3OSEA

Structure of the kinase associated domain 1 (ka1) from mark1 kinase
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
100
structure length
100
Chain Sequence
KPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids.
pubmed doi rcsb
molecule tags Lipid binding protein
source organism Homo sapiens
molecule keywords Serine/threonine-protein kinase MARK1
total genus 27
structure length 100
sequence length 100
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2010-09-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02149 KA1 Kinase associated domain 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 3oseA00
4EAJA 2QLVA 2QRCA 4EAKA 2ZFDB 2QREA 4CFFA 2V92A 3OSEA 2OOYA 1UL7A 2EHBD 2Y8QA 2QR1A 1V5SA 2YA3A 2QRDA 3TDHA 2OOXA 4EAGA 2V9JA 3TE5A 4EALA 3T4NA 2V8QA 4EAIA 2Y8LA
chains in the Genus database with same CATH superfamily
1DIZA 1QTPA 3HS8A 2HZMA 1C4GA 3PMGA 3CVSA 5KL0A 1T6AA 4ROEB 1QN4A 4CFFA 2V92A 4MRQA 4D7RA 2H4LX 2NOLA 2EHBD 3KRMA 1Q9UA 2JPIA 2MZ8A 4D7QA 1MPGA 3KTUA 3C04A 3BKQX 2NOHA 1V5SA 1M3HA 1J3MA 3OCIA 5AN4A 3D4VA 2NOBA 3CVTA 1KYUA 3TDHA 4EAGA 3HS9A 5IYDP 1TUOA 1NH2A 4Q11A 2HZSA 2D0AA 1RM1A 1K35A 1YQLA 4PY5A 2Y8LA 3IH7A 2NOZA 1KYFA 1UT4A 4EAJA 2NVMA 1AISA 1VOLB 2NWVA 3RPJA 2ZFDB 2D0CA 5F9CA 3CWSA 2HL8A 2YH5A 1VOKA 1M3QA 1KYDA 1C9BB 3CW7A 1M5Q1 1UL7A 1D3UA 1MP9A 1XSZA 1QNCA 2H5AX 2Y8QA 3EAYA 3H1ZA 1NVPA 1QN9A 1QN5A 2NOFA 2G30A 1FN7A 4I8OA 5BMNA 4ROCB 2NLVA 1VTLE 2OOXA 5EPCA 4WXAA 2V9JA 2O3OA 2PWWA 3TE5A 1KY6A 4EALA 1KFQA 2JHJA 1YQKA 2HL9A 1W80A 1HU0A 2D0BA 2Z0FA 4B0AA 1QN7A 4QG5A 2QLVA 3D7QA 5IYBP 3ULXA 1PCJX 2QRCA 1LWYA 1E42A 2FUVA 3OGDA 1CDWA 2JHNA 2NOEA 1QNEA 3DPTA 3NA5A 1WQAA 4EJZA 1EUVA 3OSEA 3CWAA 1TBAB 3CWUA 1QN3A 5JMVD 1YQMA 1K2YX 5BMPA 5JN5A 3OC3C 4RODB 2LAEA 2R5XA 4WZSD 1LXTA 1VKLA 2QRDA 1KFIA 3ENCA 4HJHA 1LWVA 1YQRA 1YTFA 1N3AA 1JDYA 3I3WA 1UT7A 2MJ7A 3PDKA 4C7PA 5IYCP 1LWWA 2Z8UA 1TGHA 2NOIA 4TPSA 3EIKA 1P5GX 2JOIA 3T4NA 4EAIA 2IV9A 1C47A 3CWTA 1PCZA 3I0XA 1PVSA 4WX8A 3ASMA 4IL8A 3N89A 1QNAA 2I5WA 4EJYA 2IV8A 3ENOC 4EAKA 1KY7A 1R4XA 2FGTA 2XHIA 1VTOA 1YTBA 3OSTA 1NGMA 1B9KA 1KO9A 1P5DX 2FKMX 2QREA 3DPUA 3F0ZA 1QN8A 2F7LA 1WJWA 1JFIC 3F10A 4DULA 2OOYA 1QN6A 3OLPA 2VJ0A 1N39A 1QTSA 2DKAA 3RSMA 3OH9A 3SNSA 1N3CA 1TBPA 2QR1A 3UW2A 4BJUA 1PCMX 2YA3A 3OSMA 3I0WA 2DKCA 3VN5A 2DKDA 2HKPA 5HSHA 2FKFA 3OH6A 1QNBA 1PZDA 2V8QA 1EBMA
chains in the Genus database with same CATH topology
4EAJA 2QLVA 2QRCA 4EAKA 2ZFDB 2QREA 4CFFA 2V92A 3OSEA 2OOYA 1UL7A 2EHBD 2Y8QA 2QR1A 1V5SA 2YA3A 2QRDA 3TDHA 2OOXA 4EAGA 2V9JA 3TE5A 4EALA 3T4NA 2V8QA 4EAIA 2Y8LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EAJ A;  2QLV A;  2QRC A;  4EAK A;  2ZFD B;  2QRE A;  4CFF A;  2V92 A;  3OSE A;  2OOY A;  1UL7 A;  2EHB D;  2Y8Q A;  2QR1 A;  1V5S A;  2YA3 A;  2QRD A;  3TDH A;  2OOX A;  4EAG A;  2V9J A;  3TE5 A;  4EAL A;  3T4N A;  2V8Q A;  4EAI A;  2Y8L A; 
#chains in the Genus database with same CATH topology
 1DIZ A;  1QTP A;  3HS8 A;  2HZM A;  1C4G A;  3PMG A;  3CVS A;  5KL0 A;  1T6A A;  4ROE B;  1QN4 A;  4CFF A;  2V92 A;  4MRQ A;  4D7R A;  2H4L X;  2NOL A;  2EHB D;  3KRM A;  1Q9U A;  2JPI A;  2MZ8 A;  4D7Q A;  1MPG A;  3KTU A;  3C04 A;  3BKQ X;  2NOH A;  1V5S A;  1M3H A;  1J3M A;  3OCI A;  5AN4 A;  3D4V A;  2NOB A;  3CVT A;  1KYU A;  3TDH A;  4EAG A;  3HS9 A;  5IYD P;  1TUO A;  1NH2 A;  4Q11 A;  2HZS A;  2D0A A;  1RM1 A;  1K35 A;  1YQL A;  4PY5 A;  2Y8L A;  3IH7 A;  2NOZ A;  1KYF A;  1UT4 A;  4EAJ A;  2NVM A;  1AIS A;  1VOL B;  2NWV A;  3RPJ A;  2ZFD B;  2D0C A;  5F9C A;  3CWS A;  2HL8 A;  2YH5 A;  1VOK A;  1M3Q A;  1KYD A;  1C9B B;  3CW7 A;  1M5Q 1;  1UL7 A;  1D3U A;  1MP9 A;  1XSZ A;  1QNC A;  2H5A X;  2Y8Q A;  3EAY A;  3H1Z A;  1NVP A;  1QN9 A;  1QN5 A;  2NOF A;  2G30 A;  1FN7 A;  4I8O A;  5BMN A;  4ROC B;  2NLV A;  1VTL E;  2OOX A;  5EPC A;  4WXA A;  2V9J A;  2O3O A;  2PWW A;  3TE5 A;  1KY6 A;  4EAL A;  1KFQ A;  2JHJ A;  1YQK A;  2HL9 A;  1W80 A;  1HU0 A;  2D0B A;  2Z0F A;  4B0A A;  1QN7 A;  4QG5 A;  2QLV A;  3D7Q A;  5IYB P;  3ULX A;  1PCJ X;  2QRC A;  1LWY A;  1E42 A;  2FUV A;  3OGD A;  1CDW A;  2JHN A;  2NOE A;  1QNE A;  3DPT A;  3NA5 A;  1WQA A;  4EJZ A;  1EUV A;  3OSE A;  3CWA A;  1TBA B;  3CWU A;  1QN3 A;  5JMV D;  1YQM A;  1K2Y X;  5BMP A;  5JN5 A;  3OC3 C;  4ROD B;  2LAE A;  2R5X A;  4WZS D;  1LXT A;  1VKL A;  2QRD A;  1KFI A;  3ENC A;  4HJH A;  1LWV A;  1YQR A;  1YTF A;  1N3A A;  1JDY A;  3I3W A;  1UT7 A;  2MJ7 A;  3PDK A;  4C7P A;  5IYC P;  1LWW A;  2Z8U A;  1TGH A;  2NOI A;  4TPS A;  3EIK A;  1P5G X;  2JOI A;  3T4N A;  4EAI A;  2IV9 A;  1C47 A;  3CWT A;  1PCZ A;  3I0X A;  1PVS A;  4WX8 A;  3ASM A;  4IL8 A;  3N89 A;  1QNA A;  2I5W A;  4EJY A;  2IV8 A;  3ENO C;  4EAK A;  1KY7 A;  1R4X A;  2FGT A;  2XHI A;  1VTO A;  1YTB A;  3OST A;  1NGM A;  1B9K A;  1KO9 A;  1P5D X;  2FKM X;  2QRE A;  3DPU A;  3F0Z A;  1QN8 A;  2F7L A;  1WJW A;  1JFI C;  3F10 A;  4DUL A;  2OOY A;  1QN6 A;  3OLP A;  2VJ0 A;  1N39 A;  1QTS A;  2DKA A;  3RSM A;  3OH9 A;  3SNS A;  1N3C A;  1TBP A;  2QR1 A;  3UW2 A;  4BJU A;  1PCM X;  2YA3 A;  3OSM A;  3I0W A;  2DKC A;  3VN5 A;  2DKD A;  2HKP A;  5HSH A;  2FKF A;  3OH6 A;  1QNB A;  1PZD A;  2V8Q A;  1EBM A; 
#chains in the Genus database with same CATH homology
 4EAJ A;  2QLV A;  2QRC A;  4EAK A;  2ZFD B;  2QRE A;  4CFF A;  2V92 A;  3OSE A;  2OOY A;  1UL7 A;  2EHB D;  2Y8Q A;  2QR1 A;  1V5S A;  2YA3 A;  2QRD A;  3TDH A;  2OOX A;  4EAG A;  2V9J A;  3TE5 A;  4EAL A;  3T4N A;  2V8Q A;  4EAI A;  2Y8L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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