4NG6A

The effects of lysine 200 and phenylalanine 239 farnesyl pyrophosphate synthase (fpps) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
344
structure length
344
Chain Sequence
YAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYLTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Farnesyl pyrophosphate synthase
total genus 131
structure length 344
sequence length 344
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4ng6A00
1YJ4A 5DHIA 2Q80A 4F62A 1WKZA 2P1CA 1KIYA 4N9UA 2E8TA 1ZW5A 5DZ2A 1VG7A 3SDRA 4KVWA 5IK6A 4DZWA 5CG5A 3EGTA 3BNYA 2Z4XA 3EZ3A 3WCMA 3WC9A 5B02A 1DI1A 1YV5A 3AQ0A 5JV1F 4LZCA 3WEGA 2OA6A 1UBXA 2VF6A 2Z52A 4DEMF 4LOBA 2OPNA 3KRPB 4LUUA 3ZMBA 1HXAA 2ZEUA 3N45F 3ZCDA 3M01A 5ILKA 3PYBA 3DYHA 2AZLA 3EFQA 3WCCA 4H5CF 5IKAA 4RNQA 4HD1A 2OGDA 5A0IA 3NPRA 5IMNA 3VJCA 5IK0A 4GP2A 3P8LA 4LFEA 3IBAA 4FP4A 3G4FA 3TC1A 3ADZA 3NF2A 3DYFA 3ZOUA 2AZJA 3TFPA 3KRFA 3OACB 3V1VA 4LTVA 2PS7A 3KRAA 3M0GA 3RYEA 3ICMA 1VG4A 5DGSF 4LZ3A 3VJ8A 3PDEA 1UBYA 3WCHA 3WE9A 3LDWA 3ICKA 3N6KF 2ONGA 4KK2A 5E8LA 5IVGA 3V66A 4OMHA 3APZA 5HN8A 3P41A 4EA0A 5HN9A 4KUXA 3WEFA 5CG6A 1KIZA 3WEJA 3WSBA 4OKZA 4LFVF 4N1ZF 3P8RA 2F92F 1HM7A 1YYTA 5A0JA 4LPGF 1RQIA 4P0XA 3LSNA 4OKMA 5IKHA 3B7LA 2Q58A 4EA2A 4F6XA 1HXGA 5ILYA 4KQ5A 5B03A 3WCBA 4WK5A 4Q23A 4UMJA 3OABB 4KVYA 1WY0A 2J5CA 4P0VA 1HM4A 1YYRA 3N0GA 3N46F 5JV0F 3MAVA 1UBWA 2E8VA 1VG2A 3WJNA 4PVXF 3ICZA 5ILHA 1WL2A 3TFNA 5ILIA 1VG3A 2PS4A 4RXDA 1YQ7A 2F94F 4GA3A 3M00A 3MZVA 2Q9ZA 5B0JA 1RQJA 3KRFB 1WL3A 3LLWA 3P5PA 4ZQ8A 4XQTF 2E4OA 2F89F 3KRCA 3Q2ZA 3KRAB 1YYSA 1YHMA 3IPIA 5AFXA 3LK5A 3WCAA 3N49F 5AYPA 4DWBA 2Z7IA 4JXYA 3WCJA 4RXCA 3ACXA 4RXAA 3WSAA 4E1EA 3VJ9A 5DJPF 4NKFA 4LPHF 4GP1A 4DXJA 1N20A 3LGKA 3LVSA 3OABA 5IMPA 5EROA 5DHKA 3VJAA 4QXSF 3ASXA 2EWGA 4JXNA 3Q2QA 3LMDA 4KWDA 5DJVF 1UBVA 5IL8A 4F6VA 2F7MF 1RTRA 3P5RA 4KPJA 4H5EF 3N0FA 1PS1A 1JFAA 2F9KF 3PYAA 1V4JA 3ACYA 5B0KA 2DH4A 5H9DA 1WL0A 4QPFA 2PS6A 4DHDA 2FORA 4XQSF 3PH7A 2Z4VA 4MC8A 3Q30A 3DYGA 5IMIA 5ILZA 3Q1OA 4KVIA 5AHUB 5DJRF 4E9UA 2J1OA 1N24A 5IL3A 5IK9A 3VJEA 1HX9A 2AETA 5B0IA 4NKEA 3AQBB 3WJKA 1V4IA 2PS8A 5DIQF 3KRCB 3WCFA 5B00A 3WJOA 4OMGA 3V1XA 5JUZF 1V4HA 3G4DA 3AQCB 3N1WF 5ERNA 1N23A 2E8UA 4LLSA 3KROA 3LJIA 3QKCA 4NFJF 4LFGA 4KKMA 5JV2F 2J1PA 4PVYF 3PKOA 1N1ZA 5A0KA 4P0WA 1DGPA 1N22A 2FTZA 3NPKA 4NFKF 2ZCQA 4LA5A 1N1BA 2Z78A 4LA6A 2Q9YA 5B0LA 2ONHA 5DW7A 2H8OA 2E91A 3CP6A 3KBKA 3TS7A 5E8KA 2ZY1A 3KB9A 2E8WA 4XQRF 5JA0F 3WCIA 3M9UA 4LZ0A 1VG6A 5HNAA 4JZBA 3M02A 3N5HF 2F8CF 3LZ9A 1YHLA 1EZFA 3WCEA 3WCLA 3TFVA 2ZCSA 3SDTA 3N3DA 2AELA 5I1UA 2E92A 2QISA 4KQUA 3RMGA 3UCAA 3NRIA 4RYPA 3WEHA 3AE0A 5B0MA 3SDQA 4GAXA 3S4JA 3ACWA 4FJQA 3LG5A 3N1VF 4E9ZA 3KROB 1V4EA 3WEKA 3CC9A 4NFIF 2Z50A 5IN8A 4MC3A 1N21A 5C05A 3ZL6A 4MC0A 1V4KA 5ILJA 3N3LF 5B01A 1HXCA 3OYRA 2AEKA 5ER8A 4LLTA 4KVDA 4K10A 4EA1A 1FPSA 2E93A 1YHKA 2E90A 5HN7A 1YYUA 3WCDA 1WL1A 4JYXA 2F8ZF 3WCGA 4RXEA 4NG6A 2E94A 5DGMF 3SDUA 5KSXF 1WMWA 3LEEA 4L2XF 2ZCOA 2ZEVA 5DGNF 5AELA 3N5JF 3KRPA 3W7FA 5IM1A 5ERMA 2PS5A 2E8XA 3BNXA 3ICNA 5E8HA 3WEIA 2Z4ZA 5EATA 2ZCRA 5EAUA 4KQSA 5EASA 4LTZA 4LXWA 3S9VA 4KPDA 3LOMA 2I19A 2OPMA 3RYWA 3VJDA 4KFAA 3SAEA 3VJBA 2AZKA 1JFGA 1YYQA 2Z4WA 3RBMA 4JZXA 2RAHA 3LGZB 3CKEA 2Z4YA 4NUAA 3QQVA 4DI5A 4OGUA 2E95A 5ILDA 3ZMCA 4DWGA 3OACA 4LIXA 3SDVA 3ID0A 4H5DF 2O1OA 2Z7HA 4JVJF
chains in the Genus database with same CATH superfamily
1YJ4A 5DHIA 2Q80A 4F62A 1WKZA 2P1CA 1KIYA 4N9UA 2E8TA 1ZW5A 5DZ2A 1VG7A 3SDRA 4KVWA 5IK6A 4DZWA 5CG5A 3EGTA 3BNYA 2Z4XA 3EZ3A 3WCMA 3WC9A 5B02A 1DI1A 1YV5A 3AQ0A 5JV1F 4LZCA 3WEGA 2OA6A 1UBXA 2VF6A 2Z52A 4DEMF 4LOBA 2OPNA 3KRPB 4LUUA 3ZMBA 1HXAA 2ZEUA 3N45F 3ZCDA 3M01A 5ILKA 3PYBA 3DYHA 2AZLA 3EFQA 3WCCA 4H5CF 5IKAA 4RNQA 4HD1A 2OGDA 5A0IA 3NPRA 5IMNA 3VJCA 5IK0A 4GP2A 3P8LA 4LFEA 3IBAA 4FP4A 3G4FA 3TC1A 3ADZA 3NF2A 3DYFA 3ZOUA 2AZJA 3TFPA 3KRFA 3OACB 3V1VA 4LTVA 2PS7A 3KRAA 3M0GA 3RYEA 3ICMA 1VG4A 5DGSF 4LZ3A 3VJ8A 3PDEA 1UBYA 3WCHA 3WE9A 3LDWA 3ICKA 3N6KF 2ONGA 4KK2A 5E8LA 5IVGA 3V66A 4OMHA 3APZA 5HN8A 3P41A 4EA0A 5HN9A 4KUXA 3WEFA 5CG6A 1KIZA 3WEJA 3WSBA 4OKZA 4LFVF 4N1ZF 3P8RA 2F92F 1HM7A 1YYTA 5A0JA 4LPGF 1RQIA 4P0XA 3LSNA 4OKMA 5IKHA 3B7LA 2Q58A 4EA2A 4F6XA 1HXGA 5ILYA 4KQ5A 5B03A 3WCBA 4WK5A 4Q23A 4UMJA 3OABB 4KVYA 1WY0A 2J5CA 4P0VA 1HM4A 1YYRA 3N0GA 3N46F 5JV0F 3MAVA 1UBWA 2E8VA 1VG2A 3WJNA 4PVXF 3ICZA 5ILHA 1WL2A 3TFNA 5ILIA 1VG3A 2PS4A 4RXDA 1YQ7A 2F94F 4GA3A 3M00A 3MZVA 2Q9ZA 5B0JA 1RQJA 3KRFB 1WL3A 3LLWA 3P5PA 4ZQ8A 4XQTF 2E4OA 2F89F 3KRCA 3Q2ZA 3KRAB 1YYSA 1YHMA 3IPIA 5AFXA 3LK5A 3WCAA 3N49F 5AYPA 4DWBA 2Z7IA 4JXYA 3WCJA 4RXCA 3ACXA 4RXAA 3WSAA 4E1EA 3VJ9A 5DJPF 4NKFA 4LPHF 4GP1A 4DXJA 1N20A 3LGKA 3LVSA 3OABA 5IMPA 5EROA 5DHKA 3VJAA 4QXSF 3ASXA 2EWGA 4JXNA 3Q2QA 3LMDA 4KWDA 5DJVF 1UBVA 5IL8A 4F6VA 2F7MF 1RTRA 3P5RA 4KPJA 4H5EF 3N0FA 1PS1A 1JFAA 2F9KF 3PYAA 1V4JA 3ACYA 5B0KA 2DH4A 5H9DA 1WL0A 4QPFA 2PS6A 4DHDA 2FORA 4XQSF 3PH7A 2Z4VA 4MC8A 3Q30A 3DYGA 5IMIA 5ILZA 3Q1OA 4KVIA 5AHUB 5DJRF 4E9UA 2J1OA 1N24A 5IL3A 5IK9A 3VJEA 1HX9A 2AETA 5B0IA 4NKEA 3AQBB 3WJKA 1V4IA 2PS8A 5DIQF 3KRCB 3WCFA 5B00A 3WJOA 4OMGA 3V1XA 5JUZF 1V4HA 3G4DA 3AQCB 3N1WF 5ERNA 1N23A 2E8UA 4LLSA 3KROA 3LJIA 3QKCA 4NFJF 4LFGA 4KKMA 5JV2F 2J1PA 4PVYF 3PKOA 1N1ZA 5A0KA 4P0WA 1DGPA 1N22A 2FTZA 3NPKA 4NFKF 2ZCQA 4LA5A 1N1BA 2Z78A 4LA6A 2Q9YA 5B0LA 2ONHA 5DW7A 2H8OA 2E91A 3CP6A 3KBKA 3TS7A 5E8KA 2ZY1A 3KB9A 2E8WA 4XQRF 5JA0F 3WCIA 3M9UA 4LZ0A 1VG6A 5HNAA 4JZBA 3M02A 3N5HF 2F8CF 3LZ9A 1YHLA 1EZFA 3WCEA 3WCLA 3TFVA 2ZCSA 3SDTA 3N3DA 2AELA 5I1UA 2E92A 2QISA 4KQUA 3RMGA 3UCAA 3NRIA 4RYPA 3WEHA 3AE0A 5B0MA 3SDQA 4GAXA 3S4JA 3ACWA 4FJQA 3LG5A 3N1VF 4E9ZA 3KROB 1V4EA 3WEKA 3CC9A 4NFIF 2Z50A 5IN8A 4MC3A 1N21A 5C05A 3ZL6A 4MC0A 1V4KA 5ILJA 3N3LF 5B01A 1HXCA 3OYRA 2AEKA 5ER8A 4LLTA 4KVDA 4K10A 4EA1A 1FPSA 2E93A 1YHKA 2E90A 5HN7A 1YYUA 3WCDA 1WL1A 4JYXA 2F8ZF 3WCGA 4RXEA 4NG6A 2E94A 5DGMF 3SDUA 5KSXF 1WMWA 3LEEA 4L2XF 2ZCOA 2ZEVA 5DGNF 5AELA 3N5JF 3KRPA 3W7FA 5IM1A 5ERMA 2PS5A 2E8XA 3BNXA 3ICNA 5E8HA 3WEIA 2Z4ZA 5EATA 2ZCRA 5EAUA 4KQSA 5EASA 4LTZA 4LXWA 3S9VA 4KPDA 3LOMA 2I19A 2OPMA 3RYWA 3VJDA 4KFAA 3SAEA 3VJBA 2AZKA 1JFGA 1YYQA 2Z4WA 3RBMA 4JZXA 2RAHA 3LGZB 3CKEA 2Z4YA 4NUAA 3QQVA 4DI5A 4OGUA 2E95A 5ILDA 3ZMCA 4DWGA 3OACA 4LIXA 3SDVA 3ID0A 4H5DF 2O1OA 2Z7HA 4JVJF
chains in the Genus database with same CATH topology
1YJ4A 5DHIA 2Q80A 4F62A 1WKZA 2P1CA 1KIYA 4N9UA 2E8TA 1ZW5A 5DZ2A 1VG7A 3SDRA 4KVWA 5IK6A 4DZWA 5CG5A 3EGTA 3BNYA 2Z4XA 3EZ3A 3WCMA 3WC9A 5B02A 1DI1A 1YV5A 3AQ0A 5JV1F 4LZCA 3WEGA 2OA6A 1UBXA 2VF6A 2Z52A 4DEMF 4LOBA 2OPNA 3KRPB 4LUUA 3ZMBA 1HXAA 2ZEUA 3N45F 3ZCDA 3M01A 5ILKA 3PYBA 3DYHA 2AZLA 3EFQA 3WCCA 4H5CF 5IKAA 4RNQA 4HD1A 2OGDA 5A0IA 3NPRA 5IMNA 3VJCA 5IK0A 4GP2A 3P8LA 4LFEA 3IBAA 4FP4A 3G4FA 3TC1A 3ADZA 3NF2A 3DYFA 3ZOUA 2AZJA 3TFPA 3KRFA 3OACB 3V1VA 4LTVA 2PS7A 3KRAA 3M0GA 3RYEA 3ICMA 1VG4A 5DGSF 4LZ3A 3VJ8A 3PDEA 1UBYA 3WCHA 3WE9A 3LDWA 3ICKA 3N6KF 2ONGA 4KK2A 5E8LA 5IVGA 3V66A 4OMHA 3APZA 5HN8A 3P41A 4EA0A 5HN9A 4KUXA 3WEFA 5CG6A 1KIZA 3WEJA 3WSBA 4OKZA 4LFVF 4N1ZF 3P8RA 2F92F 1HM7A 1YYTA 5A0JA 4LPGF 1RQIA 4P0XA 3LSNA 4OKMA 5IKHA 3B7LA 2Q58A 4EA2A 4F6XA 1HXGA 5ILYA 4KQ5A 5B03A 3WCBA 4WK5A 4Q23A 4UMJA 3OABB 4KVYA 1WY0A 2J5CA 4P0VA 1HM4A 1YYRA 3N0GA 3N46F 5JV0F 3MAVA 1UBWA 2E8VA 1VG2A 3WJNA 4PVXF 3ICZA 5ILHA 1WL2A 3TFNA 5ILIA 1VG3A 2PS4A 4RXDA 1YQ7A 2F94F 4GA3A 3M00A 3MZVA 2Q9ZA 5B0JA 1RQJA 3KRFB 1WL3A 3LLWA 3P5PA 4ZQ8A 4XQTF 2E4OA 2F89F 3KRCA 3Q2ZA 3KRAB 1YYSA 1YHMA 3IPIA 5AFXA 3LK5A 3WCAA 3N49F 5AYPA 4DWBA 2Z7IA 4JXYA 3WCJA 4RXCA 3ACXA 4RXAA 3WSAA 4E1EA 3VJ9A 5DJPF 4NKFA 4LPHF 4GP1A 4DXJA 1N20A 3LGKA 3LVSA 3OABA 5IMPA 5EROA 5DHKA 3VJAA 4QXSF 3ASXA 2EWGA 4JXNA 3Q2QA 3LMDA 4KWDA 5DJVF 1UBVA 5IL8A 4F6VA 2F7MF 1RTRA 3P5RA 4KPJA 4H5EF 3N0FA 1PS1A 1JFAA 2F9KF 3PYAA 1V4JA 3ACYA 5B0KA 2DH4A 5H9DA 1WL0A 4QPFA 2PS6A 4DHDA 2FORA 4XQSF 3PH7A 2Z4VA 4MC8A 3Q30A 3DYGA 5IMIA 5ILZA 3Q1OA 4KVIA 5AHUB 5DJRF 4E9UA 2J1OA 1N24A 5IL3A 5IK9A 3VJEA 1HX9A 2AETA 5B0IA 4NKEA 3AQBB 3WJKA 1V4IA 2PS8A 5DIQF 3KRCB 3WCFA 5B00A 3WJOA 4OMGA 3V1XA 5JUZF 1V4HA 3G4DA 3AQCB 3N1WF 5ERNA 1N23A 2E8UA 4LLSA 3KROA 3LJIA 3QKCA 4NFJF 4LFGA 4KKMA 5JV2F 2J1PA 4PVYF 3PKOA 1N1ZA 5A0KA 4P0WA 1DGPA 1N22A 2FTZA 3NPKA 4NFKF 2ZCQA 4LA5A 1N1BA 2Z78A 4LA6A 2Q9YA 5B0LA 2ONHA 5DW7A 2H8OA 2E91A 3CP6A 3KBKA 3TS7A 5E8KA 2ZY1A 3KB9A 2E8WA 4XQRF 5JA0F 3WCIA 3M9UA 4LZ0A 1VG6A 5HNAA 4JZBA 3M02A 3N5HF 2F8CF 3LZ9A 1YHLA 1EZFA 3WCEA 3WCLA 3TFVA 2ZCSA 3SDTA 3N3DA 2AELA 5I1UA 2E92A 2QISA 4KQUA 3RMGA 3UCAA 3NRIA 4RYPA 3WEHA 3AE0A 5B0MA 3SDQA 4GAXA 3S4JA 3ACWA 4FJQA 3LG5A 3N1VF 4E9ZA 3KROB 1V4EA 3WEKA 3CC9A 4NFIF 2Z50A 5IN8A 4MC3A 1N21A 5C05A 3ZL6A 4MC0A 1V4KA 5ILJA 3N3LF 5B01A 1HXCA 3OYRA 2AEKA 5ER8A 4LLTA 4KVDA 4K10A 4EA1A 1FPSA 2E93A 1YHKA 2E90A 5HN7A 1YYUA 3WCDA 1WL1A 4JYXA 2F8ZF 3WCGA 4RXEA 4NG6A 2E94A 5DGMF 3SDUA 5KSXF 1WMWA 3LEEA 4L2XF 2ZCOA 2ZEVA 5DGNF 5AELA 3N5JF 3KRPA 3W7FA 5IM1A 5ERMA 2PS5A 2E8XA 3BNXA 3ICNA 5E8HA 3WEIA 2Z4ZA 5EATA 2ZCRA 5EAUA 4KQSA 5EASA 4LTZA 4LXWA 3S9VA 4KPDA 3LOMA 2I19A 2OPMA 3RYWA 3VJDA 4KFAA 3SAEA 3VJBA 2AZKA 1JFGA 1YYQA 2Z4WA 3RBMA 4JZXA 2RAHA 3LGZB 3CKEA 2Z4YA 4NUAA 3QQVA 4DI5A 4OGUA 2E95A 5ILDA 3ZMCA 4DWGA 3OACA 4LIXA 3SDVA 3ID0A 4H5DF 2O1OA 2Z7HA 4JVJF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YJ4 A;  5DHI A;  2Q80 A;  4F62 A;  1WKZ A;  2P1C A;  1KIY A;  4N9U A;  2E8T A;  1ZW5 A;  5DZ2 A;  1VG7 A;  3SDR A;  4KVW A;  5IK6 A;  4DZW A;  5CG5 A;  3EGT A;  3BNY A;  2Z4X A;  3EZ3 A;  3WCM A;  3WC9 A;  5B02 A;  1DI1 A;  1YV5 A;  3AQ0 A;  5JV1 F;  4LZC A;  3WEG A;  2OA6 A;  1UBX A;  2VF6 A;  2Z52 A;  4DEM F;  4LOB A;  2OPN A;  3KRP B;  4LUU A;  3ZMB A;  1HXA A;  2ZEU A;  3N45 F;  3ZCD A;  3M01 A;  5ILK A;  3PYB A;  3DYH A;  2AZL A;  3EFQ A;  3WCC A;  4H5C F;  5IKA A;  4RNQ A;  4HD1 A;  2OGD A;  5A0I A;  3NPR A;  5IMN A;  3VJC A;  5IK0 A;  4GP2 A;  3P8L A;  4LFE A;  3IBA A;  4FP4 A;  3G4F A;  3TC1 A;  3ADZ A;  3NF2 A;  3DYF A;  3ZOU A;  2AZJ A;  3TFP A;  3KRF A;  3OAC B;  3V1V A;  4LTV A;  2PS7 A;  3KRA A;  3M0G A;  3RYE A;  3ICM A;  1VG4 A;  5DGS F;  4LZ3 A;  3VJ8 A;  3PDE A;  1UBY A;  3WCH A;  3WE9 A;  3LDW A;  3ICK A;  3N6K F;  2ONG A;  4KK2 A;  5E8L A;  5IVG A;  3V66 A;  4OMH A;  3APZ A;  5HN8 A;  3P41 A;  4EA0 A;  5HN9 A;  4KUX A;  3WEF A;  5CG6 A;  1KIZ A;  3WEJ A;  3WSB A;  4OKZ A;  4LFV F;  4N1Z F;  3P8R A;  2F92 F;  1HM7 A;  1YYT A;  5A0J A;  4LPG F;  1RQI A;  4P0X A;  3LSN A;  4OKM A;  5IKH A;  3B7L A;  2Q58 A;  4EA2 A;  4F6X A;  1HXG A;  5ILY A;  4KQ5 A;  5B03 A;  3WCB A;  4WK5 A;  4Q23 A;  4UMJ A;  3OAB B;  4KVY A;  1WY0 A;  2J5C A;  4P0V A;  1HM4 A;  1YYR A;  3N0G A;  3N46 F;  5JV0 F;  3MAV A;  1UBW A;  2E8V A;  1VG2 A;  3WJN A;  4PVX F;  3ICZ A;  5ILH A;  1WL2 A;  3TFN A;  5ILI A;  1VG3 A;  2PS4 A;  4RXD A;  1YQ7 A;  2F94 F;  4GA3 A;  3M00 A;  3MZV A;  2Q9Z A;  5B0J A;  1RQJ A;  3KRF B;  1WL3 A;  3LLW A;  3P5P A;  4ZQ8 A;  4XQT F;  2E4O A;  2F89 F;  3KRC A;  3Q2Z A;  3KRA B;  1YYS A;  1YHM A;  3IPI A;  5AFX A;  3LK5 A;  3WCA A;  3N49 F;  5AYP A;  4DWB A;  2Z7I A;  4JXY A;  3WCJ A;  4RXC A;  3ACX A;  4RXA A;  3WSA A;  4E1E A;  3VJ9 A;  5DJP F;  4NKF A;  4LPH F;  4GP1 A;  4DXJ A;  1N20 A;  3LGK A;  3LVS A;  3OAB A;  5IMP A;  5ERO A;  5DHK A;  3VJA A;  4QXS F;  3ASX A;  2EWG A;  4JXN A;  3Q2Q A;  3LMD A;  4KWD A;  5DJV F;  1UBV A;  5IL8 A;  4F6V A;  2F7M F;  1RTR A;  3P5R A;  4KPJ A;  4H5E F;  3N0F A;  1PS1 A;  1JFA A;  2F9K F;  3PYA A;  1V4J A;  3ACY A;  5B0K A;  2DH4 A;  5H9D A;  1WL0 A;  4QPF A;  2PS6 A;  4DHD A;  2FOR A;  4XQS F;  3PH7 A;  2Z4V A;  4MC8 A;  3Q30 A;  3DYG A;  5IMI A;  5ILZ A;  3Q1O A;  4KVI A;  5AHU B;  5DJR F;  4E9U A;  2J1O A;  1N24 A;  5IL3 A;  5IK9 A;  3VJE A;  1HX9 A;  2AET A;  5B0I A;  4NKE A;  3AQB B;  3WJK A;  1V4I A;  2PS8 A;  5DIQ F;  3KRC B;  3WCF A;  5B00 A;  3WJO A;  4OMG A;  3V1X A;  5JUZ F;  1V4H A;  3G4D A;  3AQC B;  3N1W F;  5ERN A;  1N23 A;  2E8U A;  4LLS A;  3KRO A;  3LJI A;  3QKC A;  4NFJ F;  4LFG A;  4KKM A;  5JV2 F;  2J1P A;  4PVY F;  3PKO A;  1N1Z A;  5A0K A;  4P0W A;  1DGP A;  1N22 A;  2FTZ A;  3NPK A;  4NFK F;  2ZCQ A;  4LA5 A;  1N1B A;  2Z78 A;  4LA6 A;  2Q9Y A;  5B0L A;  2ONH A;  5DW7 A;  2H8O A;  2E91 A;  3CP6 A;  3KBK A;  3TS7 A;  5E8K A;  2ZY1 A;  3KB9 A;  2E8W A;  4XQR F;  5JA0 F;  3WCI A;  3M9U A;  4LZ0 A;  1VG6 A;  5HNA A;  4JZB A;  3M02 A;  3N5H F;  2F8C F;  3LZ9 A;  1YHL A;  1EZF A;  3WCE A;  3WCL A;  3TFV A;  2ZCS A;  3SDT A;  3N3D A;  2AEL A;  5I1U A;  2E92 A;  2QIS A;  4KQU A;  3RMG A;  3UCA A;  3NRI A;  4RYP A;  3WEH A;  3AE0 A;  5B0M A;  3SDQ A;  4GAX A;  3S4J A;  3ACW A;  4FJQ A;  3LG5 A;  3N1V F;  4E9Z A;  3KRO B;  1V4E A;  3WEK A;  3CC9 A;  4NFI F;  2Z50 A;  5IN8 A;  4MC3 A;  1N21 A;  5C05 A;  3ZL6 A;  4MC0 A;  1V4K A;  5ILJ A;  3N3L F;  5B01 A;  1HXC A;  3OYR A;  2AEK A;  5ER8 A;  4LLT A;  4KVD A;  4K10 A;  4EA1 A;  1FPS A;  2E93 A;  1YHK A;  2E90 A;  5HN7 A;  1YYU A;  3WCD A;  1WL1 A;  4JYX A;  2F8Z F;  3WCG A;  4RXE A;  4NG6 A;  2E94 A;  5DGM F;  3SDU A;  5KSX F;  1WMW A;  3LEE A;  4L2X F;  2ZCO A;  2ZEV A;  5DGN F;  5AEL A;  3N5J F;  3KRP A;  3W7F A;  5IM1 A;  5ERM A;  2PS5 A;  2E8X A;  3BNX A;  3ICN A;  5E8H A;  3WEI A;  2Z4Z A;  5EAT A;  2ZCR A;  5EAU A;  4KQS A;  5EAS A;  4LTZ A;  4LXW A;  3S9V A;  4KPD A;  3LOM A;  2I19 A;  2OPM A;  3RYW A;  3VJD A;  4KFA A;  3SAE A;  3VJB A;  2AZK A;  1JFG A;  1YYQ A;  2Z4W A;  3RBM A;  4JZX A;  2RAH A;  3LGZ B;  3CKE A;  2Z4Y A;  4NUA A;  3QQV A;  4DI5 A;  4OGU A;  2E95 A;  5ILD A;  3ZMC A;  4DWG A;  3OAC A;  4LIX A;  3SDV A;  3ID0 A;  4H5D F;  2O1O A;  2Z7H A;  4JVJ F; 
#chains in the Genus database with same CATH topology
 1YJ4 A;  5DHI A;  2Q80 A;  4F62 A;  1WKZ A;  2P1C A;  1KIY A;  4N9U A;  2E8T A;  1ZW5 A;  5DZ2 A;  1VG7 A;  3SDR A;  4KVW A;  5IK6 A;  4DZW A;  5CG5 A;  3EGT A;  3BNY A;  2Z4X A;  3EZ3 A;  3WCM A;  3WC9 A;  5B02 A;  1DI1 A;  1YV5 A;  3AQ0 A;  5JV1 F;  4LZC A;  3WEG A;  2OA6 A;  1UBX A;  2VF6 A;  2Z52 A;  4DEM F;  4LOB A;  2OPN A;  3KRP B;  4LUU A;  3ZMB A;  1HXA A;  2ZEU A;  3N45 F;  3ZCD A;  3M01 A;  5ILK A;  3PYB A;  3DYH A;  2AZL A;  3EFQ A;  3WCC A;  4H5C F;  5IKA A;  4RNQ A;  4HD1 A;  2OGD A;  5A0I A;  3NPR A;  5IMN A;  3VJC A;  5IK0 A;  4GP2 A;  3P8L A;  4LFE A;  3IBA A;  4FP4 A;  3G4F A;  3TC1 A;  3ADZ A;  3NF2 A;  3DYF A;  3ZOU A;  2AZJ A;  3TFP A;  3KRF A;  3OAC B;  3V1V A;  4LTV A;  2PS7 A;  3KRA A;  3M0G A;  3RYE A;  3ICM A;  1VG4 A;  5DGS F;  4LZ3 A;  3VJ8 A;  3PDE A;  1UBY A;  3WCH A;  3WE9 A;  3LDW A;  3ICK A;  3N6K F;  2ONG A;  4KK2 A;  5E8L A;  5IVG A;  3V66 A;  4OMH A;  3APZ A;  5HN8 A;  3P41 A;  4EA0 A;  5HN9 A;  4KUX A;  3WEF A;  5CG6 A;  1KIZ A;  3WEJ A;  3WSB A;  4OKZ A;  4LFV F;  4N1Z F;  3P8R A;  2F92 F;  1HM7 A;  1YYT A;  5A0J A;  4LPG F;  1RQI A;  4P0X A;  3LSN A;  4OKM A;  5IKH A;  3B7L A;  2Q58 A;  4EA2 A;  4F6X A;  1HXG A;  5ILY A;  4KQ5 A;  5B03 A;  3WCB A;  4WK5 A;  4Q23 A;  4UMJ A;  3OAB B;  4KVY A;  1WY0 A;  2J5C A;  4P0V A;  1HM4 A;  1YYR A;  3N0G A;  3N46 F;  5JV0 F;  3MAV A;  1UBW A;  2E8V A;  1VG2 A;  3WJN A;  4PVX F;  3ICZ A;  5ILH A;  1WL2 A;  3TFN A;  5ILI A;  1VG3 A;  2PS4 A;  4RXD A;  1YQ7 A;  2F94 F;  4GA3 A;  3M00 A;  3MZV A;  2Q9Z A;  5B0J A;  1RQJ A;  3KRF B;  1WL3 A;  3LLW A;  3P5P A;  4ZQ8 A;  4XQT F;  2E4O A;  2F89 F;  3KRC A;  3Q2Z A;  3KRA B;  1YYS A;  1YHM A;  3IPI A;  5AFX A;  3LK5 A;  3WCA A;  3N49 F;  5AYP A;  4DWB A;  2Z7I A;  4JXY A;  3WCJ A;  4RXC A;  3ACX A;  4RXA A;  3WSA A;  4E1E A;  3VJ9 A;  5DJP F;  4NKF A;  4LPH F;  4GP1 A;  4DXJ A;  1N20 A;  3LGK A;  3LVS A;  3OAB A;  5IMP A;  5ERO A;  5DHK A;  3VJA A;  4QXS F;  3ASX A;  2EWG A;  4JXN A;  3Q2Q A;  3LMD A;  4KWD A;  5DJV F;  1UBV A;  5IL8 A;  4F6V A;  2F7M F;  1RTR A;  3P5R A;  4KPJ A;  4H5E F;  3N0F A;  1PS1 A;  1JFA A;  2F9K F;  3PYA A;  1V4J A;  3ACY A;  5B0K A;  2DH4 A;  5H9D A;  1WL0 A;  4QPF A;  2PS6 A;  4DHD A;  2FOR A;  4XQS F;  3PH7 A;  2Z4V A;  4MC8 A;  3Q30 A;  3DYG A;  5IMI A;  5ILZ A;  3Q1O A;  4KVI A;  5AHU B;  5DJR F;  4E9U A;  2J1O A;  1N24 A;  5IL3 A;  5IK9 A;  3VJE A;  1HX9 A;  2AET A;  5B0I A;  4NKE A;  3AQB B;  3WJK A;  1V4I A;  2PS8 A;  5DIQ F;  3KRC B;  3WCF A;  5B00 A;  3WJO A;  4OMG A;  3V1X A;  5JUZ F;  1V4H A;  3G4D A;  3AQC B;  3N1W F;  5ERN A;  1N23 A;  2E8U A;  4LLS A;  3KRO A;  3LJI A;  3QKC A;  4NFJ F;  4LFG A;  4KKM A;  5JV2 F;  2J1P A;  4PVY F;  3PKO A;  1N1Z A;  5A0K A;  4P0W A;  1DGP A;  1N22 A;  2FTZ A;  3NPK A;  4NFK F;  2ZCQ A;  4LA5 A;  1N1B A;  2Z78 A;  4LA6 A;  2Q9Y A;  5B0L A;  2ONH A;  5DW7 A;  2H8O A;  2E91 A;  3CP6 A;  3KBK A;  3TS7 A;  5E8K A;  2ZY1 A;  3KB9 A;  2E8W A;  4XQR F;  5JA0 F;  3WCI A;  3M9U A;  4LZ0 A;  1VG6 A;  5HNA A;  4JZB A;  3M02 A;  3N5H F;  2F8C F;  3LZ9 A;  1YHL A;  1EZF A;  3WCE A;  3WCL A;  3TFV A;  2ZCS A;  3SDT A;  3N3D A;  2AEL A;  5I1U A;  2E92 A;  2QIS A;  4KQU A;  3RMG A;  3UCA A;  3NRI A;  4RYP A;  3WEH A;  3AE0 A;  5B0M A;  3SDQ A;  4GAX A;  3S4J A;  3ACW A;  4FJQ A;  3LG5 A;  3N1V F;  4E9Z A;  3KRO B;  1V4E A;  3WEK A;  3CC9 A;  4NFI F;  2Z50 A;  5IN8 A;  4MC3 A;  1N21 A;  5C05 A;  3ZL6 A;  4MC0 A;  1V4K A;  5ILJ A;  3N3L F;  5B01 A;  1HXC A;  3OYR A;  2AEK A;  5ER8 A;  4LLT A;  4KVD A;  4K10 A;  4EA1 A;  1FPS A;  2E93 A;  1YHK A;  2E90 A;  5HN7 A;  1YYU A;  3WCD A;  1WL1 A;  4JYX A;  2F8Z F;  3WCG A;  4RXE A;  4NG6 A;  2E94 A;  5DGM F;  3SDU A;  5KSX F;  1WMW A;  3LEE A;  4L2X F;  2ZCO A;  2ZEV A;  5DGN F;  5AEL A;  3N5J F;  3KRP A;  3W7F A;  5IM1 A;  5ERM A;  2PS5 A;  2E8X A;  3BNX A;  3ICN A;  5E8H A;  3WEI A;  2Z4Z A;  5EAT A;  2ZCR A;  5EAU A;  4KQS A;  5EAS A;  4LTZ A;  4LXW A;  3S9V A;  4KPD A;  3LOM A;  2I19 A;  2OPM A;  3RYW A;  3VJD A;  4KFA A;  3SAE A;  3VJB A;  2AZK A;  1JFG A;  1YYQ A;  2Z4W A;  3RBM A;  4JZX A;  2RAH A;  3LGZ B;  3CKE A;  2Z4Y A;  4NUA A;  3QQV A;  4DI5 A;  4OGU A;  2E95 A;  5ILD A;  3ZMC A;  4DWG A;  3OAC A;  4LIX A;  3SDV A;  3ID0 A;  4H5D F;  2O1O A;  2Z7H A;  4JVJ F; 
#chains in the Genus database with same CATH homology
 1YJ4 A;  5DHI A;  2Q80 A;  4F62 A;  1WKZ A;  2P1C A;  1KIY A;  4N9U A;  2E8T A;  1ZW5 A;  5DZ2 A;  1VG7 A;  3SDR A;  4KVW A;  5IK6 A;  4DZW A;  5CG5 A;  3EGT A;  3BNY A;  2Z4X A;  3EZ3 A;  3WCM A;  3WC9 A;  5B02 A;  1DI1 A;  1YV5 A;  3AQ0 A;  5JV1 F;  4LZC A;  3WEG A;  2OA6 A;  1UBX A;  2VF6 A;  2Z52 A;  4DEM F;  4LOB A;  2OPN A;  3KRP B;  4LUU A;  3ZMB A;  1HXA A;  2ZEU A;  3N45 F;  3ZCD A;  3M01 A;  5ILK A;  3PYB A;  3DYH A;  2AZL A;  3EFQ A;  3WCC A;  4H5C F;  5IKA A;  4RNQ A;  4HD1 A;  2OGD A;  5A0I A;  3NPR A;  5IMN A;  3VJC A;  5IK0 A;  4GP2 A;  3P8L A;  4LFE A;  3IBA A;  4FP4 A;  3G4F A;  3TC1 A;  3ADZ A;  3NF2 A;  3DYF A;  3ZOU A;  2AZJ A;  3TFP A;  3KRF A;  3OAC B;  3V1V A;  4LTV A;  2PS7 A;  3KRA A;  3M0G A;  3RYE A;  3ICM A;  1VG4 A;  5DGS F;  4LZ3 A;  3VJ8 A;  3PDE A;  1UBY A;  3WCH A;  3WE9 A;  3LDW A;  3ICK A;  3N6K F;  2ONG A;  4KK2 A;  5E8L A;  5IVG A;  3V66 A;  4OMH A;  3APZ A;  5HN8 A;  3P41 A;  4EA0 A;  5HN9 A;  4KUX A;  3WEF A;  5CG6 A;  1KIZ A;  3WEJ A;  3WSB A;  4OKZ A;  4LFV F;  4N1Z F;  3P8R A;  2F92 F;  1HM7 A;  1YYT A;  5A0J A;  4LPG F;  1RQI A;  4P0X A;  3LSN A;  4OKM A;  5IKH A;  3B7L A;  2Q58 A;  4EA2 A;  4F6X A;  1HXG A;  5ILY A;  4KQ5 A;  5B03 A;  3WCB A;  4WK5 A;  4Q23 A;  4UMJ A;  3OAB B;  4KVY A;  1WY0 A;  2J5C A;  4P0V A;  1HM4 A;  1YYR A;  3N0G A;  3N46 F;  5JV0 F;  3MAV A;  1UBW A;  2E8V A;  1VG2 A;  3WJN A;  4PVX F;  3ICZ A;  5ILH A;  1WL2 A;  3TFN A;  5ILI A;  1VG3 A;  2PS4 A;  4RXD A;  1YQ7 A;  2F94 F;  4GA3 A;  3M00 A;  3MZV A;  2Q9Z A;  5B0J A;  1RQJ A;  3KRF B;  1WL3 A;  3LLW A;  3P5P A;  4ZQ8 A;  4XQT F;  2E4O A;  2F89 F;  3KRC A;  3Q2Z A;  3KRA B;  1YYS A;  1YHM A;  3IPI A;  5AFX A;  3LK5 A;  3WCA A;  3N49 F;  5AYP A;  4DWB A;  2Z7I A;  4JXY A;  3WCJ A;  4RXC A;  3ACX A;  4RXA A;  3WSA A;  4E1E A;  3VJ9 A;  5DJP F;  4NKF A;  4LPH F;  4GP1 A;  4DXJ A;  1N20 A;  3LGK A;  3LVS A;  3OAB A;  5IMP A;  5ERO A;  5DHK A;  3VJA A;  4QXS F;  3ASX A;  2EWG A;  4JXN A;  3Q2Q A;  3LMD A;  4KWD A;  5DJV F;  1UBV A;  5IL8 A;  4F6V A;  2F7M F;  1RTR A;  3P5R A;  4KPJ A;  4H5E F;  3N0F A;  1PS1 A;  1JFA A;  2F9K F;  3PYA A;  1V4J A;  3ACY A;  5B0K A;  2DH4 A;  5H9D A;  1WL0 A;  4QPF A;  2PS6 A;  4DHD A;  2FOR A;  4XQS F;  3PH7 A;  2Z4V A;  4MC8 A;  3Q30 A;  3DYG A;  5IMI A;  5ILZ A;  3Q1O A;  4KVI A;  5AHU B;  5DJR F;  4E9U A;  2J1O A;  1N24 A;  5IL3 A;  5IK9 A;  3VJE A;  1HX9 A;  2AET A;  5B0I A;  4NKE A;  3AQB B;  3WJK A;  1V4I A;  2PS8 A;  5DIQ F;  3KRC B;  3WCF A;  5B00 A;  3WJO A;  4OMG A;  3V1X A;  5JUZ F;  1V4H A;  3G4D A;  3AQC B;  3N1W F;  5ERN A;  1N23 A;  2E8U A;  4LLS A;  3KRO A;  3LJI A;  3QKC A;  4NFJ F;  4LFG A;  4KKM A;  5JV2 F;  2J1P A;  4PVY F;  3PKO A;  1N1Z A;  5A0K A;  4P0W A;  1DGP A;  1N22 A;  2FTZ A;  3NPK A;  4NFK F;  2ZCQ A;  4LA5 A;  1N1B A;  2Z78 A;  4LA6 A;  2Q9Y A;  5B0L A;  2ONH A;  5DW7 A;  2H8O A;  2E91 A;  3CP6 A;  3KBK A;  3TS7 A;  5E8K A;  2ZY1 A;  3KB9 A;  2E8W A;  4XQR F;  5JA0 F;  3WCI A;  3M9U A;  4LZ0 A;  1VG6 A;  5HNA A;  4JZB A;  3M02 A;  3N5H F;  2F8C F;  3LZ9 A;  1YHL A;  1EZF A;  3WCE A;  3WCL A;  3TFV A;  2ZCS A;  3SDT A;  3N3D A;  2AEL A;  5I1U A;  2E92 A;  2QIS A;  4KQU A;  3RMG A;  3UCA A;  3NRI A;  4RYP A;  3WEH A;  3AE0 A;  5B0M A;  3SDQ A;  4GAX A;  3S4J A;  3ACW A;  4FJQ A;  3LG5 A;  3N1V F;  4E9Z A;  3KRO B;  1V4E A;  3WEK A;  3CC9 A;  4NFI F;  2Z50 A;  5IN8 A;  4MC3 A;  1N21 A;  5C05 A;  3ZL6 A;  4MC0 A;  1V4K A;  5ILJ A;  3N3L F;  5B01 A;  1HXC A;  3OYR A;  2AEK A;  5ER8 A;  4LLT A;  4KVD A;  4K10 A;  4EA1 A;  1FPS A;  2E93 A;  1YHK A;  2E90 A;  5HN7 A;  1YYU A;  3WCD A;  1WL1 A;  4JYX A;  2F8Z F;  3WCG A;  4RXE A;  4NG6 A;  2E94 A;  5DGM F;  3SDU A;  5KSX F;  1WMW A;  3LEE A;  4L2X F;  2ZCO A;  2ZEV A;  5DGN F;  5AEL A;  3N5J F;  3KRP A;  3W7F A;  5IM1 A;  5ERM A;  2PS5 A;  2E8X A;  3BNX A;  3ICN A;  5E8H A;  3WEI A;  2Z4Z A;  5EAT A;  2ZCR A;  5EAU A;  4KQS A;  5EAS A;  4LTZ A;  4LXW A;  3S9V A;  4KPD A;  3LOM A;  2I19 A;  2OPM A;  3RYW A;  3VJD A;  4KFA A;  3SAE A;  3VJB A;  2AZK A;  1JFG A;  1YYQ A;  2Z4W A;  3RBM A;  4JZX A;  2RAH A;  3LGZ B;  3CKE A;  2Z4Y A;  4NUA A;  3QQV A;  4DI5 A;  4OGU A;  2E95 A;  5ILD A;  3ZMC A;  4DWG A;  3OAC A;  4LIX A;  3SDV A;  3ID0 A;  4H5D F;  2O1O A;  2Z7H A;  4JVJ F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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