4NG6A

The effects of lysine 200 and phenylalanine 239 farnesyl pyrophosphate synthase (fpps) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
344
structure length
344
Chain Sequence
YAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYLTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Farnesyl pyrophosphate synthase
total genus 131
structure length 344
sequence length 344
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2013-11-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4ng6A00
4NUAA 3B7LA 4E9ZA 3CC9A 1YYRA 3OABA 4PVXF 5EROA 5B0LA 3LOMA 5ER8A 4OMHA 3WEIA 3M01A 5IMPA 3V66A 1V4HA 2I19A 5IKAA 5ILIA 2F8ZF 3SDVA 1YV5A 3BNXA 4LPGF 4LLSA 3Q30A 2Z4WA 2RAHA 5HN7A 4N9UA 3PYBA 4LFVF 3WEGA 4FJQA 5EASA 3N5JF 3M0GA 5IMNA 2ZY1A 4ZQ8A 3RBMA 3WEFA 1WY0A 2Q9ZA 1N1BA 3AQCB 3LK5A 3WCAA 3NF2A 3WE9A 2H8OA 4PVYF 4DI5A 5B0KA 3N0GA 3ICMA 5ILHA 5JV0F 3WCBA 1WL0A 4KQ5A 3G4DA 3WCEA 4KVDA 4XQTF 2ONGA 4F6XA 4MC3A 3M00A 2ONHA 4KPDA 4LA6A 4E9UA 3N1WF 3KRAB 3N46F 5IMIA 1PS1A 3ACXA 3NPRA 3S9VA 4EA0A 3P5RA 3P8LA 3DYGA 2F7MF 5DHKA 5B0IA 2ZCRA 4QPFA 2PS5A 3N0FA 3WCGA 1V4JA 5ILZA 2AELA 3LGZB 3LMDA 5EATA 1HXAA 3P5PA 3TC1A 2ZCSA 3Q2ZA 3PKOA 5C05A 4DXJA 3WJKA 1HXGA 3VJAA 1RQIA 5EAUA 5IL3A 2Z4YA 3KRCA 4JXYA 4NFIF 1VG6A 3OACB 4OKZA 2OGDA 3KRFB 3RMGA 2Z78A 3ICNA 4P0WA 5B02A 4GP1A 2F94F 2F92F 3ICKA 2E91A 4F62A 4NFKF 4E1EA 3IPIA 3SDRA 1EZFA 3WEHA 2OPNA 5H9DA 5ILYA 3NRIA 3OACA 5JV2F 3P8RA 2ZCQA 4NG6A 5DGMF 1WMWA 4LXWA 3WCMA 3LG5A 4JVJF 5E8LA 3G4FA 3EGTA 2E8UA 4LA5A 3TS7A 4OMGA 3VJDA 5IN8A 4EA1A 4LZ3A 3PYAA 2OPMA 3WCLA 1YQ7A 2E4OA 3M02A 2OA6A 3ICZA 3SDQA 5DIQF 4H5CF 4F6VA 1DI1A 2AZKA 4DZWA 1YYSA 2PS6A 4LZ0A 3TFNA 3DYFA 3S4JA 3P41A 2F8CF 1YHKA 3WEJA 3MAVA 3N45F 2QISA 2Q58A 2Q80A 5IK0A 1VG3A 2F89F 4LTVA 5A0IA 5B01A 2Z4XA 4DHDA 5ILKA 5IKHA 3ACWA 3WSAA 2DH4A 3KRPB 2Q9YA 3BNYA 1KIZA 2J1OA 5DZ2A 2E92A 3N3DA 4GA3A 5CG5A 3ZMCA 5B00A 3KRPA 3W7FA 4UMJA 5ILDA 3WSBA 1YHLA 3DYHA 4RNQA 1UBWA 1WL3A 3WCFA 5DJPF 3WC9A 4LIXA 3KRCB 1WL2A 2Z7IA 4NFJF 4RXAA 1V4EA 5HN9A 2PS8A 3WCCA 3LJIA 3PH7A 1VG2A 3ASXA 5DJRF 3VJBA 3LZ9A 1HX9A 2J5CA 5B0JA 3ID0A 4LLTA 1WKZA 1ZW5A 1DGPA 4LPHF 4HD1A 3WCDA 3Q1OA 5E8HA 4KVIA 5AYPA 3KBKA 4XQSF 2E93A 3N6KF 1UBXA 1YYUA 1VG4A 3PDEA 2AEKA 3CP6A 2PS7A 2AZJA 4N1ZF 4KFAA 2E94A 3APZA 3N3LF 4OKMA 2O1OA 4MC0A 4XQRF 4K10A 1YJ4A 4KQUA 2E8XA 3WJNA 2E8VA 1HM7A 5AHUB 4QXSF 4DWGA 1VG7A 1N1ZA 1N21A 3ACYA 4FP4A 1YYQA 2Z50A 2E8TA 3EZ3A 3QQVA 3RYEA 4DWBA 3EFQA 3LDWA 4JZXA 2Z4ZA 3KB9A 5IK9A 3QKCA 5IM1A 5ILJA 1UBYA 2E95A 3KROB 4DEMF 3WCIA 4LTZA 3OYRA 3V1VA 5A0KA 3WCJA 1YYTA 4WK5A 3AQBB 3MZVA 2PS4A 4KQSA 5AFXA 4LFGA 2AETA 4EA2A 4P0XA 5KSXF 3V1XA 5B03A 1UBVA 2Z52A 3KROA 3N1VF 4RXDA 5HN8A 5IK6A 4GP2A 4RXEA 5DW7A 3Q2QA 3VJ9A 1N22A 2ZEVA 5B0MA 3SDUA 1V4KA 5DGSF 3CKEA 2E8WA 3WEKA 3WJOA 5ERNA 5CG6A 3LEEA 1JFGA 1RQJA 3VJ8A 5ERMA 5JV1F 2F9KF 1FPSA 4KVYA 4L2XF 4RXCA 5E8KA 5I1UA 3LSNA 4KWDA 2ZEUA 3TFPA 2AZLA 4GAXA 3SAEA 4KVWA 2ZCOA 3ZL6A 2Z4VA 3IBAA 4RYPA 3ZOUA 4JXNA 1RTRA 4Q23A 4LZCA 2FORA 1N20A 4LOBA 3KRAA 1HXCA 5A0JA 3M9UA 3NPKA 4JZBA 4JYXA 4NKEA 3SDTA 3AE0A 1WL1A 2P1CA 3ZMBA 5DGNF 4KUXA 4OGUA 3AQ0A 3ZCDA 4KK2A 5IL8A 2Z7HA 1KIYA 3N5HF 3VJEA 3LGKA 3ADZA 3UCAA 2VF6A 5HNAA 1HM4A 2E90A 1N23A 3VJCA 1YHMA 3TFVA 3LVSA 3WCHA 1N24A 4LUUA 5JUZF 3N49F 2J1PA 4LFEA 3RYWA 3OABB 5IVGA 1JFAA 4KKMA 4MC8A 5DJVF 3KRFA 4H5EF 5DHIA 4H5DF 4P0VA 4KPJA 3LLWA 5JA0F 5AELA 2EWGA 1V4IA 2FTZA 4NKFA
chains in the Genus database with same CATH superfamily
4NUAA 3B7LA 4E9ZA 3CC9A 1YYRA 3OABA 4PVXF 5EROA 5B0LA 3LOMA 5ER8A 4OMHA 3WEIA 3M01A 5IMPA 3V66A 1V4HA 2I19A 5IKAA 5ILIA 2F8ZF 3SDVA 1YV5A 3BNXA 4LPGF 4LLSA 3Q30A 2Z4WA 2RAHA 5HN7A 4N9UA 3PYBA 4LFVF 3WEGA 4FJQA 5EASA 3N5JF 3M0GA 5IMNA 2ZY1A 4ZQ8A 3RBMA 3WEFA 1WY0A 2Q9ZA 1N1BA 3AQCB 3LK5A 3WCAA 3NF2A 3WE9A 2H8OA 4PVYF 4DI5A 5B0KA 3N0GA 3ICMA 5ILHA 5JV0F 3WCBA 1WL0A 4KQ5A 3G4DA 3WCEA 4KVDA 4XQTF 2ONGA 4F6XA 4MC3A 3M00A 2ONHA 4KPDA 4LA6A 4E9UA 3N1WF 3KRAB 3N46F 5IMIA 1PS1A 3ACXA 3NPRA 3S9VA 4EA0A 3P5RA 3P8LA 3DYGA 2F7MF 5DHKA 5B0IA 2ZCRA 4QPFA 2PS5A 3N0FA 3WCGA 1V4JA 5ILZA 2AELA 3LGZB 3LMDA 5EATA 1HXAA 3P5PA 3TC1A 2ZCSA 3Q2ZA 3PKOA 5C05A 4DXJA 3WJKA 1HXGA 3VJAA 1RQIA 5EAUA 5IL3A 2Z4YA 3KRCA 4JXYA 4NFIF 1VG6A 3OACB 4OKZA 2OGDA 3KRFB 3RMGA 2Z78A 3ICNA 4P0WA 5B02A 4GP1A 2F94F 2F92F 3ICKA 2E91A 4F62A 4NFKF 4E1EA 3IPIA 3SDRA 1EZFA 3WEHA 2OPNA 5H9DA 5ILYA 3NRIA 3OACA 5JV2F 3P8RA 2ZCQA 4NG6A 5DGMF 1WMWA 4LXWA 3WCMA 3LG5A 4JVJF 5E8LA 3G4FA 3EGTA 2E8UA 4LA5A 3TS7A 4OMGA 3VJDA 5IN8A 4EA1A 4LZ3A 3PYAA 2OPMA 3WCLA 1YQ7A 2E4OA 3M02A 2OA6A 3ICZA 3SDQA 5DIQF 4H5CF 4F6VA 1DI1A 2AZKA 4DZWA 1YYSA 2PS6A 4LZ0A 3TFNA 3DYFA 3S4JA 3P41A 2F8CF 1YHKA 3WEJA 3MAVA 3N45F 2QISA 2Q58A 2Q80A 5IK0A 1VG3A 2F89F 4LTVA 5A0IA 5B01A 2Z4XA 4DHDA 5ILKA 5IKHA 3ACWA 3WSAA 2DH4A 3KRPB 2Q9YA 3BNYA 1KIZA 2J1OA 5DZ2A 2E92A 3N3DA 4GA3A 5CG5A 3ZMCA 5B00A 3KRPA 3W7FA 4UMJA 5ILDA 3WSBA 1YHLA 3DYHA 4RNQA 1UBWA 1WL3A 3WCFA 5DJPF 3WC9A 4LIXA 3KRCB 1WL2A 2Z7IA 4NFJF 4RXAA 1V4EA 5HN9A 2PS8A 3WCCA 3LJIA 3PH7A 1VG2A 3ASXA 5DJRF 3VJBA 3LZ9A 1HX9A 2J5CA 5B0JA 3ID0A 4LLTA 1WKZA 1ZW5A 1DGPA 4LPHF 4HD1A 3WCDA 3Q1OA 5E8HA 4KVIA 5AYPA 3KBKA 4XQSF 2E93A 3N6KF 1UBXA 1YYUA 1VG4A 3PDEA 2AEKA 3CP6A 2PS7A 2AZJA 4N1ZF 4KFAA 2E94A 3APZA 3N3LF 4OKMA 2O1OA 4MC0A 4XQRF 4K10A 1YJ4A 4KQUA 2E8XA 3WJNA 2E8VA 1HM7A 5AHUB 4QXSF 4DWGA 1VG7A 1N1ZA 1N21A 3ACYA 4FP4A 1YYQA 2Z50A 2E8TA 3EZ3A 3QQVA 3RYEA 4DWBA 3EFQA 3LDWA 4JZXA 2Z4ZA 3KB9A 5IK9A 3QKCA 5IM1A 5ILJA 1UBYA 2E95A 3KROB 4DEMF 3WCIA 4LTZA 3OYRA 3V1VA 5A0KA 3WCJA 1YYTA 4WK5A 3AQBB 3MZVA 2PS4A 4KQSA 5AFXA 4LFGA 2AETA 4EA2A 4P0XA 5KSXF 3V1XA 5B03A 1UBVA 2Z52A 3KROA 3N1VF 4RXDA 5HN8A 5IK6A 4GP2A 4RXEA 5DW7A 3Q2QA 3VJ9A 1N22A 2ZEVA 5B0MA 3SDUA 1V4KA 5DGSF 3CKEA 2E8WA 3WEKA 3WJOA 5ERNA 5CG6A 3LEEA 1JFGA 1RQJA 3VJ8A 5ERMA 5JV1F 2F9KF 1FPSA 4KVYA 4L2XF 4RXCA 5E8KA 5I1UA 3LSNA 4KWDA 2ZEUA 3TFPA 2AZLA 4GAXA 3SAEA 4KVWA 2ZCOA 3ZL6A 2Z4VA 3IBAA 4RYPA 3ZOUA 4JXNA 1RTRA 4Q23A 4LZCA 2FORA 1N20A 4LOBA 3KRAA 1HXCA 5A0JA 3M9UA 3NPKA 4JZBA 4JYXA 4NKEA 3SDTA 3AE0A 1WL1A 2P1CA 3ZMBA 5DGNF 4KUXA 4OGUA 3AQ0A 3ZCDA 4KK2A 5IL8A 2Z7HA 1KIYA 3N5HF 3VJEA 3LGKA 3ADZA 3UCAA 2VF6A 5HNAA 1HM4A 2E90A 1N23A 3VJCA 1YHMA 3TFVA 3LVSA 3WCHA 1N24A 4LUUA 5JUZF 3N49F 2J1PA 4LFEA 3RYWA 3OABB 5IVGA 1JFAA 4KKMA 4MC8A 5DJVF 3KRFA 4H5EF 5DHIA 4H5DF 4P0VA 4KPJA 3LLWA 5JA0F 5AELA 2EWGA 1V4IA 2FTZA 4NKFA
chains in the Genus database with same CATH topology
4NUAA 3B7LA 4E9ZA 3CC9A 1YYRA 3OABA 4PVXF 5EROA 5B0LA 3LOMA 5ER8A 4OMHA 3WEIA 3M01A 5IMPA 3V66A 1V4HA 2I19A 5IKAA 5ILIA 2F8ZF 3SDVA 1YV5A 3BNXA 4LPGF 4LLSA 3Q30A 2Z4WA 2RAHA 5HN7A 4N9UA 3PYBA 4LFVF 3WEGA 4FJQA 5EASA 3N5JF 3M0GA 5IMNA 2ZY1A 4ZQ8A 3RBMA 3WEFA 1WY0A 2Q9ZA 1N1BA 3AQCB 3LK5A 3WCAA 3NF2A 3WE9A 2H8OA 4PVYF 4DI5A 5B0KA 3N0GA 3ICMA 5ILHA 5JV0F 3WCBA 1WL0A 4KQ5A 3G4DA 3WCEA 4KVDA 4XQTF 2ONGA 4F6XA 4MC3A 3M00A 2ONHA 4KPDA 4LA6A 4E9UA 3N1WF 3KRAB 3N46F 5IMIA 1PS1A 3ACXA 3NPRA 3S9VA 4EA0A 3P5RA 3P8LA 3DYGA 2F7MF 5DHKA 5B0IA 2ZCRA 4QPFA 2PS5A 3N0FA 3WCGA 1V4JA 5ILZA 2AELA 3LGZB 3LMDA 5EATA 1HXAA 3P5PA 3TC1A 2ZCSA 3Q2ZA 3PKOA 5C05A 4DXJA 3WJKA 1HXGA 3VJAA 1RQIA 5EAUA 5IL3A 2Z4YA 3KRCA 4JXYA 4NFIF 1VG6A 3OACB 4OKZA 2OGDA 3KRFB 3RMGA 2Z78A 3ICNA 4P0WA 5B02A 4GP1A 2F94F 2F92F 3ICKA 2E91A 4F62A 4NFKF 4E1EA 3IPIA 3SDRA 1EZFA 3WEHA 2OPNA 5H9DA 5ILYA 3NRIA 3OACA 5JV2F 3P8RA 2ZCQA 4NG6A 5DGMF 1WMWA 4LXWA 3WCMA 3LG5A 4JVJF 5E8LA 3G4FA 3EGTA 2E8UA 4LA5A 3TS7A 4OMGA 3VJDA 5IN8A 4EA1A 4LZ3A 3PYAA 2OPMA 3WCLA 1YQ7A 2E4OA 3M02A 2OA6A 3ICZA 3SDQA 5DIQF 4H5CF 4F6VA 1DI1A 2AZKA 4DZWA 1YYSA 2PS6A 4LZ0A 3TFNA 3DYFA 3S4JA 3P41A 2F8CF 1YHKA 3WEJA 3MAVA 3N45F 2QISA 2Q58A 2Q80A 5IK0A 1VG3A 2F89F 4LTVA 5A0IA 5B01A 2Z4XA 4DHDA 5ILKA 5IKHA 3ACWA 3WSAA 2DH4A 3KRPB 2Q9YA 3BNYA 1KIZA 2J1OA 5DZ2A 2E92A 3N3DA 4GA3A 5CG5A 3ZMCA 5B00A 3KRPA 3W7FA 4UMJA 5ILDA 3WSBA 1YHLA 3DYHA 4RNQA 1UBWA 1WL3A 3WCFA 5DJPF 3WC9A 4LIXA 3KRCB 1WL2A 2Z7IA 4NFJF 4RXAA 1V4EA 5HN9A 2PS8A 3WCCA 3LJIA 3PH7A 1VG2A 3ASXA 5DJRF 3VJBA 3LZ9A 1HX9A 2J5CA 5B0JA 3ID0A 4LLTA 1WKZA 1ZW5A 1DGPA 4LPHF 4HD1A 3WCDA 3Q1OA 5E8HA 4KVIA 5AYPA 3KBKA 4XQSF 2E93A 3N6KF 1UBXA 1YYUA 1VG4A 3PDEA 2AEKA 3CP6A 2PS7A 2AZJA 4N1ZF 4KFAA 2E94A 3APZA 3N3LF 4OKMA 2O1OA 4MC0A 4XQRF 4K10A 1YJ4A 4KQUA 2E8XA 3WJNA 2E8VA 1HM7A 5AHUB 4QXSF 4DWGA 1VG7A 1N1ZA 1N21A 3ACYA 4FP4A 1YYQA 2Z50A 2E8TA 3EZ3A 3QQVA 3RYEA 4DWBA 3EFQA 3LDWA 4JZXA 2Z4ZA 3KB9A 5IK9A 3QKCA 5IM1A 5ILJA 1UBYA 2E95A 3KROB 4DEMF 3WCIA 4LTZA 3OYRA 3V1VA 5A0KA 3WCJA 1YYTA 4WK5A 3AQBB 3MZVA 2PS4A 4KQSA 5AFXA 4LFGA 2AETA 4EA2A 4P0XA 5KSXF 3V1XA 5B03A 1UBVA 2Z52A 3KROA 3N1VF 4RXDA 5HN8A 5IK6A 4GP2A 4RXEA 5DW7A 3Q2QA 3VJ9A 1N22A 2ZEVA 5B0MA 3SDUA 1V4KA 5DGSF 3CKEA 2E8WA 3WEKA 3WJOA 5ERNA 5CG6A 3LEEA 1JFGA 1RQJA 3VJ8A 5ERMA 5JV1F 2F9KF 1FPSA 4KVYA 4L2XF 4RXCA 5E8KA 5I1UA 3LSNA 4KWDA 2ZEUA 3TFPA 2AZLA 4GAXA 3SAEA 4KVWA 2ZCOA 3ZL6A 2Z4VA 3IBAA 4RYPA 3ZOUA 4JXNA 1RTRA 4Q23A 4LZCA 2FORA 1N20A 4LOBA 3KRAA 1HXCA 5A0JA 3M9UA 3NPKA 4JZBA 4JYXA 4NKEA 3SDTA 3AE0A 1WL1A 2P1CA 3ZMBA 5DGNF 4KUXA 4OGUA 3AQ0A 3ZCDA 4KK2A 5IL8A 2Z7HA 1KIYA 3N5HF 3VJEA 3LGKA 3ADZA 3UCAA 2VF6A 5HNAA 1HM4A 2E90A 1N23A 3VJCA 1YHMA 3TFVA 3LVSA 3WCHA 1N24A 4LUUA 5JUZF 3N49F 2J1PA 4LFEA 3RYWA 3OABB 5IVGA 1JFAA 4KKMA 4MC8A 5DJVF 3KRFA 4H5EF 5DHIA 4H5DF 4P0VA 4KPJA 3LLWA 5JA0F 5AELA 2EWGA 1V4IA 2FTZA 4NKFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NUA A;  3B7L A;  4E9Z A;  3CC9 A;  1YYR A;  3OAB A;  4PVX F;  5ERO A;  5B0L A;  3LOM A;  5ER8 A;  4OMH A;  3WEI A;  3M01 A;  5IMP A;  3V66 A;  1V4H A;  2I19 A;  5IKA A;  5ILI A;  2F8Z F;  3SDV A;  1YV5 A;  3BNX A;  4LPG F;  4LLS A;  3Q30 A;  2Z4W A;  2RAH A;  5HN7 A;  4N9U A;  3PYB A;  4LFV F;  3WEG A;  4FJQ A;  5EAS A;  3N5J F;  3M0G A;  5IMN A;  2ZY1 A;  4ZQ8 A;  3RBM A;  3WEF A;  1WY0 A;  2Q9Z A;  1N1B A;  3AQC B;  3LK5 A;  3WCA A;  3NF2 A;  3WE9 A;  2H8O A;  4PVY F;  4DI5 A;  5B0K A;  3N0G A;  3ICM A;  5ILH A;  5JV0 F;  3WCB A;  1WL0 A;  4KQ5 A;  3G4D A;  3WCE A;  4KVD A;  4XQT F;  2ONG A;  4F6X A;  4MC3 A;  3M00 A;  2ONH A;  4KPD A;  4LA6 A;  4E9U A;  3N1W F;  3KRA B;  3N46 F;  5IMI A;  1PS1 A;  3ACX A;  3NPR A;  3S9V A;  4EA0 A;  3P5R A;  3P8L A;  3DYG A;  2F7M F;  5DHK A;  5B0I A;  2ZCR A;  4QPF A;  2PS5 A;  3N0F A;  3WCG A;  1V4J A;  5ILZ A;  2AEL A;  3LGZ B;  3LMD A;  5EAT A;  1HXA A;  3P5P A;  3TC1 A;  2ZCS A;  3Q2Z A;  3PKO A;  5C05 A;  4DXJ A;  3WJK A;  1HXG A;  3VJA A;  1RQI A;  5EAU A;  5IL3 A;  2Z4Y A;  3KRC A;  4JXY A;  4NFI F;  1VG6 A;  3OAC B;  4OKZ A;  2OGD A;  3KRF B;  3RMG A;  2Z78 A;  3ICN A;  4P0W A;  5B02 A;  4GP1 A;  2F94 F;  2F92 F;  3ICK A;  2E91 A;  4F62 A;  4NFK F;  4E1E A;  3IPI A;  3SDR A;  1EZF A;  3WEH A;  2OPN A;  5H9D A;  5ILY A;  3NRI A;  3OAC A;  5JV2 F;  3P8R A;  2ZCQ A;  4NG6 A;  5DGM F;  1WMW A;  4LXW A;  3WCM A;  3LG5 A;  4JVJ F;  5E8L A;  3G4F A;  3EGT A;  2E8U A;  4LA5 A;  3TS7 A;  4OMG A;  3VJD A;  5IN8 A;  4EA1 A;  4LZ3 A;  3PYA A;  2OPM A;  3WCL A;  1YQ7 A;  2E4O A;  3M02 A;  2OA6 A;  3ICZ A;  3SDQ A;  5DIQ F;  4H5C F;  4F6V A;  1DI1 A;  2AZK A;  4DZW A;  1YYS A;  2PS6 A;  4LZ0 A;  3TFN A;  3DYF A;  3S4J A;  3P41 A;  2F8C F;  1YHK A;  3WEJ A;  3MAV A;  3N45 F;  2QIS A;  2Q58 A;  2Q80 A;  5IK0 A;  1VG3 A;  2F89 F;  4LTV A;  5A0I A;  5B01 A;  2Z4X A;  4DHD A;  5ILK A;  5IKH A;  3ACW A;  3WSA A;  2DH4 A;  3KRP B;  2Q9Y A;  3BNY A;  1KIZ A;  2J1O A;  5DZ2 A;  2E92 A;  3N3D A;  4GA3 A;  5CG5 A;  3ZMC A;  5B00 A;  3KRP A;  3W7F A;  4UMJ A;  5ILD A;  3WSB A;  1YHL A;  3DYH A;  4RNQ A;  1UBW A;  1WL3 A;  3WCF A;  5DJP F;  3WC9 A;  4LIX A;  3KRC B;  1WL2 A;  2Z7I A;  4NFJ F;  4RXA A;  1V4E A;  5HN9 A;  2PS8 A;  3WCC A;  3LJI A;  3PH7 A;  1VG2 A;  3ASX A;  5DJR F;  3VJB A;  3LZ9 A;  1HX9 A;  2J5C A;  5B0J A;  3ID0 A;  4LLT A;  1WKZ A;  1ZW5 A;  1DGP A;  4LPH F;  4HD1 A;  3WCD A;  3Q1O A;  5E8H A;  4KVI A;  5AYP A;  3KBK A;  4XQS F;  2E93 A;  3N6K F;  1UBX A;  1YYU A;  1VG4 A;  3PDE A;  2AEK A;  3CP6 A;  2PS7 A;  2AZJ A;  4N1Z F;  4KFA A;  2E94 A;  3APZ A;  3N3L F;  4OKM A;  2O1O A;  4MC0 A;  4XQR F;  4K10 A;  1YJ4 A;  4KQU A;  2E8X A;  3WJN A;  2E8V A;  1HM7 A;  5AHU B;  4QXS F;  4DWG A;  1VG7 A;  1N1Z A;  1N21 A;  3ACY A;  4FP4 A;  1YYQ A;  2Z50 A;  2E8T A;  3EZ3 A;  3QQV A;  3RYE A;  4DWB A;  3EFQ A;  3LDW A;  4JZX A;  2Z4Z A;  3KB9 A;  5IK9 A;  3QKC A;  5IM1 A;  5ILJ A;  1UBY A;  2E95 A;  3KRO B;  4DEM F;  3WCI A;  4LTZ A;  3OYR A;  3V1V A;  5A0K A;  3WCJ A;  1YYT A;  4WK5 A;  3AQB B;  3MZV A;  2PS4 A;  4KQS A;  5AFX A;  4LFG A;  2AET A;  4EA2 A;  4P0X A;  5KSX F;  3V1X A;  5B03 A;  1UBV A;  2Z52 A;  3KRO A;  3N1V F;  4RXD A;  5HN8 A;  5IK6 A;  4GP2 A;  4RXE A;  5DW7 A;  3Q2Q A;  3VJ9 A;  1N22 A;  2ZEV A;  5B0M A;  3SDU A;  1V4K A;  5DGS F;  3CKE A;  2E8W A;  3WEK A;  3WJO A;  5ERN A;  5CG6 A;  3LEE A;  1JFG A;  1RQJ A;  3VJ8 A;  5ERM A;  5JV1 F;  2F9K F;  1FPS A;  4KVY A;  4L2X F;  4RXC A;  5E8K A;  5I1U A;  3LSN A;  4KWD A;  2ZEU A;  3TFP A;  2AZL A;  4GAX A;  3SAE A;  4KVW A;  2ZCO A;  3ZL6 A;  2Z4V A;  3IBA A;  4RYP A;  3ZOU A;  4JXN A;  1RTR A;  4Q23 A;  4LZC A;  2FOR A;  1N20 A;  4LOB A;  3KRA A;  1HXC A;  5A0J A;  3M9U A;  3NPK A;  4JZB A;  4JYX A;  4NKE A;  3SDT A;  3AE0 A;  1WL1 A;  2P1C A;  3ZMB A;  5DGN F;  4KUX A;  4OGU A;  3AQ0 A;  3ZCD A;  4KK2 A;  5IL8 A;  2Z7H A;  1KIY A;  3N5H F;  3VJE A;  3LGK A;  3ADZ A;  3UCA A;  2VF6 A;  5HNA A;  1HM4 A;  2E90 A;  1N23 A;  3VJC A;  1YHM A;  3TFV A;  3LVS A;  3WCH A;  1N24 A;  4LUU A;  5JUZ F;  3N49 F;  2J1P A;  4LFE A;  3RYW A;  3OAB B;  5IVG A;  1JFA A;  4KKM A;  4MC8 A;  5DJV F;  3KRF A;  4H5E F;  5DHI A;  4H5D F;  4P0V A;  4KPJ A;  3LLW A;  5JA0 F;  5AEL A;  2EWG A;  1V4I A;  2FTZ A;  4NKF A; 
#chains in the Genus database with same CATH topology
 4NUA A;  3B7L A;  4E9Z A;  3CC9 A;  1YYR A;  3OAB A;  4PVX F;  5ERO A;  5B0L A;  3LOM A;  5ER8 A;  4OMH A;  3WEI A;  3M01 A;  5IMP A;  3V66 A;  1V4H A;  2I19 A;  5IKA A;  5ILI A;  2F8Z F;  3SDV A;  1YV5 A;  3BNX A;  4LPG F;  4LLS A;  3Q30 A;  2Z4W A;  2RAH A;  5HN7 A;  4N9U A;  3PYB A;  4LFV F;  3WEG A;  4FJQ A;  5EAS A;  3N5J F;  3M0G A;  5IMN A;  2ZY1 A;  4ZQ8 A;  3RBM A;  3WEF A;  1WY0 A;  2Q9Z A;  1N1B A;  3AQC B;  3LK5 A;  3WCA A;  3NF2 A;  3WE9 A;  2H8O A;  4PVY F;  4DI5 A;  5B0K A;  3N0G A;  3ICM A;  5ILH A;  5JV0 F;  3WCB A;  1WL0 A;  4KQ5 A;  3G4D A;  3WCE A;  4KVD A;  4XQT F;  2ONG A;  4F6X A;  4MC3 A;  3M00 A;  2ONH A;  4KPD A;  4LA6 A;  4E9U A;  3N1W F;  3KRA B;  3N46 F;  5IMI A;  1PS1 A;  3ACX A;  3NPR A;  3S9V A;  4EA0 A;  3P5R A;  3P8L A;  3DYG A;  2F7M F;  5DHK A;  5B0I A;  2ZCR A;  4QPF A;  2PS5 A;  3N0F A;  3WCG A;  1V4J A;  5ILZ A;  2AEL A;  3LGZ B;  3LMD A;  5EAT A;  1HXA A;  3P5P A;  3TC1 A;  2ZCS A;  3Q2Z A;  3PKO A;  5C05 A;  4DXJ A;  3WJK A;  1HXG A;  3VJA A;  1RQI A;  5EAU A;  5IL3 A;  2Z4Y A;  3KRC A;  4JXY A;  4NFI F;  1VG6 A;  3OAC B;  4OKZ A;  2OGD A;  3KRF B;  3RMG A;  2Z78 A;  3ICN A;  4P0W A;  5B02 A;  4GP1 A;  2F94 F;  2F92 F;  3ICK A;  2E91 A;  4F62 A;  4NFK F;  4E1E A;  3IPI A;  3SDR A;  1EZF A;  3WEH A;  2OPN A;  5H9D A;  5ILY A;  3NRI A;  3OAC A;  5JV2 F;  3P8R A;  2ZCQ A;  4NG6 A;  5DGM F;  1WMW A;  4LXW A;  3WCM A;  3LG5 A;  4JVJ F;  5E8L A;  3G4F A;  3EGT A;  2E8U A;  4LA5 A;  3TS7 A;  4OMG A;  3VJD A;  5IN8 A;  4EA1 A;  4LZ3 A;  3PYA A;  2OPM A;  3WCL A;  1YQ7 A;  2E4O A;  3M02 A;  2OA6 A;  3ICZ A;  3SDQ A;  5DIQ F;  4H5C F;  4F6V A;  1DI1 A;  2AZK A;  4DZW A;  1YYS A;  2PS6 A;  4LZ0 A;  3TFN A;  3DYF A;  3S4J A;  3P41 A;  2F8C F;  1YHK A;  3WEJ A;  3MAV A;  3N45 F;  2QIS A;  2Q58 A;  2Q80 A;  5IK0 A;  1VG3 A;  2F89 F;  4LTV A;  5A0I A;  5B01 A;  2Z4X A;  4DHD A;  5ILK A;  5IKH A;  3ACW A;  3WSA A;  2DH4 A;  3KRP B;  2Q9Y A;  3BNY A;  1KIZ A;  2J1O A;  5DZ2 A;  2E92 A;  3N3D A;  4GA3 A;  5CG5 A;  3ZMC A;  5B00 A;  3KRP A;  3W7F A;  4UMJ A;  5ILD A;  3WSB A;  1YHL A;  3DYH A;  4RNQ A;  1UBW A;  1WL3 A;  3WCF A;  5DJP F;  3WC9 A;  4LIX A;  3KRC B;  1WL2 A;  2Z7I A;  4NFJ F;  4RXA A;  1V4E A;  5HN9 A;  2PS8 A;  3WCC A;  3LJI A;  3PH7 A;  1VG2 A;  3ASX A;  5DJR F;  3VJB A;  3LZ9 A;  1HX9 A;  2J5C A;  5B0J A;  3ID0 A;  4LLT A;  1WKZ A;  1ZW5 A;  1DGP A;  4LPH F;  4HD1 A;  3WCD A;  3Q1O A;  5E8H A;  4KVI A;  5AYP A;  3KBK A;  4XQS F;  2E93 A;  3N6K F;  1UBX A;  1YYU A;  1VG4 A;  3PDE A;  2AEK A;  3CP6 A;  2PS7 A;  2AZJ A;  4N1Z F;  4KFA A;  2E94 A;  3APZ A;  3N3L F;  4OKM A;  2O1O A;  4MC0 A;  4XQR F;  4K10 A;  1YJ4 A;  4KQU A;  2E8X A;  3WJN A;  2E8V A;  1HM7 A;  5AHU B;  4QXS F;  4DWG A;  1VG7 A;  1N1Z A;  1N21 A;  3ACY A;  4FP4 A;  1YYQ A;  2Z50 A;  2E8T A;  3EZ3 A;  3QQV A;  3RYE A;  4DWB A;  3EFQ A;  3LDW A;  4JZX A;  2Z4Z A;  3KB9 A;  5IK9 A;  3QKC A;  5IM1 A;  5ILJ A;  1UBY A;  2E95 A;  3KRO B;  4DEM F;  3WCI A;  4LTZ A;  3OYR A;  3V1V A;  5A0K A;  3WCJ A;  1YYT A;  4WK5 A;  3AQB B;  3MZV A;  2PS4 A;  4KQS A;  5AFX A;  4LFG A;  2AET A;  4EA2 A;  4P0X A;  5KSX F;  3V1X A;  5B03 A;  1UBV A;  2Z52 A;  3KRO A;  3N1V F;  4RXD A;  5HN8 A;  5IK6 A;  4GP2 A;  4RXE A;  5DW7 A;  3Q2Q A;  3VJ9 A;  1N22 A;  2ZEV A;  5B0M A;  3SDU A;  1V4K A;  5DGS F;  3CKE A;  2E8W A;  3WEK A;  3WJO A;  5ERN A;  5CG6 A;  3LEE A;  1JFG A;  1RQJ A;  3VJ8 A;  5ERM A;  5JV1 F;  2F9K F;  1FPS A;  4KVY A;  4L2X F;  4RXC A;  5E8K A;  5I1U A;  3LSN A;  4KWD A;  2ZEU A;  3TFP A;  2AZL A;  4GAX A;  3SAE A;  4KVW A;  2ZCO A;  3ZL6 A;  2Z4V A;  3IBA A;  4RYP A;  3ZOU A;  4JXN A;  1RTR A;  4Q23 A;  4LZC A;  2FOR A;  1N20 A;  4LOB A;  3KRA A;  1HXC A;  5A0J A;  3M9U A;  3NPK A;  4JZB A;  4JYX A;  4NKE A;  3SDT A;  3AE0 A;  1WL1 A;  2P1C A;  3ZMB A;  5DGN F;  4KUX A;  4OGU A;  3AQ0 A;  3ZCD A;  4KK2 A;  5IL8 A;  2Z7H A;  1KIY A;  3N5H F;  3VJE A;  3LGK A;  3ADZ A;  3UCA A;  2VF6 A;  5HNA A;  1HM4 A;  2E90 A;  1N23 A;  3VJC A;  1YHM A;  3TFV A;  3LVS A;  3WCH A;  1N24 A;  4LUU A;  5JUZ F;  3N49 F;  2J1P A;  4LFE A;  3RYW A;  3OAB B;  5IVG A;  1JFA A;  4KKM A;  4MC8 A;  5DJV F;  3KRF A;  4H5E F;  5DHI A;  4H5D F;  4P0V A;  4KPJ A;  3LLW A;  5JA0 F;  5AEL A;  2EWG A;  1V4I A;  2FTZ A;  4NKF A; 
#chains in the Genus database with same CATH homology
 4NUA A;  3B7L A;  4E9Z A;  3CC9 A;  1YYR A;  3OAB A;  4PVX F;  5ERO A;  5B0L A;  3LOM A;  5ER8 A;  4OMH A;  3WEI A;  3M01 A;  5IMP A;  3V66 A;  1V4H A;  2I19 A;  5IKA A;  5ILI A;  2F8Z F;  3SDV A;  1YV5 A;  3BNX A;  4LPG F;  4LLS A;  3Q30 A;  2Z4W A;  2RAH A;  5HN7 A;  4N9U A;  3PYB A;  4LFV F;  3WEG A;  4FJQ A;  5EAS A;  3N5J F;  3M0G A;  5IMN A;  2ZY1 A;  4ZQ8 A;  3RBM A;  3WEF A;  1WY0 A;  2Q9Z A;  1N1B A;  3AQC B;  3LK5 A;  3WCA A;  3NF2 A;  3WE9 A;  2H8O A;  4PVY F;  4DI5 A;  5B0K A;  3N0G A;  3ICM A;  5ILH A;  5JV0 F;  3WCB A;  1WL0 A;  4KQ5 A;  3G4D A;  3WCE A;  4KVD A;  4XQT F;  2ONG A;  4F6X A;  4MC3 A;  3M00 A;  2ONH A;  4KPD A;  4LA6 A;  4E9U A;  3N1W F;  3KRA B;  3N46 F;  5IMI A;  1PS1 A;  3ACX A;  3NPR A;  3S9V A;  4EA0 A;  3P5R A;  3P8L A;  3DYG A;  2F7M F;  5DHK A;  5B0I A;  2ZCR A;  4QPF A;  2PS5 A;  3N0F A;  3WCG A;  1V4J A;  5ILZ A;  2AEL A;  3LGZ B;  3LMD A;  5EAT A;  1HXA A;  3P5P A;  3TC1 A;  2ZCS A;  3Q2Z A;  3PKO A;  5C05 A;  4DXJ A;  3WJK A;  1HXG A;  3VJA A;  1RQI A;  5EAU A;  5IL3 A;  2Z4Y A;  3KRC A;  4JXY A;  4NFI F;  1VG6 A;  3OAC B;  4OKZ A;  2OGD A;  3KRF B;  3RMG A;  2Z78 A;  3ICN A;  4P0W A;  5B02 A;  4GP1 A;  2F94 F;  2F92 F;  3ICK A;  2E91 A;  4F62 A;  4NFK F;  4E1E A;  3IPI A;  3SDR A;  1EZF A;  3WEH A;  2OPN A;  5H9D A;  5ILY A;  3NRI A;  3OAC A;  5JV2 F;  3P8R A;  2ZCQ A;  4NG6 A;  5DGM F;  1WMW A;  4LXW A;  3WCM A;  3LG5 A;  4JVJ F;  5E8L A;  3G4F A;  3EGT A;  2E8U A;  4LA5 A;  3TS7 A;  4OMG A;  3VJD A;  5IN8 A;  4EA1 A;  4LZ3 A;  3PYA A;  2OPM A;  3WCL A;  1YQ7 A;  2E4O A;  3M02 A;  2OA6 A;  3ICZ A;  3SDQ A;  5DIQ F;  4H5C F;  4F6V A;  1DI1 A;  2AZK A;  4DZW A;  1YYS A;  2PS6 A;  4LZ0 A;  3TFN A;  3DYF A;  3S4J A;  3P41 A;  2F8C F;  1YHK A;  3WEJ A;  3MAV A;  3N45 F;  2QIS A;  2Q58 A;  2Q80 A;  5IK0 A;  1VG3 A;  2F89 F;  4LTV A;  5A0I A;  5B01 A;  2Z4X A;  4DHD A;  5ILK A;  5IKH A;  3ACW A;  3WSA A;  2DH4 A;  3KRP B;  2Q9Y A;  3BNY A;  1KIZ A;  2J1O A;  5DZ2 A;  2E92 A;  3N3D A;  4GA3 A;  5CG5 A;  3ZMC A;  5B00 A;  3KRP A;  3W7F A;  4UMJ A;  5ILD A;  3WSB A;  1YHL A;  3DYH A;  4RNQ A;  1UBW A;  1WL3 A;  3WCF A;  5DJP F;  3WC9 A;  4LIX A;  3KRC B;  1WL2 A;  2Z7I A;  4NFJ F;  4RXA A;  1V4E A;  5HN9 A;  2PS8 A;  3WCC A;  3LJI A;  3PH7 A;  1VG2 A;  3ASX A;  5DJR F;  3VJB A;  3LZ9 A;  1HX9 A;  2J5C A;  5B0J A;  3ID0 A;  4LLT A;  1WKZ A;  1ZW5 A;  1DGP A;  4LPH F;  4HD1 A;  3WCD A;  3Q1O A;  5E8H A;  4KVI A;  5AYP A;  3KBK A;  4XQS F;  2E93 A;  3N6K F;  1UBX A;  1YYU A;  1VG4 A;  3PDE A;  2AEK A;  3CP6 A;  2PS7 A;  2AZJ A;  4N1Z F;  4KFA A;  2E94 A;  3APZ A;  3N3L F;  4OKM A;  2O1O A;  4MC0 A;  4XQR F;  4K10 A;  1YJ4 A;  4KQU A;  2E8X A;  3WJN A;  2E8V A;  1HM7 A;  5AHU B;  4QXS F;  4DWG A;  1VG7 A;  1N1Z A;  1N21 A;  3ACY A;  4FP4 A;  1YYQ A;  2Z50 A;  2E8T A;  3EZ3 A;  3QQV A;  3RYE A;  4DWB A;  3EFQ A;  3LDW A;  4JZX A;  2Z4Z A;  3KB9 A;  5IK9 A;  3QKC A;  5IM1 A;  5ILJ A;  1UBY A;  2E95 A;  3KRO B;  4DEM F;  3WCI A;  4LTZ A;  3OYR A;  3V1V A;  5A0K A;  3WCJ A;  1YYT A;  4WK5 A;  3AQB B;  3MZV A;  2PS4 A;  4KQS A;  5AFX A;  4LFG A;  2AET A;  4EA2 A;  4P0X A;  5KSX F;  3V1X A;  5B03 A;  1UBV A;  2Z52 A;  3KRO A;  3N1V F;  4RXD A;  5HN8 A;  5IK6 A;  4GP2 A;  4RXE A;  5DW7 A;  3Q2Q A;  3VJ9 A;  1N22 A;  2ZEV A;  5B0M A;  3SDU A;  1V4K A;  5DGS F;  3CKE A;  2E8W A;  3WEK A;  3WJO A;  5ERN A;  5CG6 A;  3LEE A;  1JFG A;  1RQJ A;  3VJ8 A;  5ERM A;  5JV1 F;  2F9K F;  1FPS A;  4KVY A;  4L2X F;  4RXC A;  5E8K A;  5I1U A;  3LSN A;  4KWD A;  2ZEU A;  3TFP A;  2AZL A;  4GAX A;  3SAE A;  4KVW A;  2ZCO A;  3ZL6 A;  2Z4V A;  3IBA A;  4RYP A;  3ZOU A;  4JXN A;  1RTR A;  4Q23 A;  4LZC A;  2FOR A;  1N20 A;  4LOB A;  3KRA A;  1HXC A;  5A0J A;  3M9U A;  3NPK A;  4JZB A;  4JYX A;  4NKE A;  3SDT A;  3AE0 A;  1WL1 A;  2P1C A;  3ZMB A;  5DGN F;  4KUX A;  4OGU A;  3AQ0 A;  3ZCD A;  4KK2 A;  5IL8 A;  2Z7H A;  1KIY A;  3N5H F;  3VJE A;  3LGK A;  3ADZ A;  3UCA A;  2VF6 A;  5HNA A;  1HM4 A;  2E90 A;  1N23 A;  3VJC A;  1YHM A;  3TFV A;  3LVS A;  3WCH A;  1N24 A;  4LUU A;  5JUZ F;  3N49 F;  2J1P A;  4LFE A;  3RYW A;  3OAB B;  5IVG A;  1JFA A;  4KKM A;  4MC8 A;  5DJV F;  3KRF A;  4H5E F;  5DHI A;  4H5D F;  4P0V A;  4KPJ A;  3LLW A;  5JA0 F;  5AEL A;  2EWG A;  1V4I A;  2FTZ A;  4NKF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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