3ZM5A

Crystal structure of murf ligase in complex with cyanothiophene inhibitor
Total Genus 143
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
143
sequence length
454
structure length
454
Chain Sequence
MKLTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVPLKGARDGHDFIETAFENGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTVDVFAVTGSNGKTTTKDMLAHLLSTRYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMGQDHLGDIHLLSELARPKTAIVTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLLLAPADPIVEDYLPIDKKVVRFGQGAELEITDLVERKDSLTFKANFLEQALDLPVTGKYNATNAMIASYVALQEGVSEEQIRLAFQHLELTRNRTEWKKAANGADILSDVYNANPTAMKLILETFSAIPANEGGKKIAVLADMKELGDQSVQLHNQMILSLSPDVLDIVIFYGEDIAQLAQLASQMFPIGHVYYFKKTEDQDQFEDLVKQVKESLGAHDQILLKGSNSMNLAKLVESLEN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Activity Relationships of New Cyanothiophene Inhibitors of the Essential Peptidoglycan Biosynthesis Enzyme Murf.
pubmed doi rcsb
molecule tags Ligase
source organism Streptococcus pneumoniae r6
molecule keywords UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE
total genus 143
structure length 454
sequence length 454
ec nomenclature ec 6.3.2.10: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase.
pdb deposition date 2013-02-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01225 Mur_ligase Mur ligase family, catalytic domain
A PF02875 Mur_ligase_C Mur ligase family, glutamate ligase domain
A PF08245 Mur_ligase_M Mur ligase middle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1190.10 Alpha Beta 3-Layer(aba) Sandwich UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase Mur-like, catalytic domain 3zm5A02
3.40.1390.10 Alpha Beta 3-Layer(aba) Sandwich Udp-n-acetylmuramoylalanyl-d-glutamate--2,6- Diaminopimelate Ligase; Chain: A, domain 1 MurE/MurF, N-terminal domain 3zm5A01
3.90.190.20 Alpha Beta Alpha-Beta Complex Protein-Tyrosine Phosphatase; Chain A Mur ligase, C-terminal domain 3zm5A03
1W7KA 3EH0A 1O5ZA 4BUCA 2XJAA 2IUAA 4ZIYA 2JFHA 4CVLA 1P3DA 4BUBA 1W78A 3N2AA 3LK7A 1J6UA 3NRSA 1GQYA 1GG4A 3PMOA 1JBWA 4E75A 4IHHA 3ZM5A 2VTDA 2VOSA 4C12A 2GC5A 1JBVA 1EEHA 5A5FA 2WJPA 2Y1OA 3HN7A 3ZM6A 3MVNA 2IU9A 4QF5A 1E0DA 1UAGA 2GCAA 4HV4A 5A5EA 4E79A 2GCBA 2VTEA 2JFFA 2VORA 2UUOA 4CVMA 2F00A 2GC6A 1GQQA 2AM2A 2XPCA 4IHFA 2AM1A 3EAGA 1E8CA 3QCZA 2WTZA 1P31A 4UAGA 2Y66A 3PYZA 3UAGA 2Y68A 1FGSA 4QDIA 4C13A 2X5OA 2UUPA 2JFGA 3ZL8A 4CVKA 2UAGA 4IHGA 2Y67A 2IU8A
chains in the Genus database with same CATH superfamily
1C84A 4D3PA 1W7KA 3B1NA 4RDDA 3WSDA 3A5KA 3MMJA 3QCMA 3ZMPA 4XDAA 1VK4A 2CNGA 1UA4A 3RPHA 3EWMA 3QCIA 2F6WA 3B1PA 2ESBA 1V19A 2NWHA 1VI9A 2JFHA 1DGMA 2AHSA 1JF7A 4RI5A 3RTAA 4RKKA 1V1SA 5KA0A 3NL2A 3BM8A 1P3DA 1G4US 4BUBA 4KBEA 5K24A 3LHXA 1D5RA 4JMJA 1J6UA 2NT7A 2OUDA 1UB0A 2IOJA 3NRSA 4E84A 5KACA 1GQYA 5I6VA 2VEUA 2F6FA 3WSFA 4WU2A 4KYRA 5K9VA 3ZM3A 1C88A 5TRWA 1C86A 2CM8A 2CMBA 3IKHA 2OOQA 2HY3A 4E75A 2B07A 2I6IA 2QBRA 1OEMX 4XF6A 2PKKA 2H4VA 5KA7A 2HNPA 3V0FA 4E8ZA 5C3YA 1PA1A 2ZN7A 3SR9A 2I6AA 1G1GA 4IKCA 1U26A 2QCTA 2H4KA 4NNDA 3NC2A 2J16A 1OEVA 2FH7A 4BPCA 4K8PA 3H74A 3RPZA 2VEYA 3ZM0A 1Q6TA 4O1GA 1EEHA 4JKSA 2Y1OA 1RFUA 1J4XA 3IBQA 2IU9A 1JXIA 5CGEA 3A5JA 4S0GA 3GBUA 4O1LA 2FJMA 1VHRA 4GS0A 1OHDA 4K8KA 1KAKA 4GE2A 3RRBA 1I9TA 3I36A 1RKSA 3I7ZA 4PYHA 5J8RA 1AAXA 1YTWA 3ZMQA 4LC4A 2PI7A 4N08A 2GCBA 4U7XA 2YDUA 4E3AA 5KA3A 4DGXA 3RREA 4YAAA 3ZM2A 4E8YA 4GWFA 2F7KA 3KEUA 2QCVA 1QZ0A 1RPMA 2OC3A 2GC6A 2R0BA 4RHGA 1YPTA 3LOOA 2HC2A 3K9EA 3V0EA 1ECVA 3RQ2A 3S3EA 3HICA 4C5NA 1LHPA 1RXDA 1E8CA 5BZZA 2PQ5A 3NL6A 1LIKA 2GWOA 1VM7A 2H03A 1LQFA 2NZ6A 4MBBA 1FGSA 1R6HA 2F46A 4C13A 2DDOA 4RH5A 2HXPA 3EAXA 4WOHA 1FQ1A 4EOHA 1I57A 2B4PA 3V0DA 2AB8A 1WCHA 4R0TA 3PS5A 3D44A 2JFGA 2F6VA 5KA2A 1LHRA 3RS9A 2A9YA 3HJ6A 4CVKA 3OTXA 2Y2FA 3RO1A 3GXGA 2GJTA 3QA2A 3S3FA 2P6XA 1YGJA 1OHCA 2ZMMA 1C87A 2V78A 3EH0A 3RT7A 2F70A 4KANA 4BJOA 5K9WA 4BUCA 2I4GA 4Z6BA 2IUAA 4ZIYA 1LYVA 3F9AA 4S1HA 1RKAA 4QAPA 3MOZA 5MMZB 3CWEA 3RO4A 1ESQA 3BF5A 2PA5A 1C3QA 4EUMA 3BLTA 3RQXA 3EZZA 4GRYA 4QBEA 3D1QA 3O4TA 3N2AA 1U2XA 3LK7A 1GC5A 3RS8A 1NZ7A 2FV7A 3D1OA 3RM5A 1XBOA 4HJQA 3HPDA 4X8FA 1OHEA 4KALA 4PVVA 1Q6JA 3PMOA 1V1AA 2BV5A 2PSZA 3ZM1A 4GM6A 2M3VA 1M3GA 3BRHA 4D3QA 3NCAA 5LXQB 3RRFA 2AJPA 4KAHA 1C83A 2RF6A 4E69A 2Y67A 3RY7A 5KABA 3S3HA 5EYNA 4QUMA 4E8WA 1ZC0A 1JLNA 1GFYA 1OETA 4UBEA 4YWRA 1G4WR 2CNHA 4K93A 5AWXA 2WJPA 1Q6SA 1V3AA 3HN7A 3IH0A 2WGPA 5IBMA 3F9BA 2CNFA 1TZ6A 1TZ3A 3QCCA 4H1OA 1OESA 3AWEA 2RBCA 2B4SA 2I3UA 3B3LA 3RSGA 1PTUA 1T49A 3O5XA 1XM2A 1PH0A 2YXTA 3RQ6A 4E79A 1YFOA 2HLZA 3B1QA 3PL2A 5BYDA 4C5LA 3RT9A 1KYHA 2F6TA 4NWFA 3EU0A 2F00A 5BYEA 1G7FA 4K8TA 4C5MA 5GTJA 3HYOA 1GQQA 1T48A 3DRWA 3QCJA 1BX4A 5K23A 3W4SA 2DDWA 4HJPA 5B6AA 2AM1A 5K25A 3NBWA 3EAGA 4K9CA 4DC3A 1P31A 5COJA 5C40A 3EEQA 2PT0A 3OMHA 2Y66A 3V0IA 4NX8A 3PYZA 4YL5A 3F41A 2Y68A 2E0TA 1V1BA 2QEPA 1BZHA 1SUGA 1LARA 2PBNA 2UUPA 4B04A 5KAAA 3UQ9A 1NWLA 2B3OA 2QBPA 1YGRA 1BZCA 5BUGA 5KADA 2FJNA 3ZL8A 2UAGA 2DXPA 2A3KA 4LCAA 3QCBA 2QBSA 2CFVA 4IHGA 4XF7A 3WSIA 4K9IA 3VASA 2CM2A 4B8RA 3H2XA 3AWFA 3SMEA 3UQEA 2HQQA 2IU8A 2A9ZA 2AJRA 4OHIA 1I9SA 4S1MA 4GFVA 3NMEA 2B49A 1T4JA 3LJSA 1XXVA 1RK2A 1RFTA 4AZ1A 2JJDA 3I80A 2XJAA 3D1HA 4Y2EA 4WU3A 2G6ZA 2I6MA 4ERCA 2CJZA 2I5XA 1Q6MA 2BGDA 4NWGA 1JXHA 3FHYA 2NT2A 1YHJA 2VARA 1W78A 3ZS7A 4EBUA 1FPZA 5M43A 2AA0A 4ZRTA 3MOWA 3RRJA 1BZJA 3N0AA 4R0SA 1KO7A 1G1FA 1Q6NA 2IMGA 2R3BA 2QCJA 3QCEA 1JBWA 4DU5A 3B1OA 2AX3A 4EN4A 3CM3A 4H34A 3EMUA 2AFBA 2J17A 1XXPA 3DZVA 4GE6A 2I6PA 4GE5A 1ONYA 3IQ0A 2MBCA 2SHPA 1P15A 4OHLA 3ZM5A 4S1IB 3RTEA 3QKQA 1U25A 4JNBA 3UBOA 1WRMA 4ICZA 1L2LA 2GC5A 1JBVA 5A5FA 3L31A 3U96A 3RTCA 2HNQA 3O3LA 2JG1A 3ZM6A 3MVNA 1XRIA 3V0HA 4QF5A 2PKMA 1E0DA 4QUNA 1UAGA 2GCAA 1WYEA 2Q47A 2HC1A 2CM7A 2JGVA 3VAQA 2QDCA 3MBHA 5K22A 3MBJA 3S4OA 3QCFA 2I42A 3QCGA 4RH9A 4JJPA 2PKNA 1YN9A 1EKKA 2VTEA 4HRFA 4JKUA 2JFFA 1ONZA 1LIOA 3CQDA 3RQ5A 2I6OA 1PYNA 3EB1A 4CVMA 3KZHA 1X24A 5BX1A 2AM2A 3QKPA 3JULA 2CNIA 2XPCA 2P4DA 1ESJA 4IHFA 4PVGA 4S1IA 1NMOA 3RTBA 3O4SA 3F81A 3QCZA 3AWGA 5CGAA 4UAGA 5IBSA 1KNXA 2AZRA 5BZXA 2CM3A 4JMKA 3RQHA 3RQ8A 5BYCA 3L2BA 3M4UA 3LKIA 2X5OA 4RI4A 3K5WA 2I6BA 5F0ZA 4N09A 1LIJA 3V0GA 4Y14A 4LBXA 2QHPA 1NL9A 5C3ZA 4DGPA 3QCLA 2PKFA 1U24A 1OEOX 1YGKA 3KTNA 4R30A 3Q92A 1NO6A 5KA9A 1L8KA 2NLKA 1L8GA 4XCKA 3NM1A 2DCNA 4C5KA 1TYYA 2YYBA 2I1YA 1O5ZA 2BIJA 3QCHA 1G7GA 3RU3A 1PA9A 2AWDA 1MKPA 4NYHA 1GWZA 3LJ8A 5BYFA 3F99A 4CVLA 1ZZWA 4IWMA 3UQ6A 1QXKA 1NMPA 2I4HA 3RSQA 4QAHA 2C46A 1ZCKA 2GP0A 2I3RA 2VEWA 3RQQA 2QBQA 5EHPA 1GG4A 3IN1A 2BZLA 4ZN5A 2ABSA 2CNEA 3RGQA 3RU2A 4GFUA 4C5JA 4OHHA 3QAIA 2HVLA 5HDEA 2I75A 4B8SA 1KAVA 3NL5A 1ZCLA 4IHHA 2I4EA 3OLRA 1NNYA 2VEVA 1YTSA 3B1RA 2QDPA 3RGOA 4LBGA 1OEUA 2VTDA 2I6JA 2VOSA 4C12A 3KD6A 4KADA 5C41A 4IWGA 1Q1MA 4OHEA 2C49A 1RKDA 5KA8A 1FPRA 4I8NA 2NTAA 5CM5A 3Q1YA 3D42A 2I5BA 1LIIA 3NBVA 4WJMA 1C85A 3RTDA 4HV4A 2F71A 3FHXA 2F02A 2Y96A 5A5EA 1PXHA 4KYQA 1A5YA 4JBCA 4OHDA 4QBWA 3IE7A 3RTGA 5KA4A 3S3KA 2CMCA 1PTYA 3RZ2A 1EEOA 1GQTA 2C4EA 3GO7A 3GO6A 2CMAA 2G59A 2JG5A 2NV5A 2VEXA 1WAXA 2VORA 1YGUA 4J51A 1PTTA 3RSFA 3PZSA 2UUOA 2YXUA 5KA1A 3QCKA 1EKQA 4YR8B 1NWEA 1YTNA 3QCNA 3NC9A 3UMOA 1EENA 1PTVA 2R3EA 2QDMA 2DDMA 2XTBA 5EY7A 3B7OA 5EHRA 2ABQA 2FYWA 2F6YA 2H04A 3NL3A 3I3YA 3BLUA 3WSGA 2WTZA 2BGEA 3RSSA 3O4UA 3BGKA 2HW1A 3WSHA 3GXHA 5F11A 4GRZA 3UAGA 1RFVA 4ZI4A 2HB1A 3NM3A 4K8CA 4QDIA 3QCDA 2F6ZA 2Q05A 2A8BA 3S4EA 4D3RA 1G1HA 1YZ4A 4KI9A 4TVVA 2H02A 3ZV2A 4WTYA 2B4OA 2H4GA 2B4UA 1TD2A 2C7SA 1Q6PA 2OZ5A 3WSEA 5TQIA 2HCMA 2Q5RA 2J16B 3H49A 3D9CA 3UMPA 3N1CA 3V0JA 1YWFA 3UQDA
chains in the Genus database with same CATH topology
1W7KA 3EH0A 1O5ZA 4BUCA 2XJAA 2IUAA 4ZIYA 2JFHA 4CVLA 1P3DA 4BUBA 1W78A 3N2AA 3LK7A 1J6UA 3NRSA 1GQYA 1GG4A 3PMOA 1JBWA 4E75A 4IHHA 3ZM5A 2VTDA 2VOSA 4C12A 2GC5A 1JBVA 1EEHA 5A5FA 2WJPA 2Y1OA 3HN7A 3ZM6A 3MVNA 2IU9A 4QF5A 1E0DA 1UAGA 2GCAA 4HV4A 5A5EA 4E79A 2GCBA 2VTEA 2JFFA 2VORA 2UUOA 4CVMA 2F00A 2GC6A 1GQQA 2AM2A 2XPCA 4IHFA 2AM1A 3EAGA 1E8CA 3QCZA 2WTZA 1P31A 4UAGA 2Y66A 3PYZA 3UAGA 2Y68A 1FGSA 4QDIA 4C13A 2X5OA 2UUPA 2JFGA 3ZL8A 4CVKA 2UAGA 4IHGA 2Y67A 2IU8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1W7K A;  3EH0 A;  1O5Z A;  4BUC A;  2XJA A;  2IUA A;  4ZIY A;  2JFH A;  4CVL A;  1P3D A;  4BUB A;  1W78 A;  3N2A A;  3LK7 A;  1J6U A;  3NRS A;  1GQY A;  1GG4 A;  3PMO A;  1JBW A;  4E75 A;  4IHH A;  3ZM5 A;  2VTD A;  2VOS A;  4C12 A;  2GC5 A;  1JBV A;  1EEH A;  5A5F A;  2WJP A;  2Y1O A;  3HN7 A;  3ZM6 A;  3MVN A;  2IU9 A;  4QF5 A;  1E0D A;  1UAG A;  2GCA A;  4HV4 A;  5A5E A;  4E79 A;  2GCB A;  2VTE A;  2JFF A;  2VOR A;  2UUO A;  4CVM A;  2F00 A;  2GC6 A;  1GQQ A;  2AM2 A;  2XPC A;  4IHF A;  2AM1 A;  3EAG A;  1E8C A;  3QCZ A;  2WTZ A;  1P31 A;  4UAG A;  2Y66 A;  3PYZ A;  3UAG A;  2Y68 A;  1FGS A;  4QDI A;  4C13 A;  2X5O A;  2UUP A;  2JFG A;  3ZL8 A;  4CVK A;  2UAG A;  4IHG A;  2Y67 A;  2IU8 A; 
#chains in the Genus database with same CATH topology
 1C84 A;  4D3P A;  1W7K A;  3B1N A;  4RDD A;  3WSD A;  3A5K A;  3MMJ A;  3QCM A;  3ZMP A;  4XDA A;  1VK4 A;  2CNG A;  1UA4 A;  3RPH A;  3EWM A;  3QCI A;  2F6W A;  3B1P A;  2ESB A;  1V19 A;  2NWH A;  1VI9 A;  2JFH A;  1DGM A;  2AHS A;  1JF7 A;  4RI5 A;  3RTA A;  4RKK A;  1V1S A;  5KA0 A;  3NL2 A;  3BM8 A;  1P3D A;  1G4U S;  4BUB A;  4KBE A;  5K24 A;  3LHX A;  1D5R A;  4JMJ A;  1J6U A;  2NT7 A;  2OUD A;  1UB0 A;  2IOJ A;  3NRS A;  4E84 A;  5KAC A;  1GQY A;  5I6V A;  2VEU A;  2F6F A;  3WSF A;  4WU2 A;  4KYR A;  5K9V A;  3ZM3 A;  1C88 A;  5TRW A;  1C86 A;  2CM8 A;  2CMB A;  3IKH A;  2OOQ A;  2HY3 A;  4E75 A;  2B07 A;  2I6I A;  2QBR A;  1OEM X;  4XF6 A;  2PKK A;  2H4V A;  5KA7 A;  2HNP A;  3V0F A;  4E8Z A;  5C3Y A;  1PA1 A;  2ZN7 A;  3SR9 A;  2I6A A;  1G1G A;  4IKC A;  1U26 A;  2QCT A;  2H4K A;  4NND A;  3NC2 A;  2J16 A;  1OEV A;  2FH7 A;  4BPC A;  4K8P A;  3H74 A;  3RPZ A;  2VEY A;  3ZM0 A;  1Q6T A;  4O1G A;  1EEH A;  4JKS A;  2Y1O A;  1RFU A;  1J4X A;  3IBQ A;  2IU9 A;  1JXI A;  5CGE A;  3A5J A;  4S0G A;  3GBU A;  4O1L A;  2FJM A;  1VHR A;  4GS0 A;  1OHD A;  4K8K A;  1KAK A;  4GE2 A;  3RRB A;  1I9T A;  3I36 A;  1RKS A;  3I7Z A;  4PYH A;  5J8R A;  1AAX A;  1YTW A;  3ZMQ A;  4LC4 A;  2PI7 A;  4N08 A;  2GCB A;  4U7X A;  2YDU A;  4E3A A;  5KA3 A;  4DGX A;  3RRE A;  4YAA A;  3ZM2 A;  4E8Y A;  4GWF A;  2F7K A;  3KEU A;  2QCV A;  1QZ0 A;  1RPM A;  2OC3 A;  2GC6 A;  2R0B A;  4RHG A;  1YPT A;  3LOO A;  2HC2 A;  3K9E A;  3V0E A;  1ECV A;  3RQ2 A;  3S3E A;  3HIC A;  4C5N A;  1LHP A;  1RXD A;  1E8C A;  5BZZ A;  2PQ5 A;  3NL6 A;  1LIK A;  2GWO A;  1VM7 A;  2H03 A;  1LQF A;  2NZ6 A;  4MBB A;  1FGS A;  1R6H A;  2F46 A;  4C13 A;  2DDO A;  4RH5 A;  2HXP A;  3EAX A;  4WOH A;  1FQ1 A;  4EOH A;  1I57 A;  2B4P A;  3V0D A;  2AB8 A;  1WCH A;  4R0T A;  3PS5 A;  3D44 A;  2JFG A;  2F6V A;  5KA2 A;  1LHR A;  3RS9 A;  2A9Y A;  3HJ6 A;  4CVK A;  3OTX A;  2Y2F A;  3RO1 A;  3GXG A;  2GJT A;  3QA2 A;  3S3F A;  2P6X A;  1YGJ A;  1OHC A;  2ZMM A;  1C87 A;  2V78 A;  3EH0 A;  3RT7 A;  2F70 A;  4KAN A;  4BJO A;  5K9W A;  4BUC A;  2I4G A;  4Z6B A;  2IUA A;  4ZIY A;  1LYV A;  3F9A A;  4S1H A;  1RKA A;  4QAP A;  3MOZ A;  5MMZ B;  3CWE A;  3RO4 A;  1ESQ A;  3BF5 A;  2PA5 A;  1C3Q A;  4EUM A;  3BLT A;  3RQX A;  3EZZ A;  4GRY A;  4QBE A;  3D1Q A;  3O4T A;  3N2A A;  1U2X A;  3LK7 A;  1GC5 A;  3RS8 A;  1NZ7 A;  2FV7 A;  3D1O A;  3RM5 A;  1XBO A;  4HJQ A;  3HPD A;  4X8F A;  1OHE A;  4KAL A;  4PVV A;  1Q6J A;  3PMO A;  1V1A A;  2BV5 A;  2PSZ A;  3ZM1 A;  4GM6 A;  2M3V A;  1M3G A;  3BRH A;  4D3Q A;  3NCA A;  5LXQ B;  3RRF A;  2AJP A;  4KAH A;  1C83 A;  2RF6 A;  4E69 A;  2Y67 A;  3RY7 A;  5KAB A;  3S3H A;  5EYN A;  4QUM A;  4E8W A;  1ZC0 A;  1JLN A;  1GFY A;  1OET A;  4UBE A;  4YWR A;  1G4W R;  2CNH A;  4K93 A;  5AWX A;  2WJP A;  1Q6S A;  1V3A A;  3HN7 A;  3IH0 A;  2WGP A;  5IBM A;  3F9B A;  2CNF A;  1TZ6 A;  1TZ3 A;  3QCC A;  4H1O A;  1OES A;  3AWE A;  2RBC A;  2B4S A;  2I3U A;  3B3L A;  3RSG A;  1PTU A;  1T49 A;  3O5X A;  1XM2 A;  1PH0 A;  2YXT A;  3RQ6 A;  4E79 A;  1YFO A;  2HLZ A;  3B1Q A;  3PL2 A;  5BYD A;  4C5L A;  3RT9 A;  1KYH A;  2F6T A;  4NWF A;  3EU0 A;  2F00 A;  5BYE A;  1G7F A;  4K8T A;  4C5M A;  5GTJ A;  3HYO A;  1GQQ A;  1T48 A;  3DRW A;  3QCJ A;  1BX4 A;  5K23 A;  3W4S A;  2DDW A;  4HJP A;  5B6A A;  2AM1 A;  5K25 A;  3NBW A;  3EAG A;  4K9C A;  4DC3 A;  1P31 A;  5COJ A;  5C40 A;  3EEQ A;  2PT0 A;  3OMH A;  2Y66 A;  3V0I A;  4NX8 A;  3PYZ A;  4YL5 A;  3F41 A;  2Y68 A;  2E0T A;  1V1B A;  2QEP A;  1BZH A;  1SUG A;  1LAR A;  2PBN A;  2UUP A;  4B04 A;  5KAA A;  3UQ9 A;  1NWL A;  2B3O A;  2QBP A;  1YGR A;  1BZC A;  5BUG A;  5KAD A;  2FJN A;  3ZL8 A;  2UAG A;  2DXP A;  2A3K A;  4LCA A;  3QCB A;  2QBS A;  2CFV A;  4IHG A;  4XF7 A;  3WSI A;  4K9I A;  3VAS A;  2CM2 A;  4B8R A;  3H2X A;  3AWF A;  3SME A;  3UQE A;  2HQQ A;  2IU8 A;  2A9Z A;  2AJR A;  4OHI A;  1I9S A;  4S1M A;  4GFV A;  3NME A;  2B49 A;  1T4J A;  3LJS A;  1XXV A;  1RK2 A;  1RFT A;  4AZ1 A;  2JJD A;  3I80 A;  2XJA A;  3D1H A;  4Y2E A;  4WU3 A;  2G6Z A;  2I6M A;  4ERC A;  2CJZ A;  2I5X A;  1Q6M A;  2BGD A;  4NWG A;  1JXH A;  3FHY A;  2NT2 A;  1YHJ A;  2VAR A;  1W78 A;  3ZS7 A;  4EBU A;  1FPZ A;  5M43 A;  2AA0 A;  4ZRT A;  3MOW A;  3RRJ A;  1BZJ A;  3N0A A;  4R0S A;  1KO7 A;  1G1F A;  1Q6N A;  2IMG A;  2R3B A;  2QCJ A;  3QCE A;  1JBW A;  4DU5 A;  3B1O A;  2AX3 A;  4EN4 A;  3CM3 A;  4H34 A;  3EMU A;  2AFB A;  2J17 A;  1XXP A;  3DZV A;  4GE6 A;  2I6P A;  4GE5 A;  1ONY A;  3IQ0 A;  2MBC A;  2SHP A;  1P15 A;  4OHL A;  3ZM5 A;  4S1I B;  3RTE A;  3QKQ A;  1U25 A;  4JNB A;  3UBO A;  1WRM A;  4ICZ A;  1L2L A;  2GC5 A;  1JBV A;  5A5F A;  3L31 A;  3U96 A;  3RTC A;  2HNQ A;  3O3L A;  2JG1 A;  3ZM6 A;  3MVN A;  1XRI A;  3V0H A;  4QF5 A;  2PKM A;  1E0D A;  4QUN A;  1UAG A;  2GCA A;  1WYE A;  2Q47 A;  2HC1 A;  2CM7 A;  2JGV A;  3VAQ A;  2QDC A;  3MBH A;  5K22 A;  3MBJ A;  3S4O A;  3QCF A;  2I42 A;  3QCG A;  4RH9 A;  4JJP A;  2PKN A;  1YN9 A;  1EKK A;  2VTE A;  4HRF A;  4JKU A;  2JFF A;  1ONZ A;  1LIO A;  3CQD A;  3RQ5 A;  2I6O A;  1PYN A;  3EB1 A;  4CVM A;  3KZH A;  1X24 A;  5BX1 A;  2AM2 A;  3QKP A;  3JUL A;  2CNI A;  2XPC A;  2P4D A;  1ESJ A;  4IHF A;  4PVG A;  4S1I A;  1NMO A;  3RTB A;  3O4S A;  3F81 A;  3QCZ A;  3AWG A;  5CGA A;  4UAG A;  5IBS A;  1KNX A;  2AZR A;  5BZX A;  2CM3 A;  4JMK A;  3RQH A;  3RQ8 A;  5BYC A;  3L2B A;  3M4U A;  3LKI A;  2X5O A;  4RI4 A;  3K5W A;  2I6B A;  5F0Z A;  4N09 A;  1LIJ A;  3V0G A;  4Y14 A;  4LBX A;  2QHP A;  1NL9 A;  5C3Z A;  4DGP A;  3QCL A;  2PKF A;  1U24 A;  1OEO X;  1YGK A;  3KTN A;  4R30 A;  3Q92 A;  1NO6 A;  5KA9 A;  1L8K A;  2NLK A;  1L8G A;  4XCK A;  3NM1 A;  2DCN A;  4C5K A;  1TYY A;  2YYB A;  2I1Y A;  1O5Z A;  2BIJ A;  3QCH A;  1G7G A;  3RU3 A;  1PA9 A;  2AWD A;  1MKP A;  4NYH A;  1GWZ A;  3LJ8 A;  5BYF A;  3F99 A;  4CVL A;  1ZZW A;  4IWM A;  3UQ6 A;  1QXK A;  1NMP A;  2I4H A;  3RSQ A;  4QAH A;  2C46 A;  1ZCK A;  2GP0 A;  2I3R A;  2VEW A;  3RQQ A;  2QBQ A;  5EHP A;  1GG4 A;  3IN1 A;  2BZL A;  4ZN5 A;  2ABS A;  2CNE A;  3RGQ A;  3RU2 A;  4GFU A;  4C5J A;  4OHH A;  3QAI A;  2HVL A;  5HDE A;  2I75 A;  4B8S A;  1KAV A;  3NL5 A;  1ZCL A;  4IHH A;  2I4E A;  3OLR A;  1NNY A;  2VEV A;  1YTS A;  3B1R A;  2QDP A;  3RGO A;  4LBG A;  1OEU A;  2VTD A;  2I6J A;  2VOS A;  4C12 A;  3KD6 A;  4KAD A;  5C41 A;  4IWG A;  1Q1M A;  4OHE A;  2C49 A;  1RKD A;  5KA8 A;  1FPR A;  4I8N A;  2NTA A;  5CM5 A;  3Q1Y A;  3D42 A;  2I5B A;  1LII A;  3NBV A;  4WJM A;  1C85 A;  3RTD A;  4HV4 A;  2F71 A;  3FHX A;  2F02 A;  2Y96 A;  5A5E A;  1PXH A;  4KYQ A;  1A5Y A;  4JBC A;  4OHD A;  4QBW A;  3IE7 A;  3RTG A;  5KA4 A;  3S3K A;  2CMC A;  1PTY A;  3RZ2 A;  1EEO A;  1GQT A;  2C4E A;  3GO7 A;  3GO6 A;  2CMA A;  2G59 A;  2JG5 A;  2NV5 A;  2VEX A;  1WAX A;  2VOR A;  1YGU A;  4J51 A;  1PTT A;  3RSF A;  3PZS A;  2UUO A;  2YXU A;  5KA1 A;  3QCK A;  1EKQ A;  4YR8 B;  1NWE A;  1YTN A;  3QCN A;  3NC9 A;  3UMO A;  1EEN A;  1PTV A;  2R3E A;  2QDM A;  2DDM A;  2XTB A;  5EY7 A;  3B7O A;  5EHR A;  2ABQ A;  2FYW A;  2F6Y A;  2H04 A;  3NL3 A;  3I3Y A;  3BLU A;  3WSG A;  2WTZ A;  2BGE A;  3RSS A;  3O4U A;  3BGK A;  2HW1 A;  3WSH A;  3GXH A;  5F11 A;  4GRZ A;  3UAG A;  1RFV A;  4ZI4 A;  2HB1 A;  3NM3 A;  4K8C A;  4QDI A;  3QCD A;  2F6Z A;  2Q05 A;  2A8B A;  3S4E A;  4D3R A;  1G1H A;  1YZ4 A;  4KI9 A;  4TVV A;  2H02 A;  3ZV2 A;  4WTY A;  2B4O A;  2H4G A;  2B4U A;  1TD2 A;  2C7S A;  1Q6P A;  2OZ5 A;  3WSE A;  5TQI A;  2HCM A;  2Q5R A;  2J16 B;  3H49 A;  3D9C A;  3UMP A;  3N1C A;  3V0J A;  1YWF A;  3UQD A; 
#chains in the Genus database with same CATH homology
 1W7K A;  3EH0 A;  1O5Z A;  4BUC A;  2XJA A;  2IUA A;  4ZIY A;  2JFH A;  4CVL A;  1P3D A;  4BUB A;  1W78 A;  3N2A A;  3LK7 A;  1J6U A;  3NRS A;  1GQY A;  1GG4 A;  3PMO A;  1JBW A;  4E75 A;  4IHH A;  3ZM5 A;  2VTD A;  2VOS A;  4C12 A;  2GC5 A;  1JBV A;  1EEH A;  5A5F A;  2WJP A;  2Y1O A;  3HN7 A;  3ZM6 A;  3MVN A;  2IU9 A;  4QF5 A;  1E0D A;  1UAG A;  2GCA A;  4HV4 A;  5A5E A;  4E79 A;  2GCB A;  2VTE A;  2JFF A;  2VOR A;  2UUO A;  4CVM A;  2F00 A;  2GC6 A;  1GQQ A;  2AM2 A;  2XPC A;  4IHF A;  2AM1 A;  3EAG A;  1E8C A;  3QCZ A;  2WTZ A;  1P31 A;  4UAG A;  2Y66 A;  3PYZ A;  3UAG A;  2Y68 A;  1FGS A;  4QDI A;  4C13 A;  2X5O A;  2UUP A;  2JFG A;  3ZL8 A;  4CVK A;  2UAG A;  4IHG A;  2Y67 A;  2IU8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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