1RGRA

Cyclic peptides targeting pdz domains of psd-95: structural basis for enhanced affinity and enzymatic stability
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
93
structure length
93
Chain Sequence
EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Targeting Specific PDZ Domains of PSD-95; Structural Basis for Enhanced Affinity and Enzymatic Stability of a Cyclic Peptide.
pubmed doi rcsb
molecule tags Structural protein/de novo protein
source organism Rattus norvegicus
molecule keywords Presynaptic density protein 95
total genus 17
structure length 93
sequence length 93
ec nomenclature
pdb deposition date 2003-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00595 PDZ PDZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.42.10 Mainly Beta Roll Pdz3 Domain Pdz3 Domain 1rgrA00
2VPHA 3I4WA 2CSSA 2I1NA 1GM1A 3HVQC 1QAUA 2FCFA 3GGEA 3K1RA 2VRFA 3GDSA 1Z86A 2EDZA 1FC7A 1K32A 4GVCA 4NMRA 4UU6A 1VCWA 5G1DA 5GLJA 3CH8A 4P2AB 1BE9A 2KPKA 3TMHA 2M10A 2JXOA 2Q9VA 3QE1A 5E6PB 1I16A 2QKUA 4Q2QA 3EGGC 2EGNA 1GQ4A 2G2LA 2IWQA 2KQFA 1NF3C 3JXTA 3EGHC 2AWUA 2JREA 1N7FA 3RL8A 4Z8JA 1YBOA 2KG2A 4Q6HA 3NFLA 4OEPA 5EZ0A 1N7EA 1UJUA 1U37A 2W4FA 3DIWA 3DJ3A 5H3JA 1N7TA 3GDUA 2D90A 2DLUA 2QKVA 2REYA 4HOPA 4L8NA 3VQFA 2JWEA 5HF4A 2OZFA 1ZUBA 4R2ZA 4Q2OA 1SOTA 1PDRA 5F67A 2DLSA 3OTPA 4E34A 1UEQA 1WHAA 1U39A 2DJTA 3KZDA 1Q7XA 4Q2PA 3R69A 2EEHA 2EJYA 1UM1A 2KJPA 1UM7A 4Q2NA 2I0IA 2Z17A 1TP5A 3QGLA 4WYUA 3CBXA 3QJMA 1N6FA 2QBWA 3RL7A 2YT7A 2G5MB 2M0ZA 3NGHA 1VA8A 2IWPA 3PDZA 1RGRA 3QIKA 2I4SA 1N6EA 1Y7NA 2AWXA 4NMVA 1RY4A 3OU0A 1KWAA 4NNLA 2M0VA 2VWRA 3ZRTA 2H3MA 2ZPLA 4JOHA 2K20A 1WF7A 1W9EA 2L4SA 1WH1A 2EGOA 2CS5A 5HFEA 1R6JA 4JL7A 4HOPB 5E11A 4UU5A 2EXGA 4JOEA 2DKRA 1X6DA 1U3BA 2EAQA 3DORA 1W9OA 4OAJA 1FC6A 3L4FD 4NMPA 5I7ZA 3O5NA 2MX6A 2VSPA 1Z87A 3GCNA 2LUIA 1IU2A 5HFCA 5FB8C 2EEGA 4JOPA 2IWNA 2OS6A 5GNDA 2L4TA 4Q6SA 2E7KA 2I04A 3K82A 4E35A 2EEIA 2W7RA 2M0TA 5HFFA 4NMSA 2X7ZA 4WYTA 3ID4A 3KZEA 5D13A 2RRMA 3MH7A 4PQWA 2KJKA 3KHFA 2DMZA 4NMOA 1N99A 4JOGA 3R0HA 2EEJA 2VSVA 4KFVA 4OEOA 1X5NA 2DB5A 3CS0A 2R4HA 4NXQA 2M0UA 3TSWA 1Q3OA 5HDYA 4NXRA 1TP3A 2CSJA 3I18A 1MFLA 4GVDA 3MH6A 1GQ5A 1WG6A 4H11A 2KBSA 2OQSA 1UJDA 2DC2A 4NXPA 1MFGA 2YUBA 1WHDA 2FN5A 1XZ9A 2KAWA 4K6YA 2PNTA 1Q3PA 1UJVA 5FHTA 2ENOA 3RLEA 1UF1A 3PV5A 2JILA 1WFGA 4GHNA 5DTHA 1V62A 2BYGA 4FGMA 3CBZA 2JINA 3NFKA 3TSVA 2V90A 1V5QA 3CBYA 1OBZA 2F0AA 3DJAA 1UITA 2YUYA 1M5ZA 5HEBA 1V1TA 3I1EA 1VB7A 2JIKA 2KOMA 2I0LA 1OZIA 2ZPMA 1WJLA 2I6VA 2KA9A 2VZ5A 3BPUA 3VQGA 1V5LA 4NMTA 3WKLA 1QAVA 3PV4A 1TQ3A 2HGAA 2O2TA 1I92A 2EDVA 3MH4A 2P3WA 3PS4A 2H2CA 1T2MA 4EDJA 1Y8TA 2KV8A 2JOAA 2FNEA 2QG1A 4KFWA 1V6BA 3FY5A 2F5YA 1FC9A 2OPGA 2Q3GA 3SHWA 5EYZA 2KYLA 2MHOA 3QJNA 2LC6A 5HETA 1X8SA 1U38A 4Q3HA 1UEPA 4YDPA 4G69A 1SOZA 2LOBA 4K72A 2KOJA 1QLCA 1L6OA 1UEZA 1VAEA 2LC7A 2D8IA 2Z9IA 2YT8A 3PDVA 2AINA 1WF8A 1WIFA 5B6LA 2H3LA 2RCZA 1FCFA 3WKMA 1ZOKA 2KOHA 5G1EA 4IC6A 4JORA 4RI0A 2HE4A 3TSZA 4F8KA 2WL7A 3GCOA 3QDOA 5A2PA 2AWWA 5JXBA 4E3BA 2PKUA 1QAVB 1LCYA 4O06A 3SOEA 2DAZA 5E22A 2QT5A 2PZDA 1UEWA 3GDVA 2D92A 3ID3A 5E21A 3QO6A 5F3XA 4MPAA 1P1DA 2OMJA 5HFBA 1D5GA 2UZCA 3E17A 2FE5A 1WI4A 2OSGA 1N6DA 5E1YA 1VJ6A 1X5RA 4K75A 5HEDA 2LA8A 3LNXA 2H2BA 2M3MA 1IU0A 1KEFA 1NTEA 4REYA 4AMHA 2OGPA 3STJA 1IHJA 3HPMA 3B76A 1OBXA 1KY9A 3R68A 4LMMA 3DJ1A 1X45A 1B8QA 2IWOA 4YYXA 2KJDA 2HE2A 4K76A 2EHRA 1WFVA 2KL1A 1UFXA 3AXAA 3PV2A 1RZXA 2PKTA 4NNMA 3CC0A 5HF1A 1G9OA 2QKTA 2YTWA 1UHPA 1X5QA 5HEYA 3CYYA 4XHVA 3SFJA 1P1EA 3SHUA 2R3YA 3K50A 2EV8A 2PA1A 4Z33A 3O46A 2K1ZA 1W9QA 2V1WA 5HJ1A 3GSLA 2GZVA 4JOKA 3ID2A 5HFDA 2EDPA 4JOFA 4JOJA 3HPKA 1WI2A 2KRGA 2EGKA 2DM8A 3SUZA 1TE0A 2L97A 4P0CA 3ID1A 2OCSA 4N6XA 1OBYA 2PDZA 2KPLA 1RGWA 1MC7A 3LNYA 4K78A 1BFEA 4NMQA 3GJ9A
chains in the Genus database with same CATH superfamily
2VPHA 3I4WA 2CSSA 2I1NA 1GM1A 3HVQC 1QAUA 2FCFA 3GGEA 3K1RA 2VRFA 3GDSA 1Z86A 2EDZA 1FC7A 1K32A 4GVCA 4NMRA 4UU6A 1VCWA 5G1DA 5GLJA 3CH8A 4P2AB 1BE9A 2KPKA 3TMHA 2M10A 2JXOA 2Q9VA 3QE1A 5E6PB 1I16A 1X9ZA 2QKUA 4Q2QA 3EGGC 2EGNA 1GQ4A 2G2LA 2IWQA 2KQFA 1NF3C 3JXTA 3EGHC 2AWUA 2JREA 1N7FA 3RL8A 4Z8JA 1YBOA 2KG2A 4Q6HA 3NFLA 4OEPA 5EZ0A 1N7EA 1UJUA 1U37A 4JJ0A 2W4FA 3DIWA 3DJ3A 5H3JA 1N7TA 3GDUA 2D90A 2DLUA 2QKVA 2REYA 4HOPA 4L8NA 3VQFA 2JWEA 5HF4A 2OZFA 1ZUBA 4R2ZA 4Q2OA 3KDKA 1SOTA 1PDRA 5F67A 2DLSA 3OTPA 4E34A 1UEQA 1WHAA 1U39A 2DJTA 3KZDA 1Q7XA 4Q2PA 3R69A 2EEHA 2EJYA 1UM1A 2KJPA 1UM7A 4Q2NA 2I0IA 2Z17A 1TP5A 3QGLA 4WYUA 3CBXA 3QJMA 1N6FA 2QBWA 3RL7A 2YT7A 2G5MB 2M0ZA 3NGHA 1VA8A 2IWPA 3PDZA 1RGRA 3QIKA 2I4SA 1N6EA 1Y7NA 2AWXA 4NMVA 1RY4A 3OU0A 1KWAA 4NNLA 2M0VA 2VWRA 3ZRTA 2H3MA 2ZPLA 4JOHA 2K20A 1WF7A 1W9EA 2L4SA 1WH1A 2EGOA 2CS5A 5HFEA 1R6JA 4JL7A 4HOPB 5E11A 4UU5A 2EXGA 4JOEA 2DKRA 1X6DA 1U3BA 2EAQA 3DORA 1W9OA 4OAJA 1FC6A 3L4FD 4NMPA 5I7ZA 3O5NA 2MX6A 2VSPA 1Z87A 3GCNA 2LUIA 1IU2A 5HFCA 5FB8C 2EEGA 4JOPA 2IWNA 2OS6A 5GNDA 2L4TA 4Q6SA 2E7KA 2I04A 3K82A 4E35A 2EEIA 2W7RA 2M0TA 5HFFA 4NMSA 2X7ZA 4WYTA 3ID4A 3KZEA 5D13A 2RRMA 3MH7A 4PQWA 2KJKA 5IL9A 3KHFA 2DMZA 3GABA 4NMOA 1N99A 4JJ3A 4FLNA 4JOGA 3R0HA 2EEJA 2VSVA 4KFVA 4OEOA 1X5NA 3KDGA 2DB5A 3CS0A 2R4HA 4NXQA 2M0UA 3TSWA 1Q3OA 5HDYA 4NXRA 1TP3A 2CSJA 3I18A 1MFLA 4GVDA 3MH6A 1GQ5A 1WG6A 4H11A 2KBSA 2OQSA 1UJDA 2DC2A 4NXPA 1MFGA 2YUBA 1WHDA 2FN5A 1XZ9A 2KAWA 4K6YA 2PNTA 1Q3PA 1UJVA 5FHTA 2ENOA 3RLEA 1UF1A 3PV5A 2JILA 1WFGA 4GHNA 5DTHA 1V62A 2BYGA 4FGMA 3CBZA 2JINA 3NFKA 3TSVA 2V90A 1V5QA 3CBYA 1OBZA 2F0AA 3DJAA 1UITA 2YUYA 1M5ZA 5HEBA 1V1TA 3I1EA 1VB7A 2JIKA 2KOMA 2I0LA 1OZIA 2ZPMA 1WJLA 2I6VA 2KA9A 5B42A 2VZ5A 3BPUA 3VQGA 1V5LA 4NMTA 3WKLA 1QAVA 3PV4A 1TQ3A 2HGAA 2O2TA 1I92A 2EDVA 3MH4A 2P3WA 3PS4A 2H2CA 1T2MA 4EDJA 1Y8TA 2KV8A 2JOAA 2FNEA 2QG1A 4KFWA 1V6BA 3FY5A 2F5YA 1FC9A 2OPGA 2Q3GA 3SHWA 5EYZA 2KYLA 2MHOA 3QJNA 2LC6A 5HETA 1X8SA 1U38A 4Q3HA 1UEPA 4YDPA 2GEFA 4G69A 1SOZA 2LOBA 4K72A 2KOJA 1QLCA 1L6OA 1UEZA 1VAEA 2LC7A 2D8IA 2Z9IA 2YT8A 3PDVA 2AINA 1WF8A 1WIFA 5B6LA 2H3LA 2RCZA 1FCFA 3WKMA 1ZOKA 2KOHA 5G1EA 4IC6A 4JORA 4RI0A 2HE4A 3TSZA 4F8KA 2WL7A 3GCOA 3QDOA 5A2PA 2AWWA 5JXBA 4E3BA 2PKUA 1QAVB 1LCYA 4O06A 3SOEA 2DAZA 5E22A 2QT5A 2PZDA 1UEWA 3GDVA 2D92A 3ID3A 5E21A 3QO6A 5F3XA 4MPAA 1P1DA 2OMJA 5HFBA 1D5GA 2UZCA 3E17A 2FE5A 1WI4A 2OSGA 1N6DA 5E1YA 2JSNA 1VJ6A 1X5RA 4K75A 5HEDA 2LA8A 3LNXA 2H2BA 2M3MA 1IU0A 1KEFA 1NTEA 4REYA 4AMHA 2OGPA 3STJA 1IHJA 3HPMA 3B76A 1OBXA 1KY9A 3R68A 4LMMA 3DJ1A 1X45A 1B8QA 2IWOA 4YYXA 2KJDA 5ILBA 2HE2A 4K76A 2EHRA 1WFVA 2KL1A 1UFXA 3AXAA 3PV2A 1RZXA 2PKTA 4NNMA 3CC0A 5HF1A 1G9OA 2QKTA 2YTWA 1UHPA 1X5QA 5HEYA 3CYYA 4XHVA 3SFJA 1P1EA 3SHUA 2R3YA 3K50A 2EV8A 2PA1A 4Z33A 3O46A 2K1ZA 1W9QA 2V1WA 5HJ1A 3GSLA 2GZVA 4JOKA 3ID2A 5HFDA 2EDPA 4JOFA 4JOJA 3HPKA 1WI2A 2KRGA 2EGKA 2DM8A 3SUZA 1TE0A 2L97A 4P0CA 3ID1A 2OCSA 3NCVA 4N6XA 1OBYA 2PDZA 2KPLA 1RGWA 1MC7A 3LNYA 4K78A 1BFEA 4NMQA 3GJ9A
chains in the Genus database with same CATH topology
2VPHA 3I4WA 2CSSA 2I1NA 1GM1A 3HVQC 1QAUA 2FCFA 3GGEA 3K1RA 2VRFA 3GDSA 1Z86A 2EDZA 1FC7A 1K32A 4GVCA 4NMRA 4UU6A 1VCWA 5G1DA 5GLJA 3CH8A 4P2AB 1BE9A 2KPKA 3TMHA 2M10A 2JXOA 2Q9VA 3QE1A 5E6PB 1I16A 1X9ZA 2QKUA 4Q2QA 3EGGC 2EGNA 1GQ4A 2G2LA 2IWQA 2KQFA 1NF3C 3JXTA 3EGHC 2AWUA 2JREA 1N7FA 3RL8A 4Z8JA 1YBOA 2KG2A 4Q6HA 3NFLA 4OEPA 5EZ0A 1N7EA 1UJUA 1U37A 4JJ0A 2W4FA 3DIWA 3DJ3A 5H3JA 1N7TA 3GDUA 2D90A 2DLUA 2QKVA 2REYA 4HOPA 4L8NA 3VQFA 2JWEA 5HF4A 2OZFA 1ZUBA 4R2ZA 4Q2OA 3KDKA 1SOTA 1PDRA 5F67A 2DLSA 3OTPA 4E34A 1UEQA 1WHAA 1U39A 2DJTA 3KZDA 1Q7XA 4Q2PA 3R69A 2EEHA 2EJYA 1UM1A 2KJPA 1UM7A 4Q2NA 2I0IA 2Z17A 1TP5A 3QGLA 4WYUA 3CBXA 3QJMA 1N6FA 2QBWA 3RL7A 2YT7A 2G5MB 2M0ZA 3NGHA 1VA8A 2IWPA 3PDZA 1RGRA 3QIKA 2I4SA 1N6EA 1Y7NA 2AWXA 4NMVA 1RY4A 3OU0A 1KWAA 4NNLA 2M0VA 2VWRA 3ZRTA 2H3MA 2ZPLA 4JOHA 2K20A 1WF7A 1W9EA 2L4SA 1WH1A 2EGOA 2CS5A 5HFEA 1R6JA 4JL7A 4HOPB 5E11A 4UU5A 2EXGA 4JOEA 2DKRA 1X6DA 1U3BA 2EAQA 3DORA 1W9OA 4OAJA 1FC6A 3L4FD 4NMPA 5I7ZA 3O5NA 2MX6A 2VSPA 1Z87A 3GCNA 2LUIA 1IU2A 5HFCA 5FB8C 2EEGA 4JOPA 2IWNA 2OS6A 5GNDA 2L4TA 4Q6SA 2E7KA 2I04A 3K82A 4E35A 2EEIA 2W7RA 2M0TA 5HFFA 4NMSA 2X7ZA 4WYTA 3ID4A 3KZEA 5D13A 2RRMA 3MH7A 4PQWA 2KJKA 5IL9A 3KHFA 2DMZA 3GABA 4NMOA 1N99A 4JJ3A 4FLNA 4JOGA 3R0HA 2EEJA 2VSVA 4KFVA 4OEOA 1X5NA 3KDGA 2DB5A 3CS0A 2R4HA 4NXQA 2M0UA 3TSWA 1Q3OA 5HDYA 4NXRA 1TP3A 2CSJA 3I18A 1MFLA 4GVDA 3MH6A 1GQ5A 1WG6A 4H11A 2KBSA 2OQSA 1UJDA 2DC2A 4NXPA 1MFGA 2YUBA 1WHDA 2FN5A 1XZ9A 2KAWA 4K6YA 2PNTA 1Q3PA 1UJVA 5FHTA 2ENOA 3RLEA 1UF1A 3PV5A 2JILA 1WFGA 4GHNA 5DTHA 1V62A 2BYGA 4FGMA 3CBZA 2JINA 3NFKA 3TSVA 2V90A 1V5QA 3CBYA 1OBZA 2F0AA 3DJAA 1UITA 2YUYA 1M5ZA 5HEBA 1V1TA 3I1EA 1VB7A 2JIKA 2KOMA 2I0LA 1OZIA 2ZPMA 1WJLA 2I6VA 2KA9A 5B42A 2VZ5A 3BPUA 3VQGA 1V5LA 4NMTA 3WKLA 1QAVA 3PV4A 1TQ3A 2HGAA 2O2TA 1I92A 2EDVA 3MH4A 2P3WA 3PS4A 2H2CA 1T2MA 4EDJA 1Y8TA 2KV8A 2JOAA 2FNEA 2QG1A 4KFWA 1V6BA 3FY5A 2F5YA 1FC9A 2OPGA 2Q3GA 3SHWA 5EYZA 2KYLA 2MHOA 3QJNA 2LC6A 5HETA 1X8SA 1U38A 4Q3HA 1UEPA 4YDPA 2GEFA 4G69A 1SOZA 2LOBA 4K72A 2KOJA 1QLCA 1L6OA 1UEZA 1VAEA 2LC7A 2D8IA 2Z9IA 2YT8A 3PDVA 2AINA 1WF8A 1WIFA 5B6LA 2H3LA 2RCZA 1FCFA 3WKMA 1ZOKA 2KOHA 5G1EA 4IC6A 4JORA 4RI0A 2HE4A 3TSZA 4F8KA 2WL7A 3GCOA 3QDOA 5A2PA 2AWWA 5JXBA 4E3BA 2PKUA 1QAVB 1LCYA 4O06A 3SOEA 2DAZA 5E22A 2QT5A 2PZDA 1UEWA 3GDVA 2D92A 3ID3A 5E21A 3QO6A 5F3XA 4MPAA 1P1DA 2OMJA 5HFBA 1D5GA 2UZCA 3E17A 2FE5A 1WI4A 2OSGA 1N6DA 5E1YA 2JSNA 1VJ6A 1X5RA 4K75A 5HEDA 2LA8A 3LNXA 2H2BA 2M3MA 1IU0A 1KEFA 1NTEA 4REYA 4AMHA 2OGPA 3STJA 1IHJA 3HPMA 3B76A 1OBXA 1KY9A 3R68A 4LMMA 3DJ1A 1X45A 1B8QA 2IWOA 4YYXA 2KJDA 5ILBA 2HE2A 4K76A 2EHRA 1WFVA 2KL1A 1UFXA 3AXAA 3PV2A 1RZXA 2PKTA 4NNMA 3CC0A 5HF1A 1G9OA 2QKTA 2YTWA 1UHPA 1X5QA 5HEYA 3CYYA 4XHVA 3SFJA 1P1EA 3SHUA 2R3YA 3K50A 2EV8A 2PA1A 4Z33A 3O46A 2K1ZA 1W9QA 2V1WA 5HJ1A 3GSLA 2GZVA 4JOKA 3ID2A 5HFDA 2EDPA 4JOFA 4JOJA 3HPKA 1WI2A 2KRGA 2EGKA 2DM8A 3SUZA 1TE0A 2L97A 4P0CA 3ID1A 2OCSA 3NCVA 4N6XA 1OBYA 2PDZA 2KPLA 1RGWA 1MC7A 3LNYA 4K78A 1BFEA 4NMQA 3GJ9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VPH A;  3I4W A;  2CSS A;  2I1N A;  1GM1 A;  3HVQ C;  1QAU A;  2FCF A;  3GGE A;  3K1R A;  2VRF A;  3GDS A;  1Z86 A;  2EDZ A;  1FC7 A;  1K32 A;  4GVC A;  4NMR A;  4UU6 A;  1VCW A;  5G1D A;  5GLJ A;  3CH8 A;  4P2A B;  1BE9 A;  2KPK A;  3TMH A;  2M10 A;  2JXO A;  2Q9V A;  3QE1 A;  5E6P B;  1I16 A;  2QKU A;  4Q2Q A;  3EGG C;  2EGN A;  1GQ4 A;  2G2L A;  2IWQ A;  2KQF A;  1NF3 C;  3JXT A;  3EGH C;  2AWU A;  2JRE A;  1N7F A;  3RL8 A;  4Z8J A;  1YBO A;  2KG2 A;  4Q6H A;  3NFL A;  4OEP A;  5EZ0 A;  1N7E A;  1UJU A;  1U37 A;  2W4F A;  3DIW A;  3DJ3 A;  5H3J A;  1N7T A;  3GDU A;  2D90 A;  2DLU A;  2QKV A;  2REY A;  4HOP A;  4L8N A;  3VQF A;  2JWE A;  5HF4 A;  2OZF A;  1ZUB A;  4R2Z A;  4Q2O A;  1SOT A;  1PDR A;  5F67 A;  2DLS A;  3OTP A;  4E34 A;  1UEQ A;  1WHA A;  1U39 A;  2DJT A;  3KZD A;  1Q7X A;  4Q2P A;  3R69 A;  2EEH A;  2EJY A;  1UM1 A;  2KJP A;  1UM7 A;  4Q2N A;  2I0I A;  2Z17 A;  1TP5 A;  3QGL A;  4WYU A;  3CBX A;  3QJM A;  1N6F A;  2QBW A;  3RL7 A;  2YT7 A;  2G5M B;  2M0Z A;  3NGH A;  1VA8 A;  2IWP A;  3PDZ A;  1RGR A;  3QIK A;  2I4S A;  1N6E A;  1Y7N A;  2AWX A;  4NMV A;  1RY4 A;  3OU0 A;  1KWA A;  4NNL A;  2M0V A;  2VWR A;  3ZRT A;  2H3M A;  2ZPL A;  4JOH A;  2K20 A;  1WF7 A;  1W9E A;  2L4S A;  1WH1 A;  2EGO A;  2CS5 A;  5HFE A;  1R6J A;  4JL7 A;  4HOP B;  5E11 A;  4UU5 A;  2EXG A;  4JOE A;  2DKR A;  1X6D A;  1U3B A;  2EAQ A;  3DOR A;  1W9O A;  4OAJ A;  1FC6 A;  3L4F D;  4NMP A;  5I7Z A;  3O5N A;  2MX6 A;  2VSP A;  1Z87 A;  3GCN A;  2LUI A;  1IU2 A;  5HFC A;  5FB8 C;  2EEG A;  4JOP A;  2IWN A;  2OS6 A;  5GND A;  2L4T A;  4Q6S A;  2E7K A;  2I04 A;  3K82 A;  4E35 A;  2EEI A;  2W7R A;  2M0T A;  5HFF A;  4NMS A;  2X7Z A;  4WYT A;  3ID4 A;  3KZE A;  5D13 A;  2RRM A;  3MH7 A;  4PQW A;  2KJK A;  3KHF A;  2DMZ A;  4NMO A;  1N99 A;  4JOG A;  3R0H A;  2EEJ A;  2VSV A;  4KFV A;  4OEO A;  1X5N A;  2DB5 A;  3CS0 A;  2R4H A;  4NXQ A;  2M0U A;  3TSW A;  1Q3O A;  5HDY A;  4NXR A;  1TP3 A;  2CSJ A;  3I18 A;  1MFL A;  4GVD A;  3MH6 A;  1GQ5 A;  1WG6 A;  4H11 A;  2KBS A;  2OQS A;  1UJD A;  2DC2 A;  4NXP A;  1MFG A;  2YUB A;  1WHD A;  2FN5 A;  1XZ9 A;  2KAW A;  4K6Y A;  2PNT A;  1Q3P A;  1UJV A;  5FHT A;  2ENO A;  3RLE A;  1UF1 A;  3PV5 A;  2JIL A;  1WFG A;  4GHN A;  5DTH A;  1V62 A;  2BYG A;  4FGM A;  3CBZ A;  2JIN A;  3NFK A;  3TSV A;  2V90 A;  1V5Q A;  3CBY A;  1OBZ A;  2F0A A;  3DJA A;  1UIT A;  2YUY A;  1M5Z A;  5HEB A;  1V1T A;  3I1E A;  1VB7 A;  2JIK A;  2KOM A;  2I0L A;  1OZI A;  2ZPM A;  1WJL A;  2I6V A;  2KA9 A;  2VZ5 A;  3BPU A;  3VQG A;  1V5L A;  4NMT A;  3WKL A;  1QAV A;  3PV4 A;  1TQ3 A;  2HGA A;  2O2T A;  1I92 A;  2EDV A;  3MH4 A;  2P3W A;  3PS4 A;  2H2C A;  1T2M A;  4EDJ A;  1Y8T A;  2KV8 A;  2JOA A;  2FNE A;  2QG1 A;  4KFW A;  1V6B A;  3FY5 A;  2F5Y A;  1FC9 A;  2OPG A;  2Q3G A;  3SHW A;  5EYZ A;  2KYL A;  2MHO A;  3QJN A;  2LC6 A;  5HET A;  1X8S A;  1U38 A;  4Q3H A;  1UEP A;  4YDP A;  4G69 A;  1SOZ A;  2LOB A;  4K72 A;  2KOJ A;  1QLC A;  1L6O A;  1UEZ A;  1VAE A;  2LC7 A;  2D8I A;  2Z9I A;  2YT8 A;  3PDV A;  2AIN A;  1WF8 A;  1WIF A;  5B6L A;  2H3L A;  2RCZ A;  1FCF A;  3WKM A;  1ZOK A;  2KOH A;  5G1E A;  4IC6 A;  4JOR A;  4RI0 A;  2HE4 A;  3TSZ A;  4F8K A;  2WL7 A;  3GCO A;  3QDO A;  5A2P A;  2AWW A;  5JXB A;  4E3B A;  2PKU A;  1QAV B;  1LCY A;  4O06 A;  3SOE A;  2DAZ A;  5E22 A;  2QT5 A;  2PZD A;  1UEW A;  3GDV A;  2D92 A;  3ID3 A;  5E21 A;  3QO6 A;  5F3X A;  4MPA A;  1P1D A;  2OMJ A;  5HFB A;  1D5G A;  2UZC A;  3E17 A;  2FE5 A;  1WI4 A;  2OSG A;  1N6D A;  5E1Y A;  1VJ6 A;  1X5R A;  4K75 A;  5HED A;  2LA8 A;  3LNX A;  2H2B A;  2M3M A;  1IU0 A;  1KEF A;  1NTE A;  4REY A;  4AMH A;  2OGP A;  3STJ A;  1IHJ A;  3HPM A;  3B76 A;  1OBX A;  1KY9 A;  3R68 A;  4LMM A;  3DJ1 A;  1X45 A;  1B8Q A;  2IWO A;  4YYX A;  2KJD A;  2HE2 A;  4K76 A;  2EHR A;  1WFV A;  2KL1 A;  1UFX A;  3AXA A;  3PV2 A;  1RZX A;  2PKT A;  4NNM A;  3CC0 A;  5HF1 A;  1G9O A;  2QKT A;  2YTW A;  1UHP A;  1X5Q A;  5HEY A;  3CYY A;  4XHV A;  3SFJ A;  1P1E A;  3SHU A;  2R3Y A;  3K50 A;  2EV8 A;  2PA1 A;  4Z33 A;  3O46 A;  2K1Z A;  1W9Q A;  2V1W A;  5HJ1 A;  3GSL A;  2GZV A;  4JOK A;  3ID2 A;  5HFD A;  2EDP A;  4JOF A;  4JOJ A;  3HPK A;  1WI2 A;  2KRG A;  2EGK A;  2DM8 A;  3SUZ A;  1TE0 A;  2L97 A;  4P0C A;  3ID1 A;  2OCS A;  4N6X A;  1OBY A;  2PDZ A;  2KPL A;  1RGW A;  1MC7 A;  3LNY A;  4K78 A;  1BFE A;  4NMQ A;  3GJ9 A; 
#chains in the Genus database with same CATH topology
 2VPH A;  3I4W A;  2CSS A;  2I1N A;  1GM1 A;  3HVQ C;  1QAU A;  2FCF A;  3GGE A;  3K1R A;  2VRF A;  3GDS A;  1Z86 A;  2EDZ A;  1FC7 A;  1K32 A;  4GVC A;  4NMR A;  4UU6 A;  1VCW A;  5G1D A;  5GLJ A;  3CH8 A;  4P2A B;  1BE9 A;  2KPK A;  3TMH A;  2M10 A;  2JXO A;  2Q9V A;  3QE1 A;  5E6P B;  1I16 A;  1X9Z A;  2QKU A;  4Q2Q A;  3EGG C;  2EGN A;  1GQ4 A;  2G2L A;  2IWQ A;  2KQF A;  1NF3 C;  3JXT A;  3EGH C;  2AWU A;  2JRE A;  1N7F A;  3RL8 A;  4Z8J A;  1YBO A;  2KG2 A;  4Q6H A;  3NFL A;  4OEP A;  5EZ0 A;  1N7E A;  1UJU A;  1U37 A;  4JJ0 A;  2W4F A;  3DIW A;  3DJ3 A;  5H3J A;  1N7T A;  3GDU A;  2D90 A;  2DLU A;  2QKV A;  2REY A;  4HOP A;  4L8N A;  3VQF A;  2JWE A;  5HF4 A;  2OZF A;  1ZUB A;  4R2Z A;  4Q2O A;  3KDK A;  1SOT A;  1PDR A;  5F67 A;  2DLS A;  3OTP A;  4E34 A;  1UEQ A;  1WHA A;  1U39 A;  2DJT A;  3KZD A;  1Q7X A;  4Q2P A;  3R69 A;  2EEH A;  2EJY A;  1UM1 A;  2KJP A;  1UM7 A;  4Q2N A;  2I0I A;  2Z17 A;  1TP5 A;  3QGL A;  4WYU A;  3CBX A;  3QJM A;  1N6F A;  2QBW A;  3RL7 A;  2YT7 A;  2G5M B;  2M0Z A;  3NGH A;  1VA8 A;  2IWP A;  3PDZ A;  1RGR A;  3QIK A;  2I4S A;  1N6E A;  1Y7N A;  2AWX A;  4NMV A;  1RY4 A;  3OU0 A;  1KWA A;  4NNL A;  2M0V A;  2VWR A;  3ZRT A;  2H3M A;  2ZPL A;  4JOH A;  2K20 A;  1WF7 A;  1W9E A;  2L4S A;  1WH1 A;  2EGO A;  2CS5 A;  5HFE A;  1R6J A;  4JL7 A;  4HOP B;  5E11 A;  4UU5 A;  2EXG A;  4JOE A;  2DKR A;  1X6D A;  1U3B A;  2EAQ A;  3DOR A;  1W9O A;  4OAJ A;  1FC6 A;  3L4F D;  4NMP A;  5I7Z A;  3O5N A;  2MX6 A;  2VSP A;  1Z87 A;  3GCN A;  2LUI A;  1IU2 A;  5HFC A;  5FB8 C;  2EEG A;  4JOP A;  2IWN A;  2OS6 A;  5GND A;  2L4T A;  4Q6S A;  2E7K A;  2I04 A;  3K82 A;  4E35 A;  2EEI A;  2W7R A;  2M0T A;  5HFF A;  4NMS A;  2X7Z A;  4WYT A;  3ID4 A;  3KZE A;  5D13 A;  2RRM A;  3MH7 A;  4PQW A;  2KJK A;  5IL9 A;  3KHF A;  2DMZ A;  3GAB A;  4NMO A;  1N99 A;  4JJ3 A;  4FLN A;  4JOG A;  3R0H A;  2EEJ A;  2VSV A;  4KFV A;  4OEO A;  1X5N A;  3KDG A;  2DB5 A;  3CS0 A;  2R4H A;  4NXQ A;  2M0U A;  3TSW A;  1Q3O A;  5HDY A;  4NXR A;  1TP3 A;  2CSJ A;  3I18 A;  1MFL A;  4GVD A;  3MH6 A;  1GQ5 A;  1WG6 A;  4H11 A;  2KBS A;  2OQS A;  1UJD A;  2DC2 A;  4NXP A;  1MFG A;  2YUB A;  1WHD A;  2FN5 A;  1XZ9 A;  2KAW A;  4K6Y A;  2PNT A;  1Q3P A;  1UJV A;  5FHT A;  2ENO A;  3RLE A;  1UF1 A;  3PV5 A;  2JIL A;  1WFG A;  4GHN A;  5DTH A;  1V62 A;  2BYG A;  4FGM A;  3CBZ A;  2JIN A;  3NFK A;  3TSV A;  2V90 A;  1V5Q A;  3CBY A;  1OBZ A;  2F0A A;  3DJA A;  1UIT A;  2YUY A;  1M5Z A;  5HEB A;  1V1T A;  3I1E A;  1VB7 A;  2JIK A;  2KOM A;  2I0L A;  1OZI A;  2ZPM A;  1WJL A;  2I6V A;  2KA9 A;  5B42 A;  2VZ5 A;  3BPU A;  3VQG A;  1V5L A;  4NMT A;  3WKL A;  1QAV A;  3PV4 A;  1TQ3 A;  2HGA A;  2O2T A;  1I92 A;  2EDV A;  3MH4 A;  2P3W A;  3PS4 A;  2H2C A;  1T2M A;  4EDJ A;  1Y8T A;  2KV8 A;  2JOA A;  2FNE A;  2QG1 A;  4KFW A;  1V6B A;  3FY5 A;  2F5Y A;  1FC9 A;  2OPG A;  2Q3G A;  3SHW A;  5EYZ A;  2KYL A;  2MHO A;  3QJN A;  2LC6 A;  5HET A;  1X8S A;  1U38 A;  4Q3H A;  1UEP A;  4YDP A;  2GEF A;  4G69 A;  1SOZ A;  2LOB A;  4K72 A;  2KOJ A;  1QLC A;  1L6O A;  1UEZ A;  1VAE A;  2LC7 A;  2D8I A;  2Z9I A;  2YT8 A;  3PDV A;  2AIN A;  1WF8 A;  1WIF A;  5B6L A;  2H3L A;  2RCZ A;  1FCF A;  3WKM A;  1ZOK A;  2KOH A;  5G1E A;  4IC6 A;  4JOR A;  4RI0 A;  2HE4 A;  3TSZ A;  4F8K A;  2WL7 A;  3GCO A;  3QDO A;  5A2P A;  2AWW A;  5JXB A;  4E3B A;  2PKU A;  1QAV B;  1LCY A;  4O06 A;  3SOE A;  2DAZ A;  5E22 A;  2QT5 A;  2PZD A;  1UEW A;  3GDV A;  2D92 A;  3ID3 A;  5E21 A;  3QO6 A;  5F3X A;  4MPA A;  1P1D A;  2OMJ A;  5HFB A;  1D5G A;  2UZC A;  3E17 A;  2FE5 A;  1WI4 A;  2OSG A;  1N6D A;  5E1Y A;  2JSN A;  1VJ6 A;  1X5R A;  4K75 A;  5HED A;  2LA8 A;  3LNX A;  2H2B A;  2M3M A;  1IU0 A;  1KEF A;  1NTE A;  4REY A;  4AMH A;  2OGP A;  3STJ A;  1IHJ A;  3HPM A;  3B76 A;  1OBX A;  1KY9 A;  3R68 A;  4LMM A;  3DJ1 A;  1X45 A;  1B8Q A;  2IWO A;  4YYX A;  2KJD A;  5ILB A;  2HE2 A;  4K76 A;  2EHR A;  1WFV A;  2KL1 A;  1UFX A;  3AXA A;  3PV2 A;  1RZX A;  2PKT A;  4NNM A;  3CC0 A;  5HF1 A;  1G9O A;  2QKT A;  2YTW A;  1UHP A;  1X5Q A;  5HEY A;  3CYY A;  4XHV A;  3SFJ A;  1P1E A;  3SHU A;  2R3Y A;  3K50 A;  2EV8 A;  2PA1 A;  4Z33 A;  3O46 A;  2K1Z A;  1W9Q A;  2V1W A;  5HJ1 A;  3GSL A;  2GZV A;  4JOK A;  3ID2 A;  5HFD A;  2EDP A;  4JOF A;  4JOJ A;  3HPK A;  1WI2 A;  2KRG A;  2EGK A;  2DM8 A;  3SUZ A;  1TE0 A;  2L97 A;  4P0C A;  3ID1 A;  2OCS A;  3NCV A;  4N6X A;  1OBY A;  2PDZ A;  2KPL A;  1RGW A;  1MC7 A;  3LNY A;  4K78 A;  1BFE A;  4NMQ A;  3GJ9 A; 
#chains in the Genus database with same CATH homology
 2VPH A;  3I4W A;  2CSS A;  2I1N A;  1GM1 A;  3HVQ C;  1QAU A;  2FCF A;  3GGE A;  3K1R A;  2VRF A;  3GDS A;  1Z86 A;  2EDZ A;  1FC7 A;  1K32 A;  4GVC A;  4NMR A;  4UU6 A;  1VCW A;  5G1D A;  5GLJ A;  3CH8 A;  4P2A B;  1BE9 A;  2KPK A;  3TMH A;  2M10 A;  2JXO A;  2Q9V A;  3QE1 A;  5E6P B;  1I16 A;  1X9Z A;  2QKU A;  4Q2Q A;  3EGG C;  2EGN A;  1GQ4 A;  2G2L A;  2IWQ A;  2KQF A;  1NF3 C;  3JXT A;  3EGH C;  2AWU A;  2JRE A;  1N7F A;  3RL8 A;  4Z8J A;  1YBO A;  2KG2 A;  4Q6H A;  3NFL A;  4OEP A;  5EZ0 A;  1N7E A;  1UJU A;  1U37 A;  4JJ0 A;  2W4F A;  3DIW A;  3DJ3 A;  5H3J A;  1N7T A;  3GDU A;  2D90 A;  2DLU A;  2QKV A;  2REY A;  4HOP A;  4L8N A;  3VQF A;  2JWE A;  5HF4 A;  2OZF A;  1ZUB A;  4R2Z A;  4Q2O A;  3KDK A;  1SOT A;  1PDR A;  5F67 A;  2DLS A;  3OTP A;  4E34 A;  1UEQ A;  1WHA A;  1U39 A;  2DJT A;  3KZD A;  1Q7X A;  4Q2P A;  3R69 A;  2EEH A;  2EJY A;  1UM1 A;  2KJP A;  1UM7 A;  4Q2N A;  2I0I A;  2Z17 A;  1TP5 A;  3QGL A;  4WYU A;  3CBX A;  3QJM A;  1N6F A;  2QBW A;  3RL7 A;  2YT7 A;  2G5M B;  2M0Z A;  3NGH A;  1VA8 A;  2IWP A;  3PDZ A;  1RGR A;  3QIK A;  2I4S A;  1N6E A;  1Y7N A;  2AWX A;  4NMV A;  1RY4 A;  3OU0 A;  1KWA A;  4NNL A;  2M0V A;  2VWR A;  3ZRT A;  2H3M A;  2ZPL A;  4JOH A;  2K20 A;  1WF7 A;  1W9E A;  2L4S A;  1WH1 A;  2EGO A;  2CS5 A;  5HFE A;  1R6J A;  4JL7 A;  4HOP B;  5E11 A;  4UU5 A;  2EXG A;  4JOE A;  2DKR A;  1X6D A;  1U3B A;  2EAQ A;  3DOR A;  1W9O A;  4OAJ A;  1FC6 A;  3L4F D;  4NMP A;  5I7Z A;  3O5N A;  2MX6 A;  2VSP A;  1Z87 A;  3GCN A;  2LUI A;  1IU2 A;  5HFC A;  5FB8 C;  2EEG A;  4JOP A;  2IWN A;  2OS6 A;  5GND A;  2L4T A;  4Q6S A;  2E7K A;  2I04 A;  3K82 A;  4E35 A;  2EEI A;  2W7R A;  2M0T A;  5HFF A;  4NMS A;  2X7Z A;  4WYT A;  3ID4 A;  3KZE A;  5D13 A;  2RRM A;  3MH7 A;  4PQW A;  2KJK A;  5IL9 A;  3KHF A;  2DMZ A;  3GAB A;  4NMO A;  1N99 A;  4JJ3 A;  4FLN A;  4JOG A;  3R0H A;  2EEJ A;  2VSV A;  4KFV A;  4OEO A;  1X5N A;  3KDG A;  2DB5 A;  3CS0 A;  2R4H A;  4NXQ A;  2M0U A;  3TSW A;  1Q3O A;  5HDY A;  4NXR A;  1TP3 A;  2CSJ A;  3I18 A;  1MFL A;  4GVD A;  3MH6 A;  1GQ5 A;  1WG6 A;  4H11 A;  2KBS A;  2OQS A;  1UJD A;  2DC2 A;  4NXP A;  1MFG A;  2YUB A;  1WHD A;  2FN5 A;  1XZ9 A;  2KAW A;  4K6Y A;  2PNT A;  1Q3P A;  1UJV A;  5FHT A;  2ENO A;  3RLE A;  1UF1 A;  3PV5 A;  2JIL A;  1WFG A;  4GHN A;  5DTH A;  1V62 A;  2BYG A;  4FGM A;  3CBZ A;  2JIN A;  3NFK A;  3TSV A;  2V90 A;  1V5Q A;  3CBY A;  1OBZ A;  2F0A A;  3DJA A;  1UIT A;  2YUY A;  1M5Z A;  5HEB A;  1V1T A;  3I1E A;  1VB7 A;  2JIK A;  2KOM A;  2I0L A;  1OZI A;  2ZPM A;  1WJL A;  2I6V A;  2KA9 A;  5B42 A;  2VZ5 A;  3BPU A;  3VQG A;  1V5L A;  4NMT A;  3WKL A;  1QAV A;  3PV4 A;  1TQ3 A;  2HGA A;  2O2T A;  1I92 A;  2EDV A;  3MH4 A;  2P3W A;  3PS4 A;  2H2C A;  1T2M A;  4EDJ A;  1Y8T A;  2KV8 A;  2JOA A;  2FNE A;  2QG1 A;  4KFW A;  1V6B A;  3FY5 A;  2F5Y A;  1FC9 A;  2OPG A;  2Q3G A;  3SHW A;  5EYZ A;  2KYL A;  2MHO A;  3QJN A;  2LC6 A;  5HET A;  1X8S A;  1U38 A;  4Q3H A;  1UEP A;  4YDP A;  2GEF A;  4G69 A;  1SOZ A;  2LOB A;  4K72 A;  2KOJ A;  1QLC A;  1L6O A;  1UEZ A;  1VAE A;  2LC7 A;  2D8I A;  2Z9I A;  2YT8 A;  3PDV A;  2AIN A;  1WF8 A;  1WIF A;  5B6L A;  2H3L A;  2RCZ A;  1FCF A;  3WKM A;  1ZOK A;  2KOH A;  5G1E A;  4IC6 A;  4JOR A;  4RI0 A;  2HE4 A;  3TSZ A;  4F8K A;  2WL7 A;  3GCO A;  3QDO A;  5A2P A;  2AWW A;  5JXB A;  4E3B A;  2PKU A;  1QAV B;  1LCY A;  4O06 A;  3SOE A;  2DAZ A;  5E22 A;  2QT5 A;  2PZD A;  1UEW A;  3GDV A;  2D92 A;  3ID3 A;  5E21 A;  3QO6 A;  5F3X A;  4MPA A;  1P1D A;  2OMJ A;  5HFB A;  1D5G A;  2UZC A;  3E17 A;  2FE5 A;  1WI4 A;  2OSG A;  1N6D A;  5E1Y A;  2JSN A;  1VJ6 A;  1X5R A;  4K75 A;  5HED A;  2LA8 A;  3LNX A;  2H2B A;  2M3M A;  1IU0 A;  1KEF A;  1NTE A;  4REY A;  4AMH A;  2OGP A;  3STJ A;  1IHJ A;  3HPM A;  3B76 A;  1OBX A;  1KY9 A;  3R68 A;  4LMM A;  3DJ1 A;  1X45 A;  1B8Q A;  2IWO A;  4YYX A;  2KJD A;  5ILB A;  2HE2 A;  4K76 A;  2EHR A;  1WFV A;  2KL1 A;  1UFX A;  3AXA A;  3PV2 A;  1RZX A;  2PKT A;  4NNM A;  3CC0 A;  5HF1 A;  1G9O A;  2QKT A;  2YTW A;  1UHP A;  1X5Q A;  5HEY A;  3CYY A;  4XHV A;  3SFJ A;  1P1E A;  3SHU A;  2R3Y A;  3K50 A;  2EV8 A;  2PA1 A;  4Z33 A;  3O46 A;  2K1Z A;  1W9Q A;  2V1W A;  5HJ1 A;  3GSL A;  2GZV A;  4JOK A;  3ID2 A;  5HFD A;  2EDP A;  4JOF A;  4JOJ A;  3HPK A;  1WI2 A;  2KRG A;  2EGK A;  2DM8 A;  3SUZ A;  1TE0 A;  2L97 A;  4P0C A;  3ID1 A;  2OCS A;  3NCV A;  4N6X A;  1OBY A;  2PDZ A;  2KPL A;  1RGW A;  1MC7 A;  3LNY A;  4K78 A;  1BFE A;  4NMQ A;  3GJ9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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