4PO2A

Crystal structure of the stress-inducible human heat shock protein hsp70 substrate-binding domain in complex with peptide substrate
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
228
structure length
228
Chain Sequence
ENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Chaperone
source organism Homo sapiens
publication title Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with Peptide substrate.
pubmed doi rcsb
molecule keywords Heat shock 70 kDa protein 1A/1B
total genus 71
structure length 228
sequence length 228
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-02-24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.10 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Substrate Binding Domain Of Dnak; Chain:A; Domain 2 4po2A02
2.60.34.10 Mainly Beta Sandwich Substrate Binding Domain Of DNAk; Chain A, domain 1 Substrate Binding Domain Of DNAk; Chain A, domain 1 4po2A01
7HSCA 1DG4A 3T4AG 4EZNA 4EZYA 1DKXA 4E81A 4EZWA 1U00A 3D2FA 5TKYA 4F00A 4JWIA 2OP6A 4JWEA 2QXLA 4EZSA 4R5LA 4EZXA 4EZZA 3OHXM 4R5KA 4B9QA 4H6IA 4R5GA 3N8EA 4HYBA 4JN4A 2BPRA 4JNFA 4HY9A 3DPQA 1YUWA 1CKRA 3C7NA 3DQGA 4EZRA 4WV7A 3QNJA 5E84A 2KHOA 2WINM 3DPPA 1DKZA 3DPOA 3T47A 4JWDA 4EZVA 4H6HA 3DOBA 1DKYA 4FL9A 4EZPA 3H0XA 4WV5A 4EZTA 3L3OM 4JNEA 4R5JA 2V7YA 1Q5LA 4EZQA 4EZUA 3D2EA 3T48A 2QFFA 3T49A 4EZOA 4F01A 4JWCA 1BPRA 4R5IA 3C7NB 4PO2A 3T46A
chains in the Genus database with same CATH superfamily
3CV5A 4JWEA 1CKRA 4FZOA 3QNJA 3L3PA 1TQSA 3T47A 4FZSA 4AZBA 2YLLA 3EJSA 4R5JA 3BVWA 4NSWA 3ACOA 4FM3A 3KAWA 3D4ZA 1O7DB 3CKDA 3BUDA 3ERCC 4AZCB 2QKWA 3EJUA 1ZYLA 3DX4A 1OA1A 2EWFA 2NCZA 4HYBA 3DPQA 3DX3A 3BLBA 2KHOA 3OWGA 4AZ5A 3I2WA 3DOBA 3QWEA 4AZ6A 2YIAA 4WV5A 2PMRA 3SYVA 3ZEDA 3G9GA 2OZNB 5TKYA 3ER8C 4B9QA 2EX3B 1WDZA 4ILHB 2F7PA 2JNKA 1W9MA 2Z0OA 3DDFA 2RAKA 3T49A 1SUFA 4UDXX 1GNTA 3B52X 2OBMA 2ELBA 4KIKB 2O0I1 4WPCA 3EJRA 1HTYA 4H8SA 3ABHA 3QA8A 2LM0A 1YWMA 3CZNA 2YI9A 4G6QA 2C08A 3PLTA 4EZUA 4EZOA 3SBTB 4EZZA 4WPEA 1SU8A 2YI8A 3FD9A 1QWUA 3ZEFA 2OW6A 4E81A 2F1BA 4IM0A 4R5LA 3F7WA 3Q0KA 4AZCA 3DYTA 3LLLA 2OW7A 4EZQA 3D2EA 4DCNC 2ZXQA 4JWCA 2V7YA 3O3NB 3QNIA 3T46A 1X03A 3O3OB 2QXLA 4H6IA 2EFLA 3EJQA 2X3WA 1R34A 1DKZA 4FL9A 1GN9A 3O3MB 4ILIA 2JNSA 4MQDA 3DX2A 3LMFA 3A98A 2YIBA 1URUA 4JWIA 4AVMA 4EZXA 3B51X 4M0MA 3HAJA 3D50A 1I49A 4IWOA 4KIKA 3I04A 4EZTA 2Q13A 1PS3A 1TQTA 4FZPA 2GA9D 2ND1A 3RV1A 2YKTA 3SOGA 2YL9A 2OP6A 4E3CA 4AZHA 3BUQA 1TQUA 2Q12A 2D4CA 1X04A 1YUWA 3Q84A 1I4LA 3UITA 4AZIA 2YIVX 2RAIA 3EJPA 4F01A 1TQVA 3RPMA 4IM2A 4IWQA 3BVUA 4JNFA 3BVTA 1Y2OA 4EZVA 3H0XA 3L3OM 4ATMA 4JL9A 1SU6A 3T4AG 1JQKA 1OAOA 3CAZA 3D2FA 2LXYA 3KAVA 4WV7A 3BVXA 3D52A 2YL5A 4H6HA 4IW0A 1MJGA 1UPXA 2QFFA 4I1QA 3OK8A 4NPHA 4EZNA 4JLCA 4F00A 4ILGA 2BPRA 4JN4A 3EJTA 3DQGA 4UDYX 2WINM 5KBPA 5C5BB 1E1DA 4AZ7A 4EZPA 3GI7A 4BNEA 3C7NB 2YL6A 3I39X 1QX1A 4HR1A 1HWWA 3N8EA 2RT6A 3BUBA 1HXKA 3BUIA 4EZRA 3DPPA 1SU7A 1LQ7A 4PO2A 3D51A 1DG4A 1GNLA 4EZYA 2X5CA 1I4TA 2PY6A 2F1AA 3OHXM 4R5GA 2ALWA 4HY9A 2YLAA 1O7DC 1E9VA 2D1LA 3DPOA 1I4DA 2OO2A 4HR1B 3ER9B 3RV0A 2GF4A 1QWNA 1BPRA 1Q5LA 2F18A 2OBLA 1OA0A 3LVTA 4IWPA 3CZSA 3HAIA 3HAHA 2X3XA 3DX1A 2X3VA 3VKHA 3DDGA 7HSCA 1DKXA 3M3WA 2GAFD 5FIGA 5C5BA 3B53X 4IM3A 4EZSA 4R5KA 3KDRA 3C7NA 4NQIA 2RAJA 5E84A 4I43A 2WYHA 1DKYA 2V0OA 4AKVA 2Z8YA 4JNEA 2N3KA 3T48A 3BUPA 2F7RA 2Z0VA 1R5EA 2F7QA 3SBSA 2FYVA 3QE6A 2F7OA 4EZWA 2ND0A 1U00A 1R33A 2FICA 1E2UA 3D4YA 2EFKA 4DYLA 5FLEX 1ZWWA 4AZGA 3VEAA 3BVVA 4D8JA 3DX0A 2WYIA 4JWDA 3VEBA 1TQWA 2YL8A 2MI7A 3I01A 2Z0NA 3CVRA 4R5IA
chains in the Genus database with same CATH topology
1SU8A 2YI8A 3FD9A 3ZEFA 1GNLA 4EZYA 1DG4A 2X5CA 4E81A 2PY6A 4JWEA 4IM0A 4R5LA 4IM2A 3F7WA 4IWQA 4EZZA 3OHXM 4R5GA 4JNFA 4HY9A 1CKRA 3QNJA 1E9VA 3DPOA 3T47A 4EZVA 4HR1B 3H0XA 3L3OM 3ER9B 4R5JA 4EZQA 4FM3A 4JL9A 3KAWA 3D2EA 3RV0A 1BPRA 4JWCA 2V7YA 3O3NB 1SU6A 1Q5LA 3T46A 3ERCC 3T4AG 1JQKA 3O3OB 1OAOA 1ZYLA 2OBLA 3D2FA 2QXLA 1OA1A 1OA0A 2EWFA 2NCZA 4H6IA 4IWPA 4HYBA 3KAVA 3DPQA 4WV7A 2KHOA 3OWGA 1DKZA 4H6HA 4IW0A 3DOBA 4FL9A 1GN9A 1MJGA 2YIAA 3VKHA 1UPXA 2QFFA 3O3MB 4ILIA 4WV5A 2JNSA 4MQDA 3LMFA 3ZEDA 7HSCA 4NPHA 3A98A 4EZNA 1DKXA 2GAFD 2YIBA 5FIGA 5TKYA 3B53X 4IM3A 4JWIA 4JLCA 4F00A 4EZSA 4EZXA 4ILGA 3ER8C 4R5KA 4B9QA 3B51X 2BPRA 4JN4A 4M0MA 3KDRA 2EX3B 3C7NA 3DQGA 4UDYX 5E84A 2WINM 4ILHB 4I43A 1W9MA 4IWOA 4KIKA 1DKYA 3I04A 1E1DA 4EZPA 4EZTA 2Z8YA 4JNEA 3GI7A 2GA9D 2N3KA 2ND1A 1SUFA 3T48A 4UDXX 1GNTA 3T49A 3B52X 3C7NB 3RV1A 2OBMA 3SBSA 3I39X 4KIKB 4HR1A 4EZWA 2ND0A 1U00A 2OP6A 1E2UA 4E3CA 5FLEX 3N8EA 3VEAA 4D8JA 2RT6A 1YUWA 4EZRA 3UITA 3QA8A 3DPPA 2LM0A 1SU7A 2YIVX 4JWDA 3VEBA 2YI9A 4G6QA 3I01A 4EZUA 4EZOA 3SBTB 4F01A 4R5IA 4PO2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 7HSC A;  1DG4 A;  3T4A G;  4EZN A;  4EZY A;  1DKX A;  4E81 A;  4EZW A;  1U00 A;  3D2F A;  5TKY A;  4F00 A;  4JWI A;  2OP6 A;  4JWE A;  2QXL A;  4EZS A;  4R5L A;  4EZX A;  4EZZ A;  3OHX M;  4R5K A;  4B9Q A;  4H6I A;  4R5G A;  3N8E A;  4HYB A;  4JN4 A;  2BPR A;  4JNF A;  4HY9 A;  3DPQ A;  1YUW A;  1CKR A;  3C7N A;  3DQG A;  4EZR A;  4WV7 A;  3QNJ A;  5E84 A;  2KHO A;  2WIN M;  3DPP A;  1DKZ A;  3DPO A;  3T47 A;  4JWD A;  4EZV A;  4H6H A;  3DOB A;  1DKY A;  4FL9 A;  4EZP A;  3H0X A;  4WV5 A;  4EZT A;  3L3O M;  4JNE A;  4R5J A;  2V7Y A;  1Q5L A;  4EZQ A;  4EZU A;  3D2E A;  3T48 A;  2QFF A;  3T49 A;  4EZO A;  4F01 A;  4JWC A;  1BPR A;  4R5I A;  3C7N B;  4PO2 A;  3T46 A; 
#chains in the Genus database with same CATH topology
 3CV5 A;  4JWE A;  1CKR A;  4FZO A;  3QNJ A;  3L3P A;  1TQS A;  3T47 A;  4FZS A;  4AZB A;  2YLL A;  3EJS A;  4R5J A;  3BVW A;  4NSW A;  3ACO A;  4FM3 A;  3KAW A;  3D4Z A;  1O7D B;  3CKD A;  3BUD A;  3ERC C;  4AZC B;  2QKW A;  3EJU A;  1ZYL A;  3DX4 A;  1OA1 A;  2EWF A;  2NCZ A;  4HYB A;  3DPQ A;  3DX3 A;  3BLB A;  2KHO A;  3OWG A;  4AZ5 A;  3I2W A;  3DOB A;  3QWE A;  4AZ6 A;  2YIA A;  4WV5 A;  2PMR A;  3SYV A;  3ZED A;  3G9G A;  2OZN B;  5TKY A;  3ER8 C;  4B9Q A;  2EX3 B;  1WDZ A;  4ILH B;  2F7P A;  2JNK A;  1W9M A;  2Z0O A;  3DDF A;  2RAK A;  3T49 A;  1SUF A;  4UDX X;  1GNT A;  3B52 X;  2OBM A;  2ELB A;  4KIK B;  2O0I 1;  4WPC A;  3EJR A;  1HTY A;  4H8S A;  3ABH A;  3QA8 A;  2LM0 A;  1YWM A;  3CZN A;  2YI9 A;  4G6Q A;  2C08 A;  3PLT A;  4EZU A;  4EZO A;  3SBT B;  4EZZ A;  4WPE A;  1SU8 A;  2YI8 A;  3FD9 A;  1QWU A;  3ZEF A;  2OW6 A;  4E81 A;  2F1B A;  4IM0 A;  4R5L A;  3F7W A;  3Q0K A;  4AZC A;  3DYT A;  3LLL A;  2OW7 A;  4EZQ A;  3D2E A;  4DCN C;  2ZXQ A;  4JWC A;  2V7Y A;  3O3N B;  3QNI A;  3T46 A;  1X03 A;  3O3O B;  2QXL A;  4H6I A;  2EFL A;  3EJQ A;  2X3W A;  1R34 A;  1DKZ A;  4FL9 A;  1GN9 A;  3O3M B;  4ILI A;  2JNS A;  4MQD A;  3DX2 A;  3LMF A;  3A98 A;  2YIB A;  1URU A;  4JWI A;  4AVM A;  4EZX A;  3B51 X;  4M0M A;  3HAJ A;  3D50 A;  1I49 A;  4IWO A;  4KIK A;  3I04 A;  4EZT A;  2Q13 A;  1PS3 A;  1TQT A;  4FZP A;  2GA9 D;  2ND1 A;  3RV1 A;  2YKT A;  3SOG A;  2YL9 A;  2OP6 A;  4E3C A;  4AZH A;  3BUQ A;  1TQU A;  2Q12 A;  2D4C A;  1X04 A;  1YUW A;  3Q84 A;  1I4L A;  3UIT A;  4AZI A;  2YIV X;  2RAI A;  3EJP A;  4F01 A;  1TQV A;  3RPM A;  4IM2 A;  4IWQ A;  3BVU A;  4JNF A;  3BVT A;  1Y2O A;  4EZV A;  3H0X A;  3L3O M;  4ATM A;  4JL9 A;  1SU6 A;  3T4A G;  1JQK A;  1OAO A;  3CAZ A;  3D2F A;  2LXY A;  3KAV A;  4WV7 A;  3BVX A;  3D52 A;  2YL5 A;  4H6H A;  4IW0 A;  1MJG A;  1UPX A;  2QFF A;  4I1Q A;  3OK8 A;  4NPH A;  4EZN A;  4JLC A;  4F00 A;  4ILG A;  2BPR A;  4JN4 A;  3EJT A;  3DQG A;  4UDY X;  2WIN M;  5KBP A;  5C5B B;  1E1D A;  4AZ7 A;  4EZP A;  3GI7 A;  4BNE A;  3C7N B;  2YL6 A;  3I39 X;  1QX1 A;  4HR1 A;  1HWW A;  3N8E A;  2RT6 A;  3BUB A;  1HXK A;  3BUI A;  4EZR A;  3DPP A;  1SU7 A;  1LQ7 A;  4PO2 A;  3D51 A;  1DG4 A;  1GNL A;  4EZY A;  2X5C A;  1I4T A;  2PY6 A;  2F1A A;  3OHX M;  4R5G A;  2ALW A;  4HY9 A;  2YLA A;  1O7D C;  1E9V A;  2D1L A;  3DPO A;  1I4D A;  2OO2 A;  4HR1 B;  3ER9 B;  3RV0 A;  2GF4 A;  1QWN A;  1BPR A;  1Q5L A;  2F18 A;  2OBL A;  1OA0 A;  3LVT A;  4IWP A;  3CZS A;  3HAI A;  3HAH A;  2X3X A;  3DX1 A;  2X3V A;  3VKH A;  3DDG A;  7HSC A;  1DKX A;  3M3W A;  2GAF D;  5FIG A;  5C5B A;  3B53 X;  4IM3 A;  4EZS A;  4R5K A;  3KDR A;  3C7N A;  4NQI A;  2RAJ A;  5E84 A;  4I43 A;  2WYH A;  1DKY A;  2V0O A;  4AKV A;  2Z8Y A;  4JNE A;  2N3K A;  3T48 A;  3BUP A;  2F7R A;  2Z0V A;  1R5E A;  2F7Q A;  3SBS A;  2FYV A;  3QE6 A;  2F7O A;  4EZW A;  2ND0 A;  1U00 A;  1R33 A;  2FIC A;  1E2U A;  3D4Y A;  2EFK A;  4DYL A;  5FLE X;  1ZWW A;  4AZG A;  3VEA A;  3BVV A;  4D8J A;  3DX0 A;  2WYI A;  4JWD A;  3VEB A;  1TQW A;  2YL8 A;  2MI7 A;  3I01 A;  2Z0N A;  3CVR A;  4R5I A; 
#chains in the Genus database with same CATH homology
 1SU8 A;  2YI8 A;  3FD9 A;  3ZEF A;  1GNL A;  4EZY A;  1DG4 A;  2X5C A;  4E81 A;  2PY6 A;  4JWE A;  4IM0 A;  4R5L A;  4IM2 A;  3F7W A;  4IWQ A;  4EZZ A;  3OHX M;  4R5G A;  4JNF A;  4HY9 A;  1CKR A;  3QNJ A;  1E9V A;  3DPO A;  3T47 A;  4EZV A;  4HR1 B;  3H0X A;  3L3O M;  3ER9 B;  4R5J A;  4EZQ A;  4FM3 A;  4JL9 A;  3KAW A;  3D2E A;  3RV0 A;  1BPR A;  4JWC A;  2V7Y A;  3O3N B;  1SU6 A;  1Q5L A;  3T46 A;  3ERC C;  3T4A G;  1JQK A;  3O3O B;  1OAO A;  1ZYL A;  2OBL A;  3D2F A;  2QXL A;  1OA1 A;  1OA0 A;  2EWF A;  2NCZ A;  4H6I A;  4IWP A;  4HYB A;  3KAV A;  3DPQ A;  4WV7 A;  2KHO A;  3OWG A;  1DKZ A;  4H6H A;  4IW0 A;  3DOB A;  4FL9 A;  1GN9 A;  1MJG A;  2YIA A;  3VKH A;  1UPX A;  2QFF A;  3O3M B;  4ILI A;  4WV5 A;  2JNS A;  4MQD A;  3LMF A;  3ZED A;  7HSC A;  4NPH A;  3A98 A;  4EZN A;  1DKX A;  2GAF D;  2YIB A;  5FIG A;  5TKY A;  3B53 X;  4IM3 A;  4JWI A;  4JLC A;  4F00 A;  4EZS A;  4EZX A;  4ILG A;  3ER8 C;  4R5K A;  4B9Q A;  3B51 X;  2BPR A;  4JN4 A;  4M0M A;  3KDR A;  2EX3 B;  3C7N A;  3DQG A;  4UDY X;  5E84 A;  2WIN M;  4ILH B;  4I43 A;  1W9M A;  4IWO A;  4KIK A;  1DKY A;  3I04 A;  1E1D A;  4EZP A;  4EZT A;  2Z8Y A;  4JNE A;  3GI7 A;  2GA9 D;  2N3K A;  2ND1 A;  1SUF A;  3T48 A;  4UDX X;  1GNT A;  3T49 A;  3B52 X;  3C7N B;  3RV1 A;  2OBM A;  3SBS A;  3I39 X;  4KIK B;  4HR1 A;  4EZW A;  2ND0 A;  1U00 A;  2OP6 A;  1E2U A;  4E3C A;  5FLE X;  3N8E A;  3VEA A;  4D8J A;  2RT6 A;  1YUW A;  4EZR A;  3UIT A;  3QA8 A;  3DPP A;  2LM0 A;  1SU7 A;  2YIV X;  4JWD A;  3VEB A;  2YI9 A;  4G6Q A;  3I01 A;  4EZU A;  4EZO A;  3SBT B;  4F01 A;  4R5I A;  4PO2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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