5HSHA

Crystal structure of the g291r mutant of human phosphoglucomutase 1
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
sequence length
562
structure length
535
Chain Sequence
MVKIVTVKTQAYQDQKPGTSGLRKRVKVFQSSANYAENFIQSIISTVEPAQRQEATLVVGGDGYMKEAIQLIARIAAANGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTADFGIKFNISNGGPAPEAITDKIFQISKTIEEYAVCPDLKVDLGVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRSIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEYAADLVETMKSGEHDFGAAFDGDRDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMPTSGALDRVASATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSAGATIRLYIDSYEKDVAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Isomerase
molecule keywords Phosphoglucomutase-1
publication title Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency.
pubmed doi rcsb
source organism Homo sapiens
total genus 162
structure length 535
sequence length 562
chains with identical sequence B
ec nomenclature ec 5.4.2.2: Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
pdb deposition date 2016-01-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00408 PGM_PMM_IV Phosphoglucomutase/phosphomannomutase, C-terminal domain
A PF02878 PGM_PMM_I Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
A PF02879 PGM_PMM_II Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
A PF02880 PGM_PMM_III Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.50 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Alpha-D-phosphohexomutase, C-terminal domain 5hshA04
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5hshA02
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5hshA03
3.40.120.10 Alpha Beta 3-Layer(aba) Sandwich Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3 5hshA01
1C4GA 2DKAA 2FUVA 3I3WA 2H5AX 2JPIA 4WX8A 2FKMX 3RSMA 5F9CA 2FKFA 1PCMX 4QG5A 3UW2A 1WJWA 5JN5A 4WXAA 1KFQA 2Z0FA 3BKQX 4MRQA 4IL8A 2DKCA 3PDKA 1PCJX 1P5DX 5JMVD 1WQAA 1K2YX 1C47A 1LXTA 3ENOC 3C04A 3OLPA 3NA5A 5BMNA 5KL0A 1JDYA 1KFIA 1TUOA 5BMPA 2DKDA 3ENCA 1VKLA 4BJUA 5EPCA 2H4LX 5HSHA 3PMGA 2F7LA 1K35A 4HJHA 1P5GX 2EHPA 2EIUA
chains in the Genus database with same CATH superfamily
4EAGA 4RODB 2NOFA 1TBAB 2JPIA 3F10A 4CFFA 1KYFA 3DPUA 5F9CA 1Q9UA 3I0WA 1QNAA 2HL8A 1PCMX 2NVMA 2MJ7A 3UW2A 5JN5A 3N89A 2NLVA 1QTSA 1VOKA 2Z0FA 2HKPA 3OSTA 4MRQA 1QNBA 2NOBA 2Y8LA 2IV9A 1PZDA 2D0CA 5JMVD 1J3MA 1QN9A 1K2YX 2YA3A 3C04A 3HS8A 3NA5A 1KO9A 5BMNA 1R4XA 1UL7A 1TUOA 1YQMA 3TE5A 1VOLB 1RM1A 1MPGA 1M3HA 4WZSD 2V8QA 4Q11A 2NOEA 1QN8A 3D7QA 2EHPA 1UT7A 2DKAA 4ROCB 3RSMA 4D7QA 1NH2A 1D3UA 2R5XA 1QN7A 2JOIA 1WJWA 2NOLA 3T4NA 3VN5A 2QRDA 4WXAA 2XHIA 1AISA 1QN3A 1TBPA 3CWAA 4EJZA 4EJYA 3OH9A 1LWYA 2V92A 3PDKA 2HL9A 1FN7A 1VTOA 1KY6A 3OH6A 2HZSA 3OLPA 1EBMA 1JDYA 1KFIA 3KRMA 2Z8UA 2DKDA 1TGHA 2D0AA 1HU0A 1VKLA 1B9KA 2H4LX 5HSHA 1DIZA 3CVTA 4I8OA 2O3OA 3IH7A 1E42A 1UT4A 1C4GA 3CVSA 2FUVA 1PVSA 2H5AX 5IYCP 2FKMX 3OSEA 1KYDA 1T6AA 2OOXA 1N39A 2EHBD 2YH5A 4ROEB 3CWTA 1QN6A 3CWUA 3SNSA 3RPJA 2IV8A 1N3CA 3BKQX 4C7PA 3D4VA 1CDWA 4IL8A 3ASMA 1EUVA 1PCJX 3HS9A 5IYDP 1M3QA 1LXTA 2QRCA 2ZFDB 3ENOC 1KYUA 1MP9A 4EAKA 1YQRA 4EAJA 1NGMA 2JHJA 5KL0A 5BMPA 3ENCA 3OC3C 2D0BA 3OSMA 1N3AA 1KY7A 3EAYA 1C9BB 1QN4A 2QR1A 3CWSA 1M5Q1 2F7LA 4TPSA 4HJHA 1P5GX 3OGDA 1QNCA 2EIUA 2VJ0A 3DPTA 2QREA 3I3WA 4WX8A 2V9JA 4PY5A 1YQLA 2FKFA 1VTLE 3EIKA 4DULA 4EALA 2MZ8A 4B0AA 1KFQA 3CW7A 1W80A 1QNEA 2JHNA 3I0XA 2FGTA 2DKCA 1QN5A 3TDHA 2G30A 2Y8QA 2OOYA 3OCIA 1P5DX 1NVPA 1YTFA 1WQAA 1XSZA 1QTPA 1C47A 2NWVA 3H1ZA 3F0ZA 2NOZA 2PWWA 4D7RA 2I5WA 2NOHA 3ULXA 1V5SA 2HZMA 2LAEA 4BJUA 1LWVA 1LWWA 1JFIC 5EPCA 4EAIA 1YQKA 1YTBA 2NOIA 1PCZA 3PMGA 1K35A 4QG5A 2QLVA 3KTUA 5AN4A 5IYBP
chains in the Genus database with same CATH topology
1C4GA 2DKAA 2FUVA 3I3WA 2H5AX 2JPIA 4WX8A 2FKMX 3RSMA 5F9CA 2FKFA 1PCMX 4QG5A 3UW2A 1WJWA 5JN5A 4WXAA 1KFQA 2Z0FA 3BKQX 4MRQA 4IL8A 2DKCA 3PDKA 1PCJX 1P5DX 5JMVD 1WQAA 1K2YX 1C47A 1LXTA 3ENOC 3C04A 3OLPA 3NA5A 5BMNA 5KL0A 1JDYA 1KFIA 1TUOA 5BMPA 2DKDA 3ENCA 1VKLA 4BJUA 5EPCA 2H4LX 5HSHA 3PMGA 2F7LA 1K35A 4HJHA 1P5GX 2EHPA 2EIUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C4G A;  2DKA A;  2FUV A;  3I3W A;  2H5A X;  2JPI A;  4WX8 A;  2FKM X;  3RSM A;  5F9C A;  2FKF A;  1PCM X;  4QG5 A;  3UW2 A;  1WJW A;  5JN5 A;  4WXA A;  1KFQ A;  2Z0F A;  3BKQ X;  4MRQ A;  4IL8 A;  2DKC A;  3PDK A;  1PCJ X;  1P5D X;  5JMV D;  1WQA A;  1K2Y X;  1C47 A;  1LXT A;  3ENO C;  3C04 A;  3OLP A;  3NA5 A;  5BMN A;  5KL0 A;  1JDY A;  1KFI A;  1TUO A;  5BMP A;  2DKD A;  3ENC A;  1VKL A;  4BJU A;  5EPC A;  2H4L X;  5HSH A;  3PMG A;  2F7L A;  1K35 A;  4HJH A;  1P5G X;  2EHP A;  2EIU A; 
#chains in the Genus database with same CATH topology
 4EAG A;  4ROD B;  2NOF A;  1TBA B;  2JPI A;  3F10 A;  4CFF A;  1KYF A;  3DPU A;  5F9C A;  1Q9U A;  3I0W A;  1QNA A;  2HL8 A;  1PCM X;  2NVM A;  2MJ7 A;  3UW2 A;  5JN5 A;  3N89 A;  2NLV A;  1QTS A;  1VOK A;  2Z0F A;  2HKP A;  3OST A;  4MRQ A;  1QNB A;  2NOB A;  2Y8L A;  2IV9 A;  1PZD A;  2D0C A;  5JMV D;  1J3M A;  1QN9 A;  1K2Y X;  2YA3 A;  3C04 A;  3HS8 A;  3NA5 A;  1KO9 A;  5BMN A;  1R4X A;  1UL7 A;  1TUO A;  1YQM A;  3TE5 A;  1VOL B;  1RM1 A;  1MPG A;  1M3H A;  4WZS D;  2V8Q A;  4Q11 A;  2NOE A;  1QN8 A;  3D7Q A;  2EHP A;  1UT7 A;  2DKA A;  4ROC B;  3RSM A;  4D7Q A;  1NH2 A;  1D3U A;  2R5X A;  1QN7 A;  2JOI A;  1WJW A;  2NOL A;  3T4N A;  3VN5 A;  2QRD A;  4WXA A;  2XHI A;  1AIS A;  1QN3 A;  1TBP A;  3CWA A;  4EJZ A;  4EJY A;  3OH9 A;  1LWY A;  2V92 A;  3PDK A;  2HL9 A;  1FN7 A;  1VTO A;  1KY6 A;  3OH6 A;  2HZS A;  3OLP A;  1EBM A;  1JDY A;  1KFI A;  3KRM A;  2Z8U A;  2DKD A;  1TGH A;  2D0A A;  1HU0 A;  1VKL A;  1B9K A;  2H4L X;  5HSH A;  1DIZ A;  3CVT A;  4I8O A;  2O3O A;  3IH7 A;  1E42 A;  1UT4 A;  1C4G A;  3CVS A;  2FUV A;  1PVS A;  2H5A X;  5IYC P;  2FKM X;  3OSE A;  1KYD A;  1T6A A;  2OOX A;  1N39 A;  2EHB D;  2YH5 A;  4ROE B;  3CWT A;  1QN6 A;  3CWU A;  3SNS A;  3RPJ A;  2IV8 A;  1N3C A;  3BKQ X;  4C7P A;  3D4V A;  1CDW A;  4IL8 A;  3ASM A;  1EUV A;  1PCJ X;  3HS9 A;  5IYD P;  1M3Q A;  1LXT A;  2QRC A;  2ZFD B;  3ENO C;  1KYU A;  1MP9 A;  4EAK A;  1YQR A;  4EAJ A;  1NGM A;  2JHJ A;  5KL0 A;  5BMP A;  3ENC A;  3OC3 C;  2D0B A;  3OSM A;  1N3A A;  1KY7 A;  3EAY A;  1C9B B;  1QN4 A;  2QR1 A;  3CWS A;  1M5Q 1;  2F7L A;  4TPS A;  4HJH A;  1P5G X;  3OGD A;  1QNC A;  2EIU A;  2VJ0 A;  3DPT A;  2QRE A;  3I3W A;  4WX8 A;  2V9J A;  4PY5 A;  1YQL A;  2FKF A;  1VTL E;  3EIK A;  4DUL A;  4EAL A;  2MZ8 A;  4B0A A;  1KFQ A;  3CW7 A;  1W80 A;  1QNE A;  2JHN A;  3I0X A;  2FGT A;  2DKC A;  1QN5 A;  3TDH A;  2G30 A;  2Y8Q A;  2OOY A;  3OCI A;  1P5D X;  1NVP A;  1YTF A;  1WQA A;  1XSZ A;  1QTP A;  1C47 A;  2NWV A;  3H1Z A;  3F0Z A;  2NOZ A;  2PWW A;  4D7R A;  2I5W A;  2NOH A;  3ULX A;  1V5S A;  2HZM A;  2LAE A;  4BJU A;  1LWV A;  1LWW A;  1JFI C;  5EPC A;  4EAI A;  1YQK A;  1YTB A;  2NOI A;  1PCZ A;  3PMG A;  1K35 A;  4QG5 A;  2QLV A;  3KTU A;  5AN4 A;  5IYB P; 
#chains in the Genus database with same CATH homology
 1C4G A;  2DKA A;  2FUV A;  3I3W A;  2H5A X;  2JPI A;  4WX8 A;  2FKM X;  3RSM A;  5F9C A;  2FKF A;  1PCM X;  4QG5 A;  3UW2 A;  1WJW A;  5JN5 A;  4WXA A;  1KFQ A;  2Z0F A;  3BKQ X;  4MRQ A;  4IL8 A;  2DKC A;  3PDK A;  1PCJ X;  1P5D X;  5JMV D;  1WQA A;  1K2Y X;  1C47 A;  1LXT A;  3ENO C;  3C04 A;  3OLP A;  3NA5 A;  5BMN A;  5KL0 A;  1JDY A;  1KFI A;  1TUO A;  5BMP A;  2DKD A;  3ENC A;  1VKL A;  4BJU A;  5EPC A;  2H4L X;  5HSH A;  3PMG A;  2F7L A;  1K35 A;  4HJH A;  1P5G X;  2EHP A;  2EIU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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