4OGUA

The effects of lysine 200 and phenylalanine 239 farnesyl pyrophosphate synthase (fpps) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
343
structure length
339
Chain Sequence
DVYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNTIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFAQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Farnesyl pyrophosphate synthase
total genus 131
structure length 339
sequence length 343
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2014-01-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 4oguA00
3LEEA 3N6KF 3RMGA 3WCEA 5AHUB 3N45F 2P1CA 1YHMA 4GP2A 4LLSA 5IN8A 5AFXA 5DHKA 2E95A 1KIYA 4F6XA 3AQ0A 3WCIA 1N20A 5ILYA 3KROA 3OACA 3ACXA 4LZCA 5B00A 5HN8A 4LXWA 3IPIA 4ZQ8A 3SDQA 4P0WA 3WEGA 5ERMA 3OABA 3WEJA 3RYWA 2E8TA 3TFNA 3TFPA 3ZCDA 2F7MF 4LFGA 5B0JA 1N22A 4XQRF 3ZL6A 1YQ7A 3N49F 1DGPA 3LOMA 2AZKA 2E8UA 1UBXA 1WY0A 1RQJA 4QPFA 1WMWA 5ILZA 3KRAB 2E94A 4NFJF 4NKFA 3AE0A 4KPDA 3M02A 4RXAA 2F92F 3LGZB 2QISA 3KRFA 4KQUA 5DW7A 1N21A 3N0GA 3PDEA 3ICKA 4P0XA 4GAXA 5IKAA 2EWGA 4LFVF 3WCHA 3QQVA 4RNQA 4OMGA 4FJQA 4EA0A 2RAHA 2AETA 4P0VA 2FTZA 3MAVA 3P5RA 5JV0F 2J1PA 3WJNA 4LZ0A 5DGMF 3WCGA 3KBKA 1HX9A 4NKEA 4LA6A 3ICNA 2E90A 4JVJF 5DIQF 2E8XA 3ICMA 4K10A 3CKEA 5C05A 2PS6A 1YYQA 4RXEA 5JV2F 4H5CF 4E1EA 3PKOA 4JXNA 5ILKA 4FP4A 5A0IA 4KUXA 2Z4VA 4N1ZF 1EZFA 3SDUA 2OA6A 5I1UA 5E8LA 1WL2A 3CC9A 1ZW5A 3EZ3A 1N1ZA 5B02A 3PH7A 4EA1A 2ZEUA 3VJAA 1PS1A 4KK2A 5B0MA 2E8VA 4KPJA 3WCAA 1FPSA 2Z4XA 2ZCSA 3SAEA 3WCLA 4DEMF 5B03A 2PS5A 3Q2QA 4DHDA 2E91A 3LGKA 4H5DF 5EAUA 3DYHA 3M01A 1YV5A 3ICZA 3WEFA 4OKZA 5E8HA 5IL3A 3P8LA 2Z7IA 2J1OA 4H5EF 3ACYA 2F9KF 3BNYA 3WSBA 4KVIA 2Z4ZA 3AQCB 3LVSA 3WCBA 1WL1A 3LDWA 4KQ5A 1HM7A 4PVXF 4NUAA 1KIZA 3ACWA 3ZOUA 5EROA 2OPNA 3NPKA 2J5CA 3LJIA 3EGTA 5DGNF 2FORA 1VG6A 4KFAA 2Q9YA 4XQSF 3N5HF 5ILJA 4NFIF 1JFAA 1VG3A 2F8CF 2Z52A 4MC8A 5IKHA 5IK9A 3VJCA 3P8RA 5IVGA 5IK0A 2ZCQA 3NPRA 5IM1A 3V1VA 5IK6A 3VJEA 4LTZA 1YHKA 1V4JA 3SDRA 5DZ2A 3WEKA 3RYEA 4WK5A 3NRIA 2ONHA 4LPHF 5IMPA 3WCMA 3MZVA 3WSAA 3LG5A 2H8OA 5CG5A 4GP1A 3N0FA 4RXDA 3Q30A 3WJKA 4JZXA 4NFKF 3WJOA 2Q80A 1YYRA 2Z78A 1WL0A 4KWDA 2E8WA 2Z4YA 2OPMA 5EATA 1HXGA 3UCAA 3WCCA 2ZCOA 3CP6A 3B7LA 3LZ9A 4Q23A 3DYFA 3EFQA 3VJBA 3KRAA 1VG2A 1YYTA 4XQTF 3TS7A 2E4OA 3WC9A 2OGDA 1N23A 3S9VA 2ZCRA 3LLWA 3WCJA 3KROB 3ZMBA 4LPGF 4HD1A 1YYUA 2E92A 3M0GA 3M00A 3PYBA 2AEKA 4DWGA 4LOBA 3WE9A 5DJVF 4OMHA 4F62A 4LTVA 4KQSA 5B0KA 3P41A 3PYAA 2ZY1A 5HNAA 2AELA 5IL8A 2PS8A 4LA5A 3LSNA 5HN7A 4LUUA 1WL3A 3S4JA 2VF6A 3Q1OA 4DWBA 1N24A 4L2XF 3QKCA 4NG6A 4N9UA 1V4HA 2F94F 5DGSF 3G4DA 5IMIA 2Z4WA 2O1OA 3Q2ZA 3M9UA 4QXSF 1V4EA 3N5JF 5JA0F 3KRFB 4OGUA 1WKZA 5A0KA 4KVDA 5HN9A 1HXCA 5E8KA 1YJ4A 4PVYF 4LZ3A 5JUZF 3ID0A 2Q9ZA 3NF2A 5KSXF 4JYXA 2PS7A 4JZBA 2E93A 4DZWA 5AYPA 5CG6A 5A0JA 1VG7A 3N1VF 5H9DA 3ADZA 4GA3A 1YYSA 4E9ZA 3WEIA 3OYRA 3WEHA 1HXAA 5ILDA 3KB9A 3N1WF 2ONGA 4MC0A 4LIXA 4UMJA 3SDVA 3KRPB 1VG4A 1V4IA 4KVYA 3KRCB 4MC3A 3BNXA 4DXJA 4LFEA 1UBYA 1V4KA 3N46F 3APZA 1HM4A 3AQBB 2I19A 4RXCA 3W7FA 5AELA 1RQIA 4JXYA 3N3DA 3N3LF 2AZLA 1N1BA 1UBVA 3TC1A 3G4FA 3V1XA 2F89F 2AZJA 5IMNA 2ZEVA 1DI1A 3DYGA 2Q58A 3VJ9A 5ILIA 3ZMCA 3LMDA 3IBAA 4DI5A 3VJDA 5JV1F 5B0IA 5EASA 3VJ8A 4EA2A 1UBWA 5DHIA 3V66A 3OACB 4LLTA 2F8ZF 4OKMA 2DH4A 3WCFA 3OABB 5B01A 3P5PA 4RYPA 5B0LA 3RBMA 5ILHA 3KRPA 1YHLA 2Z7HA 4KVWA 3LK5A 3WCDA 5DJPF 3KRCA 5DJRF 1JFGA 4F6VA 5ER8A 1RTRA 4KKMA 2Z50A 2PS4A 4E9UA 3TFVA 3SDTA 3ASXA 5ERNA
chains in the Genus database with same CATH superfamily
3LEEA 3N6KF 3RMGA 3WCEA 5AHUB 3N45F 2P1CA 1YHMA 4GP2A 4LLSA 5IN8A 5AFXA 5DHKA 2E95A 1KIYA 4F6XA 3AQ0A 3WCIA 1N20A 5ILYA 3KROA 3OACA 3ACXA 4LZCA 5B00A 5HN8A 4LXWA 3IPIA 4ZQ8A 3SDQA 4P0WA 3WEGA 5ERMA 3OABA 3WEJA 3RYWA 2E8TA 3TFNA 3TFPA 3ZCDA 2F7MF 4LFGA 5B0JA 1N22A 4XQRF 3ZL6A 1YQ7A 3N49F 1DGPA 3LOMA 2AZKA 2E8UA 1UBXA 1WY0A 1RQJA 4QPFA 1WMWA 5ILZA 3KRAB 2E94A 4NFJF 4NKFA 3AE0A 4KPDA 3M02A 4RXAA 2F92F 3LGZB 2QISA 3KRFA 4KQUA 5DW7A 1N21A 3N0GA 3PDEA 3ICKA 4P0XA 4GAXA 5IKAA 2EWGA 4LFVF 3WCHA 3QQVA 4RNQA 4OMGA 4FJQA 4EA0A 2RAHA 2AETA 4P0VA 2FTZA 3MAVA 3P5RA 5JV0F 2J1PA 3WJNA 4LZ0A 5DGMF 3WCGA 3KBKA 1HX9A 4NKEA 4LA6A 3ICNA 2E90A 4JVJF 5DIQF 2E8XA 3ICMA 4K10A 3CKEA 5C05A 2PS6A 1YYQA 4RXEA 5JV2F 4H5CF 4E1EA 3PKOA 4JXNA 5ILKA 4FP4A 5A0IA 4KUXA 2Z4VA 4N1ZF 1EZFA 3SDUA 2OA6A 5I1UA 5E8LA 1WL2A 3CC9A 1ZW5A 3EZ3A 1N1ZA 5B02A 3PH7A 4EA1A 2ZEUA 3VJAA 1PS1A 4KK2A 5B0MA 2E8VA 4KPJA 3WCAA 1FPSA 2Z4XA 2ZCSA 3SAEA 3WCLA 4DEMF 5B03A 2PS5A 3Q2QA 4DHDA 2E91A 3LGKA 4H5DF 5EAUA 3DYHA 3M01A 1YV5A 3ICZA 3WEFA 4OKZA 5E8HA 5IL3A 3P8LA 2Z7IA 2J1OA 4H5EF 3ACYA 2F9KF 3BNYA 3WSBA 4KVIA 2Z4ZA 3AQCB 3LVSA 3WCBA 1WL1A 3LDWA 4KQ5A 1HM7A 4PVXF 4NUAA 1KIZA 3ACWA 3ZOUA 5EROA 2OPNA 3NPKA 2J5CA 3LJIA 3EGTA 5DGNF 2FORA 1VG6A 4KFAA 2Q9YA 4XQSF 3N5HF 5ILJA 4NFIF 1JFAA 1VG3A 2F8CF 2Z52A 4MC8A 5IKHA 5IK9A 3VJCA 3P8RA 5IVGA 5IK0A 2ZCQA 3NPRA 5IM1A 3V1VA 5IK6A 3VJEA 4LTZA 1YHKA 1V4JA 3SDRA 5DZ2A 3WEKA 3RYEA 4WK5A 3NRIA 2ONHA 4LPHF 5IMPA 3WCMA 3MZVA 3WSAA 3LG5A 2H8OA 5CG5A 4GP1A 3N0FA 4RXDA 3Q30A 3WJKA 4JZXA 4NFKF 3WJOA 2Q80A 1YYRA 2Z78A 1WL0A 4KWDA 2E8WA 2Z4YA 2OPMA 5EATA 1HXGA 3UCAA 3WCCA 2ZCOA 3CP6A 3B7LA 3LZ9A 4Q23A 3DYFA 3EFQA 3VJBA 3KRAA 1VG2A 1YYTA 4XQTF 3TS7A 2E4OA 3WC9A 2OGDA 1N23A 3S9VA 2ZCRA 3LLWA 3WCJA 3KROB 3ZMBA 4LPGF 4HD1A 1YYUA 2E92A 3M0GA 3M00A 3PYBA 2AEKA 4DWGA 4LOBA 3WE9A 5DJVF 4OMHA 4F62A 4LTVA 4KQSA 5B0KA 3P41A 3PYAA 2ZY1A 5HNAA 2AELA 5IL8A 2PS8A 4LA5A 3LSNA 5HN7A 4LUUA 1WL3A 3S4JA 2VF6A 3Q1OA 4DWBA 1N24A 4L2XF 3QKCA 4NG6A 4N9UA 1V4HA 2F94F 5DGSF 3G4DA 5IMIA 2Z4WA 2O1OA 3Q2ZA 3M9UA 4QXSF 1V4EA 3N5JF 5JA0F 3KRFB 4OGUA 1WKZA 5A0KA 4KVDA 5HN9A 1HXCA 5E8KA 1YJ4A 4PVYF 4LZ3A 5JUZF 3ID0A 2Q9ZA 3NF2A 5KSXF 4JYXA 2PS7A 4JZBA 2E93A 4DZWA 5AYPA 5CG6A 5A0JA 1VG7A 3N1VF 5H9DA 3ADZA 4GA3A 1YYSA 4E9ZA 3WEIA 3OYRA 3WEHA 1HXAA 5ILDA 3KB9A 3N1WF 2ONGA 4MC0A 4LIXA 4UMJA 3SDVA 3KRPB 1VG4A 1V4IA 4KVYA 3KRCB 4MC3A 3BNXA 4DXJA 4LFEA 1UBYA 1V4KA 3N46F 3APZA 1HM4A 3AQBB 2I19A 4RXCA 3W7FA 5AELA 1RQIA 4JXYA 3N3DA 3N3LF 2AZLA 1N1BA 1UBVA 3TC1A 3G4FA 3V1XA 2F89F 2AZJA 5IMNA 2ZEVA 1DI1A 3DYGA 2Q58A 3VJ9A 5ILIA 3ZMCA 3LMDA 3IBAA 4DI5A 3VJDA 5JV1F 5B0IA 5EASA 3VJ8A 4EA2A 1UBWA 5DHIA 3V66A 3OACB 4LLTA 2F8ZF 4OKMA 2DH4A 3WCFA 3OABB 5B01A 3P5PA 4RYPA 5B0LA 3RBMA 5ILHA 3KRPA 1YHLA 2Z7HA 4KVWA 3LK5A 3WCDA 5DJPF 3KRCA 5DJRF 1JFGA 4F6VA 5ER8A 1RTRA 4KKMA 2Z50A 2PS4A 4E9UA 3TFVA 3SDTA 3ASXA 5ERNA
chains in the Genus database with same CATH topology
3LEEA 3N6KF 3RMGA 3WCEA 5AHUB 3N45F 2P1CA 1YHMA 4GP2A 4LLSA 5IN8A 5AFXA 5DHKA 2E95A 1KIYA 4F6XA 3AQ0A 3WCIA 1N20A 5ILYA 3KROA 3OACA 3ACXA 4LZCA 5B00A 5HN8A 4LXWA 3IPIA 4ZQ8A 3SDQA 4P0WA 3WEGA 5ERMA 3OABA 3WEJA 3RYWA 2E8TA 3TFNA 3TFPA 3ZCDA 2F7MF 4LFGA 5B0JA 1N22A 4XQRF 3ZL6A 1YQ7A 3N49F 1DGPA 3LOMA 2AZKA 2E8UA 1UBXA 1WY0A 1RQJA 4QPFA 1WMWA 5ILZA 3KRAB 2E94A 4NFJF 4NKFA 3AE0A 4KPDA 3M02A 4RXAA 2F92F 3LGZB 2QISA 3KRFA 4KQUA 5DW7A 1N21A 3N0GA 3PDEA 3ICKA 4P0XA 4GAXA 5IKAA 2EWGA 4LFVF 3WCHA 3QQVA 4RNQA 4OMGA 4FJQA 4EA0A 2RAHA 2AETA 4P0VA 2FTZA 3MAVA 3P5RA 5JV0F 2J1PA 3WJNA 4LZ0A 5DGMF 3WCGA 3KBKA 1HX9A 4NKEA 4LA6A 3ICNA 2E90A 4JVJF 5DIQF 2E8XA 3ICMA 4K10A 3CKEA 5C05A 2PS6A 1YYQA 4RXEA 5JV2F 4H5CF 4E1EA 3PKOA 4JXNA 5ILKA 4FP4A 5A0IA 4KUXA 2Z4VA 4N1ZF 1EZFA 3SDUA 2OA6A 5I1UA 5E8LA 1WL2A 3CC9A 1ZW5A 3EZ3A 1N1ZA 5B02A 3PH7A 4EA1A 2ZEUA 3VJAA 1PS1A 4KK2A 5B0MA 2E8VA 4KPJA 3WCAA 1FPSA 2Z4XA 2ZCSA 3SAEA 3WCLA 4DEMF 5B03A 2PS5A 3Q2QA 4DHDA 2E91A 3LGKA 4H5DF 5EAUA 3DYHA 3M01A 1YV5A 3ICZA 3WEFA 4OKZA 5E8HA 5IL3A 3P8LA 2Z7IA 2J1OA 4H5EF 3ACYA 2F9KF 3BNYA 3WSBA 4KVIA 2Z4ZA 3AQCB 3LVSA 3WCBA 1WL1A 3LDWA 4KQ5A 1HM7A 4PVXF 4NUAA 1KIZA 3ACWA 3ZOUA 5EROA 2OPNA 3NPKA 2J5CA 3LJIA 3EGTA 5DGNF 2FORA 1VG6A 4KFAA 2Q9YA 4XQSF 3N5HF 5ILJA 4NFIF 1JFAA 1VG3A 2F8CF 2Z52A 4MC8A 5IKHA 5IK9A 3VJCA 3P8RA 5IVGA 5IK0A 2ZCQA 3NPRA 5IM1A 3V1VA 5IK6A 3VJEA 4LTZA 1YHKA 1V4JA 3SDRA 5DZ2A 3WEKA 3RYEA 4WK5A 3NRIA 2ONHA 4LPHF 5IMPA 3WCMA 3MZVA 3WSAA 3LG5A 2H8OA 5CG5A 4GP1A 3N0FA 4RXDA 3Q30A 3WJKA 4JZXA 4NFKF 3WJOA 2Q80A 1YYRA 2Z78A 1WL0A 4KWDA 2E8WA 2Z4YA 2OPMA 5EATA 1HXGA 3UCAA 3WCCA 2ZCOA 3CP6A 3B7LA 3LZ9A 4Q23A 3DYFA 3EFQA 3VJBA 3KRAA 1VG2A 1YYTA 4XQTF 3TS7A 2E4OA 3WC9A 2OGDA 1N23A 3S9VA 2ZCRA 3LLWA 3WCJA 3KROB 3ZMBA 4LPGF 4HD1A 1YYUA 2E92A 3M0GA 3M00A 3PYBA 2AEKA 4DWGA 4LOBA 3WE9A 5DJVF 4OMHA 4F62A 4LTVA 4KQSA 5B0KA 3P41A 3PYAA 2ZY1A 5HNAA 2AELA 5IL8A 2PS8A 4LA5A 3LSNA 5HN7A 4LUUA 1WL3A 3S4JA 2VF6A 3Q1OA 4DWBA 1N24A 4L2XF 3QKCA 4NG6A 4N9UA 1V4HA 2F94F 5DGSF 3G4DA 5IMIA 2Z4WA 2O1OA 3Q2ZA 3M9UA 4QXSF 1V4EA 3N5JF 5JA0F 3KRFB 4OGUA 1WKZA 5A0KA 4KVDA 5HN9A 1HXCA 5E8KA 1YJ4A 4PVYF 4LZ3A 5JUZF 3ID0A 2Q9ZA 3NF2A 5KSXF 4JYXA 2PS7A 4JZBA 2E93A 4DZWA 5AYPA 5CG6A 5A0JA 1VG7A 3N1VF 5H9DA 3ADZA 4GA3A 1YYSA 4E9ZA 3WEIA 3OYRA 3WEHA 1HXAA 5ILDA 3KB9A 3N1WF 2ONGA 4MC0A 4LIXA 4UMJA 3SDVA 3KRPB 1VG4A 1V4IA 4KVYA 3KRCB 4MC3A 3BNXA 4DXJA 4LFEA 1UBYA 1V4KA 3N46F 3APZA 1HM4A 3AQBB 2I19A 4RXCA 3W7FA 5AELA 1RQIA 4JXYA 3N3DA 3N3LF 2AZLA 1N1BA 1UBVA 3TC1A 3G4FA 3V1XA 2F89F 2AZJA 5IMNA 2ZEVA 1DI1A 3DYGA 2Q58A 3VJ9A 5ILIA 3ZMCA 3LMDA 3IBAA 4DI5A 3VJDA 5JV1F 5B0IA 5EASA 3VJ8A 4EA2A 1UBWA 5DHIA 3V66A 3OACB 4LLTA 2F8ZF 4OKMA 2DH4A 3WCFA 3OABB 5B01A 3P5PA 4RYPA 5B0LA 3RBMA 5ILHA 3KRPA 1YHLA 2Z7HA 4KVWA 3LK5A 3WCDA 5DJPF 3KRCA 5DJRF 1JFGA 4F6VA 5ER8A 1RTRA 4KKMA 2Z50A 2PS4A 4E9UA 3TFVA 3SDTA 3ASXA 5ERNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LEE A;  3N6K F;  3RMG A;  3WCE A;  5AHU B;  3N45 F;  2P1C A;  1YHM A;  4GP2 A;  4LLS A;  5IN8 A;  5AFX A;  5DHK A;  2E95 A;  1KIY A;  4F6X A;  3AQ0 A;  3WCI A;  1N20 A;  5ILY A;  3KRO A;  3OAC A;  3ACX A;  4LZC A;  5B00 A;  5HN8 A;  4LXW A;  3IPI A;  4ZQ8 A;  3SDQ A;  4P0W A;  3WEG A;  5ERM A;  3OAB A;  3WEJ A;  3RYW A;  2E8T A;  3TFN A;  3TFP A;  3ZCD A;  2F7M F;  4LFG A;  5B0J A;  1N22 A;  4XQR F;  3ZL6 A;  1YQ7 A;  3N49 F;  1DGP A;  3LOM A;  2AZK A;  2E8U A;  1UBX A;  1WY0 A;  1RQJ A;  4QPF A;  1WMW A;  5ILZ A;  3KRA B;  2E94 A;  4NFJ F;  4NKF A;  3AE0 A;  4KPD A;  3M02 A;  4RXA A;  2F92 F;  3LGZ B;  2QIS A;  3KRF A;  4KQU A;  5DW7 A;  1N21 A;  3N0G A;  3PDE A;  3ICK A;  4P0X A;  4GAX A;  5IKA A;  2EWG A;  4LFV F;  3WCH A;  3QQV A;  4RNQ A;  4OMG A;  4FJQ A;  4EA0 A;  2RAH A;  2AET A;  4P0V A;  2FTZ A;  3MAV A;  3P5R A;  5JV0 F;  2J1P A;  3WJN A;  4LZ0 A;  5DGM F;  3WCG A;  3KBK A;  1HX9 A;  4NKE A;  4LA6 A;  3ICN A;  2E90 A;  4JVJ F;  5DIQ F;  2E8X A;  3ICM A;  4K10 A;  3CKE A;  5C05 A;  2PS6 A;  1YYQ A;  4RXE A;  5JV2 F;  4H5C F;  4E1E A;  3PKO A;  4JXN A;  5ILK A;  4FP4 A;  5A0I A;  4KUX A;  2Z4V A;  4N1Z F;  1EZF A;  3SDU A;  2OA6 A;  5I1U A;  5E8L A;  1WL2 A;  3CC9 A;  1ZW5 A;  3EZ3 A;  1N1Z A;  5B02 A;  3PH7 A;  4EA1 A;  2ZEU A;  3VJA A;  1PS1 A;  4KK2 A;  5B0M A;  2E8V A;  4KPJ A;  3WCA A;  1FPS A;  2Z4X A;  2ZCS A;  3SAE A;  3WCL A;  4DEM F;  5B03 A;  2PS5 A;  3Q2Q A;  4DHD A;  2E91 A;  3LGK A;  4H5D F;  5EAU A;  3DYH A;  3M01 A;  1YV5 A;  3ICZ A;  3WEF A;  4OKZ A;  5E8H A;  5IL3 A;  3P8L A;  2Z7I A;  2J1O A;  4H5E F;  3ACY A;  2F9K F;  3BNY A;  3WSB A;  4KVI A;  2Z4Z A;  3AQC B;  3LVS A;  3WCB A;  1WL1 A;  3LDW A;  4KQ5 A;  1HM7 A;  4PVX F;  4NUA A;  1KIZ A;  3ACW A;  3ZOU A;  5ERO A;  2OPN A;  3NPK A;  2J5C A;  3LJI A;  3EGT A;  5DGN F;  2FOR A;  1VG6 A;  4KFA A;  2Q9Y A;  4XQS F;  3N5H F;  5ILJ A;  4NFI F;  1JFA A;  1VG3 A;  2F8C F;  2Z52 A;  4MC8 A;  5IKH A;  5IK9 A;  3VJC A;  3P8R A;  5IVG A;  5IK0 A;  2ZCQ A;  3NPR A;  5IM1 A;  3V1V A;  5IK6 A;  3VJE A;  4LTZ A;  1YHK A;  1V4J A;  3SDR A;  5DZ2 A;  3WEK A;  3RYE A;  4WK5 A;  3NRI A;  2ONH A;  4LPH F;  5IMP A;  3WCM A;  3MZV A;  3WSA A;  3LG5 A;  2H8O A;  5CG5 A;  4GP1 A;  3N0F A;  4RXD A;  3Q30 A;  3WJK A;  4JZX A;  4NFK F;  3WJO A;  2Q80 A;  1YYR A;  2Z78 A;  1WL0 A;  4KWD A;  2E8W A;  2Z4Y A;  2OPM A;  5EAT A;  1HXG A;  3UCA A;  3WCC A;  2ZCO A;  3CP6 A;  3B7L A;  3LZ9 A;  4Q23 A;  3DYF A;  3EFQ A;  3VJB A;  3KRA A;  1VG2 A;  1YYT A;  4XQT F;  3TS7 A;  2E4O A;  3WC9 A;  2OGD A;  1N23 A;  3S9V A;  2ZCR A;  3LLW A;  3WCJ A;  3KRO B;  3ZMB A;  4LPG F;  4HD1 A;  1YYU A;  2E92 A;  3M0G A;  3M00 A;  3PYB A;  2AEK A;  4DWG A;  4LOB A;  3WE9 A;  5DJV F;  4OMH A;  4F62 A;  4LTV A;  4KQS A;  5B0K A;  3P41 A;  3PYA A;  2ZY1 A;  5HNA A;  2AEL A;  5IL8 A;  2PS8 A;  4LA5 A;  3LSN A;  5HN7 A;  4LUU A;  1WL3 A;  3S4J A;  2VF6 A;  3Q1O A;  4DWB A;  1N24 A;  4L2X F;  3QKC A;  4NG6 A;  4N9U A;  1V4H A;  2F94 F;  5DGS F;  3G4D A;  5IMI A;  2Z4W A;  2O1O A;  3Q2Z A;  3M9U A;  4QXS F;  1V4E A;  3N5J F;  5JA0 F;  3KRF B;  4OGU A;  1WKZ A;  5A0K A;  4KVD A;  5HN9 A;  1HXC A;  5E8K A;  1YJ4 A;  4PVY F;  4LZ3 A;  5JUZ F;  3ID0 A;  2Q9Z A;  3NF2 A;  5KSX F;  4JYX A;  2PS7 A;  4JZB A;  2E93 A;  4DZW A;  5AYP A;  5CG6 A;  5A0J A;  1VG7 A;  3N1V F;  5H9D A;  3ADZ A;  4GA3 A;  1YYS A;  4E9Z A;  3WEI A;  3OYR A;  3WEH A;  1HXA A;  5ILD A;  3KB9 A;  3N1W F;  2ONG A;  4MC0 A;  4LIX A;  4UMJ A;  3SDV A;  3KRP B;  1VG4 A;  1V4I A;  4KVY A;  3KRC B;  4MC3 A;  3BNX A;  4DXJ A;  4LFE A;  1UBY A;  1V4K A;  3N46 F;  3APZ A;  1HM4 A;  3AQB B;  2I19 A;  4RXC A;  3W7F A;  5AEL A;  1RQI A;  4JXY A;  3N3D A;  3N3L F;  2AZL A;  1N1B A;  1UBV A;  3TC1 A;  3G4F A;  3V1X A;  2F89 F;  2AZJ A;  5IMN A;  2ZEV A;  1DI1 A;  3DYG A;  2Q58 A;  3VJ9 A;  5ILI A;  3ZMC A;  3LMD A;  3IBA A;  4DI5 A;  3VJD A;  5JV1 F;  5B0I A;  5EAS A;  3VJ8 A;  4EA2 A;  1UBW A;  5DHI A;  3V66 A;  3OAC B;  4LLT A;  2F8Z F;  4OKM A;  2DH4 A;  3WCF A;  3OAB B;  5B01 A;  3P5P A;  4RYP A;  5B0L A;  3RBM A;  5ILH A;  3KRP A;  1YHL A;  2Z7H A;  4KVW A;  3LK5 A;  3WCD A;  5DJP F;  3KRC A;  5DJR F;  1JFG A;  4F6V A;  5ER8 A;  1RTR A;  4KKM A;  2Z50 A;  2PS4 A;  4E9U A;  3TFV A;  3SDT A;  3ASX A;  5ERN A; 
#chains in the Genus database with same CATH topology
 3LEE A;  3N6K F;  3RMG A;  3WCE A;  5AHU B;  3N45 F;  2P1C A;  1YHM A;  4GP2 A;  4LLS A;  5IN8 A;  5AFX A;  5DHK A;  2E95 A;  1KIY A;  4F6X A;  3AQ0 A;  3WCI A;  1N20 A;  5ILY A;  3KRO A;  3OAC A;  3ACX A;  4LZC A;  5B00 A;  5HN8 A;  4LXW A;  3IPI A;  4ZQ8 A;  3SDQ A;  4P0W A;  3WEG A;  5ERM A;  3OAB A;  3WEJ A;  3RYW A;  2E8T A;  3TFN A;  3TFP A;  3ZCD A;  2F7M F;  4LFG A;  5B0J A;  1N22 A;  4XQR F;  3ZL6 A;  1YQ7 A;  3N49 F;  1DGP A;  3LOM A;  2AZK A;  2E8U A;  1UBX A;  1WY0 A;  1RQJ A;  4QPF A;  1WMW A;  5ILZ A;  3KRA B;  2E94 A;  4NFJ F;  4NKF A;  3AE0 A;  4KPD A;  3M02 A;  4RXA A;  2F92 F;  3LGZ B;  2QIS A;  3KRF A;  4KQU A;  5DW7 A;  1N21 A;  3N0G A;  3PDE A;  3ICK A;  4P0X A;  4GAX A;  5IKA A;  2EWG A;  4LFV F;  3WCH A;  3QQV A;  4RNQ A;  4OMG A;  4FJQ A;  4EA0 A;  2RAH A;  2AET A;  4P0V A;  2FTZ A;  3MAV A;  3P5R A;  5JV0 F;  2J1P A;  3WJN A;  4LZ0 A;  5DGM F;  3WCG A;  3KBK A;  1HX9 A;  4NKE A;  4LA6 A;  3ICN A;  2E90 A;  4JVJ F;  5DIQ F;  2E8X A;  3ICM A;  4K10 A;  3CKE A;  5C05 A;  2PS6 A;  1YYQ A;  4RXE A;  5JV2 F;  4H5C F;  4E1E A;  3PKO A;  4JXN A;  5ILK A;  4FP4 A;  5A0I A;  4KUX A;  2Z4V A;  4N1Z F;  1EZF A;  3SDU A;  2OA6 A;  5I1U A;  5E8L A;  1WL2 A;  3CC9 A;  1ZW5 A;  3EZ3 A;  1N1Z A;  5B02 A;  3PH7 A;  4EA1 A;  2ZEU A;  3VJA A;  1PS1 A;  4KK2 A;  5B0M A;  2E8V A;  4KPJ A;  3WCA A;  1FPS A;  2Z4X A;  2ZCS A;  3SAE A;  3WCL A;  4DEM F;  5B03 A;  2PS5 A;  3Q2Q A;  4DHD A;  2E91 A;  3LGK A;  4H5D F;  5EAU A;  3DYH A;  3M01 A;  1YV5 A;  3ICZ A;  3WEF A;  4OKZ A;  5E8H A;  5IL3 A;  3P8L A;  2Z7I A;  2J1O A;  4H5E F;  3ACY A;  2F9K F;  3BNY A;  3WSB A;  4KVI A;  2Z4Z A;  3AQC B;  3LVS A;  3WCB A;  1WL1 A;  3LDW A;  4KQ5 A;  1HM7 A;  4PVX F;  4NUA A;  1KIZ A;  3ACW A;  3ZOU A;  5ERO A;  2OPN A;  3NPK A;  2J5C A;  3LJI A;  3EGT A;  5DGN F;  2FOR A;  1VG6 A;  4KFA A;  2Q9Y A;  4XQS F;  3N5H F;  5ILJ A;  4NFI F;  1JFA A;  1VG3 A;  2F8C F;  2Z52 A;  4MC8 A;  5IKH A;  5IK9 A;  3VJC A;  3P8R A;  5IVG A;  5IK0 A;  2ZCQ A;  3NPR A;  5IM1 A;  3V1V A;  5IK6 A;  3VJE A;  4LTZ A;  1YHK A;  1V4J A;  3SDR A;  5DZ2 A;  3WEK A;  3RYE A;  4WK5 A;  3NRI A;  2ONH A;  4LPH F;  5IMP A;  3WCM A;  3MZV A;  3WSA A;  3LG5 A;  2H8O A;  5CG5 A;  4GP1 A;  3N0F A;  4RXD A;  3Q30 A;  3WJK A;  4JZX A;  4NFK F;  3WJO A;  2Q80 A;  1YYR A;  2Z78 A;  1WL0 A;  4KWD A;  2E8W A;  2Z4Y A;  2OPM A;  5EAT A;  1HXG A;  3UCA A;  3WCC A;  2ZCO A;  3CP6 A;  3B7L A;  3LZ9 A;  4Q23 A;  3DYF A;  3EFQ A;  3VJB A;  3KRA A;  1VG2 A;  1YYT A;  4XQT F;  3TS7 A;  2E4O A;  3WC9 A;  2OGD A;  1N23 A;  3S9V A;  2ZCR A;  3LLW A;  3WCJ A;  3KRO B;  3ZMB A;  4LPG F;  4HD1 A;  1YYU A;  2E92 A;  3M0G A;  3M00 A;  3PYB A;  2AEK A;  4DWG A;  4LOB A;  3WE9 A;  5DJV F;  4OMH A;  4F62 A;  4LTV A;  4KQS A;  5B0K A;  3P41 A;  3PYA A;  2ZY1 A;  5HNA A;  2AEL A;  5IL8 A;  2PS8 A;  4LA5 A;  3LSN A;  5HN7 A;  4LUU A;  1WL3 A;  3S4J A;  2VF6 A;  3Q1O A;  4DWB A;  1N24 A;  4L2X F;  3QKC A;  4NG6 A;  4N9U A;  1V4H A;  2F94 F;  5DGS F;  3G4D A;  5IMI A;  2Z4W A;  2O1O A;  3Q2Z A;  3M9U A;  4QXS F;  1V4E A;  3N5J F;  5JA0 F;  3KRF B;  4OGU A;  1WKZ A;  5A0K A;  4KVD A;  5HN9 A;  1HXC A;  5E8K A;  1YJ4 A;  4PVY F;  4LZ3 A;  5JUZ F;  3ID0 A;  2Q9Z A;  3NF2 A;  5KSX F;  4JYX A;  2PS7 A;  4JZB A;  2E93 A;  4DZW A;  5AYP A;  5CG6 A;  5A0J A;  1VG7 A;  3N1V F;  5H9D A;  3ADZ A;  4GA3 A;  1YYS A;  4E9Z A;  3WEI A;  3OYR A;  3WEH A;  1HXA A;  5ILD A;  3KB9 A;  3N1W F;  2ONG A;  4MC0 A;  4LIX A;  4UMJ A;  3SDV A;  3KRP B;  1VG4 A;  1V4I A;  4KVY A;  3KRC B;  4MC3 A;  3BNX A;  4DXJ A;  4LFE A;  1UBY A;  1V4K A;  3N46 F;  3APZ A;  1HM4 A;  3AQB B;  2I19 A;  4RXC A;  3W7F A;  5AEL A;  1RQI A;  4JXY A;  3N3D A;  3N3L F;  2AZL A;  1N1B A;  1UBV A;  3TC1 A;  3G4F A;  3V1X A;  2F89 F;  2AZJ A;  5IMN A;  2ZEV A;  1DI1 A;  3DYG A;  2Q58 A;  3VJ9 A;  5ILI A;  3ZMC A;  3LMD A;  3IBA A;  4DI5 A;  3VJD A;  5JV1 F;  5B0I A;  5EAS A;  3VJ8 A;  4EA2 A;  1UBW A;  5DHI A;  3V66 A;  3OAC B;  4LLT A;  2F8Z F;  4OKM A;  2DH4 A;  3WCF A;  3OAB B;  5B01 A;  3P5P A;  4RYP A;  5B0L A;  3RBM A;  5ILH A;  3KRP A;  1YHL A;  2Z7H A;  4KVW A;  3LK5 A;  3WCD A;  5DJP F;  3KRC A;  5DJR F;  1JFG A;  4F6V A;  5ER8 A;  1RTR A;  4KKM A;  2Z50 A;  2PS4 A;  4E9U A;  3TFV A;  3SDT A;  3ASX A;  5ERN A; 
#chains in the Genus database with same CATH homology
 3LEE A;  3N6K F;  3RMG A;  3WCE A;  5AHU B;  3N45 F;  2P1C A;  1YHM A;  4GP2 A;  4LLS A;  5IN8 A;  5AFX A;  5DHK A;  2E95 A;  1KIY A;  4F6X A;  3AQ0 A;  3WCI A;  1N20 A;  5ILY A;  3KRO A;  3OAC A;  3ACX A;  4LZC A;  5B00 A;  5HN8 A;  4LXW A;  3IPI A;  4ZQ8 A;  3SDQ A;  4P0W A;  3WEG A;  5ERM A;  3OAB A;  3WEJ A;  3RYW A;  2E8T A;  3TFN A;  3TFP A;  3ZCD A;  2F7M F;  4LFG A;  5B0J A;  1N22 A;  4XQR F;  3ZL6 A;  1YQ7 A;  3N49 F;  1DGP A;  3LOM A;  2AZK A;  2E8U A;  1UBX A;  1WY0 A;  1RQJ A;  4QPF A;  1WMW A;  5ILZ A;  3KRA B;  2E94 A;  4NFJ F;  4NKF A;  3AE0 A;  4KPD A;  3M02 A;  4RXA A;  2F92 F;  3LGZ B;  2QIS A;  3KRF A;  4KQU A;  5DW7 A;  1N21 A;  3N0G A;  3PDE A;  3ICK A;  4P0X A;  4GAX A;  5IKA A;  2EWG A;  4LFV F;  3WCH A;  3QQV A;  4RNQ A;  4OMG A;  4FJQ A;  4EA0 A;  2RAH A;  2AET A;  4P0V A;  2FTZ A;  3MAV A;  3P5R A;  5JV0 F;  2J1P A;  3WJN A;  4LZ0 A;  5DGM F;  3WCG A;  3KBK A;  1HX9 A;  4NKE A;  4LA6 A;  3ICN A;  2E90 A;  4JVJ F;  5DIQ F;  2E8X A;  3ICM A;  4K10 A;  3CKE A;  5C05 A;  2PS6 A;  1YYQ A;  4RXE A;  5JV2 F;  4H5C F;  4E1E A;  3PKO A;  4JXN A;  5ILK A;  4FP4 A;  5A0I A;  4KUX A;  2Z4V A;  4N1Z F;  1EZF A;  3SDU A;  2OA6 A;  5I1U A;  5E8L A;  1WL2 A;  3CC9 A;  1ZW5 A;  3EZ3 A;  1N1Z A;  5B02 A;  3PH7 A;  4EA1 A;  2ZEU A;  3VJA A;  1PS1 A;  4KK2 A;  5B0M A;  2E8V A;  4KPJ A;  3WCA A;  1FPS A;  2Z4X A;  2ZCS A;  3SAE A;  3WCL A;  4DEM F;  5B03 A;  2PS5 A;  3Q2Q A;  4DHD A;  2E91 A;  3LGK A;  4H5D F;  5EAU A;  3DYH A;  3M01 A;  1YV5 A;  3ICZ A;  3WEF A;  4OKZ A;  5E8H A;  5IL3 A;  3P8L A;  2Z7I A;  2J1O A;  4H5E F;  3ACY A;  2F9K F;  3BNY A;  3WSB A;  4KVI A;  2Z4Z A;  3AQC B;  3LVS A;  3WCB A;  1WL1 A;  3LDW A;  4KQ5 A;  1HM7 A;  4PVX F;  4NUA A;  1KIZ A;  3ACW A;  3ZOU A;  5ERO A;  2OPN A;  3NPK A;  2J5C A;  3LJI A;  3EGT A;  5DGN F;  2FOR A;  1VG6 A;  4KFA A;  2Q9Y A;  4XQS F;  3N5H F;  5ILJ A;  4NFI F;  1JFA A;  1VG3 A;  2F8C F;  2Z52 A;  4MC8 A;  5IKH A;  5IK9 A;  3VJC A;  3P8R A;  5IVG A;  5IK0 A;  2ZCQ A;  3NPR A;  5IM1 A;  3V1V A;  5IK6 A;  3VJE A;  4LTZ A;  1YHK A;  1V4J A;  3SDR A;  5DZ2 A;  3WEK A;  3RYE A;  4WK5 A;  3NRI A;  2ONH A;  4LPH F;  5IMP A;  3WCM A;  3MZV A;  3WSA A;  3LG5 A;  2H8O A;  5CG5 A;  4GP1 A;  3N0F A;  4RXD A;  3Q30 A;  3WJK A;  4JZX A;  4NFK F;  3WJO A;  2Q80 A;  1YYR A;  2Z78 A;  1WL0 A;  4KWD A;  2E8W A;  2Z4Y A;  2OPM A;  5EAT A;  1HXG A;  3UCA A;  3WCC A;  2ZCO A;  3CP6 A;  3B7L A;  3LZ9 A;  4Q23 A;  3DYF A;  3EFQ A;  3VJB A;  3KRA A;  1VG2 A;  1YYT A;  4XQT F;  3TS7 A;  2E4O A;  3WC9 A;  2OGD A;  1N23 A;  3S9V A;  2ZCR A;  3LLW A;  3WCJ A;  3KRO B;  3ZMB A;  4LPG F;  4HD1 A;  1YYU A;  2E92 A;  3M0G A;  3M00 A;  3PYB A;  2AEK A;  4DWG A;  4LOB A;  3WE9 A;  5DJV F;  4OMH A;  4F62 A;  4LTV A;  4KQS A;  5B0K A;  3P41 A;  3PYA A;  2ZY1 A;  5HNA A;  2AEL A;  5IL8 A;  2PS8 A;  4LA5 A;  3LSN A;  5HN7 A;  4LUU A;  1WL3 A;  3S4J A;  2VF6 A;  3Q1O A;  4DWB A;  1N24 A;  4L2X F;  3QKC A;  4NG6 A;  4N9U A;  1V4H A;  2F94 F;  5DGS F;  3G4D A;  5IMI A;  2Z4W A;  2O1O A;  3Q2Z A;  3M9U A;  4QXS F;  1V4E A;  3N5J F;  5JA0 F;  3KRF B;  4OGU A;  1WKZ A;  5A0K A;  4KVD A;  5HN9 A;  1HXC A;  5E8K A;  1YJ4 A;  4PVY F;  4LZ3 A;  5JUZ F;  3ID0 A;  2Q9Z A;  3NF2 A;  5KSX F;  4JYX A;  2PS7 A;  4JZB A;  2E93 A;  4DZW A;  5AYP A;  5CG6 A;  5A0J A;  1VG7 A;  3N1V F;  5H9D A;  3ADZ A;  4GA3 A;  1YYS A;  4E9Z A;  3WEI A;  3OYR A;  3WEH A;  1HXA A;  5ILD A;  3KB9 A;  3N1W F;  2ONG A;  4MC0 A;  4LIX A;  4UMJ A;  3SDV A;  3KRP B;  1VG4 A;  1V4I A;  4KVY A;  3KRC B;  4MC3 A;  3BNX A;  4DXJ A;  4LFE A;  1UBY A;  1V4K A;  3N46 F;  3APZ A;  1HM4 A;  3AQB B;  2I19 A;  4RXC A;  3W7F A;  5AEL A;  1RQI A;  4JXY A;  3N3D A;  3N3L F;  2AZL A;  1N1B A;  1UBV A;  3TC1 A;  3G4F A;  3V1X A;  2F89 F;  2AZJ A;  5IMN A;  2ZEV A;  1DI1 A;  3DYG A;  2Q58 A;  3VJ9 A;  5ILI A;  3ZMC A;  3LMD A;  3IBA A;  4DI5 A;  3VJD A;  5JV1 F;  5B0I A;  5EAS A;  3VJ8 A;  4EA2 A;  1UBW A;  5DHI A;  3V66 A;  3OAC B;  4LLT A;  2F8Z F;  4OKM A;  2DH4 A;  3WCF A;  3OAB B;  5B01 A;  3P5P A;  4RYP A;  5B0L A;  3RBM A;  5ILH A;  3KRP A;  1YHL A;  2Z7H A;  4KVW A;  3LK5 A;  3WCD A;  5DJP F;  3KRC A;  5DJR F;  1JFG A;  4F6V A;  5ER8 A;  1RTR A;  4KKM A;  2Z50 A;  2PS4 A;  4E9U A;  3TFV A;  3SDT A;  3ASX A;  5ERN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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