4EALA

Co-crystal of ampk core with atp soaked with amp
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
99
structure length
92
Chain Sequence
WHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDGSHTIEFFEMCANLIKILAQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
pubmed doi rcsb
molecule keywords 5'-AMP-activated protein kinase catalytic subunit alpha-1
molecule tags Transferase
source organism Rattus norvegicus
total genus 21
structure length 92
sequence length 99
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 4ealA01
3TE5A 2Y8LA 2QLVA 4EAGA 3T4NA 4EAIA 3TDHA 2YA3A 3OSEA 2EHBD 2OOYA 2V9JA 2QRDA 2ZFDB 2Y8QA 2QREA 2V92A 2QR1A 2V8QA 2QRCA 4EAJA 4EALA 4EAKA 1V5SA 1UL7A 4CFFA 2OOXA
chains in the Genus database with same CATH superfamily
3CW7A 3OH6A 1TUOA 2Y8LA 3ASMA 1KFQA 2XHIA 1KO9A 2JOIA 5EPCA 1PCMX 1XSZA 3OLPA 3T4NA 3CWSA 4EJZA 3TDHA 3ENOC 3EIKA 1VTLE 1QNBA 3HS9A 3I3WA 1FN7A 2HL8A 1K35A 2FGTA 2LAEA 2V9JA 2QRDA 1VOKA 2JHNA 2Y8QA 1C47A 2V92A 4D7QA 1P5GX 1CDWA 2MJ7A 4TPSA 1DIZA 4EAJA 1Q9UA 1V5SA 1EUVA 1YQKA 2JPIA 2HKPA 4CFFA 2OOXA 1QN7A 3OC3C 1QN6A 5JN5A 4I8OA 2YH5A 1LWVA 2JHJA 3TE5A 2NWVA 1YQRA 3OCIA 4IL8A 1YQMA 4EJYA 5IYDP 3F0ZA 4EAGA 3DPTA 3KRMA 2G30A 3OGDA 1YTBA 4MRQA 4EAIA 2NOFA 1NGMA 1JFIC 3OSMA 1LWWA 1QN9A 1PVSA 3PMGA 1KYFA 2DKDA 3BKQX 2Z0FA 4ROCB 3EAYA 2O3OA 1NH2A 3F10A 2F7LA 3RPJA 4C7PA 2NOZA 2HL9A 1WJWA 3OH9A 1C4GA 1N39A 2R5XA 3N89A 2FKFA 1P5DX 3OSTA 4DULA 5IYCP 1M3QA 1QN3A 1UT7A 3D7QA 4HJHA 5F9CA 1KYUA 1LWYA 3NA5A 3CVSA 3HS8A 2DKCA 2QLVA 1QTSA 2IV8A 1UT4A 2HZSA 3DPUA 1TBPA 3ENCA 5AN4A 1R4XA 1K2YX 4BJUA 3KTUA 1YTFA 4RODB 1VOLB 2EHBD 5JMVD 1MPGA 2NVMA 1KYDA 1WQAA 3RSMA 2NLVA 2OOYA 1AISA 5BMNA 1MP9A 4B0AA 2ZFDB 3C04A 1KFIA 2H4LX 2H5AX 5HSHA 3I0WA 3D4VA 1EBMA 2QREA 3SNSA 2QR1A 2V8QA 3I0XA 1VKLA 2NOBA 1PCJX 3CWAA 1QN8A 1KY7A 2D0AA 2MZ8A 2D0CA 2HZMA 2Z8UA 4EALA 4EAKA 1PCZA 1TGHA 2I5WA 1KY6A 2FKMX 5BMPA 1RM1A 2FUVA 1E42A 1B9KA 1W80A 3VN5A 4WZSD 1PZDA 3CWTA 1JDYA 3UW2A 3IH7A 1M3HA 1D3UA 2NOLA 1VTOA 1QN5A 1N3CA 4QG5A 1NVPA 2YA3A 2NOHA 1N3AA 3OSEA 2DKAA 1QNEA 1YQLA 1QTPA 4WX8A 5IYBP 3H1ZA 1HU0A 1J3MA 3CVTA 3PDKA 4WXAA 1LXTA 3CWUA 1QNCA 2D0BA 1T6AA 4ROEB 2IV9A 2NOIA 2QRCA 4D7RA 1QNAA 2VJ0A 1C9BB 4PY5A 3ULXA 1QN4A 5KL0A 1M5Q1 2PWWA 2NOEA 1UL7A 4Q11A 1TBAB
chains in the Genus database with same CATH topology
3TE5A 2Y8LA 2QLVA 4EAGA 3T4NA 4EAIA 3TDHA 2YA3A 3OSEA 2EHBD 2OOYA 2V9JA 2QRDA 2ZFDB 2Y8QA 2QREA 2V92A 2QR1A 2V8QA 2QRCA 4EAJA 4EALA 4EAKA 1V5SA 1UL7A 4CFFA 2OOXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TE5 A;  2Y8L A;  2QLV A;  4EAG A;  3T4N A;  4EAI A;  3TDH A;  2YA3 A;  3OSE A;  2EHB D;  2OOY A;  2V9J A;  2QRD A;  2ZFD B;  2Y8Q A;  2QRE A;  2V92 A;  2QR1 A;  2V8Q A;  2QRC A;  4EAJ A;  4EAL A;  4EAK A;  1V5S A;  1UL7 A;  4CFF A;  2OOX A; 
#chains in the Genus database with same CATH topology
 3CW7 A;  3OH6 A;  1TUO A;  2Y8L A;  3ASM A;  1KFQ A;  2XHI A;  1KO9 A;  2JOI A;  5EPC A;  1PCM X;  1XSZ A;  3OLP A;  3T4N A;  3CWS A;  4EJZ A;  3TDH A;  3ENO C;  3EIK A;  1VTL E;  1QNB A;  3HS9 A;  3I3W A;  1FN7 A;  2HL8 A;  1K35 A;  2FGT A;  2LAE A;  2V9J A;  2QRD A;  1VOK A;  2JHN A;  2Y8Q A;  1C47 A;  2V92 A;  4D7Q A;  1P5G X;  1CDW A;  2MJ7 A;  4TPS A;  1DIZ A;  4EAJ A;  1Q9U A;  1V5S A;  1EUV A;  1YQK A;  2JPI A;  2HKP A;  4CFF A;  2OOX A;  1QN7 A;  3OC3 C;  1QN6 A;  5JN5 A;  4I8O A;  2YH5 A;  1LWV A;  2JHJ A;  3TE5 A;  2NWV A;  1YQR A;  3OCI A;  4IL8 A;  1YQM A;  4EJY A;  5IYD P;  3F0Z A;  4EAG A;  3DPT A;  3KRM A;  2G30 A;  3OGD A;  1YTB A;  4MRQ A;  4EAI A;  2NOF A;  1NGM A;  1JFI C;  3OSM A;  1LWW A;  1QN9 A;  1PVS A;  3PMG A;  1KYF A;  2DKD A;  3BKQ X;  2Z0F A;  4ROC B;  3EAY A;  2O3O A;  1NH2 A;  3F10 A;  2F7L A;  3RPJ A;  4C7P A;  2NOZ A;  2HL9 A;  1WJW A;  3OH9 A;  1C4G A;  1N39 A;  2R5X A;  3N89 A;  2FKF A;  1P5D X;  3OST A;  4DUL A;  5IYC P;  1M3Q A;  1QN3 A;  1UT7 A;  3D7Q A;  4HJH A;  5F9C A;  1KYU A;  1LWY A;  3NA5 A;  3CVS A;  3HS8 A;  2DKC A;  2QLV A;  1QTS A;  2IV8 A;  1UT4 A;  2HZS A;  3DPU A;  1TBP A;  3ENC A;  5AN4 A;  1R4X A;  1K2Y X;  4BJU A;  3KTU A;  1YTF A;  4ROD B;  1VOL B;  2EHB D;  5JMV D;  1MPG A;  2NVM A;  1KYD A;  1WQA A;  3RSM A;  2NLV A;  2OOY A;  1AIS A;  5BMN A;  1MP9 A;  4B0A A;  2ZFD B;  3C04 A;  1KFI A;  2H4L X;  2H5A X;  5HSH A;  3I0W A;  3D4V A;  1EBM A;  2QRE A;  3SNS A;  2QR1 A;  2V8Q A;  3I0X A;  1VKL A;  2NOB A;  1PCJ X;  3CWA A;  1QN8 A;  1KY7 A;  2D0A A;  2MZ8 A;  2D0C A;  2HZM A;  2Z8U A;  4EAL A;  4EAK A;  1PCZ A;  1TGH A;  2I5W A;  1KY6 A;  2FKM X;  5BMP A;  1RM1 A;  2FUV A;  1E42 A;  1B9K A;  1W80 A;  3VN5 A;  4WZS D;  1PZD A;  3CWT A;  1JDY A;  3UW2 A;  3IH7 A;  1M3H A;  1D3U A;  2NOL A;  1VTO A;  1QN5 A;  1N3C A;  4QG5 A;  1NVP A;  2YA3 A;  2NOH A;  1N3A A;  3OSE A;  2DKA A;  1QNE A;  1YQL A;  1QTP A;  4WX8 A;  5IYB P;  3H1Z A;  1HU0 A;  1J3M A;  3CVT A;  3PDK A;  4WXA A;  1LXT A;  3CWU A;  1QNC A;  2D0B A;  1T6A A;  4ROE B;  2IV9 A;  2NOI A;  2QRC A;  4D7R A;  1QNA A;  2VJ0 A;  1C9B B;  4PY5 A;  3ULX A;  1QN4 A;  5KL0 A;  1M5Q 1;  2PWW A;  2NOE A;  1UL7 A;  4Q11 A;  1TBA B; 
#chains in the Genus database with same CATH homology
 3TE5 A;  2Y8L A;  2QLV A;  4EAG A;  3T4N A;  4EAI A;  3TDH A;  2YA3 A;  3OSE A;  2EHB D;  2OOY A;  2V9J A;  2QRD A;  2ZFD B;  2Y8Q A;  2QRE A;  2V92 A;  2QR1 A;  2V8Q A;  2QRC A;  4EAJ A;  4EAL A;  4EAK A;  1V5S A;  1UL7 A;  4CFF A;  2OOX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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