4EAKA

Co-crystal structure of an ampk core with atp
Total Genus 21
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
99
structure length
92
Chain Sequence
WHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDGSHTIEFFEMCANLIKILAQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
pubmed doi rcsb
molecule tags Transferase
source organism Rattus norvegicus
molecule keywords 5'-AMP-activated protein kinase catalytic subunit alpha-1
total genus 21
structure length 92
sequence length 99
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 4eakA01
2QRCA 2ZFDB 2QREA 2Y8QA 2V92A 2QR1A 3TDHA 4EALA 3OSEA 2QLVA 4EAGA 1V5SA 4EAIA 4EAKA 3TE5A 4CFFA 1UL7A 2V9JA 2OOXA 4EAJA 2EHBD 3T4NA 2V8QA 2Y8LA 2OOYA 2QRDA 2YA3A
chains in the Genus database with same CATH superfamily
1YTBA 1B9KA 2F7LA 2HZSA 3OH6A 1NVPA 3CW7A 4EJZA 2JHJA 2NVMA 4HJHA 4MRQA 1QNAA 1VOLB 3H1ZA 5IYBP 5BMNA 2G30A 3OSMA 1N3CA 1M3HA 3CVTA 2Z8UA 3NA5A 1QN9A 1QN5A 1KY7A 4EAIA 1C9BB 3N89A 1WJWA 3OGDA 3TE5A 2PWWA 1LWVA 1KFQA 4CFFA 1P5GX 1EUVA 1LXTA 2D0AA 3BKQX 3PDKA 5F9CA 3D4VA 1YTFA 2NOBA 1QTPA 2DKAA 3I0XA 2FGTA 4QG5A 1KYDA 3T4NA 3DPTA 3RPJA 3CWUA 1QN7A 2IV9A 1P5DX 1YQLA 2OOYA 1UT4A 2D0CA 3EIKA 2YA3A 1KYUA 3KRMA 5JMVD 1QNEA 1J3MA 2ZFDB 4DULA 1TBPA 1HU0A 2HKPA 1QNBA 3CWTA 2QR1A 2JPIA 3RSMA 1VTLE 3ULXA 4BJUA 2QLVA 2HL8A 2FKMX 1PCZA 2HL9A 4Q11A 4EAGA 3VN5A 1QN6A 1V5SA 4D7RA 1JFIC 3HS9A 1QTSA 2YH5A 3D7QA 2Z0FA 2H5AX 2XHIA 2LAEA 1PZDA 1D3UA 2NLVA 4EAJA 5IYCP 3I0WA 3C04A 2EHBD 2DKDA 3CWAA 2NOIA 4WX8A 3CWSA 4B0AA 1WQAA 2FKFA 3OLPA 1TBAB 4WZSD 2JHNA 2QRDA 4I8OA 4TPSA 1KO9A 2QREA 1N39A 2V92A 3OSTA 2I5WA 1M5Q1 4RODB 1KFIA 3OH9A 3F10A 3OSEA 2MJ7A 3I3WA 1LWYA 3CVSA 1QN3A 1VKLA 1PCJX 1KY6A 3IH7A 1VTOA 2R5XA 3DPUA 2NOLA 2NOHA 1TGHA 1NH2A 1T6AA 4EJYA 5EPCA 5JN5A 4PY5A 1QN8A 1DIZA 3OCIA 4ROEB 3PMGA 3ENOC 4D7QA 3F0ZA 1KYFA 3ENCA 2HZMA 1MP9A 2VJ0A 2QRCA 1K35A 1C4GA 3OC3C 1N3AA 1XSZA 2Y8QA 3ASMA 1PVSA 1C47A 2JOIA 2NWVA 4ROCB 1LWWA 3TDHA 1FN7A 5KL0A 4EALA 1R4XA 1NGMA 1MPGA 2H4LX 3SNSA 3KTUA 3UW2A 4WXAA 1E42A 4C7PA 1RM1A 1EBMA 2NOFA 1M3QA 1Q9UA 1TUOA 2IV8A 4EAKA 1VOKA 1AISA 1UL7A 2V9JA 1JDYA 2OOXA 1YQKA 2FUVA 2D0BA 1QN4A 2DKCA 3EAYA 5BMPA 3HS8A 1UT7A 1YQMA 1QNCA 2MZ8A 2V8QA 1CDWA 2NOZA 1W80A 2Y8LA 5HSHA 4IL8A 5AN4A 1YQRA 1K2YX 2NOEA 2O3OA 5IYDP 1PCMX
chains in the Genus database with same CATH topology
2QRCA 2ZFDB 2QREA 2Y8QA 2V92A 2QR1A 3TDHA 4EALA 3OSEA 2QLVA 4EAGA 1V5SA 4EAIA 4EAKA 3TE5A 4CFFA 1UL7A 2V9JA 2OOXA 4EAJA 2EHBD 3T4NA 2V8QA 2Y8LA 2OOYA 2QRDA 2YA3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QRC A;  2ZFD B;  2QRE A;  2Y8Q A;  2V92 A;  2QR1 A;  3TDH A;  4EAL A;  3OSE A;  2QLV A;  4EAG A;  1V5S A;  4EAI A;  4EAK A;  3TE5 A;  4CFF A;  1UL7 A;  2V9J A;  2OOX A;  4EAJ A;  2EHB D;  3T4N A;  2V8Q A;  2Y8L A;  2OOY A;  2QRD A;  2YA3 A; 
#chains in the Genus database with same CATH topology
 1YTB A;  1B9K A;  2F7L A;  2HZS A;  3OH6 A;  1NVP A;  3CW7 A;  4EJZ A;  2JHJ A;  2NVM A;  4HJH A;  4MRQ A;  1QNA A;  1VOL B;  3H1Z A;  5IYB P;  5BMN A;  2G30 A;  3OSM A;  1N3C A;  1M3H A;  3CVT A;  2Z8U A;  3NA5 A;  1QN9 A;  1QN5 A;  1KY7 A;  4EAI A;  1C9B B;  3N89 A;  1WJW A;  3OGD A;  3TE5 A;  2PWW A;  1LWV A;  1KFQ A;  4CFF A;  1P5G X;  1EUV A;  1LXT A;  2D0A A;  3BKQ X;  3PDK A;  5F9C A;  3D4V A;  1YTF A;  2NOB A;  1QTP A;  2DKA A;  3I0X A;  2FGT A;  4QG5 A;  1KYD A;  3T4N A;  3DPT A;  3RPJ A;  3CWU A;  1QN7 A;  2IV9 A;  1P5D X;  1YQL A;  2OOY A;  1UT4 A;  2D0C A;  3EIK A;  2YA3 A;  1KYU A;  3KRM A;  5JMV D;  1QNE A;  1J3M A;  2ZFD B;  4DUL A;  1TBP A;  1HU0 A;  2HKP A;  1QNB A;  3CWT A;  2QR1 A;  2JPI A;  3RSM A;  1VTL E;  3ULX A;  4BJU A;  2QLV A;  2HL8 A;  2FKM X;  1PCZ A;  2HL9 A;  4Q11 A;  4EAG A;  3VN5 A;  1QN6 A;  1V5S A;  4D7R A;  1JFI C;  3HS9 A;  1QTS A;  2YH5 A;  3D7Q A;  2Z0F A;  2H5A X;  2XHI A;  2LAE A;  1PZD A;  1D3U A;  2NLV A;  4EAJ A;  5IYC P;  3I0W A;  3C04 A;  2EHB D;  2DKD A;  3CWA A;  2NOI A;  4WX8 A;  3CWS A;  4B0A A;  1WQA A;  2FKF A;  3OLP A;  1TBA B;  4WZS D;  2JHN A;  2QRD A;  4I8O A;  4TPS A;  1KO9 A;  2QRE A;  1N39 A;  2V92 A;  3OST A;  2I5W A;  1M5Q 1;  4ROD B;  1KFI A;  3OH9 A;  3F10 A;  3OSE A;  2MJ7 A;  3I3W A;  1LWY A;  3CVS A;  1QN3 A;  1VKL A;  1PCJ X;  1KY6 A;  3IH7 A;  1VTO A;  2R5X A;  3DPU A;  2NOL A;  2NOH A;  1TGH A;  1NH2 A;  1T6A A;  4EJY A;  5EPC A;  5JN5 A;  4PY5 A;  1QN8 A;  1DIZ A;  3OCI A;  4ROE B;  3PMG A;  3ENO C;  4D7Q A;  3F0Z A;  1KYF A;  3ENC A;  2HZM A;  1MP9 A;  2VJ0 A;  2QRC A;  1K35 A;  1C4G A;  3OC3 C;  1N3A A;  1XSZ A;  2Y8Q A;  3ASM A;  1PVS A;  1C47 A;  2JOI A;  2NWV A;  4ROC B;  1LWW A;  3TDH A;  1FN7 A;  5KL0 A;  4EAL A;  1R4X A;  1NGM A;  1MPG A;  2H4L X;  3SNS A;  3KTU A;  3UW2 A;  4WXA A;  1E42 A;  4C7P A;  1RM1 A;  1EBM A;  2NOF A;  1M3Q A;  1Q9U A;  1TUO A;  2IV8 A;  4EAK A;  1VOK A;  1AIS A;  1UL7 A;  2V9J A;  1JDY A;  2OOX A;  1YQK A;  2FUV A;  2D0B A;  1QN4 A;  2DKC A;  3EAY A;  5BMP A;  3HS8 A;  1UT7 A;  1YQM A;  1QNC A;  2MZ8 A;  2V8Q A;  1CDW A;  2NOZ A;  1W80 A;  2Y8L A;  5HSH A;  4IL8 A;  5AN4 A;  1YQR A;  1K2Y X;  2NOE A;  2O3O A;  5IYD P;  1PCM X; 
#chains in the Genus database with same CATH homology
 2QRC A;  2ZFD B;  2QRE A;  2Y8Q A;  2V92 A;  2QR1 A;  3TDH A;  4EAL A;  3OSE A;  2QLV A;  4EAG A;  1V5S A;  4EAI A;  4EAK A;  3TE5 A;  4CFF A;  1UL7 A;  2V9J A;  2OOX A;  4EAJ A;  2EHB D;  3T4N A;  2V8Q A;  2Y8L A;  2OOY A;  2QRD A;  2YA3 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...