5JN5A

Crystal structure of the d263y missense variant of human pgm1
Total Genus 187
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
187
sequence length
563
structure length
558
Chain Sequence
NMVKIVTVKTQAYQDQKPGTSGLRKRVKVFQSSANYAENFIQSIISTVEPAQRQEATLVVGGDGRFYMKEAIQLIARIAAANGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTAHNPGGPNGDFGIKFNISNGGPAPEAITDKIFQISKTIEEYAVCPDLKVDLGVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRSIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEDFGGHHPYPNLTYAADLVETMKSGEHDFGAAFDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMPTSGALDRVASATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGGATIRLYIDSYEKDVAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Phosphoglucomutase-1
publication title Asp263 missense variants perturb the active site of human phosphoglucomutase 1.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Isomerase
total genus 187
structure length 558
sequence length 563
chains with identical sequence B
ec nomenclature ec 5.4.2.2: Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
pdb deposition date 2016-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00408 PGM_PMM_IV Phosphoglucomutase/phosphomannomutase, C-terminal domain
A PF02878 PGM_PMM_I Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
A PF02879 PGM_PMM_II Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
A PF02880 PGM_PMM_III Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.50 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Alpha-D-phosphohexomutase, C-terminal domain 5jn5A04
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5jn5A02
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5jn5A03
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5jn5A01
5KL0A 1JDYA 2DKCA 1WQAA 1LXTA 5JMVD 1PCMX 4WXAA 1P5DX 4WX8A 3NA5A 2H4LX 1C4GA 3PDKA 2DKAA 2DKDA 2Z0FA 3OLPA 5HSHA 2FUVA 2JPIA 2FKMX 2H5AX 3PMGA 4IL8A 1K2YX 3I3WA 2EIUA 3C04A 1C47A 1PCJX 4QG5A 5BMNA 3ENCA 5F9CA 1P5GX 3RSMA 4MRQA 3ENOC 1KFIA 4BJUA 2FKFA 4HJHA 5BMPA 1WJWA 2EHPA 1KFQA 3UW2A 3BKQX 5JN5A 2F7LA 5EPCA 1K35A 1TUOA 1VKLA
chains in the Genus database with same CATH superfamily
2HL8A 2FGTA 3OSMA 1QN7A 1WQAA 1LXTA 1MP9A 2QR1A 2V9JA 2V8QA 4WXAA 3H1ZA 3VN5A 1PZDA 2H4LX 3PDKA 1YQKA 2IV9A 1TGHA 1J3MA 2MZ8A 2I5WA 3HS9A 2JHNA 1VOKA 1D3UA 3T4NA 4WZSD 4EAKA 1EUVA 2H5AX 1TBPA 3ULXA 4PY5A 2Y8LA 4B0AA 2D0CA 2QLVA 1E42A 3KTUA 2NVMA 2NOFA 1QN9A 1M5Q1 3ENCA 2NLVA 2EHBD 2QRCA 2R5XA 1QNEA 1M3QA 3F0ZA 4CFFA 1KO9A 5EPCA 1VOLB 4EAGA 2NOZA 5KL0A 2DKCA 2HZMA 3DPTA 5JMVD 1QN5A 2OOXA 1P5DX 2NOBA 4EALA 3OC3C 4RODB 2DKAA 2DKDA 5IYCP 2QREA 3OSEA 2Z0FA 1NGMA 1QN8A 4D7RA 3ASMA 2Y8QA 1LWYA 3CWSA 1PCZA 3PMGA 4IL8A 4DULA 2NOEA 2NOLA 3SNSA 1K2YX 1KYDA 3N89A 3EAYA 1VTLE 3C04A 1NH2A 1PCJX 1UT4A 4BJUA 1W80A 2FKFA 3OSTA 1KFQA 3UW2A 3BKQX 3TDHA 2F7LA 4EAJA 1XSZA 2JOIA 2D0AA 4I8OA 1CDWA 2YH5A 1N39A 1JDYA 1QNAA 1QN3A 3CWAA 1PCMX 1DIZA 1NVPA 1KYUA 4ROCB 1JFIC 1FN7A 2YA3A 1EBMA 1R4XA 1RM1A 1YTBA 2NOHA 3RPJA 3TE5A 4EAIA 3OLPA 4EJYA 1TBAB 2JPIA 1QTSA 4TPSA 3OH9A 2HKPA 3EIKA 4ROEB 2QRDA 1YQMA 1QN6A 1KYFA 3I3WA 3F10A 5IYDP 2OOYA 4D7QA 2ZFDB 4QG5A 2NWVA 3OCIA 5BMNA 3CW7A 1YQLA 1KY6A 1P5GX 3RSMA 1N3CA 3ENOC 1T6AA 2EHPA 5AN4A 1N3AA 1M3HA 1LWWA 2IV8A 1TUOA 1C4GA 3D7QA 1VKLA 3OGDA 3I0WA 3CVSA 3CWTA 4EJZA 3D4VA 2HZSA 3CVTA 3HS8A 2V92A 3NA5A 4WX8A 2NOIA 1MPGA 2XHIA 3CWUA 1V5SA 1C9BB 2HL9A 2Z8UA 1PVSA 5HSHA 2FUVA 3I0XA 3OH6A 4C7PA 2FKMX 1QNCA 1YQRA 1AISA 2LAEA 1UL7A 1UT7A 2EIUA 2JHJA 1C47A 2D0BA 1HU0A 5IYBP 1KY7A 1Q9UA 5F9CA 4Q11A 4MRQA 1KFIA 1QN4A 4HJHA 1QTPA 1WJWA 5BMPA 1VTOA 2O3OA 2VJ0A 2G30A 1QNBA 2MJ7A 3IH7A 1LWVA 1YTFA 3DPUA 1B9KA 1K35A 2PWWA 5JN5A 3KRMA
chains in the Genus database with same CATH topology
5KL0A 1JDYA 2DKCA 1WQAA 1LXTA 5JMVD 1PCMX 4WXAA 1P5DX 4WX8A 3NA5A 2H4LX 1C4GA 3PDKA 2DKAA 2DKDA 2Z0FA 3OLPA 5HSHA 2FUVA 2JPIA 2FKMX 2H5AX 3PMGA 4IL8A 1K2YX 3I3WA 2EIUA 3C04A 1C47A 1PCJX 4QG5A 5BMNA 3ENCA 5F9CA 1P5GX 3RSMA 4MRQA 3ENOC 1KFIA 4BJUA 2FKFA 4HJHA 5BMPA 1WJWA 2EHPA 1KFQA 3UW2A 3BKQX 5JN5A 2F7LA 5EPCA 1K35A 1TUOA 1VKLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5KL0 A;  1JDY A;  2DKC A;  1WQA A;  1LXT A;  5JMV D;  1PCM X;  4WXA A;  1P5D X;  4WX8 A;  3NA5 A;  2H4L X;  1C4G A;  3PDK A;  2DKA A;  2DKD A;  2Z0F A;  3OLP A;  5HSH A;  2FUV A;  2JPI A;  2FKM X;  2H5A X;  3PMG A;  4IL8 A;  1K2Y X;  3I3W A;  2EIU A;  3C04 A;  1C47 A;  1PCJ X;  4QG5 A;  5BMN A;  3ENC A;  5F9C A;  1P5G X;  3RSM A;  4MRQ A;  3ENO C;  1KFI A;  4BJU A;  2FKF A;  4HJH A;  5BMP A;  1WJW A;  2EHP A;  1KFQ A;  3UW2 A;  3BKQ X;  5JN5 A;  2F7L A;  5EPC A;  1K35 A;  1TUO A;  1VKL A; 
#chains in the Genus database with same CATH topology
 2HL8 A;  2FGT A;  3OSM A;  1QN7 A;  1WQA A;  1LXT A;  1MP9 A;  2QR1 A;  2V9J A;  2V8Q A;  4WXA A;  3H1Z A;  3VN5 A;  1PZD A;  2H4L X;  3PDK A;  1YQK A;  2IV9 A;  1TGH A;  1J3M A;  2MZ8 A;  2I5W A;  3HS9 A;  2JHN A;  1VOK A;  1D3U A;  3T4N A;  4WZS D;  4EAK A;  1EUV A;  2H5A X;  1TBP A;  3ULX A;  4PY5 A;  2Y8L A;  4B0A A;  2D0C A;  2QLV A;  1E42 A;  3KTU A;  2NVM A;  2NOF A;  1QN9 A;  1M5Q 1;  3ENC A;  2NLV A;  2EHB D;  2QRC A;  2R5X A;  1QNE A;  1M3Q A;  3F0Z A;  4CFF A;  1KO9 A;  5EPC A;  1VOL B;  4EAG A;  2NOZ A;  5KL0 A;  2DKC A;  2HZM A;  3DPT A;  5JMV D;  1QN5 A;  2OOX A;  1P5D X;  2NOB A;  4EAL A;  3OC3 C;  4ROD B;  2DKA A;  2DKD A;  5IYC P;  2QRE A;  3OSE A;  2Z0F A;  1NGM A;  1QN8 A;  4D7R A;  3ASM A;  2Y8Q A;  1LWY A;  3CWS A;  1PCZ A;  3PMG A;  4IL8 A;  4DUL A;  2NOE A;  2NOL A;  3SNS A;  1K2Y X;  1KYD A;  3N89 A;  3EAY A;  1VTL E;  3C04 A;  1NH2 A;  1PCJ X;  1UT4 A;  4BJU A;  1W80 A;  2FKF A;  3OST A;  1KFQ A;  3UW2 A;  3BKQ X;  3TDH A;  2F7L A;  4EAJ A;  1XSZ A;  2JOI A;  2D0A A;  4I8O A;  1CDW A;  2YH5 A;  1N39 A;  1JDY A;  1QNA A;  1QN3 A;  3CWA A;  1PCM X;  1DIZ A;  1NVP A;  1KYU A;  4ROC B;  1JFI C;  1FN7 A;  2YA3 A;  1EBM A;  1R4X A;  1RM1 A;  1YTB A;  2NOH A;  3RPJ A;  3TE5 A;  4EAI A;  3OLP A;  4EJY A;  1TBA B;  2JPI A;  1QTS A;  4TPS A;  3OH9 A;  2HKP A;  3EIK A;  4ROE B;  2QRD A;  1YQM A;  1QN6 A;  1KYF A;  3I3W A;  3F10 A;  5IYD P;  2OOY A;  4D7Q A;  2ZFD B;  4QG5 A;  2NWV A;  3OCI A;  5BMN A;  3CW7 A;  1YQL A;  1KY6 A;  1P5G X;  3RSM A;  1N3C A;  3ENO C;  1T6A A;  2EHP A;  5AN4 A;  1N3A A;  1M3H A;  1LWW A;  2IV8 A;  1TUO A;  1C4G A;  3D7Q A;  1VKL A;  3OGD A;  3I0W A;  3CVS A;  3CWT A;  4EJZ A;  3D4V A;  2HZS A;  3CVT A;  3HS8 A;  2V92 A;  3NA5 A;  4WX8 A;  2NOI A;  1MPG A;  2XHI A;  3CWU A;  1V5S A;  1C9B B;  2HL9 A;  2Z8U A;  1PVS A;  5HSH A;  2FUV A;  3I0X A;  3OH6 A;  4C7P A;  2FKM X;  1QNC A;  1YQR A;  1AIS A;  2LAE A;  1UL7 A;  1UT7 A;  2EIU A;  2JHJ A;  1C47 A;  2D0B A;  1HU0 A;  5IYB P;  1KY7 A;  1Q9U A;  5F9C A;  4Q11 A;  4MRQ A;  1KFI A;  1QN4 A;  4HJH A;  1QTP A;  1WJW A;  5BMP A;  1VTO A;  2O3O A;  2VJ0 A;  2G30 A;  1QNB A;  2MJ7 A;  3IH7 A;  1LWV A;  1YTF A;  3DPU A;  1B9K A;  1K35 A;  2PWW A;  5JN5 A;  3KRM A; 
#chains in the Genus database with same CATH homology
 5KL0 A;  1JDY A;  2DKC A;  1WQA A;  1LXT A;  5JMV D;  1PCM X;  4WXA A;  1P5D X;  4WX8 A;  3NA5 A;  2H4L X;  1C4G A;  3PDK A;  2DKA A;  2DKD A;  2Z0F A;  3OLP A;  5HSH A;  2FUV A;  2JPI A;  2FKM X;  2H5A X;  3PMG A;  4IL8 A;  1K2Y X;  3I3W A;  2EIU A;  3C04 A;  1C47 A;  1PCJ X;  4QG5 A;  5BMN A;  3ENC A;  5F9C A;  1P5G X;  3RSM A;  4MRQ A;  3ENO C;  1KFI A;  4BJU A;  2FKF A;  4HJH A;  5BMP A;  1WJW A;  2EHP A;  1KFQ A;  3UW2 A;  3BKQ X;  5JN5 A;  2F7L A;  5EPC A;  1K35 A;  1TUO A;  1VKL A; 
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similar chains in the pdb database (?% sequence similarity)

 
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