5EPCA

Crystal structure of wild-type human phosphoglucomutase 1
Total Genus 188
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
188
sequence length
564
structure length
561
Chain Sequence
SNMVKIVTVKTQAYQDQKPGTSGLRKRVKVFQSSANYAENFIQSIISTVEPAQRQEATLVVGGDGRFYMKEAIQLIARIAAANGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTASHNPGGPNGDFGIKFNISNGGPAPEAITDKIFQISKTIEEYAVCPDLKVDLGVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRSIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEDFGGHHPDPNLTYAADLVETMKSGEHDFGAAFDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMPTSGALDRVASATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGAGATIRLYIDSYEKDVAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Isomerase
molecule keywords Phosphoglucomutase-1
publication title Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency.
pubmed doi rcsb
source organism Homo sapiens
total genus 188
structure length 561
sequence length 564
chains with identical sequence B
ec nomenclature ec 5.4.2.2: Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
pdb deposition date 2015-11-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00408 PGM_PMM_IV Phosphoglucomutase/phosphomannomutase, C-terminal domain
A PF02878 PGM_PMM_I Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
A PF02879 PGM_PMM_II Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
A PF02880 PGM_PMM_III Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.50 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Alpha-D-phosphohexomutase, C-terminal domain 5epcA04
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5epcA02
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5epcA03
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5epcA01
1JDYA 1PCJX 3NA5A 5EPCA 3OLPA 5HSHA 5JN5A 1K2YX 3UW2A 2FUVA 1P5DX 5KL0A 1C47A 2H4LX 2DKAA 3BKQX 4MRQA 1K35A 1WQAA 5F9CA 3I3WA 3RSMA 5BMNA 2EIUA 2FKMX 1P5GX 2FKFA 1C4GA 2H5AX 2EHPA 1LXTA 3ENCA 1KFQA 3ENOC 3C04A 1TUOA 1PCMX 4BJUA 3PDKA 5JMVD 5BMPA 1WJWA 4HJHA 2Z0FA 4WX8A 2DKCA 4IL8A 1VKLA 2F7LA 1KFIA 2JPIA 4WXAA 2DKDA 4QG5A 3PMGA
chains in the Genus database with same CATH superfamily
1PCJX 5HSHA 3H1ZA 2IV9A 3HS8A 2QR1A 3CWSA 1Q9UA 1QN3A 2NOEA 3I0WA 1KYUA 2DKAA 4PY5A 2NOFA 3TE5A 3BKQX 4MRQA 1PZDA 1WQAA 5F9CA 3I3WA 4B0AA 2JOIA 3CWAA 1AISA 2H5AX 2Z8UA 3DPTA 3ENOC 3OH9A 2D0CA 1TUOA 2NVMA 1VTOA 1C9BB 2NWVA 2YH5A 5JMVD 1YQLA 4HJHA 3KTUA 3EAYA 1QN7A 4TPSA 2HKPA 4IL8A 2F7LA 2D0AA 1M3QA 1M5Q1 2V8QA 3OSMA 1N3CA 1QNCA 2HL8A 4RODB 1JDYA 2MZ8A 1JFIC 5JN5A 1QN6A 3UW2A 2FUVA 4EJYA 1QN9A 1C47A 5IYDP 4ROCB 4QG5A 4DULA 2O3OA 1QNAA 2NLVA 3CVTA 2QLVA 5BMNA 1VTLE 1HU0A 1LWYA 1QN8A 3CWTA 1KY7A 1EBMA 3CW7A 2FKFA 3D4VA 2D0BA 2YA3A 1KFQA 3PMGA 3C04A 4EAIA 1EUVA 1PCMX 4BJUA 1VOLB 4D7QA 1E42A 1WJWA 1B9KA 2Z0FA 1QTPA 3N89A 2HZMA 1W80A 2JHNA 4WX8A 2DKCA 1M3HA 1VKLA 3T4NA 5IYCP 2JPIA 1XSZA 2V9JA 3VN5A 1YQRA 1KYDA 3SNSA 3NA5A 3OLPA 4CFFA 3ASMA 2JHJA 2HZSA 2VJ0A 2Y8QA 3OSTA 4I8OA 4EAJA 1RM1A 1YQKA 1QTSA 1TGHA 2NOBA 2PWWA 2QRCA 3OH6A 1YTFA 2HL9A 2XHIA 1N39A 1NH2A 1N3AA 2EHBD 3OGDA 2FGTA 2EIUA 2FKMX 1P5GX 1UL7A 3TDHA 2V92A 2R5XA 4C7PA 4WZSD 1KY6A 1UT4A 1YTBA 4EJZA 2Y8LA 3PDKA 3F0ZA 1D3UA 3CWUA 2IV8A 1LWWA 1UT7A 3EIKA 4Q11A 3D7QA 1MPGA 2NOLA 2NOZA 3OSEA 3ULXA 1KO9A 2DKDA 4EAKA 5AN4A 5EPCA 1J3MA 2NOHA 1K2YX 1QN5A 4ROEB 1P5DX 1TBAB 5KL0A 3OCIA 1QNEA 1PVSA 1T6AA 1VOKA 2H4LX 2NOIA 3I0XA 1FN7A 1K35A 3CVSA 3RSMA 2MJ7A 1NVPA 1NGMA 3OC3C 2ZFDB 5IYBP 1C4GA 1CDWA 2EHPA 4EAGA 2I5WA 1QN4A 1LXTA 3F10A 3ENCA 1R4XA 3IH7A 1YQMA 3RPJA 2G30A 2QRDA 4EALA 5BMPA 2OOXA 2QREA 1LWVA 1QNBA 2LAEA 1MP9A 1V5SA 1KFIA 3HS9A 4D7RA 1PCZA 4WXAA 2OOYA 3KRMA 1TBPA 3DPUA 1DIZA 1KYFA
chains in the Genus database with same CATH topology
1JDYA 1PCJX 3NA5A 5EPCA 3OLPA 5HSHA 5JN5A 1K2YX 3UW2A 2FUVA 1P5DX 5KL0A 1C47A 2H4LX 2DKAA 3BKQX 4MRQA 1K35A 1WQAA 5F9CA 3I3WA 3RSMA 5BMNA 2EIUA 2FKMX 1P5GX 2FKFA 1C4GA 2H5AX 2EHPA 1LXTA 3ENCA 1KFQA 3ENOC 3C04A 1TUOA 1PCMX 4BJUA 3PDKA 5JMVD 5BMPA 1WJWA 4HJHA 2Z0FA 4WX8A 2DKCA 4IL8A 1VKLA 2F7LA 1KFIA 2JPIA 4WXAA 2DKDA 4QG5A 3PMGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JDY A;  1PCJ X;  3NA5 A;  5EPC A;  3OLP A;  5HSH A;  5JN5 A;  1K2Y X;  3UW2 A;  2FUV A;  1P5D X;  5KL0 A;  1C47 A;  2H4L X;  2DKA A;  3BKQ X;  4MRQ A;  1K35 A;  1WQA A;  5F9C A;  3I3W A;  3RSM A;  5BMN A;  2EIU A;  2FKM X;  1P5G X;  2FKF A;  1C4G A;  2H5A X;  2EHP A;  1LXT A;  3ENC A;  1KFQ A;  3ENO C;  3C04 A;  1TUO A;  1PCM X;  4BJU A;  3PDK A;  5JMV D;  5BMP A;  1WJW A;  4HJH A;  2Z0F A;  4WX8 A;  2DKC A;  4IL8 A;  1VKL A;  2F7L A;  1KFI A;  2JPI A;  4WXA A;  2DKD A;  4QG5 A;  3PMG A; 
#chains in the Genus database with same CATH topology
 1PCJ X;  5HSH A;  3H1Z A;  2IV9 A;  3HS8 A;  2QR1 A;  3CWS A;  1Q9U A;  1QN3 A;  2NOE A;  3I0W A;  1KYU A;  2DKA A;  4PY5 A;  2NOF A;  3TE5 A;  3BKQ X;  4MRQ A;  1PZD A;  1WQA A;  5F9C A;  3I3W A;  4B0A A;  2JOI A;  3CWA A;  1AIS A;  2H5A X;  2Z8U A;  3DPT A;  3ENO C;  3OH9 A;  2D0C A;  1TUO A;  2NVM A;  1VTO A;  1C9B B;  2NWV A;  2YH5 A;  5JMV D;  1YQL A;  4HJH A;  3KTU A;  3EAY A;  1QN7 A;  4TPS A;  2HKP A;  4IL8 A;  2F7L A;  2D0A A;  1M3Q A;  1M5Q 1;  2V8Q A;  3OSM A;  1N3C A;  1QNC A;  2HL8 A;  4ROD B;  1JDY A;  2MZ8 A;  1JFI C;  5JN5 A;  1QN6 A;  3UW2 A;  2FUV A;  4EJY A;  1QN9 A;  1C47 A;  5IYD P;  4ROC B;  4QG5 A;  4DUL A;  2O3O A;  1QNA A;  2NLV A;  3CVT A;  2QLV A;  5BMN A;  1VTL E;  1HU0 A;  1LWY A;  1QN8 A;  3CWT A;  1KY7 A;  1EBM A;  3CW7 A;  2FKF A;  3D4V A;  2D0B A;  2YA3 A;  1KFQ A;  3PMG A;  3C04 A;  4EAI A;  1EUV A;  1PCM X;  4BJU A;  1VOL B;  4D7Q A;  1E42 A;  1WJW A;  1B9K A;  2Z0F A;  1QTP A;  3N89 A;  2HZM A;  1W80 A;  2JHN A;  4WX8 A;  2DKC A;  1M3H A;  1VKL A;  3T4N A;  5IYC P;  2JPI A;  1XSZ A;  2V9J A;  3VN5 A;  1YQR A;  1KYD A;  3SNS A;  3NA5 A;  3OLP A;  4CFF A;  3ASM A;  2JHJ A;  2HZS A;  2VJ0 A;  2Y8Q A;  3OST A;  4I8O A;  4EAJ A;  1RM1 A;  1YQK A;  1QTS A;  1TGH A;  2NOB A;  2PWW A;  2QRC A;  3OH6 A;  1YTF A;  2HL9 A;  2XHI A;  1N39 A;  1NH2 A;  1N3A A;  2EHB D;  3OGD A;  2FGT A;  2EIU A;  2FKM X;  1P5G X;  1UL7 A;  3TDH A;  2V92 A;  2R5X A;  4C7P A;  4WZS D;  1KY6 A;  1UT4 A;  1YTB A;  4EJZ A;  2Y8L A;  3PDK A;  3F0Z A;  1D3U A;  3CWU A;  2IV8 A;  1LWW A;  1UT7 A;  3EIK A;  4Q11 A;  3D7Q A;  1MPG A;  2NOL A;  2NOZ A;  3OSE A;  3ULX A;  1KO9 A;  2DKD A;  4EAK A;  5AN4 A;  5EPC A;  1J3M A;  2NOH A;  1K2Y X;  1QN5 A;  4ROE B;  1P5D X;  1TBA B;  5KL0 A;  3OCI A;  1QNE A;  1PVS A;  1T6A A;  1VOK A;  2H4L X;  2NOI A;  3I0X A;  1FN7 A;  1K35 A;  3CVS A;  3RSM A;  2MJ7 A;  1NVP A;  1NGM A;  3OC3 C;  2ZFD B;  5IYB P;  1C4G A;  1CDW A;  2EHP A;  4EAG A;  2I5W A;  1QN4 A;  1LXT A;  3F10 A;  3ENC A;  1R4X A;  3IH7 A;  1YQM A;  3RPJ A;  2G30 A;  2QRD A;  4EAL A;  5BMP A;  2OOX A;  2QRE A;  1LWV A;  1QNB A;  2LAE A;  1MP9 A;  1V5S A;  1KFI A;  3HS9 A;  4D7R A;  1PCZ A;  4WXA A;  2OOY A;  3KRM A;  1TBP A;  3DPU A;  1DIZ A;  1KYF A; 
#chains in the Genus database with same CATH homology
 1JDY A;  1PCJ X;  3NA5 A;  5EPC A;  3OLP A;  5HSH A;  5JN5 A;  1K2Y X;  3UW2 A;  2FUV A;  1P5D X;  5KL0 A;  1C47 A;  2H4L X;  2DKA A;  3BKQ X;  4MRQ A;  1K35 A;  1WQA A;  5F9C A;  3I3W A;  3RSM A;  5BMN A;  2EIU A;  2FKM X;  1P5G X;  2FKF A;  1C4G A;  2H5A X;  2EHP A;  1LXT A;  3ENC A;  1KFQ A;  3ENO C;  3C04 A;  1TUO A;  1PCM X;  4BJU A;  3PDK A;  5JMV D;  5BMP A;  1WJW A;  4HJH A;  2Z0F A;  4WX8 A;  2DKC A;  4IL8 A;  1VKL A;  2F7L A;  1KFI A;  2JPI A;  4WXA A;  2DKD A;  4QG5 A;  3PMG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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