5IYCP

Human core-pic in the initial transcribing state
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
185
structure length
185
Chain Sequence
TPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Near-atomic resolution visualization of human transcription promoter opening.
pubmed doi rcsb
molecule tags Transcription, transferase/dna
source organism Homo sapiens
molecule keywords DNA-directed RNA polymerase II subunit RPB1
total genus 44
structure length 185
sequence length 185
ec nomenclature
pdb deposition date 2016-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00352 TBP Transcription factor TFIID (or TATA-binding protein, TBP)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.10 Alpha Beta 2-Layer Sandwich TATA-Binding Protein TATA-Binding Protein 5iycP01
3.30.310.10 Alpha Beta 2-Layer Sandwich TATA-Binding Protein TATA-Binding Protein 5iycP02
2Z8UA 1KYFA 1KYDA 3VN5A 1D3UA 1QNBA 3ASMA 3HS8A 1B9KA 1NVPA 1QN4A 1VOLB 1R4XA 1TGHA 5IYDP 1KY6A 4RODB 1QN5A 1PCZA 1QN6A 2D0CA 1QN7A 1QN8A 2G30A 2MJ7A 1E42A 1KYUA 2IV8A 1NGMA 3OC3C 3H1ZA 1TBAB 1VTOA 1YTFA 1NH2A 3HS9A 1C9BB 4B0AA 2D0AA 1QN3A 1W80A 2IV9A 1VOKA 5IYCP 1QTPA 1QNCA 1VTLE 5IYBP 1QN9A 2VJ0A 1QNEA 1JFIC 4WZSD 1QTSA 4PY5A 1MP9A 3EIKA 2D0BA 4ROEB 4ROCB 3OCIA 1CDWA 1QNAA 1RM1A 1YTBA 1TBPA 1AISA 1PZDA 1KY7A
chains in the Genus database with same CATH superfamily
3OGDA 2Y8QA 4EALA 1YQRA 1VOLB 1EBMA 1Q9UA 2QRDA 1QN5A 1PCJX 2NOBA 2NOZA 1KFQA 5EPCA 2MJ7A 4I8OA 1LXTA 1PCMX 1E42A 3ENOC 2IV8A 1N3CA 2NLVA 1KFIA 1UL7A 3UW2A 2YA3A 1YTFA 3BKQX 3C04A 3HS9A 1C9BB 4B0AA 2F7LA 4EAIA 1W80A 2JPIA 1JDYA 2VJ0A 1C47A 1V5SA 2NOLA 2QRCA 3ENCA 1QTSA 2D0BA 5AN4A 1KO9A 1QNAA 1TUOA 2NOFA 1PZDA 1JFIC 1KY7A 1EUVA 2Z0FA 1QNBA 1MPGA 2FKFA 2QR1A 1LWYA 3TDHA 1KY6A 1TGHA 2YH5A 2EHBD 1PCZA 3OSTA 2DKDA 2R5XA 3CWTA 4EJYA 2PWWA 1UT4A 5JMVD 3CWUA 3DPUA 3CW7A 2IV9A 1T6AA 2LAEA 1VOKA 1P5DX 3NA5A 4MRQA 5IYCP 1K35A 3DPTA 2HL8A 4D7QA 2V9JA 2FKMX 2HZSA 3I0XA 5F9CA 2NVMA 4EAJA 4ROCB 2QREA 3CVTA 3EAYA 3OLPA 4DULA 1QNCA 1M3HA 3N89A 2Z8UA 3F0ZA 1KYDA 3CWAA 3HS8A 1UT7A 3T4NA 2MZ8A 4IL8A 1R4XA 4D7RA 4RODB 1YQKA 2D0CA 1FN7A 1QN7A 2G30A 3PDKA 2HZMA 3OH6A 2FUVA 3OC3C 2QLVA 3KRMA 1TBAB 3OSMA 1NH2A 1N39A 1J3MA 3PMGA 2D0AA 3SNSA 1C4GA 2ZFDB 1WJWA 1XSZA 3OSEA 1VTLE 5IYBP 4EAKA 1QN9A 4WXAA 1PVSA 2JHJA 4Q11A 1DIZA 5JN5A 1K2YX 2DKCA 1MP9A 4ROEB 1LWVA 3OCIA 3RSMA 1CDWA 2NOIA 4BJUA 1RM1A 2Y8LA 4QG5A 2HKPA 1TBPA 2XHIA 1AISA 1YTBA 2I5WA 1KYFA 5BMPA 5KL0A 3VN5A 3I0WA 2OOXA 3ASMA 1D3UA 2V92A 2NOHA 1NVPA 4CFFA 5HSHA 1QN4A 4TPSA 3KTUA 5IYDP 1P5GX 2JOIA 1QN6A 1N3AA 1QN8A 2NWVA 3D7QA 1HU0A 1KYUA 1NGMA 3ULXA 3OH9A 3I3WA 1WQAA 3H1ZA 4HJHA 1YQMA 4WX8A 1VTOA 2HL9A 3RPJA 4C7PA 3TE5A 3CWSA 1VKLA 3IH7A 1QN3A 3CVSA 1M5Q1 3F10A 1LWWA 5BMNA 1QTPA 1M3QA 4EJZA 1QNEA 2NOEA 2O3OA 2OOYA 2V8QA 3D4VA 4WZSD 1YQLA 4PY5A 2H4LX 3EIKA 4EAGA 2H5AX 2JHNA 2DKAA 1B9KA 2FGTA
chains in the Genus database with same CATH topology
1YQRA 1VOLB 1EBMA 2NOZA 1QN5A 2NOBA 2MJ7A 4I8OA 1E42A 1N3CA 2IV8A 1YTFA 3HS9A 1C9BB 4B0AA 1W80A 2VJ0A 2NOLA 1QTSA 2D0BA 5AN4A 1KO9A 1QNAA 2NOFA 1PZDA 1JFIC 1KY7A 1QNBA 1LWYA 1TGHA 1KY6A 2YH5A 1PCZA 3OSTA 4EJYA 1UT4A 3DPUA 2IV9A 2LAEA 1VOKA 5IYCP 3DPTA 2HZSA 3I0XA 4ROCB 4DULA 1QNCA 1M3HA 3N89A 2Z8UA 3F0ZA 1KYDA 3HS8A 1UT7A 2MZ8A 1R4XA 4RODB 1YQKA 2D0CA 1FN7A 1QN7A 2G30A 2HZMA 3OC3C 3KRMA 1TBAB 3OSMA 1NH2A 1N39A 2D0AA 3SNSA 1VTLE 5IYBP 1QN9A 4Q11A 1MP9A 4ROEB 1LWVA 3OCIA 2NOIA 1CDWA 1RM1A 1YTBA 2XHIA 1TBPA 1AISA 2I5WA 1KYFA 3I0WA 3VN5A 1D3UA 2NOHA 3ASMA 1NVPA 1QN4A 4TPSA 3KTUA 5IYDP 2JOIA 1QN6A 1N3AA 1QN8A 1HU0A 1KYUA 1NGMA 3ULXA 1YQMA 3H1ZA 1VTOA 3RPJA 3IH7A 1QN3A 3F10A 1LWWA 1QTPA 1M3QA 4EJZA 1QNEA 2NOEA 2O3OA 4WZSD 1YQLA 4PY5A 3EIKA 1B9KA 2FGTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Z8U A;  1KYF A;  1KYD A;  3VN5 A;  1D3U A;  1QNB A;  3ASM A;  3HS8 A;  1B9K A;  1NVP A;  1QN4 A;  1VOL B;  1R4X A;  1TGH A;  5IYD P;  1KY6 A;  4ROD B;  1QN5 A;  1PCZ A;  1QN6 A;  2D0C A;  1QN7 A;  1QN8 A;  2G30 A;  2MJ7 A;  1E42 A;  1KYU A;  2IV8 A;  1NGM A;  3OC3 C;  3H1Z A;  1TBA B;  1VTO A;  1YTF A;  1NH2 A;  3HS9 A;  1C9B B;  4B0A A;  2D0A A;  1QN3 A;  1W80 A;  2IV9 A;  1VOK A;  5IYC P;  1QTP A;  1QNC A;  1VTL E;  5IYB P;  1QN9 A;  2VJ0 A;  1QNE A;  1JFI C;  4WZS D;  1QTS A;  4PY5 A;  1MP9 A;  3EIK A;  2D0B A;  4ROE B;  4ROC B;  3OCI A;  1CDW A;  1QNA A;  1RM1 A;  1YTB A;  1TBP A;  1AIS A;  1PZD A;  1KY7 A; 
#chains in the Genus database with same CATH topology
 3OGD A;  2Y8Q A;  4EAL A;  1YQR A;  1VOL B;  1EBM A;  1Q9U A;  2QRD A;  1QN5 A;  1PCJ X;  2NOB A;  2NOZ A;  1KFQ A;  5EPC A;  2MJ7 A;  4I8O A;  1LXT A;  1PCM X;  1E42 A;  3ENO C;  2IV8 A;  1N3C A;  2NLV A;  1KFI A;  1UL7 A;  3UW2 A;  2YA3 A;  1YTF A;  3BKQ X;  3C04 A;  3HS9 A;  1C9B B;  4B0A A;  2F7L A;  4EAI A;  1W80 A;  2JPI A;  1JDY A;  2VJ0 A;  1C47 A;  1V5S A;  2NOL A;  2QRC A;  3ENC A;  1QTS A;  2D0B A;  5AN4 A;  1KO9 A;  1QNA A;  1TUO A;  2NOF A;  1PZD A;  1JFI C;  1KY7 A;  1EUV A;  2Z0F A;  1QNB A;  1MPG A;  2FKF A;  2QR1 A;  1LWY A;  3TDH A;  1KY6 A;  1TGH A;  2YH5 A;  2EHB D;  1PCZ A;  3OST A;  2DKD A;  2R5X A;  3CWT A;  4EJY A;  2PWW A;  1UT4 A;  5JMV D;  3CWU A;  3DPU A;  3CW7 A;  2IV9 A;  1T6A A;  2LAE A;  1VOK A;  1P5D X;  3NA5 A;  4MRQ A;  5IYC P;  1K35 A;  3DPT A;  2HL8 A;  4D7Q A;  2V9J A;  2FKM X;  2HZS A;  3I0X A;  5F9C A;  2NVM A;  4EAJ A;  4ROC B;  2QRE A;  3CVT A;  3EAY A;  3OLP A;  4DUL A;  1QNC A;  1M3H A;  3N89 A;  2Z8U A;  3F0Z A;  1KYD A;  3CWA A;  3HS8 A;  1UT7 A;  3T4N A;  2MZ8 A;  4IL8 A;  1R4X A;  4D7R A;  4ROD B;  1YQK A;  2D0C A;  1FN7 A;  1QN7 A;  2G30 A;  3PDK A;  2HZM A;  3OH6 A;  2FUV A;  3OC3 C;  2QLV A;  3KRM A;  1TBA B;  3OSM A;  1NH2 A;  1N39 A;  1J3M A;  3PMG A;  2D0A A;  3SNS A;  1C4G A;  2ZFD B;  1WJW A;  1XSZ A;  3OSE A;  1VTL E;  5IYB P;  4EAK A;  1QN9 A;  4WXA A;  1PVS A;  2JHJ A;  4Q11 A;  1DIZ A;  5JN5 A;  1K2Y X;  2DKC A;  1MP9 A;  4ROE B;  1LWV A;  3OCI A;  3RSM A;  1CDW A;  2NOI A;  4BJU A;  1RM1 A;  2Y8L A;  4QG5 A;  2HKP A;  1TBP A;  2XHI A;  1AIS A;  1YTB A;  2I5W A;  1KYF A;  5BMP A;  5KL0 A;  3VN5 A;  3I0W A;  2OOX A;  3ASM A;  1D3U A;  2V92 A;  2NOH A;  1NVP A;  4CFF A;  5HSH A;  1QN4 A;  4TPS A;  3KTU A;  5IYD P;  1P5G X;  2JOI A;  1QN6 A;  1N3A A;  1QN8 A;  2NWV A;  3D7Q A;  1HU0 A;  1KYU A;  1NGM A;  3ULX A;  3OH9 A;  3I3W A;  1WQA A;  3H1Z A;  4HJH A;  1YQM A;  4WX8 A;  1VTO A;  2HL9 A;  3RPJ A;  4C7P A;  3TE5 A;  3CWS A;  1VKL A;  3IH7 A;  1QN3 A;  3CVS A;  1M5Q 1;  3F10 A;  1LWW A;  5BMN A;  1QTP A;  1M3Q A;  4EJZ A;  1QNE A;  2NOE A;  2O3O A;  2OOY A;  2V8Q A;  3D4V A;  4WZS D;  1YQL A;  4PY5 A;  2H4L X;  3EIK A;  4EAG A;  2H5A X;  2JHN A;  2DKA A;  1B9K A;  2FGT A; 
#chains in the Genus database with same CATH homology
 1YQR A;  1VOL B;  1EBM A;  2NOZ A;  1QN5 A;  2NOB A;  2MJ7 A;  4I8O A;  1E42 A;  1N3C A;  2IV8 A;  1YTF A;  3HS9 A;  1C9B B;  4B0A A;  1W80 A;  2VJ0 A;  2NOL A;  1QTS A;  2D0B A;  5AN4 A;  1KO9 A;  1QNA A;  2NOF A;  1PZD A;  1JFI C;  1KY7 A;  1QNB A;  1LWY A;  1TGH A;  1KY6 A;  2YH5 A;  1PCZ A;  3OST A;  4EJY A;  1UT4 A;  3DPU A;  2IV9 A;  2LAE A;  1VOK A;  5IYC P;  3DPT A;  2HZS A;  3I0X A;  4ROC B;  4DUL A;  1QNC A;  1M3H A;  3N89 A;  2Z8U A;  3F0Z A;  1KYD A;  3HS8 A;  1UT7 A;  2MZ8 A;  1R4X A;  4ROD B;  1YQK A;  2D0C A;  1FN7 A;  1QN7 A;  2G30 A;  2HZM A;  3OC3 C;  3KRM A;  1TBA B;  3OSM A;  1NH2 A;  1N39 A;  2D0A A;  3SNS A;  1VTL E;  5IYB P;  1QN9 A;  4Q11 A;  1MP9 A;  4ROE B;  1LWV A;  3OCI A;  2NOI A;  1CDW A;  1RM1 A;  1YTB A;  2XHI A;  1TBP A;  1AIS A;  2I5W A;  1KYF A;  3I0W A;  3VN5 A;  1D3U A;  2NOH A;  3ASM A;  1NVP A;  1QN4 A;  4TPS A;  3KTU A;  5IYD P;  2JOI A;  1QN6 A;  1N3A A;  1QN8 A;  1HU0 A;  1KYU A;  1NGM A;  3ULX A;  1YQM A;  3H1Z A;  1VTO A;  3RPJ A;  3IH7 A;  1QN3 A;  3F10 A;  1LWW A;  1QTP A;  1M3Q A;  4EJZ A;  1QNE A;  2NOE A;  2O3O A;  4WZS D;  1YQL A;  4PY5 A;  3EIK A;  1B9K A;  2FGT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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