5F9C | Genus

Total Genus 176

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	176
sequence length	562
structure length	550
Chain Sequence	MVKIVTVKTQAYQDQKPGTSGLRKRVKVFQSSANYAENFIQSIISTVEPAQRQEATLVVGGDGRFYMKEAIQLIARIAAANGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTASHNPRGPNGDFGIKFNISNGGPAPEAITDKIFQISKTIEEYAVCPDLKVDLGVLGKQQFDLENKFKPFTVEIVDSVEAYATMLRSIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKILCEELGAPANSAVNCVPLEDFNLTYAADLVETMKSGEHDFGAAFDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMPTSGALDRVASATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGATIRLYIDSYEKDVAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTVIT

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 550 atoms

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Isomerase
source organism	Homo sapiens
publication title	Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency. pubmed doi rcsb
molecule keywords	Phosphoglucomutase-1
total genus	176
structure length	550
sequence length	562
chains with identical sequence	B
ec nomenclature	ec 5.4.2.2: Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
pdb deposition date	2015-12-09

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00408	PGM_PMM_IV	Phosphoglucomutase/phosphomannomutase, C-terminal domain
A	PF02878	PGM_PMM_I	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
A	PF02879	PGM_PMM_II	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
A	PF02880	PGM_PMM_III	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.30.310.50	Alpha Beta	2-Layer Sandwich	TATA-Binding Protein	Alpha-D-phosphohexomutase, C-terminal domain	5f9cA04
3.40.120.10	Alpha Beta	3-Layer(aba) Sandwich	Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3	Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3	5f9cA02
3.40.120.10	Alpha Beta	3-Layer(aba) Sandwich	Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3	Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3	5f9cA03
3.40.120.10	Alpha Beta	3-Layer(aba) Sandwich	Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3	Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3	5f9cA01

2JPIA 3ENOC 4QG5A 5KL0A 3BKQX 4BJUA 2DKCA 5BMPA 1VKLA 4WXAA 5BMNA 1WJWA 1PCJX 1P5DX 3OLPA 2Z0FA 4IL8A 5F9CA 3PDKA 4MRQA 3I3WA 3RSMA 3UW2A 1P5GX 1WQAA 1C4GA 2FKFA 3NA5A 5JMVD 2EHPA 1LXTA 5EPCA 2H4LX 4WX8A 1PCMX 2H5AX 1C47A 5HSHA 2FKMX 1KFQA 1TUOA 3ENCA 2FUVA 2F7LA 4HJHA 1K2YX 2DKAA 1K35A 3PMGA 5JN5A 1JDYA 2EIUA 2DKDA 1KFIA 3C04A
chains in the Genus database with same CATH superfamily

2JPIA 1PVSA 2O3OA 2V8QA 3HS9A 5KL0A 2D0BA 2Z8UA 3OGDA 1W80A 3BKQX 2LAEA 4BJUA 2JHJA 2FGTA 4DULA 1QN5A 1KYDA 2NOIA 3D7QA 5IYCP 5BMNA 1WJWA 1PCJX 3PDKA 2HKPA 3I3WA 2PWWA 2QLVA 4ROEB 3OSTA 1N39A 2NOZA 1UL7A 3CW7A 1HU0A 2D0AA 1KYUA 2I5WA 2IV8A 5EPCA 2HL8A 2QRDA 4WX8A 3SNSA 3DPUA 3RPJA 2H5AX 1C47A 1M5Q1 2QR1A 3CWTA 2OOYA 1VTLE 2R5XA 2YH5A 2MZ8A 1E42A 1VOKA 3PMGA 2MJ7A 2DKDA 1R4XA 1V5SA 3OH9A 3ULXA 3H1ZA 4EALA 2DKCA 2NOLA 4WXAA 2D0CA 1VTOA 1P5DX 2G30A 5F9CA 1UT7A 2ZFDB 4RODB 3D4VA 2JHNA 4CFFA 1NGMA 2VJ0A 1XSZA 1QNCA 2NOFA 3CVSA 1N3CA 3OSEA 2FKFA 1TBAB 2V92A 2V9JA 5IYDP 4EJYA 4B0AA 1YTFA 2HL9A 1QTPA 2H4LX 1PZDA 4EAIA 3OCIA 4EAKA 1C9BB 2FKMX 2NVMA 1KFQA 3ENCA 3TE5A 1QN9A 3EAYA 2Y8QA 2EHBD 3C04A 3OC3C 1MP9A 3CWSA 2IV9A 5AN4A 3OH6A 1J3MA 1VKLA 2XHIA 3KRMA 2NOHA 4PY5A 1RM1A 1YQLA 4MRQA 1QNBA 1N3AA 1FN7A 3UW2A 5IYBP 1P5GX 1WQAA 4C7PA 3CWUA 1C4GA 1UT4A 5JMVD 1JFIC 1QN3A 4EJZA 2EHPA 4D7QA 1EBMA 1LXTA 1M3QA 2NOBA 3TDHA 3F0ZA 1NH2A 1D3UA 1QN8A 3DPTA 1LWYA 1KO9A 1PCMX 2HZMA 2HZSA 1MPGA 1QNEA 1YQKA 1YQMA 2YA3A 1CDWA 1LWWA 1TUOA 3F10A 2FUVA 3N89A 4HJHA 1NVPA 1QN4A 2DKAA 4EAGA 1QNAA 1YTBA 1KY7A 3I0XA 1JDYA 4TPSA 3KTUA 1QN7A 2EIUA 3VN5A 1YQRA 3ENOC 1PCZA 1Q9UA 1EUVA 2QRCA 5BMPA 1LWVA 4I8OA 3OLPA 3CVTA 2Z0FA 4IL8A 1VOLB 1AISA 1TGHA 4Q11A 1DIZA 3RSMA 3NA5A 3HS8A 1T6AA 2OOXA 1QTSA 3IH7A 3I0WA 2NWVA 1KYFA 2JOIA 1KY6A 2QREA 3T4NA 4EAJA 3OSMA 3CWAA 5HSHA 1QN6A 2NOEA 4WZSD 2F7LA 2NLVA 1K2YX 1K35A 2Y8LA 1B9KA 5JN5A 1TBPA 3EIKA 1M3HA 4QG5A 1KFIA 3ASMA 4D7RA 4ROCB
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2JPI A;  3ENO C;  4QG5 A;  5KL0 A;  3BKQ X;  4BJU A;  2DKC A;  5BMP A;  1VKL A;  4WXA A;  5BMN A;  1WJW A;  1PCJ X;  1P5D X;  3OLP A;  2Z0F A;  4IL8 A;  5F9C A;  3PDK A;  4MRQ A;  3I3W A;  3RSM A;  3UW2 A;  1P5G X;  1WQA A;  1C4G A;  2FKF A;  3NA5 A;  5JMV D;  2EHP A;  1LXT A;  5EPC A;  2H4L X;  4WX8 A;  1PCM X;  2H5A X;  1C47 A;  5HSH A;  2FKM X;  1KFQ A;  1TUO A;  3ENC A;  2FUV A;  2F7L A;  4HJH A;  1K2Y X;  2DKA A;  1K35 A;  3PMG A;  5JN5 A;  1JDY A;  2EIU A;  2DKD A;  1KFI A;  3C04 A; 
#chains in the Genus database with same CATH topology
 2JPI A;  1PVS A;  2O3O A;  2V8Q A;  3HS9 A;  5KL0 A;  2D0B A;  2Z8U A;  3OGD A;  1W80 A;  3BKQ X;  2LAE A;  4BJU A;  2JHJ A;  2FGT A;  4DUL A;  1QN5 A;  1KYD A;  2NOI A;  3D7Q A;  5IYC P;  5BMN A;  1WJW A;  1PCJ X;  3PDK A;  2HKP A;  3I3W A;  2PWW A;  2QLV A;  4ROE B;  3OST A;  1N39 A;  2NOZ A;  1UL7 A;  3CW7 A;  1HU0 A;  2D0A A;  1KYU A;  2I5W A;  2IV8 A;  5EPC A;  2HL8 A;  2QRD A;  4WX8 A;  3SNS A;  3DPU A;  3RPJ A;  2H5A X;  1C47 A;  1M5Q 1;  2QR1 A;  3CWT A;  2OOY A;  1VTL E;  2R5X A;  2YH5 A;  2MZ8 A;  1E42 A;  1VOK A;  3PMG A;  2MJ7 A;  2DKD A;  1R4X A;  1V5S A;  3OH9 A;  3ULX A;  3H1Z A;  4EAL A;  2DKC A;  2NOL A;  4WXA A;  2D0C A;  1VTO A;  1P5D X;  2G30 A;  5F9C A;  1UT7 A;  2ZFD B;  4ROD B;  3D4V A;  2JHN A;  4CFF A;  1NGM A;  2VJ0 A;  1XSZ A;  1QNC A;  2NOF A;  3CVS A;  1N3C A;  3OSE A;  2FKF A;  1TBA B;  2V92 A;  2V9J A;  5IYD P;  4EJY A;  4B0A A;  1YTF A;  2HL9 A;  1QTP A;  2H4L X;  1PZD A;  4EAI A;  3OCI A;  4EAK A;  1C9B B;  2FKM X;  2NVM A;  1KFQ A;  3ENC A;  3TE5 A;  1QN9 A;  3EAY A;  2Y8Q A;  2EHB D;  3C04 A;  3OC3 C;  1MP9 A;  3CWS A;  2IV9 A;  5AN4 A;  3OH6 A;  1J3M A;  1VKL A;  2XHI A;  3KRM A;  2NOH A;  4PY5 A;  1RM1 A;  1YQL A;  4MRQ A;  1QNB A;  1N3A A;  1FN7 A;  3UW2 A;  5IYB P;  1P5G X;  1WQA A;  4C7P A;  3CWU A;  1C4G A;  1UT4 A;  5JMV D;  1JFI C;  1QN3 A;  4EJZ A;  2EHP A;  4D7Q A;  1EBM A;  1LXT A;  1M3Q A;  2NOB A;  3TDH A;  3F0Z A;  1NH2 A;  1D3U A;  1QN8 A;  3DPT A;  1LWY A;  1KO9 A;  1PCM X;  2HZM A;  2HZS A;  1MPG A;  1QNE A;  1YQK A;  1YQM A;  2YA3 A;  1CDW A;  1LWW A;  1TUO A;  3F10 A;  2FUV A;  3N89 A;  4HJH A;  1NVP A;  1QN4 A;  2DKA A;  4EAG A;  1QNA A;  1YTB A;  1KY7 A;  3I0X A;  1JDY A;  4TPS A;  3KTU A;  1QN7 A;  2EIU A;  3VN5 A;  1YQR A;  3ENO C;  1PCZ A;  1Q9U A;  1EUV A;  2QRC A;  5BMP A;  1LWV A;  4I8O A;  3OLP A;  3CVT A;  2Z0F A;  4IL8 A;  1VOL B;  1AIS A;  1TGH A;  4Q11 A;  1DIZ A;  3RSM A;  3NA5 A;  3HS8 A;  1T6A A;  2OOX A;  1QTS A;  3IH7 A;  3I0W A;  2NWV A;  1KYF A;  2JOI A;  1KY6 A;  2QRE A;  3T4N A;  4EAJ A;  3OSM A;  3CWA A;  5HSH A;  1QN6 A;  2NOE A;  4WZS D;  2F7L A;  2NLV A;  1K2Y X;  1K35 A;  2Y8L A;  1B9K A;  5JN5 A;  1TBP A;  3EIK A;  1M3H A;  4QG5 A;  1KFI A;  3ASM A;  4D7R A;  4ROC B; 
#chains in the Genus database with same CATH homology
 2JPI A;  3ENO C;  4QG5 A;  5KL0 A;  3BKQ X;  4BJU A;  2DKC A;  5BMP A;  1VKL A;  4WXA A;  5BMN A;  1WJW A;  1PCJ X;  1P5D X;  3OLP A;  2Z0F A;  4IL8 A;  5F9C A;  3PDK A;  4MRQ A;  3I3W A;  3RSM A;  3UW2 A;  1P5G X;  1WQA A;  1C4G A;  2FKF A;  3NA5 A;  5JMV D;  2EHP A;  1LXT A;  5EPC A;  2H4L X;  4WX8 A;  1PCM X;  2H5A X;  1C47 A;  5HSH A;  2FKM X;  1KFQ A;  1TUO A;  3ENC A;  2FUV A;  2F7L A;  4HJH A;  1K2Y X;  2DKA A;  1K35 A;  3PMG A;  5JN5 A;  1JDY A;  2EIU A;  2DKD A;  1KFI A;  3C04 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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5F9CA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations