2V8QA

Crystal structure of the regulatory fragment of mammalian ampk in complexes with amp
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
156
structure length
102
Chain Sequence
SMAWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEVAPRPGSHTIEFFEMCANLIKILAQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase
pubmed doi rcsb
molecule tags Transferase
source organism Rattus norvegicus
molecule keywords 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
total genus 23
structure length 102
sequence length 156
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2007-08-13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 2v8qA01
4EAIA 2QREA 4CFFA 2V92A 3TE5A 2Y8LA 2V9JA 2OOYA 2OOXA 1V5SA 2EHBD 4EAKA 4EAJA 3T4NA 2QRDA 4EAGA 1UL7A 2Y8QA 3OSEA 4EALA 3TDHA 2QLVA 2YA3A 2QR1A 2QRCA 2V8QA 2ZFDB
chains in the Genus database with same CATH superfamily
4EAIA 1PCZA 1UT4A 2FKMX 3ASMA 4CFFA 1K2YX 2LAEA 2Y8LA 4RODB 5JMVD 3I0XA 2I5WA 2OOYA 3H1ZA 3F0ZA 3OH6A 4EJYA 1LXTA 1NVPA 3OC3C 1UT7A 1QNAA 1N3AA 3CVSA 1YTBA 3D7QA 3NA5A 1YQLA 3OLPA 3ENCA 1TGHA 2NOLA 4TPSA 1KFIA 5EPCA 1QN5A 1N3CA 3RSMA 2H5AX 1B9KA 1Q9UA 1TBPA 2MZ8A 1YQRA 3TDHA 2NVMA 4PY5A 3CWTA 2QLVA 2VJ0A 1HU0A 4Q11A 5IYCP 1D3UA 1DIZA 2ZFDB 1QN9A 2JHJA 2NOZA 3HS9A 1QNBA 1QN6A 3UW2A 3CWAA 1JFIC 2V92A 5AN4A 3EIKA 4ROEB 2HKPA 3C04A 1QN4A 1TUOA 2OOXA 1R4XA 2EHBD 3OCIA 1KFQA 2JPIA 1NH2A 2FGTA 3CW7A 3F10A 2PWWA 1QN8A 2YH5A 3D4VA 3KTUA 3OGDA 2HZMA 2D0AA 1QTPA 3RPJA 2IV8A 1C9BB 4EJZA 4WXAA 3ULXA 2Z0FA 5BMNA 2O3OA 5JN5A 2XHIA 2NOHA 2QR1A 3ENOC 2QRCA 1KYUA 3BKQX 4WX8A 2V8QA 3DPTA 1M3HA 1EBMA 1AISA 3EAYA 1QNEA 2NOBA 1WQAA 2NOIA 1RM1A 4BJUA 4D7QA 2G30A 1EUVA 3SNSA 1KO9A 1WJWA 1PVSA 1V5SA 1VTLE 4ROCB 1MPGA 5F9CA 2NOFA 1E42A 5BMPA 2FUVA 1KY6A 1T6AA 4I8OA 1C47A 4EAKA 1QN3A 5IYDP 1VTOA 1PCJX 4EAJA 3PMGA 2D0BA 1C4GA 3T4NA 3OSMA 1M5Q1 1W80A 2QRDA 1P5GX 2Y8QA 3CWSA 3OH9A 3CWUA 1N39A 1LWWA 3DPUA 1LWYA 5IYBP 4DULA 1YQKA 1KYFA 1M3QA 4WZSD 2DKDA 3IH7A 2Z8UA 4C7PA 3OSTA 1XSZA 2JOIA 2QREA 2NWVA 4MRQA 3I0WA 3TE5A 4QG5A 5KL0A 2HL9A 2V9JA 3N89A 2R5XA 2NLVA 4B0AA 2H4LX 4D7RA 1KYDA 1J3MA 1KY7A 3HS8A 3I3WA 1PZDA 3VN5A 1LWVA 2JHNA 1NGMA 1QN7A 1PCMX 1VOKA 3KRMA 1CDWA 1QNCA 2DKCA 2HL8A 3CVTA 1K35A 4EAGA 2NOEA 1UL7A 2D0CA 3OSEA 4IL8A 4EALA 2IV9A 1YTFA 1JDYA 2F7LA 2MJ7A 1YQMA 1P5DX 1FN7A 1VKLA 2HZSA 2YA3A 4HJHA 1TBAB 3PDKA 1QTSA 2DKAA 1MP9A 2FKFA 5HSHA 1VOLB
chains in the Genus database with same CATH topology
4EAIA 2QREA 4CFFA 2V92A 3TE5A 2Y8LA 2V9JA 2OOYA 2OOXA 1V5SA 2EHBD 4EAKA 4EAJA 3T4NA 2QRDA 4EAGA 1UL7A 2Y8QA 3OSEA 4EALA 3TDHA 2QLVA 2YA3A 2QR1A 2QRCA 2V8QA 2ZFDB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EAI A;  2QRE A;  4CFF A;  2V92 A;  3TE5 A;  2Y8L A;  2V9J A;  2OOY A;  2OOX A;  1V5S A;  2EHB D;  4EAK A;  4EAJ A;  3T4N A;  2QRD A;  4EAG A;  1UL7 A;  2Y8Q A;  3OSE A;  4EAL A;  3TDH A;  2QLV A;  2YA3 A;  2QR1 A;  2QRC A;  2V8Q A;  2ZFD B; 
#chains in the Genus database with same CATH topology
 4EAI A;  1PCZ A;  1UT4 A;  2FKM X;  3ASM A;  4CFF A;  1K2Y X;  2LAE A;  2Y8L A;  4ROD B;  5JMV D;  3I0X A;  2I5W A;  2OOY A;  3H1Z A;  3F0Z A;  3OH6 A;  4EJY A;  1LXT A;  1NVP A;  3OC3 C;  1UT7 A;  1QNA A;  1N3A A;  3CVS A;  1YTB A;  3D7Q A;  3NA5 A;  1YQL A;  3OLP A;  3ENC A;  1TGH A;  2NOL A;  4TPS A;  1KFI A;  5EPC A;  1QN5 A;  1N3C A;  3RSM A;  2H5A X;  1B9K A;  1Q9U A;  1TBP A;  2MZ8 A;  1YQR A;  3TDH A;  2NVM A;  4PY5 A;  3CWT A;  2QLV A;  2VJ0 A;  1HU0 A;  4Q11 A;  5IYC P;  1D3U A;  1DIZ A;  2ZFD B;  1QN9 A;  2JHJ A;  2NOZ A;  3HS9 A;  1QNB A;  1QN6 A;  3UW2 A;  3CWA A;  1JFI C;  2V92 A;  5AN4 A;  3EIK A;  4ROE B;  2HKP A;  3C04 A;  1QN4 A;  1TUO A;  2OOX A;  1R4X A;  2EHB D;  3OCI A;  1KFQ A;  2JPI A;  1NH2 A;  2FGT A;  3CW7 A;  3F10 A;  2PWW A;  1QN8 A;  2YH5 A;  3D4V A;  3KTU A;  3OGD A;  2HZM A;  2D0A A;  1QTP A;  3RPJ A;  2IV8 A;  1C9B B;  4EJZ A;  4WXA A;  3ULX A;  2Z0F A;  5BMN A;  2O3O A;  5JN5 A;  2XHI A;  2NOH A;  2QR1 A;  3ENO C;  2QRC A;  1KYU A;  3BKQ X;  4WX8 A;  2V8Q A;  3DPT A;  1M3H A;  1EBM A;  1AIS A;  3EAY A;  1QNE A;  2NOB A;  1WQA A;  2NOI A;  1RM1 A;  4BJU A;  4D7Q A;  2G30 A;  1EUV A;  3SNS A;  1KO9 A;  1WJW A;  1PVS A;  1V5S A;  1VTL E;  4ROC B;  1MPG A;  5F9C A;  2NOF A;  1E42 A;  5BMP A;  2FUV A;  1KY6 A;  1T6A A;  4I8O A;  1C47 A;  4EAK A;  1QN3 A;  5IYD P;  1VTO A;  1PCJ X;  4EAJ A;  3PMG A;  2D0B A;  1C4G A;  3T4N A;  3OSM A;  1M5Q 1;  1W80 A;  2QRD A;  1P5G X;  2Y8Q A;  3CWS A;  3OH9 A;  3CWU A;  1N39 A;  1LWW A;  3DPU A;  1LWY A;  5IYB P;  4DUL A;  1YQK A;  1KYF A;  1M3Q A;  4WZS D;  2DKD A;  3IH7 A;  2Z8U A;  4C7P A;  3OST A;  1XSZ A;  2JOI A;  2QRE A;  2NWV A;  4MRQ A;  3I0W A;  3TE5 A;  4QG5 A;  5KL0 A;  2HL9 A;  2V9J A;  3N89 A;  2R5X A;  2NLV A;  4B0A A;  2H4L X;  4D7R A;  1KYD A;  1J3M A;  1KY7 A;  3HS8 A;  3I3W A;  1PZD A;  3VN5 A;  1LWV A;  2JHN A;  1NGM A;  1QN7 A;  1PCM X;  1VOK A;  3KRM A;  1CDW A;  1QNC A;  2DKC A;  2HL8 A;  3CVT A;  1K35 A;  4EAG A;  2NOE A;  1UL7 A;  2D0C A;  3OSE A;  4IL8 A;  4EAL A;  2IV9 A;  1YTF A;  1JDY A;  2F7L A;  2MJ7 A;  1YQM A;  1P5D X;  1FN7 A;  1VKL A;  2HZS A;  2YA3 A;  4HJH A;  1TBA B;  3PDK A;  1QTS A;  2DKA A;  1MP9 A;  2FKF A;  5HSH A;  1VOL B; 
#chains in the Genus database with same CATH homology
 4EAI A;  2QRE A;  4CFF A;  2V92 A;  3TE5 A;  2Y8L A;  2V9J A;  2OOY A;  2OOX A;  1V5S A;  2EHB D;  4EAK A;  4EAJ A;  3T4N A;  2QRD A;  4EAG A;  1UL7 A;  2Y8Q A;  3OSE A;  4EAL A;  3TDH A;  2QLV A;  2YA3 A;  2QR1 A;  2QRC A;  2V8Q A;  2ZFD B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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