4DXJA

Crystal structure of trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(n-propylamino)ethane-1,1-diyl]bisphosphonic acid and mg2+
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
362
structure length
362
Chain Sequence
MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLFVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGDKDPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRKK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/transferase inhibitor
molecule keywords Farnesyl pyrophosphate synthase
publication title Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.
pubmed doi rcsb
source organism Trypanosoma cruzi
total genus 148
structure length 362
sequence length 362
chains with identical sequence B, C
ec nomenclature ec 2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
pdb deposition date 2012-02-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4dxjA00
3QKCA 2ONGA 3AQCB 3WCGA 3PYAA 5I1UA 5JUZF 5ILYA 5IKHA 2AEKA 4P0XA 4NKEA 5IK6A 2O1OA 3NF2A 3N1WF 4KUXA 2E95A 3OYRA 3CKEA 5EASA 5ILIA 2E8WA 4JZXA 3N0GA 4KQUA 4LFGA 5DJRF 2Z50A 4F62A 3DYGA 4DXJA 4LOBA 5IL8A 3TC1A 4LFEA 1WMWA 3LK5A 5KSXF 5HN8A 5DW7A 5DGSF 3EGTA 3KRAB 2Z4WA 1DI1A 5ER8A 4FJQA 1N21A 5EAUA 4L2XF 4XQSF 4EA1A 3KRCB 3MAVA 5HN9A 5B02A 3WCHA 3PYBA 5IK0A 3ASXA 3KRFA 5ILZA 1RQJA 5DIQF 3WCMA 1VG6A 2H8OA 2VF6A 3LDWA 3Q2ZA 2E4OA 3M02A 3ACYA 5C05A 2RAHA 3N0FA 3G4FA 5IKAA 3WC9A 3N6KF 4LLTA 5DJPF 1DGPA 4GA3A 1JFGA 3QQVA 3V1XA 1WL1A 5JV2F 2ZCRA 4OKZA 3MZVA 1UBVA 4OKMA 4LUUA 3ICNA 1YHLA 3P8LA 3N3DA 3EZ3A 1WL3A 3KB9A 1V4IA 4LZ3A 3N49F 2E91A 3VJDA 1N24A 2E8TA 3PKOA 4LZCA 3BNXA 4P0VA 3KRPA 3SDVA 3CP6A 2Z7HA 2AETA 4EA2A 4WK5A 4DHDA 3WCIA 3WEGA 3M0GA 3ZCDA 4KKMA 4KPJA 2Z4VA 2Z78A 4H5EF 3KRFB 4H5CF 3N1VF 4LFVF 4KVIA 2F94F 4DWGA 1N1BA 3M9UA 1PS1A 4MC3A 1YV5A 3N3LF 3WCDA 5HN7A 5ERMA 4JZBA 3OACA 5ILJA 1WKZA 5E8KA 5A0KA 4UMJA 2E8XA 3WEFA 1N22A 1WL0A 5IMPA 3AE0A 4DZWA 5A0IA 2Z52A 3S9VA 5B0MA 1RTRA 5B01A 1YHMA 3WEIA 4LXWA 1YYTA 3N46F 3WCFA 4RXDA 2AZJA 3WE9A 3WCCA 2F9KF 3VJBA 3KROA 3LGZB 4JVJF 3WCLA 1V4KA 1VG2A 5B0IA 4F6XA 3WCBA 3LVSA 4MC8A 2PS5A 1FPSA 2OGDA 4P0WA 2ONHA 3LLWA 1WL2A 1UBWA 5B00A 2E94A 3UCAA 3WEHA 3WCJA 4OMGA 3WJKA 4E1EA 5IN8A 3WJOA 2PS6A 4HD1A 3S4JA 2PS4A 3Q30A 3SAEA 2F8ZF 5IL3A 1N1ZA 3OABA 3TFNA 3M00A 4XQTF 2E93A 1V4HA 3OACB 3P41A 2F89F 4EA0A 4QPFA 4E9ZA 4RXAA 4RNQA 2OPMA 2Q58A 2ZCSA 5E8LA 3LZ9A 2E8VA 1V4JA 1WY0A 5AFXA 5B0LA 4KQ5A 3NPRA 2P1CA 2Z4ZA 2Z4YA 2Z7IA 3RYEA 5IK9A 3N45F 2Z4XA 2E8UA 1JFAA 3AQBB 1VG3A 4LA6A 3APZA 5AYPA 2EWGA 2PS8A 4F6VA 3P8RA 2J5CA 3ICKA 3WCAA 5CG6A 5H9DA 3ZL6A 3NRIA 4OGUA 5EROA 4LTVA 5AHUB 2ZCQA 3LJIA 5ILKA 5B03A 3VJ8A 4PVXF 3CC9A 3LG5A 4KVYA 4LLSA 4XQRF 3LSNA 1YYQA 5ERNA 3IPIA 3OABB 3PDEA 2ZCOA 5DJVF 4ZQ8A 5IMIA 4NFKF 3ACWA 1KIYA 1KIZA 2AELA 2J1PA 4DEMF 3PH7A 5DHIA 3VJAA 4DI5A 5JA0F 4LIXA 2PS7A 4NUAA 2F7MF 4GP2A 1YHKA 3V66A 5DGMF 5DHKA 3LOMA 3SDQA 1VG7A 4RXEA 3SDTA 3ZMBA 4KFAA 3LEEA 3KRPB 1UBYA 4GP1A 5EATA 4E9UA 5E8HA 2Q80A 3TFPA 3KBKA 5DZ2A 5JV0F 5ILHA 2ZEUA 4GAXA 3P5PA 4PVYF 4LZ0A 1V4EA 1YYSA 3ID0A 1UBXA 5B0JA 1HXCA 4NFIF 3LGKA 2OPNA 3VJEA 3WCEA 1EZFA 1HXGA 2F92F 1YJ4A 3ADZA 2DH4A 4KK2A 1YQ7A 1HX9A 4LA5A 2E90A 4MC0A 3TFVA 3DYFA 3ACXA 5IM1A 3LMDA 2Q9YA 2AZLA 1N23A 5B0KA 4N1ZF 3ICMA 3ICZA 2ZEVA 4KPDA 2I19A 3N5JF 4K10A 1RQIA 3KROB 1ZW5A 3DYHA 4RYPA 4JYXA 2AZKA 5DGNF 4NFJF 5HNAA 3G4DA 2QISA 1YYRA 3WSBA 4RXCA 3RBMA 3P5RA 1VG4A 3RYWA 3ZOUA 3SDUA 3WSAA 4N9UA 3SDRA 3N5HF 5ILDA 2FTZA 5A0JA 5CG5A 1N20A 3W7FA 3KRAA 4Q23A 4JXYA 3VJCA 5IVGA 1HXAA 3KRCA 3B7LA 3V1VA 4LPHF 4FP4A 3M01A 4NG6A 4LTZA 2F8CF 3AQ0A 5AELA 2E92A 2J1OA 2OA6A 3VJ9A 4KQSA 3WEKA 4LPGF 4OMHA 3WJNA 4KWDA 5JV1F 2Q9ZA 4KVWA 3Q2QA 4KVDA 3RMGA 3BNYA 1HM7A 4QXSF 3NPKA 3Q1OA 4H5DF 3ZMCA 4NKFA 1YYUA 2ZY1A 3WEJA 3IBAA 1HM4A 4JXNA 3TS7A 2FORA 3EFQA 4DWBA 5IMNA
chains in the Genus database with same CATH superfamily
3QKCA 2ONGA 3AQCB 3WCGA 3PYAA 5I1UA 5JUZF 5ILYA 5IKHA 2AEKA 4P0XA 4NKEA 5IK6A 2O1OA 3NF2A 3N1WF 4KUXA 2E95A 3OYRA 3CKEA 5EASA 5ILIA 2E8WA 4JZXA 3N0GA 4KQUA 4LFGA 5DJRF 2Z50A 4F62A 3DYGA 4DXJA 4LOBA 5IL8A 3TC1A 4LFEA 1WMWA 3LK5A 5KSXF 5HN8A 5DW7A 5DGSF 3EGTA 3KRAB 2Z4WA 1DI1A 5ER8A 4FJQA 1N21A 5EAUA 4L2XF 4XQSF 4EA1A 3KRCB 3MAVA 5HN9A 5B02A 3WCHA 3PYBA 5IK0A 3ASXA 3KRFA 5ILZA 1RQJA 5DIQF 3WCMA 1VG6A 2H8OA 2VF6A 3LDWA 3Q2ZA 2E4OA 3M02A 3ACYA 5C05A 2RAHA 3N0FA 3G4FA 5IKAA 3WC9A 3N6KF 4LLTA 5DJPF 1DGPA 4GA3A 1JFGA 3QQVA 3V1XA 1WL1A 5JV2F 2ZCRA 4OKZA 3MZVA 1UBVA 4OKMA 4LUUA 3ICNA 1YHLA 3P8LA 3N3DA 3EZ3A 1WL3A 3KB9A 1V4IA 4LZ3A 3N49F 2E91A 3VJDA 1N24A 2E8TA 3PKOA 4LZCA 3BNXA 4P0VA 3KRPA 3SDVA 3CP6A 2Z7HA 2AETA 4EA2A 4WK5A 4DHDA 3WCIA 3WEGA 3M0GA 3ZCDA 4KKMA 4KPJA 2Z4VA 2Z78A 4H5EF 3KRFB 4H5CF 3N1VF 4LFVF 4KVIA 2F94F 4DWGA 1N1BA 3M9UA 1PS1A 4MC3A 1YV5A 3N3LF 3WCDA 5HN7A 5ERMA 4JZBA 3OACA 5ILJA 1WKZA 5E8KA 5A0KA 4UMJA 2E8XA 3WEFA 1N22A 1WL0A 5IMPA 3AE0A 4DZWA 5A0IA 2Z52A 3S9VA 5B0MA 1RTRA 5B01A 1YHMA 3WEIA 4LXWA 1YYTA 3N46F 3WCFA 4RXDA 2AZJA 3WE9A 3WCCA 2F9KF 3VJBA 3KROA 3LGZB 4JVJF 3WCLA 1V4KA 1VG2A 5B0IA 4F6XA 3WCBA 3LVSA 4MC8A 2PS5A 1FPSA 2OGDA 4P0WA 2ONHA 3LLWA 1WL2A 1UBWA 5B00A 2E94A 3UCAA 3WEHA 3WCJA 4OMGA 3WJKA 4E1EA 5IN8A 3WJOA 2PS6A 4HD1A 3S4JA 2PS4A 3Q30A 3SAEA 2F8ZF 5IL3A 1N1ZA 3OABA 3TFNA 3M00A 4XQTF 2E93A 1V4HA 3OACB 3P41A 2F89F 4EA0A 4QPFA 4E9ZA 4RXAA 4RNQA 2OPMA 2Q58A 2ZCSA 5E8LA 3LZ9A 2E8VA 1V4JA 1WY0A 5AFXA 5B0LA 4KQ5A 3NPRA 2P1CA 2Z4ZA 2Z4YA 2Z7IA 3RYEA 5IK9A 3N45F 2Z4XA 2E8UA 1JFAA 3AQBB 1VG3A 4LA6A 3APZA 5AYPA 2EWGA 2PS8A 4F6VA 3P8RA 2J5CA 3ICKA 3WCAA 5CG6A 5H9DA 3ZL6A 3NRIA 4OGUA 5EROA 4LTVA 5AHUB 2ZCQA 3LJIA 5ILKA 5B03A 3VJ8A 4PVXF 3CC9A 3LG5A 4KVYA 4LLSA 4XQRF 3LSNA 1YYQA 5ERNA 3IPIA 3OABB 3PDEA 2ZCOA 5DJVF 4ZQ8A 5IMIA 4NFKF 3ACWA 1KIYA 1KIZA 2AELA 2J1PA 4DEMF 3PH7A 5DHIA 3VJAA 4DI5A 5JA0F 4LIXA 2PS7A 4NUAA 2F7MF 4GP2A 1YHKA 3V66A 5DGMF 5DHKA 3LOMA 3SDQA 1VG7A 4RXEA 3SDTA 3ZMBA 4KFAA 3LEEA 3KRPB 1UBYA 4GP1A 5EATA 4E9UA 5E8HA 2Q80A 3TFPA 3KBKA 5DZ2A 5JV0F 5ILHA 2ZEUA 4GAXA 3P5PA 4PVYF 4LZ0A 1V4EA 1YYSA 3ID0A 1UBXA 5B0JA 1HXCA 4NFIF 3LGKA 2OPNA 3VJEA 3WCEA 1EZFA 1HXGA 2F92F 1YJ4A 3ADZA 2DH4A 4KK2A 1YQ7A 1HX9A 4LA5A 2E90A 4MC0A 3TFVA 3DYFA 3ACXA 5IM1A 3LMDA 2Q9YA 2AZLA 1N23A 5B0KA 4N1ZF 3ICMA 3ICZA 2ZEVA 4KPDA 2I19A 3N5JF 4K10A 1RQIA 3KROB 1ZW5A 3DYHA 4RYPA 4JYXA 2AZKA 5DGNF 4NFJF 5HNAA 3G4DA 2QISA 1YYRA 3WSBA 4RXCA 3RBMA 3P5RA 1VG4A 3RYWA 3ZOUA 3SDUA 3WSAA 4N9UA 3SDRA 3N5HF 5ILDA 2FTZA 5A0JA 5CG5A 1N20A 3W7FA 3KRAA 4Q23A 4JXYA 3VJCA 5IVGA 1HXAA 3KRCA 3B7LA 3V1VA 4LPHF 4FP4A 3M01A 4NG6A 4LTZA 2F8CF 3AQ0A 5AELA 2E92A 2J1OA 2OA6A 3VJ9A 4KQSA 3WEKA 4LPGF 4OMHA 3WJNA 4KWDA 5JV1F 2Q9ZA 4KVWA 3Q2QA 4KVDA 3RMGA 3BNYA 1HM7A 4QXSF 3NPKA 3Q1OA 4H5DF 3ZMCA 4NKFA 1YYUA 2ZY1A 3WEJA 3IBAA 1HM4A 4JXNA 3TS7A 2FORA 3EFQA 4DWBA 5IMNA
chains in the Genus database with same CATH topology
3QKCA 2ONGA 3AQCB 3WCGA 3PYAA 5I1UA 5JUZF 5ILYA 5IKHA 2AEKA 4P0XA 4NKEA 5IK6A 2O1OA 3NF2A 3N1WF 4KUXA 2E95A 3OYRA 3CKEA 5EASA 5ILIA 2E8WA 4JZXA 3N0GA 4KQUA 4LFGA 5DJRF 2Z50A 4F62A 3DYGA 4DXJA 4LOBA 5IL8A 3TC1A 4LFEA 1WMWA 3LK5A 5KSXF 5HN8A 5DW7A 5DGSF 3EGTA 3KRAB 2Z4WA 1DI1A 5ER8A 4FJQA 1N21A 5EAUA 4L2XF 4XQSF 4EA1A 3KRCB 3MAVA 5HN9A 5B02A 3WCHA 3PYBA 5IK0A 3ASXA 3KRFA 5ILZA 1RQJA 5DIQF 3WCMA 1VG6A 2H8OA 2VF6A 3LDWA 3Q2ZA 2E4OA 3M02A 3ACYA 5C05A 2RAHA 3N0FA 3G4FA 5IKAA 3WC9A 3N6KF 4LLTA 5DJPF 1DGPA 4GA3A 1JFGA 3QQVA 3V1XA 1WL1A 5JV2F 2ZCRA 4OKZA 3MZVA 1UBVA 4OKMA 4LUUA 3ICNA 1YHLA 3P8LA 3N3DA 3EZ3A 1WL3A 3KB9A 1V4IA 4LZ3A 3N49F 2E91A 3VJDA 1N24A 2E8TA 3PKOA 4LZCA 3BNXA 4P0VA 3KRPA 3SDVA 3CP6A 2Z7HA 2AETA 4EA2A 4WK5A 4DHDA 3WCIA 3WEGA 3M0GA 3ZCDA 4KKMA 4KPJA 2Z4VA 2Z78A 4H5EF 3KRFB 4H5CF 3N1VF 4LFVF 4KVIA 2F94F 4DWGA 1N1BA 3M9UA 1PS1A 4MC3A 1YV5A 3N3LF 3WCDA 5HN7A 5ERMA 4JZBA 3OACA 5ILJA 1WKZA 5E8KA 5A0KA 4UMJA 2E8XA 3WEFA 1N22A 1WL0A 5IMPA 3AE0A 4DZWA 5A0IA 2Z52A 3S9VA 5B0MA 1RTRA 5B01A 1YHMA 3WEIA 4LXWA 1YYTA 3N46F 3WCFA 4RXDA 2AZJA 3WE9A 3WCCA 2F9KF 3VJBA 3KROA 3LGZB 4JVJF 3WCLA 1V4KA 1VG2A 5B0IA 4F6XA 3WCBA 3LVSA 4MC8A 2PS5A 1FPSA 2OGDA 4P0WA 2ONHA 3LLWA 1WL2A 1UBWA 5B00A 2E94A 3UCAA 3WEHA 3WCJA 4OMGA 3WJKA 4E1EA 5IN8A 3WJOA 2PS6A 4HD1A 3S4JA 2PS4A 3Q30A 3SAEA 2F8ZF 5IL3A 1N1ZA 3OABA 3TFNA 3M00A 4XQTF 2E93A 1V4HA 3OACB 3P41A 2F89F 4EA0A 4QPFA 4E9ZA 4RXAA 4RNQA 2OPMA 2Q58A 2ZCSA 5E8LA 3LZ9A 2E8VA 1V4JA 1WY0A 5AFXA 5B0LA 4KQ5A 3NPRA 2P1CA 2Z4ZA 2Z4YA 2Z7IA 3RYEA 5IK9A 3N45F 2Z4XA 2E8UA 1JFAA 3AQBB 1VG3A 4LA6A 3APZA 5AYPA 2EWGA 2PS8A 4F6VA 3P8RA 2J5CA 3ICKA 3WCAA 5CG6A 5H9DA 3ZL6A 3NRIA 4OGUA 5EROA 4LTVA 5AHUB 2ZCQA 3LJIA 5ILKA 5B03A 3VJ8A 4PVXF 3CC9A 3LG5A 4KVYA 4LLSA 4XQRF 3LSNA 1YYQA 5ERNA 3IPIA 3OABB 3PDEA 2ZCOA 5DJVF 4ZQ8A 5IMIA 4NFKF 3ACWA 1KIYA 1KIZA 2AELA 2J1PA 4DEMF 3PH7A 5DHIA 3VJAA 4DI5A 5JA0F 4LIXA 2PS7A 4NUAA 2F7MF 4GP2A 1YHKA 3V66A 5DGMF 5DHKA 3LOMA 3SDQA 1VG7A 4RXEA 3SDTA 3ZMBA 4KFAA 3LEEA 3KRPB 1UBYA 4GP1A 5EATA 4E9UA 5E8HA 2Q80A 3TFPA 3KBKA 5DZ2A 5JV0F 5ILHA 2ZEUA 4GAXA 3P5PA 4PVYF 4LZ0A 1V4EA 1YYSA 3ID0A 1UBXA 5B0JA 1HXCA 4NFIF 3LGKA 2OPNA 3VJEA 3WCEA 1EZFA 1HXGA 2F92F 1YJ4A 3ADZA 2DH4A 4KK2A 1YQ7A 1HX9A 4LA5A 2E90A 4MC0A 3TFVA 3DYFA 3ACXA 5IM1A 3LMDA 2Q9YA 2AZLA 1N23A 5B0KA 4N1ZF 3ICMA 3ICZA 2ZEVA 4KPDA 2I19A 3N5JF 4K10A 1RQIA 3KROB 1ZW5A 3DYHA 4RYPA 4JYXA 2AZKA 5DGNF 4NFJF 5HNAA 3G4DA 2QISA 1YYRA 3WSBA 4RXCA 3RBMA 3P5RA 1VG4A 3RYWA 3ZOUA 3SDUA 3WSAA 4N9UA 3SDRA 3N5HF 5ILDA 2FTZA 5A0JA 5CG5A 1N20A 3W7FA 3KRAA 4Q23A 4JXYA 3VJCA 5IVGA 1HXAA 3KRCA 3B7LA 3V1VA 4LPHF 4FP4A 3M01A 4NG6A 4LTZA 2F8CF 3AQ0A 5AELA 2E92A 2J1OA 2OA6A 3VJ9A 4KQSA 3WEKA 4LPGF 4OMHA 3WJNA 4KWDA 5JV1F 2Q9ZA 4KVWA 3Q2QA 4KVDA 3RMGA 3BNYA 1HM7A 4QXSF 3NPKA 3Q1OA 4H5DF 3ZMCA 4NKFA 1YYUA 2ZY1A 3WEJA 3IBAA 1HM4A 4JXNA 3TS7A 2FORA 3EFQA 4DWBA 5IMNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QKC A;  2ONG A;  3AQC B;  3WCG A;  3PYA A;  5I1U A;  5JUZ F;  5ILY A;  5IKH A;  2AEK A;  4P0X A;  4NKE A;  5IK6 A;  2O1O A;  3NF2 A;  3N1W F;  4KUX A;  2E95 A;  3OYR A;  3CKE A;  5EAS A;  5ILI A;  2E8W A;  4JZX A;  3N0G A;  4KQU A;  4LFG A;  5DJR F;  2Z50 A;  4F62 A;  3DYG A;  4DXJ A;  4LOB A;  5IL8 A;  3TC1 A;  4LFE A;  1WMW A;  3LK5 A;  5KSX F;  5HN8 A;  5DW7 A;  5DGS F;  3EGT A;  3KRA B;  2Z4W A;  1DI1 A;  5ER8 A;  4FJQ A;  1N21 A;  5EAU A;  4L2X F;  4XQS F;  4EA1 A;  3KRC B;  3MAV A;  5HN9 A;  5B02 A;  3WCH A;  3PYB A;  5IK0 A;  3ASX A;  3KRF A;  5ILZ A;  1RQJ A;  5DIQ F;  3WCM A;  1VG6 A;  2H8O A;  2VF6 A;  3LDW A;  3Q2Z A;  2E4O A;  3M02 A;  3ACY A;  5C05 A;  2RAH A;  3N0F A;  3G4F A;  5IKA A;  3WC9 A;  3N6K F;  4LLT A;  5DJP F;  1DGP A;  4GA3 A;  1JFG A;  3QQV A;  3V1X A;  1WL1 A;  5JV2 F;  2ZCR A;  4OKZ A;  3MZV A;  1UBV A;  4OKM A;  4LUU A;  3ICN A;  1YHL A;  3P8L A;  3N3D A;  3EZ3 A;  1WL3 A;  3KB9 A;  1V4I A;  4LZ3 A;  3N49 F;  2E91 A;  3VJD A;  1N24 A;  2E8T A;  3PKO A;  4LZC A;  3BNX A;  4P0V A;  3KRP A;  3SDV A;  3CP6 A;  2Z7H A;  2AET A;  4EA2 A;  4WK5 A;  4DHD A;  3WCI A;  3WEG A;  3M0G A;  3ZCD A;  4KKM A;  4KPJ A;  2Z4V A;  2Z78 A;  4H5E F;  3KRF B;  4H5C F;  3N1V F;  4LFV F;  4KVI A;  2F94 F;  4DWG A;  1N1B A;  3M9U A;  1PS1 A;  4MC3 A;  1YV5 A;  3N3L F;  3WCD A;  5HN7 A;  5ERM A;  4JZB A;  3OAC A;  5ILJ A;  1WKZ A;  5E8K A;  5A0K A;  4UMJ A;  2E8X A;  3WEF A;  1N22 A;  1WL0 A;  5IMP A;  3AE0 A;  4DZW A;  5A0I A;  2Z52 A;  3S9V A;  5B0M A;  1RTR A;  5B01 A;  1YHM A;  3WEI A;  4LXW A;  1YYT A;  3N46 F;  3WCF A;  4RXD A;  2AZJ A;  3WE9 A;  3WCC A;  2F9K F;  3VJB A;  3KRO A;  3LGZ B;  4JVJ F;  3WCL A;  1V4K A;  1VG2 A;  5B0I A;  4F6X A;  3WCB A;  3LVS A;  4MC8 A;  2PS5 A;  1FPS A;  2OGD A;  4P0W A;  2ONH A;  3LLW A;  1WL2 A;  1UBW A;  5B00 A;  2E94 A;  3UCA A;  3WEH A;  3WCJ A;  4OMG A;  3WJK A;  4E1E A;  5IN8 A;  3WJO A;  2PS6 A;  4HD1 A;  3S4J A;  2PS4 A;  3Q30 A;  3SAE A;  2F8Z F;  5IL3 A;  1N1Z A;  3OAB A;  3TFN A;  3M00 A;  4XQT F;  2E93 A;  1V4H A;  3OAC B;  3P41 A;  2F89 F;  4EA0 A;  4QPF A;  4E9Z A;  4RXA A;  4RNQ A;  2OPM A;  2Q58 A;  2ZCS A;  5E8L A;  3LZ9 A;  2E8V A;  1V4J A;  1WY0 A;  5AFX A;  5B0L A;  4KQ5 A;  3NPR A;  2P1C A;  2Z4Z A;  2Z4Y A;  2Z7I A;  3RYE A;  5IK9 A;  3N45 F;  2Z4X A;  2E8U A;  1JFA A;  3AQB B;  1VG3 A;  4LA6 A;  3APZ A;  5AYP A;  2EWG A;  2PS8 A;  4F6V A;  3P8R A;  2J5C A;  3ICK A;  3WCA A;  5CG6 A;  5H9D A;  3ZL6 A;  3NRI A;  4OGU A;  5ERO A;  4LTV A;  5AHU B;  2ZCQ A;  3LJI A;  5ILK A;  5B03 A;  3VJ8 A;  4PVX F;  3CC9 A;  3LG5 A;  4KVY A;  4LLS A;  4XQR F;  3LSN A;  1YYQ A;  5ERN A;  3IPI A;  3OAB B;  3PDE A;  2ZCO A;  5DJV F;  4ZQ8 A;  5IMI A;  4NFK F;  3ACW A;  1KIY A;  1KIZ A;  2AEL A;  2J1P A;  4DEM F;  3PH7 A;  5DHI A;  3VJA A;  4DI5 A;  5JA0 F;  4LIX A;  2PS7 A;  4NUA A;  2F7M F;  4GP2 A;  1YHK A;  3V66 A;  5DGM F;  5DHK A;  3LOM A;  3SDQ A;  1VG7 A;  4RXE A;  3SDT A;  3ZMB A;  4KFA A;  3LEE A;  3KRP B;  1UBY A;  4GP1 A;  5EAT A;  4E9U A;  5E8H A;  2Q80 A;  3TFP A;  3KBK A;  5DZ2 A;  5JV0 F;  5ILH A;  2ZEU A;  4GAX A;  3P5P A;  4PVY F;  4LZ0 A;  1V4E A;  1YYS A;  3ID0 A;  1UBX A;  5B0J A;  1HXC A;  4NFI F;  3LGK A;  2OPN A;  3VJE A;  3WCE A;  1EZF A;  1HXG A;  2F92 F;  1YJ4 A;  3ADZ A;  2DH4 A;  4KK2 A;  1YQ7 A;  1HX9 A;  4LA5 A;  2E90 A;  4MC0 A;  3TFV A;  3DYF A;  3ACX A;  5IM1 A;  3LMD A;  2Q9Y A;  2AZL A;  1N23 A;  5B0K A;  4N1Z F;  3ICM A;  3ICZ A;  2ZEV A;  4KPD A;  2I19 A;  3N5J F;  4K10 A;  1RQI A;  3KRO B;  1ZW5 A;  3DYH A;  4RYP A;  4JYX A;  2AZK A;  5DGN F;  4NFJ F;  5HNA A;  3G4D A;  2QIS A;  1YYR A;  3WSB A;  4RXC A;  3RBM A;  3P5R A;  1VG4 A;  3RYW A;  3ZOU A;  3SDU A;  3WSA A;  4N9U A;  3SDR A;  3N5H F;  5ILD A;  2FTZ A;  5A0J A;  5CG5 A;  1N20 A;  3W7F A;  3KRA A;  4Q23 A;  4JXY A;  3VJC A;  5IVG A;  1HXA A;  3KRC A;  3B7L A;  3V1V A;  4LPH F;  4FP4 A;  3M01 A;  4NG6 A;  4LTZ A;  2F8C F;  3AQ0 A;  5AEL A;  2E92 A;  2J1O A;  2OA6 A;  3VJ9 A;  4KQS A;  3WEK A;  4LPG F;  4OMH A;  3WJN A;  4KWD A;  5JV1 F;  2Q9Z A;  4KVW A;  3Q2Q A;  4KVD A;  3RMG A;  3BNY A;  1HM7 A;  4QXS F;  3NPK A;  3Q1O A;  4H5D F;  3ZMC A;  4NKF A;  1YYU A;  2ZY1 A;  3WEJ A;  3IBA A;  1HM4 A;  4JXN A;  3TS7 A;  2FOR A;  3EFQ A;  4DWB A;  5IMN A; 
#chains in the Genus database with same CATH topology
 3QKC A;  2ONG A;  3AQC B;  3WCG A;  3PYA A;  5I1U A;  5JUZ F;  5ILY A;  5IKH A;  2AEK A;  4P0X A;  4NKE A;  5IK6 A;  2O1O A;  3NF2 A;  3N1W F;  4KUX A;  2E95 A;  3OYR A;  3CKE A;  5EAS A;  5ILI A;  2E8W A;  4JZX A;  3N0G A;  4KQU A;  4LFG A;  5DJR F;  2Z50 A;  4F62 A;  3DYG A;  4DXJ A;  4LOB A;  5IL8 A;  3TC1 A;  4LFE A;  1WMW A;  3LK5 A;  5KSX F;  5HN8 A;  5DW7 A;  5DGS F;  3EGT A;  3KRA B;  2Z4W A;  1DI1 A;  5ER8 A;  4FJQ A;  1N21 A;  5EAU A;  4L2X F;  4XQS F;  4EA1 A;  3KRC B;  3MAV A;  5HN9 A;  5B02 A;  3WCH A;  3PYB A;  5IK0 A;  3ASX A;  3KRF A;  5ILZ A;  1RQJ A;  5DIQ F;  3WCM A;  1VG6 A;  2H8O A;  2VF6 A;  3LDW A;  3Q2Z A;  2E4O A;  3M02 A;  3ACY A;  5C05 A;  2RAH A;  3N0F A;  3G4F A;  5IKA A;  3WC9 A;  3N6K F;  4LLT A;  5DJP F;  1DGP A;  4GA3 A;  1JFG A;  3QQV A;  3V1X A;  1WL1 A;  5JV2 F;  2ZCR A;  4OKZ A;  3MZV A;  1UBV A;  4OKM A;  4LUU A;  3ICN A;  1YHL A;  3P8L A;  3N3D A;  3EZ3 A;  1WL3 A;  3KB9 A;  1V4I A;  4LZ3 A;  3N49 F;  2E91 A;  3VJD A;  1N24 A;  2E8T A;  3PKO A;  4LZC A;  3BNX A;  4P0V A;  3KRP A;  3SDV A;  3CP6 A;  2Z7H A;  2AET A;  4EA2 A;  4WK5 A;  4DHD A;  3WCI A;  3WEG A;  3M0G A;  3ZCD A;  4KKM A;  4KPJ A;  2Z4V A;  2Z78 A;  4H5E F;  3KRF B;  4H5C F;  3N1V F;  4LFV F;  4KVI A;  2F94 F;  4DWG A;  1N1B A;  3M9U A;  1PS1 A;  4MC3 A;  1YV5 A;  3N3L F;  3WCD A;  5HN7 A;  5ERM A;  4JZB A;  3OAC A;  5ILJ A;  1WKZ A;  5E8K A;  5A0K A;  4UMJ A;  2E8X A;  3WEF A;  1N22 A;  1WL0 A;  5IMP A;  3AE0 A;  4DZW A;  5A0I A;  2Z52 A;  3S9V A;  5B0M A;  1RTR A;  5B01 A;  1YHM A;  3WEI A;  4LXW A;  1YYT A;  3N46 F;  3WCF A;  4RXD A;  2AZJ A;  3WE9 A;  3WCC A;  2F9K F;  3VJB A;  3KRO A;  3LGZ B;  4JVJ F;  3WCL A;  1V4K A;  1VG2 A;  5B0I A;  4F6X A;  3WCB A;  3LVS A;  4MC8 A;  2PS5 A;  1FPS A;  2OGD A;  4P0W A;  2ONH A;  3LLW A;  1WL2 A;  1UBW A;  5B00 A;  2E94 A;  3UCA A;  3WEH A;  3WCJ A;  4OMG A;  3WJK A;  4E1E A;  5IN8 A;  3WJO A;  2PS6 A;  4HD1 A;  3S4J A;  2PS4 A;  3Q30 A;  3SAE A;  2F8Z F;  5IL3 A;  1N1Z A;  3OAB A;  3TFN A;  3M00 A;  4XQT F;  2E93 A;  1V4H A;  3OAC B;  3P41 A;  2F89 F;  4EA0 A;  4QPF A;  4E9Z A;  4RXA A;  4RNQ A;  2OPM A;  2Q58 A;  2ZCS A;  5E8L A;  3LZ9 A;  2E8V A;  1V4J A;  1WY0 A;  5AFX A;  5B0L A;  4KQ5 A;  3NPR A;  2P1C A;  2Z4Z A;  2Z4Y A;  2Z7I A;  3RYE A;  5IK9 A;  3N45 F;  2Z4X A;  2E8U A;  1JFA A;  3AQB B;  1VG3 A;  4LA6 A;  3APZ A;  5AYP A;  2EWG A;  2PS8 A;  4F6V A;  3P8R A;  2J5C A;  3ICK A;  3WCA A;  5CG6 A;  5H9D A;  3ZL6 A;  3NRI A;  4OGU A;  5ERO A;  4LTV A;  5AHU B;  2ZCQ A;  3LJI A;  5ILK A;  5B03 A;  3VJ8 A;  4PVX F;  3CC9 A;  3LG5 A;  4KVY A;  4LLS A;  4XQR F;  3LSN A;  1YYQ A;  5ERN A;  3IPI A;  3OAB B;  3PDE A;  2ZCO A;  5DJV F;  4ZQ8 A;  5IMI A;  4NFK F;  3ACW A;  1KIY A;  1KIZ A;  2AEL A;  2J1P A;  4DEM F;  3PH7 A;  5DHI A;  3VJA A;  4DI5 A;  5JA0 F;  4LIX A;  2PS7 A;  4NUA A;  2F7M F;  4GP2 A;  1YHK A;  3V66 A;  5DGM F;  5DHK A;  3LOM A;  3SDQ A;  1VG7 A;  4RXE A;  3SDT A;  3ZMB A;  4KFA A;  3LEE A;  3KRP B;  1UBY A;  4GP1 A;  5EAT A;  4E9U A;  5E8H A;  2Q80 A;  3TFP A;  3KBK A;  5DZ2 A;  5JV0 F;  5ILH A;  2ZEU A;  4GAX A;  3P5P A;  4PVY F;  4LZ0 A;  1V4E A;  1YYS A;  3ID0 A;  1UBX A;  5B0J A;  1HXC A;  4NFI F;  3LGK A;  2OPN A;  3VJE A;  3WCE A;  1EZF A;  1HXG A;  2F92 F;  1YJ4 A;  3ADZ A;  2DH4 A;  4KK2 A;  1YQ7 A;  1HX9 A;  4LA5 A;  2E90 A;  4MC0 A;  3TFV A;  3DYF A;  3ACX A;  5IM1 A;  3LMD A;  2Q9Y A;  2AZL A;  1N23 A;  5B0K A;  4N1Z F;  3ICM A;  3ICZ A;  2ZEV A;  4KPD A;  2I19 A;  3N5J F;  4K10 A;  1RQI A;  3KRO B;  1ZW5 A;  3DYH A;  4RYP A;  4JYX A;  2AZK A;  5DGN F;  4NFJ F;  5HNA A;  3G4D A;  2QIS A;  1YYR A;  3WSB A;  4RXC A;  3RBM A;  3P5R A;  1VG4 A;  3RYW A;  3ZOU A;  3SDU A;  3WSA A;  4N9U A;  3SDR A;  3N5H F;  5ILD A;  2FTZ A;  5A0J A;  5CG5 A;  1N20 A;  3W7F A;  3KRA A;  4Q23 A;  4JXY A;  3VJC A;  5IVG A;  1HXA A;  3KRC A;  3B7L A;  3V1V A;  4LPH F;  4FP4 A;  3M01 A;  4NG6 A;  4LTZ A;  2F8C F;  3AQ0 A;  5AEL A;  2E92 A;  2J1O A;  2OA6 A;  3VJ9 A;  4KQS A;  3WEK A;  4LPG F;  4OMH A;  3WJN A;  4KWD A;  5JV1 F;  2Q9Z A;  4KVW A;  3Q2Q A;  4KVD A;  3RMG A;  3BNY A;  1HM7 A;  4QXS F;  3NPK A;  3Q1O A;  4H5D F;  3ZMC A;  4NKF A;  1YYU A;  2ZY1 A;  3WEJ A;  3IBA A;  1HM4 A;  4JXN A;  3TS7 A;  2FOR A;  3EFQ A;  4DWB A;  5IMN A; 
#chains in the Genus database with same CATH homology
 3QKC A;  2ONG A;  3AQC B;  3WCG A;  3PYA A;  5I1U A;  5JUZ F;  5ILY A;  5IKH A;  2AEK A;  4P0X A;  4NKE A;  5IK6 A;  2O1O A;  3NF2 A;  3N1W F;  4KUX A;  2E95 A;  3OYR A;  3CKE A;  5EAS A;  5ILI A;  2E8W A;  4JZX A;  3N0G A;  4KQU A;  4LFG A;  5DJR F;  2Z50 A;  4F62 A;  3DYG A;  4DXJ A;  4LOB A;  5IL8 A;  3TC1 A;  4LFE A;  1WMW A;  3LK5 A;  5KSX F;  5HN8 A;  5DW7 A;  5DGS F;  3EGT A;  3KRA B;  2Z4W A;  1DI1 A;  5ER8 A;  4FJQ A;  1N21 A;  5EAU A;  4L2X F;  4XQS F;  4EA1 A;  3KRC B;  3MAV A;  5HN9 A;  5B02 A;  3WCH A;  3PYB A;  5IK0 A;  3ASX A;  3KRF A;  5ILZ A;  1RQJ A;  5DIQ F;  3WCM A;  1VG6 A;  2H8O A;  2VF6 A;  3LDW A;  3Q2Z A;  2E4O A;  3M02 A;  3ACY A;  5C05 A;  2RAH A;  3N0F A;  3G4F A;  5IKA A;  3WC9 A;  3N6K F;  4LLT A;  5DJP F;  1DGP A;  4GA3 A;  1JFG A;  3QQV A;  3V1X A;  1WL1 A;  5JV2 F;  2ZCR A;  4OKZ A;  3MZV A;  1UBV A;  4OKM A;  4LUU A;  3ICN A;  1YHL A;  3P8L A;  3N3D A;  3EZ3 A;  1WL3 A;  3KB9 A;  1V4I A;  4LZ3 A;  3N49 F;  2E91 A;  3VJD A;  1N24 A;  2E8T A;  3PKO A;  4LZC A;  3BNX A;  4P0V A;  3KRP A;  3SDV A;  3CP6 A;  2Z7H A;  2AET A;  4EA2 A;  4WK5 A;  4DHD A;  3WCI A;  3WEG A;  3M0G A;  3ZCD A;  4KKM A;  4KPJ A;  2Z4V A;  2Z78 A;  4H5E F;  3KRF B;  4H5C F;  3N1V F;  4LFV F;  4KVI A;  2F94 F;  4DWG A;  1N1B A;  3M9U A;  1PS1 A;  4MC3 A;  1YV5 A;  3N3L F;  3WCD A;  5HN7 A;  5ERM A;  4JZB A;  3OAC A;  5ILJ A;  1WKZ A;  5E8K A;  5A0K A;  4UMJ A;  2E8X A;  3WEF A;  1N22 A;  1WL0 A;  5IMP A;  3AE0 A;  4DZW A;  5A0I A;  2Z52 A;  3S9V A;  5B0M A;  1RTR A;  5B01 A;  1YHM A;  3WEI A;  4LXW A;  1YYT A;  3N46 F;  3WCF A;  4RXD A;  2AZJ A;  3WE9 A;  3WCC A;  2F9K F;  3VJB A;  3KRO A;  3LGZ B;  4JVJ F;  3WCL A;  1V4K A;  1VG2 A;  5B0I A;  4F6X A;  3WCB A;  3LVS A;  4MC8 A;  2PS5 A;  1FPS A;  2OGD A;  4P0W A;  2ONH A;  3LLW A;  1WL2 A;  1UBW A;  5B00 A;  2E94 A;  3UCA A;  3WEH A;  3WCJ A;  4OMG A;  3WJK A;  4E1E A;  5IN8 A;  3WJO A;  2PS6 A;  4HD1 A;  3S4J A;  2PS4 A;  3Q30 A;  3SAE A;  2F8Z F;  5IL3 A;  1N1Z A;  3OAB A;  3TFN A;  3M00 A;  4XQT F;  2E93 A;  1V4H A;  3OAC B;  3P41 A;  2F89 F;  4EA0 A;  4QPF A;  4E9Z A;  4RXA A;  4RNQ A;  2OPM A;  2Q58 A;  2ZCS A;  5E8L A;  3LZ9 A;  2E8V A;  1V4J A;  1WY0 A;  5AFX A;  5B0L A;  4KQ5 A;  3NPR A;  2P1C A;  2Z4Z A;  2Z4Y A;  2Z7I A;  3RYE A;  5IK9 A;  3N45 F;  2Z4X A;  2E8U A;  1JFA A;  3AQB B;  1VG3 A;  4LA6 A;  3APZ A;  5AYP A;  2EWG A;  2PS8 A;  4F6V A;  3P8R A;  2J5C A;  3ICK A;  3WCA A;  5CG6 A;  5H9D A;  3ZL6 A;  3NRI A;  4OGU A;  5ERO A;  4LTV A;  5AHU B;  2ZCQ A;  3LJI A;  5ILK A;  5B03 A;  3VJ8 A;  4PVX F;  3CC9 A;  3LG5 A;  4KVY A;  4LLS A;  4XQR F;  3LSN A;  1YYQ A;  5ERN A;  3IPI A;  3OAB B;  3PDE A;  2ZCO A;  5DJV F;  4ZQ8 A;  5IMI A;  4NFK F;  3ACW A;  1KIY A;  1KIZ A;  2AEL A;  2J1P A;  4DEM F;  3PH7 A;  5DHI A;  3VJA A;  4DI5 A;  5JA0 F;  4LIX A;  2PS7 A;  4NUA A;  2F7M F;  4GP2 A;  1YHK A;  3V66 A;  5DGM F;  5DHK A;  3LOM A;  3SDQ A;  1VG7 A;  4RXE A;  3SDT A;  3ZMB A;  4KFA A;  3LEE A;  3KRP B;  1UBY A;  4GP1 A;  5EAT A;  4E9U A;  5E8H A;  2Q80 A;  3TFP A;  3KBK A;  5DZ2 A;  5JV0 F;  5ILH A;  2ZEU A;  4GAX A;  3P5P A;  4PVY F;  4LZ0 A;  1V4E A;  1YYS A;  3ID0 A;  1UBX A;  5B0J A;  1HXC A;  4NFI F;  3LGK A;  2OPN A;  3VJE A;  3WCE A;  1EZF A;  1HXG A;  2F92 F;  1YJ4 A;  3ADZ A;  2DH4 A;  4KK2 A;  1YQ7 A;  1HX9 A;  4LA5 A;  2E90 A;  4MC0 A;  3TFV A;  3DYF A;  3ACX A;  5IM1 A;  3LMD A;  2Q9Y A;  2AZL A;  1N23 A;  5B0K A;  4N1Z F;  3ICM A;  3ICZ A;  2ZEV A;  4KPD A;  2I19 A;  3N5J F;  4K10 A;  1RQI A;  3KRO B;  1ZW5 A;  3DYH A;  4RYP A;  4JYX A;  2AZK A;  5DGN F;  4NFJ F;  5HNA A;  3G4D A;  2QIS A;  1YYR A;  3WSB A;  4RXC A;  3RBM A;  3P5R A;  1VG4 A;  3RYW A;  3ZOU A;  3SDU A;  3WSA A;  4N9U A;  3SDR A;  3N5H F;  5ILD A;  2FTZ A;  5A0J A;  5CG5 A;  1N20 A;  3W7F A;  3KRA A;  4Q23 A;  4JXY A;  3VJC A;  5IVG A;  1HXA A;  3KRC A;  3B7L A;  3V1V A;  4LPH F;  4FP4 A;  3M01 A;  4NG6 A;  4LTZ A;  2F8C F;  3AQ0 A;  5AEL A;  2E92 A;  2J1O A;  2OA6 A;  3VJ9 A;  4KQS A;  3WEK A;  4LPG F;  4OMH A;  3WJN A;  4KWD A;  5JV1 F;  2Q9Z A;  4KVW A;  3Q2Q A;  4KVD A;  3RMG A;  3BNY A;  1HM7 A;  4QXS F;  3NPK A;  3Q1O A;  4H5D F;  3ZMC A;  4NKF A;  1YYU A;  2ZY1 A;  3WEJ A;  3IBA A;  1HM4 A;  4JXN A;  3TS7 A;  2FOR A;  3EFQ A;  4DWB A;  5IMN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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