4PVYF

Crystal structure of human fpps in complex with [({5-[4-(propan-2-yloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid)
Total Genus 140
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
140
sequence length
346
structure length
346
Chain Sequence
DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Farnesyl pyrophosphate synthase
total genus 140
structure length 346
sequence length 346
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2014-03-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4pvyF00
2E94A 4LTVA 4Q23A 3BNXA 1N23A 5IMIA 4KQUA 2QISA 3WC9A 4E1EA 4MC3A 3EGTA 4QPFA 2F9KF 4H5DF 4P0WA 3VJBA 4FJQA 4F62A 1V4EA 2FORA 3IPIA 3ZCDA 4KKMA 4LUUA 3TFPA 1UBXA 5E8KA 4KVYA 1ZW5A 1HX9A 4KPJA 1DI1A 2H8OA 3LEEA 4KVDA 5EASA 5DHIA 1YYSA 5DGNF 5ERNA 4E9ZA 2E8UA 4EA0A 5DW7A 2RAHA 3WJOA 5KSXF 4MC0A 1N1BA 4LFGA 5ER8A 2Z7HA 2Q80A 4LFVF 4DEMF 4FP4A 5HN8A 3PYBA 1KIZA 1N24A 4GAXA 2PS5A 3WEIA 2O1OA 1YYQA 3P41A 2E93A 4MC8A 5DIQF 4HD1A 1PS1A 5B0JA 3CKEA 2F8ZF 3TFNA 5IMPA 3NRIA 4DWGA 1JFGA 3LG5A 4JZBA 1HXAA 2Q9ZA 3TC1A 2E8WA 5HNAA 3N0FA 3WCIA 4NUAA 3N6KF 2J5CA 1RQIA 4KQ5A 5AYPA 3PYAA 4XQTF 3KRCA 4LPHF 3N5JF 4JVJF 3WSAA 4KFAA 5JV1F 1EZFA 3ZMCA 3KB9A 4RXDA 1HM7A 1V4HA 3WEKA 2Z4XA 3N49F 5IKAA 3MAVA 3OYRA 5JV0F 5H9DA 3VJ9A 3KROA 4LZ0A 3KRFA 4LOBA 2F7MF 4XQSF 3WEJA 5B0KA 2Z52A 2J1PA 5IK0A 3AQCB 4LZ3A 4H5CF 4LPGF 5DJPF 5B0MA 3LLWA 4OKZA 2AZJA 4XQRF 3P8LA 5AELA 5JV2F 5B0LA 3ACYA 3SDUA 3WCAA 4N1ZF 3V66A 4DWBA 2E95A 3WJKA 3CP6A 3M02A 5EATA 5B02A 3CC9A 4KVIA 2ZCOA 4N9UA 2E8XA 1JFAA 3KRCB 3NF2A 2E92A 5ILHA 4NFJF 4JYXA 2E91A 2ZEVA 4KPDA 5A0JA 3LJIA 2E4OA 2PS7A 4WK5A 3KROB 1YQ7A 1WY0A 4GA3A 4KUXA 4P0XA 3WSBA 3KRFB 4NFKF 3P5RA 4RXAA 3WEGA 4DXJA 2ZEUA 1VG7A 1YJ4A 3VJDA 2F94F 3ACWA 2F89F 5EAUA 3WCHA 2E90A 3ICMA 4JZXA 2EWGA 3M00A 5DJVF 3AQBB 3N5HF 2FTZA 4OMGA 4F6XA 2Z50A 2ZCSA 3DYFA 4OKMA 2Z4ZA 2Z7IA 3DYHA 1VG2A 3SDRA 5IK9A 5JUZF 3M01A 1WL3A 5CG6A 1FPSA 1UBVA 4H5EF 5IMNA 2E8VA 3N45F 3Q2ZA 2OA6A 5ILDA 3VJCA 1N20A 5IKHA 3SAEA 5IM1A 1YV5A 3OACA 3N3DA 4LXWA 1VG4A 2ZY1A 1RQJA 1HXCA 4E9UA 3SDTA 3LGZB 3Q1OA 3ICZA 3WCCA 5ERMA 5DZ2A 3Q30A 5B01A 5ILYA 3ICNA 4F6VA 4P0VA 5B03A 4ZQ8A 4K10A 1N1ZA 1WKZA 4NKEA 4OGUA 1N21A 3RBMA 3VJAA 2P1CA 5EROA 5B0IA 5IL8A 4LTZA 2Z78A 2ZCQA 1WL0A 3SDVA 5E8HA 3MZVA 3N0GA 2Z4YA 4LLSA 3WE9A 3UCAA 5C05A 1HM4A 3P5PA 3NPKA 2ONHA 3RYEA 5CG5A 4LIXA 2Z4WA 1V4IA 3WJNA 3ACXA 1N22A 3RMGA 4DHDA 4GP1A 4LLTA 2OGDA 3N46F 2AELA 3KRPB 3ZMBA 1YYUA 5IN8A 2OPMA 5HN9A 3V1XA 4KVWA 3NPRA 3KBKA 4JXNA 3WCDA 3OACB 4RXCA 2DH4A 4RNQA 3APZA 3WEFA 3W7FA 2ZCRA 4LFEA 2OPNA 4PVXF 3V1VA 3PH7A 3LGKA 3EFQA 1YHLA 4JXYA 2AZLA 3QKCA 3WCJA 4QXSF 3RYWA 2I19A 3OABA 3WCLA 3IBAA 2Z4VA 1UBYA 4DI5A 4LA5A 3B7LA 4OMHA 5IL3A 3ZL6A 3AQ0A 1UBWA 1RTRA 3WCEA 2Q58A 3TS7A 2PS8A 3TFVA 5IVGA 4KK2A 4LZCA 5A0KA 2F92F 5DGMF 3ZOUA 4RYPA 1VG3A 5ILIA 3WEHA 2E8TA 2J1OA 3LOMA 1WL2A 2AETA 3AE0A 3M9UA 1YHMA 5ILJA 1YHKA 3BNYA 3VJEA 3QQVA 2Q9YA 2AEKA 4NG6A 3LDWA 1DGPA 1WL1A 3KRPA 3WCMA 4EA2A 3KRAA 3ADZA 3ID0A 2VF6A 1YYRA 5IK6A 3PKOA 5JA0F 3EZ3A 2AZKA 1HXGA 3S4JA 1VG6A 3G4FA 3OABB 3SDQA 3VJ8A 4L2XF 2F8CF 3N1WF 3LSNA 5HN7A 5AHUB 5E8LA 3N3LF 3PDEA 1YYTA 3M0GA 4PVYF 3G4DA 4EA1A 4KWDA 5ILZA 2ONGA 5ILKA 5DGSF 5AFXA 3ASXA 3LVSA 4NFIF 4LA6A 5A0IA 4GP2A 3S9VA 3LMDA 1WMWA 5DJRF 3P8RA 5B00A 3WCBA 3DYGA 3ICKA 1KIYA 4UMJA 3WCGA 3Q2QA 2PS6A 2PS4A 5I1UA 3KRAB 1V4KA 5DHKA 4DZWA 3N1VF 3LZ9A 4NKFA 3LK5A 4KQSA 3WCFA 1V4JA 4RXEA
chains in the Genus database with same CATH superfamily
2E94A 4LTVA 4Q23A 3BNXA 1N23A 5IMIA 4KQUA 2QISA 3WC9A 4E1EA 4MC3A 3EGTA 4QPFA 2F9KF 4H5DF 4P0WA 3VJBA 4FJQA 4F62A 1V4EA 2FORA 3IPIA 3ZCDA 4KKMA 4LUUA 3TFPA 1UBXA 5E8KA 4KVYA 1ZW5A 1HX9A 4KPJA 1DI1A 2H8OA 3LEEA 4KVDA 5EASA 5DHIA 1YYSA 5DGNF 5ERNA 4E9ZA 2E8UA 4EA0A 5DW7A 2RAHA 3WJOA 5KSXF 4MC0A 1N1BA 4LFGA 5ER8A 2Z7HA 2Q80A 4LFVF 4DEMF 4FP4A 5HN8A 3PYBA 1KIZA 1N24A 4GAXA 2PS5A 3WEIA 2O1OA 1YYQA 3P41A 2E93A 4MC8A 5DIQF 4HD1A 1PS1A 5B0JA 3CKEA 2F8ZF 3TFNA 5IMPA 3NRIA 4DWGA 1JFGA 3LG5A 4JZBA 1HXAA 2Q9ZA 3TC1A 2E8WA 5HNAA 3N0FA 3WCIA 4NUAA 3N6KF 2J5CA 1RQIA 4KQ5A 5AYPA 3PYAA 4XQTF 3KRCA 4LPHF 3N5JF 4JVJF 3WSAA 4KFAA 5JV1F 1EZFA 3ZMCA 3KB9A 4RXDA 1HM7A 1V4HA 3WEKA 2Z4XA 3N49F 5IKAA 3MAVA 3OYRA 5JV0F 5H9DA 3VJ9A 3KROA 4LZ0A 3KRFA 4LOBA 2F7MF 4XQSF 3WEJA 5B0KA 2Z52A 2J1PA 5IK0A 3AQCB 4LZ3A 4H5CF 4LPGF 5DJPF 5B0MA 3LLWA 4OKZA 2AZJA 4XQRF 3P8LA 5AELA 5JV2F 5B0LA 3ACYA 3SDUA 3WCAA 4N1ZF 3V66A 4DWBA 2E95A 3WJKA 3CP6A 3M02A 5EATA 5B02A 3CC9A 4KVIA 2ZCOA 4N9UA 2E8XA 1JFAA 3KRCB 3NF2A 2E92A 5ILHA 4NFJF 4JYXA 2E91A 2ZEVA 4KPDA 5A0JA 3LJIA 2E4OA 2PS7A 4WK5A 3KROB 1YQ7A 1WY0A 4GA3A 4KUXA 4P0XA 3WSBA 3KRFB 4NFKF 3P5RA 4RXAA 3WEGA 4DXJA 2ZEUA 1VG7A 1YJ4A 3VJDA 2F94F 3ACWA 2F89F 5EAUA 3WCHA 2E90A 3ICMA 4JZXA 2EWGA 3M00A 5DJVF 3AQBB 3N5HF 2FTZA 4OMGA 4F6XA 2Z50A 2ZCSA 3DYFA 4OKMA 2Z4ZA 2Z7IA 3DYHA 1VG2A 3SDRA 5IK9A 5JUZF 3M01A 1WL3A 5CG6A 1FPSA 1UBVA 4H5EF 5IMNA 2E8VA 3N45F 3Q2ZA 2OA6A 5ILDA 3VJCA 1N20A 5IKHA 3SAEA 5IM1A 1YV5A 3OACA 3N3DA 4LXWA 1VG4A 2ZY1A 1RQJA 1HXCA 4E9UA 3SDTA 3LGZB 3Q1OA 3ICZA 3WCCA 5ERMA 5DZ2A 3Q30A 5B01A 5ILYA 3ICNA 4F6VA 4P0VA 5B03A 4ZQ8A 4K10A 1N1ZA 1WKZA 4NKEA 4OGUA 1N21A 3RBMA 3VJAA 2P1CA 5EROA 5B0IA 5IL8A 4LTZA 2Z78A 2ZCQA 1WL0A 3SDVA 5E8HA 3MZVA 3N0GA 2Z4YA 4LLSA 3WE9A 3UCAA 5C05A 1HM4A 3P5PA 3NPKA 2ONHA 3RYEA 5CG5A 4LIXA 2Z4WA 1V4IA 3WJNA 3ACXA 1N22A 3RMGA 4DHDA 4GP1A 4LLTA 2OGDA 3N46F 2AELA 3KRPB 3ZMBA 1YYUA 5IN8A 2OPMA 5HN9A 3V1XA 4KVWA 3NPRA 3KBKA 4JXNA 3WCDA 3OACB 4RXCA 2DH4A 4RNQA 3APZA 3WEFA 3W7FA 2ZCRA 4LFEA 2OPNA 4PVXF 3V1VA 3PH7A 3LGKA 3EFQA 1YHLA 4JXYA 2AZLA 3QKCA 3WCJA 4QXSF 3RYWA 2I19A 3OABA 3WCLA 3IBAA 2Z4VA 1UBYA 4DI5A 4LA5A 3B7LA 4OMHA 5IL3A 3ZL6A 3AQ0A 1UBWA 1RTRA 3WCEA 2Q58A 3TS7A 2PS8A 3TFVA 5IVGA 4KK2A 4LZCA 5A0KA 2F92F 5DGMF 3ZOUA 4RYPA 1VG3A 5ILIA 3WEHA 2E8TA 2J1OA 3LOMA 1WL2A 2AETA 3AE0A 3M9UA 1YHMA 5ILJA 1YHKA 3BNYA 3VJEA 3QQVA 2Q9YA 2AEKA 4NG6A 3LDWA 1DGPA 1WL1A 3KRPA 3WCMA 4EA2A 3KRAA 3ADZA 3ID0A 2VF6A 1YYRA 5IK6A 3PKOA 5JA0F 3EZ3A 2AZKA 1HXGA 3S4JA 1VG6A 3G4FA 3OABB 3SDQA 3VJ8A 4L2XF 2F8CF 3N1WF 3LSNA 5HN7A 5AHUB 5E8LA 3N3LF 3PDEA 1YYTA 3M0GA 4PVYF 3G4DA 4EA1A 4KWDA 5ILZA 2ONGA 5ILKA 5DGSF 5AFXA 3ASXA 3LVSA 4NFIF 4LA6A 5A0IA 4GP2A 3S9VA 3LMDA 1WMWA 5DJRF 3P8RA 5B00A 3WCBA 3DYGA 3ICKA 1KIYA 4UMJA 3WCGA 3Q2QA 2PS6A 2PS4A 5I1UA 3KRAB 1V4KA 5DHKA 4DZWA 3N1VF 3LZ9A 4NKFA 3LK5A 4KQSA 3WCFA 1V4JA 4RXEA
chains in the Genus database with same CATH topology
2E94A 4LTVA 4Q23A 3BNXA 1N23A 5IMIA 4KQUA 2QISA 3WC9A 4E1EA 4MC3A 3EGTA 4QPFA 2F9KF 4H5DF 4P0WA 3VJBA 4FJQA 4F62A 1V4EA 2FORA 3IPIA 3ZCDA 4KKMA 4LUUA 3TFPA 1UBXA 5E8KA 4KVYA 1ZW5A 1HX9A 4KPJA 1DI1A 2H8OA 3LEEA 4KVDA 5EASA 5DHIA 1YYSA 5DGNF 5ERNA 4E9ZA 2E8UA 4EA0A 5DW7A 2RAHA 3WJOA 5KSXF 4MC0A 1N1BA 4LFGA 5ER8A 2Z7HA 2Q80A 4LFVF 4DEMF 4FP4A 5HN8A 3PYBA 1KIZA 1N24A 4GAXA 2PS5A 3WEIA 2O1OA 1YYQA 3P41A 2E93A 4MC8A 5DIQF 4HD1A 1PS1A 5B0JA 3CKEA 2F8ZF 3TFNA 5IMPA 3NRIA 4DWGA 1JFGA 3LG5A 4JZBA 1HXAA 2Q9ZA 3TC1A 2E8WA 5HNAA 3N0FA 3WCIA 4NUAA 3N6KF 2J5CA 1RQIA 4KQ5A 5AYPA 3PYAA 4XQTF 3KRCA 4LPHF 3N5JF 4JVJF 3WSAA 4KFAA 5JV1F 1EZFA 3ZMCA 3KB9A 4RXDA 1HM7A 1V4HA 3WEKA 2Z4XA 3N49F 5IKAA 3MAVA 3OYRA 5JV0F 5H9DA 3VJ9A 3KROA 4LZ0A 3KRFA 4LOBA 2F7MF 4XQSF 3WEJA 5B0KA 2Z52A 2J1PA 5IK0A 3AQCB 4LZ3A 4H5CF 4LPGF 5DJPF 5B0MA 3LLWA 4OKZA 2AZJA 4XQRF 3P8LA 5AELA 5JV2F 5B0LA 3ACYA 3SDUA 3WCAA 4N1ZF 3V66A 4DWBA 2E95A 3WJKA 3CP6A 3M02A 5EATA 5B02A 3CC9A 4KVIA 2ZCOA 4N9UA 2E8XA 1JFAA 3KRCB 3NF2A 2E92A 5ILHA 4NFJF 4JYXA 2E91A 2ZEVA 4KPDA 5A0JA 3LJIA 2E4OA 2PS7A 4WK5A 3KROB 1YQ7A 1WY0A 4GA3A 4KUXA 4P0XA 3WSBA 3KRFB 4NFKF 3P5RA 4RXAA 3WEGA 4DXJA 2ZEUA 1VG7A 1YJ4A 3VJDA 2F94F 3ACWA 2F89F 5EAUA 3WCHA 2E90A 3ICMA 4JZXA 2EWGA 3M00A 5DJVF 3AQBB 3N5HF 2FTZA 4OMGA 4F6XA 2Z50A 2ZCSA 3DYFA 4OKMA 2Z4ZA 2Z7IA 3DYHA 1VG2A 3SDRA 5IK9A 5JUZF 3M01A 1WL3A 5CG6A 1FPSA 1UBVA 4H5EF 5IMNA 2E8VA 3N45F 3Q2ZA 2OA6A 5ILDA 3VJCA 1N20A 5IKHA 3SAEA 5IM1A 1YV5A 3OACA 3N3DA 4LXWA 1VG4A 2ZY1A 1RQJA 1HXCA 4E9UA 3SDTA 3LGZB 3Q1OA 3ICZA 3WCCA 5ERMA 5DZ2A 3Q30A 5B01A 5ILYA 3ICNA 4F6VA 4P0VA 5B03A 4ZQ8A 4K10A 1N1ZA 1WKZA 4NKEA 4OGUA 1N21A 3RBMA 3VJAA 2P1CA 5EROA 5B0IA 5IL8A 4LTZA 2Z78A 2ZCQA 1WL0A 3SDVA 5E8HA 3MZVA 3N0GA 2Z4YA 4LLSA 3WE9A 3UCAA 5C05A 1HM4A 3P5PA 3NPKA 2ONHA 3RYEA 5CG5A 4LIXA 2Z4WA 1V4IA 3WJNA 3ACXA 1N22A 3RMGA 4DHDA 4GP1A 4LLTA 2OGDA 3N46F 2AELA 3KRPB 3ZMBA 1YYUA 5IN8A 2OPMA 5HN9A 3V1XA 4KVWA 3NPRA 3KBKA 4JXNA 3WCDA 3OACB 4RXCA 2DH4A 4RNQA 3APZA 3WEFA 3W7FA 2ZCRA 4LFEA 2OPNA 4PVXF 3V1VA 3PH7A 3LGKA 3EFQA 1YHLA 4JXYA 2AZLA 3QKCA 3WCJA 4QXSF 3RYWA 2I19A 3OABA 3WCLA 3IBAA 2Z4VA 1UBYA 4DI5A 4LA5A 3B7LA 4OMHA 5IL3A 3ZL6A 3AQ0A 1UBWA 1RTRA 3WCEA 2Q58A 3TS7A 2PS8A 3TFVA 5IVGA 4KK2A 4LZCA 5A0KA 2F92F 5DGMF 3ZOUA 4RYPA 1VG3A 5ILIA 3WEHA 2E8TA 2J1OA 3LOMA 1WL2A 2AETA 3AE0A 3M9UA 1YHMA 5ILJA 1YHKA 3BNYA 3VJEA 3QQVA 2Q9YA 2AEKA 4NG6A 3LDWA 1DGPA 1WL1A 3KRPA 3WCMA 4EA2A 3KRAA 3ADZA 3ID0A 2VF6A 1YYRA 5IK6A 3PKOA 5JA0F 3EZ3A 2AZKA 1HXGA 3S4JA 1VG6A 3G4FA 3OABB 3SDQA 3VJ8A 4L2XF 2F8CF 3N1WF 3LSNA 5HN7A 5AHUB 5E8LA 3N3LF 3PDEA 1YYTA 3M0GA 4PVYF 3G4DA 4EA1A 4KWDA 5ILZA 2ONGA 5ILKA 5DGSF 5AFXA 3ASXA 3LVSA 4NFIF 4LA6A 5A0IA 4GP2A 3S9VA 3LMDA 1WMWA 5DJRF 3P8RA 5B00A 3WCBA 3DYGA 3ICKA 1KIYA 4UMJA 3WCGA 3Q2QA 2PS6A 2PS4A 5I1UA 3KRAB 1V4KA 5DHKA 4DZWA 3N1VF 3LZ9A 4NKFA 3LK5A 4KQSA 3WCFA 1V4JA 4RXEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2E94 A;  4LTV A;  4Q23 A;  3BNX A;  1N23 A;  5IMI A;  4KQU A;  2QIS A;  3WC9 A;  4E1E A;  4MC3 A;  3EGT A;  4QPF A;  2F9K F;  4H5D F;  4P0W A;  3VJB A;  4FJQ A;  4F62 A;  1V4E A;  2FOR A;  3IPI A;  3ZCD A;  4KKM A;  4LUU A;  3TFP A;  1UBX A;  5E8K A;  4KVY A;  1ZW5 A;  1HX9 A;  4KPJ A;  1DI1 A;  2H8O A;  3LEE A;  4KVD A;  5EAS A;  5DHI A;  1YYS A;  5DGN F;  5ERN A;  4E9Z A;  2E8U A;  4EA0 A;  5DW7 A;  2RAH A;  3WJO A;  5KSX F;  4MC0 A;  1N1B A;  4LFG A;  5ER8 A;  2Z7H A;  2Q80 A;  4LFV F;  4DEM F;  4FP4 A;  5HN8 A;  3PYB A;  1KIZ A;  1N24 A;  4GAX A;  2PS5 A;  3WEI A;  2O1O A;  1YYQ A;  3P41 A;  2E93 A;  4MC8 A;  5DIQ F;  4HD1 A;  1PS1 A;  5B0J A;  3CKE A;  2F8Z F;  3TFN A;  5IMP A;  3NRI A;  4DWG A;  1JFG A;  3LG5 A;  4JZB A;  1HXA A;  2Q9Z A;  3TC1 A;  2E8W A;  5HNA A;  3N0F A;  3WCI A;  4NUA A;  3N6K F;  2J5C A;  1RQI A;  4KQ5 A;  5AYP A;  3PYA A;  4XQT F;  3KRC A;  4LPH F;  3N5J F;  4JVJ F;  3WSA A;  4KFA A;  5JV1 F;  1EZF A;  3ZMC A;  3KB9 A;  4RXD A;  1HM7 A;  1V4H A;  3WEK A;  2Z4X A;  3N49 F;  5IKA A;  3MAV A;  3OYR A;  5JV0 F;  5H9D A;  3VJ9 A;  3KRO A;  4LZ0 A;  3KRF A;  4LOB A;  2F7M F;  4XQS F;  3WEJ A;  5B0K A;  2Z52 A;  2J1P A;  5IK0 A;  3AQC B;  4LZ3 A;  4H5C F;  4LPG F;  5DJP F;  5B0M A;  3LLW A;  4OKZ A;  2AZJ A;  4XQR F;  3P8L A;  5AEL A;  5JV2 F;  5B0L A;  3ACY A;  3SDU A;  3WCA A;  4N1Z F;  3V66 A;  4DWB A;  2E95 A;  3WJK A;  3CP6 A;  3M02 A;  5EAT A;  5B02 A;  3CC9 A;  4KVI A;  2ZCO A;  4N9U A;  2E8X A;  1JFA A;  3KRC B;  3NF2 A;  2E92 A;  5ILH A;  4NFJ F;  4JYX A;  2E91 A;  2ZEV A;  4KPD A;  5A0J A;  3LJI A;  2E4O A;  2PS7 A;  4WK5 A;  3KRO B;  1YQ7 A;  1WY0 A;  4GA3 A;  4KUX A;  4P0X A;  3WSB A;  3KRF B;  4NFK F;  3P5R A;  4RXA A;  3WEG A;  4DXJ A;  2ZEU A;  1VG7 A;  1YJ4 A;  3VJD A;  2F94 F;  3ACW A;  2F89 F;  5EAU A;  3WCH A;  2E90 A;  3ICM A;  4JZX A;  2EWG A;  3M00 A;  5DJV F;  3AQB B;  3N5H F;  2FTZ A;  4OMG A;  4F6X A;  2Z50 A;  2ZCS A;  3DYF A;  4OKM A;  2Z4Z A;  2Z7I A;  3DYH A;  1VG2 A;  3SDR A;  5IK9 A;  5JUZ F;  3M01 A;  1WL3 A;  5CG6 A;  1FPS A;  1UBV A;  4H5E F;  5IMN A;  2E8V A;  3N45 F;  3Q2Z A;  2OA6 A;  5ILD A;  3VJC A;  1N20 A;  5IKH A;  3SAE A;  5IM1 A;  1YV5 A;  3OAC A;  3N3D A;  4LXW A;  1VG4 A;  2ZY1 A;  1RQJ A;  1HXC A;  4E9U A;  3SDT A;  3LGZ B;  3Q1O A;  3ICZ A;  3WCC A;  5ERM A;  5DZ2 A;  3Q30 A;  5B01 A;  5ILY A;  3ICN A;  4F6V A;  4P0V A;  5B03 A;  4ZQ8 A;  4K10 A;  1N1Z A;  1WKZ A;  4NKE A;  4OGU A;  1N21 A;  3RBM A;  3VJA A;  2P1C A;  5ERO A;  5B0I A;  5IL8 A;  4LTZ A;  2Z78 A;  2ZCQ A;  1WL0 A;  3SDV A;  5E8H A;  3MZV A;  3N0G A;  2Z4Y A;  4LLS A;  3WE9 A;  3UCA A;  5C05 A;  1HM4 A;  3P5P A;  3NPK A;  2ONH A;  3RYE A;  5CG5 A;  4LIX A;  2Z4W A;  1V4I A;  3WJN A;  3ACX A;  1N22 A;  3RMG A;  4DHD A;  4GP1 A;  4LLT A;  2OGD A;  3N46 F;  2AEL A;  3KRP B;  3ZMB A;  1YYU A;  5IN8 A;  2OPM A;  5HN9 A;  3V1X A;  4KVW A;  3NPR A;  3KBK A;  4JXN A;  3WCD A;  3OAC B;  4RXC A;  2DH4 A;  4RNQ A;  3APZ A;  3WEF A;  3W7F A;  2ZCR A;  4LFE A;  2OPN A;  4PVX F;  3V1V A;  3PH7 A;  3LGK A;  3EFQ A;  1YHL A;  4JXY A;  2AZL A;  3QKC A;  3WCJ A;  4QXS F;  3RYW A;  2I19 A;  3OAB A;  3WCL A;  3IBA A;  2Z4V A;  1UBY A;  4DI5 A;  4LA5 A;  3B7L A;  4OMH A;  5IL3 A;  3ZL6 A;  3AQ0 A;  1UBW A;  1RTR A;  3WCE A;  2Q58 A;  3TS7 A;  2PS8 A;  3TFV A;  5IVG A;  4KK2 A;  4LZC A;  5A0K A;  2F92 F;  5DGM F;  3ZOU A;  4RYP A;  1VG3 A;  5ILI A;  3WEH A;  2E8T A;  2J1O A;  3LOM A;  1WL2 A;  2AET A;  3AE0 A;  3M9U A;  1YHM A;  5ILJ A;  1YHK A;  3BNY A;  3VJE A;  3QQV A;  2Q9Y A;  2AEK A;  4NG6 A;  3LDW A;  1DGP A;  1WL1 A;  3KRP A;  3WCM A;  4EA2 A;  3KRA A;  3ADZ A;  3ID0 A;  2VF6 A;  1YYR A;  5IK6 A;  3PKO A;  5JA0 F;  3EZ3 A;  2AZK A;  1HXG A;  3S4J A;  1VG6 A;  3G4F A;  3OAB B;  3SDQ A;  3VJ8 A;  4L2X F;  2F8C F;  3N1W F;  3LSN A;  5HN7 A;  5AHU B;  5E8L A;  3N3L F;  3PDE A;  1YYT A;  3M0G A;  4PVY F;  3G4D A;  4EA1 A;  4KWD A;  5ILZ A;  2ONG A;  5ILK A;  5DGS F;  5AFX A;  3ASX A;  3LVS A;  4NFI F;  4LA6 A;  5A0I A;  4GP2 A;  3S9V A;  3LMD A;  1WMW A;  5DJR F;  3P8R A;  5B00 A;  3WCB A;  3DYG A;  3ICK A;  1KIY A;  4UMJ A;  3WCG A;  3Q2Q A;  2PS6 A;  2PS4 A;  5I1U A;  3KRA B;  1V4K A;  5DHK A;  4DZW A;  3N1V F;  3LZ9 A;  4NKF A;  3LK5 A;  4KQS A;  3WCF A;  1V4J A;  4RXE A; 
#chains in the Genus database with same CATH topology
 2E94 A;  4LTV A;  4Q23 A;  3BNX A;  1N23 A;  5IMI A;  4KQU A;  2QIS A;  3WC9 A;  4E1E A;  4MC3 A;  3EGT A;  4QPF A;  2F9K F;  4H5D F;  4P0W A;  3VJB A;  4FJQ A;  4F62 A;  1V4E A;  2FOR A;  3IPI A;  3ZCD A;  4KKM A;  4LUU A;  3TFP A;  1UBX A;  5E8K A;  4KVY A;  1ZW5 A;  1HX9 A;  4KPJ A;  1DI1 A;  2H8O A;  3LEE A;  4KVD A;  5EAS A;  5DHI A;  1YYS A;  5DGN F;  5ERN A;  4E9Z A;  2E8U A;  4EA0 A;  5DW7 A;  2RAH A;  3WJO A;  5KSX F;  4MC0 A;  1N1B A;  4LFG A;  5ER8 A;  2Z7H A;  2Q80 A;  4LFV F;  4DEM F;  4FP4 A;  5HN8 A;  3PYB A;  1KIZ A;  1N24 A;  4GAX A;  2PS5 A;  3WEI A;  2O1O A;  1YYQ A;  3P41 A;  2E93 A;  4MC8 A;  5DIQ F;  4HD1 A;  1PS1 A;  5B0J A;  3CKE A;  2F8Z F;  3TFN A;  5IMP A;  3NRI A;  4DWG A;  1JFG A;  3LG5 A;  4JZB A;  1HXA A;  2Q9Z A;  3TC1 A;  2E8W A;  5HNA A;  3N0F A;  3WCI A;  4NUA A;  3N6K F;  2J5C A;  1RQI A;  4KQ5 A;  5AYP A;  3PYA A;  4XQT F;  3KRC A;  4LPH F;  3N5J F;  4JVJ F;  3WSA A;  4KFA A;  5JV1 F;  1EZF A;  3ZMC A;  3KB9 A;  4RXD A;  1HM7 A;  1V4H A;  3WEK A;  2Z4X A;  3N49 F;  5IKA A;  3MAV A;  3OYR A;  5JV0 F;  5H9D A;  3VJ9 A;  3KRO A;  4LZ0 A;  3KRF A;  4LOB A;  2F7M F;  4XQS F;  3WEJ A;  5B0K A;  2Z52 A;  2J1P A;  5IK0 A;  3AQC B;  4LZ3 A;  4H5C F;  4LPG F;  5DJP F;  5B0M A;  3LLW A;  4OKZ A;  2AZJ A;  4XQR F;  3P8L A;  5AEL A;  5JV2 F;  5B0L A;  3ACY A;  3SDU A;  3WCA A;  4N1Z F;  3V66 A;  4DWB A;  2E95 A;  3WJK A;  3CP6 A;  3M02 A;  5EAT A;  5B02 A;  3CC9 A;  4KVI A;  2ZCO A;  4N9U A;  2E8X A;  1JFA A;  3KRC B;  3NF2 A;  2E92 A;  5ILH A;  4NFJ F;  4JYX A;  2E91 A;  2ZEV A;  4KPD A;  5A0J A;  3LJI A;  2E4O A;  2PS7 A;  4WK5 A;  3KRO B;  1YQ7 A;  1WY0 A;  4GA3 A;  4KUX A;  4P0X A;  3WSB A;  3KRF B;  4NFK F;  3P5R A;  4RXA A;  3WEG A;  4DXJ A;  2ZEU A;  1VG7 A;  1YJ4 A;  3VJD A;  2F94 F;  3ACW A;  2F89 F;  5EAU A;  3WCH A;  2E90 A;  3ICM A;  4JZX A;  2EWG A;  3M00 A;  5DJV F;  3AQB B;  3N5H F;  2FTZ A;  4OMG A;  4F6X A;  2Z50 A;  2ZCS A;  3DYF A;  4OKM A;  2Z4Z A;  2Z7I A;  3DYH A;  1VG2 A;  3SDR A;  5IK9 A;  5JUZ F;  3M01 A;  1WL3 A;  5CG6 A;  1FPS A;  1UBV A;  4H5E F;  5IMN A;  2E8V A;  3N45 F;  3Q2Z A;  2OA6 A;  5ILD A;  3VJC A;  1N20 A;  5IKH A;  3SAE A;  5IM1 A;  1YV5 A;  3OAC A;  3N3D A;  4LXW A;  1VG4 A;  2ZY1 A;  1RQJ A;  1HXC A;  4E9U A;  3SDT A;  3LGZ B;  3Q1O A;  3ICZ A;  3WCC A;  5ERM A;  5DZ2 A;  3Q30 A;  5B01 A;  5ILY A;  3ICN A;  4F6V A;  4P0V A;  5B03 A;  4ZQ8 A;  4K10 A;  1N1Z A;  1WKZ A;  4NKE A;  4OGU A;  1N21 A;  3RBM A;  3VJA A;  2P1C A;  5ERO A;  5B0I A;  5IL8 A;  4LTZ A;  2Z78 A;  2ZCQ A;  1WL0 A;  3SDV A;  5E8H A;  3MZV A;  3N0G A;  2Z4Y A;  4LLS A;  3WE9 A;  3UCA A;  5C05 A;  1HM4 A;  3P5P A;  3NPK A;  2ONH A;  3RYE A;  5CG5 A;  4LIX A;  2Z4W A;  1V4I A;  3WJN A;  3ACX A;  1N22 A;  3RMG A;  4DHD A;  4GP1 A;  4LLT A;  2OGD A;  3N46 F;  2AEL A;  3KRP B;  3ZMB A;  1YYU A;  5IN8 A;  2OPM A;  5HN9 A;  3V1X A;  4KVW A;  3NPR A;  3KBK A;  4JXN A;  3WCD A;  3OAC B;  4RXC A;  2DH4 A;  4RNQ A;  3APZ A;  3WEF A;  3W7F A;  2ZCR A;  4LFE A;  2OPN A;  4PVX F;  3V1V A;  3PH7 A;  3LGK A;  3EFQ A;  1YHL A;  4JXY A;  2AZL A;  3QKC A;  3WCJ A;  4QXS F;  3RYW A;  2I19 A;  3OAB A;  3WCL A;  3IBA A;  2Z4V A;  1UBY A;  4DI5 A;  4LA5 A;  3B7L A;  4OMH A;  5IL3 A;  3ZL6 A;  3AQ0 A;  1UBW A;  1RTR A;  3WCE A;  2Q58 A;  3TS7 A;  2PS8 A;  3TFV A;  5IVG A;  4KK2 A;  4LZC A;  5A0K A;  2F92 F;  5DGM F;  3ZOU A;  4RYP A;  1VG3 A;  5ILI A;  3WEH A;  2E8T A;  2J1O A;  3LOM A;  1WL2 A;  2AET A;  3AE0 A;  3M9U A;  1YHM A;  5ILJ A;  1YHK A;  3BNY A;  3VJE A;  3QQV A;  2Q9Y A;  2AEK A;  4NG6 A;  3LDW A;  1DGP A;  1WL1 A;  3KRP A;  3WCM A;  4EA2 A;  3KRA A;  3ADZ A;  3ID0 A;  2VF6 A;  1YYR A;  5IK6 A;  3PKO A;  5JA0 F;  3EZ3 A;  2AZK A;  1HXG A;  3S4J A;  1VG6 A;  3G4F A;  3OAB B;  3SDQ A;  3VJ8 A;  4L2X F;  2F8C F;  3N1W F;  3LSN A;  5HN7 A;  5AHU B;  5E8L A;  3N3L F;  3PDE A;  1YYT A;  3M0G A;  4PVY F;  3G4D A;  4EA1 A;  4KWD A;  5ILZ A;  2ONG A;  5ILK A;  5DGS F;  5AFX A;  3ASX A;  3LVS A;  4NFI F;  4LA6 A;  5A0I A;  4GP2 A;  3S9V A;  3LMD A;  1WMW A;  5DJR F;  3P8R A;  5B00 A;  3WCB A;  3DYG A;  3ICK A;  1KIY A;  4UMJ A;  3WCG A;  3Q2Q A;  2PS6 A;  2PS4 A;  5I1U A;  3KRA B;  1V4K A;  5DHK A;  4DZW A;  3N1V F;  3LZ9 A;  4NKF A;  3LK5 A;  4KQS A;  3WCF A;  1V4J A;  4RXE A; 
#chains in the Genus database with same CATH homology
 2E94 A;  4LTV A;  4Q23 A;  3BNX A;  1N23 A;  5IMI A;  4KQU A;  2QIS A;  3WC9 A;  4E1E A;  4MC3 A;  3EGT A;  4QPF A;  2F9K F;  4H5D F;  4P0W A;  3VJB A;  4FJQ A;  4F62 A;  1V4E A;  2FOR A;  3IPI A;  3ZCD A;  4KKM A;  4LUU A;  3TFP A;  1UBX A;  5E8K A;  4KVY A;  1ZW5 A;  1HX9 A;  4KPJ A;  1DI1 A;  2H8O A;  3LEE A;  4KVD A;  5EAS A;  5DHI A;  1YYS A;  5DGN F;  5ERN A;  4E9Z A;  2E8U A;  4EA0 A;  5DW7 A;  2RAH A;  3WJO A;  5KSX F;  4MC0 A;  1N1B A;  4LFG A;  5ER8 A;  2Z7H A;  2Q80 A;  4LFV F;  4DEM F;  4FP4 A;  5HN8 A;  3PYB A;  1KIZ A;  1N24 A;  4GAX A;  2PS5 A;  3WEI A;  2O1O A;  1YYQ A;  3P41 A;  2E93 A;  4MC8 A;  5DIQ F;  4HD1 A;  1PS1 A;  5B0J A;  3CKE A;  2F8Z F;  3TFN A;  5IMP A;  3NRI A;  4DWG A;  1JFG A;  3LG5 A;  4JZB A;  1HXA A;  2Q9Z A;  3TC1 A;  2E8W A;  5HNA A;  3N0F A;  3WCI A;  4NUA A;  3N6K F;  2J5C A;  1RQI A;  4KQ5 A;  5AYP A;  3PYA A;  4XQT F;  3KRC A;  4LPH F;  3N5J F;  4JVJ F;  3WSA A;  4KFA A;  5JV1 F;  1EZF A;  3ZMC A;  3KB9 A;  4RXD A;  1HM7 A;  1V4H A;  3WEK A;  2Z4X A;  3N49 F;  5IKA A;  3MAV A;  3OYR A;  5JV0 F;  5H9D A;  3VJ9 A;  3KRO A;  4LZ0 A;  3KRF A;  4LOB A;  2F7M F;  4XQS F;  3WEJ A;  5B0K A;  2Z52 A;  2J1P A;  5IK0 A;  3AQC B;  4LZ3 A;  4H5C F;  4LPG F;  5DJP F;  5B0M A;  3LLW A;  4OKZ A;  2AZJ A;  4XQR F;  3P8L A;  5AEL A;  5JV2 F;  5B0L A;  3ACY A;  3SDU A;  3WCA A;  4N1Z F;  3V66 A;  4DWB A;  2E95 A;  3WJK A;  3CP6 A;  3M02 A;  5EAT A;  5B02 A;  3CC9 A;  4KVI A;  2ZCO A;  4N9U A;  2E8X A;  1JFA A;  3KRC B;  3NF2 A;  2E92 A;  5ILH A;  4NFJ F;  4JYX A;  2E91 A;  2ZEV A;  4KPD A;  5A0J A;  3LJI A;  2E4O A;  2PS7 A;  4WK5 A;  3KRO B;  1YQ7 A;  1WY0 A;  4GA3 A;  4KUX A;  4P0X A;  3WSB A;  3KRF B;  4NFK F;  3P5R A;  4RXA A;  3WEG A;  4DXJ A;  2ZEU A;  1VG7 A;  1YJ4 A;  3VJD A;  2F94 F;  3ACW A;  2F89 F;  5EAU A;  3WCH A;  2E90 A;  3ICM A;  4JZX A;  2EWG A;  3M00 A;  5DJV F;  3AQB B;  3N5H F;  2FTZ A;  4OMG A;  4F6X A;  2Z50 A;  2ZCS A;  3DYF A;  4OKM A;  2Z4Z A;  2Z7I A;  3DYH A;  1VG2 A;  3SDR A;  5IK9 A;  5JUZ F;  3M01 A;  1WL3 A;  5CG6 A;  1FPS A;  1UBV A;  4H5E F;  5IMN A;  2E8V A;  3N45 F;  3Q2Z A;  2OA6 A;  5ILD A;  3VJC A;  1N20 A;  5IKH A;  3SAE A;  5IM1 A;  1YV5 A;  3OAC A;  3N3D A;  4LXW A;  1VG4 A;  2ZY1 A;  1RQJ A;  1HXC A;  4E9U A;  3SDT A;  3LGZ B;  3Q1O A;  3ICZ A;  3WCC A;  5ERM A;  5DZ2 A;  3Q30 A;  5B01 A;  5ILY A;  3ICN A;  4F6V A;  4P0V A;  5B03 A;  4ZQ8 A;  4K10 A;  1N1Z A;  1WKZ A;  4NKE A;  4OGU A;  1N21 A;  3RBM A;  3VJA A;  2P1C A;  5ERO A;  5B0I A;  5IL8 A;  4LTZ A;  2Z78 A;  2ZCQ A;  1WL0 A;  3SDV A;  5E8H A;  3MZV A;  3N0G A;  2Z4Y A;  4LLS A;  3WE9 A;  3UCA A;  5C05 A;  1HM4 A;  3P5P A;  3NPK A;  2ONH A;  3RYE A;  5CG5 A;  4LIX A;  2Z4W A;  1V4I A;  3WJN A;  3ACX A;  1N22 A;  3RMG A;  4DHD A;  4GP1 A;  4LLT A;  2OGD A;  3N46 F;  2AEL A;  3KRP B;  3ZMB A;  1YYU A;  5IN8 A;  2OPM A;  5HN9 A;  3V1X A;  4KVW A;  3NPR A;  3KBK A;  4JXN A;  3WCD A;  3OAC B;  4RXC A;  2DH4 A;  4RNQ A;  3APZ A;  3WEF A;  3W7F A;  2ZCR A;  4LFE A;  2OPN A;  4PVX F;  3V1V A;  3PH7 A;  3LGK A;  3EFQ A;  1YHL A;  4JXY A;  2AZL A;  3QKC A;  3WCJ A;  4QXS F;  3RYW A;  2I19 A;  3OAB A;  3WCL A;  3IBA A;  2Z4V A;  1UBY A;  4DI5 A;  4LA5 A;  3B7L A;  4OMH A;  5IL3 A;  3ZL6 A;  3AQ0 A;  1UBW A;  1RTR A;  3WCE A;  2Q58 A;  3TS7 A;  2PS8 A;  3TFV A;  5IVG A;  4KK2 A;  4LZC A;  5A0K A;  2F92 F;  5DGM F;  3ZOU A;  4RYP A;  1VG3 A;  5ILI A;  3WEH A;  2E8T A;  2J1O A;  3LOM A;  1WL2 A;  2AET A;  3AE0 A;  3M9U A;  1YHM A;  5ILJ A;  1YHK A;  3BNY A;  3VJE A;  3QQV A;  2Q9Y A;  2AEK A;  4NG6 A;  3LDW A;  1DGP A;  1WL1 A;  3KRP A;  3WCM A;  4EA2 A;  3KRA A;  3ADZ A;  3ID0 A;  2VF6 A;  1YYR A;  5IK6 A;  3PKO A;  5JA0 F;  3EZ3 A;  2AZK A;  1HXG A;  3S4J A;  1VG6 A;  3G4F A;  3OAB B;  3SDQ A;  3VJ8 A;  4L2X F;  2F8C F;  3N1W F;  3LSN A;  5HN7 A;  5AHU B;  5E8L A;  3N3L F;  3PDE A;  1YYT A;  3M0G A;  4PVY F;  3G4D A;  4EA1 A;  4KWD A;  5ILZ A;  2ONG A;  5ILK A;  5DGS F;  5AFX A;  3ASX A;  3LVS A;  4NFI F;  4LA6 A;  5A0I A;  4GP2 A;  3S9V A;  3LMD A;  1WMW A;  5DJR F;  3P8R A;  5B00 A;  3WCB A;  3DYG A;  3ICK A;  1KIY A;  4UMJ A;  3WCG A;  3Q2Q A;  2PS6 A;  2PS4 A;  5I1U A;  3KRA B;  1V4K A;  5DHK A;  4DZW A;  3N1V F;  3LZ9 A;  4NKF A;  3LK5 A;  4KQS A;  3WCF A;  1V4J A;  4RXE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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