4EAJA

Co-crystal of ampk core with amp soaked with atp
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
100
structure length
100
Chain Sequence
AKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDGGGGGGGSHTIEFFEMCANLIKILA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
source organism Rattus norvegicus
publication title AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
pubmed doi rcsb
molecule keywords 5'-AMP-activated protein kinase catalytic subunit alpha-1
total genus 23
structure length 100
sequence length 100
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 4eajA01
3TE5A 1V5SA 2OOYA 3TDHA 2ZFDB 2YA3A 3T4NA 3OSEA 4CFFA 2OOXA 4EALA 2QRCA 2V9JA 4EAGA 2QR1A 4EAIA 2EHBD 2QREA 2QLVA 2Y8LA 4EAJA 2Y8QA 4EAKA 2V92A 2V8QA 1UL7A 2QRDA
chains in the Genus database with same CATH superfamily
1TBPA 5IYDP 1V5SA 1AISA 3RPJA 1TUOA 2F7LA 1K2YX 1WJWA 2JHJA 3D4VA 1D3UA 1QNEA 1R4XA 4D7RA 1QTSA 3HS9A 1QN9A 2H5AX 1RM1A 1EUVA 2NLVA 1KY6A 3CWTA 1T6AA 3UW2A 3OSEA 3OH6A 1YQLA 2Z0FA 1YQRA 3PMGA 2NOFA 4CFFA 1M5Q1 3VN5A 4DULA 1QN7A 1M3QA 1QNAA 2FGTA 2DKCA 3C04A 1QTPA 1PVSA 5IYBP 1YQMA 4MRQA 3N89A 2JOIA 1LWYA 1QNBA 2HKPA 2QREA 2QLVA 1QN5A 2Y8QA 1KFIA 2D0AA 3SNSA 2JPIA 1YTBA 3DPTA 3EIKA 4WZSD 1UL7A 2NOHA 2EHBD 2O3OA 4QG5A 1VOKA 2NOIA 2D0BA 3CW7A 3BKQX 3I3WA 2I5WA 3CWUA 2ZFDB 1PCJX 3KTUA 2R5XA 2NOBA 1P5DX 1VKLA 2VJ0A 3OSTA 3CVTA 4EJYA 1C9BB 3CWSA 1JFIC 2OOXA 4EALA 2V9JA 2QR1A 4I8OA 2DKDA 1PCZA 5IYCP 2MZ8A 2G30A 5BMPA 1HU0A 2NOLA 1QN8A 4TPSA 1KYUA 1LXTA 4EAKA 1NVPA 1MP9A 1QNCA 1CDWA 2HZSA 5EPCA 2HL9A 1KY7A 5HSHA 4PY5A 3TE5A 3NA5A 1XSZA 4D7QA 1QN6A 3F0ZA 1YTFA 3TDHA 2NOEA 4ROCB 2YA3A 1MPGA 3T4NA 3D7QA 5KL0A 1LWVA 5JMVD 1KYDA 3H1ZA 2NOZA 1K35A 1TBAB 3RSMA 4RODB 1PCMX 1JDYA 1UT4A 3I0WA 3I0XA 3F10A 3OLPA 4ROEB 4EAIA 2FUVA 3DPUA 4BJUA 1KO9A 1KYFA 2IV9A 2HZMA 2Y8LA 4EAJA 3CWAA 1EBMA 4HJHA 1QN4A 4IL8A 1VTOA 2LAEA 1E42A 2HL8A 2JHNA 3OSMA 4Q11A 1KFQA 2Z8UA 4C7PA 1M3HA 1WQAA 2V8QA 1VTLE 2FKMX 2QRDA 1C47A 3ENCA 1N3AA 1P5GX 2OOYA 5BMNA 5F9CA 1NGMA 1PZDA 5AN4A 1Q9UA 1FN7A 3KRMA 3IH7A 3OC3C 3HS8A 2DKAA 1NH2A 3OH9A 4WXAA 2IV8A 3PDKA 3ASMA 2NWVA 3OCIA 2QRCA 4WX8A 4B0AA 2D0CA 2FKFA 4EAGA 5JN5A 1VOLB 3ENOC 1N39A 1LWWA 1QN3A 2PWWA 1N3CA 3ULXA 3CVSA 2XHIA 1C4GA 1YQKA 3EAYA 2YH5A 1TGHA 2H4LX 2NVMA 1DIZA 3OGDA 4EJZA 1J3MA 2V92A 1W80A 2MJ7A 1UT7A 1B9KA
chains in the Genus database with same CATH topology
3TE5A 1V5SA 2OOYA 3TDHA 2ZFDB 2YA3A 3T4NA 3OSEA 4CFFA 2OOXA 4EALA 2QRCA 2V9JA 4EAGA 2QR1A 4EAIA 2EHBD 2QREA 2QLVA 2Y8LA 4EAJA 2Y8QA 4EAKA 2V92A 2V8QA 1UL7A 2QRDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TE5 A;  1V5S A;  2OOY A;  3TDH A;  2ZFD B;  2YA3 A;  3T4N A;  3OSE A;  4CFF A;  2OOX A;  4EAL A;  2QRC A;  2V9J A;  4EAG A;  2QR1 A;  4EAI A;  2EHB D;  2QRE A;  2QLV A;  2Y8L A;  4EAJ A;  2Y8Q A;  4EAK A;  2V92 A;  2V8Q A;  1UL7 A;  2QRD A; 
#chains in the Genus database with same CATH topology
 1TBP A;  5IYD P;  1V5S A;  1AIS A;  3RPJ A;  1TUO A;  2F7L A;  1K2Y X;  1WJW A;  2JHJ A;  3D4V A;  1D3U A;  1QNE A;  1R4X A;  4D7R A;  1QTS A;  3HS9 A;  1QN9 A;  2H5A X;  1RM1 A;  1EUV A;  2NLV A;  1KY6 A;  3CWT A;  1T6A A;  3UW2 A;  3OSE A;  3OH6 A;  1YQL A;  2Z0F A;  1YQR A;  3PMG A;  2NOF A;  4CFF A;  1M5Q 1;  3VN5 A;  4DUL A;  1QN7 A;  1M3Q A;  1QNA A;  2FGT A;  2DKC A;  3C04 A;  1QTP A;  1PVS A;  5IYB P;  1YQM A;  4MRQ A;  3N89 A;  2JOI A;  1LWY A;  1QNB A;  2HKP A;  2QRE A;  2QLV A;  1QN5 A;  2Y8Q A;  1KFI A;  2D0A A;  3SNS A;  2JPI A;  1YTB A;  3DPT A;  3EIK A;  4WZS D;  1UL7 A;  2NOH A;  2EHB D;  2O3O A;  4QG5 A;  1VOK A;  2NOI A;  2D0B A;  3CW7 A;  3BKQ X;  3I3W A;  2I5W A;  3CWU A;  2ZFD B;  1PCJ X;  3KTU A;  2R5X A;  2NOB A;  1P5D X;  1VKL A;  2VJ0 A;  3OST A;  3CVT A;  4EJY A;  1C9B B;  3CWS A;  1JFI C;  2OOX A;  4EAL A;  2V9J A;  2QR1 A;  4I8O A;  2DKD A;  1PCZ A;  5IYC P;  2MZ8 A;  2G30 A;  5BMP A;  1HU0 A;  2NOL A;  1QN8 A;  4TPS A;  1KYU A;  1LXT A;  4EAK A;  1NVP A;  1MP9 A;  1QNC A;  1CDW A;  2HZS A;  5EPC A;  2HL9 A;  1KY7 A;  5HSH A;  4PY5 A;  3TE5 A;  3NA5 A;  1XSZ A;  4D7Q A;  1QN6 A;  3F0Z A;  1YTF A;  3TDH A;  2NOE A;  4ROC B;  2YA3 A;  1MPG A;  3T4N A;  3D7Q A;  5KL0 A;  1LWV A;  5JMV D;  1KYD A;  3H1Z A;  2NOZ A;  1K35 A;  1TBA B;  3RSM A;  4ROD B;  1PCM X;  1JDY A;  1UT4 A;  3I0W A;  3I0X A;  3F10 A;  3OLP A;  4ROE B;  4EAI A;  2FUV A;  3DPU A;  4BJU A;  1KO9 A;  1KYF A;  2IV9 A;  2HZM A;  2Y8L A;  4EAJ A;  3CWA A;  1EBM A;  4HJH A;  1QN4 A;  4IL8 A;  1VTO A;  2LAE A;  1E42 A;  2HL8 A;  2JHN A;  3OSM A;  4Q11 A;  1KFQ A;  2Z8U A;  4C7P A;  1M3H A;  1WQA A;  2V8Q A;  1VTL E;  2FKM X;  2QRD A;  1C47 A;  3ENC A;  1N3A A;  1P5G X;  2OOY A;  5BMN A;  5F9C A;  1NGM A;  1PZD A;  5AN4 A;  1Q9U A;  1FN7 A;  3KRM A;  3IH7 A;  3OC3 C;  3HS8 A;  2DKA A;  1NH2 A;  3OH9 A;  4WXA A;  2IV8 A;  3PDK A;  3ASM A;  2NWV A;  3OCI A;  2QRC A;  4WX8 A;  4B0A A;  2D0C A;  2FKF A;  4EAG A;  5JN5 A;  1VOL B;  3ENO C;  1N39 A;  1LWW A;  1QN3 A;  2PWW A;  1N3C A;  3ULX A;  3CVS A;  2XHI A;  1C4G A;  1YQK A;  3EAY A;  2YH5 A;  1TGH A;  2H4L X;  2NVM A;  1DIZ A;  3OGD A;  4EJZ A;  1J3M A;  2V92 A;  1W80 A;  2MJ7 A;  1UT7 A;  1B9K A; 
#chains in the Genus database with same CATH homology
 3TE5 A;  1V5S A;  2OOY A;  3TDH A;  2ZFD B;  2YA3 A;  3T4N A;  3OSE A;  4CFF A;  2OOX A;  4EAL A;  2QRC A;  2V9J A;  4EAG A;  2QR1 A;  4EAI A;  2EHB D;  2QRE A;  2QLV A;  2Y8L A;  4EAJ A;  2Y8Q A;  4EAK A;  2V92 A;  2V8Q A;  1UL7 A;  2QRD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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