4EALA

Co-crystal of ampk core with atp soaked with amp
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
99
structure length
92
Chain Sequence
WHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDGSHTIEFFEMCANLIKILAQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
pubmed doi rcsb
molecule tags Transferase
source organism Rattus norvegicus
molecule keywords 5'-AMP-activated protein kinase catalytic subunit alpha-1
total genus 21
structure length 92
sequence length 99
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 4ealA01
2QREA 4CFFA 3TE5A 2OOXA 1V5SA 2QRCA 2EHBD 2V8QA 2V9JA 2Y8LA 1UL7A 2OOYA 2QR1A 2YA3A 3OSEA 4EAJA 3TDHA 3T4NA 2QLVA 4EAIA 2ZFDB 4EALA 2Y8QA 2QRDA 4EAKA 4EAGA 2V92A
chains in the Genus database with same CATH superfamily
2NOZA 1J3MA 1N3AA 1KYUA 1LWWA 3CW7A 2HKPA 4ROEB 2F7LA 1PVSA 3CWUA 1E42A 3OCIA 2NWVA 3C04A 1P5GX 2DKCA 1R4XA 1VTOA 3RSMA 3OH6A 1QN9A 3CWAA 1HU0A 3KRMA 3OSEA 3F0ZA 3TDHA 5IYCP 1VOLB 1EUVA 2XHIA 2IV9A 3HS8A 1FN7A 1T6AA 4WXAA 3CWSA 3OC3C 4Q11A 5EPCA 2ZFDB 3KTUA 5BMPA 4EALA 5HSHA 2HL8A 4WZSD 2DKDA 2JHNA 4D7RA 1RM1A 2QRDA 5AN4A 2IV8A 1KO9A 4TPSA 1PCJX 2Z0FA 1AISA 1D3UA 1VOKA 2NOLA 2QREA 2Z8UA 5BMNA 3IH7A 3OSTA 1YTFA 1TBPA 1K35A 1P5DX 2HZSA 1KYFA 5JN5A 3PMGA 1NGMA 1JFIC 1V5SA 2QRCA 1PCMX 2H4LX 4EJZA 2D0CA 2QR1A 1QNEA 3D7QA 1NH2A 2NVMA 3ULXA 1B9KA 2HL9A 1M5Q1 1Q9UA 4HJHA 1TGHA 1WJWA 4ROCB 4EAJA 1QTSA 2DKAA 2NOHA 2YH5A 3UW2A 1PZDA 4RODB 3BKQX 3OGDA 1EBMA 3OLPA 5JMVD 1TUOA 3CWTA 2HZMA 3ENOC 3PDKA 4DULA 2R5XA 1C47A 4MRQA 1MPGA 3OH9A 1QN4A 1QN8A 2I5WA 1CDWA 1WQAA 1KY7A 4C7PA 1UL7A 3EIKA 4EAGA 1LWVA 2NOFA 4CFFA 1UT7A 1KYDA 3TE5A 2FKFA 4QG5A 2O3OA 1YQLA 1YTBA 2V9JA 4EJYA 2OOYA 3NA5A 2NOEA 1QN3A 1PCZA 1K2YX 1UT4A 2NOBA 2FKMX 1KFIA 3CVSA 2JPIA 1YQRA 2D0AA 3T4NA 3EAYA 1N39A 3F10A 5IYBP 1N3CA 1DIZA 2MJ7A 1TBAB 1YQMA 4PY5A 2FGTA 3N89A 1QN5A 2H5AX 2MZ8A 2Y8QA 3ENCA 1C4GA 1LWYA 3HS9A 1QNBA 2JHJA 2D0BA 1KFQA 1W80A 2NLVA 4BJUA 1C9BB 1VTLE 1YQKA 1QN6A 2OOXA 3ASMA 3VN5A 2EHBD 4WX8A 2V8QA 4IL8A 1JDYA 2Y8LA 3DPUA 3I3WA 4B0AA 3D4VA 3SNSA 2JOIA 4D7QA 5F9CA 5IYDP 5KL0A 2VJ0A 2YA3A 1QTPA 4I8OA 1QN7A 1VKLA 3OSMA 1QNCA 1MP9A 1QNAA 1KY6A 2NOIA 2QLVA 1M3QA 2G30A 3DPTA 4EAIA 1NVPA 1LXTA 3I0WA 2FUVA 1M3HA 3H1ZA 1XSZA 2LAEA 3CVTA 2PWWA 3RPJA 3I0XA 4EAKA 2V92A
chains in the Genus database with same CATH topology
2QREA 4CFFA 3TE5A 2OOXA 1V5SA 2QRCA 2EHBD 2V8QA 2V9JA 2Y8LA 1UL7A 2OOYA 2QR1A 2YA3A 3OSEA 4EAJA 3TDHA 3T4NA 2QLVA 4EAIA 2ZFDB 4EALA 2Y8QA 2QRDA 4EAKA 4EAGA 2V92A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QRE A;  4CFF A;  3TE5 A;  2OOX A;  1V5S A;  2QRC A;  2EHB D;  2V8Q A;  2V9J A;  2Y8L A;  1UL7 A;  2OOY A;  2QR1 A;  2YA3 A;  3OSE A;  4EAJ A;  3TDH A;  3T4N A;  2QLV A;  4EAI A;  2ZFD B;  4EAL A;  2Y8Q A;  2QRD A;  4EAK A;  4EAG A;  2V92 A; 
#chains in the Genus database with same CATH topology
 2NOZ A;  1J3M A;  1N3A A;  1KYU A;  1LWW A;  3CW7 A;  2HKP A;  4ROE B;  2F7L A;  1PVS A;  3CWU A;  1E42 A;  3OCI A;  2NWV A;  3C04 A;  1P5G X;  2DKC A;  1R4X A;  1VTO A;  3RSM A;  3OH6 A;  1QN9 A;  3CWA A;  1HU0 A;  3KRM A;  3OSE A;  3F0Z A;  3TDH A;  5IYC P;  1VOL B;  1EUV A;  2XHI A;  2IV9 A;  3HS8 A;  1FN7 A;  1T6A A;  4WXA A;  3CWS A;  3OC3 C;  4Q11 A;  5EPC A;  2ZFD B;  3KTU A;  5BMP A;  4EAL A;  5HSH A;  2HL8 A;  4WZS D;  2DKD A;  2JHN A;  4D7R A;  1RM1 A;  2QRD A;  5AN4 A;  2IV8 A;  1KO9 A;  4TPS A;  1PCJ X;  2Z0F A;  1AIS A;  1D3U A;  1VOK A;  2NOL A;  2QRE A;  2Z8U A;  5BMN A;  3IH7 A;  3OST A;  1YTF A;  1TBP A;  1K35 A;  1P5D X;  2HZS A;  1KYF A;  5JN5 A;  3PMG A;  1NGM A;  1JFI C;  1V5S A;  2QRC A;  1PCM X;  2H4L X;  4EJZ A;  2D0C A;  2QR1 A;  1QNE A;  3D7Q A;  1NH2 A;  2NVM A;  3ULX A;  1B9K A;  2HL9 A;  1M5Q 1;  1Q9U A;  4HJH A;  1TGH A;  1WJW A;  4ROC B;  4EAJ A;  1QTS A;  2DKA A;  2NOH A;  2YH5 A;  3UW2 A;  1PZD A;  4ROD B;  3BKQ X;  3OGD A;  1EBM A;  3OLP A;  5JMV D;  1TUO A;  3CWT A;  2HZM A;  3ENO C;  3PDK A;  4DUL A;  2R5X A;  1C47 A;  4MRQ A;  1MPG A;  3OH9 A;  1QN4 A;  1QN8 A;  2I5W A;  1CDW A;  1WQA A;  1KY7 A;  4C7P A;  1UL7 A;  3EIK A;  4EAG A;  1LWV A;  2NOF A;  4CFF A;  1UT7 A;  1KYD A;  3TE5 A;  2FKF A;  4QG5 A;  2O3O A;  1YQL A;  1YTB A;  2V9J A;  4EJY A;  2OOY A;  3NA5 A;  2NOE A;  1QN3 A;  1PCZ A;  1K2Y X;  1UT4 A;  2NOB A;  2FKM X;  1KFI A;  3CVS A;  2JPI A;  1YQR A;  2D0A A;  3T4N A;  3EAY A;  1N39 A;  3F10 A;  5IYB P;  1N3C A;  1DIZ A;  2MJ7 A;  1TBA B;  1YQM A;  4PY5 A;  2FGT A;  3N89 A;  1QN5 A;  2H5A X;  2MZ8 A;  2Y8Q A;  3ENC A;  1C4G A;  1LWY A;  3HS9 A;  1QNB A;  2JHJ A;  2D0B A;  1KFQ A;  1W80 A;  2NLV A;  4BJU A;  1C9B B;  1VTL E;  1YQK A;  1QN6 A;  2OOX A;  3ASM A;  3VN5 A;  2EHB D;  4WX8 A;  2V8Q A;  4IL8 A;  1JDY A;  2Y8L A;  3DPU A;  3I3W A;  4B0A A;  3D4V A;  3SNS A;  2JOI A;  4D7Q A;  5F9C A;  5IYD P;  5KL0 A;  2VJ0 A;  2YA3 A;  1QTP A;  4I8O A;  1QN7 A;  1VKL A;  3OSM A;  1QNC A;  1MP9 A;  1QNA A;  1KY6 A;  2NOI A;  2QLV A;  1M3Q A;  2G30 A;  3DPT A;  4EAI A;  1NVP A;  1LXT A;  3I0W A;  2FUV A;  1M3H A;  3H1Z A;  1XSZ A;  2LAE A;  3CVT A;  2PWW A;  3RPJ A;  3I0X A;  4EAK A;  2V92 A; 
#chains in the Genus database with same CATH homology
 2QRE A;  4CFF A;  3TE5 A;  2OOX A;  1V5S A;  2QRC A;  2EHB D;  2V8Q A;  2V9J A;  2Y8L A;  1UL7 A;  2OOY A;  2QR1 A;  2YA3 A;  3OSE A;  4EAJ A;  3TDH A;  3T4N A;  2QLV A;  4EAI A;  2ZFD B;  4EAL A;  2Y8Q A;  2QRD A;  4EAK A;  4EAG A;  2V92 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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