4JZXA

Crystal structure of leshmaniasis major farnesyl diphosphate synthase in complex with 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, ipp and ca2+
Total Genus 156
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
156
sequence length
361
structure length
361
Chain Sequence
AHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAEAMAKDTQMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVTAQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKLDAKVAHANTTDYVEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTLEKVDKKATHKVAMVMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGSTDPAAVAVIKQLYTEQNLLARFEEYEKAVVAEVEQLIAALEAQNAAFAASVKVLWSKTYKRQK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/transferase inhibitor
source organism Leishmania major
publication title Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.
pubmed doi rcsb
molecule keywords Farnesyl pyrophosphate synthase
total genus 156
structure length 361
sequence length 361
chains with identical sequence B
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2013-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4jzxA00
4EA2A 4K10A 2F7MF 4KPDA 4E1EA 4KFAA 2OGDA 1HXCA 2H8OA 3TC1A 1HXAA 3ZMCA 3AQCB 5JUZF 3Q2ZA 3ZCDA 1WL2A 4LFEA 2AZKA 3SDQA 3ID0A 5B00A 3MZVA 1YYSA 3CKEA 2F89F 5IK6A 5B0MA 5AFXA 4KUXA 2E8XA 3VJCA 5A0IA 4MC3A 1YQ7A 1YYUA 5B0KA 3WCAA 3KRCA 3W7FA 1VG4A 3N46F 1ZW5A 3ICZA 1YHMA 5IK0A 4LFVF 2OPMA 3WCJA 4EA0A 3VJ8A 3G4FA 5ILYA 5A0JA 5A0KA 5DJRF 1UBVA 4KVIA 3AQBB 4LIXA 2Z4YA 5JV0F 5HNAA 2ZCSA 3N0FA 2FTZA 4P0VA 1YYRA 5EASA 4L2XF 1YYQA 4LLTA 5IMNA 3PDEA 4KWDA 4KKMA 1YHKA 3BNXA 4LA6A 5DZ2A 1UBXA 5B0JA 3TFVA 4OGUA 3LOMA 4F6VA 3KROA 5ER8A 4DWBA 3N3LF 5CG5A 2AETA 4GA3A 2DH4A 1FPSA 5DGNF 1DI1A 4JYXA 2E92A 2P1CA 5IMPA 5B03A 2Z78A 2E94A 3EZ3A 2J1OA 5ILKA 4PVXF 3KRCB 5JV1F 4LFGA 1HM7A 1N20A 3N0GA 2Z4WA 3N49F 5DJVF 5IM1A 4KQSA 4P0WA 4JVJF 1KIYA 3LGZB 5CG6A 3ADZA 3N1WF 5E8HA 3OYRA 3WEJA 3APZA 3ICNA 3VJ9A 4LXWA 2Z4XA 5JA0F 3SDRA 3WJOA 4KVYA 1RTRA 3AE0A 1HXGA 2E90A 5DW7A 5DJPF 1V4IA 3SDVA 2Q9ZA 3WCHA 4NKEA 4F6XA 4LOBA 2ZY1A 2Z7IA 3KRFA 3WEHA 3KRAA 2AZJA 1VG7A 4LZ0A 1VG2A 3WSAA 5IN8A 3WCCA 3OABB 2OA6A 3ICKA 3WCBA 3M00A 4NFJF 1YHLA 3N45F 4FJQA 1N23A 5I1UA 1YJ4A 5IVGA 5ILZA 3LDWA 3RMGA 3P8LA 3CP6A 3PKOA 4OKMA 3DYHA 3KRPB 3SDTA 3KB9A 3VJDA 4H5EF 1RQIA 2ZCOA 3ZL6A 3DYGA 3G4DA 4OMGA 2PS7A 3CC9A 5H9DA 4LTVA 3VJBA 4MC8A 3NRIA 2PS4A 5B0IA 1YV5A 3WCIA 1KIZA 2J5CA 4H5DF 3EFQA 2ONGA 3WJKA 3V1XA 3DYFA 4RXAA 1V4JA 4E9ZA 3M01A 4WK5A 3RBMA 2OPNA 3LG5A 2PS8A 3WJNA 4JXNA 4NG6A 3P8RA 3WCDA 2F8CF 4UMJA 4LTZA 3LVSA 4RXDA 3EGTA 1N1BA 4QPFA 4DHDA 3LK5A 4XQRF 1V4KA 1WL0A 4EA1A 3LLWA 4KQUA 1VG3A 3IBAA 5ILJA 3V1VA 5E8KA 1RQJA 1WMWA 3WCGA 4GP1A 3WCMA 2E93A 4DZWA 3S4JA 1YYTA 4PVYF 3ICMA 3PYBA 3NPRA 2O1OA 2E91A 1N22A 1V4HA 3M9UA 4P0XA 2ZCRA 4LLSA 2Q9YA 5EAUA 3P5RA 5ERNA 2Z4ZA 5E8LA 2AZLA 3ACXA 5DHIA 3ZMBA 3WEIA 4OKZA 2I19A 2E95A 3LMDA 3N5JF 3N5HF 3QKCA 4Q23A 2F8ZF 3M0GA 4DEMF 4KVDA 2E4OA 1WL3A 2QISA 5KSXF 1JFAA 3TS7A 3AQ0A 4H5CF 3KROB 3VJAA 2AEKA 3NF2A 4MC0A 3B7LA 2AELA 2J1PA 3KBKA 3WE9A 4LA5A 4LPGF 1JFGA 3ASXA 2FORA 3M02A 4JZXA 5IKHA 2ZEUA 4DWGA 4LUUA 3WCLA 4RYPA 4DI5A 3LZ9A 3Q1OA 4N9UA 2PS6A 5B01A 1UBWA 4LPHF 1HM4A 3P5PA 4FP4A 4N1ZF 4OMHA 2F9KF 5DGMF 3S9VA 1PS1A 4E9UA 3SDUA 4NUAA 2E8VA 4LZ3A 4DXJA 3ZOUA 3WEGA 3Q2QA 3UCAA 3IPIA 1N24A 5DIQF 4XQTF 2E8UA 4KQ5A 5EROA 3LEEA 2RAHA 3V66A 3WCEA 4XQSF 3NPKA 4GAXA 1VG6A 5EATA 5ILDA 1WKZA 3KRFB 2Q80A 3OACA 3KRAB 3N1VF 5ILIA 3QQVA 1V4EA 5JV2F 3P41A 2ZEVA 5AYPA 5DGSF 5B02A 3N6KF 2Z52A 5ILHA 5B0LA 1N21A 5DHKA 1EZFA 4RNQA 4RXCA 5HN8A 1DGPA 4LZCA 5AHUB 5ERMA 2PS5A 2Z4VA 2Q58A 4ZQ8A 3ACYA 3VJEA 5IL8A 3TFNA 5HN7A 4NFIF 4RXEA 4KPJA 2ZCQA 3PYAA 3SAEA 1WY0A 2EWGA 3WEFA 1UBYA 3WEKA 4QXSF 1N1ZA 1WL1A 4NKFA 3TFPA 2VF6A 3OABA 2E8TA 3WC9A 5C05A 4NFKF 3RYEA 2F94F 3BNYA 2Z50A 4JXYA 3LJIA 3OACB 5IL3A 3ACWA 5IKAA 3LSNA 4JZBA 3PH7A 2ONHA 3RYWA 4HD1A 4KVWA 4F62A 1HX9A 2F92F 3KRPA 4GP2A 5HN9A 3WSBA 3Q30A 3MAVA 3N3DA 2E8WA 4KK2A 5IMIA 3WCFA 5IK9A 5AELA 3LGKA 2Z7HA
chains in the Genus database with same CATH superfamily
4EA2A 4K10A 2F7MF 4KPDA 4E1EA 4KFAA 2OGDA 1HXCA 2H8OA 3TC1A 1HXAA 3ZMCA 3AQCB 5JUZF 3Q2ZA 3ZCDA 1WL2A 4LFEA 2AZKA 3SDQA 3ID0A 5B00A 3MZVA 1YYSA 3CKEA 2F89F 5IK6A 5B0MA 5AFXA 4KUXA 2E8XA 3VJCA 5A0IA 4MC3A 1YQ7A 1YYUA 5B0KA 3WCAA 3KRCA 3W7FA 1VG4A 3N46F 1ZW5A 3ICZA 1YHMA 5IK0A 4LFVF 2OPMA 3WCJA 4EA0A 3VJ8A 3G4FA 5ILYA 5A0JA 5A0KA 5DJRF 1UBVA 4KVIA 3AQBB 4LIXA 2Z4YA 5JV0F 5HNAA 2ZCSA 3N0FA 2FTZA 4P0VA 1YYRA 5EASA 4L2XF 1YYQA 4LLTA 5IMNA 3PDEA 4KWDA 4KKMA 1YHKA 3BNXA 4LA6A 5DZ2A 1UBXA 5B0JA 3TFVA 4OGUA 3LOMA 4F6VA 3KROA 5ER8A 4DWBA 3N3LF 5CG5A 2AETA 4GA3A 2DH4A 1FPSA 5DGNF 1DI1A 4JYXA 2E92A 2P1CA 5IMPA 5B03A 2Z78A 2E94A 3EZ3A 2J1OA 5ILKA 4PVXF 3KRCB 5JV1F 4LFGA 1HM7A 1N20A 3N0GA 2Z4WA 3N49F 5DJVF 5IM1A 4KQSA 4P0WA 4JVJF 1KIYA 3LGZB 5CG6A 3ADZA 3N1WF 5E8HA 3OYRA 3WEJA 3APZA 3ICNA 3VJ9A 4LXWA 2Z4XA 5JA0F 3SDRA 3WJOA 4KVYA 1RTRA 3AE0A 1HXGA 2E90A 5DW7A 5DJPF 1V4IA 3SDVA 2Q9ZA 3WCHA 4NKEA 4F6XA 4LOBA 2ZY1A 2Z7IA 3KRFA 3WEHA 3KRAA 2AZJA 1VG7A 4LZ0A 1VG2A 3WSAA 5IN8A 3WCCA 3OABB 2OA6A 3ICKA 3WCBA 3M00A 4NFJF 1YHLA 3N45F 4FJQA 1N23A 5I1UA 1YJ4A 5IVGA 5ILZA 3LDWA 3RMGA 3P8LA 3CP6A 3PKOA 4OKMA 3DYHA 3KRPB 3SDTA 3KB9A 3VJDA 4H5EF 1RQIA 2ZCOA 3ZL6A 3DYGA 3G4DA 4OMGA 2PS7A 3CC9A 5H9DA 4LTVA 3VJBA 4MC8A 3NRIA 2PS4A 5B0IA 1YV5A 3WCIA 1KIZA 2J5CA 4H5DF 3EFQA 2ONGA 3WJKA 3V1XA 3DYFA 4RXAA 1V4JA 4E9ZA 3M01A 4WK5A 3RBMA 2OPNA 3LG5A 2PS8A 3WJNA 4JXNA 4NG6A 3P8RA 3WCDA 2F8CF 4UMJA 4LTZA 3LVSA 4RXDA 3EGTA 1N1BA 4QPFA 4DHDA 3LK5A 4XQRF 1V4KA 1WL0A 4EA1A 3LLWA 4KQUA 1VG3A 3IBAA 5ILJA 3V1VA 5E8KA 1RQJA 1WMWA 3WCGA 4GP1A 3WCMA 2E93A 4DZWA 3S4JA 1YYTA 4PVYF 3ICMA 3PYBA 3NPRA 2O1OA 2E91A 1N22A 1V4HA 3M9UA 4P0XA 2ZCRA 4LLSA 2Q9YA 5EAUA 3P5RA 5ERNA 2Z4ZA 5E8LA 2AZLA 3ACXA 5DHIA 3ZMBA 3WEIA 4OKZA 2I19A 2E95A 3LMDA 3N5JF 3N5HF 3QKCA 4Q23A 2F8ZF 3M0GA 4DEMF 4KVDA 2E4OA 1WL3A 2QISA 5KSXF 1JFAA 3TS7A 3AQ0A 4H5CF 3KROB 3VJAA 2AEKA 3NF2A 4MC0A 3B7LA 2AELA 2J1PA 3KBKA 3WE9A 4LA5A 4LPGF 1JFGA 3ASXA 2FORA 3M02A 4JZXA 5IKHA 2ZEUA 4DWGA 4LUUA 3WCLA 4RYPA 4DI5A 3LZ9A 3Q1OA 4N9UA 2PS6A 5B01A 1UBWA 4LPHF 1HM4A 3P5PA 4FP4A 4N1ZF 4OMHA 2F9KF 5DGMF 3S9VA 1PS1A 4E9UA 3SDUA 4NUAA 2E8VA 4LZ3A 4DXJA 3ZOUA 3WEGA 3Q2QA 3UCAA 3IPIA 1N24A 5DIQF 4XQTF 2E8UA 4KQ5A 5EROA 3LEEA 2RAHA 3V66A 3WCEA 4XQSF 3NPKA 4GAXA 1VG6A 5EATA 5ILDA 1WKZA 3KRFB 2Q80A 3OACA 3KRAB 3N1VF 5ILIA 3QQVA 1V4EA 5JV2F 3P41A 2ZEVA 5AYPA 5DGSF 5B02A 3N6KF 2Z52A 5ILHA 5B0LA 1N21A 5DHKA 1EZFA 4RNQA 4RXCA 5HN8A 1DGPA 4LZCA 5AHUB 5ERMA 2PS5A 2Z4VA 2Q58A 4ZQ8A 3ACYA 3VJEA 5IL8A 3TFNA 5HN7A 4NFIF 4RXEA 4KPJA 2ZCQA 3PYAA 3SAEA 1WY0A 2EWGA 3WEFA 1UBYA 3WEKA 4QXSF 1N1ZA 1WL1A 4NKFA 3TFPA 2VF6A 3OABA 2E8TA 3WC9A 5C05A 4NFKF 3RYEA 2F94F 3BNYA 2Z50A 4JXYA 3LJIA 3OACB 5IL3A 3ACWA 5IKAA 3LSNA 4JZBA 3PH7A 2ONHA 3RYWA 4HD1A 4KVWA 4F62A 1HX9A 2F92F 3KRPA 4GP2A 5HN9A 3WSBA 3Q30A 3MAVA 3N3DA 2E8WA 4KK2A 5IMIA 3WCFA 5IK9A 5AELA 3LGKA 2Z7HA
chains in the Genus database with same CATH topology
4EA2A 4K10A 2F7MF 4KPDA 4E1EA 4KFAA 2OGDA 1HXCA 2H8OA 3TC1A 1HXAA 3ZMCA 3AQCB 5JUZF 3Q2ZA 3ZCDA 1WL2A 4LFEA 2AZKA 3SDQA 3ID0A 5B00A 3MZVA 1YYSA 3CKEA 2F89F 5IK6A 5B0MA 5AFXA 4KUXA 2E8XA 3VJCA 5A0IA 4MC3A 1YQ7A 1YYUA 5B0KA 3WCAA 3KRCA 3W7FA 1VG4A 3N46F 1ZW5A 3ICZA 1YHMA 5IK0A 4LFVF 2OPMA 3WCJA 4EA0A 3VJ8A 3G4FA 5ILYA 5A0JA 5A0KA 5DJRF 1UBVA 4KVIA 3AQBB 4LIXA 2Z4YA 5JV0F 5HNAA 2ZCSA 3N0FA 2FTZA 4P0VA 1YYRA 5EASA 4L2XF 1YYQA 4LLTA 5IMNA 3PDEA 4KWDA 4KKMA 1YHKA 3BNXA 4LA6A 5DZ2A 1UBXA 5B0JA 3TFVA 4OGUA 3LOMA 4F6VA 3KROA 5ER8A 4DWBA 3N3LF 5CG5A 2AETA 4GA3A 2DH4A 1FPSA 5DGNF 1DI1A 4JYXA 2E92A 2P1CA 5IMPA 5B03A 2Z78A 2E94A 3EZ3A 2J1OA 5ILKA 4PVXF 3KRCB 5JV1F 4LFGA 1HM7A 1N20A 3N0GA 2Z4WA 3N49F 5DJVF 5IM1A 4KQSA 4P0WA 4JVJF 1KIYA 3LGZB 5CG6A 3ADZA 3N1WF 5E8HA 3OYRA 3WEJA 3APZA 3ICNA 3VJ9A 4LXWA 2Z4XA 5JA0F 3SDRA 3WJOA 4KVYA 1RTRA 3AE0A 1HXGA 2E90A 5DW7A 5DJPF 1V4IA 3SDVA 2Q9ZA 3WCHA 4NKEA 4F6XA 4LOBA 2ZY1A 2Z7IA 3KRFA 3WEHA 3KRAA 2AZJA 1VG7A 4LZ0A 1VG2A 3WSAA 5IN8A 3WCCA 3OABB 2OA6A 3ICKA 3WCBA 3M00A 4NFJF 1YHLA 3N45F 4FJQA 1N23A 5I1UA 1YJ4A 5IVGA 5ILZA 3LDWA 3RMGA 3P8LA 3CP6A 3PKOA 4OKMA 3DYHA 3KRPB 3SDTA 3KB9A 3VJDA 4H5EF 1RQIA 2ZCOA 3ZL6A 3DYGA 3G4DA 4OMGA 2PS7A 3CC9A 5H9DA 4LTVA 3VJBA 4MC8A 3NRIA 2PS4A 5B0IA 1YV5A 3WCIA 1KIZA 2J5CA 4H5DF 3EFQA 2ONGA 3WJKA 3V1XA 3DYFA 4RXAA 1V4JA 4E9ZA 3M01A 4WK5A 3RBMA 2OPNA 3LG5A 2PS8A 3WJNA 4JXNA 4NG6A 3P8RA 3WCDA 2F8CF 4UMJA 4LTZA 3LVSA 4RXDA 3EGTA 1N1BA 4QPFA 4DHDA 3LK5A 4XQRF 1V4KA 1WL0A 4EA1A 3LLWA 4KQUA 1VG3A 3IBAA 5ILJA 3V1VA 5E8KA 1RQJA 1WMWA 3WCGA 4GP1A 3WCMA 2E93A 4DZWA 3S4JA 1YYTA 4PVYF 3ICMA 3PYBA 3NPRA 2O1OA 2E91A 1N22A 1V4HA 3M9UA 4P0XA 2ZCRA 4LLSA 2Q9YA 5EAUA 3P5RA 5ERNA 2Z4ZA 5E8LA 2AZLA 3ACXA 5DHIA 3ZMBA 3WEIA 4OKZA 2I19A 2E95A 3LMDA 3N5JF 3N5HF 3QKCA 4Q23A 2F8ZF 3M0GA 4DEMF 4KVDA 2E4OA 1WL3A 2QISA 5KSXF 1JFAA 3TS7A 3AQ0A 4H5CF 3KROB 3VJAA 2AEKA 3NF2A 4MC0A 3B7LA 2AELA 2J1PA 3KBKA 3WE9A 4LA5A 4LPGF 1JFGA 3ASXA 2FORA 3M02A 4JZXA 5IKHA 2ZEUA 4DWGA 4LUUA 3WCLA 4RYPA 4DI5A 3LZ9A 3Q1OA 4N9UA 2PS6A 5B01A 1UBWA 4LPHF 1HM4A 3P5PA 4FP4A 4N1ZF 4OMHA 2F9KF 5DGMF 3S9VA 1PS1A 4E9UA 3SDUA 4NUAA 2E8VA 4LZ3A 4DXJA 3ZOUA 3WEGA 3Q2QA 3UCAA 3IPIA 1N24A 5DIQF 4XQTF 2E8UA 4KQ5A 5EROA 3LEEA 2RAHA 3V66A 3WCEA 4XQSF 3NPKA 4GAXA 1VG6A 5EATA 5ILDA 1WKZA 3KRFB 2Q80A 3OACA 3KRAB 3N1VF 5ILIA 3QQVA 1V4EA 5JV2F 3P41A 2ZEVA 5AYPA 5DGSF 5B02A 3N6KF 2Z52A 5ILHA 5B0LA 1N21A 5DHKA 1EZFA 4RNQA 4RXCA 5HN8A 1DGPA 4LZCA 5AHUB 5ERMA 2PS5A 2Z4VA 2Q58A 4ZQ8A 3ACYA 3VJEA 5IL8A 3TFNA 5HN7A 4NFIF 4RXEA 4KPJA 2ZCQA 3PYAA 3SAEA 1WY0A 2EWGA 3WEFA 1UBYA 3WEKA 4QXSF 1N1ZA 1WL1A 4NKFA 3TFPA 2VF6A 3OABA 2E8TA 3WC9A 5C05A 4NFKF 3RYEA 2F94F 3BNYA 2Z50A 4JXYA 3LJIA 3OACB 5IL3A 3ACWA 5IKAA 3LSNA 4JZBA 3PH7A 2ONHA 3RYWA 4HD1A 4KVWA 4F62A 1HX9A 2F92F 3KRPA 4GP2A 5HN9A 3WSBA 3Q30A 3MAVA 3N3DA 2E8WA 4KK2A 5IMIA 3WCFA 5IK9A 5AELA 3LGKA 2Z7HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EA2 A;  4K10 A;  2F7M F;  4KPD A;  4E1E A;  4KFA A;  2OGD A;  1HXC A;  2H8O A;  3TC1 A;  1HXA A;  3ZMC A;  3AQC B;  5JUZ F;  3Q2Z A;  3ZCD A;  1WL2 A;  4LFE A;  2AZK A;  3SDQ A;  3ID0 A;  5B00 A;  3MZV A;  1YYS A;  3CKE A;  2F89 F;  5IK6 A;  5B0M A;  5AFX A;  4KUX A;  2E8X A;  3VJC A;  5A0I A;  4MC3 A;  1YQ7 A;  1YYU A;  5B0K A;  3WCA A;  3KRC A;  3W7F A;  1VG4 A;  3N46 F;  1ZW5 A;  3ICZ A;  1YHM A;  5IK0 A;  4LFV F;  2OPM A;  3WCJ A;  4EA0 A;  3VJ8 A;  3G4F A;  5ILY A;  5A0J A;  5A0K A;  5DJR F;  1UBV A;  4KVI A;  3AQB B;  4LIX A;  2Z4Y A;  5JV0 F;  5HNA A;  2ZCS A;  3N0F A;  2FTZ A;  4P0V A;  1YYR A;  5EAS A;  4L2X F;  1YYQ A;  4LLT A;  5IMN A;  3PDE A;  4KWD A;  4KKM A;  1YHK A;  3BNX A;  4LA6 A;  5DZ2 A;  1UBX A;  5B0J A;  3TFV A;  4OGU A;  3LOM A;  4F6V A;  3KRO A;  5ER8 A;  4DWB A;  3N3L F;  5CG5 A;  2AET A;  4GA3 A;  2DH4 A;  1FPS A;  5DGN F;  1DI1 A;  4JYX A;  2E92 A;  2P1C A;  5IMP A;  5B03 A;  2Z78 A;  2E94 A;  3EZ3 A;  2J1O A;  5ILK A;  4PVX F;  3KRC B;  5JV1 F;  4LFG A;  1HM7 A;  1N20 A;  3N0G A;  2Z4W A;  3N49 F;  5DJV F;  5IM1 A;  4KQS A;  4P0W A;  4JVJ F;  1KIY A;  3LGZ B;  5CG6 A;  3ADZ A;  3N1W F;  5E8H A;  3OYR A;  3WEJ A;  3APZ A;  3ICN A;  3VJ9 A;  4LXW A;  2Z4X A;  5JA0 F;  3SDR A;  3WJO A;  4KVY A;  1RTR A;  3AE0 A;  1HXG A;  2E90 A;  5DW7 A;  5DJP F;  1V4I A;  3SDV A;  2Q9Z A;  3WCH A;  4NKE A;  4F6X A;  4LOB A;  2ZY1 A;  2Z7I A;  3KRF A;  3WEH A;  3KRA A;  2AZJ A;  1VG7 A;  4LZ0 A;  1VG2 A;  3WSA A;  5IN8 A;  3WCC A;  3OAB B;  2OA6 A;  3ICK A;  3WCB A;  3M00 A;  4NFJ F;  1YHL A;  3N45 F;  4FJQ A;  1N23 A;  5I1U A;  1YJ4 A;  5IVG A;  5ILZ A;  3LDW A;  3RMG A;  3P8L A;  3CP6 A;  3PKO A;  4OKM A;  3DYH A;  3KRP B;  3SDT A;  3KB9 A;  3VJD A;  4H5E F;  1RQI A;  2ZCO A;  3ZL6 A;  3DYG A;  3G4D A;  4OMG A;  2PS7 A;  3CC9 A;  5H9D A;  4LTV A;  3VJB A;  4MC8 A;  3NRI A;  2PS4 A;  5B0I A;  1YV5 A;  3WCI A;  1KIZ A;  2J5C A;  4H5D F;  3EFQ A;  2ONG A;  3WJK A;  3V1X A;  3DYF A;  4RXA A;  1V4J A;  4E9Z A;  3M01 A;  4WK5 A;  3RBM A;  2OPN A;  3LG5 A;  2PS8 A;  3WJN A;  4JXN A;  4NG6 A;  3P8R A;  3WCD A;  2F8C F;  4UMJ A;  4LTZ A;  3LVS A;  4RXD A;  3EGT A;  1N1B A;  4QPF A;  4DHD A;  3LK5 A;  4XQR F;  1V4K A;  1WL0 A;  4EA1 A;  3LLW A;  4KQU A;  1VG3 A;  3IBA A;  5ILJ A;  3V1V A;  5E8K A;  1RQJ A;  1WMW A;  3WCG A;  4GP1 A;  3WCM A;  2E93 A;  4DZW A;  3S4J A;  1YYT A;  4PVY F;  3ICM A;  3PYB A;  3NPR A;  2O1O A;  2E91 A;  1N22 A;  1V4H A;  3M9U A;  4P0X A;  2ZCR A;  4LLS A;  2Q9Y A;  5EAU A;  3P5R A;  5ERN A;  2Z4Z A;  5E8L A;  2AZL A;  3ACX A;  5DHI A;  3ZMB A;  3WEI A;  4OKZ A;  2I19 A;  2E95 A;  3LMD A;  3N5J F;  3N5H F;  3QKC A;  4Q23 A;  2F8Z F;  3M0G A;  4DEM F;  4KVD A;  2E4O A;  1WL3 A;  2QIS A;  5KSX F;  1JFA A;  3TS7 A;  3AQ0 A;  4H5C F;  3KRO B;  3VJA A;  2AEK A;  3NF2 A;  4MC0 A;  3B7L A;  2AEL A;  2J1P A;  3KBK A;  3WE9 A;  4LA5 A;  4LPG F;  1JFG A;  3ASX A;  2FOR A;  3M02 A;  4JZX A;  5IKH A;  2ZEU A;  4DWG A;  4LUU A;  3WCL A;  4RYP A;  4DI5 A;  3LZ9 A;  3Q1O A;  4N9U A;  2PS6 A;  5B01 A;  1UBW A;  4LPH F;  1HM4 A;  3P5P A;  4FP4 A;  4N1Z F;  4OMH A;  2F9K F;  5DGM F;  3S9V A;  1PS1 A;  4E9U A;  3SDU A;  4NUA A;  2E8V A;  4LZ3 A;  4DXJ A;  3ZOU A;  3WEG A;  3Q2Q A;  3UCA A;  3IPI A;  1N24 A;  5DIQ F;  4XQT F;  2E8U A;  4KQ5 A;  5ERO A;  3LEE A;  2RAH A;  3V66 A;  3WCE A;  4XQS F;  3NPK A;  4GAX A;  1VG6 A;  5EAT A;  5ILD A;  1WKZ A;  3KRF B;  2Q80 A;  3OAC A;  3KRA B;  3N1V F;  5ILI A;  3QQV A;  1V4E A;  5JV2 F;  3P41 A;  2ZEV A;  5AYP A;  5DGS F;  5B02 A;  3N6K F;  2Z52 A;  5ILH A;  5B0L A;  1N21 A;  5DHK A;  1EZF A;  4RNQ A;  4RXC A;  5HN8 A;  1DGP A;  4LZC A;  5AHU B;  5ERM A;  2PS5 A;  2Z4V A;  2Q58 A;  4ZQ8 A;  3ACY A;  3VJE A;  5IL8 A;  3TFN A;  5HN7 A;  4NFI F;  4RXE A;  4KPJ A;  2ZCQ A;  3PYA A;  3SAE A;  1WY0 A;  2EWG A;  3WEF A;  1UBY A;  3WEK A;  4QXS F;  1N1Z A;  1WL1 A;  4NKF A;  3TFP A;  2VF6 A;  3OAB A;  2E8T A;  3WC9 A;  5C05 A;  4NFK F;  3RYE A;  2F94 F;  3BNY A;  2Z50 A;  4JXY A;  3LJI A;  3OAC B;  5IL3 A;  3ACW A;  5IKA A;  3LSN A;  4JZB A;  3PH7 A;  2ONH A;  3RYW A;  4HD1 A;  4KVW A;  4F62 A;  1HX9 A;  2F92 F;  3KRP A;  4GP2 A;  5HN9 A;  3WSB A;  3Q30 A;  3MAV A;  3N3D A;  2E8W A;  4KK2 A;  5IMI A;  3WCF A;  5IK9 A;  5AEL A;  3LGK A;  2Z7H A; 
#chains in the Genus database with same CATH topology
 4EA2 A;  4K10 A;  2F7M F;  4KPD A;  4E1E A;  4KFA A;  2OGD A;  1HXC A;  2H8O A;  3TC1 A;  1HXA A;  3ZMC A;  3AQC B;  5JUZ F;  3Q2Z A;  3ZCD A;  1WL2 A;  4LFE A;  2AZK A;  3SDQ A;  3ID0 A;  5B00 A;  3MZV A;  1YYS A;  3CKE A;  2F89 F;  5IK6 A;  5B0M A;  5AFX A;  4KUX A;  2E8X A;  3VJC A;  5A0I A;  4MC3 A;  1YQ7 A;  1YYU A;  5B0K A;  3WCA A;  3KRC A;  3W7F A;  1VG4 A;  3N46 F;  1ZW5 A;  3ICZ A;  1YHM A;  5IK0 A;  4LFV F;  2OPM A;  3WCJ A;  4EA0 A;  3VJ8 A;  3G4F A;  5ILY A;  5A0J A;  5A0K A;  5DJR F;  1UBV A;  4KVI A;  3AQB B;  4LIX A;  2Z4Y A;  5JV0 F;  5HNA A;  2ZCS A;  3N0F A;  2FTZ A;  4P0V A;  1YYR A;  5EAS A;  4L2X F;  1YYQ A;  4LLT A;  5IMN A;  3PDE A;  4KWD A;  4KKM A;  1YHK A;  3BNX A;  4LA6 A;  5DZ2 A;  1UBX A;  5B0J A;  3TFV A;  4OGU A;  3LOM A;  4F6V A;  3KRO A;  5ER8 A;  4DWB A;  3N3L F;  5CG5 A;  2AET A;  4GA3 A;  2DH4 A;  1FPS A;  5DGN F;  1DI1 A;  4JYX A;  2E92 A;  2P1C A;  5IMP A;  5B03 A;  2Z78 A;  2E94 A;  3EZ3 A;  2J1O A;  5ILK A;  4PVX F;  3KRC B;  5JV1 F;  4LFG A;  1HM7 A;  1N20 A;  3N0G A;  2Z4W A;  3N49 F;  5DJV F;  5IM1 A;  4KQS A;  4P0W A;  4JVJ F;  1KIY A;  3LGZ B;  5CG6 A;  3ADZ A;  3N1W F;  5E8H A;  3OYR A;  3WEJ A;  3APZ A;  3ICN A;  3VJ9 A;  4LXW A;  2Z4X A;  5JA0 F;  3SDR A;  3WJO A;  4KVY A;  1RTR A;  3AE0 A;  1HXG A;  2E90 A;  5DW7 A;  5DJP F;  1V4I A;  3SDV A;  2Q9Z A;  3WCH A;  4NKE A;  4F6X A;  4LOB A;  2ZY1 A;  2Z7I A;  3KRF A;  3WEH A;  3KRA A;  2AZJ A;  1VG7 A;  4LZ0 A;  1VG2 A;  3WSA A;  5IN8 A;  3WCC A;  3OAB B;  2OA6 A;  3ICK A;  3WCB A;  3M00 A;  4NFJ F;  1YHL A;  3N45 F;  4FJQ A;  1N23 A;  5I1U A;  1YJ4 A;  5IVG A;  5ILZ A;  3LDW A;  3RMG A;  3P8L A;  3CP6 A;  3PKO A;  4OKM A;  3DYH A;  3KRP B;  3SDT A;  3KB9 A;  3VJD A;  4H5E F;  1RQI A;  2ZCO A;  3ZL6 A;  3DYG A;  3G4D A;  4OMG A;  2PS7 A;  3CC9 A;  5H9D A;  4LTV A;  3VJB A;  4MC8 A;  3NRI A;  2PS4 A;  5B0I A;  1YV5 A;  3WCI A;  1KIZ A;  2J5C A;  4H5D F;  3EFQ A;  2ONG A;  3WJK A;  3V1X A;  3DYF A;  4RXA A;  1V4J A;  4E9Z A;  3M01 A;  4WK5 A;  3RBM A;  2OPN A;  3LG5 A;  2PS8 A;  3WJN A;  4JXN A;  4NG6 A;  3P8R A;  3WCD A;  2F8C F;  4UMJ A;  4LTZ A;  3LVS A;  4RXD A;  3EGT A;  1N1B A;  4QPF A;  4DHD A;  3LK5 A;  4XQR F;  1V4K A;  1WL0 A;  4EA1 A;  3LLW A;  4KQU A;  1VG3 A;  3IBA A;  5ILJ A;  3V1V A;  5E8K A;  1RQJ A;  1WMW A;  3WCG A;  4GP1 A;  3WCM A;  2E93 A;  4DZW A;  3S4J A;  1YYT A;  4PVY F;  3ICM A;  3PYB A;  3NPR A;  2O1O A;  2E91 A;  1N22 A;  1V4H A;  3M9U A;  4P0X A;  2ZCR A;  4LLS A;  2Q9Y A;  5EAU A;  3P5R A;  5ERN A;  2Z4Z A;  5E8L A;  2AZL A;  3ACX A;  5DHI A;  3ZMB A;  3WEI A;  4OKZ A;  2I19 A;  2E95 A;  3LMD A;  3N5J F;  3N5H F;  3QKC A;  4Q23 A;  2F8Z F;  3M0G A;  4DEM F;  4KVD A;  2E4O A;  1WL3 A;  2QIS A;  5KSX F;  1JFA A;  3TS7 A;  3AQ0 A;  4H5C F;  3KRO B;  3VJA A;  2AEK A;  3NF2 A;  4MC0 A;  3B7L A;  2AEL A;  2J1P A;  3KBK A;  3WE9 A;  4LA5 A;  4LPG F;  1JFG A;  3ASX A;  2FOR A;  3M02 A;  4JZX A;  5IKH A;  2ZEU A;  4DWG A;  4LUU A;  3WCL A;  4RYP A;  4DI5 A;  3LZ9 A;  3Q1O A;  4N9U A;  2PS6 A;  5B01 A;  1UBW A;  4LPH F;  1HM4 A;  3P5P A;  4FP4 A;  4N1Z F;  4OMH A;  2F9K F;  5DGM F;  3S9V A;  1PS1 A;  4E9U A;  3SDU A;  4NUA A;  2E8V A;  4LZ3 A;  4DXJ A;  3ZOU A;  3WEG A;  3Q2Q A;  3UCA A;  3IPI A;  1N24 A;  5DIQ F;  4XQT F;  2E8U A;  4KQ5 A;  5ERO A;  3LEE A;  2RAH A;  3V66 A;  3WCE A;  4XQS F;  3NPK A;  4GAX A;  1VG6 A;  5EAT A;  5ILD A;  1WKZ A;  3KRF B;  2Q80 A;  3OAC A;  3KRA B;  3N1V F;  5ILI A;  3QQV A;  1V4E A;  5JV2 F;  3P41 A;  2ZEV A;  5AYP A;  5DGS F;  5B02 A;  3N6K F;  2Z52 A;  5ILH A;  5B0L A;  1N21 A;  5DHK A;  1EZF A;  4RNQ A;  4RXC A;  5HN8 A;  1DGP A;  4LZC A;  5AHU B;  5ERM A;  2PS5 A;  2Z4V A;  2Q58 A;  4ZQ8 A;  3ACY A;  3VJE A;  5IL8 A;  3TFN A;  5HN7 A;  4NFI F;  4RXE A;  4KPJ A;  2ZCQ A;  3PYA A;  3SAE A;  1WY0 A;  2EWG A;  3WEF A;  1UBY A;  3WEK A;  4QXS F;  1N1Z A;  1WL1 A;  4NKF A;  3TFP A;  2VF6 A;  3OAB A;  2E8T A;  3WC9 A;  5C05 A;  4NFK F;  3RYE A;  2F94 F;  3BNY A;  2Z50 A;  4JXY A;  3LJI A;  3OAC B;  5IL3 A;  3ACW A;  5IKA A;  3LSN A;  4JZB A;  3PH7 A;  2ONH A;  3RYW A;  4HD1 A;  4KVW A;  4F62 A;  1HX9 A;  2F92 F;  3KRP A;  4GP2 A;  5HN9 A;  3WSB A;  3Q30 A;  3MAV A;  3N3D A;  2E8W A;  4KK2 A;  5IMI A;  3WCF A;  5IK9 A;  5AEL A;  3LGK A;  2Z7H A; 
#chains in the Genus database with same CATH homology
 4EA2 A;  4K10 A;  2F7M F;  4KPD A;  4E1E A;  4KFA A;  2OGD A;  1HXC A;  2H8O A;  3TC1 A;  1HXA A;  3ZMC A;  3AQC B;  5JUZ F;  3Q2Z A;  3ZCD A;  1WL2 A;  4LFE A;  2AZK A;  3SDQ A;  3ID0 A;  5B00 A;  3MZV A;  1YYS A;  3CKE A;  2F89 F;  5IK6 A;  5B0M A;  5AFX A;  4KUX A;  2E8X A;  3VJC A;  5A0I A;  4MC3 A;  1YQ7 A;  1YYU A;  5B0K A;  3WCA A;  3KRC A;  3W7F A;  1VG4 A;  3N46 F;  1ZW5 A;  3ICZ A;  1YHM A;  5IK0 A;  4LFV F;  2OPM A;  3WCJ A;  4EA0 A;  3VJ8 A;  3G4F A;  5ILY A;  5A0J A;  5A0K A;  5DJR F;  1UBV A;  4KVI A;  3AQB B;  4LIX A;  2Z4Y A;  5JV0 F;  5HNA A;  2ZCS A;  3N0F A;  2FTZ A;  4P0V A;  1YYR A;  5EAS A;  4L2X F;  1YYQ A;  4LLT A;  5IMN A;  3PDE A;  4KWD A;  4KKM A;  1YHK A;  3BNX A;  4LA6 A;  5DZ2 A;  1UBX A;  5B0J A;  3TFV A;  4OGU A;  3LOM A;  4F6V A;  3KRO A;  5ER8 A;  4DWB A;  3N3L F;  5CG5 A;  2AET A;  4GA3 A;  2DH4 A;  1FPS A;  5DGN F;  1DI1 A;  4JYX A;  2E92 A;  2P1C A;  5IMP A;  5B03 A;  2Z78 A;  2E94 A;  3EZ3 A;  2J1O A;  5ILK A;  4PVX F;  3KRC B;  5JV1 F;  4LFG A;  1HM7 A;  1N20 A;  3N0G A;  2Z4W A;  3N49 F;  5DJV F;  5IM1 A;  4KQS A;  4P0W A;  4JVJ F;  1KIY A;  3LGZ B;  5CG6 A;  3ADZ A;  3N1W F;  5E8H A;  3OYR A;  3WEJ A;  3APZ A;  3ICN A;  3VJ9 A;  4LXW A;  2Z4X A;  5JA0 F;  3SDR A;  3WJO A;  4KVY A;  1RTR A;  3AE0 A;  1HXG A;  2E90 A;  5DW7 A;  5DJP F;  1V4I A;  3SDV A;  2Q9Z A;  3WCH A;  4NKE A;  4F6X A;  4LOB A;  2ZY1 A;  2Z7I A;  3KRF A;  3WEH A;  3KRA A;  2AZJ A;  1VG7 A;  4LZ0 A;  1VG2 A;  3WSA A;  5IN8 A;  3WCC A;  3OAB B;  2OA6 A;  3ICK A;  3WCB A;  3M00 A;  4NFJ F;  1YHL A;  3N45 F;  4FJQ A;  1N23 A;  5I1U A;  1YJ4 A;  5IVG A;  5ILZ A;  3LDW A;  3RMG A;  3P8L A;  3CP6 A;  3PKO A;  4OKM A;  3DYH A;  3KRP B;  3SDT A;  3KB9 A;  3VJD A;  4H5E F;  1RQI A;  2ZCO A;  3ZL6 A;  3DYG A;  3G4D A;  4OMG A;  2PS7 A;  3CC9 A;  5H9D A;  4LTV A;  3VJB A;  4MC8 A;  3NRI A;  2PS4 A;  5B0I A;  1YV5 A;  3WCI A;  1KIZ A;  2J5C A;  4H5D F;  3EFQ A;  2ONG A;  3WJK A;  3V1X A;  3DYF A;  4RXA A;  1V4J A;  4E9Z A;  3M01 A;  4WK5 A;  3RBM A;  2OPN A;  3LG5 A;  2PS8 A;  3WJN A;  4JXN A;  4NG6 A;  3P8R A;  3WCD A;  2F8C F;  4UMJ A;  4LTZ A;  3LVS A;  4RXD A;  3EGT A;  1N1B A;  4QPF A;  4DHD A;  3LK5 A;  4XQR F;  1V4K A;  1WL0 A;  4EA1 A;  3LLW A;  4KQU A;  1VG3 A;  3IBA A;  5ILJ A;  3V1V A;  5E8K A;  1RQJ A;  1WMW A;  3WCG A;  4GP1 A;  3WCM A;  2E93 A;  4DZW A;  3S4J A;  1YYT A;  4PVY F;  3ICM A;  3PYB A;  3NPR A;  2O1O A;  2E91 A;  1N22 A;  1V4H A;  3M9U A;  4P0X A;  2ZCR A;  4LLS A;  2Q9Y A;  5EAU A;  3P5R A;  5ERN A;  2Z4Z A;  5E8L A;  2AZL A;  3ACX A;  5DHI A;  3ZMB A;  3WEI A;  4OKZ A;  2I19 A;  2E95 A;  3LMD A;  3N5J F;  3N5H F;  3QKC A;  4Q23 A;  2F8Z F;  3M0G A;  4DEM F;  4KVD A;  2E4O A;  1WL3 A;  2QIS A;  5KSX F;  1JFA A;  3TS7 A;  3AQ0 A;  4H5C F;  3KRO B;  3VJA A;  2AEK A;  3NF2 A;  4MC0 A;  3B7L A;  2AEL A;  2J1P A;  3KBK A;  3WE9 A;  4LA5 A;  4LPG F;  1JFG A;  3ASX A;  2FOR A;  3M02 A;  4JZX A;  5IKH A;  2ZEU A;  4DWG A;  4LUU A;  3WCL A;  4RYP A;  4DI5 A;  3LZ9 A;  3Q1O A;  4N9U A;  2PS6 A;  5B01 A;  1UBW A;  4LPH F;  1HM4 A;  3P5P A;  4FP4 A;  4N1Z F;  4OMH A;  2F9K F;  5DGM F;  3S9V A;  1PS1 A;  4E9U A;  3SDU A;  4NUA A;  2E8V A;  4LZ3 A;  4DXJ A;  3ZOU A;  3WEG A;  3Q2Q A;  3UCA A;  3IPI A;  1N24 A;  5DIQ F;  4XQT F;  2E8U A;  4KQ5 A;  5ERO A;  3LEE A;  2RAH A;  3V66 A;  3WCE A;  4XQS F;  3NPK A;  4GAX A;  1VG6 A;  5EAT A;  5ILD A;  1WKZ A;  3KRF B;  2Q80 A;  3OAC A;  3KRA B;  3N1V F;  5ILI A;  3QQV A;  1V4E A;  5JV2 F;  3P41 A;  2ZEV A;  5AYP A;  5DGS F;  5B02 A;  3N6K F;  2Z52 A;  5ILH A;  5B0L A;  1N21 A;  5DHK A;  1EZF A;  4RNQ A;  4RXC A;  5HN8 A;  1DGP A;  4LZC A;  5AHU B;  5ERM A;  2PS5 A;  2Z4V A;  2Q58 A;  4ZQ8 A;  3ACY A;  3VJE A;  5IL8 A;  3TFN A;  5HN7 A;  4NFI F;  4RXE A;  4KPJ A;  2ZCQ A;  3PYA A;  3SAE A;  1WY0 A;  2EWG A;  3WEF A;  1UBY A;  3WEK A;  4QXS F;  1N1Z A;  1WL1 A;  4NKF A;  3TFP A;  2VF6 A;  3OAB A;  2E8T A;  3WC9 A;  5C05 A;  4NFK F;  3RYE A;  2F94 F;  3BNY A;  2Z50 A;  4JXY A;  3LJI A;  3OAC B;  5IL3 A;  3ACW A;  5IKA A;  3LSN A;  4JZB A;  3PH7 A;  2ONH A;  3RYW A;  4HD1 A;  4KVW A;  4F62 A;  1HX9 A;  2F92 F;  3KRP A;  4GP2 A;  5HN9 A;  3WSB A;  3Q30 A;  3MAV A;  3N3D A;  2E8W A;  4KK2 A;  5IMI A;  3WCF A;  5IK9 A;  5AEL A;  3LGK A;  2Z7H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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