1FS1A

Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex
Total Genus 11
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
41
structure length
41
Chain Sequence
WDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLW
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
pubmed doi rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords CYCLIN A/CDK2-ASSOCIATED P19
total genus 11
structure length 41
sequence length 41
chains with identical sequence C
ec nomenclature
pdb deposition date 2000-09-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1280.50 Mainly Alpha Up-down Bundle Monooxygenase Monooxygenase 1fs1A00
3C6NB 2P1OB 2E32A 1LDKE 2E31A 3C6OB 1NEXB 2P1PB 3V7DB 2OVRB 3C6PB 3WSOA 1P22A 3MKSB 5IBKB 3L2OB 2P1QB 3OGKB 4I6JB 3OGLB 2OVQB 2OVPB 2P1NB 1FS1A 2P1MB 3OGMB
chains in the Genus database with same CATH superfamily
4M3YA 2LF3A 1FXXA 3QEIA 3LDSA 1XMFE 1FYZE 1FZ6E 2RCUA 3UO3A 1Q9XA 2JH8A 1FZ5E 4E3SA 1XU5E 3RMCA 2P5GA 4DTPA 3TAFA 3N1EA 3C6OB 4RG8A 4FJXA 2DY4A 3HGLA 4X5MA 3RMAA 2OVRB 3C6PB 3QETA 2HD0A 1P22A 3SQ1A 4HCCA 4DTMA 2JHPA 5IREA 1XVEE 4FJJA 3HP9A 4DTOA 2VIXA 4DTSA 3QEVA 3QEXA 1XL3C 3OGKB 3SUOA 4J2EA 1MMOG 1XVDE 4EYWA 4KHWA 3LDBA 5IZ7A 2OVPB 4DU4A 2P1NB 2MW2A 1FZ4E 4EPHA 4FJ5A 2DTUA 3BVOA 4IT5A 3E4WA 1WAFA 3OGMB 3NAEA 3SJJA 4FK2A 3N1BA 3C6NB 4M42A 3TAGA 4FJ9A 4FJLA 2ATQA 2JHAA 4M45A 1LDKE 3SPZA 4RL5A 4FK4A 2K5SA 3SUNA 1WAJA 4KI4A 4M3TA 2E31A 3L1NA 2PFTA 3QESA 1XVGE 1FZ0E 4RNGA 3HGKE 2FW3A 2YB5A 3WSOA 3QERA 2OYQA 3MKSB 3QNOA 3L0MA 3L2OB 4EP9A 4J2BA 4KI6A 3TJYA 3RWUA 4M3ZA 4FJ7A 1XVCE 4ICGC 4M41A 1IG9A 4JRQA 3SUQA 3KD5E 2JH9A 2JHCA 1XMHE 2OZMA 4FJ8A 1N1CA 4AKIA 3CQ8A 3NDKA 3UIQA 4J2DA 4X5NA 3NE6A 4JS5A 3SCXA 3SPYA 2DEBA 1FZ9E 2P1OB 4FJIA 1FZHE 1JW2A 3QNNA 4FJHA 2OZSA 3NGIA 3RMDA 4GAMC 1XVBE 4HCBA 3S9HA 2RKHA 3TABA 4KHUA 4FVMA 3V7DB 1FZ1E 3L8BA 4M3XA 4DTNA 3NCIA 1XMGE 4M3UA 3TAEA 2P1QB 4E4BA 4KHYA 1IH7A 4DTRA 1FZ7E 2MZWB 4FK0A 4DU1A 4I6JB 2JQTA 4KHQA 4AKGA 3C94A 2H4TA 2B7MA 2P5OA 4QNCA 3OGLB 2MMBA 2OVQB 3SVIA 4JS4A 3K2OA 1FS1A 2P1MB 4B08A 4DTJA 3RMBA 3SUPA 3SNNA 2FYOA 4M3RA 1MTYG 3LZIA 3TL8B 4FJGA 1MHZG 2E32A 3SI6A 3HL8A 3NHGA 3SQ2A 4KHNA 2B1EA 3UO2A 4DTXA 3E4YA 4FJNA 4AI6A 3J27A 2QXFA 3CFRA 4FJKA 4M3WA 3SQ4A 3LD8A 5H37A 4DTUA 1NEXB 2P1PB 4I9LA 4ADOA 3KD1E 3CFOA 4J2AA 1FZIE 5IBKB 2PFVA 4QNDA 3J2PA 4JRPA 3SQ0A 4I9QA 1CLQA 4AKHA 3CFPA 2B8IA 3LZJA 3C95A 4DU3A 1XU3E 3QEPA 1FPOA 1FZ3E 2JPNA 4ADNA 1XVFE 3QEWA 2VJ4A 1FZ2E 1MHYG 1FZ8E 2LF6A 4FJMA 4KHSA 1Q9YA 2VJ5A
chains in the Genus database with same CATH topology
4M3YA 2LF3A 1FXXA 3QEIA 3LDSA 1XMFE 1FYZE 1FZ6E 2RCUA 1Q9XA 2JH8A 1FZ5E 4E3SA 1XU5E 3RMCA 2P5GA 4DTPA 3TAFA 3N1EA 3C6OB 4RG8A 4FJXA 2DY4A 3HGLA 4X5MA 3RMAA 2OVRB 3C6PB 3QETA 2HD0A 1P22A 3SQ1A 4HCCA 4DTMA 2JHPA 5IREA 1XVEE 4FJJA 3HP9A 4DTOA 2VIXA 4DTSA 3QEVA 3QEXA 1XL3C 3OGKB 3SUOA 4J2EA 1MMOG 1XVDE 4EYWA 4KHWA 3LDBA 5IZ7A 2OVPB 4DU4A 2P1NB 4EPHA 1FZ4E 4FJ5A 2DTUA 3NAEA 3E4WA 1WAFA 3OGMB 3SJJA 4FK2A 3N1BA 3C6NB 4M42A 3TAGA 4FJ9A 4FJLA 2ATQA 2JHAA 4M45A 1LDKE 3SPZA 4RL5A 4FK4A 3SUNA 1WAJA 4KI4A 4M3TA 2E31A 3L1NA 2PFTA 3QESA 1XVGE 1FZ0E 4RNGA 3HGKE 2FW3A 2YB5A 3WSOA 3QERA 2OYQA 3MKSB 3QNOA 3L0MA 3L2OB 4EP9A 4J2BA 4KI6A 3TJYA 3RWUA 4M3ZA 4FJ7A 1XVCE 4M41A 3KD5E 1IG9A 4JRQA 3SUQA 2JH9A 2JHCA 1XMHE 2OZMA 4FJ8A 4AKIA 3CQ8A 3NDKA 3UIQA 4J2DA 4X5NA 3NE6A 4JS5A 3SCXA 3SPYA 2DEBA 1FZ9E 2P1OB 4FJIA 1FZHE 3QNNA 4FJHA 2OZSA 3NGIA 3RMDA 4GAMC 1XVBE 4HCBA 3S9HA 3TABA 4KHUA 4FVMA 3V7DB 1FZ1E 3L8BA 4M3XA 4DTNA 3NCIA 1XMGE 4M3UA 3TAEA 2P1QB 4E4BA 4KHYA 1IH7A 4DTRA 1FZ7E 2MZWB 4FK0A 4DU1A 4I6JB 4KHQA 4AKGA 3C94A 2H4TA 2B7MA 2P5OA 4QNCA 3OGLB 2MMBA 2OVQB 3SVIA 4JS4A 3K2OA 1FS1A 2P1MB 4B08A 4DTJA 3RMBA 3SUPA 3SNNA 2FYOA 4M3RA 1MTYG 3LZIA 3TL8B 4FJGA 1MHZG 2E32A 3SI6A 3HL8A 3NHGA 3SQ2A 4KHNA 2B1EA 4DTXA 3E4YA 4FJNA 4AI6A 3J27A 2QXFA 3CFRA 4FJKA 4M3WA 3SQ4A 3LD8A 5H37A 4DTUA 1NEXB 2P1PB 4I9LA 4ADOA 3KD1E 3CFOA 4J2AA 1FZIE 5IBKB 2PFVA 4QNDA 3J2PA 4JRPA 3SQ0A 4I9QA 1CLQA 4AKHA 3CFPA 2B8IA 3LZJA 3C95A 4DU3A 1XU3E 3QEPA 1FZ3E 2JPNA 4ADNA 1XVFE 3QEWA 2VJ4A 1FZ2E 1MHYG 1FZ8E 2LF6A 4FJMA 4KHSA 1Q9YA 2VJ5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C6N B;  2P1O B;  2E32 A;  1LDK E;  2E31 A;  3C6O B;  1NEX B;  2P1P B;  3V7D B;  2OVR B;  3C6P B;  3WSO A;  1P22 A;  3MKS B;  5IBK B;  3L2O B;  2P1Q B;  3OGK B;  4I6J B;  3OGL B;  2OVQ B;  2OVP B;  2P1N B;  1FS1 A;  2P1M B;  3OGM B; 
#chains in the Genus database with same CATH topology
 4M3Y A;  2LF3 A;  1FXX A;  3QEI A;  3LDS A;  1XMF E;  1FYZ E;  1FZ6 E;  2RCU A;  3UO3 A;  1Q9X A;  2JH8 A;  1FZ5 E;  4E3S A;  1XU5 E;  3RMC A;  2P5G A;  4DTP A;  3TAF A;  3N1E A;  3C6O B;  4RG8 A;  4FJX A;  2DY4 A;  3HGL A;  4X5M A;  3RMA A;  2OVR B;  3C6P B;  3QET A;  2HD0 A;  1P22 A;  3SQ1 A;  4HCC A;  4DTM A;  2JHP A;  5IRE A;  1XVE E;  4FJJ A;  3HP9 A;  4DTO A;  2VIX A;  4DTS A;  3QEV A;  3QEX A;  1XL3 C;  3OGK B;  3SUO A;  4J2E A;  1MMO G;  1XVD E;  4EYW A;  4KHW A;  3LDB A;  5IZ7 A;  2OVP B;  4DU4 A;  2P1N B;  2MW2 A;  1FZ4 E;  4EPH A;  4FJ5 A;  2DTU A;  3BVO A;  4IT5 A;  3E4W A;  1WAF A;  3OGM B;  3NAE A;  3SJJ A;  4FK2 A;  3N1B A;  3C6N B;  4M42 A;  3TAG A;  4FJ9 A;  4FJL A;  2ATQ A;  2JHA A;  4M45 A;  1LDK E;  3SPZ A;  4RL5 A;  4FK4 A;  2K5S A;  3SUN A;  1WAJ A;  4KI4 A;  4M3T A;  2E31 A;  3L1N A;  2PFT A;  3QES A;  1XVG E;  1FZ0 E;  4RNG A;  3HGK E;  2FW3 A;  2YB5 A;  3WSO A;  3QER A;  2OYQ A;  3MKS B;  3QNO A;  3L0M A;  3L2O B;  4EP9 A;  4J2B A;  4KI6 A;  3TJY A;  3RWU A;  4M3Z A;  4FJ7 A;  1XVC E;  4ICG C;  4M41 A;  1IG9 A;  4JRQ A;  3SUQ A;  3KD5 E;  2JH9 A;  2JHC A;  1XMH E;  2OZM A;  4FJ8 A;  1N1C A;  4AKI A;  3CQ8 A;  3NDK A;  3UIQ A;  4J2D A;  4X5N A;  3NE6 A;  4JS5 A;  3SCX A;  3SPY A;  2DEB A;  1FZ9 E;  2P1O B;  4FJI A;  1FZH E;  1JW2 A;  3QNN A;  4FJH A;  2OZS A;  3NGI A;  3RMD A;  4GAM C;  1XVB E;  4HCB A;  3S9H A;  2RKH A;  3TAB A;  4KHU A;  4FVM A;  3V7D B;  1FZ1 E;  3L8B A;  4M3X A;  4DTN A;  3NCI A;  1XMG E;  4M3U A;  3TAE A;  2P1Q B;  4E4B A;  4KHY A;  1IH7 A;  4DTR A;  1FZ7 E;  2MZW B;  4FK0 A;  4DU1 A;  4I6J B;  2JQT A;  4KHQ A;  4AKG A;  3C94 A;  2H4T A;  2B7M A;  2P5O A;  4QNC A;  3OGL B;  2MMB A;  2OVQ B;  3SVI A;  4JS4 A;  3K2O A;  1FS1 A;  2P1M B;  4B08 A;  4DTJ A;  3RMB A;  3SUP A;  3SNN A;  2FYO A;  4M3R A;  1MTY G;  3LZI A;  3TL8 B;  4FJG A;  1MHZ G;  2E32 A;  3SI6 A;  3HL8 A;  3NHG A;  3SQ2 A;  4KHN A;  2B1E A;  3UO2 A;  4DTX A;  3E4Y A;  4FJN A;  4AI6 A;  3J27 A;  2QXF A;  3CFR A;  4FJK A;  4M3W A;  3SQ4 A;  3LD8 A;  5H37 A;  4DTU A;  1NEX B;  2P1P B;  4I9L A;  4ADO A;  3KD1 E;  3CFO A;  4J2A A;  1FZI E;  5IBK B;  2PFV A;  4QND A;  3J2P A;  4JRP A;  3SQ0 A;  4I9Q A;  1CLQ A;  4AKH A;  3CFP A;  2B8I A;  3LZJ A;  3C95 A;  4DU3 A;  1XU3 E;  3QEP A;  1FPO A;  1FZ3 E;  2JPN A;  4ADN A;  1XVF E;  3QEW A;  2VJ4 A;  1FZ2 E;  1MHY G;  1FZ8 E;  2LF6 A;  4FJM A;  4KHS A;  1Q9Y A;  2VJ5 A; 
#chains in the Genus database with same CATH homology
 4M3Y A;  2LF3 A;  1FXX A;  3QEI A;  3LDS A;  1XMF E;  1FYZ E;  1FZ6 E;  2RCU A;  1Q9X A;  2JH8 A;  1FZ5 E;  4E3S A;  1XU5 E;  3RMC A;  2P5G A;  4DTP A;  3TAF A;  3N1E A;  3C6O B;  4RG8 A;  4FJX A;  2DY4 A;  3HGL A;  4X5M A;  3RMA A;  2OVR B;  3C6P B;  3QET A;  2HD0 A;  1P22 A;  3SQ1 A;  4HCC A;  4DTM A;  2JHP A;  5IRE A;  1XVE E;  4FJJ A;  3HP9 A;  4DTO A;  2VIX A;  4DTS A;  3QEV A;  3QEX A;  1XL3 C;  3OGK B;  3SUO A;  4J2E A;  1MMO G;  1XVD E;  4EYW A;  4KHW A;  3LDB A;  5IZ7 A;  2OVP B;  4DU4 A;  2P1N B;  4EPH A;  1FZ4 E;  4FJ5 A;  2DTU A;  3NAE A;  3E4W A;  1WAF A;  3OGM B;  3SJJ A;  4FK2 A;  3N1B A;  3C6N B;  4M42 A;  3TAG A;  4FJ9 A;  4FJL A;  2ATQ A;  2JHA A;  4M45 A;  1LDK E;  3SPZ A;  4RL5 A;  4FK4 A;  3SUN A;  1WAJ A;  4KI4 A;  4M3T A;  2E31 A;  3L1N A;  2PFT A;  3QES A;  1XVG E;  1FZ0 E;  4RNG A;  3HGK E;  2FW3 A;  2YB5 A;  3WSO A;  3QER A;  2OYQ A;  3MKS B;  3QNO A;  3L0M A;  3L2O B;  4EP9 A;  4J2B A;  4KI6 A;  3TJY A;  3RWU A;  4M3Z A;  4FJ7 A;  1XVC E;  4M41 A;  3KD5 E;  1IG9 A;  4JRQ A;  3SUQ A;  2JH9 A;  2JHC A;  1XMH E;  2OZM A;  4FJ8 A;  4AKI A;  3CQ8 A;  3NDK A;  3UIQ A;  4J2D A;  4X5N A;  3NE6 A;  4JS5 A;  3SCX A;  3SPY A;  2DEB A;  1FZ9 E;  2P1O B;  4FJI A;  1FZH E;  3QNN A;  4FJH A;  2OZS A;  3NGI A;  3RMD A;  4GAM C;  1XVB E;  4HCB A;  3S9H A;  3TAB A;  4KHU A;  4FVM A;  3V7D B;  1FZ1 E;  3L8B A;  4M3X A;  4DTN A;  3NCI A;  1XMG E;  4M3U A;  3TAE A;  2P1Q B;  4E4B A;  4KHY A;  1IH7 A;  4DTR A;  1FZ7 E;  2MZW B;  4FK0 A;  4DU1 A;  4I6J B;  4KHQ A;  4AKG A;  3C94 A;  2H4T A;  2B7M A;  2P5O A;  4QNC A;  3OGL B;  2MMB A;  2OVQ B;  3SVI A;  4JS4 A;  3K2O A;  1FS1 A;  2P1M B;  4B08 A;  4DTJ A;  3RMB A;  3SUP A;  3SNN A;  2FYO A;  4M3R A;  1MTY G;  3LZI A;  3TL8 B;  4FJG A;  1MHZ G;  2E32 A;  3SI6 A;  3HL8 A;  3NHG A;  3SQ2 A;  4KHN A;  2B1E A;  4DTX A;  3E4Y A;  4FJN A;  4AI6 A;  3J27 A;  2QXF A;  3CFR A;  4FJK A;  4M3W A;  3SQ4 A;  3LD8 A;  5H37 A;  4DTU A;  1NEX B;  2P1P B;  4I9L A;  4ADO A;  3KD1 E;  3CFO A;  4J2A A;  1FZI E;  5IBK B;  2PFV A;  4QND A;  3J2P A;  4JRP A;  3SQ0 A;  4I9Q A;  1CLQ A;  4AKH A;  3CFP A;  2B8I A;  3LZJ A;  3C95 A;  4DU3 A;  1XU3 E;  3QEP A;  1FZ3 E;  2JPN A;  4ADN A;  1XVF E;  3QEW A;  2VJ4 A;  1FZ2 E;  1MHY G;  1FZ8 E;  2LF6 A;  4FJM A;  4KHS A;  1Q9Y A;  2VJ5 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...