The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
73
|
sequence length |
304
|
structure length |
275
|
Chain Sequence |
NKRMNERELVELETAYPEQVLADSPTHRVGGKVLDGFEKYSHQYPLYSLQDAFSREELDAFDARVRKEVAHPTYICELKIDGLSISLTYEKGILVAGVTRGDGSIGENITENLKRVKDIPLTLPEELDITVRGECYMPRASFDQVNQARQENGEPEFANPRNAAAGTLRQLDTAVVAKRNLATFLYQEASPSTRDSQEKGLKYLEQLGFVVNPKRILAENIDEIWNFIQEVGQERENLPYDIDGVVIKVNDLASQEELGFTVKAPKWAVAYKFPA
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
pubmed doi rcsb |
| molecule keywords |
DNA ligase
|
| molecule tags |
Ligase/ligase inhibitor
|
| source organism |
Streptococcus pneumoniae
|
| total genus |
73
|
| structure length |
275
|
| sequence length |
304
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
6.5.1.2: DNA ligase (NAD(+)). |
| pdb deposition date | 2012-08-15 |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 2-Layer Sandwich | D-amino Acid Aminotransferase; Chain A, domain 1 | D-amino Acid Aminotransferase; Chain A, domain 1 |
#chains in the Genus database with same CATH superfamily 4GLW A; 3BAC A; 1ZAU A; 3SGI A; #chains in the Genus database with same CATH topology 1CQJ B; 2HGS A; 3T9E A; 2YYA A; 2OLS A; 2NU9 B; 1OBD A; 2ZDQ A; 5DMX A; 3WWI A; 2P0A A; 3G8C A; 4E4T A; 2Z02 A; 4M0J A; 5I5X A; 1A3G A; 4C5B A; 3VPD A; 3TEK A; 3QFF A; 4MA5 A; 1ZAU A; 3WO0 A; 5CE8 A; 1EYZ A; 5FNV F; 1P16 A; 1JKJ B; 2R84 A; 3I12 A; 1T36 A; 3K5H A; 4Q4C A; 3DTF A; 3UQ8 A; 1KBL A; 5C1P A; 1IYE A; 1EUD B; 4HN2 A; 5LA6 F; 2HHF B; 4MV6 A; 1JDE A; 1DV2 A; 2XCL A; 4CKE A; 4FFP A; 5I5T A; 5BPF A; 3VA7 A; 2R86 A; 2W70 A; 5BWX A; 5KKN B; 3VMM A; 4TM5 A; 3KAL A; 4FFO A; 4O2B F; 1Z2N X; 3RV4 A; 4UCO A; 3S24 A; 4O7S A; 1TAE A; 2GLT A; 4FFR A; 5BWU A; 4HNT A; 3GLK A; 2NU8 B; 2GPS A; 2YRX A; 3BA8 A; 3TIG A; 3T9C A; 5BWV A; 5E25 A; 4MV9 A; 5GON F; 2YZG A; 2QB5 A; 3MWE A; 4MV3 A; 2I80 A; 2NU6 B; 2V59 A; 4ME6 A; 4UUG A; 3T9B A; 5BYA A; 3U54 A; 3R23 A; 5KS8 A; 2EIY A; 4NZN A; 1M0T A; 4PZ6 A; 3R5X A; 4TVI A; 2HIV A; 2IP4 A; 2DWC A; 1KT8 A; 3BG5 A; 2VUG A; 2PBZ A; 5CR5 A; 3UFX B; 3ORQ A; 4O7N A; 3T54 A; 2CNU A; 4YB8 B; 3MWD A; 2HGX A; 3CEB A; 3SGI A; 4ZOL F; 2FPG B; 3RV3 A; 3HB9 A; 4XYL B; 2W6Z A; 4IWY A; 2HDK A; 4FFM A; 4IZO A; 2ABJ A; 4O4I F; 4K6N A; 4RCN A; 1AUX A; 4I4T F; 1VS0 A; 3LP8 A; 3NUA A; 2YZL A; 5H80 A; 3TY8 A; 3V4Z A; 2FP4 B; 4PBC A; 3GJX B; 4I50 F; 4FFN A; 2CNV A; 4CC5 A; 2X5R A; 2HVQ A; 3WWH A; 4JXU A; 1OBG A; 4DQN A; 1GLV A; 5JQG F; 1DAA A; 3TW7 A; 5LYJ F; 2X0S A; 5HV6 A; 3LQS A; 2HJW A; 1XK5 A; 3QQM A; 2YWV A; 3ETH A; 5HNE A; 2ODT X; 3PFF A; 2Q2T A; 4WBN F; 2DAA A; 2COI A; 2C00 A; 4MV7 A; 3T7A A; 2EJ0 A; 3JRX A; 4YAJ B; 2HIX A; 1FVI A; 3BAB A; 5BWT A; 3W1G A; 1JDB B; 3GDE A; 1SCU B; 4M9U A; 3DF7 A; 3KAJ A; 3SNO A; 4ZHQ F; 1VBG A; 5FPR A; 2R82 A; 1IOV A; 3JZF A; 3VPB A; 2FPI B; 2W6N A; 5D1O A; 4HNU A; 1CE8 A; 4NZM A; 4O7L A; 2R85 A; 2V58 A; 2COG A; 2Z04 A; 1A0I A; 1S68 A; 5K2M A; 4EQ5 A; 1A48 A; 5BPH A; 3UYY A; 2QK4 A; 2ZDH A; 3QWU A; 3NC0 B; 4XYM B; 1EHI A; 3VNN A; 4MV1 A; 3UZB A; 2YZN A; 3LWB A; 4UCR A; 1UC8 A; 2J9G A; 4O82 A; 2Y4R A; 3WWJ A; 1I2L A; 1C3O A; 3UZO A; 2R7M A; 2GQR A; 2HG8 A; 3KYH C; 5J2U F; 2W6O A; 3AW8 A; 3BAA A; 3TY9 A; 3MJF A; 5JVD F; 4DRF A; 4O2A F; 2XD4 A; 4WHX A; 4ZI7 F; 3CSW A; 5CM0 A; 2W71 A; 3DTG A; 1KTA A; 3TW6 A; 3K3P A; 3R5H A; 2YW2 A; 5K3W A; 4CE5 A; 3OUU A; 3SE7 A; 4E6N A; 2YZM A; 2V5A A; 3JSL A; 3N8D A; 3VOT A; 2YRW A; 4O83 A; 4LH7 A; 5C8Y F; 2VQD A; 1KEE A; 4EFB A; 5I5W A; 3U9S A; 3TII A; 4NYE A; 4O84 A; 1KJJ A; 4MV8 A; 3GB8 B; 1IOW A; 3T9D A; 1A9X A; 4C5C A; 4TUY F; 2WYO A; 4O7R A; 4UCU A; 5CA1 F; 5BWR A; 1Z2P X; 1W96 A; 2W6P A; 4IIJ F; 3JZI A; 5LOV F; 5I60 A; 4XZ3 B; 1PX2 A; 4FGR A; 2PVP A; 3Q2O A; 1VKZ A; 5IYZ F; 3K5I A; 3V4S A; 5JQW A; 3JRW A; 1AUV A; 4YJ3 F; 1I7L A; 4CC6 A; 2SCU B; 1BNC A; 5I5S A; 3R5F A; 5HBR B; 2R87 A; 3R9R A; 1GSA A; 1GGO A; 5D1O B; 1M6V A; 1JLL B; 3PN1 A; 1BXR A; 2I8C A; 1GSO A; 3T99 A; 1CKO A; 2CZG A; 1KC7 A; 4CKB A; 4EGJ A; 2DZD A; 3RUP A; 3T9A A; 3LUL A; 3NBY B; 3U0G A; 1G2W A; 4NZO A; 3U9T A; 1DGS A; 2DIK A; 1M0W A; 3WO1 A; 4TV8 F; 1E4E A; 5I5Y A; 1DV1 A; 4UCT A; 2GPW A; 4UCV A; 4CMD A; 1Z2O X; 2HVS A; 2PN1 A; 1B6R A; 5LXT F; 4EFE A; 1EZ1 A; 3NBZ B; 1CQI B; 3E5N A; 5D8D A; 2VR1 A; 4FFL A; 3N6R A; 5I5U A; 1I7N A; 5D1P A; 1I1M A; 4Q4D A; 1ULZ A; 2R7N A; 1GSH A; 4EEQ A; 4CMF A; 5C1O A; 2Q7D A; 5I5V A; 4EGQ A; 1EUC B; 5CB4 F; 5JVL A; 2FB9 A; 2FPP B; 3KAK A; 4Y8V B; 2CFM A; 3JSN A; 4YBZ B; 1W93 A; 4YJ2 F; 3TIN A; 4O4H F; 5KX5 F; 4O4J F; 3W5O A; 2A1H A; 2DAB A; 4O7V A; 2HGW A; 1PK8 A; 1DIK A; 1CS0 A; 2R7K A; 1CKN A; 4IHJ F; 2YS6 A; 5DGI A; 4FE2 A; 5CAE B; 2ZGI A; 4GLW A; 3T9F A; 5DIS C; 3RR5 A; 4HQ6 A; 1B6S A; 3ORR A; 4CKC A; 2VPQ A; 4O7W A; 3U55 A; 3G8D A; 1KUT A; 4FU0 A; 4PZ7 A; 4UCS A; 1KJ8 A; 4HNV A; 4GLX A; 4LH6 A; 1KJQ A; 1V9P A; 2ZDG A; 4L1K A; 4MAM A; 3AX6 A; 3W1B A; 2R7L A; 5LP6 F; 1VBH A; 1C30 A; 2HHF A; 2HVR A; 1IYD A; 3KRE A; 3TY5 A; 4PZ8 A; 4C5A A; 2NUA B; 4DAA A; 3RFC A; 3DAA A; 4O81 A; 4ZQI A; 3BA9 A; 4RZQ A; 4DIM A; 2COJ A; 1WR2 A; 1I2K A; 2W6Q A; 3JZ6 A; 3GID A; 2EJ3 A; 5CA0 F; 4O7Z A; 4QSH A; 4DLK A; 1I1L A; 5EZY F; 1E4E B; 5JH7 F; 4CHI A; 1UC9 A; 4O7T A; 1EKP A; 4O7Y A; 1B04 A; 3HO8 A; 4O86 A; 4I55 F; 1WRV A; 4UFZ A; 2EJ2 A; 2OWO A; 3VPC A; 2YS7 A; 4MA0 A; 4MV4 A; 5J2T F; 1EKF A; 4IWX A; 1CKM A; 2W6M A; 2NU7 B; 5FR9 A; 1TA8 A; 3HBL A; 5BWW A; 1A0G A; 5DAA A; 4XX0 B; 2GQS A; 2I87 A; 2CNQ A; 4YAK B; 1I1K A; 4O4L F; 1X9N A; 1XDN A; 3WNZ A; 4EG0 A; 5BYB A; 2DLN A; 3Q1K A; 5I47 A; 3RTX A; 1EKV A; 5BMV F; 3BAC A; 1KJI A; 2QF7 A; 2Q2U A; 3ETJ A; 4HR7 A; 5FPO A; 3HT5 A; 3TQT A; 2YL2 A; 4TV9 F; 1KJ9 A; 3L2P A; 1P8L A; 3OUZ A; 5DGH A; 1ET0 A; 1CKN B; #chains in the Genus database with same CATH homology 4PBC A; 2A1H A; 2DAB A; 5I5W A; 3T9E A; 2HGW A; 5DGI A; 2ZGI A; 2X5R A; 4GLW A; 3T9F A; 3WWI A; 4M0J A; 3WWH A; 1A3G A; 5I5X A; 3VPD A; 4JXU A; 4CKC A; 3TEK A; 3T9D A; 4DQN A; 1ZAU A; 5CE8 A; 1DAA A; 3TW7 A; 5BWR A; 3LQS A; 4Q4C A; 3QQM A; 5I60 A; 3DTF A; 5HNE A; 1IYE A; 2ODT X; 3PFF A; 4HN2 A; 2HHF B; 2DAA A; 2COI A; 4CKE A; 5I5T A; 3T7A A; 2EJ0 A; 5BWX A; 2HHF A; 4TM5 A; 1IYD A; 5BWT A; 5I5S A; 4DAA A; 3DAA A; 5BWU A; 3SNO A; 2COJ A; 1I2K A; 3JZ6 A; 2EJ3 A; 3T99 A; 3T9C A; 4NZM A; 5E25 A; 5BWV A; 1I1L A; 2COG A; 4CKB A; 2QB5 A; 3T9A A; 3LUL A; 5K2M A; 4CHI A; 3U0G A; 3UYY A; 1G2W A; 4NZO A; 4UUG A; 3T9B A; 1UC9 A; 5I5Y A; 5BYA A; 1EKP A; 4CMD A; 3UZB A; 1WRV A; 2EJ2 A; 5KS8 A; 2EIY A; 4NZN A; 1EKF A; 4IWX A; 4TVI A; 1UC8 A; 5FR9 A; 2Y4R A; 3WWJ A; 1KT8 A; 1I2L A; 5BWW A; 5CR5 A; 1A0G A; 5DAA A; 3UZO A; 5I5U A; 2HG8 A; 1I1M A; 4Q4D A; 3T54 A; 4CMF A; 1I1K A; 4WHX A; 3CSW A; 5CM0 A; 2HGX A; 3CEB A; 5BYB A; 3SGI A; 3DTG A; 1KTA A; 5I47 A; 2Q7D A; 1EKV A; 5I5V A; 4IWY A; 3BAC A; 2HDK A; 3HT5 A; 5K3W A; 2ABJ A; 4CE5 A; 4K6N A; 4RCN A; 5DGH A; 1ET0 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
