4EAGA

Co-crystal structure of an chimeric ampk core with atp
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
125
structure length
98
Chain Sequence
AKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTLQPTGHHTMEFFEMCAALIIQLAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
pubmed doi rcsb
molecule tags Transferase
source organism Drosophila melanogaster
molecule keywords EG:132E8.2 protein
total genus 21
structure length 98
sequence length 125
ec nomenclature ec 2.7.11.-:
pdb deposition date 2012-03-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF16579 AdenylateSensor Adenylate sensor of SNF1-like protein kinase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 4eagA01
4CFFA 2Y8LA 2YA3A 2Y8QA 2QRCA 3T4NA 4EAJA 3TDHA 2EHBD 4EAGA 3OSEA 1UL7A 2V92A 4EAKA 2QREA 2V8QA 2ZFDB 2OOXA 2QLVA 2QRDA 2OOYA 2QR1A 4EAIA 2V9JA 3TE5A 4EALA 1V5SA
chains in the Genus database with same CATH superfamily
3HS9A 1LWVA 3EAYA 3CVSA 1P5GX 2JPIA 3RSMA 2Y8LA 3CVTA 2YA3A 1M3HA 1QTPA 2D0BA 2FKMX 3I0WA 4D7RA 1PCZA 1QN8A 2NOZA 1EUVA 1KFQA 1QN6A 1WJWA 3OC3C 5JN5A 4C7PA 1LWWA 2NOBA 1Q9UA 1K35A 1R4XA 2I5WA 2OOXA 1M3QA 1TBAB 3UW2A 2NLVA 1FN7A 1QN5A 1N3CA 2MJ7A 5IYCP 1E42A 1KYFA 1KYDA 1LXTA 3F10A 5KL0A 4EAIA 1VTOA 4B0AA 1QN7A 1QTSA 1VOKA 1KYUA 3SNSA 1YQMA 4IL8A 1B9KA 1XSZA 3I3WA 2IV8A 1JFIC 2NOLA 2JHNA 3ULXA 1D3UA 2Y8QA 5IYDP 2HL9A 1VTLE 1HU0A 2QRCA 2O3OA 1YTFA 4TPSA 3CW7A 2FGTA 5F9CA 2LAEA 1QNBA 2V92A 3CWAA 4EJYA 2NVMA 2R5XA 2HZMA 4ROCB 1VOLB 1C47A 3DPUA 2V8QA 1NH2A 1QNEA 3OLPA 4DULA 3D7QA 2NWVA 1YQKA 1YQRA 2MZ8A 5JMVD 1TUOA 1WQAA 3OSMA 2DKDA 1N39A 4WX8A 2QR1A 3N89A 3PMGA 1P5DX 4EALA 4QG5A 2NOEA 1V5SA 1T6AA 1DIZA 4EJZA 1K2YX 5AN4A 4CFFA 2G30A 3OGDA 1MPGA 4PY5A 2NOIA 2H4LX 3D4VA 1PCJX 4MRQA 2IV9A 5BMNA 1EBMA 3T4NA 1UT7A 3CWSA 1MP9A 1TBPA 2EHBD 4I8OA 4EAGA 1C4GA 2F7LA 3NA5A 1UL7A 5IYBP 3F0ZA 2HZSA 1QNCA 2D0AA 2DKAA 3PDKA 2QREA 4RODB 3IH7A 3KRMA 2XHIA 1UT4A 1JDYA 2DKCA 5BMPA 1LWYA 3H1ZA 3CWTA 1QN9A 2HL8A 2QRDA 2Z0FA 3OSTA 1NGMA 1N3AA 2V9JA 3EIKA 3I0XA 1W80A 1TGHA 4WZSD 1KO9A 1KFIA 4D7QA 1PVSA 1RM1A 2NOFA 3OCIA 3C04A 3BKQX 2YH5A 1KY6A 3ENOC 2H5AX 3OH6A 2JOIA 3KTUA 3RPJA 3OH9A 4EAJA 3TDHA 4ROEB 2FUVA 3OSEA 1YQLA 1QN4A 2FKFA 1QNAA 3CWUA 3ASMA 5EPCA 1CDWA 1M5Q1 2VJ0A 3ENCA 1NVPA 1C9BB 2HKPA 4EAKA 3VN5A 2PWWA 5HSHA 1QN3A 1YTBA 1PZDA 2ZFDB 4WXAA 2QLVA 3HS8A 2Z8UA 1J3MA 3DPTA 2NOHA 1KY7A 2D0CA 2OOYA 4BJUA 3TE5A 1AISA 1PCMX 4HJHA 4Q11A 1VKLA 2JHJA
chains in the Genus database with same CATH topology
4CFFA 2Y8LA 2YA3A 2Y8QA 2QRCA 3T4NA 4EAJA 3TDHA 2EHBD 4EAGA 3OSEA 1UL7A 2V92A 4EAKA 2QREA 2V8QA 2ZFDB 2OOXA 2QLVA 2QRDA 2OOYA 2QR1A 4EAIA 2V9JA 3TE5A 4EALA 1V5SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CFF A;  2Y8L A;  2YA3 A;  2Y8Q A;  2QRC A;  3T4N A;  4EAJ A;  3TDH A;  2EHB D;  4EAG A;  3OSE A;  1UL7 A;  2V92 A;  4EAK A;  2QRE A;  2V8Q A;  2ZFD B;  2OOX A;  2QLV A;  2QRD A;  2OOY A;  2QR1 A;  4EAI A;  2V9J A;  3TE5 A;  4EAL A;  1V5S A; 
#chains in the Genus database with same CATH topology
 3HS9 A;  1LWV A;  3EAY A;  3CVS A;  1P5G X;  2JPI A;  3RSM A;  2Y8L A;  3CVT A;  2YA3 A;  1M3H A;  1QTP A;  2D0B A;  2FKM X;  3I0W A;  4D7R A;  1PCZ A;  1QN8 A;  2NOZ A;  1EUV A;  1KFQ A;  1QN6 A;  1WJW A;  3OC3 C;  5JN5 A;  4C7P A;  1LWW A;  2NOB A;  1Q9U A;  1K35 A;  1R4X A;  2I5W A;  2OOX A;  1M3Q A;  1TBA B;  3UW2 A;  2NLV A;  1FN7 A;  1QN5 A;  1N3C A;  2MJ7 A;  5IYC P;  1E42 A;  1KYF A;  1KYD A;  1LXT A;  3F10 A;  5KL0 A;  4EAI A;  1VTO A;  4B0A A;  1QN7 A;  1QTS A;  1VOK A;  1KYU A;  3SNS A;  1YQM A;  4IL8 A;  1B9K A;  1XSZ A;  3I3W A;  2IV8 A;  1JFI C;  2NOL A;  2JHN A;  3ULX A;  1D3U A;  2Y8Q A;  5IYD P;  2HL9 A;  1VTL E;  1HU0 A;  2QRC A;  2O3O A;  1YTF A;  4TPS A;  3CW7 A;  2FGT A;  5F9C A;  2LAE A;  1QNB A;  2V92 A;  3CWA A;  4EJY A;  2NVM A;  2R5X A;  2HZM A;  4ROC B;  1VOL B;  1C47 A;  3DPU A;  2V8Q A;  1NH2 A;  1QNE A;  3OLP A;  4DUL A;  3D7Q A;  2NWV A;  1YQK A;  1YQR A;  2MZ8 A;  5JMV D;  1TUO A;  1WQA A;  3OSM A;  2DKD A;  1N39 A;  4WX8 A;  2QR1 A;  3N89 A;  3PMG A;  1P5D X;  4EAL A;  4QG5 A;  2NOE A;  1V5S A;  1T6A A;  1DIZ A;  4EJZ A;  1K2Y X;  5AN4 A;  4CFF A;  2G30 A;  3OGD A;  1MPG A;  4PY5 A;  2NOI A;  2H4L X;  3D4V A;  1PCJ X;  4MRQ A;  2IV9 A;  5BMN A;  1EBM A;  3T4N A;  1UT7 A;  3CWS A;  1MP9 A;  1TBP A;  2EHB D;  4I8O A;  4EAG A;  1C4G A;  2F7L A;  3NA5 A;  1UL7 A;  5IYB P;  3F0Z A;  2HZS A;  1QNC A;  2D0A A;  2DKA A;  3PDK A;  2QRE A;  4ROD B;  3IH7 A;  3KRM A;  2XHI A;  1UT4 A;  1JDY A;  2DKC A;  5BMP A;  1LWY A;  3H1Z A;  3CWT A;  1QN9 A;  2HL8 A;  2QRD A;  2Z0F A;  3OST A;  1NGM A;  1N3A A;  2V9J A;  3EIK A;  3I0X A;  1W80 A;  1TGH A;  4WZS D;  1KO9 A;  1KFI A;  4D7Q A;  1PVS A;  1RM1 A;  2NOF A;  3OCI A;  3C04 A;  3BKQ X;  2YH5 A;  1KY6 A;  3ENO C;  2H5A X;  3OH6 A;  2JOI A;  3KTU A;  3RPJ A;  3OH9 A;  4EAJ A;  3TDH A;  4ROE B;  2FUV A;  3OSE A;  1YQL A;  1QN4 A;  2FKF A;  1QNA A;  3CWU A;  3ASM A;  5EPC A;  1CDW A;  1M5Q 1;  2VJ0 A;  3ENC A;  1NVP A;  1C9B B;  2HKP A;  4EAK A;  3VN5 A;  2PWW A;  5HSH A;  1QN3 A;  1YTB A;  1PZD A;  2ZFD B;  4WXA A;  2QLV A;  3HS8 A;  2Z8U A;  1J3M A;  3DPT A;  2NOH A;  1KY7 A;  2D0C A;  2OOY A;  4BJU A;  3TE5 A;  1AIS A;  1PCM X;  4HJH A;  4Q11 A;  1VKL A;  2JHJ A; 
#chains in the Genus database with same CATH homology
 4CFF A;  2Y8L A;  2YA3 A;  2Y8Q A;  2QRC A;  3T4N A;  4EAJ A;  3TDH A;  2EHB D;  4EAG A;  3OSE A;  1UL7 A;  2V92 A;  4EAK A;  2QRE A;  2V8Q A;  2ZFD B;  2OOX A;  2QLV A;  2QRD A;  2OOY A;  2QR1 A;  4EAI A;  2V9J A;  3TE5 A;  4EAL A;  1V5S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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