5HSHA

Crystal structure of the g291r mutant of human phosphoglucomutase 1
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
sequence length
562
structure length
535
Chain Sequence
MVKIVTVKTQAYQDQKPGTSGLRKRVKVFQSSANYAENFIQSIISTVEPAQRQEATLVVGGDGYMKEAIQLIARIAAANGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTADFGIKFNISNGGPAPEAITDKIFQISKTIEEYAVCPDLKVDLGVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRSIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEYAADLVETMKSGEHDFGAAFDGDRDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMPTSGALDRVASATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSAGATIRLYIDSYEKDVAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Phosphoglucomutase-1
publication title Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Isomerase
total genus 162
structure length 535
sequence length 562
chains with identical sequence B
ec nomenclature ec 5.4.2.2: Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
pdb deposition date 2016-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00408 PGM_PMM_IV Phosphoglucomutase/phosphomannomutase, C-terminal domain
A PF02878 PGM_PMM_I Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
A PF02879 PGM_PMM_II Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
A PF02880 PGM_PMM_III Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.50 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Alpha-D-phosphohexomutase, C-terminal domain 5hshA04
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5hshA02
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5hshA03
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5hshA01
2F7LA 4QG5A 1LXTA 2JPIA 4WXAA 2EIUA 1K35A 1WJWA 1TUOA 1WQAA 1KFQA 1VKLA 5EPCA 3RSMA 2FUVA 1K2YX 5F9CA 4MRQA 5KL0A 2DKDA 1C4GA 3UW2A 4IL8A 4HJHA 1PCJX 3NA5A 2DKAA 3C04A 3BKQX 1P5GX 2DKCA 5BMPA 4WX8A 2H5AX 1KFIA 5BMNA 5JN5A 2EHPA 5HSHA 1P5DX 3ENOC 3ENCA 4BJUA 2Z0FA 1C47A 3PMGA 2H4LX 2FKMX 1JDYA 3OLPA 5JMVD 1PCMX 3PDKA 3I3WA 2FKFA
chains in the Genus database with same CATH superfamily
2R5XA 4QG5A 1KYFA 2I5WA 1KO9A 1LXTA 3HS8A 3CWSA 2OOXA 5IYBP 2EIUA 1M5Q1 1K35A 1WJWA 2IV9A 2OOYA 1M3QA 1W80A 1AISA 3RSMA 1PCZA 3KRMA 2PWWA 1M3HA 1MPGA 3CWUA 1EUVA 1Q9UA 4HJHA 1QN4A 3IH7A 3OH9A 1E42A 3EIKA 3F10A 3H1ZA 2Y8QA 2NOIA 2DKCA 4DULA 4WX8A 1NGMA 1QN5A 1QN9A 2G30A 3F0ZA 1DIZA 1N39A 1QN6A 4BJUA 1C9BB 1YQKA 3ULXA 2HL9A 2QLVA 4I8OA 2FKMX 2NLVA 1B9KA 2HL8A 2NOFA 2NOZA 2YH5A 1CDWA 2HZMA 2QR1A 1LWVA 2MZ8A 4Q11A 5IYCP 3CW7A 2FKFA 3DPUA 1VTOA 2VJ0A 2NOLA 1KY6A 4WXAA 1J3MA 4D7QA 3OSMA 3OC3C 3TDHA 4RODB 1FN7A 1QN3A 2NOEA 4EAGA 1QNAA 3KTUA 3OGDA 2V92A 4IL8A 1VOLB 1KYUA 1PCJX 3NA5A 2Z8UA 3BKQX 1JFIC 3N89A 1QTSA 3T4NA 3D4VA 1NH2A 1XSZA 2H5AX 2JHNA 1YTBA 1T6AA 5BMNA 1KY7A 5JN5A 1QN8A 1UL7A 2QRCA 5HSHA 1P5DX 3ENOC 3OH6A 4WZSD 4EAKA 4C7PA 2YA3A 3CWAA 4EAJA 2Z0FA 4EJYA 3PMGA 2H4LX 1QN7A 4ROEB 4ROCB 2D0AA 3I3WA 1UT4A 2F7LA 1HU0A 2NWVA 1V5SA 2JPIA 2EHBD 2NOBA 2JOIA 3SNSA 4D7RA 1TGHA 3HS9A 4TPSA 5EPCA 1WQAA 1N3AA 5F9CA 1KYDA 1K2YX 3ASMA 3I0XA 4MRQA 1MP9A 5KL0A 1QNEA 2DKDA 2ZFDB 3UW2A 1YTFA 2NOHA 2D0CA 1VTLE 2DKAA 3EAYA 1D3UA 5BMPA 1TBAB 3RPJA 4B0AA 2QREA 2XHIA 1N3CA 3OSEA 1VOKA 1YQMA 4CFFA 3TE5A 1C47A 5JMVD 3CVTA 4EAIA 2O3OA 4EALA 3OCIA 1R4XA 1QNCA 1EBMA 1NVPA 1QTPA 4PY5A 3CVSA 1TUOA 1KFQA 1VKLA 2FUVA 1YQRA 2V9JA 3OSTA 5AN4A 2D0BA 2FGTA 2MJ7A 1C4GA 3DPTA 4EJZA 1PVSA 3C04A 1P5GX 2NVMA 1LWWA 1YQLA 2HKPA 1KFIA 3VN5A 1LWYA 1PZDA 2EHPA 3D7QA 3I0WA 3ENCA 2QRDA 2HZSA 3CWTA 1JDYA 3OLPA 1PCMX 3PDKA 2LAEA 1TBPA 2IV8A 1UT7A 2V8QA 5IYDP 1RM1A 2Y8LA 1QNBA 2JHJA
chains in the Genus database with same CATH topology
2F7LA 4QG5A 1LXTA 2JPIA 4WXAA 2EIUA 1K35A 1WJWA 1TUOA 1WQAA 1KFQA 1VKLA 5EPCA 3RSMA 2FUVA 1K2YX 5F9CA 4MRQA 5KL0A 2DKDA 1C4GA 3UW2A 4IL8A 4HJHA 1PCJX 3NA5A 2DKAA 3C04A 3BKQX 1P5GX 2DKCA 5BMPA 4WX8A 2H5AX 1KFIA 5BMNA 5JN5A 2EHPA 5HSHA 1P5DX 3ENOC 3ENCA 4BJUA 2Z0FA 1C47A 3PMGA 2H4LX 2FKMX 1JDYA 3OLPA 5JMVD 1PCMX 3PDKA 3I3WA 2FKFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2F7L A;  4QG5 A;  1LXT A;  2JPI A;  4WXA A;  2EIU A;  1K35 A;  1WJW A;  1TUO A;  1WQA A;  1KFQ A;  1VKL A;  5EPC A;  3RSM A;  2FUV A;  1K2Y X;  5F9C A;  4MRQ A;  5KL0 A;  2DKD A;  1C4G A;  3UW2 A;  4IL8 A;  4HJH A;  1PCJ X;  3NA5 A;  2DKA A;  3C04 A;  3BKQ X;  1P5G X;  2DKC A;  5BMP A;  4WX8 A;  2H5A X;  1KFI A;  5BMN A;  5JN5 A;  2EHP A;  5HSH A;  1P5D X;  3ENO C;  3ENC A;  4BJU A;  2Z0F A;  1C47 A;  3PMG A;  2H4L X;  2FKM X;  1JDY A;  3OLP A;  5JMV D;  1PCM X;  3PDK A;  3I3W A;  2FKF A; 
#chains in the Genus database with same CATH topology
 2R5X A;  4QG5 A;  1KYF A;  2I5W A;  1KO9 A;  1LXT A;  3HS8 A;  3CWS A;  2OOX A;  5IYB P;  2EIU A;  1M5Q 1;  1K35 A;  1WJW A;  2IV9 A;  2OOY A;  1M3Q A;  1W80 A;  1AIS A;  3RSM A;  1PCZ A;  3KRM A;  2PWW A;  1M3H A;  1MPG A;  3CWU A;  1EUV A;  1Q9U A;  4HJH A;  1QN4 A;  3IH7 A;  3OH9 A;  1E42 A;  3EIK A;  3F10 A;  3H1Z A;  2Y8Q A;  2NOI A;  2DKC A;  4DUL A;  4WX8 A;  1NGM A;  1QN5 A;  1QN9 A;  2G30 A;  3F0Z A;  1DIZ A;  1N39 A;  1QN6 A;  4BJU A;  1C9B B;  1YQK A;  3ULX A;  2HL9 A;  2QLV A;  4I8O A;  2FKM X;  2NLV A;  1B9K A;  2HL8 A;  2NOF A;  2NOZ A;  2YH5 A;  1CDW A;  2HZM A;  2QR1 A;  1LWV A;  2MZ8 A;  4Q11 A;  5IYC P;  3CW7 A;  2FKF A;  3DPU A;  1VTO A;  2VJ0 A;  2NOL A;  1KY6 A;  4WXA A;  1J3M A;  4D7Q A;  3OSM A;  3OC3 C;  3TDH A;  4ROD B;  1FN7 A;  1QN3 A;  2NOE A;  4EAG A;  1QNA A;  3KTU A;  3OGD A;  2V92 A;  4IL8 A;  1VOL B;  1KYU A;  1PCJ X;  3NA5 A;  2Z8U A;  3BKQ X;  1JFI C;  3N89 A;  1QTS A;  3T4N A;  3D4V A;  1NH2 A;  1XSZ A;  2H5A X;  2JHN A;  1YTB A;  1T6A A;  5BMN A;  1KY7 A;  5JN5 A;  1QN8 A;  1UL7 A;  2QRC A;  5HSH A;  1P5D X;  3ENO C;  3OH6 A;  4WZS D;  4EAK A;  4C7P A;  2YA3 A;  3CWA A;  4EAJ A;  2Z0F A;  4EJY A;  3PMG A;  2H4L X;  1QN7 A;  4ROE B;  4ROC B;  2D0A A;  3I3W A;  1UT4 A;  2F7L A;  1HU0 A;  2NWV A;  1V5S A;  2JPI A;  2EHB D;  2NOB A;  2JOI A;  3SNS A;  4D7R A;  1TGH A;  3HS9 A;  4TPS A;  5EPC A;  1WQA A;  1N3A A;  5F9C A;  1KYD A;  1K2Y X;  3ASM A;  3I0X A;  4MRQ A;  1MP9 A;  5KL0 A;  1QNE A;  2DKD A;  2ZFD B;  3UW2 A;  1YTF A;  2NOH A;  2D0C A;  1VTL E;  2DKA A;  3EAY A;  1D3U A;  5BMP A;  1TBA B;  3RPJ A;  4B0A A;  2QRE A;  2XHI A;  1N3C A;  3OSE A;  1VOK A;  1YQM A;  4CFF A;  3TE5 A;  1C47 A;  5JMV D;  3CVT A;  4EAI A;  2O3O A;  4EAL A;  3OCI A;  1R4X A;  1QNC A;  1EBM A;  1NVP A;  1QTP A;  4PY5 A;  3CVS A;  1TUO A;  1KFQ A;  1VKL A;  2FUV A;  1YQR A;  2V9J A;  3OST A;  5AN4 A;  2D0B A;  2FGT A;  2MJ7 A;  1C4G A;  3DPT A;  4EJZ A;  1PVS A;  3C04 A;  1P5G X;  2NVM A;  1LWW A;  1YQL A;  2HKP A;  1KFI A;  3VN5 A;  1LWY A;  1PZD A;  2EHP A;  3D7Q A;  3I0W A;  3ENC A;  2QRD A;  2HZS A;  3CWT A;  1JDY A;  3OLP A;  1PCM X;  3PDK A;  2LAE A;  1TBP A;  2IV8 A;  1UT7 A;  2V8Q A;  5IYD P;  1RM1 A;  2Y8L A;  1QNB A;  2JHJ A; 
#chains in the Genus database with same CATH homology
 2F7L A;  4QG5 A;  1LXT A;  2JPI A;  4WXA A;  2EIU A;  1K35 A;  1WJW A;  1TUO A;  1WQA A;  1KFQ A;  1VKL A;  5EPC A;  3RSM A;  2FUV A;  1K2Y X;  5F9C A;  4MRQ A;  5KL0 A;  2DKD A;  1C4G A;  3UW2 A;  4IL8 A;  4HJH A;  1PCJ X;  3NA5 A;  2DKA A;  3C04 A;  3BKQ X;  1P5G X;  2DKC A;  5BMP A;  4WX8 A;  2H5A X;  1KFI A;  5BMN A;  5JN5 A;  2EHP A;  5HSH A;  1P5D X;  3ENO C;  3ENC A;  4BJU A;  2Z0F A;  1C47 A;  3PMG A;  2H4L X;  2FKM X;  1JDY A;  3OLP A;  5JMV D;  1PCM X;  3PDK A;  3I3W A;  2FKF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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