4EAJA

Co-crystal of ampk core with amp soaked with atp
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
100
structure length
100
Chain Sequence
AKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDGGGGGGGSHTIEFFEMCANLIKILA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
pubmed doi rcsb
molecule tags Transferase
source organism Rattus norvegicus
molecule keywords 5'-AMP-activated protein kinase catalytic subunit alpha-1
total genus 23
structure length 100
sequence length 100
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 4eajA01
2OOYA 4EAGA 4EALA 2QRCA 2YA3A 4EAIA 4EAKA 2EHBD 2QREA 2V8QA 2QRDA 3T4NA 2OOXA 2ZFDB 2V92A 3TE5A 2Y8LA 4EAJA 2Y8QA 3OSEA 2QLVA 1UL7A 2V9JA 2QR1A 3TDHA 4CFFA 1V5SA
chains in the Genus database with same CATH superfamily
2IV9A 1LWYA 2FUVA 4EAGA 2HZSA 2Z0FA 1Q9UA 1UT7A 1QNEA 4D7QA 1P5GX 4PY5A 2ZFDB 3ASMA 3ENOC 4IL8A 5EPCA 1B9KA 2FKFA 1TBPA 2IV8A 2JHNA 3VN5A 4WZSD 3CWAA 1KYUA 3OH9A 3CWTA 5JN5A 1KYFA 3H1ZA 2MJ7A 5JMVD 1QNAA 1QN6A 4ROCB 1QN7A 2NOIA 2QLVA 2DKAA 5F9CA 4BJUA 2I5WA 3CVSA 2NOHA 3TDHA 3I0WA 1J3MA 3KTUA 4I8OA 1T6AA 1YTBA 1YQMA 4EJZA 1QN8A 3CW7A 4EAIA 2LAEA 1PCJX 4EAKA 1QN5A 4EJYA 2QREA 3OSMA 1NH2A 2JOIA 4C7PA 1KO9A 1W80A 1EBMA 2NOBA 2NWVA 3EIKA 1N3AA 5AN4A 1KY6A 2HL9A 2JPIA 2NOZA 2Y8LA 4TPSA 2D0AA 1TBAB 2PWWA 3KRMA 3EAYA 3ENCA 2F7LA 3BKQX 5BMNA 2FGTA 3C04A 1QNCA 1YQRA 3OSEA 1NVPA 3PMGA 2NOEA 5IYCP 4B0AA 1YTFA 1UL7A 2MZ8A 2V9JA 1JDYA 2QR1A 1HU0A 1K35A 2D0CA 2NOFA 1KYDA 4CFFA 2HKPA 3DPUA 3ULXA 1V5SA 1TGHA 2OOYA 1KY7A 3NA5A 2QRCA 4EALA 2NOLA 1MPGA 3HS9A 1M5Q1 1XSZA 3OSTA 1CDWA 1QN4A 5BMPA 1M3QA 2HZMA 2JHJA 2DKCA 2D0BA 2V8QA 2QRDA 3RSMA 1C4GA 2OOXA 1M3HA 3CWSA 1YQKA 2V92A 1P5DX 1DIZA 5KL0A 1E42A 4EAJA 3OGDA 1VTOA 2Y8QA 1QN9A 5IYDP 5HSHA 1R4XA 2HL8A 2VJ0A 1VOLB 1QTSA 4RODB 1YQLA 1WJWA 3IH7A 4HJHA 3OLPA 3I3WA 1N3CA 1K2YX 1VKLA 1MP9A 4QG5A 2H5AX 4WXAA 1NGMA 3I0XA 1C47A 5IYBP 2H4LX 2NLVA 1C9BB 2G30A 1FN7A 1N39A 1PCZA 2YA3A 4ROEB 4MRQA 2YH5A 1LXTA 1KFQA 1PZDA 2EHBD 1VTLE 3OCIA 4DULA 1EUVA 2FKMX 1QNBA 2XHIA 3UW2A 3T4NA 3D7QA 3N89A 4D7RA 3DPTA 3CWUA 3SNSA 1AISA 1JFIC 1KFIA 1VOKA 3TE5A 1WQAA 2NVMA 2O3OA 3CVTA 3F10A 1LWVA 3D4VA 1QTPA 1QN3A 2Z8UA 1UT4A 1PCMX 1RM1A 4WX8A 1TUOA 3RPJA 3PDKA 1D3UA 1LWWA 3OC3C 3F0ZA 3OH6A 1PVSA 2DKDA 3HS8A 2R5XA 4Q11A
chains in the Genus database with same CATH topology
2OOYA 4EAGA 4EALA 2QRCA 2YA3A 4EAIA 4EAKA 2EHBD 2QREA 2V8QA 2QRDA 3T4NA 2OOXA 2ZFDB 2V92A 3TE5A 2Y8LA 4EAJA 2Y8QA 3OSEA 2QLVA 1UL7A 2V9JA 2QR1A 3TDHA 4CFFA 1V5SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OOY A;  4EAG A;  4EAL A;  2QRC A;  2YA3 A;  4EAI A;  4EAK A;  2EHB D;  2QRE A;  2V8Q A;  2QRD A;  3T4N A;  2OOX A;  2ZFD B;  2V92 A;  3TE5 A;  2Y8L A;  4EAJ A;  2Y8Q A;  3OSE A;  2QLV A;  1UL7 A;  2V9J A;  2QR1 A;  3TDH A;  4CFF A;  1V5S A; 
#chains in the Genus database with same CATH topology
 2IV9 A;  1LWY A;  2FUV A;  4EAG A;  2HZS A;  2Z0F A;  1Q9U A;  1UT7 A;  1QNE A;  4D7Q A;  1P5G X;  4PY5 A;  2ZFD B;  3ASM A;  3ENO C;  4IL8 A;  5EPC A;  1B9K A;  2FKF A;  1TBP A;  2IV8 A;  2JHN A;  3VN5 A;  4WZS D;  3CWA A;  1KYU A;  3OH9 A;  3CWT A;  5JN5 A;  1KYF A;  3H1Z A;  2MJ7 A;  5JMV D;  1QNA A;  1QN6 A;  4ROC B;  1QN7 A;  2NOI A;  2QLV A;  2DKA A;  5F9C A;  4BJU A;  2I5W A;  3CVS A;  2NOH A;  3TDH A;  3I0W A;  1J3M A;  3KTU A;  4I8O A;  1T6A A;  1YTB A;  1YQM A;  4EJZ A;  1QN8 A;  3CW7 A;  4EAI A;  2LAE A;  1PCJ X;  4EAK A;  1QN5 A;  4EJY A;  2QRE A;  3OSM A;  1NH2 A;  2JOI A;  4C7P A;  1KO9 A;  1W80 A;  1EBM A;  2NOB A;  2NWV A;  3EIK A;  1N3A A;  5AN4 A;  1KY6 A;  2HL9 A;  2JPI A;  2NOZ A;  2Y8L A;  4TPS A;  2D0A A;  1TBA B;  2PWW A;  3KRM A;  3EAY A;  3ENC A;  2F7L A;  3BKQ X;  5BMN A;  2FGT A;  3C04 A;  1QNC A;  1YQR A;  3OSE A;  1NVP A;  3PMG A;  2NOE A;  5IYC P;  4B0A A;  1YTF A;  1UL7 A;  2MZ8 A;  2V9J A;  1JDY A;  2QR1 A;  1HU0 A;  1K35 A;  2D0C A;  2NOF A;  1KYD A;  4CFF A;  2HKP A;  3DPU A;  3ULX A;  1V5S A;  1TGH A;  2OOY A;  1KY7 A;  3NA5 A;  2QRC A;  4EAL A;  2NOL A;  1MPG A;  3HS9 A;  1M5Q 1;  1XSZ A;  3OST A;  1CDW A;  1QN4 A;  5BMP A;  1M3Q A;  2HZM A;  2JHJ A;  2DKC A;  2D0B A;  2V8Q A;  2QRD A;  3RSM A;  1C4G A;  2OOX A;  1M3H A;  3CWS A;  1YQK A;  2V92 A;  1P5D X;  1DIZ A;  5KL0 A;  1E42 A;  4EAJ A;  3OGD A;  1VTO A;  2Y8Q A;  1QN9 A;  5IYD P;  5HSH A;  1R4X A;  2HL8 A;  2VJ0 A;  1VOL B;  1QTS A;  4ROD B;  1YQL A;  1WJW A;  3IH7 A;  4HJH A;  3OLP A;  3I3W A;  1N3C A;  1K2Y X;  1VKL A;  1MP9 A;  4QG5 A;  2H5A X;  4WXA A;  1NGM A;  3I0X A;  1C47 A;  5IYB P;  2H4L X;  2NLV A;  1C9B B;  2G30 A;  1FN7 A;  1N39 A;  1PCZ A;  2YA3 A;  4ROE B;  4MRQ A;  2YH5 A;  1LXT A;  1KFQ A;  1PZD A;  2EHB D;  1VTL E;  3OCI A;  4DUL A;  1EUV A;  2FKM X;  1QNB A;  2XHI A;  3UW2 A;  3T4N A;  3D7Q A;  3N89 A;  4D7R A;  3DPT A;  3CWU A;  3SNS A;  1AIS A;  1JFI C;  1KFI A;  1VOK A;  3TE5 A;  1WQA A;  2NVM A;  2O3O A;  3CVT A;  3F10 A;  1LWV A;  3D4V A;  1QTP A;  1QN3 A;  2Z8U A;  1UT4 A;  1PCM X;  1RM1 A;  4WX8 A;  1TUO A;  3RPJ A;  3PDK A;  1D3U A;  1LWW A;  3OC3 C;  3F0Z A;  3OH6 A;  1PVS A;  2DKD A;  3HS8 A;  2R5X A;  4Q11 A; 
#chains in the Genus database with same CATH homology
 2OOY A;  4EAG A;  4EAL A;  2QRC A;  2YA3 A;  4EAI A;  4EAK A;  2EHB D;  2QRE A;  2V8Q A;  2QRD A;  3T4N A;  2OOX A;  2ZFD B;  2V92 A;  3TE5 A;  2Y8L A;  4EAJ A;  2Y8Q A;  3OSE A;  2QLV A;  1UL7 A;  2V9J A;  2QR1 A;  3TDH A;  4CFF A;  1V5S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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