The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
110
|
sequence length |
363
|
structure length |
354
|
Chain Sequence |
SSFKAADLQLEMTQKPHKKPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.
pubmed doi rcsb |
| molecule keywords |
Branched-chain-amino-acid aminotransferase, mitochondrial
|
| molecule tags |
Transferase
|
| source organism |
Homo sapiens
|
| total genus |
110
|
| structure length |
354
|
| sequence length |
363
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
2.6.1.42: Branched-chain-amino-acid transaminase. |
| pdb deposition date | 2015-06-08 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF01063 | Aminotran_4 | Amino-transferase class IV |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | Alpha-Beta Barrel | D-amino Acid Aminotransferase; Chain A, domain 2 | D-amino Acid Aminotransferase, subunit A, domain 2 | ||
| Alpha Beta | 2-Layer Sandwich | D-amino Acid Aminotransferase; Chain A, domain 1 | D-amino Acid Aminotransferase; Chain A, domain 1 |
#chains in the Genus database with same CATH superfamily 2HDK A; 5DAA A; 5I5T A; 1DAA A; 5I5U A; 3HT5 A; 2HGX A; 2HGW A; 4TM5 A; 1IYD A; 3WWI A; 4PBC A; 5E25 A; 2EJ0 A; 4DQN A; 3U0G A; 1EKF A; 1WRV A; 1I2L A; 1G2W A; 5I5S A; 1EKV A; 1I1M A; 2COI A; 5K3W A; 4CHI A; 3JZ6 A; 2EJ3 A; 5BWT A; 1KTA A; 2Y4R A; 2ABJ A; 2HHF A; 3UYY A; 5I5V A; 3DTG A; 1A3G A; 1A0G A; 5CM0 A; 3UZB A; 2DAB A; 4K6N A; 2EJ2 A; 4M0J A; 1EKP A; 5BWX A; 1IYE A; 4TVI A; 4UUG A; 1ET0 A; 3DAA A; 2COJ A; 4DAA A; 4CMF A; 3CSW A; 5I5X A; 5BWV A; 5FR9 A; 3SNO A; 5I60 A; 2A1H A; 2HHF B; 1KT8 A; 3WWJ A; 3CEB A; 2COG A; 4CMD A; 4CE5 A; 5BWW A; 1I2K A; 3QQM A; 3WWH A; 5HNE A; 5I5W A; 1I1L A; 4WHX A; 2EIY A; 2DAA A; 2ZGI A; 5CR5 A; 3LQS A; 5I5Y A; 3DTF A; 5BWU A; 3UZO A; 3LUL A; 4JXU A; 1I1K A; 5CE8 A; 2HG8 A; 5BWR A; #chains in the Genus database with same CATH topology 2FPP B; 1E4E B; 3RR5 A; 1DV2 A; 4EG0 A; 3RFC A; 1S68 A; 3G8D A; 1A9X A; 2ZDH A; 2IP4 A; 3GB8 B; 4MV1 A; 4RZQ A; 3GID A; 2HVQ A; 1EUC B; 4ME6 A; 1DIK A; 1M6V A; 3Q2O A; 2HGX A; 5D1P A; 1GLV A; 5J2T F; 3TY9 A; 4C5C A; 3SGI A; 3WWI A; 5E25 A; 4DQN A; 4PZ8 A; 2OWO A; 2GPS A; 1WRV A; 1I7N A; 4YB8 B; 3NUA A; 1DGS A; 2R84 A; 4NYE A; 1GSO A; 5FPO A; 1I1M A; 5K3W A; 4LH6 A; 4QSH A; 4CHI A; 4UFZ A; 4GLX A; 3JZ6 A; 4MV6 A; 5KS8 A; 4E4T A; 1KTA A; 3WO0 A; 3W1B A; 2HHF A; 3E5N A; 5CM0 A; 1A3G A; 3Q1K A; 4EGQ A; 5HV6 A; 2PN1 A; 4M9U A; 1CQJ B; 3HBL A; 4M0J A; 4ZI7 F; 4IHJ F; 2CFM A; 1JLL B; 4UCO A; 4TVI A; 4UUG A; 4UCT A; 2YS7 A; 1A48 A; 3BG5 A; 3RUP A; 1KJQ A; 2W71 A; 3DAA A; 2COJ A; 1M0W A; 1B6S A; 4CMF A; 3TW6 A; 4CKB A; 5BYA A; 4FFL A; 4I50 F; 5JVD F; 3T9C A; 4PZ7 A; 1KJ9 A; 4HNT A; 2ODT X; 2J9G A; 3K3P A; 3U54 A; 2HHF B; 3T9E A; 1CKO A; 1KT8 A; 3HB9 A; 2X5R A; 5JQW A; 3VMM A; 1JDE A; 4HR7 A; 4L1K A; 2Z04 A; 4FE2 A; 4FFR A; 3KAL A; 5BWW A; 4XZ3 B; 1PX2 A; 1C30 A; 2VQD A; 4WBN F; 4FGR A; 5K2M A; 4Y8V B; 2R82 A; 4O7N A; 3MJF A; 4O7Z A; 2P0A A; 3OUZ A; 2R86 A; 4MA5 A; 4WHX A; 1Z2N X; 3ORQ A; 1GSA A; 4CC5 A; 4TUY F; 4YBZ B; 2YW2 A; 4O7Y A; 2ZGI A; 3NC0 B; 4IIJ F; 5CR5 A; 2YZG A; 4MV7 A; 4PZ6 A; 4RCN A; 3VNN A; 3LUL A; 2HJW A; 2FPI B; 4YAK B; 2YRX A; 3MWD A; 4IWY A; 4C5A A; 4O7T A; 1IOW A; 5JQG F; 1E4E A; 2FPG B; 1T36 A; 3JSL A; 1JKJ B; 2PVP A; 1X9N A; 2R7K A; 1EUD B; 1VBG A; 2DLN A; 4TV9 F; 1P16 A; 1IYD A; 3R5H A; 4FFM A; 3KAK A; 3LP8 A; 2FP4 B; 4NZN A; 2EJ0 A; 4HNV A; 4O84 A; 1IOV A; 2GQS A; 3RTX A; 2W6N A; 1G2W A; 4ZOL F; 3WO1 A; 1W96 A; 5I5S A; 3VPB A; 1Z2P X; 1SCU B; 2ZDG A; 1UC8 A; 4HQ6 A; 3V4Z A; 2YWV A; 4UCR A; 2Y4R A; 3TY5 A; 2YL2 A; 2GPW A; 5BPH A; 5I5V A; 1DV1 A; 4O82 A; 5BMV F; 4ZHQ F; 5DGH A; 3BAB A; 4K6N A; 4IZO A; 4O86 A; 1KJJ A; 2EJ2 A; 4UCS A; 2NU9 B; 2HVR A; 1BNC A; 1ET0 A; 1FVI A; 2R7L A; 2OLS A; 3VA7 A; 4EGJ A; 2DZD A; 3N6R A; 5I5X A; 3LWB A; 4O7S A; 4EFB A; 3G8C A; 2A1H A; 1CE8 A; 2XD4 A; 2Q2T A; 4HNU A; 2W6O A; 3I12 A; 3QWU A; 1Z2O X; 3ETH A; 3N8D A; 3RV3 A; 3AX6 A; 3JZI A; 4MA0 A; 4MV8 A; 3SE7 A; 3T7A A; 1I2K A; 2W6Q A; 3QQM A; 3BAC A; 5HNE A; 1CQI B; 2DIK A; 3R23 A; 3WNZ A; 3OUU A; 2XCL A; 4UCV A; 2NUA B; 2DAA A; 3JRW A; 3U55 A; 3LQS A; 1PK8 A; 5I5Y A; 2R85 A; 4XYL B; 3NBY B; 4NZO A; 1ULZ A; 4DIM A; 4FFN A; 2C00 A; 5D8D A; 3NBZ B; 2Q2U A; 3ETJ A; 1AUV A; 5C8Y F; 1I7L A; 2HDK A; 5DAA A; 1CKM A; 5C1P A; 4CC6 A; 5JH7 F; 1TAE A; 3TEK A; 4O2B F; 1TA8 A; 5LYJ F; 3HT5 A; 1XDN A; 2QF7 A; 3BAA A; 4TM5 A; 5FNV F; 2QK4 A; 3T9F A; 2I8C A; 3TIG A; 3HO8 A; 3R9R A; 5JVL A; 1A0I A; 3TII A; 3U0G A; 5DMX A; 1EKF A; 1VS0 A; 3JSN A; 4C5B A; 4E6N A; 3VOT A; 2I87 A; 2EJ3 A; 1CKN A; 5HBR B; 1KC7 A; 2ABJ A; 5KKN B; 3UYY A; 4O7R A; 2CZG A; 1GSH A; 2W6Z A; 2R7M A; 2YRW A; 3U9S A; 3ORR A; 1EKP A; 1GGO A; 2V59 A; 1EZ1 A; 1IYE A; 5J2U F; 2VUG A; 4FU0 A; 2VR1 A; 4Q4D A; 1VKZ A; 4O4J F; 2CNQ A; 4FFP A; 4DAA A; 3RV4 A; 3R5F A; 5IYZ F; 5FR9 A; 3T99 A; 1UC9 A; 3T9A A; 1CKN B; 3PFF A; 5I60 A; 2W6P A; 4DLK A; 2I80 A; 4O7L A; 1M0T A; 3PN1 A; 3WWJ A; 2V58 A; 2YZM A; 5FPR A; 4O2A F; 2HVS A; 5DGI A; 3JZF A; 2HGS A; 4O4H F; 4NZM A; 4CMD A; 4I55 F; 4O4I F; 3WWH A; 4EEQ A; 5I5W A; 2YYA A; 1B6R A; 3QFF A; 4O7W A; 2EIY A; 3U9T A; 3GLK A; 1EHI A; 3W5O A; 1KUT A; 5KX5 F; 4O4L F; 3VPD A; 4XX0 B; 3BA9 A; 4Q4C A; 1BXR A; 1W93 A; 3DTF A; 2YZN A; 4GLW A; 5I47 A; 5BWU A; 3UZO A; 1I1K A; 2GLT A; 3TY8 A; 4FFO A; 2W70 A; 1KJ8 A; 3GDE A; 3VPC A; 2Q7D A; 4LH7 A; 5BYB A; 3GJX B; 5I5T A; 2R87 A; 4XYM B; 3TIN A; 2NU7 B; 3TQT A; 5CA1 F; 1DAA A; 5I5U A; 5D1O A; 2HGW A; 4CKC A; 3R5X A; 2HIX A; 1VBH A; 4PBC A; 2ZDQ A; 4O81 A; 2NU8 B; 3K5H A; 3UFX B; 5LP6 F; 5CA0 F; 3KAJ A; 1I2L A; 2PBZ A; 3MWE A; 1EKV A; 4MV3 A; 2COI A; 4HN2 A; 4YJ2 F; 3TW7 A; 4CKE A; 1XK5 A; 5H80 A; 5CB4 F; 5BWT A; 1P8L A; 5EZY F; 1OBG A; 4MV4 A; 2V5A A; 3BA8 A; 4YAJ B; 3DTG A; 1A0G A; 1AUX A; 5D1O B; 3UZB A; 1CS0 A; 2DAB A; 4I4T F; 4DRF A; 2W6M A; 5C1O A; 1KJI A; 4EQ5 A; 5BWX A; 2VPQ A; 5LOV F; 5LXT F; 4O7V A; 2WYO A; 5BPF A; 1JDB B; 2DWC A; 1WR2 A; 3CSW A; 5BWV A; 2YS6 A; 1KEE A; 3SNO A; 2NU6 B; 4UCU A; 3L2P A; 2QB5 A; 5LA6 F; 3DF7 A; 3AW8 A; 2Z02 A; 2X0S A; 2GQR A; 3T9D A; 4ZQI A; 4EFE A; 2CNU A; 4YJ3 F; 3V4S A; 3W1G A; 3CEB A; 4TV8 F; 2COG A; 1OBD A; 4CE5 A; 1B04 A; 2FB9 A; 3KRE A; 2SCU B; 3T54 A; 3UQ8 A; 2R7N A; 1KBL A; 1I1L A; 2HIV A; 1ZAU A; 1C3O A; 4O83 A; 1EYZ A; 1V9P A; 3JRX A; 5DIS C; 4MV9 A; 5GON F; 3S24 A; 4IWX A; 5CAE B; 4MAM A; 3KYH C; 4JXU A; 5CE8 A; 2HG8 A; 3T9B A; 3K5I A; 2YZL A; 5BWR A; 2CNV A; #chains in the Genus database with same CATH homology 2HDK A; 5DAA A; 5BYB A; 5I5T A; 3TEK A; 1DAA A; 5I5U A; 3HT5 A; 2HGX A; 2HGW A; 4CKC A; 4TM5 A; 1IYD A; 3T9F A; 3SGI A; 3WWI A; 4PBC A; 5E25 A; 4NZN A; 2EJ0 A; 4DQN A; 3U0G A; 1EKF A; 1WRV A; 1I2L A; 1G2W A; 5I5S A; 1EKV A; 1I1M A; 2COI A; 5K3W A; 4HN2 A; 3TW7 A; 4CHI A; 4CKE A; 3JZ6 A; 2EJ3 A; 5BWT A; 5KS8 A; 1UC8 A; 1KTA A; 2Y4R A; 2ABJ A; 2HHF A; 3UYY A; 5I5V A; 3DTG A; 1A3G A; 1A0G A; 5CM0 A; 3UZB A; 5DGH A; 2DAB A; 4K6N A; 2EJ2 A; 4M0J A; 1EKP A; 5BWX A; 1IYE A; 4TVI A; 4UUG A; 4Q4D A; 1ET0 A; 3DAA A; 2COJ A; 4DAA A; 4CMF A; 3CSW A; 4CKB A; 5I5X A; 5BWV A; 5FR9 A; 5BYA A; 3T99 A; 3SNO A; 1UC9 A; 3T9A A; 3T9C A; 3PFF A; 5I60 A; 2A1H A; 2QB5 A; 2ODT X; 2HHF B; 3T9E A; 3T9D A; 1KT8 A; 3WWJ A; 2X5R A; 5DGI A; 3CEB A; 2COG A; 4NZM A; 4CMD A; 4CE5 A; 5BWW A; 3T7A A; 1I2K A; 3QQM A; 3WWH A; 3BAC A; 5HNE A; 3T54 A; 5I5W A; 5K2M A; 1I1L A; 1ZAU A; 4WHX A; 2EIY A; 2DAA A; 2ZGI A; 5CR5 A; 3VPD A; 3LQS A; 4IWX A; 5I5Y A; 4Q4C A; 4NZO A; 5I47 A; 3DTF A; 4GLW A; 4RCN A; 5BWU A; 3UZO A; 3LUL A; 4JXU A; 1I1K A; 5CE8 A; 2HG8 A; 3T9B A; 4IWY A; 5BWR A; 2Q7D A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
