2EXGA

Making protein-protein interactions drugable: discovery of low-molecular-weight ligands for the af6 pdz domain
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
101
structure length
101
Chain Sequence
GPLGSLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of low-molecular-weight ligands for the AF6 PDZ domain.
pubmed doi rcsb
molecule tags Cell adhesion
source organism Homo sapiens
molecule keywords Afadin
total genus 23
structure length 101
sequence length 101
ec nomenclature
pdb deposition date 2005-11-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00595 PDZ PDZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.42.10 Mainly Beta Roll Pdz3 Domain Pdz3 Domain 2exgA00
2V1WA 4REYA 4UU5A 4P0CA 1D5GA 2KV8A 1T2MA 1Y8TA 5F67A 2M0VA 3RL7A 4Z33A 2EJYA 2WL7A 2W4FA 2YTWA 1WJLA 3PV2A 2P3WA 1IU0A 2EHRA 3LNXA 4LMMA 2H3LA 2E7KA 3BPUA 1N6FA 2PNTA 3GGEA 5HFFA 4GVDA 2ZPLA 2HE2A 2R3YA 2REYA 1GQ5A 2IWQA 1N7FA 3SHWA 1MFLA 2EDPA 4Q2OA 2DM8A 1KEFA 4P2AB 1UJUA 3B76A 1MC7A 1U38A 1WH1A 2H2BA 1QAVB 2M0TA 1UF1A 2YT7A 1OBYA 4EDJA 2KJDA 3CBXA 4PQWA 3MH6A 2KA9A 1LCYA 5HEDA 1X5RA 3GJ9A 5E1YA 3GDSA 2MHOA 3CC0A 2EV8A 2OZFA 3MH7A 1U3BA 5GNDA 5F3XA 3E17A 1N99A 3OTPA 2AWXA 2X7ZA 1RGRA 1Q3OA 3PDZA 2OQSA 2M0UA 1P1DA 2Q3GA 2KAWA 3SFJA 2FN5A 4K72A 2F5YA 3HPKA 4G69A 3PS4A 1G9OA 2KQFA 2UZCA 2KRGA 2QKVA 4NMVA 3TSZA 3ID1A 1N7TA 5A2PA 1TP5A 2EEGA 1X8SA 1SOTA 4E3BA 5HFDA 4NXQA 5B6LA 2EGOA 3O5NA 2JOAA 2EAQA 2PKTA 3ID4A 3HVQC 1FC7A 2M3MA 2ENOA 5JXBA 4KFVA 2VZ5A 4JL7A 1IU2A 1UEWA 1X45A 5I7ZA 1VJ6A 2G2LA 1UITA 5G1EA 1X5QA 4NXRA 1SOZA 1BE9A 3NFLA 1UJVA 1GQ4A 3ZRTA 1Y7NA 3QJNA 2KJPA 4NNLA 2AINA 3QO6A 4NMTA 1QAVA 3CH8A 1UEZA 4K75A 2EGNA 3O46A 1VAEA 2JWEA 1N7EA 1UM7A 2BYGA 1RZXA 4YYXA 1ZOKA 2JXOA 4JOHA 1X5NA 3OU0A 3QE1A 5DTHA 4OAJA 1PDRA 3SUZA 4R2ZA 3QGLA 3TSWA 3WKMA 1I16A 2KL1A 2KJKA 4Q6SA 3AXAA 1WHAA 2H2CA 2DKRA 3LNYA 3PV4A 2KBSA 2QBWA 2EDVA 4JOGA 1WF8A 2LC6A 2QKTA 3EGHC 2LOBA 4YDPA 4E34A 2G5MB 1UEQA 4NMPA 1WI4A 1UEPA 3DIWA 1BFEA 2R4HA 1Q7XA 2EEHA 4KFWA 4MPAA 3WKLA 4NMSA 1RGWA 3CYYA 3VQFA 4JOEA 2GZVA 1RY4A 3CS0A 5E11A 1UHPA 3NGHA 5HDYA 1K32A 1L6OA 2FNEA 4O06A 2EDZA 1V5LA 3R0HA 5HFBA 2VRFA 2YT8A 4NNMA 4Z8JA 3L4FD 4RI0A 2O2TA 3EGGC 2DJTA 2JILA 2Q9VA 4JORA 4WYUA 2LUIA 1W9EA 2HE4A 3SOEA 2VSPA 2I1NA 4Q3HA 1N6DA 2IWOA 5FB8C 4NMOA 1Z87A 2L97A 1TP3A 1VA8A 3NFKA 2PKUA 2PZDA 2OCSA 3ID2A 5E21A 3PV5A 4E35A 1WIFA 2EEJA 2DAZA 2KYLA 5H3JA 2LC7A 2JINA 4UU6A 3I1EA 3R68A 2OGPA 4JOPA 5HEYA 2EXGA 2DMZA 1WG6A 3FY5A 3TMHA 2OS6A 3KHFA 1I92A 2VSVA 3QIKA 1N6EA 1WFVA 1NTEA 2JREA 4Q2QA 3K50A 2D8IA 3DORA 1Z86A 4N6XA 4WYTA 2AWWA 1W9OA 2CS5A 1TQ3A 4HOPB 5FHTA 5GLJA 5EYZA 3CBYA 4NXPA 1VB7A 2AWUA 5D13A 1V5QA 2RRMA 2VPHA 4JOFA 2OSGA 4OEPA 5HFCA 3GCNA 2JIKA 2I6VA 3VQGA 2QKUA 1WF7A 2Z17A 2KOHA 1FC9A 3RLEA 2K1ZA 4GVCA 5G1DA 2K20A 1ZUBA 1U39A 1UFXA 1TE0A 2DLUA 2EGKA 4K78A 1V62A 2KG2A 3DJ1A 1XZ9A 3STJA 2PA1A 5E22A 1WFGA 1KY9A 2H3MA 1W9QA 3QJMA 2F0AA 2I0IA 1P1EA 2EEIA 3K82A 2M10A 1UJDA 4NMQA 3DJ3A 4K76A 2DLSA 2W7RA 3KZEA 1UM1A 5EZ0A 1Q3PA 3KZDA 4K6YA 1R6JA 1FC6A 1VCWA 3CBZA 4Q2PA 1X6DA 2DB5A 2I0LA 1M5ZA 4OEOA 2OMJA 3PDVA 4HOPA 4JOKA 5HFEA 1YBOA 5E6PB 1NF3C 2VWRA 1QAUA 2M0ZA 3GCOA 2IWPA 3GDVA 1WI2A 1MFGA 2PDZA 5HJ1A 4Q2NA 3R69A 4GHNA 2D90A 5HETA 4F8KA 2I04A 3I4WA 3HPMA 2IWNA 3DJAA 5HF4A 3MH4A 2LA8A 4IC6A 2MX6A 3RL8A 4JOJA 4XHVA 2D92A 4NMRA 5HF1A 2HGAA 2YUYA 2KPKA 3GSLA 5HEBA 3ID3A 1WHDA 1V6BA 1B8QA 2KOJA 1OBZA 2KOMA 4Q6HA 2CSSA 2I4SA 2ZPMA 1U37A 3QDOA 1GM1A 2V90A 1V1TA 2L4SA 2KPLA 3TSVA 3GDUA 4H11A 2YUBA 2L4TA 1IHJA 2FCFA 3K1RA 4FGMA 4L8NA 4AMHA 2RCZA 2FE5A 1FCFA 2CSJA 2QT5A 2OPGA 2Z9IA 2DC2A 1QLCA 1OZIA 2QG1A 1KWAA 3SHUA 1OBXA 3JXTA 3I18A
chains in the Genus database with same CATH superfamily
2V1WA 4REYA 4UU5A 4P0CA 1D5GA 2KV8A 1T2MA 1Y8TA 5F67A 2M0VA 3RL7A 4Z33A 2EJYA 2WL7A 2W4FA 2YTWA 1WJLA 3PV2A 2P3WA 1IU0A 2EHRA 3LNXA 4LMMA 2H3LA 2E7KA 3BPUA 1N6FA 2PNTA 3GGEA 5HFFA 4GVDA 2ZPLA 2GEFA 2HE2A 2R3YA 2REYA 1GQ5A 2IWQA 4JJ0A 1N7FA 3SHWA 1MFLA 2EDPA 4Q2OA 2DM8A 1KEFA 4P2AB 1UJUA 3B76A 1MC7A 1U38A 1WH1A 2H2BA 1QAVB 2M0TA 1UF1A 2YT7A 1OBYA 4EDJA 2KJDA 3CBXA 4PQWA 3MH6A 2KA9A 1LCYA 5HEDA 1X5RA 3GJ9A 5E1YA 3GDSA 2MHOA 3CC0A 2EV8A 2OZFA 3MH7A 1U3BA 5GNDA 5F3XA 3E17A 1N99A 3OTPA 2AWXA 2X7ZA 1RGRA 1Q3OA 3PDZA 2OQSA 2M0UA 1P1DA 2Q3GA 2KAWA 3SFJA 2FN5A 4K72A 2F5YA 3HPKA 4G69A 3PS4A 1G9OA 2KQFA 2UZCA 2KRGA 2QKVA 4NMVA 3TSZA 3ID1A 1N7TA 5A2PA 1TP5A 2EEGA 1X8SA 1SOTA 4E3BA 5HFDA 4NXQA 5B6LA 2EGOA 3O5NA 2JOAA 2EAQA 2PKTA 3ID4A 3HVQC 1FC7A 2M3MA 2ENOA 5JXBA 4KFVA 2VZ5A 4JL7A 1IU2A 1UEWA 1X45A 5I7ZA 1VJ6A 2G2LA 1UITA 5G1EA 1X5QA 4NXRA 1SOZA 1BE9A 3NFLA 1UJVA 1GQ4A 3ZRTA 1Y7NA 3QJNA 2KJPA 4NNLA 2AINA 3QO6A 4NMTA 1QAVA 3CH8A 1UEZA 4K75A 2EGNA 3O46A 1VAEA 2JWEA 1N7EA 1UM7A 2BYGA 1RZXA 4YYXA 1ZOKA 2JXOA 4JOHA 1X5NA 3OU0A 5B42A 3QE1A 5DTHA 4OAJA 1PDRA 3SUZA 4R2ZA 3QGLA 3TSWA 3WKMA 1I16A 2KL1A 2KJKA 4Q6SA 3AXAA 1WHAA 2H2CA 2DKRA 3LNYA 3PV4A 2KBSA 2QBWA 2EDVA 4JOGA 1WF8A 2LC6A 2QKTA 3EGHC 2LOBA 4YDPA 4E34A 2G5MB 1UEQA 4NMPA 1WI4A 1UEPA 3DIWA 1BFEA 2R4HA 4FLNA 1Q7XA 2EEHA 4KFWA 4MPAA 3WKLA 4NMSA 1RGWA 3CYYA 3VQFA 4JOEA 3NCVA 2GZVA 1RY4A 3CS0A 5E11A 1UHPA 3NGHA 5HDYA 1K32A 1L6OA 2FNEA 4O06A 2EDZA 1V5LA 3R0HA 5HFBA 2VRFA 2YT8A 4NNMA 4Z8JA 3L4FD 4RI0A 2O2TA 3JXTA 3EGGC 2DJTA 2JILA 3GABA 2Q9VA 4JORA 4WYUA 2LUIA 1W9EA 2HE4A 3SOEA 2VSPA 2I1NA 4Q3HA 1N6DA 2IWOA 5FB8C 4NMOA 1Z87A 2L97A 1TP3A 1VA8A 3NFKA 4JJ3A 2PKUA 2PZDA 2OCSA 3ID2A 5E21A 3PV5A 4E35A 1WIFA 2EEJA 2DAZA 2KYLA 3KDKA 5H3JA 2LC7A 2JINA 4UU6A 3I1EA 3R68A 2OGPA 4JOPA 5HEYA 2EXGA 2DMZA 1WG6A 3FY5A 3TMHA 2OS6A 3KHFA 1I92A 2VSVA 3QIKA 1N6EA 1WFVA 1NTEA 2JREA 4Q2QA 3K50A 2D8IA 3DORA 3KDGA 1Z86A 4N6XA 4WYTA 2AWWA 2JSNA 1W9OA 2CS5A 1TQ3A 4HOPB 5FHTA 5GLJA 5EYZA 3CBYA 4NXPA 1VB7A 2AWUA 5D13A 1V5QA 2RRMA 2VPHA 4JOFA 2OSGA 4OEPA 5HFCA 3GCNA 2JIKA 2I6VA 3VQGA 2QKUA 1WF7A 2Z17A 2KOHA 1FC9A 3RLEA 2K1ZA 4GVCA 5G1DA 2K20A 1ZUBA 1U39A 1UFXA 1TE0A 2DLUA 2EGKA 4K78A 1V62A 2KG2A 3DJ1A 1XZ9A 3STJA 2PA1A 5E22A 1WFGA 1KY9A 2H3MA 1W9QA 3QJMA 2F0AA 2I0IA 1P1EA 2EEIA 3K82A 2M10A 1UJDA 4NMQA 3DJ3A 5IL9A 4K76A 2DLSA 2W7RA 3KZEA 1UM1A 5EZ0A 1Q3PA 3KZDA 4K6YA 1R6JA 1FC6A 1VCWA 3CBZA 4Q2PA 1X6DA 2DB5A 2I0LA 1M5ZA 4OEOA 2OMJA 3PDVA 4HOPA 4JOKA 5HFEA 1YBOA 5E6PB 1NF3C 2VWRA 1QAUA 2M0ZA 3GCOA 2IWPA 3GDVA 1WI2A 1MFGA 2PDZA 5HJ1A 4Q2NA 3R69A 4GHNA 2D90A 5HETA 4F8KA 2I04A 3I4WA 3HPMA 2IWNA 3DJAA 5HF4A 3MH4A 2LA8A 4IC6A 2MX6A 3RL8A 4JOJA 4XHVA 2D92A 4NMRA 5HF1A 2HGAA 2YUYA 2KPKA 3GSLA 5HEBA 3ID3A 1WHDA 1V6BA 1B8QA 2KOJA 1OBZA 1X9ZA 2KOMA 4Q6HA 5ILBA 2CSSA 2I4SA 2ZPMA 1U37A 3QDOA 1GM1A 2V90A 1V1TA 2L4SA 2KPLA 3TSVA 3GDUA 4H11A 2YUBA 2L4TA 1IHJA 2FCFA 3K1RA 4FGMA 4L8NA 4AMHA 2FE5A 1FCFA 2CSJA 2QT5A 2OPGA 2Z9IA 2DC2A 1QLCA 1OZIA 2QG1A 1KWAA 3SHUA 1OBXA 2RCZA 3I18A
chains in the Genus database with same CATH topology
2V1WA 4REYA 4UU5A 4P0CA 1D5GA 2KV8A 1T2MA 1Y8TA 5F67A 2M0VA 3RL7A 4Z33A 2EJYA 2WL7A 2W4FA 2YTWA 1WJLA 3PV2A 2P3WA 1IU0A 2EHRA 3LNXA 4LMMA 2H3LA 2E7KA 3BPUA 1N6FA 2PNTA 3GGEA 5HFFA 4GVDA 2ZPLA 2GEFA 2HE2A 2R3YA 2REYA 1GQ5A 2IWQA 4JJ0A 1N7FA 3SHWA 1MFLA 2EDPA 4Q2OA 2DM8A 1KEFA 4P2AB 1UJUA 3B76A 1MC7A 1U38A 1WH1A 2H2BA 1QAVB 2M0TA 1UF1A 2YT7A 1OBYA 4EDJA 2KJDA 3CBXA 4PQWA 3MH6A 2KA9A 1LCYA 5HEDA 1X5RA 3GJ9A 5E1YA 3GDSA 2MHOA 3CC0A 2EV8A 2OZFA 3MH7A 1U3BA 5GNDA 5F3XA 3E17A 1N99A 3OTPA 2AWXA 2X7ZA 1RGRA 1Q3OA 3PDZA 2OQSA 2M0UA 1P1DA 2Q3GA 2KAWA 3SFJA 2FN5A 4K72A 2F5YA 3HPKA 4G69A 3PS4A 1G9OA 2KQFA 2UZCA 2KRGA 2QKVA 4NMVA 3TSZA 3ID1A 1N7TA 5A2PA 1TP5A 2EEGA 1X8SA 1SOTA 4E3BA 5HFDA 4NXQA 5B6LA 2EGOA 3O5NA 2JOAA 2EAQA 2PKTA 3ID4A 3HVQC 1FC7A 2M3MA 2ENOA 5JXBA 4KFVA 2VZ5A 4JL7A 1IU2A 1UEWA 1X45A 5I7ZA 1VJ6A 2G2LA 1UITA 5G1EA 1X5QA 4NXRA 1SOZA 1BE9A 3NFLA 1UJVA 1GQ4A 3ZRTA 1Y7NA 3QJNA 2KJPA 4NNLA 2AINA 3QO6A 4NMTA 1QAVA 3CH8A 1UEZA 4K75A 2EGNA 3O46A 1VAEA 2JWEA 1N7EA 1UM7A 2BYGA 1RZXA 4YYXA 1ZOKA 2JXOA 4JOHA 1X5NA 3OU0A 5B42A 3QE1A 5DTHA 4OAJA 1PDRA 3SUZA 4R2ZA 3QGLA 3TSWA 3WKMA 1I16A 2KL1A 2KJKA 4Q6SA 3AXAA 1WHAA 2H2CA 2DKRA 3LNYA 3PV4A 2KBSA 2QBWA 2EDVA 4JOGA 1WF8A 2LC6A 2QKTA 3EGHC 2LOBA 4YDPA 4E34A 2G5MB 1UEQA 4NMPA 1WI4A 1UEPA 3DIWA 1BFEA 2R4HA 4FLNA 1Q7XA 2EEHA 4KFWA 4MPAA 3WKLA 4NMSA 1RGWA 3CYYA 3VQFA 4JOEA 3NCVA 2GZVA 1RY4A 3CS0A 5E11A 1UHPA 3NGHA 5HDYA 1K32A 1L6OA 2FNEA 4O06A 2EDZA 1V5LA 3R0HA 5HFBA 2VRFA 2YT8A 4NNMA 4Z8JA 3L4FD 4RI0A 2O2TA 3JXTA 3EGGC 2DJTA 2JILA 3GABA 2Q9VA 4JORA 4WYUA 2LUIA 1W9EA 2HE4A 3SOEA 2VSPA 2I1NA 4Q3HA 1N6DA 2IWOA 5FB8C 4NMOA 1Z87A 2L97A 1TP3A 1VA8A 3NFKA 4JJ3A 2PKUA 2PZDA 2OCSA 3ID2A 5E21A 3PV5A 4E35A 1WIFA 2EEJA 2DAZA 2KYLA 3KDKA 5H3JA 2LC7A 2JINA 4UU6A 3I1EA 3R68A 2OGPA 4JOPA 5HEYA 2EXGA 2DMZA 1WG6A 3FY5A 3TMHA 2OS6A 3KHFA 1I92A 2VSVA 3QIKA 1N6EA 1WFVA 1NTEA 2JREA 4Q2QA 3K50A 2D8IA 3DORA 3KDGA 1Z86A 4N6XA 4WYTA 2AWWA 2JSNA 1W9OA 2CS5A 1TQ3A 4HOPB 5FHTA 5GLJA 5EYZA 3CBYA 4NXPA 1VB7A 2AWUA 5D13A 1V5QA 2RRMA 2VPHA 4JOFA 2OSGA 4OEPA 5HFCA 3GCNA 2JIKA 2I6VA 3VQGA 2QKUA 1WF7A 2Z17A 2KOHA 1FC9A 3RLEA 2K1ZA 4GVCA 5G1DA 2K20A 1ZUBA 1U39A 1UFXA 1TE0A 2DLUA 2EGKA 4K78A 1V62A 2KG2A 3DJ1A 1XZ9A 3STJA 2PA1A 5E22A 1WFGA 1KY9A 2H3MA 1W9QA 3QJMA 2F0AA 2I0IA 1P1EA 2EEIA 3K82A 2M10A 1UJDA 4NMQA 3DJ3A 5IL9A 4K76A 2DLSA 2W7RA 3KZEA 1UM1A 5EZ0A 1Q3PA 3KZDA 4K6YA 1R6JA 1FC6A 1VCWA 3CBZA 4Q2PA 1X6DA 2DB5A 2I0LA 1M5ZA 4OEOA 2OMJA 3PDVA 4HOPA 4JOKA 5HFEA 1YBOA 5E6PB 1NF3C 2VWRA 1QAUA 2M0ZA 3GCOA 2IWPA 3GDVA 1WI2A 1MFGA 2PDZA 5HJ1A 4Q2NA 3R69A 4GHNA 2D90A 5HETA 4F8KA 2I04A 3I4WA 3HPMA 2IWNA 3DJAA 5HF4A 3MH4A 2LA8A 4IC6A 2MX6A 3RL8A 4JOJA 4XHVA 2D92A 4NMRA 5HF1A 2HGAA 2YUYA 2KPKA 3GSLA 5HEBA 3ID3A 1WHDA 1V6BA 1B8QA 2KOJA 1OBZA 1X9ZA 2KOMA 4Q6HA 5ILBA 2CSSA 2I4SA 2ZPMA 1U37A 3QDOA 1GM1A 2V90A 1V1TA 2L4SA 2KPLA 3TSVA 3GDUA 4H11A 2YUBA 2L4TA 1IHJA 2FCFA 3K1RA 4FGMA 4L8NA 4AMHA 2FE5A 1FCFA 2CSJA 2QT5A 2OPGA 2Z9IA 2DC2A 1QLCA 1OZIA 2QG1A 1KWAA 3SHUA 1OBXA 2RCZA 3I18A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V1W A;  4REY A;  4UU5 A;  4P0C A;  1D5G A;  2KV8 A;  1T2M A;  1Y8T A;  5F67 A;  2M0V A;  3RL7 A;  4Z33 A;  2EJY A;  2WL7 A;  2W4F A;  2YTW A;  1WJL A;  3PV2 A;  2P3W A;  1IU0 A;  2EHR A;  3LNX A;  4LMM A;  2H3L A;  2E7K A;  3BPU A;  1N6F A;  2PNT A;  3GGE A;  5HFF A;  4GVD A;  2ZPL A;  2HE2 A;  2R3Y A;  2REY A;  1GQ5 A;  2IWQ A;  1N7F A;  3SHW A;  1MFL A;  2EDP A;  4Q2O A;  2DM8 A;  1KEF A;  4P2A B;  1UJU A;  3B76 A;  1MC7 A;  1U38 A;  1WH1 A;  2H2B A;  1QAV B;  2M0T A;  1UF1 A;  2YT7 A;  1OBY A;  4EDJ A;  2KJD A;  3CBX A;  4PQW A;  3MH6 A;  2KA9 A;  1LCY A;  5HED A;  1X5R A;  3GJ9 A;  5E1Y A;  3GDS A;  2MHO A;  3CC0 A;  2EV8 A;  2OZF A;  3MH7 A;  1U3B A;  5GND A;  5F3X A;  3E17 A;  1N99 A;  3OTP A;  2AWX A;  2X7Z A;  1RGR A;  1Q3O A;  3PDZ A;  2OQS A;  2M0U A;  1P1D A;  2Q3G A;  2KAW A;  3SFJ A;  2FN5 A;  4K72 A;  2F5Y A;  3HPK A;  4G69 A;  3PS4 A;  1G9O A;  2KQF A;  2UZC A;  2KRG A;  2QKV A;  4NMV A;  3TSZ A;  3ID1 A;  1N7T A;  5A2P A;  1TP5 A;  2EEG A;  1X8S A;  1SOT A;  4E3B A;  5HFD A;  4NXQ A;  5B6L A;  2EGO A;  3O5N A;  2JOA A;  2EAQ A;  2PKT A;  3ID4 A;  3HVQ C;  1FC7 A;  2M3M A;  2ENO A;  5JXB A;  4KFV A;  2VZ5 A;  4JL7 A;  1IU2 A;  1UEW A;  1X45 A;  5I7Z A;  1VJ6 A;  2G2L A;  1UIT A;  5G1E A;  1X5Q A;  4NXR A;  1SOZ A;  1BE9 A;  3NFL A;  1UJV A;  1GQ4 A;  3ZRT A;  1Y7N A;  3QJN A;  2KJP A;  4NNL A;  2AIN A;  3QO6 A;  4NMT A;  1QAV A;  3CH8 A;  1UEZ A;  4K75 A;  2EGN A;  3O46 A;  1VAE A;  2JWE A;  1N7E A;  1UM7 A;  2BYG A;  1RZX A;  4YYX A;  1ZOK A;  2JXO A;  4JOH A;  1X5N A;  3OU0 A;  3QE1 A;  5DTH A;  4OAJ A;  1PDR A;  3SUZ A;  4R2Z A;  3QGL A;  3TSW A;  3WKM A;  1I16 A;  2KL1 A;  2KJK A;  4Q6S A;  3AXA A;  1WHA A;  2H2C A;  2DKR A;  3LNY A;  3PV4 A;  2KBS A;  2QBW A;  2EDV A;  4JOG A;  1WF8 A;  2LC6 A;  2QKT A;  3EGH C;  2LOB A;  4YDP A;  4E34 A;  2G5M B;  1UEQ A;  4NMP A;  1WI4 A;  1UEP A;  3DIW A;  1BFE A;  2R4H A;  1Q7X A;  2EEH A;  4KFW A;  4MPA A;  3WKL A;  4NMS A;  1RGW A;  3CYY A;  3VQF A;  4JOE A;  2GZV A;  1RY4 A;  3CS0 A;  5E11 A;  1UHP A;  3NGH A;  5HDY A;  1K32 A;  1L6O A;  2FNE A;  4O06 A;  2EDZ A;  1V5L A;  3R0H A;  5HFB A;  2VRF A;  2YT8 A;  4NNM A;  4Z8J A;  3L4F D;  4RI0 A;  2O2T A;  3EGG C;  2DJT A;  2JIL A;  2Q9V A;  4JOR A;  4WYU A;  2LUI A;  1W9E A;  2HE4 A;  3SOE A;  2VSP A;  2I1N A;  4Q3H A;  1N6D A;  2IWO A;  5FB8 C;  4NMO A;  1Z87 A;  2L97 A;  1TP3 A;  1VA8 A;  3NFK A;  2PKU A;  2PZD A;  2OCS A;  3ID2 A;  5E21 A;  3PV5 A;  4E35 A;  1WIF A;  2EEJ A;  2DAZ A;  2KYL A;  5H3J A;  2LC7 A;  2JIN A;  4UU6 A;  3I1E A;  3R68 A;  2OGP A;  4JOP A;  5HEY A;  2EXG A;  2DMZ A;  1WG6 A;  3FY5 A;  3TMH A;  2OS6 A;  3KHF A;  1I92 A;  2VSV A;  3QIK A;  1N6E A;  1WFV A;  1NTE A;  2JRE A;  4Q2Q A;  3K50 A;  2D8I A;  3DOR A;  1Z86 A;  4N6X A;  4WYT A;  2AWW A;  1W9O A;  2CS5 A;  1TQ3 A;  4HOP B;  5FHT A;  5GLJ A;  5EYZ A;  3CBY A;  4NXP A;  1VB7 A;  2AWU A;  5D13 A;  1V5Q A;  2RRM A;  2VPH A;  4JOF A;  2OSG A;  4OEP A;  5HFC A;  3GCN A;  2JIK A;  2I6V A;  3VQG A;  2QKU A;  1WF7 A;  2Z17 A;  2KOH A;  1FC9 A;  3RLE A;  2K1Z A;  4GVC A;  5G1D A;  2K20 A;  1ZUB A;  1U39 A;  1UFX A;  1TE0 A;  2DLU A;  2EGK A;  4K78 A;  1V62 A;  2KG2 A;  3DJ1 A;  1XZ9 A;  3STJ A;  2PA1 A;  5E22 A;  1WFG A;  1KY9 A;  2H3M A;  1W9Q A;  3QJM A;  2F0A A;  2I0I A;  1P1E A;  2EEI A;  3K82 A;  2M10 A;  1UJD A;  4NMQ A;  3DJ3 A;  4K76 A;  2DLS A;  2W7R A;  3KZE A;  1UM1 A;  5EZ0 A;  1Q3P A;  3KZD A;  4K6Y A;  1R6J A;  1FC6 A;  1VCW A;  3CBZ A;  4Q2P A;  1X6D A;  2DB5 A;  2I0L A;  1M5Z A;  4OEO A;  2OMJ A;  3PDV A;  4HOP A;  4JOK A;  5HFE A;  1YBO A;  5E6P B;  1NF3 C;  2VWR A;  1QAU A;  2M0Z A;  3GCO A;  2IWP A;  3GDV A;  1WI2 A;  1MFG A;  2PDZ A;  5HJ1 A;  4Q2N A;  3R69 A;  4GHN A;  2D90 A;  5HET A;  4F8K A;  2I04 A;  3I4W A;  3HPM A;  2IWN A;  3DJA A;  5HF4 A;  3MH4 A;  2LA8 A;  4IC6 A;  2MX6 A;  3RL8 A;  4JOJ A;  4XHV A;  2D92 A;  4NMR A;  5HF1 A;  2HGA A;  2YUY A;  2KPK A;  3GSL A;  5HEB A;  3ID3 A;  1WHD A;  1V6B A;  1B8Q A;  2KOJ A;  1OBZ A;  2KOM A;  4Q6H A;  2CSS A;  2I4S A;  2ZPM A;  1U37 A;  3QDO A;  1GM1 A;  2V90 A;  1V1T A;  2L4S A;  2KPL A;  3TSV A;  3GDU A;  4H11 A;  2YUB A;  2L4T A;  1IHJ A;  2FCF A;  3K1R A;  4FGM A;  4L8N A;  4AMH A;  2RCZ A;  2FE5 A;  1FCF A;  2CSJ A;  2QT5 A;  2OPG A;  2Z9I A;  2DC2 A;  1QLC A;  1OZI A;  2QG1 A;  1KWA A;  3SHU A;  1OBX A;  3JXT A;  3I18 A; 
#chains in the Genus database with same CATH topology
 2V1W A;  4REY A;  4UU5 A;  4P0C A;  1D5G A;  2KV8 A;  1T2M A;  1Y8T A;  5F67 A;  2M0V A;  3RL7 A;  4Z33 A;  2EJY A;  2WL7 A;  2W4F A;  2YTW A;  1WJL A;  3PV2 A;  2P3W A;  1IU0 A;  2EHR A;  3LNX A;  4LMM A;  2H3L A;  2E7K A;  3BPU A;  1N6F A;  2PNT A;  3GGE A;  5HFF A;  4GVD A;  2ZPL A;  2GEF A;  2HE2 A;  2R3Y A;  2REY A;  1GQ5 A;  2IWQ A;  4JJ0 A;  1N7F A;  3SHW A;  1MFL A;  2EDP A;  4Q2O A;  2DM8 A;  1KEF A;  4P2A B;  1UJU A;  3B76 A;  1MC7 A;  1U38 A;  1WH1 A;  2H2B A;  1QAV B;  2M0T A;  1UF1 A;  2YT7 A;  1OBY A;  4EDJ A;  2KJD A;  3CBX A;  4PQW A;  3MH6 A;  2KA9 A;  1LCY A;  5HED A;  1X5R A;  3GJ9 A;  5E1Y A;  3GDS A;  2MHO A;  3CC0 A;  2EV8 A;  2OZF A;  3MH7 A;  1U3B A;  5GND A;  5F3X A;  3E17 A;  1N99 A;  3OTP A;  2AWX A;  2X7Z A;  1RGR A;  1Q3O A;  3PDZ A;  2OQS A;  2M0U A;  1P1D A;  2Q3G A;  2KAW A;  3SFJ A;  2FN5 A;  4K72 A;  2F5Y A;  3HPK A;  4G69 A;  3PS4 A;  1G9O A;  2KQF A;  2UZC A;  2KRG A;  2QKV A;  4NMV A;  3TSZ A;  3ID1 A;  1N7T A;  5A2P A;  1TP5 A;  2EEG A;  1X8S A;  1SOT A;  4E3B A;  5HFD A;  4NXQ A;  5B6L A;  2EGO A;  3O5N A;  2JOA A;  2EAQ A;  2PKT A;  3ID4 A;  3HVQ C;  1FC7 A;  2M3M A;  2ENO A;  5JXB A;  4KFV A;  2VZ5 A;  4JL7 A;  1IU2 A;  1UEW A;  1X45 A;  5I7Z A;  1VJ6 A;  2G2L A;  1UIT A;  5G1E A;  1X5Q A;  4NXR A;  1SOZ A;  1BE9 A;  3NFL A;  1UJV A;  1GQ4 A;  3ZRT A;  1Y7N A;  3QJN A;  2KJP A;  4NNL A;  2AIN A;  3QO6 A;  4NMT A;  1QAV A;  3CH8 A;  1UEZ A;  4K75 A;  2EGN A;  3O46 A;  1VAE A;  2JWE A;  1N7E A;  1UM7 A;  2BYG A;  1RZX A;  4YYX A;  1ZOK A;  2JXO A;  4JOH A;  1X5N A;  3OU0 A;  5B42 A;  3QE1 A;  5DTH A;  4OAJ A;  1PDR A;  3SUZ A;  4R2Z A;  3QGL A;  3TSW A;  3WKM A;  1I16 A;  2KL1 A;  2KJK A;  4Q6S A;  3AXA A;  1WHA A;  2H2C A;  2DKR A;  3LNY A;  3PV4 A;  2KBS A;  2QBW A;  2EDV A;  4JOG A;  1WF8 A;  2LC6 A;  2QKT A;  3EGH C;  2LOB A;  4YDP A;  4E34 A;  2G5M B;  1UEQ A;  4NMP A;  1WI4 A;  1UEP A;  3DIW A;  1BFE A;  2R4H A;  4FLN A;  1Q7X A;  2EEH A;  4KFW A;  4MPA A;  3WKL A;  4NMS A;  1RGW A;  3CYY A;  3VQF A;  4JOE A;  3NCV A;  2GZV A;  1RY4 A;  3CS0 A;  5E11 A;  1UHP A;  3NGH A;  5HDY A;  1K32 A;  1L6O A;  2FNE A;  4O06 A;  2EDZ A;  1V5L A;  3R0H A;  5HFB A;  2VRF A;  2YT8 A;  4NNM A;  4Z8J A;  3L4F D;  4RI0 A;  2O2T A;  3JXT A;  3EGG C;  2DJT A;  2JIL A;  3GAB A;  2Q9V A;  4JOR A;  4WYU A;  2LUI A;  1W9E A;  2HE4 A;  3SOE A;  2VSP A;  2I1N A;  4Q3H A;  1N6D A;  2IWO A;  5FB8 C;  4NMO A;  1Z87 A;  2L97 A;  1TP3 A;  1VA8 A;  3NFK A;  4JJ3 A;  2PKU A;  2PZD A;  2OCS A;  3ID2 A;  5E21 A;  3PV5 A;  4E35 A;  1WIF A;  2EEJ A;  2DAZ A;  2KYL A;  3KDK A;  5H3J A;  2LC7 A;  2JIN A;  4UU6 A;  3I1E A;  3R68 A;  2OGP A;  4JOP A;  5HEY A;  2EXG A;  2DMZ A;  1WG6 A;  3FY5 A;  3TMH A;  2OS6 A;  3KHF A;  1I92 A;  2VSV A;  3QIK A;  1N6E A;  1WFV A;  1NTE A;  2JRE A;  4Q2Q A;  3K50 A;  2D8I A;  3DOR A;  3KDG A;  1Z86 A;  4N6X A;  4WYT A;  2AWW A;  2JSN A;  1W9O A;  2CS5 A;  1TQ3 A;  4HOP B;  5FHT A;  5GLJ A;  5EYZ A;  3CBY A;  4NXP A;  1VB7 A;  2AWU A;  5D13 A;  1V5Q A;  2RRM A;  2VPH A;  4JOF A;  2OSG A;  4OEP A;  5HFC A;  3GCN A;  2JIK A;  2I6V A;  3VQG A;  2QKU A;  1WF7 A;  2Z17 A;  2KOH A;  1FC9 A;  3RLE A;  2K1Z A;  4GVC A;  5G1D A;  2K20 A;  1ZUB A;  1U39 A;  1UFX A;  1TE0 A;  2DLU A;  2EGK A;  4K78 A;  1V62 A;  2KG2 A;  3DJ1 A;  1XZ9 A;  3STJ A;  2PA1 A;  5E22 A;  1WFG A;  1KY9 A;  2H3M A;  1W9Q A;  3QJM A;  2F0A A;  2I0I A;  1P1E A;  2EEI A;  3K82 A;  2M10 A;  1UJD A;  4NMQ A;  3DJ3 A;  5IL9 A;  4K76 A;  2DLS A;  2W7R A;  3KZE A;  1UM1 A;  5EZ0 A;  1Q3P A;  3KZD A;  4K6Y A;  1R6J A;  1FC6 A;  1VCW A;  3CBZ A;  4Q2P A;  1X6D A;  2DB5 A;  2I0L A;  1M5Z A;  4OEO A;  2OMJ A;  3PDV A;  4HOP A;  4JOK A;  5HFE A;  1YBO A;  5E6P B;  1NF3 C;  2VWR A;  1QAU A;  2M0Z A;  3GCO A;  2IWP A;  3GDV A;  1WI2 A;  1MFG A;  2PDZ A;  5HJ1 A;  4Q2N A;  3R69 A;  4GHN A;  2D90 A;  5HET A;  4F8K A;  2I04 A;  3I4W A;  3HPM A;  2IWN A;  3DJA A;  5HF4 A;  3MH4 A;  2LA8 A;  4IC6 A;  2MX6 A;  3RL8 A;  4JOJ A;  4XHV A;  2D92 A;  4NMR A;  5HF1 A;  2HGA A;  2YUY A;  2KPK A;  3GSL A;  5HEB A;  3ID3 A;  1WHD A;  1V6B A;  1B8Q A;  2KOJ A;  1OBZ A;  1X9Z A;  2KOM A;  4Q6H A;  5ILB A;  2CSS A;  2I4S A;  2ZPM A;  1U37 A;  3QDO A;  1GM1 A;  2V90 A;  1V1T A;  2L4S A;  2KPL A;  3TSV A;  3GDU A;  4H11 A;  2YUB A;  2L4T A;  1IHJ A;  2FCF A;  3K1R A;  4FGM A;  4L8N A;  4AMH A;  2FE5 A;  1FCF A;  2CSJ A;  2QT5 A;  2OPG A;  2Z9I A;  2DC2 A;  1QLC A;  1OZI A;  2QG1 A;  1KWA A;  3SHU A;  1OBX A;  2RCZ A;  3I18 A; 
#chains in the Genus database with same CATH homology
 2V1W A;  4REY A;  4UU5 A;  4P0C A;  1D5G A;  2KV8 A;  1T2M A;  1Y8T A;  5F67 A;  2M0V A;  3RL7 A;  4Z33 A;  2EJY A;  2WL7 A;  2W4F A;  2YTW A;  1WJL A;  3PV2 A;  2P3W A;  1IU0 A;  2EHR A;  3LNX A;  4LMM A;  2H3L A;  2E7K A;  3BPU A;  1N6F A;  2PNT A;  3GGE A;  5HFF A;  4GVD A;  2ZPL A;  2GEF A;  2HE2 A;  2R3Y A;  2REY A;  1GQ5 A;  2IWQ A;  4JJ0 A;  1N7F A;  3SHW A;  1MFL A;  2EDP A;  4Q2O A;  2DM8 A;  1KEF A;  4P2A B;  1UJU A;  3B76 A;  1MC7 A;  1U38 A;  1WH1 A;  2H2B A;  1QAV B;  2M0T A;  1UF1 A;  2YT7 A;  1OBY A;  4EDJ A;  2KJD A;  3CBX A;  4PQW A;  3MH6 A;  2KA9 A;  1LCY A;  5HED A;  1X5R A;  3GJ9 A;  5E1Y A;  3GDS A;  2MHO A;  3CC0 A;  2EV8 A;  2OZF A;  3MH7 A;  1U3B A;  5GND A;  5F3X A;  3E17 A;  1N99 A;  3OTP A;  2AWX A;  2X7Z A;  1RGR A;  1Q3O A;  3PDZ A;  2OQS A;  2M0U A;  1P1D A;  2Q3G A;  2KAW A;  3SFJ A;  2FN5 A;  4K72 A;  2F5Y A;  3HPK A;  4G69 A;  3PS4 A;  1G9O A;  2KQF A;  2UZC A;  2KRG A;  2QKV A;  4NMV A;  3TSZ A;  3ID1 A;  1N7T A;  5A2P A;  1TP5 A;  2EEG A;  1X8S A;  1SOT A;  4E3B A;  5HFD A;  4NXQ A;  5B6L A;  2EGO A;  3O5N A;  2JOA A;  2EAQ A;  2PKT A;  3ID4 A;  3HVQ C;  1FC7 A;  2M3M A;  2ENO A;  5JXB A;  4KFV A;  2VZ5 A;  4JL7 A;  1IU2 A;  1UEW A;  1X45 A;  5I7Z A;  1VJ6 A;  2G2L A;  1UIT A;  5G1E A;  1X5Q A;  4NXR A;  1SOZ A;  1BE9 A;  3NFL A;  1UJV A;  1GQ4 A;  3ZRT A;  1Y7N A;  3QJN A;  2KJP A;  4NNL A;  2AIN A;  3QO6 A;  4NMT A;  1QAV A;  3CH8 A;  1UEZ A;  4K75 A;  2EGN A;  3O46 A;  1VAE A;  2JWE A;  1N7E A;  1UM7 A;  2BYG A;  1RZX A;  4YYX A;  1ZOK A;  2JXO A;  4JOH A;  1X5N A;  3OU0 A;  5B42 A;  3QE1 A;  5DTH A;  4OAJ A;  1PDR A;  3SUZ A;  4R2Z A;  3QGL A;  3TSW A;  3WKM A;  1I16 A;  2KL1 A;  2KJK A;  4Q6S A;  3AXA A;  1WHA A;  2H2C A;  2DKR A;  3LNY A;  3PV4 A;  2KBS A;  2QBW A;  2EDV A;  4JOG A;  1WF8 A;  2LC6 A;  2QKT A;  3EGH C;  2LOB A;  4YDP A;  4E34 A;  2G5M B;  1UEQ A;  4NMP A;  1WI4 A;  1UEP A;  3DIW A;  1BFE A;  2R4H A;  4FLN A;  1Q7X A;  2EEH A;  4KFW A;  4MPA A;  3WKL A;  4NMS A;  1RGW A;  3CYY A;  3VQF A;  4JOE A;  3NCV A;  2GZV A;  1RY4 A;  3CS0 A;  5E11 A;  1UHP A;  3NGH A;  5HDY A;  1K32 A;  1L6O A;  2FNE A;  4O06 A;  2EDZ A;  1V5L A;  3R0H A;  5HFB A;  2VRF A;  2YT8 A;  4NNM A;  4Z8J A;  3L4F D;  4RI0 A;  2O2T A;  3JXT A;  3EGG C;  2DJT A;  2JIL A;  3GAB A;  2Q9V A;  4JOR A;  4WYU A;  2LUI A;  1W9E A;  2HE4 A;  3SOE A;  2VSP A;  2I1N A;  4Q3H A;  1N6D A;  2IWO A;  5FB8 C;  4NMO A;  1Z87 A;  2L97 A;  1TP3 A;  1VA8 A;  3NFK A;  4JJ3 A;  2PKU A;  2PZD A;  2OCS A;  3ID2 A;  5E21 A;  3PV5 A;  4E35 A;  1WIF A;  2EEJ A;  2DAZ A;  2KYL A;  3KDK A;  5H3J A;  2LC7 A;  2JIN A;  4UU6 A;  3I1E A;  3R68 A;  2OGP A;  4JOP A;  5HEY A;  2EXG A;  2DMZ A;  1WG6 A;  3FY5 A;  3TMH A;  2OS6 A;  3KHF A;  1I92 A;  2VSV A;  3QIK A;  1N6E A;  1WFV A;  1NTE A;  2JRE A;  4Q2Q A;  3K50 A;  2D8I A;  3DOR A;  3KDG A;  1Z86 A;  4N6X A;  4WYT A;  2AWW A;  2JSN A;  1W9O A;  2CS5 A;  1TQ3 A;  4HOP B;  5FHT A;  5GLJ A;  5EYZ A;  3CBY A;  4NXP A;  1VB7 A;  2AWU A;  5D13 A;  1V5Q A;  2RRM A;  2VPH A;  4JOF A;  2OSG A;  4OEP A;  5HFC A;  3GCN A;  2JIK A;  2I6V A;  3VQG A;  2QKU A;  1WF7 A;  2Z17 A;  2KOH A;  1FC9 A;  3RLE A;  2K1Z A;  4GVC A;  5G1D A;  2K20 A;  1ZUB A;  1U39 A;  1UFX A;  1TE0 A;  2DLU A;  2EGK A;  4K78 A;  1V62 A;  2KG2 A;  3DJ1 A;  1XZ9 A;  3STJ A;  2PA1 A;  5E22 A;  1WFG A;  1KY9 A;  2H3M A;  1W9Q A;  3QJM A;  2F0A A;  2I0I A;  1P1E A;  2EEI A;  3K82 A;  2M10 A;  1UJD A;  4NMQ A;  3DJ3 A;  5IL9 A;  4K76 A;  2DLS A;  2W7R A;  3KZE A;  1UM1 A;  5EZ0 A;  1Q3P A;  3KZD A;  4K6Y A;  1R6J A;  1FC6 A;  1VCW A;  3CBZ A;  4Q2P A;  1X6D A;  2DB5 A;  2I0L A;  1M5Z A;  4OEO A;  2OMJ A;  3PDV A;  4HOP A;  4JOK A;  5HFE A;  1YBO A;  5E6P B;  1NF3 C;  2VWR A;  1QAU A;  2M0Z A;  3GCO A;  2IWP A;  3GDV A;  1WI2 A;  1MFG A;  2PDZ A;  5HJ1 A;  4Q2N A;  3R69 A;  4GHN A;  2D90 A;  5HET A;  4F8K A;  2I04 A;  3I4W A;  3HPM A;  2IWN A;  3DJA A;  5HF4 A;  3MH4 A;  2LA8 A;  4IC6 A;  2MX6 A;  3RL8 A;  4JOJ A;  4XHV A;  2D92 A;  4NMR A;  5HF1 A;  2HGA A;  2YUY A;  2KPK A;  3GSL A;  5HEB A;  3ID3 A;  1WHD A;  1V6B A;  1B8Q A;  2KOJ A;  1OBZ A;  1X9Z A;  2KOM A;  4Q6H A;  5ILB A;  2CSS A;  2I4S A;  2ZPM A;  1U37 A;  3QDO A;  1GM1 A;  2V90 A;  1V1T A;  2L4S A;  2KPL A;  3TSV A;  3GDU A;  4H11 A;  2YUB A;  2L4T A;  1IHJ A;  2FCF A;  3K1R A;  4FGM A;  4L8N A;  4AMH A;  2FE5 A;  1FCF A;  2CSJ A;  2QT5 A;  2OPG A;  2Z9I A;  2DC2 A;  1QLC A;  1OZI A;  2QG1 A;  1KWA A;  3SHU A;  1OBX A;  2RCZ A;  3I18 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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