4EAKA

Co-crystal structure of an ampk core with atp
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
99
structure length
92
Chain Sequence
WHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDGSHTIEFFEMCANLIKILAQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
pubmed doi rcsb
molecule tags Transferase
source organism Rattus norvegicus
molecule keywords 5'-AMP-activated protein kinase catalytic subunit alpha-1
total genus 21
structure length 92
sequence length 99
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 4eakA01
3T4NA 3TDHA 3OSEA 4EAJA 2QREA 2V8QA 2QRCA 2QR1A 2ZFDB 2EHBD 4EAIA 2Y8LA 1V5SA 4EAKA 4EAGA 2OOYA 2QLVA 2QRDA 2V92A 2Y8QA 2YA3A 4EALA 4CFFA 2OOXA 3TE5A 2V9JA 1UL7A
chains in the Genus database with same CATH superfamily
2HZMA 1CDWA 3H1ZA 1TUOA 1PZDA 2NOEA 1E42A 2IV9A 2NOBA 2V8QA 2DKDA 4EJYA 5JN5A 3OH6A 2XHIA 5IYDP 2O3OA 3F10A 1QTSA 3N89A 2PWWA 3OCIA 4EAIA 2JOIA 5JMVD 1C47A 3PMGA 1EUVA 3CVTA 1QN7A 1HU0A 2I5WA 1QTPA 1FN7A 2NWVA 1VOKA 5IYBP 1NVPA 1VOLB 1J3MA 2NOFA 1PVSA 2QRDA 2JHJA 4I8OA 1YTBA 5F9CA 1T6AA 1PCMX 3OSTA 1DIZA 2MJ7A 3DPTA 4D7QA 1LXTA 2NVMA 5BMPA 1D3UA 1M3QA 1P5DX 1YQLA 1KY6A 1KY7A 1C4GA 1N3CA 1WQAA 2HKPA 1VKLA 3CWUA 1QN9A 2G30A 1UT7A 1LWVA 4PY5A 4DULA 2QREA 3C04A 3IH7A 3I0XA 4EJZA 3BKQX 1M3HA 1Q9UA 3OC3C 2EHBD 3PDKA 2Z0FA 1YQKA 3NA5A 4BJUA 3CWAA 3CWTA 2YH5A 4WZSD 3DPUA 1RM1A 2OOYA 3ASMA 1UT4A 3CVSA 1QNAA 1JDYA 1PCZA 2H4LX 2R5XA 2YA3A 1K35A 1TBPA 4TPSA 4CFFA 1QN3A 2OOXA 1NH2A 1VTLE 1W80A 3I3WA 2NOHA 1KYDA 1PCJX 1K2YX 4D7RA 1LWWA 4RODB 3HS9A 3ULXA 5KL0A 2IV8A 3T4NA 2FGTA 2Z8UA 3KRMA 2VJ0A 1QN6A 5BMNA 3OSEA 4Q11A 3VN5A 3OGDA 3F0ZA 1MPGA 2H5AX 3KTUA 4QG5A 2D0CA 1EBMA 3ENCA 1R4XA 2NOLA 5AN4A 4EAKA 1C9BB 1KFQA 2D0BA 2QLVA 4EALA 1KO9A 1JFIC 2HL9A 1KFIA 2FKFA 1XSZA 3ENOC 1VTOA 3HS8A 3D7QA 2MZ8A 3OSMA 2FKMX 4C7PA 2V9JA 3OH9A 1N39A 4WXAA 2LAEA 1P5GX 1N3AA 1QN5A 5EPCA 1TBAB 1KYFA 2D0AA 3TDHA 4EAJA 2NOIA 3RPJA 2NLVA 3RSMA 1TGHA 4WX8A 2QRCA 3D4VA 3CW7A 1B9KA 2QR1A 2ZFDB 2JHNA 4IL8A 1QNEA 1M5Q1 2FUVA 1NGMA 5HSHA 1KYUA 1QN8A 1MP9A 2JPIA 2Y8LA 1V5SA 2HZSA 2NOZA 3CWSA 4EAGA 4B0AA 2DKCA 4ROEB 1AISA 1QN4A 3EIKA 2V92A 2Y8QA 3I0WA 1WJWA 3OLPA 5IYCP 1QNCA 3TE5A 3UW2A 4ROCB 4MRQA 1UL7A 3SNSA 2HL8A 2F7LA 4HJHA 1YQMA 1QNBA 2DKAA 1LWYA 3EAYA 1YTFA 1YQRA
chains in the Genus database with same CATH topology
3T4NA 3TDHA 3OSEA 4EAJA 2QREA 2V8QA 2QRCA 2QR1A 2ZFDB 2EHBD 4EAIA 2Y8LA 1V5SA 4EAKA 4EAGA 2OOYA 2QLVA 2QRDA 2V92A 2Y8QA 2YA3A 4EALA 4CFFA 2OOXA 3TE5A 2V9JA 1UL7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T4N A;  3TDH A;  3OSE A;  4EAJ A;  2QRE A;  2V8Q A;  2QRC A;  2QR1 A;  2ZFD B;  2EHB D;  4EAI A;  2Y8L A;  1V5S A;  4EAK A;  4EAG A;  2OOY A;  2QLV A;  2QRD A;  2V92 A;  2Y8Q A;  2YA3 A;  4EAL A;  4CFF A;  2OOX A;  3TE5 A;  2V9J A;  1UL7 A; 
#chains in the Genus database with same CATH topology
 2HZM A;  1CDW A;  3H1Z A;  1TUO A;  1PZD A;  2NOE A;  1E42 A;  2IV9 A;  2NOB A;  2V8Q A;  2DKD A;  4EJY A;  5JN5 A;  3OH6 A;  2XHI A;  5IYD P;  2O3O A;  3F10 A;  1QTS A;  3N89 A;  2PWW A;  3OCI A;  4EAI A;  2JOI A;  5JMV D;  1C47 A;  3PMG A;  1EUV A;  3CVT A;  1QN7 A;  1HU0 A;  2I5W A;  1QTP A;  1FN7 A;  2NWV A;  1VOK A;  5IYB P;  1NVP A;  1VOL B;  1J3M A;  2NOF A;  1PVS A;  2QRD A;  2JHJ A;  4I8O A;  1YTB A;  5F9C A;  1T6A A;  1PCM X;  3OST A;  1DIZ A;  2MJ7 A;  3DPT A;  4D7Q A;  1LXT A;  2NVM A;  5BMP A;  1D3U A;  1M3Q A;  1P5D X;  1YQL A;  1KY6 A;  1KY7 A;  1C4G A;  1N3C A;  1WQA A;  2HKP A;  1VKL A;  3CWU A;  1QN9 A;  2G30 A;  1UT7 A;  1LWV A;  4PY5 A;  4DUL A;  2QRE A;  3C04 A;  3IH7 A;  3I0X A;  4EJZ A;  3BKQ X;  1M3H A;  1Q9U A;  3OC3 C;  2EHB D;  3PDK A;  2Z0F A;  1YQK A;  3NA5 A;  4BJU A;  3CWA A;  3CWT A;  2YH5 A;  4WZS D;  3DPU A;  1RM1 A;  2OOY A;  3ASM A;  1UT4 A;  3CVS A;  1QNA A;  1JDY A;  1PCZ A;  2H4L X;  2R5X A;  2YA3 A;  1K35 A;  1TBP A;  4TPS A;  4CFF A;  1QN3 A;  2OOX A;  1NH2 A;  1VTL E;  1W80 A;  3I3W A;  2NOH A;  1KYD A;  1PCJ X;  1K2Y X;  4D7R A;  1LWW A;  4ROD B;  3HS9 A;  3ULX A;  5KL0 A;  2IV8 A;  3T4N A;  2FGT A;  2Z8U A;  3KRM A;  2VJ0 A;  1QN6 A;  5BMN A;  3OSE A;  4Q11 A;  3VN5 A;  3OGD A;  3F0Z A;  1MPG A;  2H5A X;  3KTU A;  4QG5 A;  2D0C A;  1EBM A;  3ENC A;  1R4X A;  2NOL A;  5AN4 A;  4EAK A;  1C9B B;  1KFQ A;  2D0B A;  2QLV A;  4EAL A;  1KO9 A;  1JFI C;  2HL9 A;  1KFI A;  2FKF A;  1XSZ A;  3ENO C;  1VTO A;  3HS8 A;  3D7Q A;  2MZ8 A;  3OSM A;  2FKM X;  4C7P A;  2V9J A;  3OH9 A;  1N39 A;  4WXA A;  2LAE A;  1P5G X;  1N3A A;  1QN5 A;  5EPC A;  1TBA B;  1KYF A;  2D0A A;  3TDH A;  4EAJ A;  2NOI A;  3RPJ A;  2NLV A;  3RSM A;  1TGH A;  4WX8 A;  2QRC A;  3D4V A;  3CW7 A;  1B9K A;  2QR1 A;  2ZFD B;  2JHN A;  4IL8 A;  1QNE A;  1M5Q 1;  2FUV A;  1NGM A;  5HSH A;  1KYU A;  1QN8 A;  1MP9 A;  2JPI A;  2Y8L A;  1V5S A;  2HZS A;  2NOZ A;  3CWS A;  4EAG A;  4B0A A;  2DKC A;  4ROE B;  1AIS A;  1QN4 A;  3EIK A;  2V92 A;  2Y8Q A;  3I0W A;  1WJW A;  3OLP A;  5IYC P;  1QNC A;  3TE5 A;  3UW2 A;  4ROC B;  4MRQ A;  1UL7 A;  3SNS A;  2HL8 A;  2F7L A;  4HJH A;  1YQM A;  1QNB A;  2DKA A;  1LWY A;  3EAY A;  1YTF A;  1YQR A; 
#chains in the Genus database with same CATH homology
 3T4N A;  3TDH A;  3OSE A;  4EAJ A;  2QRE A;  2V8Q A;  2QRC A;  2QR1 A;  2ZFD B;  2EHB D;  4EAI A;  2Y8L A;  1V5S A;  4EAK A;  4EAG A;  2OOY A;  2QLV A;  2QRD A;  2V92 A;  2Y8Q A;  2YA3 A;  4EAL A;  4CFF A;  2OOX A;  3TE5 A;  2V9J A;  1UL7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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