4PO2A

Crystal structure of the stress-inducible human heat shock protein hsp70 substrate-binding domain in complex with peptide substrate
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
228
structure length
228
Chain Sequence
ENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with Peptide substrate.
pubmed doi rcsb
molecule tags Chaperone
source organism Homo sapiens
molecule keywords Heat shock 70 kDa protein 1A/1B
total genus 71
structure length 228
sequence length 228
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-02-24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.10 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Substrate Binding Domain Of Dnak; Chain:A; Domain 2 4po2A02
2.60.34.10 Mainly Beta Sandwich Substrate Binding Domain Of DNAk; Chain A, domain 1 Substrate Binding Domain Of DNAk; Chain A, domain 1 4po2A01
1YUWA 4EZNA 4WV7A 4JNFA 4H6IA 3L3OM 3DPQA 4EZTA 4HY9A 3T4AG 4R5GA 4JNEA 3C7NB 7HSCA 4JWIA 1DKZA 3C7NA 4EZRA 2QFFA 4H6HA 4B9QA 4EZQA 1BPRA 4JN4A 3N8EA 3T47A 2BPRA 4HYBA 2OP6A 3T49A 3DQGA 4EZWA 4PO2A 4F01A 4E81A 4EZXA 4EZUA 3T46A 2KHOA 3DPOA 4EZPA 5TKYA 4EZYA 4WV5A 3H0XA 5E84A 4FL9A 4F00A 4R5JA 4EZVA 1DG4A 2V7YA 2WINM 4JWCA 4EZOA 1U00A 4R5IA 4JWEA 3D2EA 1DKXA 3QNJA 3T48A 3OHXM 4EZSA 1Q5LA 1DKYA 3DOBA 3D2FA 2QXLA 4EZZA 4R5KA 3DPPA 1CKRA 4JWDA 4R5LA
chains in the Genus database with same CATH superfamily
3RV1A 2JNKA 3OK8A 4I43A 1I49A 1GNTA 4R5GA 4M0MA 1I4TA 4EZQA 2OP6A 2LM0A 4F01A 3O3MB 1DKXA 3SOGA 1E9VA 3EJQA 4HY9A 2F7OA 4ILHB 4AZGA 2GA9D 4G6QA 3BUIA 4EZXA 4IM3A 4WV5A 2EX3B 3T48A 3D2FA 3M3WA 3FD9A 2WYIA 3PLTA 1TQWA 2O0I1 4JWIA 4JN4A 2X3VA 1TQTA 1E2UA 1MJGA 2KHOA 3SBTB 3VEAA 5FIGA 2EFLA 3DOBA 3D4ZA 2OO2A 2Z8YA 3Q84A 2F18A 1GN9A 4E3CA 1SUFA 4EZTA 4DCNC 1JQKA 2Q12A 1I4DA 2EFKA 4H6HA 3EJPA 2OBLA 1I4LA 3LMFA 4EZOA 4H8SA 1X03A 3HAHA 2ELBA 2YLAA 3CV5A 2MI7A 1LQ7A 1CKRA 3KAVA 4AZCB 4D8JA 4IM0A 4EZNA 4WV7A 4H6IA 2RAKA 1QX1A 3T4AG 3RV0A 1WDZA 3KAWA 3BVUA 4FZSA 4EZUA 3DPOA 2D4CA 3I39X 4AKVA 1OA1A 2F1AA 3UITA 2WYHA 1OA0A 1HTYA 4KIKB 1YUWA 3BLBA 2X5CA 5C5BB 1URUA 2N3KA 2RAJA 1DKZA 2OBMA 4AZ6A 4HYBA 4BNEA 3T49A 2OZNB 4DYLA 3BUPA 3B52X 1QWUA 2F7QA 3DX0A 3DDFA 1R5EA 3ZEFA 3DPPA 4AZ5A 1SU7A 4NSWA 3OWGA 3EJUA 2OW7A 4UDYX 4AZ7A 5E84A 1R33A 1U00A 4HR1A 2EWFA 3D50A 1OAOA 3L3PA 4IM2A 3CKDA 2RAIA 3ER8C 2OW6A 3O3NB 1TQSA 3EJSA 3GI7A 4WPCA 1TQVA 3N8EA 4B9QA 1ZWWA 4IWOA 3ZEDA 3VEBA 2ND1A 3D52A 3F7WA 1X04A 3O3OB 4ATMA 3H0XA 2PMRA 1PS3A 2F1BA 3OHXM 4AZBA 3QNIA 2FICA 3CZNA 2QFFA 4NQIA 4E81A 3KDRA 4EZYA 3ER9B 3B51X 1W9MA 1O7DB 3ERCC 1TQUA 1DKYA 3BUBA 2RT6A 3HAIA 3DPQA 2GF4A 2Z0OA 3DX1A 4JNEA 2V0OA 2BPRA 3DYTA 3SYVA 4AZIA 2YL6A 2YKTA 2Z0NA 2V7YA 2WINM 3D2EA 3CZSA 4EZSA 1Q5LA 3BVVA 3BVTA 5FLEX 4MQDA 2YIAA 3D51A 3I2WA 4PO2A 3VKHA 3QA8A 4IWPA 2YL9A 3HAJA 4AVMA 4IWQA 4EZZA 3SBSA 4JWDA 3DX2A 3A98A 3C7NB 2ND0A 4UDXX 4I1QA 3CAZA 2YI8A 5TKYA 2NCZA 4R5JA 1DG4A 5KBPA 1Y2OA 3QNJA 4JL9A 1SU6A 2YI9A 3ACOA 3I01A 4AZCA 3L3OM 2Q13A 2YIBA 7HSCA 3D4YA 1BPRA 1O7DC 4IW0A 2QKWA 3DQGA 2D1LA 4NPHA 3EJTA 1HWWA 2Z0VA 1SU8A 2X3XA 2YLLA 3DX3A 2C08A 3QE6A 3Q0KA 4ILGA 4ILIA 2F7RA 2YL8A 4R5KA 2ALWA 2PY6A 2YL5A 4JNFA 2LXYA 4KIKA 3CVRA 3LLLA 5C5BA 4FZPA 3G9GA 1GNLA 2JNSA 3DDGA 4FL9A 3ABHA 4F00A 4R5LA 3LVTA 3BUQA 3C7NA 2GAFD 3T47A 4FZOA 4AZHA 3BVXA 3BUDA 1E1DA 4HR1B 4EZVA 4FM3A 2F7PA 3RPMA 3DX4A 1UPXA 2ZXQA 3EJRA 1YWMA 1ZYLA 4EZRA 4JLCA 4EZWA 1QWNA 2X3WA 3BVWA 4EZPA 3T46A 1HXKA 3I04A 4WPEA 4JWCA 3B53X 4R5IA 2FYVA 2YIVX 4JWEA 1R34A 2QXLA 3QWEA
chains in the Genus database with same CATH topology
4IM0A 4EZNA 3I01A 4WV7A 4H6IA 3RV1A 3L3OM 4I43A 1GNTA 2YIBA 3T4AG 4R5GA 7HSCA 3RV0A 4M0MA 2QFFA 3KAWA 1BPRA 4EZQA 4IW0A 2OP6A 3DQGA 2LM0A 4F01A 4NPHA 4E81A 3KDRA 4EZUA 4EZYA 3DPOA 3ER9B 3O3MB 1SU8A 3B51X 1W9MA 3ERCC 3I39X 1DKXA 4ILGA 1DKYA 1OA1A 1E9VA 2RT6A 4ILIA 3UITA 4R5KA 1OA0A 2PY6A 4KIKB 1YUWA 4JNFA 4KIKA 3DPQA 2X5CA 4HY9A 2N3KA 4JNEA 1DKZA 2OBMA 4ILHB 2BPRA 4HYBA 2GA9D 4G6QA 3T49A 1GNLA 4EZXA 4IM3A 2JNSA 3B52X 4WV5A 4FL9A 4F00A 2V7YA 2WINM 3D2EA 2EX3B 3T48A 4EZSA 1Q5LA 3D2FA 5FLEX 3ZEFA 3DPPA 4R5LA 4MQDA 1SU7A 3FD9A 2YIAA 4JWIA 3OWGA 3C7NA 2GAFD 4JN4A 3T47A 4UDYX 4PO2A 1E2UA 3VKHA 1MJGA 2KHOA 3QA8A 4IWPA 5E84A 1E1DA 4HR1B 4EZVA 3SBTB 3VEAA 5FIGA 1U00A 4HR1A 2EWFA 4FM3A 3DOBA 4IWQA 2Z8YA 1OAOA 1UPXA 4IM2A 4EZZA 3SBSA 1GN9A 4E3CA 4JWDA 1SUFA 3ER8C 3O3NB 3A98A 4EZTA 1JQKA 3GI7A 3C7NB 1ZYLA 4EZRA 3N8EA 2ND0A 4H6HA 4B9QA 4UDXX 4IWOA 4JLCA 3ZEDA 2OBLA 4EZWA 3VEBA 2ND1A 3F7WA 3T46A 3O3OB 4EZPA 2YI8A 5TKYA 2NCZA 3H0XA 3I04A 3LMFA 4R5JA 1DG4A 4JWCA 4EZOA 3B53X 4R5IA 2YIVX 4JWEA 3QNJA 3OHXM 2QXLA 4JL9A 1SU6A 2YI9A 1CKRA 3KAVA 4D8JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YUW A;  4EZN A;  4WV7 A;  4JNF A;  4H6I A;  3L3O M;  3DPQ A;  4EZT A;  4HY9 A;  3T4A G;  4R5G A;  4JNE A;  3C7N B;  7HSC A;  4JWI A;  1DKZ A;  3C7N A;  4EZR A;  2QFF A;  4H6H A;  4B9Q A;  4EZQ A;  1BPR A;  4JN4 A;  3N8E A;  3T47 A;  2BPR A;  4HYB A;  2OP6 A;  3T49 A;  3DQG A;  4EZW A;  4PO2 A;  4F01 A;  4E81 A;  4EZX A;  4EZU A;  3T46 A;  2KHO A;  3DPO A;  4EZP A;  5TKY A;  4EZY A;  4WV5 A;  3H0X A;  5E84 A;  4FL9 A;  4F00 A;  4R5J A;  4EZV A;  1DG4 A;  2V7Y A;  2WIN M;  4JWC A;  4EZO A;  1U00 A;  4R5I A;  4JWE A;  3D2E A;  1DKX A;  3QNJ A;  3T48 A;  3OHX M;  4EZS A;  1Q5L A;  1DKY A;  3DOB A;  3D2F A;  2QXL A;  4EZZ A;  4R5K A;  3DPP A;  1CKR A;  4JWD A;  4R5L A; 
#chains in the Genus database with same CATH topology
 3RV1 A;  2JNK A;  3OK8 A;  4I43 A;  1I49 A;  1GNT A;  4R5G A;  4M0M A;  1I4T A;  4EZQ A;  2OP6 A;  2LM0 A;  4F01 A;  3O3M B;  1DKX A;  3SOG A;  1E9V A;  3EJQ A;  4HY9 A;  2F7O A;  4ILH B;  4AZG A;  2GA9 D;  4G6Q A;  3BUI A;  4EZX A;  4IM3 A;  4WV5 A;  2EX3 B;  3T48 A;  3D2F A;  3M3W A;  3FD9 A;  2WYI A;  3PLT A;  1TQW A;  2O0I 1;  4JWI A;  4JN4 A;  2X3V A;  1TQT A;  1E2U A;  1MJG A;  2KHO A;  3SBT B;  3VEA A;  5FIG A;  2EFL A;  3DOB A;  3D4Z A;  2OO2 A;  2Z8Y A;  3Q84 A;  2F18 A;  1GN9 A;  4E3C A;  1SUF A;  4EZT A;  4DCN C;  1JQK A;  2Q12 A;  1I4D A;  2EFK A;  4H6H A;  3EJP A;  2OBL A;  1I4L A;  3LMF A;  4EZO A;  4H8S A;  1X03 A;  3HAH A;  2ELB A;  2YLA A;  3CV5 A;  2MI7 A;  1LQ7 A;  1CKR A;  3KAV A;  4AZC B;  4D8J A;  4IM0 A;  4EZN A;  4WV7 A;  4H6I A;  2RAK A;  1QX1 A;  3T4A G;  3RV0 A;  1WDZ A;  3KAW A;  3BVU A;  4FZS A;  4EZU A;  3DPO A;  2D4C A;  3I39 X;  4AKV A;  1OA1 A;  2F1A A;  3UIT A;  2WYH A;  1OA0 A;  1HTY A;  4KIK B;  1YUW A;  3BLB A;  2X5C A;  5C5B B;  1URU A;  2N3K A;  2RAJ A;  1DKZ A;  2OBM A;  4AZ6 A;  4HYB A;  4BNE A;  3T49 A;  2OZN B;  4DYL A;  3BUP A;  3B52 X;  1QWU A;  2F7Q A;  3DX0 A;  3DDF A;  1R5E A;  3ZEF A;  3DPP A;  4AZ5 A;  1SU7 A;  4NSW A;  3OWG A;  3EJU A;  2OW7 A;  4UDY X;  4AZ7 A;  5E84 A;  1R33 A;  1U00 A;  4HR1 A;  2EWF A;  3D50 A;  1OAO A;  3L3P A;  4IM2 A;  3CKD A;  2RAI A;  3ER8 C;  2OW6 A;  3O3N B;  1TQS A;  3EJS A;  3GI7 A;  4WPC A;  1TQV A;  3N8E A;  4B9Q A;  1ZWW A;  4IWO A;  3ZED A;  3VEB A;  2ND1 A;  3D52 A;  3F7W A;  1X04 A;  3O3O B;  4ATM A;  3H0X A;  2PMR A;  1PS3 A;  2F1B A;  3OHX M;  4AZB A;  3QNI A;  2FIC A;  3CZN A;  2QFF A;  4NQI A;  4E81 A;  3KDR A;  4EZY A;  3ER9 B;  3B51 X;  1W9M A;  1O7D B;  3ERC C;  1TQU A;  1DKY A;  3BUB A;  2RT6 A;  3HAI A;  3DPQ A;  2GF4 A;  2Z0O A;  3DX1 A;  4JNE A;  2V0O A;  2BPR A;  3DYT A;  3SYV A;  4AZI A;  2YL6 A;  2YKT A;  2Z0N A;  2V7Y A;  2WIN M;  3D2E A;  3CZS A;  4EZS A;  1Q5L A;  3BVV A;  3BVT A;  5FLE X;  4MQD A;  2YIA A;  3D51 A;  3I2W A;  4PO2 A;  3VKH A;  3QA8 A;  4IWP A;  2YL9 A;  3HAJ A;  4AVM A;  4IWQ A;  4EZZ A;  3SBS A;  4JWD A;  3DX2 A;  3A98 A;  3C7N B;  2ND0 A;  4UDX X;  4I1Q A;  3CAZ A;  2YI8 A;  5TKY A;  2NCZ A;  4R5J A;  1DG4 A;  5KBP A;  1Y2O A;  3QNJ A;  4JL9 A;  1SU6 A;  2YI9 A;  3ACO A;  3I01 A;  4AZC A;  3L3O M;  2Q13 A;  2YIB A;  7HSC A;  3D4Y A;  1BPR A;  1O7D C;  4IW0 A;  2QKW A;  3DQG A;  2D1L A;  4NPH A;  3EJT A;  1HWW A;  2Z0V A;  1SU8 A;  2X3X A;  2YLL A;  3DX3 A;  2C08 A;  3QE6 A;  3Q0K A;  4ILG A;  4ILI A;  2F7R A;  2YL8 A;  4R5K A;  2ALW A;  2PY6 A;  2YL5 A;  4JNF A;  2LXY A;  4KIK A;  3CVR A;  3LLL A;  5C5B A;  4FZP A;  3G9G A;  1GNL A;  2JNS A;  3DDG A;  4FL9 A;  3ABH A;  4F00 A;  4R5L A;  3LVT A;  3BUQ A;  3C7N A;  2GAF D;  3T47 A;  4FZO A;  4AZH A;  3BVX A;  3BUD A;  1E1D A;  4HR1 B;  4EZV A;  4FM3 A;  2F7P A;  3RPM A;  3DX4 A;  1UPX A;  2ZXQ A;  3EJR A;  1YWM A;  1ZYL A;  4EZR A;  4JLC A;  4EZW A;  1QWN A;  2X3W A;  3BVW A;  4EZP A;  3T46 A;  1HXK A;  3I04 A;  4WPE A;  4JWC A;  3B53 X;  4R5I A;  2FYV A;  2YIV X;  4JWE A;  1R34 A;  2QXL A;  3QWE A; 
#chains in the Genus database with same CATH homology
 4IM0 A;  4EZN A;  3I01 A;  4WV7 A;  4H6I A;  3RV1 A;  3L3O M;  4I43 A;  1GNT A;  2YIB A;  3T4A G;  4R5G A;  7HSC A;  3RV0 A;  4M0M A;  2QFF A;  3KAW A;  1BPR A;  4EZQ A;  4IW0 A;  2OP6 A;  3DQG A;  2LM0 A;  4F01 A;  4NPH A;  4E81 A;  3KDR A;  4EZU A;  4EZY A;  3DPO A;  3ER9 B;  3O3M B;  1SU8 A;  3B51 X;  1W9M A;  3ERC C;  3I39 X;  1DKX A;  4ILG A;  1DKY A;  1OA1 A;  1E9V A;  2RT6 A;  4ILI A;  3UIT A;  4R5K A;  1OA0 A;  2PY6 A;  4KIK B;  1YUW A;  4JNF A;  4KIK A;  3DPQ A;  2X5C A;  4HY9 A;  2N3K A;  4JNE A;  1DKZ A;  2OBM A;  4ILH B;  2BPR A;  4HYB A;  2GA9 D;  4G6Q A;  3T49 A;  1GNL A;  4EZX A;  4IM3 A;  2JNS A;  3B52 X;  4WV5 A;  4FL9 A;  4F00 A;  2V7Y A;  2WIN M;  3D2E A;  2EX3 B;  3T48 A;  4EZS A;  1Q5L A;  3D2F A;  5FLE X;  3ZEF A;  3DPP A;  4R5L A;  4MQD A;  1SU7 A;  3FD9 A;  2YIA A;  4JWI A;  3OWG A;  3C7N A;  2GAF D;  4JN4 A;  3T47 A;  4UDY X;  4PO2 A;  1E2U A;  3VKH A;  1MJG A;  2KHO A;  3QA8 A;  4IWP A;  5E84 A;  1E1D A;  4HR1 B;  4EZV A;  3SBT B;  3VEA A;  5FIG A;  1U00 A;  4HR1 A;  2EWF A;  4FM3 A;  3DOB A;  4IWQ A;  2Z8Y A;  1OAO A;  1UPX A;  4IM2 A;  4EZZ A;  3SBS A;  1GN9 A;  4E3C A;  4JWD A;  1SUF A;  3ER8 C;  3O3N B;  3A98 A;  4EZT A;  1JQK A;  3GI7 A;  3C7N B;  1ZYL A;  4EZR A;  3N8E A;  2ND0 A;  4H6H A;  4B9Q A;  4UDX X;  4IWO A;  4JLC A;  3ZED A;  2OBL A;  4EZW A;  3VEB A;  2ND1 A;  3F7W A;  3T46 A;  3O3O B;  4EZP A;  2YI8 A;  5TKY A;  2NCZ A;  3H0X A;  3I04 A;  3LMF A;  4R5J A;  1DG4 A;  4JWC A;  4EZO A;  3B53 X;  4R5I A;  2YIV X;  4JWE A;  3QNJ A;  3OHX M;  2QXL A;  4JL9 A;  1SU6 A;  2YI9 A;  1CKR A;  3KAV A;  4D8J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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