5JN5A

Crystal structure of the d263y missense variant of human pgm1
Total Genus 187
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
187
sequence length
563
structure length
558
Chain Sequence
NMVKIVTVKTQAYQDQKPGTSGLRKRVKVFQSSANYAENFIQSIISTVEPAQRQEATLVVGGDGRFYMKEAIQLIARIAAANGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTAHNPGGPNGDFGIKFNISNGGPAPEAITDKIFQISKTIEEYAVCPDLKVDLGVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRSIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEDFGGHHPYPNLTYAADLVETMKSGEHDFGAAFDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMPTSGALDRVASATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGGATIRLYIDSYEKDVAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Isomerase
molecule keywords Phosphoglucomutase-1
publication title Asp263 missense variants perturb the active site of human phosphoglucomutase 1.
pubmed doi rcsb
source organism Homo sapiens
total genus 187
structure length 558
sequence length 563
chains with identical sequence B
ec nomenclature ec 5.4.2.2: Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
pdb deposition date 2016-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00408 PGM_PMM_IV Phosphoglucomutase/phosphomannomutase, C-terminal domain
A PF02878 PGM_PMM_I Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
A PF02879 PGM_PMM_II Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
A PF02880 PGM_PMM_III Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.50 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Alpha-D-phosphohexomutase, C-terminal domain 5jn5A04
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5jn5A02
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5jn5A03
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5jn5A01
2EIUA 4BJUA 2DKDA 2FKFA 2H5AX 1LXTA 2JPIA 5EPCA 1KFIA 3ENCA 4WXAA 4HJHA 1PCJX 5HSHA 1C47A 1P5GX 1K2YX 3OLPA 5JMVD 3BKQX 5JN5A 4QG5A 5KL0A 1WQAA 5BMNA 2FKMX 1PCMX 1C4GA 1WJWA 4WX8A 3I3WA 1TUOA 1K35A 1JDYA 2EHPA 4IL8A 2DKAA 1P5DX 3PMGA 3ENOC 1KFQA 4MRQA 3NA5A 1VKLA 3C04A 2F7LA 5F9CA 2DKCA 2H4LX 3RSMA 5BMPA 2FUVA 3UW2A 3PDKA 2Z0FA
chains in the Genus database with same CATH superfamily
4B0AA 2Z8UA 1CDWA 2FKFA 1QTPA 1RM1A 2QR1A 2NOFA 4WXAA 1PCJX 2MZ8A 1QNCA 1P5GX 1NGMA 3BKQX 5JN5A 5KL0A 2FKMX 1C4GA 1VOLB 1Q9UA 4TPSA 2QRCA 4EAKA 2D0AA 1YTBA 3ASMA 3F0ZA 1JFIC 1JDYA 3CVSA 1YQRA 5IYCP 2I5WA 4EJYA 3OCIA 2DKAA 1P5DX 1PCZA 1M3QA 2R5XA 3OC3C 1VTOA 1KO9A 3ULXA 4EAIA 1C9BB 2NOIA 1B9KA 3NA5A 5F9CA 4DULA 5BMPA 1QN5A 3IH7A 2IV8A 3TDHA 1QTSA 3PDKA 2EIUA 2JHJA 2H5AX 1LXTA 2JPIA 1TBAB 2QLVA 1KFIA 2NWVA 4HJHA 4EALA 2YH5A 3HS9A 1C47A 1QN9A 1K2YX 1PZDA 3OSMA 1UT4A 2V9JA 1EBMA 1QN4A 1D3UA 3DPTA 1DIZA 2IV9A 3EIKA 1KYDA 4WX8A 3T4NA 1UL7A 1FN7A 2NOBA 1K35A 1VOKA 2LAEA 2Y8LA 4PY5A 1XSZA 3PMGA 1QN7A 3RPJA 3ENOC 1LWYA 4MRQA 2H4LX 2FUVA 2HL8A 3HS8A 1YTFA 2ZFDB 1QNEA 1W80A 2Z0FA 1KYFA 2MJ7A 2DKDA 2O3OA 5EPCA 1MP9A 3D7QA 3F10A 1VTLE 3CWSA 2Y8QA 3ENCA 1UT7A 1YQLA 1HU0A 1MPGA 5HSHA 1M3HA 1QNAA 4WZSD 2JHNA 1EUVA 5JMVD 4EJZA 4QG5A 1NVPA 1QN6A 3EAYA 3OSTA 2VJ0A 3I0XA 1PCMX 1J3MA 1LWVA 1YQKA 3I3WA 1N3CA 1LWWA 1KY7A 1TUOA 3OSEA 1QN8A 1AISA 1PVSA 2NOHA 4EAJA 2EHPA 4IL8A 2OOYA 2FGTA 3KTUA 1TGHA 2NLVA 3H1ZA 1KFQA 2HZSA 1N3AA 1QN3A 4ROCB 3CVTA 2G30A 3C04A 4D7QA 2F7LA 2NOEA 2DKCA 1YQMA 3OGDA 2JOIA 1T6AA 2HL9A 4BJUA 3CW7A 2XHIA 4Q11A 4RODB 2QREA 1E42A 5AN4A 3OH9A 1NH2A 5IYDP 1R4XA 3OLPA 3VN5A 1KYUA 3SNSA 3CWUA 2EHBD 1WQAA 5BMNA 3CWAA 3DPUA 2OOXA 2QRDA 2V92A 2NOZA 1WJWA 4CFFA 4EAGA 1M5Q1 2D0BA 1QNBA 4D7RA 3TE5A 4I8OA 3N89A 4ROEB 1V5SA 2D0CA 2HKPA 2PWWA 5IYBP 3OH6A 3D4VA 3CWTA 1TBPA 1VKLA 1KY6A 2NVMA 3RSMA 2NOLA 2V8QA 3I0WA 3KRMA 3UW2A 2HZMA 2YA3A 1N39A 4C7PA
chains in the Genus database with same CATH topology
2EIUA 4BJUA 2DKDA 2FKFA 2H5AX 1LXTA 2JPIA 5EPCA 1KFIA 3ENCA 4WXAA 4HJHA 1PCJX 5HSHA 1C47A 1P5GX 1K2YX 3OLPA 5JMVD 3BKQX 5JN5A 4QG5A 5KL0A 1WQAA 5BMNA 2FKMX 1PCMX 1C4GA 1WJWA 4WX8A 3I3WA 1TUOA 1K35A 1JDYA 2EHPA 4IL8A 2DKAA 1P5DX 3PMGA 3ENOC 1KFQA 4MRQA 3NA5A 1VKLA 3C04A 2F7LA 5F9CA 2DKCA 2H4LX 3RSMA 5BMPA 2FUVA 3UW2A 3PDKA 2Z0FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EIU A;  4BJU A;  2DKD A;  2FKF A;  2H5A X;  1LXT A;  2JPI A;  5EPC A;  1KFI A;  3ENC A;  4WXA A;  4HJH A;  1PCJ X;  5HSH A;  1C47 A;  1P5G X;  1K2Y X;  3OLP A;  5JMV D;  3BKQ X;  5JN5 A;  4QG5 A;  5KL0 A;  1WQA A;  5BMN A;  2FKM X;  1PCM X;  1C4G A;  1WJW A;  4WX8 A;  3I3W A;  1TUO A;  1K35 A;  1JDY A;  2EHP A;  4IL8 A;  2DKA A;  1P5D X;  3PMG A;  3ENO C;  1KFQ A;  4MRQ A;  3NA5 A;  1VKL A;  3C04 A;  2F7L A;  5F9C A;  2DKC A;  2H4L X;  3RSM A;  5BMP A;  2FUV A;  3UW2 A;  3PDK A;  2Z0F A; 
#chains in the Genus database with same CATH topology
 4B0A A;  2Z8U A;  1CDW A;  2FKF A;  1QTP A;  1RM1 A;  2QR1 A;  2NOF A;  4WXA A;  1PCJ X;  2MZ8 A;  1QNC A;  1P5G X;  1NGM A;  3BKQ X;  5JN5 A;  5KL0 A;  2FKM X;  1C4G A;  1VOL B;  1Q9U A;  4TPS A;  2QRC A;  4EAK A;  2D0A A;  1YTB A;  3ASM A;  3F0Z A;  1JFI C;  1JDY A;  3CVS A;  1YQR A;  5IYC P;  2I5W A;  4EJY A;  3OCI A;  2DKA A;  1P5D X;  1PCZ A;  1M3Q A;  2R5X A;  3OC3 C;  1VTO A;  1KO9 A;  3ULX A;  4EAI A;  1C9B B;  2NOI A;  1B9K A;  3NA5 A;  5F9C A;  4DUL A;  5BMP A;  1QN5 A;  3IH7 A;  2IV8 A;  3TDH A;  1QTS A;  3PDK A;  2EIU A;  2JHJ A;  2H5A X;  1LXT A;  2JPI A;  1TBA B;  2QLV A;  1KFI A;  2NWV A;  4HJH A;  4EAL A;  2YH5 A;  3HS9 A;  1C47 A;  1QN9 A;  1K2Y X;  1PZD A;  3OSM A;  1UT4 A;  2V9J A;  1EBM A;  1QN4 A;  1D3U A;  3DPT A;  1DIZ A;  2IV9 A;  3EIK A;  1KYD A;  4WX8 A;  3T4N A;  1UL7 A;  1FN7 A;  2NOB A;  1K35 A;  1VOK A;  2LAE A;  2Y8L A;  4PY5 A;  1XSZ A;  3PMG A;  1QN7 A;  3RPJ A;  3ENO C;  1LWY A;  4MRQ A;  2H4L X;  2FUV A;  2HL8 A;  3HS8 A;  1YTF A;  2ZFD B;  1QNE A;  1W80 A;  2Z0F A;  1KYF A;  2MJ7 A;  2DKD A;  2O3O A;  5EPC A;  1MP9 A;  3D7Q A;  3F10 A;  1VTL E;  3CWS A;  2Y8Q A;  3ENC A;  1UT7 A;  1YQL A;  1HU0 A;  1MPG A;  5HSH A;  1M3H A;  1QNA A;  4WZS D;  2JHN A;  1EUV A;  5JMV D;  4EJZ A;  4QG5 A;  1NVP A;  1QN6 A;  3EAY A;  3OST A;  2VJ0 A;  3I0X A;  1PCM X;  1J3M A;  1LWV A;  1YQK A;  3I3W A;  1N3C A;  1LWW A;  1KY7 A;  1TUO A;  3OSE A;  1QN8 A;  1AIS A;  1PVS A;  2NOH A;  4EAJ A;  2EHP A;  4IL8 A;  2OOY A;  2FGT A;  3KTU A;  1TGH A;  2NLV A;  3H1Z A;  1KFQ A;  2HZS A;  1N3A A;  1QN3 A;  4ROC B;  3CVT A;  2G30 A;  3C04 A;  4D7Q A;  2F7L A;  2NOE A;  2DKC A;  1YQM A;  3OGD A;  2JOI A;  1T6A A;  2HL9 A;  4BJU A;  3CW7 A;  2XHI A;  4Q11 A;  4ROD B;  2QRE A;  1E42 A;  5AN4 A;  3OH9 A;  1NH2 A;  5IYD P;  1R4X A;  3OLP A;  3VN5 A;  1KYU A;  3SNS A;  3CWU A;  2EHB D;  1WQA A;  5BMN A;  3CWA A;  3DPU A;  2OOX A;  2QRD A;  2V92 A;  2NOZ A;  1WJW A;  4CFF A;  4EAG A;  1M5Q 1;  2D0B A;  1QNB A;  4D7R A;  3TE5 A;  4I8O A;  3N89 A;  4ROE B;  1V5S A;  2D0C A;  2HKP A;  2PWW A;  5IYB P;  3OH6 A;  3D4V A;  3CWT A;  1TBP A;  1VKL A;  1KY6 A;  2NVM A;  3RSM A;  2NOL A;  2V8Q A;  3I0W A;  3KRM A;  3UW2 A;  2HZM A;  2YA3 A;  1N39 A;  4C7P A; 
#chains in the Genus database with same CATH homology
 2EIU A;  4BJU A;  2DKD A;  2FKF A;  2H5A X;  1LXT A;  2JPI A;  5EPC A;  1KFI A;  3ENC A;  4WXA A;  4HJH A;  1PCJ X;  5HSH A;  1C47 A;  1P5G X;  1K2Y X;  3OLP A;  5JMV D;  3BKQ X;  5JN5 A;  4QG5 A;  5KL0 A;  1WQA A;  5BMN A;  2FKM X;  1PCM X;  1C4G A;  1WJW A;  4WX8 A;  3I3W A;  1TUO A;  1K35 A;  1JDY A;  2EHP A;  4IL8 A;  2DKA A;  1P5D X;  3PMG A;  3ENO C;  1KFQ A;  4MRQ A;  3NA5 A;  1VKL A;  3C04 A;  2F7L A;  5F9C A;  2DKC A;  2H4L X;  3RSM A;  5BMP A;  2FUV A;  3UW2 A;  3PDK A;  2Z0F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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