2Y8LA

Structure of the regulatory fragment of mammalian ampk in complex with two adp
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
158
structure length
104
Chain Sequence
SMAWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEVAPRPGSHTIEFFEMCANLIKNSCTVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of Mammalian Ampk and its Regulation by Adp
pubmed doi rcsb
molecule tags Transferase
source organism Rattus norvegicus
molecule keywords 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1
total genus 25
structure length 104
sequence length 158
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2011-02-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 2y8lA01
2V8QA 1UL7A 4EAKA 2Y8QA 2Y8LA 2OOXA 4CFFA 2QRDA 4EAJA 3TE5A 3OSEA 2V92A 2QLVA 2OOYA 2EHBD 2QR1A 2QREA 2QRCA 2V9JA 2ZFDB 2YA3A 3TDHA 4EAIA 4EAGA 4EALA 3T4NA 1V5SA
chains in the Genus database with same CATH superfamily
2FUVA 1XSZA 5AN4A 1UL7A 2MJ7A 2NOIA 1E42A 4Q11A 4EAKA 3OCIA 3I0XA 5JN5A 1QN5A 4EJYA 1K35A 3ENOC 2OOXA 5EPCA 1QN3A 1C47A 1MP9A 2FGTA 1YTFA 4B0AA 5F9CA 3CVTA 1QTPA 2Z8UA 1QN8A 2D0BA 1KO9A 1D3UA 4DULA 1WQAA 2MZ8A 3DPUA 3SNSA 5JMVD 2NOZA 1QTSA 2V9JA 3KRMA 1YQKA 1PCJX 3OGDA 4ROCB 1C9BB 2I5WA 2NOBA 3F10A 1M3HA 3CVSA 2IV8A 3EAYA 3T4NA 1T6AA 2F7LA 2G30A 2JHNA 1PCZA 1V5SA 5KL0A 1TUOA 3RSMA 1CDWA 3CW7A 2R5XA 3I3WA 4BJUA 2D0AA 2HL8A 3HS9A 3C04A 3EIKA 1N39A 1MPGA 1RM1A 3OH6A 1VTOA 1KFIA 3IH7A 1C4GA 3BKQX 5BMNA 2FKMX 3D4VA 1AISA 3F0ZA 3OLPA 1W80A 1R4XA 2QR1A 3DPTA 5HSHA 1KFQA 2QRCA 2DKAA 2IV9A 3OC3C 4ROEB 3CWUA 3ASMA 1LWVA 5BMPA 2NLVA 2D0CA 4EAGA 4EJZA 1NH2A 2HL9A 1M5Q1 2XHIA 2HKPA 2H5AX 2LAEA 3CWSA 2O3OA 1M3QA 1NGMA 2JHJA 1UT4A 1YQLA 2Z0FA 1KYUA 2Y8QA 1QNAA 1KYDA 1KY6A 4QG5A 1QNCA 1PZDA 1PVSA 4CFFA 3H1ZA 1EBMA 2VJ0A 4EAJA 2JPIA 3TE5A 4RODB 3OSEA 2V92A 1QN7A 3UW2A 1TBPA 1YQRA 1QNEA 1YTBA 2NOEA 2EHBD 2FKFA 1P5GX 3OH9A 2QREA 1HU0A 1K2YX 1WJWA 1EUVA 3VN5A 5IYDP 2DKCA 2H4LX 3NA5A 1VTLE 3ULXA 2ZFDB 2YA3A 2NOLA 4EALA 3KTUA 1YQMA 1KY7A 5IYBP 1QN6A 1TGHA 1Q9UA 2YH5A 4IL8A 2PWWA 4WZSD 2NOFA 1KYFA 3OSTA 2NVMA 1JDYA 2V8QA 3PMGA 5IYCP 2NWVA 1JFIC 4TPSA 4PY5A 2JOIA 2Y8LA 1VOLB 3CWTA 3I0WA 1N3AA 2NOHA 4WX8A 1P5DX 4WXAA 1J3MA 1NVPA 1TBAB 2QRDA 4I8OA 3ENCA 1LXTA 2QLVA 3D7QA 2OOYA 4HJHA 1N3CA 1QN4A 1PCMX 1VKLA 4D7QA 1LWYA 3OSMA 1LWWA 2HZSA 1VOKA 3HS8A 4D7RA 3TDHA 1UT7A 1QNBA 4EAIA 1B9KA 2HZMA 3N89A 3RPJA 1FN7A 2DKDA 3CWAA 3PDKA 4MRQA 4C7PA 1DIZA 1QN9A
chains in the Genus database with same CATH topology
2V8QA 1UL7A 4EAKA 2Y8QA 2Y8LA 2OOXA 4CFFA 2QRDA 4EAJA 3TE5A 3OSEA 2V92A 2QLVA 2OOYA 2EHBD 2QR1A 2QREA 2QRCA 2V9JA 2ZFDB 2YA3A 3TDHA 4EAIA 4EAGA 4EALA 3T4NA 1V5SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V8Q A;  1UL7 A;  4EAK A;  2Y8Q A;  2Y8L A;  2OOX A;  4CFF A;  2QRD A;  4EAJ A;  3TE5 A;  3OSE A;  2V92 A;  2QLV A;  2OOY A;  2EHB D;  2QR1 A;  2QRE A;  2QRC A;  2V9J A;  2ZFD B;  2YA3 A;  3TDH A;  4EAI A;  4EAG A;  4EAL A;  3T4N A;  1V5S A; 
#chains in the Genus database with same CATH topology
 2FUV A;  1XSZ A;  5AN4 A;  1UL7 A;  2MJ7 A;  2NOI A;  1E42 A;  4Q11 A;  4EAK A;  3OCI A;  3I0X A;  5JN5 A;  1QN5 A;  4EJY A;  1K35 A;  3ENO C;  2OOX A;  5EPC A;  1QN3 A;  1C47 A;  1MP9 A;  2FGT A;  1YTF A;  4B0A A;  5F9C A;  3CVT A;  1QTP A;  2Z8U A;  1QN8 A;  2D0B A;  1KO9 A;  1D3U A;  4DUL A;  1WQA A;  2MZ8 A;  3DPU A;  3SNS A;  5JMV D;  2NOZ A;  1QTS A;  2V9J A;  3KRM A;  1YQK A;  1PCJ X;  3OGD A;  4ROC B;  1C9B B;  2I5W A;  2NOB A;  3F10 A;  1M3H A;  3CVS A;  2IV8 A;  3EAY A;  3T4N A;  1T6A A;  2F7L A;  2G30 A;  2JHN A;  1PCZ A;  1V5S A;  5KL0 A;  1TUO A;  3RSM A;  1CDW A;  3CW7 A;  2R5X A;  3I3W A;  4BJU A;  2D0A A;  2HL8 A;  3HS9 A;  3C04 A;  3EIK A;  1N39 A;  1MPG A;  1RM1 A;  3OH6 A;  1VTO A;  1KFI A;  3IH7 A;  1C4G A;  3BKQ X;  5BMN A;  2FKM X;  3D4V A;  1AIS A;  3F0Z A;  3OLP A;  1W80 A;  1R4X A;  2QR1 A;  3DPT A;  5HSH A;  1KFQ A;  2QRC A;  2DKA A;  2IV9 A;  3OC3 C;  4ROE B;  3CWU A;  3ASM A;  1LWV A;  5BMP A;  2NLV A;  2D0C A;  4EAG A;  4EJZ A;  1NH2 A;  2HL9 A;  1M5Q 1;  2XHI A;  2HKP A;  2H5A X;  2LAE A;  3CWS A;  2O3O A;  1M3Q A;  1NGM A;  2JHJ A;  1UT4 A;  1YQL A;  2Z0F A;  1KYU A;  2Y8Q A;  1QNA A;  1KYD A;  1KY6 A;  4QG5 A;  1QNC A;  1PZD A;  1PVS A;  4CFF A;  3H1Z A;  1EBM A;  2VJ0 A;  4EAJ A;  2JPI A;  3TE5 A;  4ROD B;  3OSE A;  2V92 A;  1QN7 A;  3UW2 A;  1TBP A;  1YQR A;  1QNE A;  1YTB A;  2NOE A;  2EHB D;  2FKF A;  1P5G X;  3OH9 A;  2QRE A;  1HU0 A;  1K2Y X;  1WJW A;  1EUV A;  3VN5 A;  5IYD P;  2DKC A;  2H4L X;  3NA5 A;  1VTL E;  3ULX A;  2ZFD B;  2YA3 A;  2NOL A;  4EAL A;  3KTU A;  1YQM A;  1KY7 A;  5IYB P;  1QN6 A;  1TGH A;  1Q9U A;  2YH5 A;  4IL8 A;  2PWW A;  4WZS D;  2NOF A;  1KYF A;  3OST A;  2NVM A;  1JDY A;  2V8Q A;  3PMG A;  5IYC P;  2NWV A;  1JFI C;  4TPS A;  4PY5 A;  2JOI A;  2Y8L A;  1VOL B;  3CWT A;  3I0W A;  1N3A A;  2NOH A;  4WX8 A;  1P5D X;  4WXA A;  1J3M A;  1NVP A;  1TBA B;  2QRD A;  4I8O A;  3ENC A;  1LXT A;  2QLV A;  3D7Q A;  2OOY A;  4HJH A;  1N3C A;  1QN4 A;  1PCM X;  1VKL A;  4D7Q A;  1LWY A;  3OSM A;  1LWW A;  2HZS A;  1VOK A;  3HS8 A;  4D7R A;  3TDH A;  1UT7 A;  1QNB A;  4EAI A;  1B9K A;  2HZM A;  3N89 A;  3RPJ A;  1FN7 A;  2DKD A;  3CWA A;  3PDK A;  4MRQ A;  4C7P A;  1DIZ A;  1QN9 A; 
#chains in the Genus database with same CATH homology
 2V8Q A;  1UL7 A;  4EAK A;  2Y8Q A;  2Y8L A;  2OOX A;  4CFF A;  2QRD A;  4EAJ A;  3TE5 A;  3OSE A;  2V92 A;  2QLV A;  2OOY A;  2EHB D;  2QR1 A;  2QRE A;  2QRC A;  2V9J A;  2ZFD B;  2YA3 A;  3TDH A;  4EAI A;  4EAG A;  4EAL A;  3T4N A;  1V5S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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