4QPFA

New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption
Total Genus 133
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
133
sequence length
342
structure length
337
Chain Sequence
VYAQEKQDFVQHFSQIVRVLTEPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption
rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Farnesyl pyrophosphate synthase
total genus 133
structure length 337
sequence length 342
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2014-06-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4qpfA00
2F92F 3WCLA 3G4FA 4F6XA 5ILKA 1WMWA 3WCDA 3SDUA 4LOBA 5B0IA 4H5CF 1V4KA 1ZW5A 3M00A 1RTRA 1YYTA 3DYHA 3WCHA 3KRFA 5IL3A 2Z4WA 4RNQA 5B02A 2ZEUA 4QPFA 3N1WF 3KRFB 2AETA 4GAXA 3WCEA 2E4OA 4LZCA 4P0VA 4P0XA 5IK9A 2F7MF 5DW7A 4JVJF 3EFQA 3ID0A 4LFEA 4RYPA 3WEFA 5ILDA 5B00A 2O1OA 4DHDA 3S4JA 2Q58A 4P0WA 2E8UA 1UBXA 2Q9YA 1YHMA 3M01A 3CC9A 4N1ZF 3M9UA 2PS4A 3VJ8A 2ZCRA 5ILYA 2J5CA 5E8LA 4KVWA 5B0LA 2EWGA 5DJPF 5IK0A 2Z50A 3KROA 1YHLA 4NFJF 3VJCA 2DH4A 3KROB 1V4HA 2AZJA 2E94A 3LG5A 2Z52A 3PDEA 1UBYA 3RMGA 5B0KA 5IMPA 4E9ZA 4KQSA 3M02A 3N6KF 3VJDA 3ICZA 1WL3A 3WEIA 3KRPB 4JYXA 5KSXF 3ACWA 5HN8A 3WJKA 4GP2A 3Q1OA 4JZXA 5AELA 1JFGA 3RYEA 1VG3A 1YQ7A 3VJEA 3N0FA 4Q23A 3P41A 5HN9A 5AHUB 1N1ZA 1KIYA 5JV1F 4KVYA 4F6VA 1HM7A 3OACA 3TFVA 3N45F 4XQRF 4KVDA 3WCGA 4DEMF 5DJVF 3WEJA 5E8KA 4DI5A 4OMGA 3AE0A 1V4IA 3WCIA 3P5PA 5HN7A 3ICNA 3TS7A 1WL0A 4LTVA 2ZEVA 2OGDA 3N0GA 3NRIA 3LOMA 3N46F 5EASA 5EROA 5IMIA 2Q9ZA 4L2XF 3B7LA 3P8RA 4DWBA 1VG7A 3LGZB 3ICKA 2AELA 4PVXF 1RQJA 5B03A 2E8TA 5IN8A 3SDVA 4E9UA 5IK6A 4RXAA 3WCBA 4MC8A 3TFPA 4RXEA 3ADZA 2Z78A 3WJNA 3BNYA 2FTZA 3IBAA 3WEGA 2J1PA 4JXYA 1V4JA 5ILZA 5IMNA 3AQ0A 2ZCSA 1PS1A 2F8ZF 1WKZA 2ZY1A 4LZ0A 2F8CF 4KK2A 3WSAA 2Z7IA 3S9VA 2VF6A 4MC0A 3VJAA 3KBKA 3N1VF 5DGNF 5IM1A 3BNXA 2E8VA 3VJ9A 5ERMA 5ER8A 4OKZA 5DGSF 4FJQA 3ZMBA 3ICMA 2E90A 4FP4A 5DHKA 4ZQ8A 5DZ2A 5DJRF 4JZBA 1WL1A 2P1CA 2OPMA 4EA1A 4NUAA 1N24A 3Q30A 5EATA 4LFVF 3V66A 3CP6A 1YV5A 4NKFA 2F89F 1HM4A 3KRPA 3WEHA 4DXJA 4LUUA 2AZLA 5IL8A 3SAEA 3WCJA 2E8XA 3LGKA 3SDRA 4LXWA 5JV2F 3LDWA 2E92A 3KB9A 5JUZF 5DHIA 2ZCOA 1HXAA 4KVIA 4QXSF 2I19A 5DIQF 2AZKA 3P8LA 4GA3A 3UCAA 4E1EA 5HNAA 4KPJA 4LFGA 4KWDA 1YHKA 2Z4YA 3SDTA 3QQVA 1UBVA 1JFAA 1VG4A 2FORA 3MAVA 4KFAA 3ZOUA 1V4EA 2PS8A 4KKMA 2ONHA 4LPHF 4DWGA 4NKEA 1KIZA 3PH7A 3V1XA 2E91A 3ZCDA 1UBWA 3IPIA 3WC9A 4EA0A 5IVGA 2Q80A 3PYAA 3LVSA 4NG6A 2PS6A 1YJ4A 5CG5A 3TFNA 2ONGA 4MC3A 5A0KA 2Z7HA 3RYWA 4LA5A 4UMJA 3LZ9A 1DGPA 4LLTA 5ILHA 4KQ5A 2PS7A 5JA0F 3LLWA 3WCCA 3W7FA 3N3LF 1HXGA 3ACXA 5B0JA 1N23A 5IKAA 2E95A 2F94F 3N5JF 4RXCA 4LLSA 1WY0A 2RAHA 3Q2ZA 3LEEA 3AQCB 3PYBA 1YYRA 3WEKA 2ZCQA 3M0GA 4KQUA 1WL2A 3LK5A 2E93A 3NPRA 3G4DA 4WK5A 2F9KF 4XQTF 4KPDA 5DGMF 4DZWA 1YYUA 2QISA 1YYSA 2Z4XA 5B0MA 3WJOA 3RBMA 4F62A 1FPSA 3ASXA 3SDQA 4EA2A 2OPNA 3DYGA 4LA6A 5I1UA 2J1OA 3APZA 5AYPA 4NFIF 1N20A 5EAUA 3KRCA 4KUXA 4PVYF 2Z4VA 3Q2QA 3WSBA 3KRCB 3PKOA 4OGUA 4LZ3A 3EZ3A 2E8WA 4LTZA 3CKEA 3LMDA 3KRAA 1HXCA 3ACYA 1N21A 4NFKF 2AEKA 3KRAB 3ZL6A 3QKCA 3WCAA 5CG6A 5AFXA 1RQIA 5H9DA 5JV0F 3NF2A 5ILJA 3AQBB 3EGTA 3LSNA 4N9UA 3LJIA 3ZMCA 4GP1A 3NPKA 3V1VA 4LPGF 1EZFA 3MZVA 3OYRA 3WCFA 4LIXA 5IKHA 2PS5A 3OABA 4OMHA 1N22A 4H5DF 5B01A 3OABB 3DYFA 4RXDA 2H8OA 5ERNA 1N1BA 5C05A 5ILIA 4JXNA 4OKMA 2OA6A 1DI1A 3TC1A 1YYQA 3WE9A 5A0JA 4XQSF 3WCMA 1VG6A 3OACB 5E8HA 3N3DA 3N5HF 3VJBA 1HX9A 4H5EF 4HD1A 3N49F 3P5RA 5A0IA 4K10A 2Z4ZA 1VG2A
chains in the Genus database with same CATH superfamily
2F92F 3WCLA 3G4FA 4F6XA 5ILKA 1WMWA 3WCDA 3SDUA 4LOBA 5B0IA 4H5CF 1V4KA 1ZW5A 3M00A 1RTRA 1YYTA 3DYHA 3WCHA 3KRFA 5IL3A 2Z4WA 4RNQA 5B02A 2ZEUA 4QPFA 3N1WF 3KRFB 2AETA 4GAXA 3WCEA 2E4OA 4LZCA 4P0VA 4P0XA 5IK9A 2F7MF 5DW7A 4JVJF 3EFQA 3ID0A 4LFEA 4RYPA 3WEFA 5ILDA 5B00A 2O1OA 4DHDA 3S4JA 2Q58A 4P0WA 2E8UA 1UBXA 2Q9YA 1YHMA 3M01A 3CC9A 4N1ZF 3M9UA 2PS4A 3VJ8A 2ZCRA 5ILYA 2J5CA 5E8LA 4KVWA 5B0LA 2EWGA 5DJPF 5IK0A 2Z50A 3KROA 1YHLA 4NFJF 3VJCA 2DH4A 3KROB 1V4HA 2AZJA 2E94A 3LG5A 2Z52A 3PDEA 1UBYA 3RMGA 5B0KA 5IMPA 4E9ZA 4KQSA 3M02A 3N6KF 3VJDA 3ICZA 1WL3A 3WEIA 3KRPB 4JYXA 5KSXF 3ACWA 5HN8A 3WJKA 4GP2A 3Q1OA 4JZXA 5AELA 1JFGA 3RYEA 1VG3A 1YQ7A 3VJEA 3N0FA 4Q23A 3P41A 5HN9A 5AHUB 1N1ZA 1KIYA 5JV1F 4KVYA 4F6VA 1HM7A 3OACA 3TFVA 3N45F 4XQRF 4KVDA 3WCGA 4DEMF 5DJVF 3WEJA 5E8KA 4DI5A 4OMGA 3AE0A 1V4IA 3WCIA 3P5PA 5HN7A 3ICNA 3TS7A 1WL0A 4LTVA 2ZEVA 2OGDA 3N0GA 3NRIA 3LOMA 3N46F 5EASA 5EROA 5IMIA 2Q9ZA 4L2XF 3B7LA 3P8RA 4DWBA 1VG7A 3LGZB 3ICKA 2AELA 4PVXF 1RQJA 5B03A 2E8TA 5IN8A 3SDVA 4E9UA 5IK6A 4RXAA 3WCBA 4MC8A 3TFPA 4RXEA 3ADZA 2Z78A 3WJNA 3BNYA 2FTZA 3IBAA 3WEGA 2J1PA 4JXYA 1V4JA 5ILZA 5IMNA 3AQ0A 2ZCSA 1PS1A 2F8ZF 1WKZA 2ZY1A 4LZ0A 2F8CF 4KK2A 3WSAA 2Z7IA 3S9VA 2VF6A 4MC0A 3VJAA 3KBKA 3N1VF 5DGNF 5IM1A 3BNXA 2E8VA 3VJ9A 5ERMA 5ER8A 4OKZA 5DGSF 4FJQA 3ZMBA 3ICMA 2E90A 4FP4A 5DHKA 4ZQ8A 5DZ2A 5DJRF 4JZBA 1WL1A 2P1CA 2OPMA 4EA1A 4NUAA 1N24A 3Q30A 5EATA 4LFVF 3V66A 3CP6A 1YV5A 4NKFA 2F89F 1HM4A 3KRPA 3WEHA 4DXJA 4LUUA 2AZLA 5IL8A 3SAEA 3WCJA 2E8XA 3LGKA 3SDRA 4LXWA 5JV2F 3LDWA 2E92A 3KB9A 5JUZF 5DHIA 2ZCOA 1HXAA 4KVIA 4QXSF 2I19A 5DIQF 2AZKA 3P8LA 4GA3A 3UCAA 4E1EA 5HNAA 4KPJA 4LFGA 4KWDA 1YHKA 2Z4YA 3SDTA 3QQVA 1UBVA 1JFAA 1VG4A 2FORA 3MAVA 4KFAA 3ZOUA 1V4EA 2PS8A 4KKMA 2ONHA 4LPHF 4DWGA 4NKEA 1KIZA 3PH7A 3V1XA 2E91A 3ZCDA 1UBWA 3IPIA 3WC9A 4EA0A 5IVGA 2Q80A 3PYAA 3LVSA 4NG6A 2PS6A 1YJ4A 5CG5A 3TFNA 2ONGA 4MC3A 5A0KA 2Z7HA 3RYWA 4LA5A 4UMJA 3LZ9A 1DGPA 4LLTA 5ILHA 4KQ5A 2PS7A 5JA0F 3LLWA 3WCCA 3W7FA 3N3LF 1HXGA 3ACXA 5B0JA 1N23A 5IKAA 2E95A 2F94F 3N5JF 4RXCA 4LLSA 1WY0A 2RAHA 3Q2ZA 3LEEA 3AQCB 3PYBA 1YYRA 3WEKA 2ZCQA 3M0GA 4KQUA 1WL2A 3LK5A 2E93A 3NPRA 3G4DA 4WK5A 2F9KF 4XQTF 4KPDA 5DGMF 4DZWA 1YYUA 2QISA 1YYSA 2Z4XA 5B0MA 3WJOA 3RBMA 4F62A 1FPSA 3ASXA 3SDQA 4EA2A 2OPNA 3DYGA 4LA6A 5I1UA 2J1OA 3APZA 5AYPA 4NFIF 1N20A 5EAUA 3KRCA 4KUXA 4PVYF 2Z4VA 3Q2QA 3WSBA 3KRCB 3PKOA 4OGUA 4LZ3A 3EZ3A 2E8WA 4LTZA 3CKEA 3LMDA 3KRAA 1HXCA 3ACYA 1N21A 4NFKF 2AEKA 3KRAB 3ZL6A 3QKCA 3WCAA 5CG6A 5AFXA 1RQIA 5H9DA 5JV0F 3NF2A 5ILJA 3AQBB 3EGTA 3LSNA 4N9UA 3LJIA 3ZMCA 4GP1A 3NPKA 3V1VA 4LPGF 1EZFA 3MZVA 3OYRA 3WCFA 4LIXA 5IKHA 2PS5A 3OABA 4OMHA 1N22A 4H5DF 5B01A 3OABB 3DYFA 4RXDA 2H8OA 5ERNA 1N1BA 5C05A 5ILIA 4JXNA 4OKMA 2OA6A 1DI1A 3TC1A 1YYQA 3WE9A 5A0JA 4XQSF 3WCMA 1VG6A 3OACB 5E8HA 3N3DA 3N5HF 3VJBA 1HX9A 4H5EF 4HD1A 3N49F 3P5RA 5A0IA 4K10A 2Z4ZA 1VG2A
chains in the Genus database with same CATH topology
2F92F 3WCLA 3G4FA 4F6XA 5ILKA 1WMWA 3WCDA 3SDUA 4LOBA 5B0IA 4H5CF 1V4KA 1ZW5A 3M00A 1RTRA 1YYTA 3DYHA 3WCHA 3KRFA 5IL3A 2Z4WA 4RNQA 5B02A 2ZEUA 4QPFA 3N1WF 3KRFB 2AETA 4GAXA 3WCEA 2E4OA 4LZCA 4P0VA 4P0XA 5IK9A 2F7MF 5DW7A 4JVJF 3EFQA 3ID0A 4LFEA 4RYPA 3WEFA 5ILDA 5B00A 2O1OA 4DHDA 3S4JA 2Q58A 4P0WA 2E8UA 1UBXA 2Q9YA 1YHMA 3M01A 3CC9A 4N1ZF 3M9UA 2PS4A 3VJ8A 2ZCRA 5ILYA 2J5CA 5E8LA 4KVWA 5B0LA 2EWGA 5DJPF 5IK0A 2Z50A 3KROA 1YHLA 4NFJF 3VJCA 2DH4A 3KROB 1V4HA 2AZJA 2E94A 3LG5A 2Z52A 3PDEA 1UBYA 3RMGA 5B0KA 5IMPA 4E9ZA 4KQSA 3M02A 3N6KF 3VJDA 3ICZA 1WL3A 3WEIA 3KRPB 4JYXA 5KSXF 3ACWA 5HN8A 3WJKA 4GP2A 3Q1OA 4JZXA 5AELA 1JFGA 3RYEA 1VG3A 1YQ7A 3VJEA 3N0FA 4Q23A 3P41A 5HN9A 5AHUB 1N1ZA 1KIYA 5JV1F 4KVYA 4F6VA 1HM7A 3OACA 3TFVA 3N45F 4XQRF 4KVDA 3WCGA 4DEMF 5DJVF 3WEJA 5E8KA 4DI5A 4OMGA 3AE0A 1V4IA 3WCIA 3P5PA 5HN7A 3ICNA 3TS7A 1WL0A 4LTVA 2ZEVA 2OGDA 3N0GA 3NRIA 3LOMA 3N46F 5EASA 5EROA 5IMIA 2Q9ZA 4L2XF 3B7LA 3P8RA 4DWBA 1VG7A 3LGZB 3ICKA 2AELA 4PVXF 1RQJA 5B03A 2E8TA 5IN8A 3SDVA 4E9UA 5IK6A 4RXAA 3WCBA 4MC8A 3TFPA 4RXEA 3ADZA 2Z78A 3WJNA 3BNYA 2FTZA 3IBAA 3WEGA 2J1PA 4JXYA 1V4JA 5ILZA 5IMNA 3AQ0A 2ZCSA 1PS1A 2F8ZF 1WKZA 2ZY1A 4LZ0A 2F8CF 4KK2A 3WSAA 2Z7IA 3S9VA 2VF6A 4MC0A 3VJAA 3KBKA 3N1VF 5DGNF 5IM1A 3BNXA 2E8VA 3VJ9A 5ERMA 5ER8A 4OKZA 5DGSF 4FJQA 3ZMBA 3ICMA 2E90A 4FP4A 5DHKA 4ZQ8A 5DZ2A 5DJRF 4JZBA 1WL1A 2P1CA 2OPMA 4EA1A 4NUAA 1N24A 3Q30A 5EATA 4LFVF 3V66A 3CP6A 1YV5A 4NKFA 2F89F 1HM4A 3KRPA 3WEHA 4DXJA 4LUUA 2AZLA 5IL8A 3SAEA 3WCJA 2E8XA 3LGKA 3SDRA 4LXWA 5JV2F 3LDWA 2E92A 3KB9A 5JUZF 5DHIA 2ZCOA 1HXAA 4KVIA 4QXSF 2I19A 5DIQF 2AZKA 3P8LA 4GA3A 3UCAA 4E1EA 5HNAA 4KPJA 4LFGA 4KWDA 1YHKA 2Z4YA 3SDTA 3QQVA 1UBVA 1JFAA 1VG4A 2FORA 3MAVA 4KFAA 3ZOUA 1V4EA 2PS8A 4KKMA 2ONHA 4LPHF 4DWGA 4NKEA 1KIZA 3PH7A 3V1XA 2E91A 3ZCDA 1UBWA 3IPIA 3WC9A 4EA0A 5IVGA 2Q80A 3PYAA 3LVSA 4NG6A 2PS6A 1YJ4A 5CG5A 3TFNA 2ONGA 4MC3A 5A0KA 2Z7HA 3RYWA 4LA5A 4UMJA 3LZ9A 1DGPA 4LLTA 5ILHA 4KQ5A 2PS7A 5JA0F 3LLWA 3WCCA 3W7FA 3N3LF 1HXGA 3ACXA 5B0JA 1N23A 5IKAA 2E95A 2F94F 3N5JF 4RXCA 4LLSA 1WY0A 2RAHA 3Q2ZA 3LEEA 3AQCB 3PYBA 1YYRA 3WEKA 2ZCQA 3M0GA 4KQUA 1WL2A 3LK5A 2E93A 3NPRA 3G4DA 4WK5A 2F9KF 4XQTF 4KPDA 5DGMF 4DZWA 1YYUA 2QISA 1YYSA 2Z4XA 5B0MA 3WJOA 3RBMA 4F62A 1FPSA 3ASXA 3SDQA 4EA2A 2OPNA 3DYGA 4LA6A 5I1UA 2J1OA 3APZA 5AYPA 4NFIF 1N20A 5EAUA 3KRCA 4KUXA 4PVYF 2Z4VA 3Q2QA 3WSBA 3KRCB 3PKOA 4OGUA 4LZ3A 3EZ3A 2E8WA 4LTZA 3CKEA 3LMDA 3KRAA 1HXCA 3ACYA 1N21A 4NFKF 2AEKA 3KRAB 3ZL6A 3QKCA 3WCAA 5CG6A 5AFXA 1RQIA 5H9DA 5JV0F 3NF2A 5ILJA 3AQBB 3EGTA 3LSNA 4N9UA 3LJIA 3ZMCA 4GP1A 3NPKA 3V1VA 4LPGF 1EZFA 3MZVA 3OYRA 3WCFA 4LIXA 5IKHA 2PS5A 3OABA 4OMHA 1N22A 4H5DF 5B01A 3OABB 3DYFA 4RXDA 2H8OA 5ERNA 1N1BA 5C05A 5ILIA 4JXNA 4OKMA 2OA6A 1DI1A 3TC1A 1YYQA 3WE9A 5A0JA 4XQSF 3WCMA 1VG6A 3OACB 5E8HA 3N3DA 3N5HF 3VJBA 1HX9A 4H5EF 4HD1A 3N49F 3P5RA 5A0IA 4K10A 2Z4ZA 1VG2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2F92 F;  3WCL A;  3G4F A;  4F6X A;  5ILK A;  1WMW A;  3WCD A;  3SDU A;  4LOB A;  5B0I A;  4H5C F;  1V4K A;  1ZW5 A;  3M00 A;  1RTR A;  1YYT A;  3DYH A;  3WCH A;  3KRF A;  5IL3 A;  2Z4W A;  4RNQ A;  5B02 A;  2ZEU A;  4QPF A;  3N1W F;  3KRF B;  2AET A;  4GAX A;  3WCE A;  2E4O A;  4LZC A;  4P0V A;  4P0X A;  5IK9 A;  2F7M F;  5DW7 A;  4JVJ F;  3EFQ A;  3ID0 A;  4LFE A;  4RYP A;  3WEF A;  5ILD A;  5B00 A;  2O1O A;  4DHD A;  3S4J A;  2Q58 A;  4P0W A;  2E8U A;  1UBX A;  2Q9Y A;  1YHM A;  3M01 A;  3CC9 A;  4N1Z F;  3M9U A;  2PS4 A;  3VJ8 A;  2ZCR A;  5ILY A;  2J5C A;  5E8L A;  4KVW A;  5B0L A;  2EWG A;  5DJP F;  5IK0 A;  2Z50 A;  3KRO A;  1YHL A;  4NFJ F;  3VJC A;  2DH4 A;  3KRO B;  1V4H A;  2AZJ A;  2E94 A;  3LG5 A;  2Z52 A;  3PDE A;  1UBY A;  3RMG A;  5B0K A;  5IMP A;  4E9Z A;  4KQS A;  3M02 A;  3N6K F;  3VJD A;  3ICZ A;  1WL3 A;  3WEI A;  3KRP B;  4JYX A;  5KSX F;  3ACW A;  5HN8 A;  3WJK A;  4GP2 A;  3Q1O A;  4JZX A;  5AEL A;  1JFG A;  3RYE A;  1VG3 A;  1YQ7 A;  3VJE A;  3N0F A;  4Q23 A;  3P41 A;  5HN9 A;  5AHU B;  1N1Z A;  1KIY A;  5JV1 F;  4KVY A;  4F6V A;  1HM7 A;  3OAC A;  3TFV A;  3N45 F;  4XQR F;  4KVD A;  3WCG A;  4DEM F;  5DJV F;  3WEJ A;  5E8K A;  4DI5 A;  4OMG A;  3AE0 A;  1V4I A;  3WCI A;  3P5P A;  5HN7 A;  3ICN A;  3TS7 A;  1WL0 A;  4LTV A;  2ZEV A;  2OGD A;  3N0G A;  3NRI A;  3LOM A;  3N46 F;  5EAS A;  5ERO A;  5IMI A;  2Q9Z A;  4L2X F;  3B7L A;  3P8R A;  4DWB A;  1VG7 A;  3LGZ B;  3ICK A;  2AEL A;  4PVX F;  1RQJ A;  5B03 A;  2E8T A;  5IN8 A;  3SDV A;  4E9U A;  5IK6 A;  4RXA A;  3WCB A;  4MC8 A;  3TFP A;  4RXE A;  3ADZ A;  2Z78 A;  3WJN A;  3BNY A;  2FTZ A;  3IBA A;  3WEG A;  2J1P A;  4JXY A;  1V4J A;  5ILZ A;  5IMN A;  3AQ0 A;  2ZCS A;  1PS1 A;  2F8Z F;  1WKZ A;  2ZY1 A;  4LZ0 A;  2F8C F;  4KK2 A;  3WSA A;  2Z7I A;  3S9V A;  2VF6 A;  4MC0 A;  3VJA A;  3KBK A;  3N1V F;  5DGN F;  5IM1 A;  3BNX A;  2E8V A;  3VJ9 A;  5ERM A;  5ER8 A;  4OKZ A;  5DGS F;  4FJQ A;  3ZMB A;  3ICM A;  2E90 A;  4FP4 A;  5DHK A;  4ZQ8 A;  5DZ2 A;  5DJR F;  4JZB A;  1WL1 A;  2P1C A;  2OPM A;  4EA1 A;  4NUA A;  1N24 A;  3Q30 A;  5EAT A;  4LFV F;  3V66 A;  3CP6 A;  1YV5 A;  4NKF A;  2F89 F;  1HM4 A;  3KRP A;  3WEH A;  4DXJ A;  4LUU A;  2AZL A;  5IL8 A;  3SAE A;  3WCJ A;  2E8X A;  3LGK A;  3SDR A;  4LXW A;  5JV2 F;  3LDW A;  2E92 A;  3KB9 A;  5JUZ F;  5DHI A;  2ZCO A;  1HXA A;  4KVI A;  4QXS F;  2I19 A;  5DIQ F;  2AZK A;  3P8L A;  4GA3 A;  3UCA A;  4E1E A;  5HNA A;  4KPJ A;  4LFG A;  4KWD A;  1YHK A;  2Z4Y A;  3SDT A;  3QQV A;  1UBV A;  1JFA A;  1VG4 A;  2FOR A;  3MAV A;  4KFA A;  3ZOU A;  1V4E A;  2PS8 A;  4KKM A;  2ONH A;  4LPH F;  4DWG A;  4NKE A;  1KIZ A;  3PH7 A;  3V1X A;  2E91 A;  3ZCD A;  1UBW A;  3IPI A;  3WC9 A;  4EA0 A;  5IVG A;  2Q80 A;  3PYA A;  3LVS A;  4NG6 A;  2PS6 A;  1YJ4 A;  5CG5 A;  3TFN A;  2ONG A;  4MC3 A;  5A0K A;  2Z7H A;  3RYW A;  4LA5 A;  4UMJ A;  3LZ9 A;  1DGP A;  4LLT A;  5ILH A;  4KQ5 A;  2PS7 A;  5JA0 F;  3LLW A;  3WCC A;  3W7F A;  3N3L F;  1HXG A;  3ACX A;  5B0J A;  1N23 A;  5IKA A;  2E95 A;  2F94 F;  3N5J F;  4RXC A;  4LLS A;  1WY0 A;  2RAH A;  3Q2Z A;  3LEE A;  3AQC B;  3PYB A;  1YYR A;  3WEK A;  2ZCQ A;  3M0G A;  4KQU A;  1WL2 A;  3LK5 A;  2E93 A;  3NPR A;  3G4D A;  4WK5 A;  2F9K F;  4XQT F;  4KPD A;  5DGM F;  4DZW A;  1YYU A;  2QIS A;  1YYS A;  2Z4X A;  5B0M A;  3WJO A;  3RBM A;  4F62 A;  1FPS A;  3ASX A;  3SDQ A;  4EA2 A;  2OPN A;  3DYG A;  4LA6 A;  5I1U A;  2J1O A;  3APZ A;  5AYP A;  4NFI F;  1N20 A;  5EAU A;  3KRC A;  4KUX A;  4PVY F;  2Z4V A;  3Q2Q A;  3WSB A;  3KRC B;  3PKO A;  4OGU A;  4LZ3 A;  3EZ3 A;  2E8W A;  4LTZ A;  3CKE A;  3LMD A;  3KRA A;  1HXC A;  3ACY A;  1N21 A;  4NFK F;  2AEK A;  3KRA B;  3ZL6 A;  3QKC A;  3WCA A;  5CG6 A;  5AFX A;  1RQI A;  5H9D A;  5JV0 F;  3NF2 A;  5ILJ A;  3AQB B;  3EGT A;  3LSN A;  4N9U A;  3LJI A;  3ZMC A;  4GP1 A;  3NPK A;  3V1V A;  4LPG F;  1EZF A;  3MZV A;  3OYR A;  3WCF A;  4LIX A;  5IKH A;  2PS5 A;  3OAB A;  4OMH A;  1N22 A;  4H5D F;  5B01 A;  3OAB B;  3DYF A;  4RXD A;  2H8O A;  5ERN A;  1N1B A;  5C05 A;  5ILI A;  4JXN A;  4OKM A;  2OA6 A;  1DI1 A;  3TC1 A;  1YYQ A;  3WE9 A;  5A0J A;  4XQS F;  3WCM A;  1VG6 A;  3OAC B;  5E8H A;  3N3D A;  3N5H F;  3VJB A;  1HX9 A;  4H5E F;  4HD1 A;  3N49 F;  3P5R A;  5A0I A;  4K10 A;  2Z4Z A;  1VG2 A; 
#chains in the Genus database with same CATH topology
 2F92 F;  3WCL A;  3G4F A;  4F6X A;  5ILK A;  1WMW A;  3WCD A;  3SDU A;  4LOB A;  5B0I A;  4H5C F;  1V4K A;  1ZW5 A;  3M00 A;  1RTR A;  1YYT A;  3DYH A;  3WCH A;  3KRF A;  5IL3 A;  2Z4W A;  4RNQ A;  5B02 A;  2ZEU A;  4QPF A;  3N1W F;  3KRF B;  2AET A;  4GAX A;  3WCE A;  2E4O A;  4LZC A;  4P0V A;  4P0X A;  5IK9 A;  2F7M F;  5DW7 A;  4JVJ F;  3EFQ A;  3ID0 A;  4LFE A;  4RYP A;  3WEF A;  5ILD A;  5B00 A;  2O1O A;  4DHD A;  3S4J A;  2Q58 A;  4P0W A;  2E8U A;  1UBX A;  2Q9Y A;  1YHM A;  3M01 A;  3CC9 A;  4N1Z F;  3M9U A;  2PS4 A;  3VJ8 A;  2ZCR A;  5ILY A;  2J5C A;  5E8L A;  4KVW A;  5B0L A;  2EWG A;  5DJP F;  5IK0 A;  2Z50 A;  3KRO A;  1YHL A;  4NFJ F;  3VJC A;  2DH4 A;  3KRO B;  1V4H A;  2AZJ A;  2E94 A;  3LG5 A;  2Z52 A;  3PDE A;  1UBY A;  3RMG A;  5B0K A;  5IMP A;  4E9Z A;  4KQS A;  3M02 A;  3N6K F;  3VJD A;  3ICZ A;  1WL3 A;  3WEI A;  3KRP B;  4JYX A;  5KSX F;  3ACW A;  5HN8 A;  3WJK A;  4GP2 A;  3Q1O A;  4JZX A;  5AEL A;  1JFG A;  3RYE A;  1VG3 A;  1YQ7 A;  3VJE A;  3N0F A;  4Q23 A;  3P41 A;  5HN9 A;  5AHU B;  1N1Z A;  1KIY A;  5JV1 F;  4KVY A;  4F6V A;  1HM7 A;  3OAC A;  3TFV A;  3N45 F;  4XQR F;  4KVD A;  3WCG A;  4DEM F;  5DJV F;  3WEJ A;  5E8K A;  4DI5 A;  4OMG A;  3AE0 A;  1V4I A;  3WCI A;  3P5P A;  5HN7 A;  3ICN A;  3TS7 A;  1WL0 A;  4LTV A;  2ZEV A;  2OGD A;  3N0G A;  3NRI A;  3LOM A;  3N46 F;  5EAS A;  5ERO A;  5IMI A;  2Q9Z A;  4L2X F;  3B7L A;  3P8R A;  4DWB A;  1VG7 A;  3LGZ B;  3ICK A;  2AEL A;  4PVX F;  1RQJ A;  5B03 A;  2E8T A;  5IN8 A;  3SDV A;  4E9U A;  5IK6 A;  4RXA A;  3WCB A;  4MC8 A;  3TFP A;  4RXE A;  3ADZ A;  2Z78 A;  3WJN A;  3BNY A;  2FTZ A;  3IBA A;  3WEG A;  2J1P A;  4JXY A;  1V4J A;  5ILZ A;  5IMN A;  3AQ0 A;  2ZCS A;  1PS1 A;  2F8Z F;  1WKZ A;  2ZY1 A;  4LZ0 A;  2F8C F;  4KK2 A;  3WSA A;  2Z7I A;  3S9V A;  2VF6 A;  4MC0 A;  3VJA A;  3KBK A;  3N1V F;  5DGN F;  5IM1 A;  3BNX A;  2E8V A;  3VJ9 A;  5ERM A;  5ER8 A;  4OKZ A;  5DGS F;  4FJQ A;  3ZMB A;  3ICM A;  2E90 A;  4FP4 A;  5DHK A;  4ZQ8 A;  5DZ2 A;  5DJR F;  4JZB A;  1WL1 A;  2P1C A;  2OPM A;  4EA1 A;  4NUA A;  1N24 A;  3Q30 A;  5EAT A;  4LFV F;  3V66 A;  3CP6 A;  1YV5 A;  4NKF A;  2F89 F;  1HM4 A;  3KRP A;  3WEH A;  4DXJ A;  4LUU A;  2AZL A;  5IL8 A;  3SAE A;  3WCJ A;  2E8X A;  3LGK A;  3SDR A;  4LXW A;  5JV2 F;  3LDW A;  2E92 A;  3KB9 A;  5JUZ F;  5DHI A;  2ZCO A;  1HXA A;  4KVI A;  4QXS F;  2I19 A;  5DIQ F;  2AZK A;  3P8L A;  4GA3 A;  3UCA A;  4E1E A;  5HNA A;  4KPJ A;  4LFG A;  4KWD A;  1YHK A;  2Z4Y A;  3SDT A;  3QQV A;  1UBV A;  1JFA A;  1VG4 A;  2FOR A;  3MAV A;  4KFA A;  3ZOU A;  1V4E A;  2PS8 A;  4KKM A;  2ONH A;  4LPH F;  4DWG A;  4NKE A;  1KIZ A;  3PH7 A;  3V1X A;  2E91 A;  3ZCD A;  1UBW A;  3IPI A;  3WC9 A;  4EA0 A;  5IVG A;  2Q80 A;  3PYA A;  3LVS A;  4NG6 A;  2PS6 A;  1YJ4 A;  5CG5 A;  3TFN A;  2ONG A;  4MC3 A;  5A0K A;  2Z7H A;  3RYW A;  4LA5 A;  4UMJ A;  3LZ9 A;  1DGP A;  4LLT A;  5ILH A;  4KQ5 A;  2PS7 A;  5JA0 F;  3LLW A;  3WCC A;  3W7F A;  3N3L F;  1HXG A;  3ACX A;  5B0J A;  1N23 A;  5IKA A;  2E95 A;  2F94 F;  3N5J F;  4RXC A;  4LLS A;  1WY0 A;  2RAH A;  3Q2Z A;  3LEE A;  3AQC B;  3PYB A;  1YYR A;  3WEK A;  2ZCQ A;  3M0G A;  4KQU A;  1WL2 A;  3LK5 A;  2E93 A;  3NPR A;  3G4D A;  4WK5 A;  2F9K F;  4XQT F;  4KPD A;  5DGM F;  4DZW A;  1YYU A;  2QIS A;  1YYS A;  2Z4X A;  5B0M A;  3WJO A;  3RBM A;  4F62 A;  1FPS A;  3ASX A;  3SDQ A;  4EA2 A;  2OPN A;  3DYG A;  4LA6 A;  5I1U A;  2J1O A;  3APZ A;  5AYP A;  4NFI F;  1N20 A;  5EAU A;  3KRC A;  4KUX A;  4PVY F;  2Z4V A;  3Q2Q A;  3WSB A;  3KRC B;  3PKO A;  4OGU A;  4LZ3 A;  3EZ3 A;  2E8W A;  4LTZ A;  3CKE A;  3LMD A;  3KRA A;  1HXC A;  3ACY A;  1N21 A;  4NFK F;  2AEK A;  3KRA B;  3ZL6 A;  3QKC A;  3WCA A;  5CG6 A;  5AFX A;  1RQI A;  5H9D A;  5JV0 F;  3NF2 A;  5ILJ A;  3AQB B;  3EGT A;  3LSN A;  4N9U A;  3LJI A;  3ZMC A;  4GP1 A;  3NPK A;  3V1V A;  4LPG F;  1EZF A;  3MZV A;  3OYR A;  3WCF A;  4LIX A;  5IKH A;  2PS5 A;  3OAB A;  4OMH A;  1N22 A;  4H5D F;  5B01 A;  3OAB B;  3DYF A;  4RXD A;  2H8O A;  5ERN A;  1N1B A;  5C05 A;  5ILI A;  4JXN A;  4OKM A;  2OA6 A;  1DI1 A;  3TC1 A;  1YYQ A;  3WE9 A;  5A0J A;  4XQS F;  3WCM A;  1VG6 A;  3OAC B;  5E8H A;  3N3D A;  3N5H F;  3VJB A;  1HX9 A;  4H5E F;  4HD1 A;  3N49 F;  3P5R A;  5A0I A;  4K10 A;  2Z4Z A;  1VG2 A; 
#chains in the Genus database with same CATH homology
 2F92 F;  3WCL A;  3G4F A;  4F6X A;  5ILK A;  1WMW A;  3WCD A;  3SDU A;  4LOB A;  5B0I A;  4H5C F;  1V4K A;  1ZW5 A;  3M00 A;  1RTR A;  1YYT A;  3DYH A;  3WCH A;  3KRF A;  5IL3 A;  2Z4W A;  4RNQ A;  5B02 A;  2ZEU A;  4QPF A;  3N1W F;  3KRF B;  2AET A;  4GAX A;  3WCE A;  2E4O A;  4LZC A;  4P0V A;  4P0X A;  5IK9 A;  2F7M F;  5DW7 A;  4JVJ F;  3EFQ A;  3ID0 A;  4LFE A;  4RYP A;  3WEF A;  5ILD A;  5B00 A;  2O1O A;  4DHD A;  3S4J A;  2Q58 A;  4P0W A;  2E8U A;  1UBX A;  2Q9Y A;  1YHM A;  3M01 A;  3CC9 A;  4N1Z F;  3M9U A;  2PS4 A;  3VJ8 A;  2ZCR A;  5ILY A;  2J5C A;  5E8L A;  4KVW A;  5B0L A;  2EWG A;  5DJP F;  5IK0 A;  2Z50 A;  3KRO A;  1YHL A;  4NFJ F;  3VJC A;  2DH4 A;  3KRO B;  1V4H A;  2AZJ A;  2E94 A;  3LG5 A;  2Z52 A;  3PDE A;  1UBY A;  3RMG A;  5B0K A;  5IMP A;  4E9Z A;  4KQS A;  3M02 A;  3N6K F;  3VJD A;  3ICZ A;  1WL3 A;  3WEI A;  3KRP B;  4JYX A;  5KSX F;  3ACW A;  5HN8 A;  3WJK A;  4GP2 A;  3Q1O A;  4JZX A;  5AEL A;  1JFG A;  3RYE A;  1VG3 A;  1YQ7 A;  3VJE A;  3N0F A;  4Q23 A;  3P41 A;  5HN9 A;  5AHU B;  1N1Z A;  1KIY A;  5JV1 F;  4KVY A;  4F6V A;  1HM7 A;  3OAC A;  3TFV A;  3N45 F;  4XQR F;  4KVD A;  3WCG A;  4DEM F;  5DJV F;  3WEJ A;  5E8K A;  4DI5 A;  4OMG A;  3AE0 A;  1V4I A;  3WCI A;  3P5P A;  5HN7 A;  3ICN A;  3TS7 A;  1WL0 A;  4LTV A;  2ZEV A;  2OGD A;  3N0G A;  3NRI A;  3LOM A;  3N46 F;  5EAS A;  5ERO A;  5IMI A;  2Q9Z A;  4L2X F;  3B7L A;  3P8R A;  4DWB A;  1VG7 A;  3LGZ B;  3ICK A;  2AEL A;  4PVX F;  1RQJ A;  5B03 A;  2E8T A;  5IN8 A;  3SDV A;  4E9U A;  5IK6 A;  4RXA A;  3WCB A;  4MC8 A;  3TFP A;  4RXE A;  3ADZ A;  2Z78 A;  3WJN A;  3BNY A;  2FTZ A;  3IBA A;  3WEG A;  2J1P A;  4JXY A;  1V4J A;  5ILZ A;  5IMN A;  3AQ0 A;  2ZCS A;  1PS1 A;  2F8Z F;  1WKZ A;  2ZY1 A;  4LZ0 A;  2F8C F;  4KK2 A;  3WSA A;  2Z7I A;  3S9V A;  2VF6 A;  4MC0 A;  3VJA A;  3KBK A;  3N1V F;  5DGN F;  5IM1 A;  3BNX A;  2E8V A;  3VJ9 A;  5ERM A;  5ER8 A;  4OKZ A;  5DGS F;  4FJQ A;  3ZMB A;  3ICM A;  2E90 A;  4FP4 A;  5DHK A;  4ZQ8 A;  5DZ2 A;  5DJR F;  4JZB A;  1WL1 A;  2P1C A;  2OPM A;  4EA1 A;  4NUA A;  1N24 A;  3Q30 A;  5EAT A;  4LFV F;  3V66 A;  3CP6 A;  1YV5 A;  4NKF A;  2F89 F;  1HM4 A;  3KRP A;  3WEH A;  4DXJ A;  4LUU A;  2AZL A;  5IL8 A;  3SAE A;  3WCJ A;  2E8X A;  3LGK A;  3SDR A;  4LXW A;  5JV2 F;  3LDW A;  2E92 A;  3KB9 A;  5JUZ F;  5DHI A;  2ZCO A;  1HXA A;  4KVI A;  4QXS F;  2I19 A;  5DIQ F;  2AZK A;  3P8L A;  4GA3 A;  3UCA A;  4E1E A;  5HNA A;  4KPJ A;  4LFG A;  4KWD A;  1YHK A;  2Z4Y A;  3SDT A;  3QQV A;  1UBV A;  1JFA A;  1VG4 A;  2FOR A;  3MAV A;  4KFA A;  3ZOU A;  1V4E A;  2PS8 A;  4KKM A;  2ONH A;  4LPH F;  4DWG A;  4NKE A;  1KIZ A;  3PH7 A;  3V1X A;  2E91 A;  3ZCD A;  1UBW A;  3IPI A;  3WC9 A;  4EA0 A;  5IVG A;  2Q80 A;  3PYA A;  3LVS A;  4NG6 A;  2PS6 A;  1YJ4 A;  5CG5 A;  3TFN A;  2ONG A;  4MC3 A;  5A0K A;  2Z7H A;  3RYW A;  4LA5 A;  4UMJ A;  3LZ9 A;  1DGP A;  4LLT A;  5ILH A;  4KQ5 A;  2PS7 A;  5JA0 F;  3LLW A;  3WCC A;  3W7F A;  3N3L F;  1HXG A;  3ACX A;  5B0J A;  1N23 A;  5IKA A;  2E95 A;  2F94 F;  3N5J F;  4RXC A;  4LLS A;  1WY0 A;  2RAH A;  3Q2Z A;  3LEE A;  3AQC B;  3PYB A;  1YYR A;  3WEK A;  2ZCQ A;  3M0G A;  4KQU A;  1WL2 A;  3LK5 A;  2E93 A;  3NPR A;  3G4D A;  4WK5 A;  2F9K F;  4XQT F;  4KPD A;  5DGM F;  4DZW A;  1YYU A;  2QIS A;  1YYS A;  2Z4X A;  5B0M A;  3WJO A;  3RBM A;  4F62 A;  1FPS A;  3ASX A;  3SDQ A;  4EA2 A;  2OPN A;  3DYG A;  4LA6 A;  5I1U A;  2J1O A;  3APZ A;  5AYP A;  4NFI F;  1N20 A;  5EAU A;  3KRC A;  4KUX A;  4PVY F;  2Z4V A;  3Q2Q A;  3WSB A;  3KRC B;  3PKO A;  4OGU A;  4LZ3 A;  3EZ3 A;  2E8W A;  4LTZ A;  3CKE A;  3LMD A;  3KRA A;  1HXC A;  3ACY A;  1N21 A;  4NFK F;  2AEK A;  3KRA B;  3ZL6 A;  3QKC A;  3WCA A;  5CG6 A;  5AFX A;  1RQI A;  5H9D A;  5JV0 F;  3NF2 A;  5ILJ A;  3AQB B;  3EGT A;  3LSN A;  4N9U A;  3LJI A;  3ZMC A;  4GP1 A;  3NPK A;  3V1V A;  4LPG F;  1EZF A;  3MZV A;  3OYR A;  3WCF A;  4LIX A;  5IKH A;  2PS5 A;  3OAB A;  4OMH A;  1N22 A;  4H5D F;  5B01 A;  3OAB B;  3DYF A;  4RXD A;  2H8O A;  5ERN A;  1N1B A;  5C05 A;  5ILI A;  4JXN A;  4OKM A;  2OA6 A;  1DI1 A;  3TC1 A;  1YYQ A;  3WE9 A;  5A0J A;  4XQS F;  3WCM A;  1VG6 A;  3OAC B;  5E8H A;  3N3D A;  3N5H F;  3VJB A;  1HX9 A;  4H5E F;  4HD1 A;  3N49 F;  3P5R A;  5A0I A;  4K10 A;  2Z4Z A;  1VG2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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