5JV2F

Crystal structure of human fpps in complex with an allosteric inhibitor mit-01-055
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
341
structure length
331
Chain Sequence
YAQEKQDFVQHFSQIVRVLTEPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Homo sapiens
molecule keywords Farnesyl pyrophosphate synthase
total genus 123
structure length 331
sequence length 341
ec nomenclature ec 2.5.1.1: Dimethylallyltranstransferase.
pdb deposition date 2016-05-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF00348 polyprenyl_synt Polyprenyl synthetase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.600.10 Mainly Alpha Orthogonal Bundle Farnesyl Diphosphate Synthase Farnesyl Diphosphate Synthase 5jv2F00
3LEEA 1V4HA 2Z4ZA 5CG6A 2P1CA 3CC9A 3IPIA 5E8KA 5ILHA 4F6XA 3P8RA 3WEKA 5DGSF 3LMDA 4DXJA 5B0JA 4NKEA 4MC8A 3QQVA 3OABB 2F7MF 3RBMA 5AFXA 5A0IA 5ILIA 3V1XA 1WL0A 3NPRA 2ZY1A 1YJ4A 3CP6A 2O1OA 3WSAA 2AEKA 2Z4YA 5EROA 2F8CF 5HNAA 1YYTA 4NFKF 3PDEA 5DJRF 3WCEA 3N3LF 5IL3A 3NPKA 3V66A 3Q1OA 5AELA 5ILYA 1HXGA 3B7LA 3ID0A 2ZCSA 3TS7A 4E9ZA 4P0VA 5HN7A 1UBWA 4LZCA 2Z7HA 4JXNA 4KK2A 4KQSA 3WCDA 5ILKA 3OACB 3N45F 1KIYA 1YYSA 1VG7A 2ONHA 3ZOUA 3LVSA 3N0FA 5DGMF 4LOBA 2F8ZF 3VJAA 4LUUA 2F89F 3Q2QA 3SDUA 3LSNA 3P5RA 2OPMA 4N1ZF 1ZW5A 3IBAA 3P41A 1WL3A 3AE0A 2J1PA 4E9UA 4NG6A 4DZWA 2E91A 5EAUA 4LPGF 5IK9A 4OGUA 4MC3A 4QXSF 3M9UA 4JVJF 4KWDA 5DHKA 3V1VA 1DGPA 5IK0A 3G4DA 1KIZA 2Z50A 5A0KA 4KVYA 4KKMA 2E8UA 4RNQA 1WL2A 4EA1A 4DEMF 3WE9A 3ICNA 4LFGA 3LGZB 5IKHA 3KBKA 5HN8A 4LTVA 3VJ8A 4DI5A 3LLWA 3OABA 3N5HF 2J5CA 1VG4A 3KRFA 3M01A 3UCAA 3VJ9A 4XQSF 3WEIA 2Z4XA 5DHIA 4P0XA 3AQ0A 3PYBA 5H9DA 4RXCA 2PS4A 1DI1A 1JFAA 2OPNA 3WCAA 2E8XA 3KROA 1UBXA 4JXYA 1N24A 1N20A 2E8WA 3ZCDA 4LA5A 4RXAA 3ZL6A 1VG2A 5E8HA 4NKFA 4RXEA 3SDRA 4LTZA 4PVYF 2RAHA 2F92F 2E8TA 5IMPA 2E93A 3WC9A 4N9UA 3N46F 3OACA 3KRFB 3WJOA 2E95A 4F62A 4GAXA 1WL1A 5B0LA 3RYEA 3BNYA 3KRPB 3WCBA 3WCIA 3VJDA 3SDQA 1RQJA 3KRCB 5DJPF 3WSBA 4GP2A 4KVWA 3KROB 3N1VF 3N0GA 3DYHA 3ICKA 2DH4A 2Q9ZA 4RYPA 5B0MA 5ERNA 4JYXA 2AZJA 1EZFA 3M02A 4Q23A 4KVDA 1VG3A 3LZ9A 1HX9A 1N22A 5IL8A 4OKZA 1YHKA 3APZA 4RXDA 3WCGA 4LFVF 2Q9YA 4NFJF 4LA6A 2Z7IA 4QPFA 4P0WA 2ZEUA 3WJKA 2ZCOA 3LK5A 3Q30A 3ACWA 3ICZA 4KVIA 3N5JF 4KPJA 4LPHF 4LXWA 1UBVA 5B00A 5B0KA 1YYQA 1RTRA 2AZKA 3LJIA 2FTZA 4JZBA 5IMNA 4DHDA 4KFAA 5IN8A 1V4IA 4NFIF 3WCHA 4OKMA 4XQTF 4LIXA 5DIQF 2E90A 1HXCA 5C05A 4LLSA 5I1UA 4XQRF 3ICMA 2FORA 5IMIA 1N1ZA 2PS5A 5DJVF 1N21A 3TFPA 4EA0A 1VG6A 3BNXA 3KRPA 4H5CF 2Z52A 5A0JA 3PH7A 1JFGA 4KQ5A 3NF2A 4DWBA 4MC0A 4F6VA 5KSXF 5DW7A 3MZVA 1V4JA 3KRCA 1HXAA 2VF6A 2AELA 4L2XF 3LOMA 3WCLA 3DYGA 5B01A 3OYRA 5AHUB 2ZCRA 3VJCA 2F94F 3KRAB 3G4FA 2AZLA 3WEHA 3TFNA 2ONGA 5JV1F 2Q58A 4H5DF 3CKEA 3PYAA 3N3DA 3P8LA 3WCFA 4WK5A 1YHMA 2Z4WA 4DWGA 3WEJA 4H5EF 3WCJA 3PKOA 1HM4A 2PS8A 2ZCQA 3QKCA 3EZ3A 1YV5A 5IK6A 5E8LA 3W7FA 5JV2F 3WCMA 4JZXA 2Z4VA 4LFEA 4LZ0A 3WEFA 1YYRA 3M00A 3SDVA 5ERMA 1YHLA 2AETA 5AYPA 3KB9A 5IKAA 3N1WF 4ZQ8A 5ILJA 1YYUA 3P5PA 1WY0A 3EGTA 3ACXA 1V4EA 5JV0F 2F9KF 3S4JA 2EWGA 3MAVA 3ASXA 5JUZF 1WKZA 5ER8A 5IVGA 4KQUA 3RYWA 2OGDA 3VJEA 4GP1A 1PS1A 5EATA 4EA2A 5EASA 3LGKA 3EFQA 3TFVA 3ZMCA 4KUXA 3ZMBA 4NUAA 2E8VA 4FJQA 3AQCB 5B0IA 3RMGA 1RQIA 3VJBA 4HD1A 2Q80A 5HN9A 5IM1A 2ZEVA 2E4OA 2H8OA 4LZ3A 2PS7A 3SAEA 4K10A 4GA3A 1YQ7A 2I19A 3DYFA 3N6KF 3WEGA 4LLTA 2Z78A 5DZ2A 3KRAA 1N23A 2E94A 1HM7A 3SDTA 5B02A 3NRIA 2QISA 3Q2ZA 2OA6A 5DGNF 3ADZA 3ACYA 4OMHA 4KPDA 3S9VA 1V4KA 5JA0F 3TC1A 3M0GA 2PS6A 3LDWA 4OMGA 5CG5A 5ILZA 5B03A 1UBYA 2J1OA 4UMJA 3N49F 1FPSA 2E92A 3WJNA 5ILDA 3LG5A 4PVXF 3WCCA 4FP4A 4E1EA 1N1BA 3AQBB 1WMWA
chains in the Genus database with same CATH superfamily
3LEEA 1V4HA 2Z4ZA 5CG6A 2P1CA 3CC9A 3IPIA 5E8KA 5ILHA 4F6XA 3P8RA 3WEKA 5DGSF 3LMDA 4DXJA 5B0JA 4NKEA 4MC8A 3QQVA 3OABB 2F7MF 3RBMA 5AFXA 5A0IA 5ILIA 3V1XA 1WL0A 3NPRA 2ZY1A 1YJ4A 3CP6A 2O1OA 3WSAA 2AEKA 2Z4YA 5EROA 2F8CF 5HNAA 1YYTA 4NFKF 3PDEA 5DJRF 3WCEA 3N3LF 5IL3A 3NPKA 3V66A 3Q1OA 5AELA 5ILYA 1HXGA 3B7LA 3ID0A 2ZCSA 3TS7A 4E9ZA 4P0VA 5HN7A 1UBWA 4LZCA 2Z7HA 4JXNA 4KK2A 4KQSA 3WCDA 5ILKA 3OACB 3N45F 1KIYA 1YYSA 1VG7A 2ONHA 3ZOUA 3LVSA 3N0FA 5DGMF 4LOBA 2F8ZF 3VJAA 4LUUA 2F89F 3Q2QA 3SDUA 3LSNA 3P5RA 2OPMA 4N1ZF 1ZW5A 3IBAA 3P41A 1WL3A 3AE0A 2J1PA 4E9UA 4NG6A 4DZWA 2E91A 5EAUA 4LPGF 5IK9A 4OGUA 4MC3A 4QXSF 3M9UA 4JVJF 4KWDA 5DHKA 3V1VA 1DGPA 5IK0A 3G4DA 1KIZA 2Z50A 5A0KA 4KVYA 4KKMA 2E8UA 4RNQA 1WL2A 4EA1A 4DEMF 3WE9A 3ICNA 4LFGA 3LGZB 5IKHA 3KBKA 5HN8A 4LTVA 3VJ8A 4DI5A 3LLWA 3OABA 3N5HF 2J5CA 1VG4A 3KRFA 3M01A 3UCAA 3VJ9A 4XQSF 3WEIA 2Z4XA 5DHIA 4P0XA 3AQ0A 3PYBA 5H9DA 4RXCA 2PS4A 1DI1A 1JFAA 2OPNA 3WCAA 2E8XA 3KROA 1UBXA 4JXYA 1N24A 1N20A 2E8WA 3ZCDA 4LA5A 4RXAA 3ZL6A 1VG2A 5E8HA 4NKFA 4RXEA 3SDRA 4LTZA 4PVYF 2RAHA 2F92F 2E8TA 5IMPA 2E93A 3WC9A 4N9UA 3N46F 3OACA 3KRFB 3WJOA 2E95A 4F62A 4GAXA 1WL1A 5B0LA 3RYEA 3BNYA 3KRPB 3WCBA 3WCIA 3VJDA 3SDQA 1RQJA 3KRCB 5DJPF 3WSBA 4GP2A 4KVWA 3KROB 3N1VF 3N0GA 3DYHA 3ICKA 2DH4A 2Q9ZA 4RYPA 5B0MA 5ERNA 4JYXA 2AZJA 1EZFA 3M02A 4Q23A 4KVDA 1VG3A 3LZ9A 1HX9A 1N22A 5IL8A 4OKZA 1YHKA 3APZA 4RXDA 3WCGA 4LFVF 2Q9YA 4NFJF 4LA6A 2Z7IA 4QPFA 4P0WA 2ZEUA 3WJKA 2ZCOA 3LK5A 3Q30A 3ACWA 3ICZA 4KVIA 3N5JF 4KPJA 4LPHF 4LXWA 1UBVA 5B00A 5B0KA 1YYQA 1RTRA 2AZKA 3LJIA 2FTZA 4JZBA 5IMNA 4DHDA 4KFAA 5IN8A 1V4IA 4NFIF 3WCHA 4OKMA 4XQTF 4LIXA 5DIQF 2E90A 1HXCA 5C05A 4LLSA 5I1UA 4XQRF 3ICMA 2FORA 5IMIA 1N1ZA 2PS5A 5DJVF 1N21A 3TFPA 4EA0A 1VG6A 3BNXA 3KRPA 4H5CF 2Z52A 5A0JA 3PH7A 1JFGA 4KQ5A 3NF2A 4DWBA 4MC0A 4F6VA 5KSXF 5DW7A 3MZVA 1V4JA 3KRCA 1HXAA 2VF6A 2AELA 4L2XF 3LOMA 3WCLA 3DYGA 5B01A 3OYRA 5AHUB 2ZCRA 3VJCA 2F94F 3KRAB 3G4FA 2AZLA 3WEHA 3TFNA 2ONGA 5JV1F 2Q58A 4H5DF 3CKEA 3PYAA 3N3DA 3P8LA 3WCFA 4WK5A 1YHMA 2Z4WA 4DWGA 3WEJA 4H5EF 3WCJA 3PKOA 1HM4A 2PS8A 2ZCQA 3QKCA 3EZ3A 1YV5A 5IK6A 5E8LA 3W7FA 5JV2F 3WCMA 4JZXA 2Z4VA 4LFEA 4LZ0A 3WEFA 1YYRA 3M00A 3SDVA 5ERMA 1YHLA 2AETA 5AYPA 3KB9A 5IKAA 3N1WF 4ZQ8A 5ILJA 1YYUA 3P5PA 1WY0A 3EGTA 3ACXA 1V4EA 5JV0F 2F9KF 3S4JA 2EWGA 3MAVA 3ASXA 5JUZF 1WKZA 5ER8A 5IVGA 4KQUA 3RYWA 2OGDA 3VJEA 4GP1A 1PS1A 5EATA 4EA2A 5EASA 3LGKA 3EFQA 3TFVA 3ZMCA 4KUXA 3ZMBA 4NUAA 2E8VA 4FJQA 3AQCB 5B0IA 3RMGA 1RQIA 3VJBA 4HD1A 2Q80A 5HN9A 5IM1A 2ZEVA 2E4OA 2H8OA 4LZ3A 2PS7A 3SAEA 4K10A 4GA3A 1YQ7A 2I19A 3DYFA 3N6KF 3WEGA 4LLTA 2Z78A 5DZ2A 3KRAA 1N23A 2E94A 1HM7A 3SDTA 5B02A 3NRIA 2QISA 3Q2ZA 2OA6A 5DGNF 3ADZA 3ACYA 4OMHA 4KPDA 3S9VA 1V4KA 5JA0F 3TC1A 3M0GA 2PS6A 3LDWA 4OMGA 5CG5A 5ILZA 5B03A 1UBYA 2J1OA 4UMJA 3N49F 1FPSA 2E92A 3WJNA 5ILDA 3LG5A 4PVXF 3WCCA 4FP4A 4E1EA 1N1BA 3AQBB 1WMWA
chains in the Genus database with same CATH topology
3LEEA 1V4HA 2Z4ZA 5CG6A 2P1CA 3CC9A 3IPIA 5E8KA 5ILHA 4F6XA 3P8RA 3WEKA 5DGSF 3LMDA 4DXJA 5B0JA 4NKEA 4MC8A 3QQVA 3OABB 2F7MF 3RBMA 5AFXA 5A0IA 5ILIA 3V1XA 1WL0A 3NPRA 2ZY1A 1YJ4A 3CP6A 2O1OA 3WSAA 2AEKA 2Z4YA 5EROA 2F8CF 5HNAA 1YYTA 4NFKF 3PDEA 5DJRF 3WCEA 3N3LF 5IL3A 3NPKA 3V66A 3Q1OA 5AELA 5ILYA 1HXGA 3B7LA 3ID0A 2ZCSA 3TS7A 4E9ZA 4P0VA 5HN7A 1UBWA 4LZCA 2Z7HA 4JXNA 4KK2A 4KQSA 3WCDA 5ILKA 3OACB 3N45F 1KIYA 1YYSA 1VG7A 2ONHA 3ZOUA 3LVSA 3N0FA 5DGMF 4LOBA 2F8ZF 3VJAA 4LUUA 2F89F 3Q2QA 3SDUA 3LSNA 3P5RA 2OPMA 4N1ZF 1ZW5A 3IBAA 3P41A 1WL3A 3AE0A 2J1PA 4E9UA 4NG6A 4DZWA 2E91A 5EAUA 4LPGF 5IK9A 4OGUA 4MC3A 4QXSF 3M9UA 4JVJF 4KWDA 5DHKA 3V1VA 1DGPA 5IK0A 3G4DA 1KIZA 2Z50A 5A0KA 4KVYA 4KKMA 2E8UA 4RNQA 1WL2A 4EA1A 4DEMF 3WE9A 3ICNA 4LFGA 3LGZB 5IKHA 3KBKA 5HN8A 4LTVA 3VJ8A 4DI5A 3LLWA 3OABA 3N5HF 2J5CA 1VG4A 3KRFA 3M01A 3UCAA 3VJ9A 4XQSF 3WEIA 2Z4XA 5DHIA 4P0XA 3AQ0A 3PYBA 5H9DA 4RXCA 2PS4A 1DI1A 1JFAA 2OPNA 3WCAA 2E8XA 3KROA 1UBXA 4JXYA 1N24A 1N20A 2E8WA 3ZCDA 4LA5A 4RXAA 3ZL6A 1VG2A 5E8HA 4NKFA 4RXEA 3SDRA 4LTZA 4PVYF 2RAHA 2F92F 2E8TA 5IMPA 2E93A 3WC9A 4N9UA 3N46F 3OACA 3KRFB 3WJOA 2E95A 4F62A 4GAXA 1WL1A 5B0LA 3RYEA 3BNYA 3KRPB 3WCBA 3WCIA 3VJDA 3SDQA 1RQJA 3KRCB 5DJPF 3WSBA 4GP2A 4KVWA 3KROB 3N1VF 3N0GA 3DYHA 3ICKA 2DH4A 2Q9ZA 4RYPA 5B0MA 5ERNA 4JYXA 2AZJA 1EZFA 3M02A 4Q23A 4KVDA 1VG3A 3LZ9A 1HX9A 1N22A 5IL8A 4OKZA 1YHKA 3APZA 4RXDA 3WCGA 4LFVF 2Q9YA 4NFJF 4LA6A 2Z7IA 4QPFA 4P0WA 2ZEUA 3WJKA 2ZCOA 3LK5A 3Q30A 3ACWA 3ICZA 4KVIA 3N5JF 4KPJA 4LPHF 4LXWA 1UBVA 5B00A 5B0KA 1YYQA 1RTRA 2AZKA 3LJIA 2FTZA 4JZBA 5IMNA 4DHDA 4KFAA 5IN8A 1V4IA 4NFIF 3WCHA 4OKMA 4XQTF 4LIXA 5DIQF 2E90A 1HXCA 5C05A 4LLSA 5I1UA 4XQRF 3ICMA 2FORA 5IMIA 1N1ZA 2PS5A 5DJVF 1N21A 3TFPA 4EA0A 1VG6A 3BNXA 3KRPA 4H5CF 2Z52A 5A0JA 3PH7A 1JFGA 4KQ5A 3NF2A 4DWBA 4MC0A 4F6VA 5KSXF 5DW7A 3MZVA 1V4JA 3KRCA 1HXAA 2VF6A 2AELA 4L2XF 3LOMA 3WCLA 3DYGA 5B01A 3OYRA 5AHUB 2ZCRA 3VJCA 2F94F 3KRAB 3G4FA 2AZLA 3WEHA 3TFNA 2ONGA 5JV1F 2Q58A 4H5DF 3CKEA 3PYAA 3N3DA 3P8LA 3WCFA 4WK5A 1YHMA 2Z4WA 4DWGA 3WEJA 4H5EF 3WCJA 3PKOA 1HM4A 2PS8A 2ZCQA 3QKCA 3EZ3A 1YV5A 5IK6A 5E8LA 3W7FA 5JV2F 3WCMA 4JZXA 2Z4VA 4LFEA 4LZ0A 3WEFA 1YYRA 3M00A 3SDVA 5ERMA 1YHLA 2AETA 5AYPA 3KB9A 5IKAA 3N1WF 4ZQ8A 5ILJA 1YYUA 3P5PA 1WY0A 3EGTA 3ACXA 1V4EA 5JV0F 2F9KF 3S4JA 2EWGA 3MAVA 3ASXA 5JUZF 1WKZA 5ER8A 5IVGA 4KQUA 3RYWA 2OGDA 3VJEA 4GP1A 1PS1A 5EATA 4EA2A 5EASA 3LGKA 3EFQA 3TFVA 3ZMCA 4KUXA 3ZMBA 4NUAA 2E8VA 4FJQA 3AQCB 5B0IA 3RMGA 1RQIA 3VJBA 4HD1A 2Q80A 5HN9A 5IM1A 2ZEVA 2E4OA 2H8OA 4LZ3A 2PS7A 3SAEA 4K10A 4GA3A 1YQ7A 2I19A 3DYFA 3N6KF 3WEGA 4LLTA 2Z78A 5DZ2A 3KRAA 1N23A 2E94A 1HM7A 3SDTA 5B02A 3NRIA 2QISA 3Q2ZA 2OA6A 5DGNF 3ADZA 3ACYA 4OMHA 4KPDA 3S9VA 1V4KA 5JA0F 3TC1A 3M0GA 2PS6A 3LDWA 4OMGA 5CG5A 5ILZA 5B03A 1UBYA 2J1OA 4UMJA 3N49F 1FPSA 2E92A 3WJNA 5ILDA 3LG5A 4PVXF 3WCCA 4FP4A 4E1EA 1N1BA 3AQBB 1WMWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LEE A;  1V4H A;  2Z4Z A;  5CG6 A;  2P1C A;  3CC9 A;  3IPI A;  5E8K A;  5ILH A;  4F6X A;  3P8R A;  3WEK A;  5DGS F;  3LMD A;  4DXJ A;  5B0J A;  4NKE A;  4MC8 A;  3QQV A;  3OAB B;  2F7M F;  3RBM A;  5AFX A;  5A0I A;  5ILI A;  3V1X A;  1WL0 A;  3NPR A;  2ZY1 A;  1YJ4 A;  3CP6 A;  2O1O A;  3WSA A;  2AEK A;  2Z4Y A;  5ERO A;  2F8C F;  5HNA A;  1YYT A;  4NFK F;  3PDE A;  5DJR F;  3WCE A;  3N3L F;  5IL3 A;  3NPK A;  3V66 A;  3Q1O A;  5AEL A;  5ILY A;  1HXG A;  3B7L A;  3ID0 A;  2ZCS A;  3TS7 A;  4E9Z A;  4P0V A;  5HN7 A;  1UBW A;  4LZC A;  2Z7H A;  4JXN A;  4KK2 A;  4KQS A;  3WCD A;  5ILK A;  3OAC B;  3N45 F;  1KIY A;  1YYS A;  1VG7 A;  2ONH A;  3ZOU A;  3LVS A;  3N0F A;  5DGM F;  4LOB A;  2F8Z F;  3VJA A;  4LUU A;  2F89 F;  3Q2Q A;  3SDU A;  3LSN A;  3P5R A;  2OPM A;  4N1Z F;  1ZW5 A;  3IBA A;  3P41 A;  1WL3 A;  3AE0 A;  2J1P A;  4E9U A;  4NG6 A;  4DZW A;  2E91 A;  5EAU A;  4LPG F;  5IK9 A;  4OGU A;  4MC3 A;  4QXS F;  3M9U A;  4JVJ F;  4KWD A;  5DHK A;  3V1V A;  1DGP A;  5IK0 A;  3G4D A;  1KIZ A;  2Z50 A;  5A0K A;  4KVY A;  4KKM A;  2E8U A;  4RNQ A;  1WL2 A;  4EA1 A;  4DEM F;  3WE9 A;  3ICN A;  4LFG A;  3LGZ B;  5IKH A;  3KBK A;  5HN8 A;  4LTV A;  3VJ8 A;  4DI5 A;  3LLW A;  3OAB A;  3N5H F;  2J5C A;  1VG4 A;  3KRF A;  3M01 A;  3UCA A;  3VJ9 A;  4XQS F;  3WEI A;  2Z4X A;  5DHI A;  4P0X A;  3AQ0 A;  3PYB A;  5H9D A;  4RXC A;  2PS4 A;  1DI1 A;  1JFA A;  2OPN A;  3WCA A;  2E8X A;  3KRO A;  1UBX A;  4JXY A;  1N24 A;  1N20 A;  2E8W A;  3ZCD A;  4LA5 A;  4RXA A;  3ZL6 A;  1VG2 A;  5E8H A;  4NKF A;  4RXE A;  3SDR A;  4LTZ A;  4PVY F;  2RAH A;  2F92 F;  2E8T A;  5IMP A;  2E93 A;  3WC9 A;  4N9U A;  3N46 F;  3OAC A;  3KRF B;  3WJO A;  2E95 A;  4F62 A;  4GAX A;  1WL1 A;  5B0L A;  3RYE A;  3BNY A;  3KRP B;  3WCB A;  3WCI A;  3VJD A;  3SDQ A;  1RQJ A;  3KRC B;  5DJP F;  3WSB A;  4GP2 A;  4KVW A;  3KRO B;  3N1V F;  3N0G A;  3DYH A;  3ICK A;  2DH4 A;  2Q9Z A;  4RYP A;  5B0M A;  5ERN A;  4JYX A;  2AZJ A;  1EZF A;  3M02 A;  4Q23 A;  4KVD A;  1VG3 A;  3LZ9 A;  1HX9 A;  1N22 A;  5IL8 A;  4OKZ A;  1YHK A;  3APZ A;  4RXD A;  3WCG A;  4LFV F;  2Q9Y A;  4NFJ F;  4LA6 A;  2Z7I A;  4QPF A;  4P0W A;  2ZEU A;  3WJK A;  2ZCO A;  3LK5 A;  3Q30 A;  3ACW A;  3ICZ A;  4KVI A;  3N5J F;  4KPJ A;  4LPH F;  4LXW A;  1UBV A;  5B00 A;  5B0K A;  1YYQ A;  1RTR A;  2AZK A;  3LJI A;  2FTZ A;  4JZB A;  5IMN A;  4DHD A;  4KFA A;  5IN8 A;  1V4I A;  4NFI F;  3WCH A;  4OKM A;  4XQT F;  4LIX A;  5DIQ F;  2E90 A;  1HXC A;  5C05 A;  4LLS A;  5I1U A;  4XQR F;  3ICM A;  2FOR A;  5IMI A;  1N1Z A;  2PS5 A;  5DJV F;  1N21 A;  3TFP A;  4EA0 A;  1VG6 A;  3BNX A;  3KRP A;  4H5C F;  2Z52 A;  5A0J A;  3PH7 A;  1JFG A;  4KQ5 A;  3NF2 A;  4DWB A;  4MC0 A;  4F6V A;  5KSX F;  5DW7 A;  3MZV A;  1V4J A;  3KRC A;  1HXA A;  2VF6 A;  2AEL A;  4L2X F;  3LOM A;  3WCL A;  3DYG A;  5B01 A;  3OYR A;  5AHU B;  2ZCR A;  3VJC A;  2F94 F;  3KRA B;  3G4F A;  2AZL A;  3WEH A;  3TFN A;  2ONG A;  5JV1 F;  2Q58 A;  4H5D F;  3CKE A;  3PYA A;  3N3D A;  3P8L A;  3WCF A;  4WK5 A;  1YHM A;  2Z4W A;  4DWG A;  3WEJ A;  4H5E F;  3WCJ A;  3PKO A;  1HM4 A;  2PS8 A;  2ZCQ A;  3QKC A;  3EZ3 A;  1YV5 A;  5IK6 A;  5E8L A;  3W7F A;  5JV2 F;  3WCM A;  4JZX A;  2Z4V A;  4LFE A;  4LZ0 A;  3WEF A;  1YYR A;  3M00 A;  3SDV A;  5ERM A;  1YHL A;  2AET A;  5AYP A;  3KB9 A;  5IKA A;  3N1W F;  4ZQ8 A;  5ILJ A;  1YYU A;  3P5P A;  1WY0 A;  3EGT A;  3ACX A;  1V4E A;  5JV0 F;  2F9K F;  3S4J A;  2EWG A;  3MAV A;  3ASX A;  5JUZ F;  1WKZ A;  5ER8 A;  5IVG A;  4KQU A;  3RYW A;  2OGD A;  3VJE A;  4GP1 A;  1PS1 A;  5EAT A;  4EA2 A;  5EAS A;  3LGK A;  3EFQ A;  3TFV A;  3ZMC A;  4KUX A;  3ZMB A;  4NUA A;  2E8V A;  4FJQ A;  3AQC B;  5B0I A;  3RMG A;  1RQI A;  3VJB A;  4HD1 A;  2Q80 A;  5HN9 A;  5IM1 A;  2ZEV A;  2E4O A;  2H8O A;  4LZ3 A;  2PS7 A;  3SAE A;  4K10 A;  4GA3 A;  1YQ7 A;  2I19 A;  3DYF A;  3N6K F;  3WEG A;  4LLT A;  2Z78 A;  5DZ2 A;  3KRA A;  1N23 A;  2E94 A;  1HM7 A;  3SDT A;  5B02 A;  3NRI A;  2QIS A;  3Q2Z A;  2OA6 A;  5DGN F;  3ADZ A;  3ACY A;  4OMH A;  4KPD A;  3S9V A;  1V4K A;  5JA0 F;  3TC1 A;  3M0G A;  2PS6 A;  3LDW A;  4OMG A;  5CG5 A;  5ILZ A;  5B03 A;  1UBY A;  2J1O A;  4UMJ A;  3N49 F;  1FPS A;  2E92 A;  3WJN A;  5ILD A;  3LG5 A;  4PVX F;  3WCC A;  4FP4 A;  4E1E A;  1N1B A;  3AQB B;  1WMW A; 
#chains in the Genus database with same CATH topology
 3LEE A;  1V4H A;  2Z4Z A;  5CG6 A;  2P1C A;  3CC9 A;  3IPI A;  5E8K A;  5ILH A;  4F6X A;  3P8R A;  3WEK A;  5DGS F;  3LMD A;  4DXJ A;  5B0J A;  4NKE A;  4MC8 A;  3QQV A;  3OAB B;  2F7M F;  3RBM A;  5AFX A;  5A0I A;  5ILI A;  3V1X A;  1WL0 A;  3NPR A;  2ZY1 A;  1YJ4 A;  3CP6 A;  2O1O A;  3WSA A;  2AEK A;  2Z4Y A;  5ERO A;  2F8C F;  5HNA A;  1YYT A;  4NFK F;  3PDE A;  5DJR F;  3WCE A;  3N3L F;  5IL3 A;  3NPK A;  3V66 A;  3Q1O A;  5AEL A;  5ILY A;  1HXG A;  3B7L A;  3ID0 A;  2ZCS A;  3TS7 A;  4E9Z A;  4P0V A;  5HN7 A;  1UBW A;  4LZC A;  2Z7H A;  4JXN A;  4KK2 A;  4KQS A;  3WCD A;  5ILK A;  3OAC B;  3N45 F;  1KIY A;  1YYS A;  1VG7 A;  2ONH A;  3ZOU A;  3LVS A;  3N0F A;  5DGM F;  4LOB A;  2F8Z F;  3VJA A;  4LUU A;  2F89 F;  3Q2Q A;  3SDU A;  3LSN A;  3P5R A;  2OPM A;  4N1Z F;  1ZW5 A;  3IBA A;  3P41 A;  1WL3 A;  3AE0 A;  2J1P A;  4E9U A;  4NG6 A;  4DZW A;  2E91 A;  5EAU A;  4LPG F;  5IK9 A;  4OGU A;  4MC3 A;  4QXS F;  3M9U A;  4JVJ F;  4KWD A;  5DHK A;  3V1V A;  1DGP A;  5IK0 A;  3G4D A;  1KIZ A;  2Z50 A;  5A0K A;  4KVY A;  4KKM A;  2E8U A;  4RNQ A;  1WL2 A;  4EA1 A;  4DEM F;  3WE9 A;  3ICN A;  4LFG A;  3LGZ B;  5IKH A;  3KBK A;  5HN8 A;  4LTV A;  3VJ8 A;  4DI5 A;  3LLW A;  3OAB A;  3N5H F;  2J5C A;  1VG4 A;  3KRF A;  3M01 A;  3UCA A;  3VJ9 A;  4XQS F;  3WEI A;  2Z4X A;  5DHI A;  4P0X A;  3AQ0 A;  3PYB A;  5H9D A;  4RXC A;  2PS4 A;  1DI1 A;  1JFA A;  2OPN A;  3WCA A;  2E8X A;  3KRO A;  1UBX A;  4JXY A;  1N24 A;  1N20 A;  2E8W A;  3ZCD A;  4LA5 A;  4RXA A;  3ZL6 A;  1VG2 A;  5E8H A;  4NKF A;  4RXE A;  3SDR A;  4LTZ A;  4PVY F;  2RAH A;  2F92 F;  2E8T A;  5IMP A;  2E93 A;  3WC9 A;  4N9U A;  3N46 F;  3OAC A;  3KRF B;  3WJO A;  2E95 A;  4F62 A;  4GAX A;  1WL1 A;  5B0L A;  3RYE A;  3BNY A;  3KRP B;  3WCB A;  3WCI A;  3VJD A;  3SDQ A;  1RQJ A;  3KRC B;  5DJP F;  3WSB A;  4GP2 A;  4KVW A;  3KRO B;  3N1V F;  3N0G A;  3DYH A;  3ICK A;  2DH4 A;  2Q9Z A;  4RYP A;  5B0M A;  5ERN A;  4JYX A;  2AZJ A;  1EZF A;  3M02 A;  4Q23 A;  4KVD A;  1VG3 A;  3LZ9 A;  1HX9 A;  1N22 A;  5IL8 A;  4OKZ A;  1YHK A;  3APZ A;  4RXD A;  3WCG A;  4LFV F;  2Q9Y A;  4NFJ F;  4LA6 A;  2Z7I A;  4QPF A;  4P0W A;  2ZEU A;  3WJK A;  2ZCO A;  3LK5 A;  3Q30 A;  3ACW A;  3ICZ A;  4KVI A;  3N5J F;  4KPJ A;  4LPH F;  4LXW A;  1UBV A;  5B00 A;  5B0K A;  1YYQ A;  1RTR A;  2AZK A;  3LJI A;  2FTZ A;  4JZB A;  5IMN A;  4DHD A;  4KFA A;  5IN8 A;  1V4I A;  4NFI F;  3WCH A;  4OKM A;  4XQT F;  4LIX A;  5DIQ F;  2E90 A;  1HXC A;  5C05 A;  4LLS A;  5I1U A;  4XQR F;  3ICM A;  2FOR A;  5IMI A;  1N1Z A;  2PS5 A;  5DJV F;  1N21 A;  3TFP A;  4EA0 A;  1VG6 A;  3BNX A;  3KRP A;  4H5C F;  2Z52 A;  5A0J A;  3PH7 A;  1JFG A;  4KQ5 A;  3NF2 A;  4DWB A;  4MC0 A;  4F6V A;  5KSX F;  5DW7 A;  3MZV A;  1V4J A;  3KRC A;  1HXA A;  2VF6 A;  2AEL A;  4L2X F;  3LOM A;  3WCL A;  3DYG A;  5B01 A;  3OYR A;  5AHU B;  2ZCR A;  3VJC A;  2F94 F;  3KRA B;  3G4F A;  2AZL A;  3WEH A;  3TFN A;  2ONG A;  5JV1 F;  2Q58 A;  4H5D F;  3CKE A;  3PYA A;  3N3D A;  3P8L A;  3WCF A;  4WK5 A;  1YHM A;  2Z4W A;  4DWG A;  3WEJ A;  4H5E F;  3WCJ A;  3PKO A;  1HM4 A;  2PS8 A;  2ZCQ A;  3QKC A;  3EZ3 A;  1YV5 A;  5IK6 A;  5E8L A;  3W7F A;  5JV2 F;  3WCM A;  4JZX A;  2Z4V A;  4LFE A;  4LZ0 A;  3WEF A;  1YYR A;  3M00 A;  3SDV A;  5ERM A;  1YHL A;  2AET A;  5AYP A;  3KB9 A;  5IKA A;  3N1W F;  4ZQ8 A;  5ILJ A;  1YYU A;  3P5P A;  1WY0 A;  3EGT A;  3ACX A;  1V4E A;  5JV0 F;  2F9K F;  3S4J A;  2EWG A;  3MAV A;  3ASX A;  5JUZ F;  1WKZ A;  5ER8 A;  5IVG A;  4KQU A;  3RYW A;  2OGD A;  3VJE A;  4GP1 A;  1PS1 A;  5EAT A;  4EA2 A;  5EAS A;  3LGK A;  3EFQ A;  3TFV A;  3ZMC A;  4KUX A;  3ZMB A;  4NUA A;  2E8V A;  4FJQ A;  3AQC B;  5B0I A;  3RMG A;  1RQI A;  3VJB A;  4HD1 A;  2Q80 A;  5HN9 A;  5IM1 A;  2ZEV A;  2E4O A;  2H8O A;  4LZ3 A;  2PS7 A;  3SAE A;  4K10 A;  4GA3 A;  1YQ7 A;  2I19 A;  3DYF A;  3N6K F;  3WEG A;  4LLT A;  2Z78 A;  5DZ2 A;  3KRA A;  1N23 A;  2E94 A;  1HM7 A;  3SDT A;  5B02 A;  3NRI A;  2QIS A;  3Q2Z A;  2OA6 A;  5DGN F;  3ADZ A;  3ACY A;  4OMH A;  4KPD A;  3S9V A;  1V4K A;  5JA0 F;  3TC1 A;  3M0G A;  2PS6 A;  3LDW A;  4OMG A;  5CG5 A;  5ILZ A;  5B03 A;  1UBY A;  2J1O A;  4UMJ A;  3N49 F;  1FPS A;  2E92 A;  3WJN A;  5ILD A;  3LG5 A;  4PVX F;  3WCC A;  4FP4 A;  4E1E A;  1N1B A;  3AQB B;  1WMW A; 
#chains in the Genus database with same CATH homology
 3LEE A;  1V4H A;  2Z4Z A;  5CG6 A;  2P1C A;  3CC9 A;  3IPI A;  5E8K A;  5ILH A;  4F6X A;  3P8R A;  3WEK A;  5DGS F;  3LMD A;  4DXJ A;  5B0J A;  4NKE A;  4MC8 A;  3QQV A;  3OAB B;  2F7M F;  3RBM A;  5AFX A;  5A0I A;  5ILI A;  3V1X A;  1WL0 A;  3NPR A;  2ZY1 A;  1YJ4 A;  3CP6 A;  2O1O A;  3WSA A;  2AEK A;  2Z4Y A;  5ERO A;  2F8C F;  5HNA A;  1YYT A;  4NFK F;  3PDE A;  5DJR F;  3WCE A;  3N3L F;  5IL3 A;  3NPK A;  3V66 A;  3Q1O A;  5AEL A;  5ILY A;  1HXG A;  3B7L A;  3ID0 A;  2ZCS A;  3TS7 A;  4E9Z A;  4P0V A;  5HN7 A;  1UBW A;  4LZC A;  2Z7H A;  4JXN A;  4KK2 A;  4KQS A;  3WCD A;  5ILK A;  3OAC B;  3N45 F;  1KIY A;  1YYS A;  1VG7 A;  2ONH A;  3ZOU A;  3LVS A;  3N0F A;  5DGM F;  4LOB A;  2F8Z F;  3VJA A;  4LUU A;  2F89 F;  3Q2Q A;  3SDU A;  3LSN A;  3P5R A;  2OPM A;  4N1Z F;  1ZW5 A;  3IBA A;  3P41 A;  1WL3 A;  3AE0 A;  2J1P A;  4E9U A;  4NG6 A;  4DZW A;  2E91 A;  5EAU A;  4LPG F;  5IK9 A;  4OGU A;  4MC3 A;  4QXS F;  3M9U A;  4JVJ F;  4KWD A;  5DHK A;  3V1V A;  1DGP A;  5IK0 A;  3G4D A;  1KIZ A;  2Z50 A;  5A0K A;  4KVY A;  4KKM A;  2E8U A;  4RNQ A;  1WL2 A;  4EA1 A;  4DEM F;  3WE9 A;  3ICN A;  4LFG A;  3LGZ B;  5IKH A;  3KBK A;  5HN8 A;  4LTV A;  3VJ8 A;  4DI5 A;  3LLW A;  3OAB A;  3N5H F;  2J5C A;  1VG4 A;  3KRF A;  3M01 A;  3UCA A;  3VJ9 A;  4XQS F;  3WEI A;  2Z4X A;  5DHI A;  4P0X A;  3AQ0 A;  3PYB A;  5H9D A;  4RXC A;  2PS4 A;  1DI1 A;  1JFA A;  2OPN A;  3WCA A;  2E8X A;  3KRO A;  1UBX A;  4JXY A;  1N24 A;  1N20 A;  2E8W A;  3ZCD A;  4LA5 A;  4RXA A;  3ZL6 A;  1VG2 A;  5E8H A;  4NKF A;  4RXE A;  3SDR A;  4LTZ A;  4PVY F;  2RAH A;  2F92 F;  2E8T A;  5IMP A;  2E93 A;  3WC9 A;  4N9U A;  3N46 F;  3OAC A;  3KRF B;  3WJO A;  2E95 A;  4F62 A;  4GAX A;  1WL1 A;  5B0L A;  3RYE A;  3BNY A;  3KRP B;  3WCB A;  3WCI A;  3VJD A;  3SDQ A;  1RQJ A;  3KRC B;  5DJP F;  3WSB A;  4GP2 A;  4KVW A;  3KRO B;  3N1V F;  3N0G A;  3DYH A;  3ICK A;  2DH4 A;  2Q9Z A;  4RYP A;  5B0M A;  5ERN A;  4JYX A;  2AZJ A;  1EZF A;  3M02 A;  4Q23 A;  4KVD A;  1VG3 A;  3LZ9 A;  1HX9 A;  1N22 A;  5IL8 A;  4OKZ A;  1YHK A;  3APZ A;  4RXD A;  3WCG A;  4LFV F;  2Q9Y A;  4NFJ F;  4LA6 A;  2Z7I A;  4QPF A;  4P0W A;  2ZEU A;  3WJK A;  2ZCO A;  3LK5 A;  3Q30 A;  3ACW A;  3ICZ A;  4KVI A;  3N5J F;  4KPJ A;  4LPH F;  4LXW A;  1UBV A;  5B00 A;  5B0K A;  1YYQ A;  1RTR A;  2AZK A;  3LJI A;  2FTZ A;  4JZB A;  5IMN A;  4DHD A;  4KFA A;  5IN8 A;  1V4I A;  4NFI F;  3WCH A;  4OKM A;  4XQT F;  4LIX A;  5DIQ F;  2E90 A;  1HXC A;  5C05 A;  4LLS A;  5I1U A;  4XQR F;  3ICM A;  2FOR A;  5IMI A;  1N1Z A;  2PS5 A;  5DJV F;  1N21 A;  3TFP A;  4EA0 A;  1VG6 A;  3BNX A;  3KRP A;  4H5C F;  2Z52 A;  5A0J A;  3PH7 A;  1JFG A;  4KQ5 A;  3NF2 A;  4DWB A;  4MC0 A;  4F6V A;  5KSX F;  5DW7 A;  3MZV A;  1V4J A;  3KRC A;  1HXA A;  2VF6 A;  2AEL A;  4L2X F;  3LOM A;  3WCL A;  3DYG A;  5B01 A;  3OYR A;  5AHU B;  2ZCR A;  3VJC A;  2F94 F;  3KRA B;  3G4F A;  2AZL A;  3WEH A;  3TFN A;  2ONG A;  5JV1 F;  2Q58 A;  4H5D F;  3CKE A;  3PYA A;  3N3D A;  3P8L A;  3WCF A;  4WK5 A;  1YHM A;  2Z4W A;  4DWG A;  3WEJ A;  4H5E F;  3WCJ A;  3PKO A;  1HM4 A;  2PS8 A;  2ZCQ A;  3QKC A;  3EZ3 A;  1YV5 A;  5IK6 A;  5E8L A;  3W7F A;  5JV2 F;  3WCM A;  4JZX A;  2Z4V A;  4LFE A;  4LZ0 A;  3WEF A;  1YYR A;  3M00 A;  3SDV A;  5ERM A;  1YHL A;  2AET A;  5AYP A;  3KB9 A;  5IKA A;  3N1W F;  4ZQ8 A;  5ILJ A;  1YYU A;  3P5P A;  1WY0 A;  3EGT A;  3ACX A;  1V4E A;  5JV0 F;  2F9K F;  3S4J A;  2EWG A;  3MAV A;  3ASX A;  5JUZ F;  1WKZ A;  5ER8 A;  5IVG A;  4KQU A;  3RYW A;  2OGD A;  3VJE A;  4GP1 A;  1PS1 A;  5EAT A;  4EA2 A;  5EAS A;  3LGK A;  3EFQ A;  3TFV A;  3ZMC A;  4KUX A;  3ZMB A;  4NUA A;  2E8V A;  4FJQ A;  3AQC B;  5B0I A;  3RMG A;  1RQI A;  3VJB A;  4HD1 A;  2Q80 A;  5HN9 A;  5IM1 A;  2ZEV A;  2E4O A;  2H8O A;  4LZ3 A;  2PS7 A;  3SAE A;  4K10 A;  4GA3 A;  1YQ7 A;  2I19 A;  3DYF A;  3N6K F;  3WEG A;  4LLT A;  2Z78 A;  5DZ2 A;  3KRA A;  1N23 A;  2E94 A;  1HM7 A;  3SDT A;  5B02 A;  3NRI A;  2QIS A;  3Q2Z A;  2OA6 A;  5DGN F;  3ADZ A;  3ACY A;  4OMH A;  4KPD A;  3S9V A;  1V4K A;  5JA0 F;  3TC1 A;  3M0G A;  2PS6 A;  3LDW A;  4OMG A;  5CG5 A;  5ILZ A;  5B03 A;  1UBY A;  2J1O A;  4UMJ A;  3N49 F;  1FPS A;  2E92 A;  3WJN A;  5ILD A;  3LG5 A;  4PVX F;  3WCC A;  4FP4 A;  4E1E A;  1N1B A;  3AQB B;  1WMW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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