3O5NA

Tetrahydroquinoline carboxylates are potent inhibitors of the shank pdz domain, a putative target in autism disorders
Total Genus 16
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
106
structure length
100
Chain Sequence
SDYVIDDKVAILQKRDHEGFGFVLRGIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVGLIRQGGNRLVMKVVSVTRKP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the shank3 PDZ domain.
pubmed doi rcsb
molecule tags Protein binding
source organism Mus musculus
molecule keywords SH3 and multiple ankyrin repeat domains protein 3
total genus 16
structure length 100
sequence length 106
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature
pdb deposition date 2010-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF17820 PDZ_6 PDZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.42.10 Mainly Beta Roll Pdz3 Domain Pdz3 Domain 3o5nA00
2EGOA 3LNYA 4Q2OA 2OPGA 5I7ZA 3HPMA 2LC7A 3BPUA 5E6PB 3CBZA 2K1ZA 3FY5A 4NMVA 3RLEA 2FCFA 3OU0A 2DLSA 5HEBA 1V5LA 3NFLA 3RL7A 1MFLA 2Q9VA 3I1EA 4JOEA 1Z86A 2K20A 1UM7A 4K76A 4E3BA 1NTEA 1RGRA 1UEPA 2BYGA 3R0HA 4PQWA 2FE5A 2DB5A 2AWWA 3GCOA 2EJYA 1KEFA 1R6JA 4Q3HA 1V62A 4REYA 1N6DA 1G9OA 3GSLA 2EEJA 2FNEA 1TE0A 5E11A 2OMJA 2OZFA 5G1EA 1N6FA 2G2LA 2QKVA 3QO6A 5HF1A 1MC7A 2Z17A 1WF7A 1X5QA 2JILA 2I0IA 2KOMA 4G69A 2G5MB 1WI4A 2QKTA 3RL8A 4K78A 2E7KA 3MH6A 1VB7A 2EXGA 2KAWA 3CBXA 3K1RA 2DLUA 2KJDA 2W4FA 4NMRA 1GM1A 4N6XA 2L97A 5EYZA 2M10A 4EDJA 2M3MA 1RZXA 1Z87A 3QE1A 1QAVA 3NGHA 5E21A 2V1WA 3MH7A 3QDOA 3TSZA 2IWOA 1W9EA 2YT8A 1TP5A 3JXTA 2ZPMA 3I4WA 3QGLA 1X45A 1UJVA 1V1TA 1UJUA 2EGNA 1WIFA 3SHUA 1FC7A 2KBSA 2R4HA 3WKLA 1U38A 3KZDA 4NMQA 1U37A 3QJMA 2JWEA 4OAJA 2OCSA 4OEOA 1N7FA 1UEZA 1UM1A 2CSSA 2UZCA 2L4SA 2QBWA 2DAZA 3ID4A 4XHVA 2JIKA 1WFGA 2PNTA 2OGPA 3O5NA 3QJNA 2VSVA 2KOJA 1WJLA 4K6YA 4NXPA 1UITA 2Z9IA 1BE9A 4JOGA 5HFCA 5HEDA 5HFFA 3PV4A 1QAVB 4E35A 3SOEA 3K82A 3GDSA 5F67A 2CS5A 3PV5A 2QT5A 2X7ZA 2QKUA 3CBYA 4K75A 1UEQA 4NNMA 2KRGA 4F8KA 3HVQC 4Q2PA 2V90A 2YTWA 2H3MA 2IWPA 2VPHA 1LCYA 5HF4A 1TP3A 2EHRA 1UEWA 1UJDA 2W7RA 3GCNA 3CS0A 1X5NA 4FGMA 1VCWA 5FB8C 4HOPA 2EEHA 2EAQA 5HFDA 3WKMA 4NXQA 3SUZA 2OQSA 4Q6HA 5E22A 4Z8JA 2VRFA 1KWAA 2DC2A 1UF1A 3DIWA 2LC6A 2D92A 3SHWA 1Q7XA 3HPKA 4LMMA 1IU0A 4Q2QA 4JOPA 3DORA 1L6OA 2LA8A 3KHFA 4OEPA 2GZVA 3DJ1A 1SOZA 1M5ZA 5A2PA 2HE4A 2PDZA 5GLJA 5HFEA 3R69A 4HOPB 2DM8A 1VJ6A 2JOAA 1FC9A 2JINA 2KV8A 3LNXA 1X8SA 4NMOA 1Q3OA 2D8IA 3TSVA 5HDYA 2OSGA 1X6DA 3ID3A 2EDPA 5H3JA 4L8NA 2EGKA 1V5QA 1OBZA 5B6LA 3PDVA 4JORA 1MFGA 4KFVA 1U39A 3EGHC 2I4SA 4Q2NA 2KL1A 4GVCA 2ZPLA 2M0TA 1Y7NA 2P3WA 1W9OA 5G1DA 1VAEA 4NXRA 1BFEA 2H2BA 1N7EA 2JREA 3GJ9A 4UU5A 3QIKA 2I1NA 4NMSA 1P1DA 2IWNA 2AWXA 2I0LA 1XZ9A 1GQ5A 2HGAA 1RY4A 1T2MA 1NF3C 2H3LA 2KG2A 2KPLA 2M0ZA 4WYTA 4E34A 1Q3PA 2EEGA 2MX6A 2KJPA 2O2TA 1VA8A 2REYA 2EDVA 2KYLA 3SFJA 4GVDA 1U3BA 1P1EA 2F5YA 1WF8A 1Y8TA 3MH4A 2VZ5A 4YDPA 2M0VA 2RRMA 2KA9A 1I92A 3ZRTA 2KPKA 2L4TA 4Q6SA 3B76A 5GNDA 2FN5A 2KQFA 3GDUA 1B8QA 3ID1A 3EGGC 1IU2A 2ENOA 2Q3GA 3GGEA 4MPAA 5F3XA 5HETA 4NNLA 2QG1A 3ID2A 4O06A 2YUBA 4IC6A 3PDZA 3E17A 1ZUBA 1WG6A 2CSJA 1WI2A 2PKUA 3R68A 4JOFA 1WH1A 4GHNA 2WL7A 3CH8A 2MHOA 3PS4A 2VWRA 2LOBA 3O46A 1UFXA 1N7TA 2HE2A 3GDVA 1KY9A 4JL7A 1W9QA 1V6BA 2KJKA 3VQFA 2DMZA 1I16A 3K50A 2DJTA 4AMHA 2PA1A 3AXAA 5D13A 1OBXA 2YT7A 3NFKA 1QAUA 2R3YA 2EEIA 5HEYA 1WFVA 2D90A 4P0CA 3TMHA 4JOHA 4NMTA 1YBOA 5FHTA 1OZIA 2KOHA 1X5RA 1N6EA 2PZDA 5EZ0A 5JXBA 4RI0A 5DTHA 3KZEA 3I18A 1IHJA 1PDRA 2LUIA 2F0AA 2I04A 4JOJA 3VQGA 2AWUA 4Z33A 2YUYA 2IWQA 2H2CA 1K32A 4WYUA 2PKTA 2EDZA 2OS6A 2DKRA 4K72A 4R2ZA 4UU6A 1RGWA 1WHAA 2RCZA 3STJA 4JOKA 1QLCA 1WHDA 1OBYA 2AINA 1SOTA 3CC0A 3TSWA 2VSPA 3OTPA 2EV8A 3L4FD 4YYXA 1D5GA 5E1YA 1TQ3A 2M0UA 4P2AB 1N99A 2I6VA 1FCFA 5HFBA 4KFWA 2JXOA 3CYYA 4NMPA 4H11A 1ZOKA 3PV2A 1FC6A 3DJ3A 3DJAA 1GQ4A 1UHPA 5HJ1A
chains in the Genus database with same CATH superfamily
2EGOA 3LNYA 4Q2OA 2OPGA 5I7ZA 3HPMA 2JSNA 2LC7A 3BPUA 5E6PB 3CBZA 2K1ZA 3FY5A 4NMVA 3RLEA 2FCFA 3OU0A 2DLSA 5HEBA 1V5LA 3NFLA 3RL7A 1MFLA 2Q9VA 3I1EA 4JOEA 1Z86A 2K20A 1UM7A 4K76A 4E3BA 1NTEA 1RGRA 1UEPA 2BYGA 3R0HA 4PQWA 2FE5A 2DB5A 2AWWA 3GCOA 2EJYA 1KEFA 1R6JA 4Q3HA 1V62A 4REYA 1N6DA 1G9OA 3GSLA 2EEJA 2FNEA 1TE0A 5E11A 2OMJA 2OZFA 5G1EA 1N6FA 2G2LA 2QKVA 5IL9A 3QO6A 5HF1A 1MC7A 2Z17A 1WF7A 4JJ3A 1X5QA 2JILA 2I0IA 2KOMA 4G69A 2G5MB 1WI4A 2QKTA 3RL8A 4K78A 2E7KA 3MH6A 1VB7A 2EXGA 2KAWA 3CBXA 3K1RA 2DLUA 2KJDA 2W4FA 4NMRA 1GM1A 4N6XA 2L97A 5EYZA 2M10A 4EDJA 2M3MA 1RZXA 1Z87A 3QE1A 1QAVA 3NGHA 5E21A 2V1WA 3MH7A 3QDOA 3TSZA 2IWOA 1W9EA 2YT8A 1TP5A 3JXTA 2ZPMA 3I4WA 3QGLA 1X45A 1UJVA 1V1TA 1UJUA 2EGNA 1WIFA 3SHUA 1FC7A 2KBSA 2R4HA 3WKLA 1U38A 3KZDA 4NMQA 1U37A 3QJMA 2JWEA 4OAJA 2OCSA 4OEOA 1N7FA 1UEZA 1UM1A 2CSSA 2UZCA 2L4SA 2QBWA 2DAZA 3ID4A 4XHVA 2JIKA 1WFGA 2PNTA 2OGPA 3O5NA 4FLNA 3QJNA 2VSVA 2KOJA 1WJLA 4K6YA 4NXPA 1UITA 2Z9IA 1BE9A 4JOGA 5HFCA 5HEDA 5HFFA 3PV4A 1QAVB 4E35A 3SOEA 3K82A 3GDSA 5F67A 2CS5A 3PV5A 2QT5A 2X7ZA 2QKUA 3CBYA 4K75A 5B42A 1UEQA 4NNMA 2KRGA 4F8KA 3HVQC 4Q2PA 2V90A 2YTWA 2H3MA 2IWPA 2VPHA 1LCYA 5HF4A 1TP3A 2EHRA 1UEWA 1UJDA 2W7RA 3GCNA 3CS0A 1X5NA 4FGMA 1VCWA 5FB8C 4HOPA 5ILBA 2EEHA 2EAQA 3NCVA 5HFDA 3WKMA 4NXQA 3SUZA 1X9ZA 2OQSA 4Q6HA 5E22A 4Z8JA 2VRFA 1KWAA 2DC2A 1UF1A 3DIWA 2LC6A 2D92A 3SHWA 1Q7XA 3HPKA 4LMMA 1IU0A 4Q2QA 4JOPA 3DORA 1L6OA 2LA8A 3KHFA 4OEPA 2GZVA 3DJ1A 1SOZA 1M5ZA 5A2PA 2HE4A 2PDZA 5GLJA 5HFEA 3R69A 4HOPB 2DM8A 1VJ6A 2JOAA 4JJ0A 1FC9A 2JINA 2KV8A 3LNXA 1X8SA 4NMOA 1Q3OA 2D8IA 3TSVA 5HDYA 2OSGA 1X6DA 3ID3A 2EDPA 5H3JA 4L8NA 2EGKA 1V5QA 1OBZA 5B6LA 3PDVA 4JORA 1MFGA 4KFVA 1U39A 3EGHC 2I4SA 4Q2NA 2KL1A 4GVCA 2ZPLA 2M0TA 1Y7NA 2P3WA 1W9OA 5G1DA 1VAEA 4NXRA 1BFEA 2H2BA 1N7EA 2JREA 3GJ9A 4UU5A 3QIKA 2I1NA 4NMSA 1P1DA 2IWNA 2AWXA 2I0LA 1XZ9A 1GQ5A 2HGAA 1RY4A 1T2MA 1NF3C 2H3LA 2KG2A 2KPLA 2M0ZA 4WYTA 4E34A 1Q3PA 2EEGA 2MX6A 2KJPA 2O2TA 1VA8A 2REYA 2EDVA 2KYLA 3SFJA 4GVDA 1U3BA 1P1EA 2F5YA 1WF8A 1Y8TA 3MH4A 2VZ5A 4YDPA 2M0VA 2RRMA 2KA9A 1I92A 3ZRTA 2KPKA 2L4TA 4Q6SA 3B76A 5GNDA 2FN5A 2KQFA 3GDUA 1B8QA 3ID1A 3EGGC 1IU2A 2ENOA 2Q3GA 3GGEA 4MPAA 5F3XA 5HETA 4NNLA 2QG1A 3ID2A 4O06A 2YUBA 4IC6A 3PDZA 3E17A 3KDKA 1ZUBA 1WG6A 2CSJA 1WI2A 2PKUA 3R68A 4JOFA 1WH1A 4GHNA 2WL7A 3CH8A 2MHOA 3PS4A 2VWRA 2LOBA 3O46A 1UFXA 1N7TA 2HE2A 3GDVA 1KY9A 3GABA 4JL7A 1W9QA 1V6BA 2KJKA 3VQFA 2DMZA 1I16A 3K50A 3KDGA 2DJTA 4AMHA 2PA1A 3AXAA 5D13A 1OBXA 2YT7A 3NFKA 1QAUA 2R3YA 2EEIA 5HEYA 1WFVA 2D90A 4P0CA 3TMHA 4JOHA 4NMTA 1YBOA 5FHTA 1OZIA 2KOHA 1X5RA 1N6EA 2PZDA 5EZ0A 5JXBA 4RI0A 5DTHA 3KZEA 3I18A 1IHJA 1PDRA 2LUIA 2F0AA 2I04A 4JOJA 3VQGA 2AWUA 4Z33A 2YUYA 2IWQA 2H2CA 1K32A 4WYUA 2PKTA 2EDZA 2OS6A 2DKRA 4K72A 4R2ZA 4UU6A 1RGWA 1WHAA 2RCZA 3STJA 4JOKA 1QLCA 1WHDA 1OBYA 2AINA 1SOTA 3CC0A 3TSWA 2VSPA 3OTPA 2EV8A 3L4FD 4YYXA 1D5GA 5E1YA 1TQ3A 2M0UA 4P2AB 1N99A 2I6VA 1FCFA 5HFBA 4KFWA 2JXOA 3CYYA 4NMPA 4H11A 1ZOKA 3PV2A 2GEFA 1FC6A 3DJ3A 3DJAA 1GQ4A 1UHPA 5HJ1A
chains in the Genus database with same CATH topology
2EGOA 3LNYA 4Q2OA 2OPGA 5I7ZA 3HPMA 2JSNA 2LC7A 3BPUA 5E6PB 3CBZA 2K1ZA 3FY5A 4NMVA 3RLEA 2FCFA 3OU0A 2DLSA 5HEBA 1V5LA 3NFLA 3RL7A 1MFLA 2Q9VA 3I1EA 4JOEA 1Z86A 2K20A 1UM7A 4K76A 4E3BA 1NTEA 1RGRA 1UEPA 2BYGA 3R0HA 4PQWA 2FE5A 2DB5A 2AWWA 3GCOA 2EJYA 1KEFA 1R6JA 4Q3HA 1V62A 4REYA 1N6DA 1G9OA 3GSLA 2EEJA 2FNEA 1TE0A 5E11A 2OMJA 2OZFA 5G1EA 1N6FA 2G2LA 2QKVA 5IL9A 3QO6A 5HF1A 1MC7A 2Z17A 1WF7A 4JJ3A 1X5QA 2JILA 2I0IA 2KOMA 4G69A 2G5MB 1WI4A 2QKTA 3RL8A 4K78A 2E7KA 3MH6A 1VB7A 2EXGA 2KAWA 3CBXA 3K1RA 2DLUA 2KJDA 2W4FA 4NMRA 1GM1A 4N6XA 2L97A 5EYZA 2M10A 4EDJA 2M3MA 1RZXA 1Z87A 3QE1A 1QAVA 3NGHA 5E21A 2V1WA 3MH7A 3QDOA 3TSZA 2IWOA 1W9EA 2YT8A 1TP5A 3JXTA 2ZPMA 3I4WA 3QGLA 1X45A 1UJVA 1V1TA 1UJUA 2EGNA 1WIFA 3SHUA 1FC7A 2KBSA 2R4HA 3WKLA 1U38A 3KZDA 4NMQA 1U37A 3QJMA 2JWEA 4OAJA 2OCSA 4OEOA 1N7FA 1UEZA 1UM1A 2CSSA 2UZCA 2L4SA 2QBWA 2DAZA 3ID4A 4XHVA 2JIKA 1WFGA 2PNTA 2OGPA 3O5NA 4FLNA 3QJNA 2VSVA 2KOJA 1WJLA 4K6YA 4NXPA 1UITA 2Z9IA 1BE9A 4JOGA 5HFCA 5HEDA 5HFFA 3PV4A 1QAVB 4E35A 3SOEA 3K82A 3GDSA 5F67A 2CS5A 3PV5A 2QT5A 2X7ZA 2QKUA 3CBYA 4K75A 5B42A 1UEQA 4NNMA 2KRGA 4F8KA 3HVQC 4Q2PA 2V90A 2YTWA 2H3MA 2IWPA 2VPHA 1LCYA 5HF4A 1TP3A 2EHRA 1UEWA 1UJDA 2W7RA 3GCNA 3CS0A 1X5NA 4FGMA 1VCWA 5FB8C 4HOPA 5ILBA 2EEHA 2EAQA 3NCVA 5HFDA 3WKMA 4NXQA 3SUZA 1X9ZA 2OQSA 4Q6HA 5E22A 4Z8JA 2VRFA 1KWAA 2DC2A 1UF1A 3DIWA 2LC6A 2D92A 3SHWA 1Q7XA 3HPKA 4LMMA 1IU0A 4Q2QA 4JOPA 3DORA 1L6OA 2LA8A 3KHFA 4OEPA 2GZVA 3DJ1A 1SOZA 1M5ZA 5A2PA 2HE4A 2PDZA 5GLJA 5HFEA 3R69A 4HOPB 2DM8A 1VJ6A 2JOAA 4JJ0A 1FC9A 2JINA 2KV8A 3LNXA 1X8SA 4NMOA 1Q3OA 2D8IA 3TSVA 5HDYA 2OSGA 1X6DA 3ID3A 2EDPA 5H3JA 4L8NA 2EGKA 1V5QA 1OBZA 5B6LA 3PDVA 4JORA 1MFGA 4KFVA 1U39A 3EGHC 2I4SA 4Q2NA 2KL1A 4GVCA 2ZPLA 2M0TA 1Y7NA 2P3WA 1W9OA 5G1DA 1VAEA 4NXRA 1BFEA 2H2BA 1N7EA 2JREA 3GJ9A 4UU5A 3QIKA 2I1NA 4NMSA 1P1DA 2IWNA 2AWXA 2I0LA 1XZ9A 1GQ5A 2HGAA 1RY4A 1T2MA 1NF3C 2H3LA 2KG2A 2KPLA 2M0ZA 4WYTA 4E34A 1Q3PA 2EEGA 2MX6A 2KJPA 2O2TA 1VA8A 2REYA 2EDVA 2KYLA 3SFJA 4GVDA 1U3BA 1P1EA 2F5YA 1WF8A 1Y8TA 3MH4A 2VZ5A 4YDPA 2M0VA 2RRMA 2KA9A 1I92A 3ZRTA 2KPKA 2L4TA 4Q6SA 3B76A 5GNDA 2FN5A 2KQFA 3GDUA 1B8QA 3ID1A 3EGGC 1IU2A 2ENOA 2Q3GA 3GGEA 4MPAA 5F3XA 5HETA 4NNLA 2QG1A 3ID2A 4O06A 2YUBA 4IC6A 3PDZA 3E17A 3KDKA 1ZUBA 1WG6A 2CSJA 1WI2A 2PKUA 3R68A 4JOFA 1WH1A 4GHNA 2WL7A 3CH8A 2MHOA 3PS4A 2VWRA 2LOBA 3O46A 1UFXA 1N7TA 2HE2A 3GDVA 1KY9A 3GABA 4JL7A 1W9QA 1V6BA 2KJKA 3VQFA 2DMZA 1I16A 3K50A 3KDGA 2DJTA 4AMHA 2PA1A 3AXAA 5D13A 1OBXA 2YT7A 3NFKA 1QAUA 2R3YA 2EEIA 5HEYA 1WFVA 2D90A 4P0CA 3TMHA 4JOHA 4NMTA 1YBOA 5FHTA 1OZIA 2KOHA 1X5RA 1N6EA 2PZDA 5EZ0A 5JXBA 4RI0A 5DTHA 3KZEA 3I18A 1IHJA 1PDRA 2LUIA 2F0AA 2I04A 4JOJA 3VQGA 2AWUA 4Z33A 2YUYA 2IWQA 2H2CA 1K32A 4WYUA 2PKTA 2EDZA 2OS6A 2DKRA 4K72A 4R2ZA 4UU6A 1RGWA 1WHAA 2RCZA 3STJA 4JOKA 1QLCA 1WHDA 1OBYA 2AINA 1SOTA 3CC0A 3TSWA 2VSPA 3OTPA 2EV8A 3L4FD 4YYXA 1D5GA 5E1YA 1TQ3A 2M0UA 4P2AB 1N99A 2I6VA 1FCFA 5HFBA 4KFWA 2JXOA 3CYYA 4NMPA 4H11A 1ZOKA 3PV2A 2GEFA 1FC6A 3DJ3A 3DJAA 1GQ4A 1UHPA 5HJ1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EGO A;  3LNY A;  4Q2O A;  2OPG A;  5I7Z A;  3HPM A;  2LC7 A;  3BPU A;  5E6P B;  3CBZ A;  2K1Z A;  3FY5 A;  4NMV A;  3RLE A;  2FCF A;  3OU0 A;  2DLS A;  5HEB A;  1V5L A;  3NFL A;  3RL7 A;  1MFL A;  2Q9V A;  3I1E A;  4JOE A;  1Z86 A;  2K20 A;  1UM7 A;  4K76 A;  4E3B A;  1NTE A;  1RGR A;  1UEP A;  2BYG A;  3R0H A;  4PQW A;  2FE5 A;  2DB5 A;  2AWW A;  3GCO A;  2EJY A;  1KEF A;  1R6J A;  4Q3H A;  1V62 A;  4REY A;  1N6D A;  1G9O A;  3GSL A;  2EEJ A;  2FNE A;  1TE0 A;  5E11 A;  2OMJ A;  2OZF A;  5G1E A;  1N6F A;  2G2L A;  2QKV A;  3QO6 A;  5HF1 A;  1MC7 A;  2Z17 A;  1WF7 A;  1X5Q A;  2JIL A;  2I0I A;  2KOM A;  4G69 A;  2G5M B;  1WI4 A;  2QKT A;  3RL8 A;  4K78 A;  2E7K A;  3MH6 A;  1VB7 A;  2EXG A;  2KAW A;  3CBX A;  3K1R A;  2DLU A;  2KJD A;  2W4F A;  4NMR A;  1GM1 A;  4N6X A;  2L97 A;  5EYZ A;  2M10 A;  4EDJ A;  2M3M A;  1RZX A;  1Z87 A;  3QE1 A;  1QAV A;  3NGH A;  5E21 A;  2V1W A;  3MH7 A;  3QDO A;  3TSZ A;  2IWO A;  1W9E A;  2YT8 A;  1TP5 A;  3JXT A;  2ZPM A;  3I4W A;  3QGL A;  1X45 A;  1UJV A;  1V1T A;  1UJU A;  2EGN A;  1WIF A;  3SHU A;  1FC7 A;  2KBS A;  2R4H A;  3WKL A;  1U38 A;  3KZD A;  4NMQ A;  1U37 A;  3QJM A;  2JWE A;  4OAJ A;  2OCS A;  4OEO A;  1N7F A;  1UEZ A;  1UM1 A;  2CSS A;  2UZC A;  2L4S A;  2QBW A;  2DAZ A;  3ID4 A;  4XHV A;  2JIK A;  1WFG A;  2PNT A;  2OGP A;  3O5N A;  3QJN A;  2VSV A;  2KOJ A;  1WJL A;  4K6Y A;  4NXP A;  1UIT A;  2Z9I A;  1BE9 A;  4JOG A;  5HFC A;  5HED A;  5HFF A;  3PV4 A;  1QAV B;  4E35 A;  3SOE A;  3K82 A;  3GDS A;  5F67 A;  2CS5 A;  3PV5 A;  2QT5 A;  2X7Z A;  2QKU A;  3CBY A;  4K75 A;  1UEQ A;  4NNM A;  2KRG A;  4F8K A;  3HVQ C;  4Q2P A;  2V90 A;  2YTW A;  2H3M A;  2IWP A;  2VPH A;  1LCY A;  5HF4 A;  1TP3 A;  2EHR A;  1UEW A;  1UJD A;  2W7R A;  3GCN A;  3CS0 A;  1X5N A;  4FGM A;  1VCW A;  5FB8 C;  4HOP A;  2EEH A;  2EAQ A;  5HFD A;  3WKM A;  4NXQ A;  3SUZ A;  2OQS A;  4Q6H A;  5E22 A;  4Z8J A;  2VRF A;  1KWA A;  2DC2 A;  1UF1 A;  3DIW A;  2LC6 A;  2D92 A;  3SHW A;  1Q7X A;  3HPK A;  4LMM A;  1IU0 A;  4Q2Q A;  4JOP A;  3DOR A;  1L6O A;  2LA8 A;  3KHF A;  4OEP A;  2GZV A;  3DJ1 A;  1SOZ A;  1M5Z A;  5A2P A;  2HE4 A;  2PDZ A;  5GLJ A;  5HFE A;  3R69 A;  4HOP B;  2DM8 A;  1VJ6 A;  2JOA A;  1FC9 A;  2JIN A;  2KV8 A;  3LNX A;  1X8S A;  4NMO A;  1Q3O A;  2D8I A;  3TSV A;  5HDY A;  2OSG A;  1X6D A;  3ID3 A;  2EDP A;  5H3J A;  4L8N A;  2EGK A;  1V5Q A;  1OBZ A;  5B6L A;  3PDV A;  4JOR A;  1MFG A;  4KFV A;  1U39 A;  3EGH C;  2I4S A;  4Q2N A;  2KL1 A;  4GVC A;  2ZPL A;  2M0T A;  1Y7N A;  2P3W A;  1W9O A;  5G1D A;  1VAE A;  4NXR A;  1BFE A;  2H2B A;  1N7E A;  2JRE A;  3GJ9 A;  4UU5 A;  3QIK A;  2I1N A;  4NMS A;  1P1D A;  2IWN A;  2AWX A;  2I0L A;  1XZ9 A;  1GQ5 A;  2HGA A;  1RY4 A;  1T2M A;  1NF3 C;  2H3L A;  2KG2 A;  2KPL A;  2M0Z A;  4WYT A;  4E34 A;  1Q3P A;  2EEG A;  2MX6 A;  2KJP A;  2O2T A;  1VA8 A;  2REY A;  2EDV A;  2KYL A;  3SFJ A;  4GVD A;  1U3B A;  1P1E A;  2F5Y A;  1WF8 A;  1Y8T A;  3MH4 A;  2VZ5 A;  4YDP A;  2M0V A;  2RRM A;  2KA9 A;  1I92 A;  3ZRT A;  2KPK A;  2L4T A;  4Q6S A;  3B76 A;  5GND A;  2FN5 A;  2KQF A;  3GDU A;  1B8Q A;  3ID1 A;  3EGG C;  1IU2 A;  2ENO A;  2Q3G A;  3GGE A;  4MPA A;  5F3X A;  5HET A;  4NNL A;  2QG1 A;  3ID2 A;  4O06 A;  2YUB A;  4IC6 A;  3PDZ A;  3E17 A;  1ZUB A;  1WG6 A;  2CSJ A;  1WI2 A;  2PKU A;  3R68 A;  4JOF A;  1WH1 A;  4GHN A;  2WL7 A;  3CH8 A;  2MHO A;  3PS4 A;  2VWR A;  2LOB A;  3O46 A;  1UFX A;  1N7T A;  2HE2 A;  3GDV A;  1KY9 A;  4JL7 A;  1W9Q A;  1V6B A;  2KJK A;  3VQF A;  2DMZ A;  1I16 A;  3K50 A;  2DJT A;  4AMH A;  2PA1 A;  3AXA A;  5D13 A;  1OBX A;  2YT7 A;  3NFK A;  1QAU A;  2R3Y A;  2EEI A;  5HEY A;  1WFV A;  2D90 A;  4P0C A;  3TMH A;  4JOH A;  4NMT A;  1YBO A;  5FHT A;  1OZI A;  2KOH A;  1X5R A;  1N6E A;  2PZD A;  5EZ0 A;  5JXB A;  4RI0 A;  5DTH A;  3KZE A;  3I18 A;  1IHJ A;  1PDR A;  2LUI A;  2F0A A;  2I04 A;  4JOJ A;  3VQG A;  2AWU A;  4Z33 A;  2YUY A;  2IWQ A;  2H2C A;  1K32 A;  4WYU A;  2PKT A;  2EDZ A;  2OS6 A;  2DKR A;  4K72 A;  4R2Z A;  4UU6 A;  1RGW A;  1WHA A;  2RCZ A;  3STJ A;  4JOK A;  1QLC A;  1WHD A;  1OBY A;  2AIN A;  1SOT A;  3CC0 A;  3TSW A;  2VSP A;  3OTP A;  2EV8 A;  3L4F D;  4YYX A;  1D5G A;  5E1Y A;  1TQ3 A;  2M0U A;  4P2A B;  1N99 A;  2I6V A;  1FCF A;  5HFB A;  4KFW A;  2JXO A;  3CYY A;  4NMP A;  4H11 A;  1ZOK A;  3PV2 A;  1FC6 A;  3DJ3 A;  3DJA A;  1GQ4 A;  1UHP A;  5HJ1 A; 
#chains in the Genus database with same CATH topology
 2EGO A;  3LNY A;  4Q2O A;  2OPG A;  5I7Z A;  3HPM A;  2JSN A;  2LC7 A;  3BPU A;  5E6P B;  3CBZ A;  2K1Z A;  3FY5 A;  4NMV A;  3RLE A;  2FCF A;  3OU0 A;  2DLS A;  5HEB A;  1V5L A;  3NFL A;  3RL7 A;  1MFL A;  2Q9V A;  3I1E A;  4JOE A;  1Z86 A;  2K20 A;  1UM7 A;  4K76 A;  4E3B A;  1NTE A;  1RGR A;  1UEP A;  2BYG A;  3R0H A;  4PQW A;  2FE5 A;  2DB5 A;  2AWW A;  3GCO A;  2EJY A;  1KEF A;  1R6J A;  4Q3H A;  1V62 A;  4REY A;  1N6D A;  1G9O A;  3GSL A;  2EEJ A;  2FNE A;  1TE0 A;  5E11 A;  2OMJ A;  2OZF A;  5G1E A;  1N6F A;  2G2L A;  2QKV A;  5IL9 A;  3QO6 A;  5HF1 A;  1MC7 A;  2Z17 A;  1WF7 A;  4JJ3 A;  1X5Q A;  2JIL A;  2I0I A;  2KOM A;  4G69 A;  2G5M B;  1WI4 A;  2QKT A;  3RL8 A;  4K78 A;  2E7K A;  3MH6 A;  1VB7 A;  2EXG A;  2KAW A;  3CBX A;  3K1R A;  2DLU A;  2KJD A;  2W4F A;  4NMR A;  1GM1 A;  4N6X A;  2L97 A;  5EYZ A;  2M10 A;  4EDJ A;  2M3M A;  1RZX A;  1Z87 A;  3QE1 A;  1QAV A;  3NGH A;  5E21 A;  2V1W A;  3MH7 A;  3QDO A;  3TSZ A;  2IWO A;  1W9E A;  2YT8 A;  1TP5 A;  3JXT A;  2ZPM A;  3I4W A;  3QGL A;  1X45 A;  1UJV A;  1V1T A;  1UJU A;  2EGN A;  1WIF A;  3SHU A;  1FC7 A;  2KBS A;  2R4H A;  3WKL A;  1U38 A;  3KZD A;  4NMQ A;  1U37 A;  3QJM A;  2JWE A;  4OAJ A;  2OCS A;  4OEO A;  1N7F A;  1UEZ A;  1UM1 A;  2CSS A;  2UZC A;  2L4S A;  2QBW A;  2DAZ A;  3ID4 A;  4XHV A;  2JIK A;  1WFG A;  2PNT A;  2OGP A;  3O5N A;  4FLN A;  3QJN A;  2VSV A;  2KOJ A;  1WJL A;  4K6Y A;  4NXP A;  1UIT A;  2Z9I A;  1BE9 A;  4JOG A;  5HFC A;  5HED A;  5HFF A;  3PV4 A;  1QAV B;  4E35 A;  3SOE A;  3K82 A;  3GDS A;  5F67 A;  2CS5 A;  3PV5 A;  2QT5 A;  2X7Z A;  2QKU A;  3CBY A;  4K75 A;  5B42 A;  1UEQ A;  4NNM A;  2KRG A;  4F8K A;  3HVQ C;  4Q2P A;  2V90 A;  2YTW A;  2H3M A;  2IWP A;  2VPH A;  1LCY A;  5HF4 A;  1TP3 A;  2EHR A;  1UEW A;  1UJD A;  2W7R A;  3GCN A;  3CS0 A;  1X5N A;  4FGM A;  1VCW A;  5FB8 C;  4HOP A;  5ILB A;  2EEH A;  2EAQ A;  3NCV A;  5HFD A;  3WKM A;  4NXQ A;  3SUZ A;  1X9Z A;  2OQS A;  4Q6H A;  5E22 A;  4Z8J A;  2VRF A;  1KWA A;  2DC2 A;  1UF1 A;  3DIW A;  2LC6 A;  2D92 A;  3SHW A;  1Q7X A;  3HPK A;  4LMM A;  1IU0 A;  4Q2Q A;  4JOP A;  3DOR A;  1L6O A;  2LA8 A;  3KHF A;  4OEP A;  2GZV A;  3DJ1 A;  1SOZ A;  1M5Z A;  5A2P A;  2HE4 A;  2PDZ A;  5GLJ A;  5HFE A;  3R69 A;  4HOP B;  2DM8 A;  1VJ6 A;  2JOA A;  4JJ0 A;  1FC9 A;  2JIN A;  2KV8 A;  3LNX A;  1X8S A;  4NMO A;  1Q3O A;  2D8I A;  3TSV A;  5HDY A;  2OSG A;  1X6D A;  3ID3 A;  2EDP A;  5H3J A;  4L8N A;  2EGK A;  1V5Q A;  1OBZ A;  5B6L A;  3PDV A;  4JOR A;  1MFG A;  4KFV A;  1U39 A;  3EGH C;  2I4S A;  4Q2N A;  2KL1 A;  4GVC A;  2ZPL A;  2M0T A;  1Y7N A;  2P3W A;  1W9O A;  5G1D A;  1VAE A;  4NXR A;  1BFE A;  2H2B A;  1N7E A;  2JRE A;  3GJ9 A;  4UU5 A;  3QIK A;  2I1N A;  4NMS A;  1P1D A;  2IWN A;  2AWX A;  2I0L A;  1XZ9 A;  1GQ5 A;  2HGA A;  1RY4 A;  1T2M A;  1NF3 C;  2H3L A;  2KG2 A;  2KPL A;  2M0Z A;  4WYT A;  4E34 A;  1Q3P A;  2EEG A;  2MX6 A;  2KJP A;  2O2T A;  1VA8 A;  2REY A;  2EDV A;  2KYL A;  3SFJ A;  4GVD A;  1U3B A;  1P1E A;  2F5Y A;  1WF8 A;  1Y8T A;  3MH4 A;  2VZ5 A;  4YDP A;  2M0V A;  2RRM A;  2KA9 A;  1I92 A;  3ZRT A;  2KPK A;  2L4T A;  4Q6S A;  3B76 A;  5GND A;  2FN5 A;  2KQF A;  3GDU A;  1B8Q A;  3ID1 A;  3EGG C;  1IU2 A;  2ENO A;  2Q3G A;  3GGE A;  4MPA A;  5F3X A;  5HET A;  4NNL A;  2QG1 A;  3ID2 A;  4O06 A;  2YUB A;  4IC6 A;  3PDZ A;  3E17 A;  3KDK A;  1ZUB A;  1WG6 A;  2CSJ A;  1WI2 A;  2PKU A;  3R68 A;  4JOF A;  1WH1 A;  4GHN A;  2WL7 A;  3CH8 A;  2MHO A;  3PS4 A;  2VWR A;  2LOB A;  3O46 A;  1UFX A;  1N7T A;  2HE2 A;  3GDV A;  1KY9 A;  3GAB A;  4JL7 A;  1W9Q A;  1V6B A;  2KJK A;  3VQF A;  2DMZ A;  1I16 A;  3K50 A;  3KDG A;  2DJT A;  4AMH A;  2PA1 A;  3AXA A;  5D13 A;  1OBX A;  2YT7 A;  3NFK A;  1QAU A;  2R3Y A;  2EEI A;  5HEY A;  1WFV A;  2D90 A;  4P0C A;  3TMH A;  4JOH A;  4NMT A;  1YBO A;  5FHT A;  1OZI A;  2KOH A;  1X5R A;  1N6E A;  2PZD A;  5EZ0 A;  5JXB A;  4RI0 A;  5DTH A;  3KZE A;  3I18 A;  1IHJ A;  1PDR A;  2LUI A;  2F0A A;  2I04 A;  4JOJ A;  3VQG A;  2AWU A;  4Z33 A;  2YUY A;  2IWQ A;  2H2C A;  1K32 A;  4WYU A;  2PKT A;  2EDZ A;  2OS6 A;  2DKR A;  4K72 A;  4R2Z A;  4UU6 A;  1RGW A;  1WHA A;  2RCZ A;  3STJ A;  4JOK A;  1QLC A;  1WHD A;  1OBY A;  2AIN A;  1SOT A;  3CC0 A;  3TSW A;  2VSP A;  3OTP A;  2EV8 A;  3L4F D;  4YYX A;  1D5G A;  5E1Y A;  1TQ3 A;  2M0U A;  4P2A B;  1N99 A;  2I6V A;  1FCF A;  5HFB A;  4KFW A;  2JXO A;  3CYY A;  4NMP A;  4H11 A;  1ZOK A;  3PV2 A;  2GEF A;  1FC6 A;  3DJ3 A;  3DJA A;  1GQ4 A;  1UHP A;  5HJ1 A; 
#chains in the Genus database with same CATH homology
 2EGO A;  3LNY A;  4Q2O A;  2OPG A;  5I7Z A;  3HPM A;  2JSN A;  2LC7 A;  3BPU A;  5E6P B;  3CBZ A;  2K1Z A;  3FY5 A;  4NMV A;  3RLE A;  2FCF A;  3OU0 A;  2DLS A;  5HEB A;  1V5L A;  3NFL A;  3RL7 A;  1MFL A;  2Q9V A;  3I1E A;  4JOE A;  1Z86 A;  2K20 A;  1UM7 A;  4K76 A;  4E3B A;  1NTE A;  1RGR A;  1UEP A;  2BYG A;  3R0H A;  4PQW A;  2FE5 A;  2DB5 A;  2AWW A;  3GCO A;  2EJY A;  1KEF A;  1R6J A;  4Q3H A;  1V62 A;  4REY A;  1N6D A;  1G9O A;  3GSL A;  2EEJ A;  2FNE A;  1TE0 A;  5E11 A;  2OMJ A;  2OZF A;  5G1E A;  1N6F A;  2G2L A;  2QKV A;  5IL9 A;  3QO6 A;  5HF1 A;  1MC7 A;  2Z17 A;  1WF7 A;  4JJ3 A;  1X5Q A;  2JIL A;  2I0I A;  2KOM A;  4G69 A;  2G5M B;  1WI4 A;  2QKT A;  3RL8 A;  4K78 A;  2E7K A;  3MH6 A;  1VB7 A;  2EXG A;  2KAW A;  3CBX A;  3K1R A;  2DLU A;  2KJD A;  2W4F A;  4NMR A;  1GM1 A;  4N6X A;  2L97 A;  5EYZ A;  2M10 A;  4EDJ A;  2M3M A;  1RZX A;  1Z87 A;  3QE1 A;  1QAV A;  3NGH A;  5E21 A;  2V1W A;  3MH7 A;  3QDO A;  3TSZ A;  2IWO A;  1W9E A;  2YT8 A;  1TP5 A;  3JXT A;  2ZPM A;  3I4W A;  3QGL A;  1X45 A;  1UJV A;  1V1T A;  1UJU A;  2EGN A;  1WIF A;  3SHU A;  1FC7 A;  2KBS A;  2R4H A;  3WKL A;  1U38 A;  3KZD A;  4NMQ A;  1U37 A;  3QJM A;  2JWE A;  4OAJ A;  2OCS A;  4OEO A;  1N7F A;  1UEZ A;  1UM1 A;  2CSS A;  2UZC A;  2L4S A;  2QBW A;  2DAZ A;  3ID4 A;  4XHV A;  2JIK A;  1WFG A;  2PNT A;  2OGP A;  3O5N A;  4FLN A;  3QJN A;  2VSV A;  2KOJ A;  1WJL A;  4K6Y A;  4NXP A;  1UIT A;  2Z9I A;  1BE9 A;  4JOG A;  5HFC A;  5HED A;  5HFF A;  3PV4 A;  1QAV B;  4E35 A;  3SOE A;  3K82 A;  3GDS A;  5F67 A;  2CS5 A;  3PV5 A;  2QT5 A;  2X7Z A;  2QKU A;  3CBY A;  4K75 A;  5B42 A;  1UEQ A;  4NNM A;  2KRG A;  4F8K A;  3HVQ C;  4Q2P A;  2V90 A;  2YTW A;  2H3M A;  2IWP A;  2VPH A;  1LCY A;  5HF4 A;  1TP3 A;  2EHR A;  1UEW A;  1UJD A;  2W7R A;  3GCN A;  3CS0 A;  1X5N A;  4FGM A;  1VCW A;  5FB8 C;  4HOP A;  5ILB A;  2EEH A;  2EAQ A;  3NCV A;  5HFD A;  3WKM A;  4NXQ A;  3SUZ A;  1X9Z A;  2OQS A;  4Q6H A;  5E22 A;  4Z8J A;  2VRF A;  1KWA A;  2DC2 A;  1UF1 A;  3DIW A;  2LC6 A;  2D92 A;  3SHW A;  1Q7X A;  3HPK A;  4LMM A;  1IU0 A;  4Q2Q A;  4JOP A;  3DOR A;  1L6O A;  2LA8 A;  3KHF A;  4OEP A;  2GZV A;  3DJ1 A;  1SOZ A;  1M5Z A;  5A2P A;  2HE4 A;  2PDZ A;  5GLJ A;  5HFE A;  3R69 A;  4HOP B;  2DM8 A;  1VJ6 A;  2JOA A;  4JJ0 A;  1FC9 A;  2JIN A;  2KV8 A;  3LNX A;  1X8S A;  4NMO A;  1Q3O A;  2D8I A;  3TSV A;  5HDY A;  2OSG A;  1X6D A;  3ID3 A;  2EDP A;  5H3J A;  4L8N A;  2EGK A;  1V5Q A;  1OBZ A;  5B6L A;  3PDV A;  4JOR A;  1MFG A;  4KFV A;  1U39 A;  3EGH C;  2I4S A;  4Q2N A;  2KL1 A;  4GVC A;  2ZPL A;  2M0T A;  1Y7N A;  2P3W A;  1W9O A;  5G1D A;  1VAE A;  4NXR A;  1BFE A;  2H2B A;  1N7E A;  2JRE A;  3GJ9 A;  4UU5 A;  3QIK A;  2I1N A;  4NMS A;  1P1D A;  2IWN A;  2AWX A;  2I0L A;  1XZ9 A;  1GQ5 A;  2HGA A;  1RY4 A;  1T2M A;  1NF3 C;  2H3L A;  2KG2 A;  2KPL A;  2M0Z A;  4WYT A;  4E34 A;  1Q3P A;  2EEG A;  2MX6 A;  2KJP A;  2O2T A;  1VA8 A;  2REY A;  2EDV A;  2KYL A;  3SFJ A;  4GVD A;  1U3B A;  1P1E A;  2F5Y A;  1WF8 A;  1Y8T A;  3MH4 A;  2VZ5 A;  4YDP A;  2M0V A;  2RRM A;  2KA9 A;  1I92 A;  3ZRT A;  2KPK A;  2L4T A;  4Q6S A;  3B76 A;  5GND A;  2FN5 A;  2KQF A;  3GDU A;  1B8Q A;  3ID1 A;  3EGG C;  1IU2 A;  2ENO A;  2Q3G A;  3GGE A;  4MPA A;  5F3X A;  5HET A;  4NNL A;  2QG1 A;  3ID2 A;  4O06 A;  2YUB A;  4IC6 A;  3PDZ A;  3E17 A;  3KDK A;  1ZUB A;  1WG6 A;  2CSJ A;  1WI2 A;  2PKU A;  3R68 A;  4JOF A;  1WH1 A;  4GHN A;  2WL7 A;  3CH8 A;  2MHO A;  3PS4 A;  2VWR A;  2LOB A;  3O46 A;  1UFX A;  1N7T A;  2HE2 A;  3GDV A;  1KY9 A;  3GAB A;  4JL7 A;  1W9Q A;  1V6B A;  2KJK A;  3VQF A;  2DMZ A;  1I16 A;  3K50 A;  3KDG A;  2DJT A;  4AMH A;  2PA1 A;  3AXA A;  5D13 A;  1OBX A;  2YT7 A;  3NFK A;  1QAU A;  2R3Y A;  2EEI A;  5HEY A;  1WFV A;  2D90 A;  4P0C A;  3TMH A;  4JOH A;  4NMT A;  1YBO A;  5FHT A;  1OZI A;  2KOH A;  1X5R A;  1N6E A;  2PZD A;  5EZ0 A;  5JXB A;  4RI0 A;  5DTH A;  3KZE A;  3I18 A;  1IHJ A;  1PDR A;  2LUI A;  2F0A A;  2I04 A;  4JOJ A;  3VQG A;  2AWU A;  4Z33 A;  2YUY A;  2IWQ A;  2H2C A;  1K32 A;  4WYU A;  2PKT A;  2EDZ A;  2OS6 A;  2DKR A;  4K72 A;  4R2Z A;  4UU6 A;  1RGW A;  1WHA A;  2RCZ A;  3STJ A;  4JOK A;  1QLC A;  1WHD A;  1OBY A;  2AIN A;  1SOT A;  3CC0 A;  3TSW A;  2VSP A;  3OTP A;  2EV8 A;  3L4F D;  4YYX A;  1D5G A;  5E1Y A;  1TQ3 A;  2M0U A;  4P2A B;  1N99 A;  2I6V A;  1FCF A;  5HFB A;  4KFW A;  2JXO A;  3CYY A;  4NMP A;  4H11 A;  1ZOK A;  3PV2 A;  2GEF A;  1FC6 A;  3DJ3 A;  3DJA A;  1GQ4 A;  1UHP A;  5HJ1 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...