2QREA

Crystal structure of the adenylate sensor from amp-activated protein kinase in complex with 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranotide (zmp)
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
126
structure length
109
Chain Sequence
KWHFGVRCRGDAPEILLAVYRALQRAGAQFTVPKPVNSDMYTIKSRWEIPHCKREGKNTYAYIELQLYEVMPGCFMLDVKSNGYKDIYSKSSFPFLDLCAMLVCKLFSA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Insight into AMPK Regulation: ADP Comes into Play.
pubmed doi rcsb
molecule tags Transferase
source organism Schizosaccharomyces pombe
molecule keywords SNF1-like protein kinase ssp2
total genus 29
structure length 109
sequence length 126
chains with identical sequence C
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2007-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF16579 AdenylateSensor Adenylate sensor of SNF1-like protein kinase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 2qreA00
2ZFDB 2EHBD 2Y8LA 1V5SA 2V9JA 4EALA 4EAKA 2QR1A 3OSEA 2QRCA 2V8QA 4EAJA 2OOYA 2QRDA 2Y8QA 2QREA 2QLVA 2V92A 4CFFA 3T4NA 4EAGA 4EAIA 1UL7A 3TE5A 2YA3A 3TDHA 2OOXA
chains in the Genus database with same CATH superfamily
2R5XA 3CWUA 2NOHA 1KFQA 3OLPA 5AN4A 3CWTA 2V9JA 4EAKA 2QR1A 1MPGA 1VTLE 1YTBA 3RPJA 3OSEA 2QRCA 5BMPA 1VOKA 1P5DX 1QNAA 3ENCA 1EBMA 3DPUA 3OC3C 1YQLA 1HU0A 2FKMX 1KFIA 2Y8QA 3ULXA 2NLVA 1D3UA 3RSMA 1N39A 2Z8UA 2DKAA 1KYUA 3BKQX 1M3HA 4EJZA 3TE5A 2HZMA 5HSHA 1QNEA 1YTFA 1C9BB 1MP9A 4WZSD 4HJHA 2H5AX 4TPSA 4ROCB 3EIKA 1M3QA 1JDYA 2ZFDB 3CWAA 4WX8A 1V5SA 1W80A 1TGHA 1QN9A 1UT4A 1QTSA 2MZ8A 3EAYA 1E42A 3C04A 3OH9A 3CW7A 1UT7A 2Z0FA 2NOFA 4EALA 5F9CA 1QTPA 3F10A 5IYBP 1Q9UA 2V8QA 5KL0A 1PVSA 1VOLB 1QN4A 2QRDA 5JMVD 1J3MA 2MJ7A 1M5Q1 1FN7A 1B9KA 1K35A 2HZSA 3ASMA 2NOLA 2NOZA 3OCIA 1VTOA 3SNSA 1NGMA 2HKPA 2D0CA 4C7PA 1UL7A 4MRQA 4PY5A 3VN5A 3I0WA 2YA3A 4QG5A 4I8OA 1KY6A 1EUVA 4WXAA 1WQAA 1LWVA 2FUVA 3CVSA 1NH2A 1VKLA 2EHBD 2FKFA 1T6AA 2NVMA 2PWWA 5JN5A 3CWSA 1TUOA 2G30A 3KRMA 4ROEB 1PCZA 1CDWA 1P5GX 2NOBA 3DPTA 2IV9A 3I0XA 5EPCA 3PMGA 1AISA 1JFIC 3IH7A 2D0BA 3N89A 1TBPA 3HS8A 2QREA 2V92A 1LWYA 3NA5A 4EAGA 1KY7A 4D7RA 1C47A 2FGTA 2H4LX 2F7LA 3HS9A 1N3AA 1QN3A 3TDHA 2NOEA 2NOIA 1K2YX 4B0AA 2O3OA 3F0ZA 2HL9A 3H1ZA 4D7QA 2LAEA 2XHIA 1C4GA 2YH5A 2Y8LA 2DKCA 3CVTA 1QN6A 2DKDA 3PDKA 3D7QA 2D0AA 3OGDA 1DIZA 1LXTA 3ENOC 4IL8A 1PCJX 2VJ0A 1TBAB 1KYFA 4BJUA 1R4XA 1QNCA 3UW2A 1XSZA 4EAJA 1KO9A 1KYDA 3OH6A 2OOYA 1PCMX 3I3WA 5IYCP 1QN7A 5IYDP 5BMNA 3OSMA 4DULA 1QN5A 4Q11A 2QLVA 1QN8A 3OSTA 4CFFA 2HL8A 3T4NA 4EJYA 4EAIA 1YQMA 2I5WA 1N3CA 1YQRA 1WJWA 1RM1A 1PZDA 2JPIA 2NWVA 3KTUA 2JHNA 2JHJA 3D4VA 2OOXA 1YQKA 1NVPA 1LWWA 2IV8A 4RODB 2JOIA 1QNBA
chains in the Genus database with same CATH topology
2ZFDB 2EHBD 2Y8LA 1V5SA 2V9JA 4EALA 4EAKA 2QR1A 3OSEA 2QRCA 2V8QA 4EAJA 2OOYA 2QRDA 2Y8QA 2QREA 2QLVA 2V92A 4CFFA 3T4NA 4EAGA 4EAIA 1UL7A 3TE5A 2YA3A 3TDHA 2OOXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZFD B;  2EHB D;  2Y8L A;  1V5S A;  2V9J A;  4EAL A;  4EAK A;  2QR1 A;  3OSE A;  2QRC A;  2V8Q A;  4EAJ A;  2OOY A;  2QRD A;  2Y8Q A;  2QRE A;  2QLV A;  2V92 A;  4CFF A;  3T4N A;  4EAG A;  4EAI A;  1UL7 A;  3TE5 A;  2YA3 A;  3TDH A;  2OOX A; 
#chains in the Genus database with same CATH topology
 2R5X A;  3CWU A;  2NOH A;  1KFQ A;  3OLP A;  5AN4 A;  3CWT A;  2V9J A;  4EAK A;  2QR1 A;  1MPG A;  1VTL E;  1YTB A;  3RPJ A;  3OSE A;  2QRC A;  5BMP A;  1VOK A;  1P5D X;  1QNA A;  3ENC A;  1EBM A;  3DPU A;  3OC3 C;  1YQL A;  1HU0 A;  2FKM X;  1KFI A;  2Y8Q A;  3ULX A;  2NLV A;  1D3U A;  3RSM A;  1N39 A;  2Z8U A;  2DKA A;  1KYU A;  3BKQ X;  1M3H A;  4EJZ A;  3TE5 A;  2HZM A;  5HSH A;  1QNE A;  1YTF A;  1C9B B;  1MP9 A;  4WZS D;  4HJH A;  2H5A X;  4TPS A;  4ROC B;  3EIK A;  1M3Q A;  1JDY A;  2ZFD B;  3CWA A;  4WX8 A;  1V5S A;  1W80 A;  1TGH A;  1QN9 A;  1UT4 A;  1QTS A;  2MZ8 A;  3EAY A;  1E42 A;  3C04 A;  3OH9 A;  3CW7 A;  1UT7 A;  2Z0F A;  2NOF A;  4EAL A;  5F9C A;  1QTP A;  3F10 A;  5IYB P;  1Q9U A;  2V8Q A;  5KL0 A;  1PVS A;  1VOL B;  1QN4 A;  2QRD A;  5JMV D;  1J3M A;  2MJ7 A;  1M5Q 1;  1FN7 A;  1B9K A;  1K35 A;  2HZS A;  3ASM A;  2NOL A;  2NOZ A;  3OCI A;  1VTO A;  3SNS A;  1NGM A;  2HKP A;  2D0C A;  4C7P A;  1UL7 A;  4MRQ A;  4PY5 A;  3VN5 A;  3I0W A;  2YA3 A;  4QG5 A;  4I8O A;  1KY6 A;  1EUV A;  4WXA A;  1WQA A;  1LWV A;  2FUV A;  3CVS A;  1NH2 A;  1VKL A;  2EHB D;  2FKF A;  1T6A A;  2NVM A;  2PWW A;  5JN5 A;  3CWS A;  1TUO A;  2G30 A;  3KRM A;  4ROE B;  1PCZ A;  1CDW A;  1P5G X;  2NOB A;  3DPT A;  2IV9 A;  3I0X A;  5EPC A;  3PMG A;  1AIS A;  1JFI C;  3IH7 A;  2D0B A;  3N89 A;  1TBP A;  3HS8 A;  2QRE A;  2V92 A;  1LWY A;  3NA5 A;  4EAG A;  1KY7 A;  4D7R A;  1C47 A;  2FGT A;  2H4L X;  2F7L A;  3HS9 A;  1N3A A;  1QN3 A;  3TDH A;  2NOE A;  2NOI A;  1K2Y X;  4B0A A;  2O3O A;  3F0Z A;  2HL9 A;  3H1Z A;  4D7Q A;  2LAE A;  2XHI A;  1C4G A;  2YH5 A;  2Y8L A;  2DKC A;  3CVT A;  1QN6 A;  2DKD A;  3PDK A;  3D7Q A;  2D0A A;  3OGD A;  1DIZ A;  1LXT A;  3ENO C;  4IL8 A;  1PCJ X;  2VJ0 A;  1TBA B;  1KYF A;  4BJU A;  1R4X A;  1QNC A;  3UW2 A;  1XSZ A;  4EAJ A;  1KO9 A;  1KYD A;  3OH6 A;  2OOY A;  1PCM X;  3I3W A;  5IYC P;  1QN7 A;  5IYD P;  5BMN A;  3OSM A;  4DUL A;  1QN5 A;  4Q11 A;  2QLV A;  1QN8 A;  3OST A;  4CFF A;  2HL8 A;  3T4N A;  4EJY A;  4EAI A;  1YQM A;  2I5W A;  1N3C A;  1YQR A;  1WJW A;  1RM1 A;  1PZD A;  2JPI A;  2NWV A;  3KTU A;  2JHN A;  2JHJ A;  3D4V A;  2OOX A;  1YQK A;  1NVP A;  1LWW A;  2IV8 A;  4ROD B;  2JOI A;  1QNB A; 
#chains in the Genus database with same CATH homology
 2ZFD B;  2EHB D;  2Y8L A;  1V5S A;  2V9J A;  4EAL A;  4EAK A;  2QR1 A;  3OSE A;  2QRC A;  2V8Q A;  4EAJ A;  2OOY A;  2QRD A;  2Y8Q A;  2QRE A;  2QLV A;  2V92 A;  4CFF A;  3T4N A;  4EAG A;  4EAI A;  1UL7 A;  3TE5 A;  2YA3 A;  3TDH A;  2OOX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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