4FP4 A;  3RYE A;  3V1X A;  4EA1 A;  2ZY1 A;  4DI5 A;  3WCD A;  4HD1 A;  3DYG A;  1KIZ A;  5IM1 A;  3N3L F;  3ZOU A;  3P5R A;  5IMI A;  1N1B A;  2E8T A;  4RXD A;  3PKO A;  5H9D A;  4N9U A;  2AEK A;  4NFK F;  3WCC A;  2OA6 A;  5IN8 A;  3PYA A;  1UBV A;  3OYR A;  3WSA A;  4RXA A;  2E90 A;  2OPN A;  4LLS A;  3KRC A;  3ACX A;  3AE0 A;  2RAH A;  4NFI F;  3LEE A;  2O1O A;  4EA0 A;  5ER8 A;  5E8L A;  4H5E F;  1HXA A;  2OGD A;  1WKZ A;  5AHU B;  2DH4 A;  5HNA A;  1YHK A;  3N6K F;  4KQS A;  4DEM F;  1UBX A;  3SAE A;  5C05 A;  3ICK A;  4MC0 A;  3Q1O A;  3EGT A;  5ILI A;  1VG6 A;  4F62 A;  3PYB A;  5JV1 F;  3KRF B;  5HN7 A;  1YYT A;  2F7M F;  3M02 A;  4WK5 A;  2F8C F;  2Z4Y A;  5ILH A;  3LJI A;  2J1P A;  4KVW A;  2J1O A;  3LK5 A;  5JV2 F;  3ZMB A;  1N1Z A;  5B03 A;  3BNY A;  3LDW A;  4OKM A;  4NG6 A;  1HM7 A;  5DGM F;  5HN8 A;  3SDV A;  3NPK A;  4LUU A;  3ICM A;  1DI1 A;  4JZX A;  4L2X F;  1WL2 A;  5A0K A;  1YV5 A;  3LOM A;  4LFV F;  5ILZ A;  4KQU A;  5B0J A;  3KRC B;  5EAU A;  1N21 A;  1N24 A;  3P8L A;  4JVJ F;  3WEI A;  4KWD A;  1RTR A;  5AEL A;  3LVS A;  1N22 A;  2E95 A;  1PS1 A;  5DJV F;  3DYF A;  2AZL A;  4DZW A;  2ONG A;  3ZL6 A;  5B00 A;  1JFG A;  4UMJ A;  3ICN A;  4E1E A;  1HXC A;  2J5C A;  3BNX A;  3OAC A;  5I1U A;  4FJQ A;  3LG5 A;  1YHM A;  3LSN A;  3N49 F;  1YYQ A;  3V1V A;  5IKA A;  5B0I A;  2ZEV A;  3N0G A;  3RMG A;  3NRI A;  5ILJ A;  5B01 A;  2AZJ A;  4MC3 A;  4QPF A;  2E8U A;  4LPG F;  4H5C F;  4E9U A;  5DJP F;  5IL3 A;  3LLW A;  3ACW A;  2FTZ A;  5ERN A;  3WJK A;  2Z7H A;  5E8H A;  2E8V A;  3TC1 A;  1VG3 A;  3ID0 A;  1YJ4 A;  4LZC A;  2EWG A;  3Q2Q A;  5IK9 A;  4RYP A;  3WCI A;  3VJC A;  3PH7 A;  2OPM A;  3VJB A;  1FPS A;  3P8R A;  1RQJ A;  3CP6 A;  1YQ7 A;  3WCJ A;  3N3D A;  4LFE A;  3S4J A;  3ASX A;  3WEH A;  3ICZ A;  3W7F A;  3G4D A;  5IMN A;  1UBW A;  3P5P A;  3M0G A;  2E94 A;  5ILK A;  2AEL A;  3B7L A;  3CKE A;  2Q9Z A;  4OMG A;  3KRA A;  4LFG A;  5DGS F;  3UCA A;  4LTZ A;  3WJO A;  3AQB B;  1YYU A;  2ZCQ A;  3NPR A;  4LA5 A;  4NKE A;  5EAT A;  2Z4V A;  3Q30 A;  4LOB A;  1V4E A;  3WJN A;  2Q58 A;  3NF2 A;  4PVY F;  3WCA A;  3N46 F;  1VG7 A;  5DW7 A;  4P0X A;  2Z7I A;  3WCG A;  4DHD A;  3LZ9 A;  1N20 A;  2PS5 A;  3SDR A;  3KBK A;  5DZ2 A;  3KRO A;  1WY0 A;  3N45 F;  5B0M A;  5ILY A;  4KPD A;  2Z4Z A;  5IMP A;  1ZW5 A;  5ERO A;  4DWG A;  3N0F A;  3WSB A;  2E8X A;  5DJR F;  5A0I A;  5HN9 A;  3QKC A;  2PS7 A;  3WE9 A;  3WEJ A;  1WL3 A;  3M9U A;  3KRP A;  5IK6 A;  4OKZ A;  2Z78 A;  4EA2 A;  3SDT A;  5B0K A;  1KIY A;  3WEF A;  2F92 F;  3G4F A;  3LGZ B;  3ADZ A;  2AZK A;  3AQ0 A;  2E91 A;  2I19 A;  4XQR F;  5E8K A;  4RXE A;  2PS8 A;  1YYR A;  3APZ A;  1V4H A;  3WCF A;  1DGP A;  4LA6 A;  3ZMC A;  3VJE A;  3IPI A;  4LTV A;  4OGU A;  2Z50 A;  3SDQ A;  3TFN A;  1UBY A;  1N23 A;  2FOR A;  1HM4 A;  3RBM A;  3N1V F;  3TFV A;  5ILD A;  3RYW A;  3KRF A;  5KSX F;  4OMH A;  3KRO B;  3WC9 A;  4DXJ A;  3EFQ A;  3S9V A;  3QQV A;  5AFX A;  3WCM A;  3DYH A;  4JZB A;  2Q9Y A;  1WMW A;  3VJ9 A;  4P0W A;  2Z4X A;  2F8Z F;  2ZCO A;  3LMD A;  5ERM A;  3KRP B;  5DIQ F;  4NFJ F;  2Z52 A;  1RQI A;  4H5D F;  4LXW A;  2QIS A;  2ZCS A;  3Q2Z A;  3VJD A;  3AQC B;  4K10 A;  5IL8 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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